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Gene: TAAR5 (trace amine associated receptor 5) Homo sapiens

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Symbol:

TAAR5

Name:

trace amine associated receptor 5

RGD ID:

1603706

HGNC Page

HGNC:30236

Description:

Enables trimethylamine receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Is active in plasma membrane.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

hTaar5; MGC138414; MGC138416; PNR; putative neurotransmitter receptor; RP11-295F4.5; taR-5; trace amine receptor 5; trace amine-associated receptor 5

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Allele / Splice:

See ClinVar data

Latest Assembly:

GRCh38 - Human Genome Assembly GRCh38

Position:

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	132,588,592 - 132,616,747 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	132,588,592 - 132,589,741 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	132,909,731 - 132,937,886 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	132,951,505 - 132,952,518 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	133,656,568 - 133,657,714 (-)	NCBI		Celera
Cytogenetic Map	6	q23.2	NCBI
HuRef	6	130,484,645 - 130,485,791 (-)	NCBI		HuRef
CHM1_1	6	133,173,402 - 133,174,548 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	133,783,556 - 133,811,705 (-)	NCBI		T2T-CHM13v2.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-catechin (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

Azoxymethane (ISO)

benzo[a]pyrene (EXP)

CGP 52608 (EXP)

dextran sulfate (ISO)

indole-3-methanol (ISO)

N-nitrosodiethylamine (ISO)

resveratrol (EXP)

titanium dioxide (ISO)

trimethylamine (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IDA,IEA,ISS)

cognition (IEA,ISS)

G protein-coupled receptor signaling pathway (IBA,IEA,TAS)

sensory perception of chemical stimulus (IEA)

sensory perception of smell (ISS)

signal transduction (TAS)

Cellular Component

membrane (IEA)

plasma membrane (IBA,IDA,IEA,TAS)

Molecular Function

G protein-coupled receptor activity (IEA,TAS)

trace-amine receptor activity (IBA,IEA)

trimethylamine receptor activity (IDA,IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:9464258	PMID:12477932	PMID:14574404	PMID:15489334	PMID:15718104	PMID:16878137	PMID:18240029	PMID:20559446	PMID:21873635	PMID:23393561	PMID:25706283	PMID:33035477
PMID:34445502	PMID:37225986

Genomics

Comparative Map Data

TAAR5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	132,588,592 - 132,616,747 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	132,588,592 - 132,589,741 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	132,909,731 - 132,937,886 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	132,951,505 - 132,952,518 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	133,656,568 - 133,657,714 (-)	NCBI		Celera
Cytogenetic Map	6	q23.2	NCBI
HuRef	6	130,484,645 - 130,485,791 (-)	NCBI		HuRef
CHM1_1	6	133,173,402 - 133,174,548 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	133,783,556 - 133,811,705 (-)	NCBI		T2T-CHM13v2.0

Taar5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	23,846,604 - 23,847,617 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	23,846,604 - 23,847,617 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	23,970,706 - 23,971,719 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	23,970,706 - 23,971,719 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	23,690,512 - 23,691,525 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	23,660,122 - 23,661,135 (+)	NCBI		MGSCv36	mm8
Celera	10	24,904,076 - 24,905,089 (+)	NCBI		Celera
Cytogenetic Map	10	A4	NCBI
cM Map	10	11.4	NCBI

Taar5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	23,289,163 - 23,290,176 (-)	NCBI		GRCr8
mRatBN7.2	1	21,469,923 - 21,470,936 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	21,469,923 - 21,470,936 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	21,246,888 - 21,247,901 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	27,246,933 - 27,247,946 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	21,446,572 - 21,447,585 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	22,547,662 - 22,548,675 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	22,547,662 - 22,548,675 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	24,022,589 - 24,023,602 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	21,996,992 - 21,998,005 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	21,999,937 - 22,000,950 (-)	NCBI
Celera	1	20,213,693 - 20,214,706 (-)	NCBI		Celera
Cytogenetic Map	1	p12	NCBI

Taar5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955436	13,152,345 - 13,153,358 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955436	13,152,345 - 13,153,358 (-)	NCBI	ChiLan1.0	ChiLan1.0

