Apoa5 (apolipoprotein A5) - Rat Genome Database

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Gene: Apoa5 (apolipoprotein A5) Rattus norvegicus
Analyze
Symbol: Apoa5
Name: apolipoprotein A5
RGD ID: 70903
Description: Predicted to enable several functions, including enzyme activator activity; heparin binding activity; and lipase binding activity. Involved in animal organ regeneration; lipid transport; and response to hormone. Located in extracellular space. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in cerebral infarction; coronary artery disease; familial hyperlipidemia (multiple); and type 2 diabetes mellitus. Orthologous to human APOA5 (apolipoprotein A5); PARTICIPATES IN lipoprotein metabolic pathway; eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 17alpha-ethynylestradiol; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: apo-AV; apoA-V; apolipoprotein A-V; MGC108612; regeneration-associated protein 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2846,561,180 - 46,563,818 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,561,229 - 46,563,816 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx852,062,457 - 52,065,145 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0850,341,227 - 50,343,915 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0848,205,503 - 48,208,191 (+)NCBIRnor_WKY
Rnor_6.0850,559,079 - 50,561,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,559,126 - 50,561,736 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,185,041 - 49,187,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4849,253,538 - 49,255,777 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1849,265,341 - 49,267,579 (+)NCBI
Celera846,142,946 - 46,145,584 (+)NCBICelera
Cytogenetic Map8q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
6-(4-chlorophenyl)imidazo[2,1-b][1,3]thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
benzo[a]pyrene  (ISO)
beta-hexachlorocyclohexane  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buta-1,3-diene  (ISO)
C60 fullerene  (EXP)
CGP 52608  (ISO)
clofibrate  (EXP,ISO)
clozapine  (EXP)
cobalt dichloride  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
dicrotophos  (ISO)
endosulfan  (EXP)
epoxiconazole  (ISO)
farnesol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
genistein  (ISO)
gentamycin  (EXP)
glycidol  (EXP)
graphite  (EXP)
GW 4064  (ISO)
GW 7647  (ISO)
hydrazine  (ISO)
hydrogen peroxide  (ISO)
isoniazide  (EXP)
L-methionine  (ISO)
menadione  (ISO)
metformin  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
O-methyleugenol  (ISO)
oleic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluoroheptanoic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorohexanoic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
propiconazole  (ISO)
quercetin  (ISO)
rotenone  (EXP)
silibinin  (EXP)
sodium arsenite  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zidovudine  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
2. Association of APOA5 -1131T>C and S19W gene polymorphisms with both mild hypertriglyceridemia and hyperchylomicronemia in type 2 diabetic patients. Charriere S, etal., Clin Chim Acta. 2008 Aug;394(1-2):99-103. Epub 2008 Apr 27.
3. SINGLE NUCLEOTIDE POLYMORPHISMS THAT INFLUENCE LIPID METABOLISM: Interaction with Dietary Factors. Corella D and Ordovas JM, Annu Rev Nutr. 2005;25:341-90.
4. The APOA5 Trp19 allele is associated with metabolic syndrome via its association with plasma triglycerides. Dallongeville J, etal., BMC Med Genet. 2008 Sep 12;9:84.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. T-1131-->C polymorphism within the apolipoprotein AV gene in hypertriglyceridemic individuals. Horinek A, etal., Atherosclerosis. 2003 Apr;167(2):369-70.
7. Atorvastatin and fenofibrate increase apolipoprotein AV and decrease triglycerides by up-regulating peroxisome proliferator-activated receptor-alpha. Huang XS, etal., Br J Pharmacol. 2009 Aug 19.
8. Apolipoprotein A5 and hypertriglyceridemia in Prague hypertriglyceridemic rats. Kadlecova M, etal., Physiol Res. 2006;55(4):373-9. Epub 2005 Oct 17.
9. APOA5 gene polymorphism modulates levels of triglyceride, HDL cholesterol and FERHDL but is not a risk factor for coronary artery disease. Lee KW, etal., Atherosclerosis. 2004 Sep;176(1):165-72.
10. Polymorphism of apolipoprotein A5 is a risk factor for cerebral infarction in type 2 diabetes. Li X, etal., J Huazhong Univ Sci Technolog Med Sci. 2008 Dec;28(6):653-6. Epub 2008 Dec 24.
11. Gene Data Set MGD Curation, June 12, 2002
12. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
15. An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing. Pennacchio LA, etal., Science 2001 Oct 5;294(5540):169-73.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. Thyroid hormone regulates the hypotriglyceridemic gene APOA5. Prieur X, etal., J Biol Chem. 2005 Jul 29;280(30):27533-43. Epub 2005 Jun 7.
18. Postprandial increase of plasma apoAV concentrations in Type 2 diabetic patients. Pruneta-Deloche V, etal., Atherosclerosis. 2005 Aug;181(2):403-5. Epub 2005 Feb 17.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Comprehensive gene review and curation RGD comprehensive gene curation
23. Polymorphism in the promoter region of the apolipoprotein A5 gene is associated with an increased susceptibility for coronary artery disease. Szalai C, etal., Atherosclerosis. 2004 Mar;173(1):109-14.
24. Apolipoprotein A-V: a novel apolipoprotein associated with an early phase of liver regeneration. van der Vliet HN, etal., J Biol Chem 2001 Nov 30;276(48):44512-20.
25. Association of APOA5 c.553G>T polymorphism with type 2 diabetes mellitus in a Chinese population. Zhai G, etal., Clin Chem Lab Med. 2006;44(11):1313-6.
26. [Association of apolipoprotein A5 gene -1131T/C polymorphism with lipid metabolism and insulin resistance in patients with type II diabetes mellitus] Zhai GH, etal., Yi Chuan. 2007 May;29(5):541-6.
Additional References at PubMed
PMID:12417525   PMID:12477932   PMID:12810715   PMID:14729863   PMID:15178420   PMID:15528295   PMID:15878877   PMID:16166565   PMID:16570166   PMID:16806135   PMID:17142127   PMID:17326667  
PMID:18450648   PMID:18635818   PMID:19121291   PMID:19910685   PMID:20047745   PMID:21092650   PMID:21115968   PMID:25938357   PMID:26505974   PMID:32602585  


