Pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) - Rat Genome Database
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Gene: Pik3cb (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) Mus musculus
Analyze
Symbol: Pik3cb
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
RGD ID: 737058
MGI Page MGI
Description: Exhibits 1-phosphatidylinositol-3-kinase activity and insulin receptor substrate binding activity. Involved in several processes, including angiogenesis involved in wound healing; embryonic cleavage; and homophilic cell adhesion via plasma membrane adhesion molecules. Predicted to localize to several cellular components, including brush border membrane; midbody; and nuclear lumen. Is expressed in several structures, including early embryo; face; genitourinary system; respiratory system; and spleen. Human ortholog(s) of this gene implicated in glioblastoma multiforme; prostate adenocarcinoma; prostate cancer; and type 2 diabetes mellitus. Orthologous to human PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta); PARTICIPATES IN epidermal growth factor/neuregulin signaling pathway; FasL mediated signaling pathway; phosphatidylinositol 3-kinase class I signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110001J02Rik; AI447572; MGC150132; p110be; p110beta; phosphatidylinositol 3-kinase, catalytic, beta polypeptide; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; PI3-kinase subunit beta; PI3K-beta; PI3Kbeta; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm12978  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39998,920,455 - 99,022,264 (-)NCBIGRCm39mm39
GRCm38999,038,402 - 99,140,235 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,036,654 - 99,140,621 (-)EnsemblGRCm38mm10GRCm38
MGSCv37998,938,821 - 99,040,630 (-)NCBIGRCm37mm9NCBIm37
MGSCv36998,847,754 - 98,949,439 (-)NCBImm8
Celera998,576,088 - 98,662,033 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal cell physiology  (IAGP)
abnormal epidermis suprabasal layer morphology  (IAGP)
abnormal platelet physiology  (IAGP)
decreased birth body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating cholesterol level  (IAGP)
decreased circulating creatinine level  (IEA)
decreased circulating triglyceride level  (IAGP)
decreased embryo size  (IAGP)
decreased fibroblast proliferation  (IAGP)
decreased heart rate  (IEA)
decreased heart weight  (IAGP)
decreased liver glycogen level  (IAGP)
decreased lumbar vertebrae number  (IEA)
decreased mammary gland tumor incidence  (IAGP)
decreased physiological sensitivity to xenobiotic  (IAGP)
decreased platelet aggregation  (IAGP)
decreased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
decreased tumor growth/size  (IAGP)
embryonic lethality before implantation, incomplete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
impaired gluconeogenesis  (IAGP)
impaired glucose tolerance  (IAGP)
increased circulating glucose level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating leptin level  (IAGP)
increased hemoglobin content  (IEA)
increased insulin secretion  (IAGP)
increased lung weight  (IAGP)
increased mean corpuscular hemoglobin  (IEA)
increased skin hamartoma incidence  (IAGP)
insulin resistance  (IAGP)
lethality throughout fetal growth and development, incomplete penetrance  (IAGP)
pancreatic islet hyperplasia  (IAGP)
postnatal growth retardation  (IAGP)
preweaning lethality, complete penetrance  (IEA)
pulmonary fibrosis  (IAGP)
skin lesions  (IAGP)
thick skin  (IAGP)
weight loss  (IAGP)
References