LOC100976647
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	152,570,996 - 152,572,333 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	150,478,084 - 150,506,651 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	130,364,744 - 130,366,076 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	134,472,911 - 134,474,045 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	134,472,986 - 134,473,999 (-)	Ensembl	panpan1.1		panPan2

TAAR5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	1	26,626,764 - 26,627,777 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	1	25,550,851 - 25,551,864 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	1	25,550,851 - 25,551,864 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	1	25,596,935 - 25,597,948 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	1	25,495,726 - 25,496,739 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	1	25,758,931 - 25,759,944 (-)	NCBI		UU_Cfam_GSD_1.0

Taar5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	120,842,255 - 120,843,395 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936560	621,557 - 622,573 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936560	621,477 - 622,605 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TAAR5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	1	31,104,142 - 31,105,153 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	34,624,798 - 34,625,811 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TAAR5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	40,954,395 - 40,957,978 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	40,956,572 - 40,957,585 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	13,145,071 - 13,146,203 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Taar5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624952	748,649 - 749,660 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624952	747,682 - 750,305 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TAAR5
35 total Variants

Clinical Variants

Name	Type	Condition(s)	Position(s)	Clinical significance
GRCh38/hg38 6q23.2(chr6:132455272-133141153)x3	copy number gain	See cases [RCV000053388]	Chr6:132455272..133141153 [GRCh38] Chr6:132776411..133462292 [GRCh37] Chr6:132818104..133503985 [NCBI36] Chr6:6q23.2	uncertain significance
NM_003967.2(TAAR5):c.850C>A (p.Pro284Thr)	single nucleotide variant	Malignant melanoma [RCV000061317]	Chr6:132588837 [GRCh38] Chr6:132909976 [GRCh37] Chr6:132951669 [NCBI36] Chr6:6q23.2	not provided
GRCh38/hg38 6q13-24.1(chr6:74382807-142040500)x3	copy number gain	See cases [RCV000139729]	Chr6:74382807..142040500 [GRCh38] Chr6:75092523..142361637 [GRCh37] Chr6:75149243..142403330 [NCBI36] Chr6:6q13-24.1	pathogenic
GRCh37/hg19 6q23.2(chr6:132859724-132910636)x1	copy number loss	See cases [RCV000446076]	Chr6:132859724..132910636 [GRCh37] Chr6:6q23.2	uncertain significance
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)x3	copy number gain	See cases [RCV000512067]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:156975-170919482)	copy number gain	See cases [RCV000510595]	Chr6:156975..170919482 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6q23.2-23.3(chr6:131388023-137469640)x1	copy number loss	not provided [RCV000682724]	Chr6:131388023..137469640 [GRCh37] Chr6:6q23.2-23.3	pathogenic