Genomics

Comparative Map Data
Apoa5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2846,561,180 - 46,563,818 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl846,561,229 - 46,563,816 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx852,062,457 - 52,065,145 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0850,341,227 - 50,343,915 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0848,205,503 - 48,208,191 (+)NCBIRnor_WKY
Rnor_6.0850,559,079 - 50,561,720 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl850,559,126 - 50,561,736 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0849,185,041 - 49,187,682 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4849,253,538 - 49,255,777 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1849,265,341 - 49,267,579 (+)NCBI
Celera846,142,946 - 46,145,584 (+)NCBICelera
Cytogenetic Map8q22NCBI
APOA5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811116,789,367 - 116,792,420 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11116,789,367 - 116,792,420 (-)EnsemblGRCh38hg38GRCh38
GRCh3711116,660,083 - 116,663,136 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611116,165,296 - 116,167,794 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411116,165,296 - 116,167,794NCBI
Celera11113,815,476 - 113,818,526 (-)NCBICelera
Cytogenetic Map11q23.3NCBI
HuRef11112,592,079 - 112,595,129 (-)NCBIHuRef
CHM1_111116,544,726 - 116,547,776 (-)NCBICHM1_1
T2T-CHM13v2.011116,803,991 - 116,807,044 (-)NCBIT2T-CHM13v2.0
Apoa5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39946,179,906 - 46,183,219 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl946,179,931 - 46,183,217 (+)EnsemblGRCm39 Ensembl
GRCm38946,268,608 - 46,271,921 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl946,268,633 - 46,271,919 (+)EnsemblGRCm38mm10GRCm38
MGSCv37946,076,691 - 46,080,002 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36946,019,603 - 46,022,914 (+)NCBIMGSCv36mm8
Celera943,557,616 - 43,560,927 (+)NCBICelera
Cytogenetic Map9A5.2NCBI
Apoa5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541218,129,603 - 18,131,115 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541218,128,861 - 18,131,752 (-)NCBIChiLan1.0ChiLan1.0
APOA5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111115,559,231 - 115,562,286 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11115,559,231 - 115,562,286 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011111,625,403 - 111,627,932 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
APOA5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1516,774,117 - 16,777,535 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl516,774,501 - 16,777,768 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha516,826,641 - 16,829,696 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0516,721,181 - 16,724,236 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl516,721,199 - 16,723,685 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1516,858,043 - 16,861,098 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0516,760,620 - 16,763,675 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0516,803,753 - 16,806,810 (+)NCBIUU_Cfam_GSD_1.0
Apoa5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494799,147,591 - 99,149,935 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365422,069,683 - 2,071,353 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049365422,069,683 - 2,071,344 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOA5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl944,178,606 - 44,180,885 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1944,177,834 - 44,180,880 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2949,251,674 - 49,254,883 (-)NCBISscrofa10.2Sscrofa10.2susScr3
APOA5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11108,154,880 - 108,158,998 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1108,155,641 - 108,157,375 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604317,891,675 - 17,894,161 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Apoa5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478412,213,744 - 12,216,026 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462478412,213,205 - 12,216,039 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Apoa5
13 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:226
Count of miRNA genes:164
Interacting mature miRNAs:176
Transcripts:ENSRNOT00000024918
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)81933115293965294Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82266233067662330Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82613018771130187Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)82613018771130187Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82664491246711092Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82720571554998217Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)82720571599103503Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)82720571599103503Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)82720571599103503Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)82824291253961020Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)82824291273242912Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)82824291299525068Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)82950266550095447Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)82950266570386295Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)83018886794457446Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815458482492Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83084815461290444Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83084815461290444Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83084815461290444Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83084815482460899Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83084815482460899Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83084815482460899Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83084815482460899Rat
1578755Pur5Proteinuria QTL 53.30.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)830848154101699754Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)830848154101699754Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)830848154101699754Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)830848259105647037Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83085640475856404Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83173772976737729Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83555193880551938Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83558203280582032Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83646953599083736Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84071306682925667Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)84071306693965294Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84186687675097878Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84186687686866876Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84186701070386132Rat
5684993Bmd84Bone mineral density QTL 844.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)84269268450095447Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84269268490165460Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)84329616998968765Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)84329616998968765Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)84329616998968765Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)84329616998968765Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)84329616998968765Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)84329616998968765Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)846531639119088624Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088624Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)84653172299083736Rat

