Slc7a1 (solute carrier family 7 member 1) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Slc7a1 (solute carrier family 7 member 1) Rattus norvegicus
Analyze
Symbol: Slc7a1
Name: solute carrier family 7 member 1
RGD ID: 3716
Description: Enables L-arginine transmembrane transporter activity. Involved in L-arginine import across plasma membrane; L-arginine transmembrane transport; and regulation of TOR signaling. Located in apical plasma membrane and basal plasma membrane. Orthologous to human SLC7A1 (solute carrier family 7 member 1); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Atrc1; Cat-1; CAT1; cationic amino acid transporter, y+ system; cationinc amino acid transporter 1; EcoR; ecotropic retroviral leukemia receptor; ecotropic retrovirus receptor; ERR; high affinity cationic amino acid transporter 1; solute carrier family 7 (cationic amino acid transporter, y+ system), member 1; Solute carrier family 7 member A1 (amino acid transporter cationic 1); solute carrier family 7, member 1; system Y+ basic amino acid transporter
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,664,488 - 11,740,030 (+)NCBIGRCr8
mRatBN7.2126,628,288 - 6,703,849 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl126,628,007 - 6,703,849 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx127,313,543 - 7,387,012 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,936,680 - 8,010,153 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,964,688 - 7,038,155 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0128,032,775 - 8,108,972 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl128,032,809 - 8,108,972 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01210,119,575 - 10,192,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,230,519 - 7,253,858 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1127,260,446 - 7,283,785 (+)NCBI
Celera128,375,860 - 8,449,856 (+)NCBICelera
RH 3.4 Map1274.6RGD
Cytogenetic Map12p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-alpha-phellandrene  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-bromohexadecanoic acid  (ISO)
2-butoxyethanol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-iodothyronamine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetamide  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alachlor  (EXP)
all-trans-retinoic acid  (ISO)
alpha-phellandrene  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (ISO)
bromobenzene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroacetaldehyde  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (EXP,ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (EXP)
diclofenac  (ISO)
dicrotophos  (ISO)
dioxygen  (EXP,ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
fenofibrate  (EXP,ISO)
fenvalerate  (EXP)
fluoranthene  (ISO)
folic acid  (ISO)
ibuprofen  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
manganese(II) chloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP,ISO)
methimazole  (EXP)
methylmercury chloride  (ISO)
motexafin gadolinium  (ISO)
N(4)-hydroxycytidine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel sulfate  (ISO)
oxaliplatin  (EXP)
ozone  (EXP)
paracetamol  (EXP)
paraquat  (EXP,ISO)
PCB138  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylephrine  (EXP)
phorone  (EXP)
pirinixic acid  (EXP)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
Soman  (EXP)
sulfadimethoxine  (EXP)
sulindac  (ISO)
sunitinib  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
toluene  (EXP)
topiramate  (EXP)
topotecan  (EXP)
triazines  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (ISO)
trovafloxacin  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc acetate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular sites of regulation of expression of the rat cationic amino acid transporter gene. Aulak KS, etal., J Biol Chem 1996 Nov 22;271(47):29799-806.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. Huang Y, etal., J Neurosci. 2007 Jan 17;27(3):449-58.
5. A glycosylation-defective variant of the ecotropic murine retrovirus receptor is expressed in rat XC cells. Kubo Y, etal., Virology 2002 Nov 25;303(2):338-44.
6. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Developmental changes of l-arginine transport at the blood-brain barrier in rats. Tachikawa M, etal., Microvasc Res. 2018 May;117:16-21. doi: 10.1016/j.mvr.2017.12.003. Epub 2017 Dec 14.
13. Contribution of virus-receptor interaction to distinct viral proliferation of neuropathogenic and nonneuropathogenic murine leukemia viruses in rat glial cells. Takase-Yoden S and Watanabe R, J Virol 1999 May;73(5):4461-4.
14. Cationic amino acid transporter 1-mediated L-arginine transport at the inner blood-retinal barrier. Tomi M, etal., J Neurochem. 2009 Nov;111(3):716-25. doi: 10.1111/j.1471-4159.2009.06367.x. Epub 2009 Aug 27.