References - curated
1. An HJ, etal., J Pathol. 2007 Jun;212(2):161-9.
2. Chen H, etal., J Neurooncol. 2011 Aug;104(1):155-67. doi: 10.1007/s11060-010-0492-2. Epub 2010 Dec 29.
3. Edgar KA, etal., Cancer Res. 2010 Feb 1;70(3):1164-72. doi: 10.1158/0008-5472.CAN-09-2525. Epub 2010 Jan 26.
4. Hirsch E, etal., J Endocrinol. 2007 Aug;194(2):243-56.
5. Jackson SP, etal., Nat Med. 2005 May;11(5):507-14. Epub 2005 Apr 17.
6. Karlsson T, etal., Oncotarget. 2017 Jan 17;8(3):3881-3894. doi: 10.18632/oncotarget.13989.
7. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
8. Kim YB, etal., Diabetes. 2002 Feb;51(2):443-8.
9. MGD and Homologene mouse data transfer
10. MGD data from the GO Consortium
11. MGD IEA
12. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. Pipeline to import KEGG annotations from KEGG into RGD
14. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. RGD automated import pipeline
16. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. RGD automated import pipeline for gene-chemical interactions
18. Song L, etal., Mol Med Rep. 2016 Feb;13(2):1204-10. doi: 10.3892/mmr.2015.4661. Epub 2015 Dec 9.
19. Varghese RT, etal., Oncotarget. 2016 Mar 4. doi: 10.18632/oncotarget.7917.
20. Wee S, etal., Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):13057-62. doi: 10.1073/pnas.0802655105. Epub 2008 Aug 28.
21. Wen F, etal., Int J Clin Exp Pathol. 2014 Oct 15;7(11):8295-303. eCollection 2014.
22. Yu WD, etal., World J Gastroenterol. 2014 Nov 21;20(43):16258-67. doi: 10.3748/wjg.v20.i43.16258.
23. Zhu Q, etal., Oncogene. 2008 Jul 31;27(33):4569-79. doi: 10.1038/onc.2008.91. Epub 2008 Mar 31.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11919689   PMID:12477932   PMID:12869549   PMID:12870650   PMID:12904583   PMID:14379171   PMID:14610273   PMID:14681479  
PMID:15102471   PMID:15496927   PMID:15713620   PMID:16141072   PMID:16141073   PMID:16467569   PMID:16514418   PMID:16625210   PMID:17579043   PMID:17673465   PMID:17846664   PMID:17908814  
PMID:17920279   PMID:18187452   PMID:18285463   PMID:18287559   PMID:18367611   PMID:18449193   PMID:18544649   PMID:18558630   PMID:18590694   PMID:18594509   PMID:18780892   PMID:18799693  
PMID:18988856   PMID:19033389   PMID:19047410   PMID:19416922   PMID:19509054   PMID:19515725   PMID:19597047   PMID:19815551   PMID:19834495   PMID:19883613   PMID:19940148   PMID:20053680  
PMID:20065293   PMID:20368419   PMID:20534477   PMID:20534549   PMID:20665729   PMID:20697350   PMID:20699475   PMID:21059846   PMID:21255018   PMID:21257963   PMID:21267068   PMID:21362552  
PMID:21367821   PMID:21383062   PMID:21464441   PMID:21474070   PMID:21487106   PMID:21540297   PMID:21677750   PMID:21731673   PMID:21873635   PMID:21912691   PMID:21917798   PMID:22074824  
PMID:22084313   PMID:22106345   PMID:22150431   PMID:22539774   PMID:22802530   PMID:22984590   PMID:23029326   PMID:23051731   PMID:23216754   PMID:23252604   PMID:23258246   PMID:23330804  
PMID:23434372   PMID:23568272   PMID:23584990   PMID:23606281   PMID:23706742   PMID:23873941   PMID:24131925   PMID:24565867   PMID:24691033   PMID:24737887   PMID:24903091   PMID:24952961  
PMID:24991009   PMID:25139353   PMID:25269483   PMID:25311989   PMID:25327288   PMID:25398937   PMID:25406378   PMID:25605332   PMID:25618408   PMID:25921527   PMID:25960397   PMID:26132308  
PMID:26442967   PMID:26896753   PMID:27022680   PMID:27304846   PMID:27531651   PMID:27700986   PMID:27965101   PMID:29212950   PMID:29902570   PMID:30201980   PMID:30496354   PMID:30568254  
PMID:31409694   PMID:32290105   PMID:32325033   PMID:32553114   PMID:32879446  


Genomics

Comparative Map Data
Pik3cb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39998,920,455 - 99,022,264 (-)NCBIGRCm39mm39
GRCm38999,038,402 - 99,140,235 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl999,036,654 - 99,140,621 (-)EnsemblGRCm38mm10GRCm38
MGSCv37998,938,821 - 99,040,630 (-)NCBIGRCm37mm9NCBIm37
MGSCv36998,847,754 - 98,949,439 (-)NCBImm8
Celera998,576,088 - 98,662,033 (-)NCBICelera
Cytogenetic Map9E3.3NCBI
PIK3CB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3138,652,698 - 138,834,928 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl3138,652,699 - 138,834,938 (-)EnsemblGRCh38hg38GRCh38
