Lpar3 (lysophosphatidic acid receptor 3) - Rat Genome Database

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Gene: Lpar3 (lysophosphatidic acid receptor 3) Rattus norvegicus
Analyze
Symbol: Lpar3
Name: lysophosphatidic acid receptor 3
RGD ID: 620565
Description: Enables G-protein alpha-subunit binding activity and phospholipid binding activity. Involved in G protein-coupled receptor signaling pathway and positive regulation of calcium ion transport. Predicted to be located in axon. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human LPAR3 (lysophosphatidic acid receptor 3); PARTICIPATES IN G protein mediated signaling pathway via Galphaq family; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Edg7; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7; LPA receptor 3; LPA-3; lysophosphatidic acid receptor Edg-7; putative G protein-coupled receptor snGPCR32; snGPCR32
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22235,125,234 - 235,193,916 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2235,149,065 - 235,193,357 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2242,938,279 - 242,984,731 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02240,829,716 - 240,876,162 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02235,695,897 - 235,742,354 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02252,090,634 - 252,159,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,090,669 - 252,159,903 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02270,610,856 - 270,679,592 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,431,789 - 244,510,815 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12244,418,528 - 244,497,555 (+)NCBI
Celera2227,128,872 - 227,173,700 (+)NCBICelera
Cytogenetic Map2q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (EXP)
1-octadec-9-enoylglycero-3-phosphate  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-nonylphenol  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
bucladesine  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlordecone  (ISO)
chromium(6+)  (ISO)
cyhalothrin  (EXP)
cypermethrin  (EXP)
decabromodiphenyl ether  (EXP)
dextran sulfate  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
fenvalerate  (EXP)
flusilazole  (EXP)
furan  (EXP)
glyphosate  (EXP,ISO)
GW 4064  (ISO)
lipopolysaccharide  (ISO)
medroxyprogesterone acetate  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
mifepristone  (ISO)
N-ethyl-N-nitrosourea  (ISO)
nickel sulfate  (ISO)
Nor-9-carboxy-delta9-THC  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylmercury acetate  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
pyrethrins  (EXP)
quercitrin  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
axon  (IEA,ISO)
cytoplasm  (IBA)
plasma membrane  (IBA,IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Lysophosphatidic acid (LPA) receptors are activated differentially by biological fluids: possible role of LPA-binding proteins in activation of LPA receptors. Hama K, etal., FEBS Lett 2002 Jul 17;523(1-3):187-92.
4. Vascular smooth muscle migration and proliferation in response to lysophosphatidic acid (LPA) is mediated by LPA receptors coupling to Gq. Kim J, etal., Cell Signal. 2006 Oct;18(10):1695-701. Epub 2006 Feb 28.
5. Lysophosphatidic acid stimulates cell proliferation in rat chondrocytes. Kim MK, etal., Biochem Pharmacol. 2005 Dec 5;70(12):1764-71. Epub 2005 Oct 20.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells. Moller T, etal., J Biol Chem. 2001 Jul 13;276(28):25946-52. Epub 2001 May 4.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Thrombogenic and atherogenic activities of lysophosphatidic acid. Siess W and Tigyi G, J Cell Biochem. 2004 Aug 15;92(6):1086-94.