GRCh37/hg19 6q23.2-23.3(chr6:132002460-137160850)x1	copy number loss	not provided [RCV000682725]	Chr6:132002460..137160850 [GRCh37] Chr6:6q23.2-23.3	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:60107-171054786)x3	copy number gain	not provided [RCV000745400]	Chr6:60107..171054786 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:108666-170980171)x3	copy number gain	not provided [RCV000745403]	Chr6:108666..170980171 [GRCh37] Chr6:6p25.3-q27	pathogenic
GRCh37/hg19 6p25.3-q27(chr6:165632-170919470)x3	copy number gain	not provided [RCV000745404]	Chr6:165632..170919470 [GRCh37] Chr6:6p25.3-q27	pathogenic
NM_003967.3(TAAR5):c.420G>C (p.Leu140=)	single nucleotide variant	not provided [RCV000882677]	Chr6:132589267 [GRCh38] Chr6:132910406 [GRCh37] Chr6:6q23.2	benign
NM_003967.3(TAAR5):c.815C>T (p.Thr272Met)	single nucleotide variant	not provided [RCV000968101]	Chr6:132588872 [GRCh38] Chr6:132910011 [GRCh37] Chr6:6q23.2	benign
NM_003967.3(TAAR5):c.200C>T (p.Thr67Met)	single nucleotide variant	not provided [RCV000924818]	Chr6:132589487 [GRCh38] Chr6:132910626 [GRCh37] Chr6:6q23.2	likely benign
NM_003967.3(TAAR5):c.988C>T (p.Arg330Cys)	single nucleotide variant	not provided [RCV000965021]	Chr6:132588699 [GRCh38] Chr6:132909838 [GRCh37] Chr6:6q23.2	benign
NM_003967.3(TAAR5):c.80C>T (p.Thr27Ile)	single nucleotide variant	not specified [RCV004332715]	Chr6:132589607 [GRCh38] Chr6:132910746 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.357C>T (p.Leu119=)	single nucleotide variant	not provided [RCV000924817]	Chr6:132589330 [GRCh38] Chr6:132910469 [GRCh37] Chr6:6q23.2	likely benign
NM_003967.3(TAAR5):c.681C>T (p.Thr227=)	single nucleotide variant	not provided [RCV000956413]	Chr6:132589006 [GRCh38] Chr6:132910145 [GRCh37] Chr6:6q23.2	benign
Single allele	deletion	Interstitial 6q microdeletion syndrome [RCV002280353]	Chr6:115941808..133892653 [GRCh38] Chr6:6q22.1-23.2	pathogenic
GRCh37/hg19 6q23.1-23.3(chr6:130769034-136009217)x1	copy number loss	not provided [RCV001829086]	Chr6:130769034..136009217 [GRCh37] Chr6:6q23.1-23.3	pathogenic
GRCh37/hg19 6q23.2(chr6:132875123-133509642)x3	copy number gain	not provided [RCV001834192]	Chr6:132875123..133509642 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.145G>A (p.Val49Met)	single nucleotide variant	not specified [RCV004213082]	Chr6:132589542 [GRCh38] Chr6:132910681 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.116T>C (p.Leu39Pro)	single nucleotide variant	not specified [RCV004223613]	Chr6:132589571 [GRCh38] Chr6:132910710 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.295T>C (p.Cys99Arg)	single nucleotide variant	not specified [RCV004095045]	Chr6:132589392 [GRCh38] Chr6:132910531 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.710G>T (p.Ser237Ile)	single nucleotide variant	not specified [RCV004169932]	Chr6:132588977 [GRCh38] Chr6:132910116 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.961A>T (p.Ser321Cys)	single nucleotide variant	not specified [RCV004225902]	Chr6:132588726 [GRCh38] Chr6:132909865 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.313T>C (p.Phe105Leu)	single nucleotide variant	not specified [RCV004145985]	Chr6:132589374 [GRCh38] Chr6:132910513 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.119C>A (p.Ala40Asp)	single nucleotide variant	not specified [RCV004096611]	Chr6:132589568 [GRCh38] Chr6:132910707 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.377G>T (p.Cys126Phe)	single nucleotide variant	not specified [RCV004078424]	Chr6:132589310 [GRCh38] Chr6:132910449 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.778A>G (p.Ile260Val)	single nucleotide variant	not specified [RCV004124391]	Chr6:132588909 [GRCh38] Chr6:132910048 