Additional References at PubMed
PMID:8195186   PMID:8385111   PMID:8473910   PMID:11114306   PMID:11877448   PMID:12757712   PMID:14523001   PMID:15849232   PMID:17042743   PMID:17178122   PMID:17197568   PMID:18552509  
PMID:19386725   PMID:19420114   PMID:19720825   PMID:19843630   PMID:19946888   PMID:25747984   PMID:28089735   PMID:28246125  


Genomics

Comparative Map Data
Slc7a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81211,664,488 - 11,740,030 (+)NCBIGRCr8
mRatBN7.2126,628,288 - 6,703,849 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl126,628,007 - 6,703,849 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx127,313,543 - 7,387,012 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0127,936,680 - 8,010,153 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0126,964,688 - 7,038,155 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0128,032,775 - 8,108,972 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl128,032,809 - 8,108,972 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01210,119,575 - 10,192,908 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4127,230,519 - 7,253,858 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1127,260,446 - 7,283,785 (+)NCBI
Celera128,375,860 - 8,449,856 (+)NCBICelera
RH 3.4 Map1274.6RGD
Cytogenetic Map12p11NCBI
SLC7A1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381329,509,414 - 29,595,688 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1329,509,414 - 29,595,688 (-)EnsemblGRCh38hg38GRCh38
GRCh371330,083,551 - 30,169,825 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361328,981,551 - 29,067,721 (-)NCBINCBI36Build 36hg18NCBI36
Build 341328,981,551 - 29,067,721NCBI
Celera1311,159,177 - 11,245,451 (-)NCBICelera
Cytogenetic Map13q12.3NCBI
HuRef1310,903,933 - 10,990,064 (-)NCBIHuRef
CHM1_11330,051,292 - 30,137,305 (-)NCBICHM1_1
T2T-CHM13v2.01328,732,320 - 28,818,340 (-)NCBIT2T-CHM13v2.0
Slc7a1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395148,264,220 - 148,336,714 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5148,264,220 - 148,336,714 (-)EnsemblGRCm39 Ensembl
GRCm385148,327,410 - 148,399,904 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5148,327,410 - 148,399,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv375149,138,986 - 149,211,480 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv365148,638,675 - 148,710,228 (-)NCBIMGSCv36mm8
Celera5146,326,464 - 146,400,567 (-)NCBICelera
Cytogenetic Map5G3NCBI
cM Map588.48NCBI
Slc7a1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543116,260,605 - 16,315,332 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543116,270,648 - 16,315,280 (+)NCBIChiLan1.0ChiLan1.0
SLC7A1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21429,098,114 - 29,183,614 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11320,205,111 - 20,290,480 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01310,791,600 - 10,877,082 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11328,832,128 - 28,907,403 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1328,837,200 - 28,907,403 (-)Ensemblpanpan1.1panPan2
SLC7A1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12510,272,949 - 10,363,793 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2510,292,926 - 10,359,383 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2510,337,889 - 10,404,361 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02510,337,606 - 10,477,631 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2510,406,689 - 10,476,852 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12510,300,565 - 10,367,010 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02510,308,115 - 10,374,587 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02510,349,966 - 10,416,429 (+)NCBIUU_Cfam_GSD_1.0
Slc7a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945171,434,308 - 171,509,248 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647224,444,772 - 24,517,792 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493647224,442,907 - 24,517,834 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC7A1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl116,538,045 - 6,604,658 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1116,538,053 - 6,604,654 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2116,317,578 - 6,359,913 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap11pNCBI