GRCh383138,652,698 - 138,834,928 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373138,371,540 - 138,553,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363139,856,921 - 139,960,875 (-)NCBINCBI36hg18NCBI36
Build 343139,856,928 - 139,960,883NCBI
Celera3136,799,538 - 136,904,134 (-)NCBI
Cytogenetic Map3q22.3NCBI
HuRef3135,746,166 - 135,853,444 (-)NCBIHuRef
CHM1_13138,335,402 - 138,442,207 (-)NCBICHM1_1
Pik3cb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08107,275,849 - 107,381,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8107,275,725 - 107,380,933 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08106,700,158 - 106,788,063 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48103,886,682 - 103,957,112 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18103,906,136 - 103,976,567 (-)NCBI
Celera899,000,434 - 99,072,100 (-)NCBICelera
Cytogenetic Map8q31NCBI
Pik3cb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955501259,645 - 379,909 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955501251,829 - 381,255 (+)NCBIChiLan1.0ChiLan1.0
PIK3CB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13143,288,563 - 143,431,314 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3143,288,563 - 143,431,314 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03135,685,120 - 135,867,096 (-)NCBIMhudiblu_PPA_v0panPan3
PIK3CB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2334,836,540 - 34,993,939 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12334,832,661 - 34,955,410 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Pik3cb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936540907,118 - 1,041,814 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIK3CB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1379,425,812 - 79,610,840 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11379,427,033 - 79,610,840 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21387,042,709 - 87,067,016 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIK3CB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11551,705,585 - 51,885,848 (+)NCBI
ChlSab1.1 Ensembl1551,775,733 - 51,889,238 (+)Ensembl
Pik3cb
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473015,226,786 - 15,399,097 (-)NCBI

Position Markers
AI447572  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38999,038,549 - 99,038,712UniSTSGRCm38
MGSCv37998,938,968 - 98,939,131UniSTSGRCm37
Celera998,576,235 - 98,576,398UniSTS
Cytogenetic Map9E4UniSTS
Whitehead/MRC_RH91009.81UniSTS
RH125348  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38999,138,252 - 99,138,387UniSTSGRCm38
MGSCv37999,038,671 - 99,038,806UniSTSGRCm37
Celera998,677,930 - 98,678,065UniSTS
Cytogenetic Map9E3.3UniSTS
Cytogenetic Map9E4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12904947Tammq7_mtibialis anterior muscle mass QTL 7 (mouse)991683173124595110Mouse
13463474Hbbcq5_mhemoglobin concentration QTL 5 (mouse)991641084124595110Mouse
10054068El8_mepilepsy 8 (mouse)Not determined972977005106977152Mouse
1357461Idd2_minsulin dependent diabetes susceptibility 2 (mouse)Not determined982910333116910428Mouse
11081166Psl5_mpromotion susceptibility QTL 5 (mouse)994981301112872929Mouse
1301192Skts6_mskin tumor susceptibility 6 (mouse)Not determined978640645112640755Mouse
13463477Rbc9_mred blood cell count 9 (mouse)991641084124595110Mouse
1357635Splq4_mspleen weight QTL 4 (mouse)Not determined963332429120362868Mouse
1301241Renf1_mrenal failure 1 (mouse)Not determined95212317899910428Mouse
1300549Bbaa17_mB. burgdorferi-associated arthritis 17 (mouse)Not determined986230401120230530Mouse
1558767Skmw11_mskeletal muscle weight 11 (mouse)Not determined991641084124595110Mouse
10045638Heal29_mwound healing/regeneration 29 (mouse)Not determined967124167101124167Mouse
12910773Splic3_mspleen iron content 3 (mouse)991413879124595110Mouse
11537364Cnes5_mC. neoformans susceptibility locus 5 (mouse)996917590124595110Mouse
14746992Manh67_mmandible shape 67 (mouse)994036768124595110Mouse
4141545Tailaq2_mtail length adjusted QTL 2 (mouse)Not determined63332429120362868Mouse
1357610Vtbt8_mvertebral trabecular bone trait 8 (mouse)Not determined968897510102897652Mouse
1301732Char1_mP. chabaudi malaria resistance QTL 1 (mouse)Not determined981798268115798392Mouse