Markers in Region
D8Got344  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,564,061 - 46,564,213 (+)MAPPERmRatBN7.2
Rnor_6.0850,561,961 - 50,562,114NCBIRnor6.0
Rnor_5.0849,187,923 - 49,188,076UniSTSRnor5.0
RGSC_v3.4849,256,021 - 49,256,174UniSTSRGSC3.4
Celera846,145,828 - 46,145,981UniSTS
Cytogenetic Map8q23UniSTS
RH139127  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,563,175 - 46,563,302 (+)MAPPERmRatBN7.2
Rnor_6.0850,561,075 - 50,561,201NCBIRnor6.0
Rnor_5.0849,187,037 - 49,187,163UniSTSRnor5.0
RGSC_v3.4849,255,135 - 49,255,261UniSTSRGSC3.4
Celera846,144,942 - 46,145,068UniSTS
RH 3.4 Map8478.2UniSTS
Cytogenetic Map8q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 2 2 2
Medium 21 21 21 1
Low 1 2 22 14 5 14 3 3 23 2 17 7 3
Below cutoff 1 20 12 4 14 4 4 5 31 23 23 4 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024918   ⟹   ENSRNOP00000024918
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl846,561,229 - 46,563,816 (+)Ensembl
Rnor_6.0 Ensembl850,559,126 - 50,561,736 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000102490   ⟹   ENSRNOP00000094966
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl846,561,229 - 46,563,816 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115729   ⟹   ENSRNOP00000081357
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl846,561,334 - 46,562,629 (+)Ensembl
RefSeq Acc Id: NM_001277264   ⟹   NP_001264193
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2846,561,180 - 46,563,818 (+)NCBI
Rnor_6.0850,559,079 - 50,561,717 (+)NCBI
Rnor_5.0849,185,041 - 49,187,682 (+)NCBI
Celera846,142,946 - 46,145,584 (+)NCBI
Sequence:
RefSeq Acc Id: NM_080576   ⟹   NP_542143
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2846,561,334 - 46,563,818 (+)NCBI
Rnor_6.0850,559,233 - 50,561,717 (+)NCBI
Rnor_5.0849,185,041 - 49,187,682 (+)NCBI
RGSC_v3.4849,253,538 - 49,255,777 (+)RGD
Celera846,143,100 - 46,145,584 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_542143   ⟸   NM_080576
- Peptide Label: precursor
- UniProtKB: Q5FVT8 (UniProtKB/Swiss-Prot),   Q9QUH3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001264193   ⟸   NM_001277264
- Peptide Label: precursor
- UniProtKB: Q5FVT8 (UniProtKB/Swiss-Prot),   Q9QUH3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024918   ⟸   ENSRNOT00000024918
RefSeq Acc Id: ENSRNOP00000081357   ⟸   ENSRNOT00000115729
RefSeq Acc Id: ENSRNOP00000094966   ⟸   ENSRNOT00000102490

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9QUH3-F1-model_v2 AlphaFold Q9QUH3 1-367 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695930
Promoter ID:EPDNEW_R6455
Type:initiation region
Name:Apoa5_1
Description:apolipoprotein A5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0850,559,079 - 50,559,139EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70903 AgrOrtholog
BioCyc Gene G2FUF-30649 BioCyc
Ensembl Genes ENSRNOG00000018436 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000024918 ENTREZGENE
  ENSRNOP00000024918.4 UniProtKB/TrEMBL
  ENSRNOP00000081357.1 UniProtKB/TrEMBL
  ENSRNOP00000094966.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000024918 ENTREZGENE
  ENSRNOT00000024918.6 UniProtKB/TrEMBL
  ENSRNOT00000102490.1 UniProtKB/TrEMBL
  ENSRNOT00000115729.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7371817 IMAGE-MGC_LOAD
InterPro ApoA_E UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:140638 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108612 IMAGE-MGC_LOAD
NCBI Gene 140638 ENTREZGENE
Pfam Apolipoprotein UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB APOA5 RGD
PhenoGen Apoa5 PhenoGen
UniProt A0A0H2UHP7_RAT UniProtKB/TrEMBL
  A0A8I5ZSC8_RAT UniProtKB/TrEMBL
  A0A8I6ASM1_RAT UniProtKB/TrEMBL
  APOA5_RAT UniProtKB/Swiss-Prot
  Q5FVT8 ENTREZGENE
  Q9QUH3 ENTREZGENE
UniProt Secondary Q5FVT8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Apoa5  apolipoprotein A5  Apoa5  apolipoprotein A-V  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Apoa5  apolipoprotein A-V      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 70662
gene_regulation highly expressed after 70% hepatectomy (PHx) 70662