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.713A>G (p.Lys238Arg)	single nucleotide variant	not specified [RCV004155141]	Chr6:132588974 [GRCh38] Chr6:132910113 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.359C>T (p.Thr120Ile)	single nucleotide variant	not specified [RCV004158405]	Chr6:132589328 [GRCh38] Chr6:132910467 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.323G>T (p.Arg108Leu)	single nucleotide variant	not specified [RCV004098531]	Chr6:132589364 [GRCh38] Chr6:132910503 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.157G>A (p.Val53Ile)	single nucleotide variant	not specified [RCV004249168]	Chr6:132589530 [GRCh38] Chr6:132910669 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.937C>T (p.Arg313Trp)	single nucleotide variant	not specified [RCV004253462]	Chr6:132588750 [GRCh38] Chr6:132909889 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.343A>G (p.Thr115Ala)	single nucleotide variant	not specified [RCV004252454]	Chr6:132589344 [GRCh38] Chr6:132910483 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.887T>A (p.Phe296Tyr)	single nucleotide variant	not specified [RCV004351108]	Chr6:132588800 [GRCh38] Chr6:132909939 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.617C>T (p.Pro206Leu)	single nucleotide variant	not specified [RCV004365967]	Chr6:132589070 [GRCh38] Chr6:132910209 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.989G>C (p.Arg330Pro)	single nucleotide variant	not specified [RCV004344670]	Chr6:132588698 [GRCh38] Chr6:132909837 [GRCh37] Chr6:6q23.2	likely benign
GRCh37/hg19 6q22.31-23.3(chr6:120218852-137160850)x1	copy number loss	not provided [RCV003482930]	Chr6:120218852..137160850 [GRCh37] Chr6:6q22.31-23.3	pathogenic
NM_003967.3(TAAR5):c.583C>A (p.Leu195Met)	single nucleotide variant	not provided [RCV003428950]	Chr6:132589104 [GRCh38] Chr6:132910243 [GRCh37] Chr6:6q23.2	likely benign
NM_003967.3(TAAR5):c.48C>T (p.Phe16=)	single nucleotide variant	not provided [RCV003432048]	Chr6:132589639 [GRCh38] Chr6:132910778 [GRCh37] Chr6:6q23.2	likely benign
GRCh37/hg19 6q23.2-24.2(chr6:131569837-145572239)x3	copy number gain	not specified [RCV003986663]	Chr6:131569837..145572239 [GRCh37] Chr6:6q23.2-24.2	pathogenic
GRCh37/hg19 6q22.31-25.3(chr6:119840686-156623091)x3	copy number gain	not specified [RCV003986631]	Chr6:119840686..156623091 [GRCh37] Chr6:6q22.31-25.3	pathogenic
NM_003967.3(TAAR5):c.307G>A (p.Gly103Arg)	single nucleotide variant	not specified [RCV004466080]	Chr6:132589380 [GRCh38] Chr6:132910519 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.689C>T (p.Ala230Val)	single nucleotide variant	not specified [RCV004466082]	Chr6:132588998 [GRCh38] Chr6:132910137 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.776G>T (p.Gly259Val)	single nucleotide variant	not specified [RCV004466083]	Chr6:132588911 [GRCh38] Chr6:132910050 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.559C>T (p.Pro187Ser)	single nucleotide variant	not specified [RCV004466081]	Chr6:132589128 [GRCh38] Chr6:132910267 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.496A>G (p.Thr166Ala)	single nucleotide variant	not specified [RCV004671025]	Chr6:132589191 [GRCh38] Chr6:132910330 [GRCh37] Chr6:6q23.2	uncertain significance
NM_003967.3(TAAR5):c.869T>G (p.Phe290Cys)	single nucleotide variant	not specified [RCV004671026]	Chr6:132588818 [GRCh38] Chr6:132909957 [GRCh37] Chr6:6q23.2	uncertain significance
NC_000006.11:g.(?_131894423)_(133849943_?)del	deletion	not provided [RCV004578838]	Chr6:131894423..133849943 [GRCh37] Chr6:6q23.2	pathogenic