Additional References at PubMed
PMID:15755723   PMID:17135244   PMID:19757175   PMID:21255556   PMID:22161812   PMID:22465231   PMID:23711961   PMID:23790320   PMID:23867992   PMID:26473723   PMID:28922661  


Genomics

Comparative Map Data
Lpar3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22235,125,234 - 235,193,916 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2235,149,065 - 235,193,357 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2242,938,279 - 242,984,731 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02240,829,716 - 240,876,162 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02235,695,897 - 235,742,354 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02252,090,634 - 252,159,221 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2252,090,669 - 252,159,903 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02270,610,856 - 270,679,592 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42244,431,789 - 244,510,815 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12244,418,528 - 244,497,555 (+)NCBI
Celera2227,128,872 - 227,173,700 (+)NCBICelera
Cytogenetic Map2q44NCBI
LPAR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38184,811,602 - 84,893,206 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl184,811,602 - 84,893,206 (-)EnsemblGRCh38hg38GRCh38
GRCh37185,277,285 - 85,358,889 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36185,052,090 - 85,104,430 (-)NCBINCBI36Build 36hg18NCBI36
Build 34184,991,521 - 85,043,863NCBI
Celera183,522,972 - 83,602,786 (-)NCBICelera
Cytogenetic Map1p22.3NCBI
HuRef183,389,042 - 83,468,839 (-)NCBIHuRef
CHM1_1185,393,947 - 85,473,763 (-)NCBICHM1_1
T2T-CHM13v2.0184,652,193 - 84,733,814 (-)NCBIT2T-CHM13v2.0
Lpar3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393145,926,716 - 145,991,969 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3145,926,718 - 145,991,941 (+)EnsemblGRCm39 Ensembl
GRCm383146,220,961 - 146,286,214 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3146,220,963 - 146,286,186 (+)EnsemblGRCm38mm10GRCm38
MGSCv373145,883,925 - 145,949,178 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363146,158,371 - 146,223,572 (+)NCBIMGSCv36mm8
Celera3152,671,994 - 152,737,437 (+)NCBICelera
Cytogenetic Map3H2NCBI
cM Map371.03NCBI
Lpar3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554239,063,804 - 9,133,230 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554239,063,804 - 9,133,203 (+)NCBIChiLan1.0ChiLan1.0
LPAR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11141,204,090 - 141,285,732 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,359,661 - 117,441,297 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1186,219,789 - 86,274,228 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl186,222,008 - 86,274,228 (-)Ensemblpanpan1.1panPan2
LPAR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1663,035,332 - 63,114,697 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl663,035,746 - 63,113,251 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha665,683,188 - 65,761,599 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0663,572,971 - 63,651,406 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl663,596,424 - 63,651,257 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1663,102,662 - 63,181,018 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0663,070,490 - 63,149,065 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0663,578,995 - 63,657,390 (+)NCBIUU_Cfam_GSD_1.0
Lpar3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505895,460,869 - 95,534,416 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936608771,559 - 845,176 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936608771,618 - 845,176 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LPAR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6128,860,210 - 128,937,763 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16128,860,210 - 128,937,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26119,296,648 - 119,374,246 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q2.6-3.2NCBI
LPAR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12048,457,903 - 48,538,754 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2048,485,708 - 48,540,513 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603369,229,208 - 69,311,934 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lpar3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474212,616,910 - 12,691,496 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474212,616,954 - 12,691,226 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lpar3
443 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:97
Interacting mature miRNAs:112
Transcripts:ENSRNOT00000020656
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2229059610249053267Rat

Markers in Region
D2Got405  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,168,279 - 235,168,417 (+)MAPPERmRatBN7.2
Rnor_6.02252,133,587 - 252,133,724NCBIRnor6.0
Rnor_5.02270,653,958 - 270,654,095UniSTSRnor5.0
RGSC_v3.42244,485,328 - 244,485,465UniSTSRGSC3.4
Celera2227,148,088 - 227,148,225UniSTS
