Sirt3 (sirtuin 3) - Rat Genome Database

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Gene: Sirt3 (sirtuin 3) Rattus norvegicus
Analyze
Symbol: Sirt3
Name: sirtuin 3
RGD ID: 1308374
Description: Enables enzyme binding activity. Involved in negative regulation of ERK1 and ERK2 cascade; negative regulation of reactive oxygen species metabolic process; and positive regulation of insulin secretion. Predicted to be located in mitochondrial inner membrane and mitochondrial matrix. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Used to study metabolic dysfunction-associated steatotic liver disease. Biomarker of congestive heart failure; myocardial infarction; obesity; and prediabetes syndrome. Orthologous to human SIRT3 (sirtuin 3); PARTICIPATES IN histone modification pathway; Sirtuin mediated pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1,3,7,9-tetramethyluric acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC293615; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; SIRT3L mitochondrial; sirtuin; sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae); sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Sirt3em25Mcwi   Sirt3em4Mcwi   Sirt3em35Mcwi   Sirt3em30Mcwi  
Genetic Models: SS-Sirt3em25Mcwi T2DN-Sirt3em30Mcwi T2DN-Sirt3em35Mcwi SS-Sirt3em4Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,371,703 - 205,394,145 (-)NCBIGRCr8
mRatBN7.21195,942,066 - 195,964,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,942,073 - 195,964,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,294,536 - 204,318,293 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,421,447 - 211,445,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,095,300 - 204,119,047 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,613,502 - 213,636,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,613,513 - 213,635,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,539,132 - 220,561,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,021,391 - 201,043,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,172,601 - 201,193,816 (-)NCBI
Celera1193,586,014 - 193,607,810 (-)NCBICelera
Cytogenetic Map1q41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP,ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3,7,9-tetramethyluric acid  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
4-hydroxynon-2-enal  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
ADP  (ISO)
aldehydo-D-glucose  (ISO)
alpha-mangostin  (ISO)
amitrole  (EXP)
antimycin A  (ISO)
arsenous acid  (EXP)
ATP  (ISO)
atrazine  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bisphenol A  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
CGS-21680  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (ISO)
curcumin  (EXP,ISO)
D-glucose  (ISO)
deguelin  (ISO)
diarsenic trioxide  (EXP)
diazinon  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (ISO)
diisononyl phthalate  (ISO)
doxorubicin  (EXP,ISO)
estriol  (ISO)
ethanol  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
gentamycin  (EXP)
glucose  (ISO)
hesperetin  (ISO)
hexadecanoic acid  (ISO)
Honokiol  (EXP)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (EXP,ISO)
hydroquinone  (ISO)
icariin  (EXP)
L-methionine  (ISO)
lead diacetate  (ISO)
linalool  (ISO)
lipoic acid  (EXP,ISO)
lipopolysaccharide  (EXP)
mancozeb  (ISO)
maneb  (ISO)
metformin  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
metiram  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-methyl-4-phenylpyridinium  (EXP)
nebivolol  (ISO)
nicotinamide  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
propionic acid  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sodium sulfide (anhydrous)  (EXP)
Soman  (EXP)
stavudine  (ISO)
sulfadimethoxine  (EXP)
tenofovir disoproxil fumarate  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP)
trilobatin  (EXP)
triptonide  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vancomycin  (ISO)
zidovudine  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning. Borengasser SJ, etal., PLoS One. 2011;6(8):e24068. doi: 10.1371/journal.pone.0024068. Epub 2011 Aug 25.
2. Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients. Caton PW, etal., Diabetologia. 2013 May;56(5):1068-77. doi: 10.1007/s00125-013-2851-y. Epub 2013 Feb 9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Non-histone lysine acetylated proteins in heart failure. Grillon JM, etal., Biochim Biophys Acta. 2012 Apr;1822(4):607-14. doi: 10.1016/j.bbadis.2011.11.016. Epub 2011 Dec 3.
5. In mammalian muscle, SIRT3 is present in mitochondria and not in the nucleus; and SIRT3 is upregulated by chronic muscle contraction in an adenosine monophosphate-activated protein kinase-independent manner. Gurd BJ, etal., Metabolism. 2012 May;61(5):733-41. doi: 10.1016/j.metabol.2011.09.016. Epub 2011 Nov 9.
6. Aerobic interval training protects against myocardial infarction-induced oxidative injury by enhancing antioxidase system and mitochondrial biosynthesis. Jiang HK, etal., Clin Exp Pharmacol Physiol. 2014 Mar;41(3):192-201. doi: 10.1111/1440-1681.12211.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Physical and functional HAT/HDAC interplay regulates protein acetylation balance. Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
9. Pre-diabetes alters testicular PGC1-alpha/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress. Rato L, etal., Biochim Biophys Acta. 2014 Mar;1837(3):335-44. doi: 10.1016/j.bbabio.2013.12.008. Epub 2013 Dec 20.
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3. Valdecantos MP, etal., Obesity (Silver Spring). 2012 Oct;20(10):1974-83. doi: 10.1038/oby.2012.32. Epub 2012 Feb 13.
14. NAD(+) in aging, metabolism, and neurodegeneration. Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
15. CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease. Weir HJ, etal., PLoS One. 2012;7(11):e48225. doi: 10.1371/journal.pone.0048225. Epub 2012 Nov 6.
16. Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model. Zeng L, etal., PLoS One. 2014 Feb 4;9(2):e88019. doi: 10.1371/journal.pone.0088019. eCollection 2014.
Additional References at PubMed
PMID:11056054   PMID:12186850   PMID:12477932   PMID:16079181   PMID:16788062   PMID:16790548   PMID:17923681   PMID:18054327   PMID:18614015   PMID:19241369   PMID:19535340   PMID:20413424  
PMID:21419014   PMID:21867412   PMID:22309213   PMID:23201401   PMID:23283301   PMID:23576753   PMID:24239092   PMID:24535021   PMID:25210848   PMID:25284742   PMID:25433241   PMID:25483313  
PMID:25759382   PMID:25877446   PMID:25993470   PMID:26225774   PMID:26523980   PMID:26620563   PMID:26767982   PMID:27067422   PMID:27212443   PMID:27423420   PMID:27449933   PMID:27614093  
PMID:27888691   PMID:27890624   PMID:28003866   PMID:28053989   PMID:28296029   PMID:28396174   PMID:28579116   PMID:28760678   PMID:29445193   PMID:29857817   PMID:29863652   PMID:30132522  
PMID:30216853   PMID:30385301   PMID:30502252   PMID:30717220   PMID:30764676   PMID:30849417   PMID:31696493   PMID:32139662   PMID:32141452   PMID:32426865   PMID:32506069   PMID:32507768  
PMID:32805255   PMID:32818702   PMID:33127810   PMID:33522075   PMID:33565085   PMID:33665656   PMID:33823364   PMID:34082675   PMID:34296964   PMID:34330062   PMID:34360775   PMID:35192161  
PMID:35953459   PMID:36153454   PMID:36262283   PMID:36380567   PMID:36481985   PMID:36863620   PMID:36916106   PMID:36922709   PMID:37335200   PMID:37988067   PMID:38122862   PMID:38134189  
PMID:38139395   PMID:38301949  