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	177
Count of miRNA genes:	170
Interacting mature miRNAs:	177
Transcripts:	ENST00000258034
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region

SHGC-80949

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	132,911,001 - 132,911,280	UniSTS	GRCh37
Build 36	6	132,952,694 - 132,952,973	RGD	NCBI36
Celera	6	133,657,837 - 133,658,116	RGD
Cytogenetic Map	6	q23	UniSTS
HuRef	6	130,485,916 - 130,486,195	UniSTS
TNG Radiation Hybrid Map	6	65612.0	UniSTS

PNR__5739

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	132,909,674 - 132,910,462	UniSTS	GRCh37
Build 36	6	132,951,367 - 132,952,155	RGD	NCBI36
Celera	6	133,656,511 - 133,657,299	RGD
HuRef	6	130,484,588 - 130,485,376	UniSTS

UniSTS:481448

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	132,909,812 - 132,910,825	UniSTS	GRCh37
Celera	6	133,656,649 - 133,657,662	UniSTS
HuRef	6	130,484,726 - 130,485,739	UniSTS

UniSTS:485606

Human Assembly	Chr	Position (strand)	Source	JBrowse
GRCh37	6	132,909,731 - 132,910,877	UniSTS	GRCh37
Celera	6	133,656,568 - 133,657,714	UniSTS
HuRef	6	130,484,645 - 130,485,791	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

adipose tissue	alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system
49	100	98	74	382	54	101	21	175	14	67	347	351	1	365	38	163	73	7

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001389527	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_003967	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF021818	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AL513524	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY702306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC069171	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC095541	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC112209	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC112211	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH471051	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CP068272	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FJ372547	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENST00000258034 ⟹ ENSP00000258034

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38.p14 Ensembl	6	132,588,592 - 132,589,741 (-)	Ensembl

RefSeq Acc Id:

NM_001389527 ⟹ NP_001376456

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	132,588,592 - 132,616,747 (-)	NCBI
T2T-CHM13v2.0	6	133,783,556 - 133,811,705 (-)	NCBI

Sequence:

show sequence

AGTATCTTACCAGATGTACTTTGAAGCATCAGCAACTAAAAATGATAGGAGCTGAAATTTACTG
GAATCATTTTAAGAAGAGAAGAAACAGTGACTCATCCTCCTGGAAAGAAATTTCAAGGGATAAA
GCACCATGGATCTAACTTATATTCCCGAAGACCTATCCAGTTGTCCAAAATTTGTAAATAAATC
CTGTCCTCCCACCAACCGCTCTTTTCATGTCCAGCATGCTCGAGTCATCAGCCATGTGCCTGAA
AACACAAAGGGGGCAGTGAAAAAACACCTATCCAAGAAAAAGGACAGGAAAGCAGCGAAGACAC
TGGTGGAGAAGGTGGCCAGTTCTCAGACAGAGGAAGAGTAGAAATCATAAATGAGAGCTGTCTT
CATCCAAGGTGCTGAAGAGCACCCTGCGGCATTCTGCTACCAGGTGAATGGGTCTTGCCCCAGG
ACAGTACATACTCTGGGCATCCAGTTGGTCATCTACCTGGCCTGTGCAGCAGGCATGCTGATTA
TCGTGCTAGGGAATGTATTTGTGGCATTTGCTGTGTCCTACTTCAAAGCGCTTCACACGCCCAC
CAACTTCCTGCTGCTCTCCCTGGCCCTGGCTGACATGTTTCTGGGTCTGCTGGTGCTGCCCCTC
AGCACCATTCGCTCAGTGGAGAGCTGCTGGTTCTTCGGGGACTTCCTCTGCCGCCTGCACACCT
ACCTGGACACCCTCTTCTGCCTCACCTCCATCTTCCATCTCTGTTTCATTTCCATTGACCGCCA
CTGTGCCATCTGTGACCCCCTGCTCTATCCCTCCAAGTTCACAGTGAGGGTGGCTCTCAGGTAC
ATCCTGGCAGGATGGGGGGTGCCCGCAGCATACACTTCGTTATTCCTCTACACAGATGTGGTAG
AGACAAGGCTCAGCCAGTGGCTGGAAGAGATGCCTTGTGTGGGCAGTTGCCAGCTGCTGCTCAA
TAAATTTTGGGGCTGGTTAAACTTCCCTTTGTTCTTTGTCCCCTGCCTCATTATGATCAGCTTG
TATGTGAAGATCTTTGTGGTTGCTACCAGACAGGCTCAGCAGATTACCACATTGAGCAAAAGCC
TGGCTGGGGCTGCCAAGCATGAGAGAAAAGCTGCCAAGACCCTGGGCATTGCTGTGGGCATATA
CCTCTTGTGCTGGCTGCCCTTCACCATAGACACGATGGTCGACAGCCTCCTTCACTTTATCACA
CCCCCACTGGTCTTTGACATCTTTATCTGGTTTGCTTACTTCAACTCAGCCTGCAACCCCATCA
TCTATGTCTTTTCCTACCAGTGGTTTCGGAAGGCACTGAAACTCACACTGAGCCAGAAGGTCTT
CTCACCGCAGACACGCACTGTTGATTTGTACCAAGAATGATTCCTTCTACTAAATGCAGGCAAG
GAGTAGGACCTCACAGGAAAGATAAGTGGCACTGTGACCGTGGGCTGTGTGGTGTTG

hide sequence

RefSeq Acc Id:

NM_003967 ⟹ NP_003958

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Human Assembly	Chr	Position (strand)	Source
GRCh38	6	132,588,592 - 132,589,741 (-)	NCBI
GRCh37	6	132,909,731 - 132,910,877 (-)	RGD
Build 36	6	132,951,505 - 132,952,518 (-)	NCBI Archive
Celera	6	133,656,568 - 133,657,714 (-)	RGD
HuRef	6	130,484,645 - 130,485,791 (-)	ENTREZGENE
CHM1_1	6	133,173,402 - 133,174,548 (-)	NCBI
T2T-CHM13v2.0	6	133,783,556 - 133,784,705 (-)	NCBI

Sequence:

show sequence

CCCTCCAGTGGAGAAGGTGGCCAGTTCTCAGACAGAGGAAGAGTAGAAATCATAAATGAGAGCT
GTCTTCATCCAAGGTGCTGAAGAGCACCCTGCGGCATTCTGCTACCAGGTGAATGGGTCTTGCC
CCAGGACAGTACATACTCTGGGCATCCAGTTGGTCATCTACCTGGCCTGTGCAGCAGGCATGCT
GATTATCGTGCTAGGGAATGTATTTGTGGCATTTGCTGTGTCCTACTTCAAAGCGCTTCACACG
CCCACCAACTTCCTGCTGCTCTCCCTGGCCCTGGCTGACATGTTTCTGGGTCTGCTGGTGCTGC
CCCTCAGCACCATTCGCTCAGTGGAGAGCTGCTGGTTCTTCGGGGACTTCCTCTGCCGCCTGCA
CACCTACCTGGACACCCTCTTCTGCCTCACCTCCATCTTCCATCTCTGTTTCATTTCCATTGAC
CGCCACTGTGCCATCTGTGACCCCCTGCTCTATCCCTCCAAGTTCACAGTGAGGGTGGCTCTCA
GGTACATCCTGGCAGGATGGGGGGTGCCCGCAGCATACACTTCGTTATTCCTCTACACAGATGT
GGTAGAGACAAGGCTCAGCCAGTGGCTGGAAGAGATGCCTTGTGTGGGCAGTTGCCAGCTGCTG
CTCAATAAATTTTGGGGCTGGTTAAACTTCCCTTTGTTCTTTGTCCCCTGCCTCATTATGATCA
GCTTGTATGTGAAGATCTTTGTGGTTGCTACCAGACAGGCTCAGCAGATTACCACATTGAGCAA
AAGCCTGGCTGGGGCTGCCAAGCATGAGAGAAAAGCTGCCAAGACCCTGGGCATTGCTGTGGGC
ATATACCTCTTGTGCTGGCTGCCCTTCACCATAGACACGATGGTCGACAGCCTCCTTCACTTTA
TCACACCCCCACTGGTCTTTGACATCTTTATCTGGTTTGCTTACTTCAACTCAGCCTGCAACCC
CATCATCTATGTCTTTTCCTACCAGTGGTTTCGGAAGGCACTGAAACTCACACTGAGCCAGAAG
GTCTTCTCACCGCAGACACGCACTGTTGATTTGTACCAAGAATGATTCCTTCTACTAAATGCAG
GCAAGGAGTAGGACCTCACAGGAAAGATAAGTGGCACTGTGACCGTGGGCTGTGTGGTGTTG

hide sequence

Protein Sequences


Protein RefSeqs	NP_001376456	(Get FASTA)	NCBI Sequence Viewer
	NP_003958	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAC39581	(Get FASTA)	NCBI Sequence Viewer
	AAH69171	(Get FASTA)	NCBI Sequence Viewer
	AAH95541	(Get FASTA)	NCBI Sequence Viewer
	AAI12210	(Get FASTA)	NCBI Sequence Viewer
	AAI12212	(Get FASTA)	NCBI Sequence Viewer
	AAV70123	(Get FASTA)	NCBI Sequence Viewer
	ACP18682	(Get FASTA)	NCBI Sequence Viewer
	EAW48025	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSP00000258034
	ENSP00000258034.2
GenBank Protein	O14804	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_003958 ⟸ NM_003967

