Wwc2 (WW and C2 domain containing 2) - Rat Genome Database

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Gene: Wwc2 (WW and C2 domain containing 2) Rattus norvegicus
Analyze
Symbol: Wwc2
Name: WW and C2 domain containing 2
RGD ID: 1559427
Description: Predicted to enable kinase binding activity and molecular adaptor activity. Predicted to be involved in several processes, including negative regulation of hippo signaling; negative regulation of organ growth; and negative regulation of transcription by RNA polymerase II. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Orthologous to human WWC2 (WW and C2 domain containing 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC498630; RGD1559427; similar to BH3-only member B protein; WW, C2 and coiled-coil domain containing 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21644,258,372 - 44,421,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1644,258,372 - 44,421,812 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1649,663,863 - 49,828,168 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01653,024,440 - 53,188,739 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01648,300,572 - 48,465,778 (+)NCBIRnor_WKY
Rnor_6.01647,368,768 - 47,533,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1647,368,768 - 47,533,816 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01647,091,900 - 47,254,470 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41647,456,709 - 47,624,245 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1642,271,804 - 42,433,958 (+)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA)
cytosol  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:24682284  


Genomics

Comparative Map Data
Wwc2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21644,258,372 - 44,421,815 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1644,258,372 - 44,421,812 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1649,663,863 - 49,828,168 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01653,024,440 - 53,188,739 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01648,300,572 - 48,465,778 (+)NCBIRnor_WKY
Rnor_6.01647,368,768 - 47,533,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1647,368,768 - 47,533,816 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01647,091,900 - 47,254,470 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41647,456,709 - 47,624,245 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1642,271,804 - 42,433,958 (+)NCBICelera
Cytogenetic Map16q11NCBI
WWC2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384183,099,257 - 183,320,777 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4183,099,257 - 183,320,777 (+)EnsemblGRCh38hg38GRCh38
GRCh374184,020,410 - 184,241,930 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364184,257,457 - 184,478,924 (+)NCBINCBI36Build 36hg18NCBI36
Celera4181,354,474 - 181,575,877 (+)NCBICelera
Cytogenetic Map4q35.1NCBI
HuRef4179,780,892 - 180,002,267 (+)NCBIHuRef
CHM1_14183,996,866 - 184,218,376 (+)NCBICHM1_1
T2T-CHM13v2.04186,442,799 - 186,664,233 (+)NCBIT2T-CHM13v2.0
Wwc2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39848,279,117 - 48,443,579 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl848,276,994 - 48,443,959 (-)EnsemblGRCm39 Ensembl
GRCm38847,826,082 - 47,990,544 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl847,823,959 - 47,990,924 (-)EnsemblGRCm38mm10GRCm38
MGSCv37848,912,949 - 49,075,905 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36849,326,412 - 49,489,368 (-)NCBIMGSCv36mm8
Celera850,505,747 - 50,669,369 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
cM Map826.91NCBI
Wwc2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540325,482,601 - 25,627,580 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540325,482,601 - 25,602,412 (-)NCBIChiLan1.0ChiLan1.0
WWC2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14187,597,081 - 187,721,702 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4187,597,081 - 187,721,702 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04175,280,079 - 175,495,156 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
WWC2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11647,014,151 - 47,185,456 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1647,013,943 - 47,185,500 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1647,447,206 - 47,652,095 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01649,237,790 - 49,443,012 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1649,237,582 - 49,443,483 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11647,199,477 - 47,404,477 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01647,813,883 - 48,019,107 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01647,954,522 - 48,159,690 (-)NCBIUU_Cfam_GSD_1.0
Wwc2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494332,242,691 - 32,360,134 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365545,752,038 - 5,899,089 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365545,749,850 - 5,852,874 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WWC2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1544,615,983 - 44,802,786 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11544,615,731 - 44,802,717 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21551,228,437 - 51,415,435 (+)NCBISscrofa10.2Sscrofa10.2susScr3
WWC2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.17129,074,640 - 129,293,372 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl7129,074,847 - 129,290,392 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037109,289,423 - 109,509,168 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Wwc2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476913,829,415 - 14,053,067 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476913,829,319 - 14,058,053 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Wwc2
778 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:823
Count of miRNA genes:331
Interacting mature miRNAs:434
Transcripts:ENSRNOT00000017966
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16144588133Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)1638024580345693Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683223646053497Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683223659492508Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683223659492508Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683223659492508Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683223659492508Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16422760948972724Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16422760960252231Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor depth of invasion (CMO:0001888)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161769679182635055Rat
70215Niddm29Non-insulin dependent diabetes mellitus QTL 293.54blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)161900443575226532Rat
2302057Pia29Pristane induced arthritis QTL 293.60.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)162173597566735975Rat
8694453Bw172Body weight QTL 1728.330.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)162432551369325513Rat
6903294Stl30Serum triglyceride level QTL 302.60.0013blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)162515279370152793Rat
1298529Arunc1Aerobic running capacity QTL 14exercise endurance trait (VT:0002332)maximum distance run on treadmill (CMO:0001406)163195152060148445Rat
1578768Stresp22Stress response QTL 222.8thymus mass (VT:0004954)thymus wet weight (CMO:0000855)163528887080288870Rat
2293690Bss45Bone structure and strength QTL 455.130.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)163775215682752156Rat
2300163Bmd64Bone mineral density QTL 645.30.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)163775215682752156Rat
7205510Activ5Activity QTL 53.780.00028locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)164239634584729064Rat
631833Sach2Saccharin preference QTL 240.01consumption behavior trait (VT:0002069)calculated saccharin drink intake rate (CMO:0001613)164302484250166018Rat