1301407Rapop2_mradiation-induced apoptosis 2 (mouse)Not determined976535936110536130Mouse
1301725Lifespan1_mlife span 1 (mouse)Not determined974368177108368325Mouse
12910770Splic1_mspleen iron content 1 (mouse)991413879124595110Mouse
1301573Etohcta8_methanol conditioned taste aversion 8 (mouse)Not determined972977005106977152Mouse
12904937Edlmmq9_mextensor digitorum longus muscle mass QTL 9 (mouse)991683173124595110Mouse
4141833W10q13_mweight 10 weeks QTL 13 (mouse)Not determined63332429120362868Mouse
13463478Mchq18_mmean corpuscular hemoglobin QTL 18 (mouse)991641084124595110Mouse
13207569Tcq13_mtotal cholesterol QTL 13 (mouse)959990000109260000Mouse
1301636Lith5_mlithogenic gene 5 (mouse)Not determined966207024100207122Mouse
1302001Bdln5_mbody length 5 (mouse)Not determined993762590124595110Mouse
10054492El7_mepilepsy 7 (mouse)Not determined975775364114474379Mouse
12910772Lvic6_mliver iron content 6 (mouse)991413879124595110Mouse
1302103Dob2_mdietary obesity 2 (mouse)Not determined986239845120289624Mouse
10766454Char10_mP. chabaudi malaria resistance QTL 10 (mouse)982910333116910428Mouse
1357657Pymr_mPlasmodium yoelli malaria resistance (mouse)Not determined989977005118938021Mouse
10412242Alpq8_malcohol preference QTL 8 (mouse)Not determined989284925123284925Mouse
1301302Pas4_mpulmonary adenoma susceptibility 4 (mouse)Not determined969239845103239920Mouse
12904961Gmmq7_mgastrocnemius muscle mass QTL 7 (mouse)991683173124595110Mouse
13463480Mchcq2_mmean corpuscular hemoglobin concentration QTL 2 (mouse)991641084124595110Mouse
10401247Bglu14_mblood glucose level 14 (mouse)Not determined979397810113397888Mouse
1301621Hpic1_mhaloperidol-induced catalepsy 1 (mouse)Not determined969546513103546645Mouse
1300884Sluc11_msusceptibility to lung cancer 11 (mouse)Not determined982910333116910428Mouse
1302065El1_mepilepsy 1 (mouse)Not determined975775364114474379Mouse
18182932Metl3_mmetabolite locus 3, N-acetylglutamate (mouse)989563342123563342Mouse
1301869Tbbmd4_mtotal body bone mineral density 4 (mouse)Not determined976117105101528921Mouse
11251716Siim2_mstress induced immobility 2 (mouse)986748483120748483Mouse
12880422V25Dq6_mvitamin D inactive form serum level QTL 6 (mouse)987800000121800000Mouse
1301487Nociq1_mnociceptive sensitivity inflammatory QTL 1 (mouse)Not determined984528818118528921Mouse
1301924Bmd10_mbone mineral density 10 (mouse)Not determined968897510102897652Mouse
10412180Msam3_mmuscle, skeletal, activity measure 3 (mouse)Not determined985897510108641186Mouse
1301649Psl1_mpromotion susceptibility QTL 1 (mouse)Not determined989412277123412396Mouse
1301484Bwq6_mbody weight (mouse)Not determined993762590124595110Mouse
13463475Hctq7_mhematocrit QTL 7 (mouse)991641084124595110Mouse
4141224Dxmod_mdoxorubicin nephropathy modifier (mouse)Not determined49541121101528921Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1144
Count of miRNA genes:524
Interacting mature miRNAs:613
Transcripts:ENSMUST00000035037, ENSMUST00000124723, ENSMUST00000136965
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000035037   ⟹   ENSMUSP00000035037
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,036,654 - 99,140,087 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124723   ⟹   ENSMUSP00000121466
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,101,350 - 99,140,621 (-)Ensembl
RefSeq Acc Id: ENSMUST00000136965   ⟹   ENSMUSP00000138346
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl999,038,401 - 99,139,925 (-)Ensembl
RefSeq Acc Id: NM_029094   ⟹   NP_083370
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39998,920,455 - 99,022,264 (-)NCBI
GRCm38999,038,402 - 99,140,211 (-)NCBI
MGSCv37998,938,821 - 99,040,630 (-)RGD
Celera998,576,088 - 98,662,033 (-)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242829   ⟹   XP_011241131
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39998,920,456 - 99,021,969 (-)NCBI
GRCm38999,038,403 - 99,139,932 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011242830   ⟹   XP_011241132
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39998,920,456 - 99,021,730 (-)NCBI
GRCm38999,038,407 - 99,139,677 (-)NCBI
Sequence:
RefSeq Acc Id: XM_030244688   ⟹   XP_030100548