Genomics

Comparative Map Data
Sirt3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81205,371,703 - 205,394,145 (-)NCBIGRCr8
mRatBN7.21195,942,066 - 195,964,472 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1195,942,073 - 195,964,808 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1204,294,536 - 204,318,293 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01211,421,447 - 211,445,196 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01204,095,300 - 204,119,047 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01213,613,502 - 213,636,061 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,613,513 - 213,635,546 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,539,132 - 220,561,380 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41201,021,391 - 201,043,756 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11201,172,601 - 201,193,816 (-)NCBI
Celera1193,586,014 - 193,607,810 (-)NCBICelera
Cytogenetic Map1q41NCBI
SIRT3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811215,030 - 236,931 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11215,030 - 236,931 (-)EnsemblGRCh38hg38GRCh38
GRCh3711215,030 - 236,931 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611205,030 - 226,362 (-)NCBINCBI36Build 36hg18NCBI36
Build 3411206,138 - 226,416NCBI
Celera11322,773 - 343,832 (+)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef1135,047 - 56,030 (-)NCBIHuRef
CHM1_111213,704 - 234,799 (-)NCBICHM1_1
T2T-CHM13v2.011256,228 - 277,937 (-)NCBIT2T-CHM13v2.0
Sirt3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,443,576 - 140,462,222 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7140,443,579 - 140,462,222 (-)EnsemblGRCm39 Ensembl
GRCm387140,863,663 - 140,882,309 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,863,666 - 140,882,309 (-)EnsemblGRCm38mm10GRCm38
MGSCv377148,049,562 - 148,068,208 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367140,714,990 - 140,733,629 (-)NCBIMGSCv36mm8
Celera7140,655,950 - 140,674,596 (-)NCBICelera
Cytogenetic Map7F4- F5NCBI
cM Map786.07NCBI
Sirt3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547611,794,951 - 11,826,237 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547611,794,951 - 11,826,244 (+)NCBIChiLan1.0ChiLan1.0
SIRT3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v292,582,959 - 2,605,626 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1111,737,925 - 1,761,366 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011210,052 - 233,969 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111255,191 - 863,031 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11255,191 - 278,732 (-)Ensemblpanpan1.1panPan2
SIRT3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,369,183 - 25,388,126 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1825,369,382 - 25,388,118 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,019,130 - 25,038,115 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01825,895,720 - 25,914,839 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1825,895,722 - 25,914,795 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11825,463,734 - 25,482,834 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,108,512 - 25,127,612 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,721,366 - 25,740,351 (-)NCBIUU_Cfam_GSD_1.0
Sirt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494763,131 - 78,513 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493688863,546 - 77,950 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493688863,131 - 78,536 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIRT3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl238,464 - 55,101 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1238,465 - 55,074 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22162,169,820 - 162,186,214 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIRT3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1125,740 - 49,471 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl126,927 - 48,944 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603897,040,657 - 97,063,458 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sirt3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476622,199,601 - 22,233,933 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476622,199,741 - 22,233,933 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Sirt3
106 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:48
Interacting mature miRNAs:53
Transcripts:