SLC7A1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.138,522,268 - 8,606,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl38,527,273 - 8,606,402 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605735,759,948 - 35,844,081 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc7a1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247768,897,489 - 8,934,722 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247768,859,519 - 8,935,370 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc7a1
623 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:663
Count of miRNA genes:293
Interacting mature miRNAs:387
Transcripts:ENSRNOT00000001234
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2312418Kidm41Kidney mass QTL 413.70.0001kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)12119611090Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
9590147Scort7Serum corticosterone level QTL 713.610.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)12142110980Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449846669029Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)12610757946669029Rat
1581516Cm56Cardiac mass QTL 564.20.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)12129333307Rat
9590086Insglur6Insulin/glucose ratio QTL 618.970.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)12142110980Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)12556449546669029Rat
6893681Bw109Body weight QTL 1092.30.004body mass (VT:0001259)body weight (CMO:0000012)12123297788Rat
1300174Bw15Body weight QTL 152.93body mass (VT:0001259)body weight loss (CMO:0001399)1219318387Rat
1598855Bp294Blood pressure QTL 2943.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12134851688Rat
10755457Coatc14Coat color QTL 140.01759coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)12122591684Rat
724526Uae3Urinary albumin excretion QTL 34.90.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)12390696910373166Rat
634351Apr5Acute phase response QTL 56.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)12144503507Rat
8694179Bw150Body weight QTL 1502.90.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
634350Apr4Acute phase response QTL 46orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)12117200546172005Rat
7411545Bw128Body weight QTL 1285.20.001body mass (VT:0001259)body weight gain (CMO:0000420)12142110980Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)6556449546669029Rat
737979Pia22Pristane induced arthritis QTL 2253.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12144465750Rat
7411586Foco5Food consumption QTL 55.40.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12142450532Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)127977298525593Rat
2302042Pia38Pristane induced arthritis QTL 383.50.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)12144503507Rat
7411595Foco9Food consumption QTL 940.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12556449546669029Rat
7411660Foco28Food consumption QTL 2810.90.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)12142110980Rat

Markers in Region
D12Wox21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,701,277 - 6,701,595 (+)MAPPERmRatBN7.2
Rnor_6.0128,106,403 - 8,106,718NCBIRnor6.0
Rnor_5.01210,190,339 - 10,190,654UniSTSRnor5.0
RGSC_v3.4127,251,289 - 7,251,604UniSTSRGSC3.4
Celera128,447,287 - 8,447,602UniSTS
Cytogenetic Map12p11UniSTS
D12Got206  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,684,210 - 6,684,370 (+)MAPPERmRatBN7.2
Rnor_6.0128,089,341 - 8,089,500NCBIRnor6.0
Rnor_5.01210,173,277 - 10,173,436UniSTSRnor5.0
RGSC_v3.4127,234,218 - 7,234,377UniSTSRGSC3.4
Celera128,430,260 - 8,430,401UniSTS
Cytogenetic Map12p11UniSTS
RH94683  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,701,536 - 6,701,725 (+)MAPPERmRatBN7.2
Rnor_6.0128,106,660 - 8,106,848NCBIRnor6.0
Rnor_5.01210,190,596 - 10,190,784UniSTSRnor5.0
RGSC_v3.4127,251,546 - 7,251,734UniSTSRGSC3.4
Celera128,447,544 - 8,447,732UniSTS
RH 3.4 Map1274.6UniSTS
Cytogenetic Map12p11UniSTS
RH143690  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,702,776 - 6,702,885 (+)MAPPERmRatBN7.2
Rnor_6.0128,107,900 - 8,108,008NCBIRnor6.0
Rnor_5.01210,191,836 - 10,191,944UniSTSRnor5.0
RGSC_v3.4127,252,786 - 7,252,894UniSTSRGSC3.4
Celera128,448,784 - 8,448,892UniSTS
RH 3.4 Map1272.1UniSTS
Cytogenetic Map12p11UniSTS
BE113036  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,703,624 - 6,703,792 (+)MAPPERmRatBN7.2
Rnor_6.0128,108,748 - 8,108,915NCBIRnor6.0
Rnor_5.01210,192,684 - 10,192,851UniSTSRnor5.0
RGSC_v3.4127,253,634 - 7,253,801UniSTSRGSC3.4
Celera128,449,632 - 8,449,799UniSTS