Markers in Region
BF410396  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21644,421,233 - 44,421,473 (+)MAPPERmRatBN7.2
Rnor_6.01647,533,238 - 47,533,477NCBIRnor6.0
Rnor_5.01647,253,892 - 47,254,131UniSTSRnor5.0
RGSC_v3.41647,623,667 - 47,623,906UniSTSRGSC3.4
Celera1642,433,380 - 42,433,619UniSTS
Cytogenetic Map16q11UniSTS
BE107847  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21644,414,014 - 44,414,168 (+)MAPPERmRatBN7.2
Rnor_6.01647,525,812 - 47,525,965NCBIRnor6.0
Rnor_5.01647,246,466 - 47,246,619UniSTSRnor5.0
RGSC_v3.41647,616,448 - 47,616,601UniSTSRGSC3.4
Celera1642,426,161 - 42,426,314UniSTS
RH 3.4 Map16438.5UniSTS
Cytogenetic Map16q11UniSTS
BF390151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21644,273,447 - 44,273,610 (+)MAPPERmRatBN7.2
Rnor_6.01647,384,163 - 47,384,325NCBIRnor6.0
Rnor_5.01647,106,397 - 47,106,559UniSTSRnor5.0
RGSC_v3.41647,472,870 - 47,473,032UniSTSRGSC3.4
Celera1642,286,617 - 42,286,779UniSTS
RH 3.4 Map16439.11UniSTS
Cytogenetic Map16q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 26 8 6 5 6 58 35 41 11
Low 3 17 49 35 14 35 8 10 16 8
Below cutoff 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000017966   ⟹   ENSRNOP00000017966
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1644,258,372 - 44,421,812 (+)Ensembl
Rnor_6.0 Ensembl1647,368,768 - 47,533,816 (+)Ensembl
RefSeq Acc Id: NM_001109111   ⟹   NP_001102581
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21644,258,372 - 44,421,812 (+)NCBI
Rnor_6.01647,368,768 - 47,533,816 (+)NCBI
Rnor_5.01647,091,900 - 47,254,470 (+)NCBI
RGSC_v3.41647,456,709 - 47,624,245 (+)RGD
Celera1642,271,804 - 42,433,958 (+)RGD
Sequence:
RefSeq Acc Id: XM_039094770   ⟹   XP_038950698
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21644,259,086 - 44,421,815 (+)NCBI
RefSeq Acc Id: XM_039094771   ⟹   XP_038950699
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21644,355,719 - 44,421,815 (+)NCBI
RefSeq Acc Id: XM_039094772   ⟹   XP_038950700
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21644,351,091 - 44,421,815 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001102581 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950698 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950699 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950700 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL78921 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001102581   ⟸   NM_001109111
- UniProtKB: D4AEJ5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000017966   ⟸   ENSRNOT00000017966
RefSeq Acc Id: XP_038950698   ⟸   XM_039094770
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038950700   ⟸   XM_039094772
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038950699   ⟸   XM_039094771
- Peptide Label: isoform X2
Protein Domains
C2   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AEJ5-F1-model_v2 AlphaFold D4AEJ5 1-1194 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700086
Promoter ID:EPDNEW_R10610
Type:initiation region
Name:Wwc2_1
Description:WW and C2 domain containing 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01647,369,186 - 47,369,246EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1559427 AgrOrtholog
BioCyc Gene G2FUF-11419 BioCyc
Ensembl Genes ENSRNOG00000013248 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000017966 ENTREZGENE
  ENSRNOP00000017966.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017966 ENTREZGENE
  ENSRNOT00000017966.6 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2_WWC UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
KEGG Report rno:498630 UniProtKB/TrEMBL
NCBI Gene 498630 ENTREZGENE
Pfam PF00397 UniProtKB/TrEMBL
PhenoGen Wwc2 PhenoGen
PROSITE PS50004 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART SM00456 UniProtKB/TrEMBL
Superfamily-SCOP SSF49562 UniProtKB/TrEMBL
  WW_Rsp5_WWP UniProtKB/TrEMBL
UniProt D4AEJ5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Wwc2  WW and C2 domain containing 2  Wwc2  WW, C2 and coiled-coil domain containing 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Wwc2  WW, C2 and coiled-coil domain containing 2  RGD1559427_predicted  similar to BH3-only member B protein (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1559427_predicted  similar to BH3-only member B protein (predicted)  LOC498630  similar to BH3-only member B protein  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC498630  similar to BH3-only member B protein      Symbol and Name status set to provisional 70820 PROVISIONAL