Gene: Wwc2 (WW and C2 domain containing 2) Rattus norvegicus
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Symbol: Wwc2
Name: WW and C2 domain containing 2
Description: ENCODES a protein that exhibits kinase binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN negative regulation of hippo signaling (ortholog); negative regulation of organ growth (ortholog); negative regulation of transcription by RNA polymerase II (ortholog); ASSOCIATED WITH long QT syndrome (ortholog); FOUND IN cytosol (ortholog); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide
AGR Description: Predicted to have kinase binding activity; predicted to be involved in negative regulation of hippo signaling, negative regulation of organ growth, and negative regulation of transcription by RNA polymerase II; predicted to localize to the cytosol; orthologous to human WWC2 (WW and C2 domain containing 2).
Merged Description: Predicted to have kinase binding activity; predicted to be involved in negative regulation of hippo signaling, negative regulation of organ growth, and negative regulation of transcription by RNA polymerase II; predicted to localize to the cytosol; orthologous to human WWC2 (WW and C2 domain containing 2); INTERACTS WITH 17beta-estradiol; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC498630; RGD1559427; similar to BH3-only member B protein; WW, C2 and coiled-coil domain containing 2
Orthologs:
Homo sapiens (human) : WWC2 (WW and C2 domain containing 2)  HGNC  Alliance
Mus musculus (house mouse) : Wwc2 (WW, C2 and coiled-coil domain containing 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wwc2 (WW and C2 domain containing 2)
Pan paniscus (bonobo/pygmy chimpanzee) : WWC2 (WW and C2 domain containing 2)
Canis lupus familiaris (dog) : WWC2 (WW and C2 domain containing 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wwc2 (WW and C2 domain containing 2)
Sus scrofa (pig) : WWC2 (WW and C2 domain containing 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01647,368,768 - 47,533,816 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01647,091,900 - 47,254,470 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41647,456,709 - 47,624,245 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1642,271,804 - 42,433,958 (+)NCBICelera
Cytogenetic Map16q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Wwc2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1559427
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.