Cytogenetic Map2q44UniSTS
RH131545  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,193,090 - 235,193,304 (+)MAPPERmRatBN7.2
Rnor_6.02252,158,398 - 252,158,611NCBIRnor6.0
Rnor_5.02270,678,769 - 270,678,982UniSTSRnor5.0
RGSC_v3.42244,510,139 - 244,510,352UniSTSRGSC3.4
RGSC_v3.42244,510,139 - 244,511,408UniSTSRGSC3.4
Celera2227,173,024 - 227,173,237UniSTS
Cytogenetic Map2q44UniSTS
PMC133668P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22235,149,301 - 235,149,703 (+)MAPPERmRatBN7.2
Rnor_6.02252,114,608 - 252,115,009NCBIRnor6.0
Rnor_5.02270,635,008 - 270,635,409UniSTSRnor5.0
RGSC_v3.42244,432,024 - 244,432,425UniSTSRGSC3.4
Celera2227,129,107 - 227,129,508UniSTS
Cytogenetic Map2q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 7 10 7
Low 3 42 25 15 18 15 8 11 16 28 25 4 8
Below cutoff 1 28 22 1 22 58 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000020656   ⟹   ENSRNOP00000020656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2252,090,669 - 252,159,903 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000112864   ⟹   ENSRNOP00000089155
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2235,149,065 - 235,193,357 (+)Ensembl
RefSeq Acc Id: NM_023969   ⟹   NP_076459
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,149,067 - 235,193,767 (+)NCBI
Rnor_6.02252,114,373 - 252,159,072 (+)NCBI
Rnor_5.02270,610,856 - 270,679,592 (+)NCBI
RGSC_v3.42244,431,789 - 244,510,815 (+)RGD
Celera2227,128,872 - 227,173,700 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233469   ⟹   XP_006233531
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,127,396 - 235,193,916 (+)NCBI
Rnor_6.02252,092,690 - 252,159,221 (+)NCBI
Rnor_5.02270,610,856 - 270,679,592 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006233470   ⟹   XP_006233532
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,125,234 - 235,193,916 (+)NCBI
Rnor_6.02252,090,634 - 252,159,221 (+)NCBI
Rnor_5.02270,610,856 - 270,679,592 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039103115   ⟹   XP_038959043
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22235,139,915 - 235,193,916 (+)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_076459   ⟸   NM_023969
- UniProtKB: A0A8I6A9K7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233532   ⟸   XM_006233470
- Peptide Label: isoform X1
- UniProtKB: Q9ESJ6 (UniProtKB/Swiss-Prot),   Q8K5E0 (UniProtKB/Swiss-Prot),   A6HWD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233531   ⟸   XM_006233469
- Peptide Label: isoform X1
- UniProtKB: Q9ESJ6 (UniProtKB/Swiss-Prot),   Q8K5E0 (UniProtKB/Swiss-Prot),   A6HWD3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000020656   ⟸   ENSRNOT00000020656
RefSeq Acc Id: XP_038959043   ⟸   XM_039103115
- Peptide Label: isoform X1
- UniProtKB: Q8K5E0 (UniProtKB/Swiss-Prot),   Q9ESJ6 (UniProtKB/Swiss-Prot),   A6HWD3 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089155   ⟸   ENSRNOT00000112864
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8K5E0-F1-model_v2 AlphaFold Q8K5E0 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620565 AgrOrtholog
BioCyc Gene G2FUF-50905 BioCyc
Ensembl Genes ENSRNOG00000015260 Ensembl
  ENSRNOG00000064204 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000089155 ENTREZGENE
  ENSRNOP00000089155.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000112864 ENTREZGENE
  ENSRNOT00000112864.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPA_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPA_rcpt_EDG7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:66025 UniProtKB/Swiss-Prot
NCBI Gene 66025 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LYSOPHOSPHATIDIC ACID RECEPTOR 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lpar3 PhenoGen
PRINTS EDG7RECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LPARECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6A9K7 ENTREZGENE, UniProtKB/TrEMBL
  A6HWD3 ENTREZGENE, UniProtKB/TrEMBL
  LPAR3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q9ESJ6 ENTREZGENE
UniProt Secondary Q9ESJ6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-04-17 Lpar3  lysophosphatidic acid receptor 3  Edg7  endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7  Data Merged 737654 PROVISIONAL
2008-04-30 Edg7  endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7   Edg7_predicted  endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7 (predicted)  'predicted' is removed 2292626 APPROVED
2008-04-25 Lpar3  lysophosphatidic acid receptor 3  Edg7  endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 Edg7  endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7  Edg7  putative G protein-coupled receptor snGPCR32  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-12 Edg7_predicted  endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 7 (predicted)      Symbol and Name status set to approved 70820 APPROVED
2002-08-07 Edg7  putative G protein-coupled receptor snGPCR32      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_regulation inhibited by serum albumin, but activated in seminal plasma 727394