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39998,920,456 - 99,022,227 (-)NCBI
GRCm38999,038,403 - 99,140,235 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_083370   ⟸   NM_029094
- UniProtKB: Q8BTI9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011241132   ⟸   XM_011242830
- Peptide Label: isoform X1
- UniProtKB: Q8BTI9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011241131   ⟸   XM_011242829
- Peptide Label: isoform X1
- UniProtKB: Q8BTI9 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_030100548   ⟸   XM_030244688
- Peptide Label: isoform X2
RefSeq Acc Id: ENSMUSP00000121466   ⟸   ENSMUST00000124723
RefSeq Acc Id: ENSMUSP00000035037   ⟸   ENSMUST00000035037
RefSeq Acc Id: ENSMUSP00000138346   ⟸   ENSMUST00000136965
Protein Domains
C2 PI3K-type   PI3K-ABD   PI3K-RBD   PI3K/PI4K   PIK helical

Promoters
RGD ID:6844953
Promoter ID:MM_KWN:58480
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:NM_029094,   OTTMUST00000049862,   OTTMUST00000049863
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36999,040,586 - 99,041,086 (-)MPROMDB
RGD ID:8670548
Promoter ID:EPDNEW_M13305
Type:initiation region
Name:Pik3cb_2
Description:Mus musculus phosphatidylinositol-4,5-bisphosphate 3-kinase catalyticsubunit beta , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13306  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38999,140,069 - 99,140,129EPDNEW
RGD ID:8670550
Promoter ID:EPDNEW_M13306
Type:initiation region
Name:Pik3cb_1
Description:Mus musculus phosphatidylinositol-4,5-bisphosphate 3-kinase catalyticsubunit beta , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M13305  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38999,140,193 - 99,140,253EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1922019 AgrOrtholog
Ensembl Genes ENSMUSG00000032462 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035037 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000121466 UniProtKB/TrEMBL
  ENSMUSP00000138346 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000035037 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000124723 UniProtKB/TrEMBL
  ENSMUST00000136965 UniProtKB/TrEMBL
Gene3D-CATH 1.10.1070.11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_cat_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3/4_kinase_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_accessory_dom UniProtKB/TrEMBL
  PI3K_accessory_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_adapt-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_Ras-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Kbeta_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI_Kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PInositide-3_kin_accessory_dom UniProtKB/Swiss-Prot
  Ubiquitin-like_domsf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:74769 UniProtKB/Swiss-Prot
MGD MGI:1922019 ENTREZGENE
NCBI Gene 74769 ENTREZGENE
PANTHER PTHR10048 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PI3_PI4_kinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Pik3cb PhenoGen
PROSITE PI3_4_KINASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3_4_KINASE_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_ABD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_RBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PIK_HELICAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PI3K_C2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_p85B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3K_rbd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Ka UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PI3Kc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54236 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Mm.213128 ENTREZGENE
UniProt A0JNZ1_MOUSE UniProtKB/TrEMBL
  D3Z2Z7_MOUSE UniProtKB/TrEMBL
  PK3CB_MOUSE UniProtKB/Swiss-Prot
  Q3TNJ8_MOUSE UniProtKB/TrEMBL
  Q8BTI9 ENTREZGENE
  Q8CFF1_MOUSE UniProtKB/TrEMBL
  Q9CTK7_MOUSE UniProtKB/TrEMBL
  S4R1S1_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3U4Q1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-09 Pik3cb  phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta    phosphatidylinositol 3-kinase, catalytic, beta polypeptide  Symbol and/or name change 5135510 APPROVED