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Gene: PIK3CB (phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta) Homo sapiens
Symbol: PIK3CB
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
Description: Exhibits kinase activity. Involved in several processes, including phosphatidylinositol 3-kinase signaling; positive regulation of neutrophil apoptotic process; and regulation of cell-matrix adhesion. Localizes to midbody; nucleolus; and nucleoplasm. Implicated in glioblastoma multiforme; prostate adenocarcinoma; and prostate cancer. Biomarker of benign rectal neoplasm; endometrial cancer; glioblastoma multiforme; prostate cancer; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DKFZp779K1237; MGC133043; P110BETA; phosphatidylinositol 3-kinase, catalytic subunit, beta isoform; phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; phosphoinositide-3-kinase, catalytic, beta polypeptide; PI3-kinase p110 subunit beta; PI3-kinase subunit beta; PI3K; PI3K-beta; PI3KBETA; PIK3C1; PtdIns-3-kinase p110; ptdIns-3-kinase subunit beta; ptdIns-3-kinase subunit p110-beta
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl3138,652,698 - 138,834,928 (-)EnsemblGRCh38hg38GRCh38
GRCh38 Ensembl3138,652,699 - 138,834,938 (-)EnsemblGRCh38hg38GRCh38
GRCh383138,652,698 - 138,834,928 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373138,371,540 - 138,553,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363139,856,921 - 139,960,875 (-)NCBINCBI36hg18NCBI36
Build 343139,856,928 - 139,960,883NCBI
Celera3136,799,538 - 136,904,134 (-)NCBI
Cytogenetic Map3q22.3NCBI
HuRef3135,746,166 - 135,853,444 (-)NCBIHuRef
CHM1_13138,335,402 - 138,442,207 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PIK3CB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 732496
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.