RH 3.4 Map1274.7UniSTS
Cytogenetic Map12p11UniSTS
BI276254  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2126,700,041 - 6,700,215 (+)MAPPERmRatBN7.2
Rnor_6.0128,105,167 - 8,105,340NCBIRnor6.0
Rnor_5.01210,189,103 - 10,189,276UniSTSRnor5.0
RGSC_v3.4127,250,053 - 7,250,226UniSTSRGSC3.4
Celera128,446,051 - 8,446,224UniSTS
RH 3.4 Map1270.3UniSTS
Cytogenetic Map12p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 22 26 16 6 16 73 16 20
Low 2 21 20 14 13 14 6 7 1 19 21 11 6
Below cutoff 11 11 11 2 4 2

Sequence


Ensembl Acc Id: ENSRNOT00000001234   ⟹   ENSRNOP00000001234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl128,085,525 - 8,108,972 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000082850   ⟹   ENSRNOP00000072647
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl126,628,007 - 6,703,849 (+)Ensembl
Rnor_6.0 Ensembl128,032,809 - 8,106,507 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000089804   ⟹   ENSRNOP00000075532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl128,085,525 - 8,108,532 (+)Ensembl
RefSeq Acc Id: NM_001399982   ⟹   NP_001386911
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,664,488 - 11,740,030 (+)NCBI
mRatBN7.2126,628,288 - 6,703,849 (+)NCBI
RefSeq Acc Id: XM_063271087   ⟹   XP_063127157
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81211,679,641 - 11,740,030 (+)NCBI
Ensembl Acc Id: ENSRNOP00000072647   ⟸   ENSRNOT00000082850
Ensembl Acc Id: ENSRNOP00000075532   ⟸   ENSRNOT00000089804
Ensembl Acc Id: ENSRNOP00000001234   ⟸   ENSRNOT00000001234
RefSeq Acc Id: NP_001386911   ⟸   NM_001399982
- UniProtKB: P70608 (UniProtKB/TrEMBL),   Q8VIA9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063127157   ⟸   XM_063271087
- Peptide Label: isoform X1
- UniProtKB: Q8VIA9 (UniProtKB/TrEMBL),   P70608 (UniProtKB/TrEMBL)
Protein Domains
Cationic amino acid transporter C-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30823-F1-model_v2 AlphaFold P30823 1-624 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698399
Promoter ID:EPDNEW_R8921
Type:initiation region
Name:Slc7a1_1
Description:solute carrier family 7 member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0128,032,851 - 8,032,911EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3716 AgrOrtholog
BioCyc Gene G2FUF-20134 BioCyc
Ensembl Genes ENSRNOG00000000924 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082850.2 UniProtKB/TrEMBL
Gene3D-CATH Amino acid/polyamine transporter I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro AA/rel_permease1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cat_AA_permease UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAT_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25648 UniProtKB/TrEMBL
NCBI Gene 25648 ENTREZGENE
PANTHER HIGH AFFINITY CATIONIC AMINO ACID TRANSPORTER 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INNER MEMBRANE TRANSPORTER YGJI-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam AA_permease_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AA_permease_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc7a1 PhenoGen
PIRSF AA_transporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000924 RatGTEx
UniProt A0A0G2K3I1_RAT UniProtKB/TrEMBL
  CTR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P70608 ENTREZGENE, UniProtKB/TrEMBL
  Q3V5G8_RAT UniProtKB/TrEMBL
  Q8VIA9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc7a1  solute carrier family 7 member 1  Slc7a1  solute carrier family 7 (cationic amino acid transporter, y+ system), member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc7a1  solute carrier family 7 (cationic amino acid transporter, y+ system), member 1    solute carrier family 7, member 1  Name updated 1299863 APPROVED
2003-04-09 Slc7a1  solute carrier family 7, member 1    Solute carrier family 7 member A1 (amino acid transporter cationic 1)  Name updated 629478 APPROVED
2002-06-10 Slc7a1  Solute carrier family 7 member A1 (amino acid transporter cationic 1)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in regenerating liver 730128
gene_function receptor for ecotropic murine leukemia viruses; binds to Env protein 730156
gene_process required for transport of cationic amino acids and polyamines in liver cells during late G1 phase; function as a delayed early growth response gene in regenerating liver 730128
gene_protein protein is N-glycosylated 730156
gene_transcript alternatively polyadenylated to produce 7.9 kb and 3.4 kb transcripts 730128