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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3716
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc7a1
Name: solute carrier family 7 member 1
Acc ID: CHEBI:2504
Term: aflatoxin B1
Definition: An aflatoxin having a tetrahydrocyclopenta[c]furo[3',2':4,5]furo[2,3-h]chromene skeleton with oxygen functionality at positions 1, 4 and 11.
Chemical ID: MESH:D016604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDAflatoxin B1 results in increased expression of SLC7A1 mRNA

PMID:25378103
decreases expressionISORGD:113166480464CTDAflatoxin B1 results in decreased expression of SLC7A1 mRNA

PMID:19770486
increases expressionISORGD:7363496480464CTDAflatoxin B1 results in increased expression of SLC7A1 mRNA

PMID:22100608
increases methylationISORGD:7363496480464CTDAflatoxin B1 results in increased methylation of SLC7A1 intron

PMID:30157460
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.