- UniProtKB:

Q6NTA8 (UniProtKB/Swiss-Prot), O14804 (UniProtKB/Swiss-Prot), Q5VUQ3 (UniProtKB/Swiss-Prot), Q4VBL1 (UniProtKB/Swiss-Prot), Q2M1V1 (UniProtKB/Swiss-Prot), D8KZS1 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MRAVFIQGAEEHPAAFCYQVNGSCPRTVHTLGIQLVIYLACAAGMLIIVLGNVFVAFAVSYFKA
LHTPTNFLLLSLALADMFLGLLVLPLSTIRSVESCWFFGDFLCRLHTYLDTLFCLTSIFHLCFI
SIDRHCAICDPLLYPSKFTVRVALRYILAGWGVPAAYTSLFLYTDVVETRLSQWLEEMPCVGSC
QLLLNKFWGWLNFPLFFVPCLIMISLYVKIFVVATRQAQQITTLSKSLAGAAKHERKAAKTLGI
AVGIYLLCWLPFTIDTMVDSLLHFITPPLVFDIFIWFAYFNSACNPIIYVFSYQWFRKALKLTL
SQKVFSPQTRTVDLYQE

hide sequence

Ensembl Acc Id:

ENSP00000258034 ⟸ ENST00000258034

RefSeq Acc Id:	NP_001376456 ⟸ NM_001389527
- UniProtKB:	Q6NTA8 (UniProtKB/Swiss-Prot), Q5VUQ3 (UniProtKB/Swiss-Prot), Q4VBL1 (UniProtKB/Swiss-Prot), Q2M1V1 (UniProtKB/Swiss-Prot), O14804 (UniProtKB/Swiss-Prot), D8KZS1 (UniProtKB/Swiss-Prot)

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O14804-F1-model_v2	AlphaFold	O14804	1-337	view protein structure

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	HGNC:30236	AgrOrtholog
COSMIC	TAAR5	COSMIC
Ensembl Genes	ENSG00000135569	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENST00000258034	ENTREZGENE
	ENST00000258034.4	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot
GTEx	ENSG00000135569	GTEx
HGNC ID	HGNC:30236	ENTREZGENE
Human Proteome Map	TAAR5	Human Proteome Map
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot
	TAAR	UniProtKB/Swiss-Prot
	TAAR_fam	UniProtKB/Swiss-Prot
KEGG Report	hsa:9038	UniProtKB/Swiss-Prot
NCBI Gene	9038	ENTREZGENE
OMIM	607405	OMIM
PANTHER	HISTAMINE RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot
	TRACE AMINE-ASSOCIATED RECEPTOR 5	UniProtKB/Swiss-Prot
Pfam	7tm_1	UniProtKB/Swiss-Prot
PharmGKB	PA142670843	PharmGKB
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot
	TRACEAMINER	UniProtKB/Swiss-Prot
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot
UniProt	D8KZS1	ENTREZGENE
	O14804	ENTREZGENE
	Q2M1V1	ENTREZGENE
	Q4VBL1	ENTREZGENE
	Q5VUQ3	ENTREZGENE
	Q6NTA8	ENTREZGENE
	TAAR5_HUMAN	UniProtKB/Swiss-Prot
UniProt Secondary	D8KZS1	UniProtKB/Swiss-Prot
	Q2M1V1	UniProtKB/Swiss-Prot
	Q4VBL1	UniProtKB/Swiss-Prot
	Q5VUQ3	UniProtKB/Swiss-Prot
	Q6NTA8	UniProtKB/Swiss-Prot

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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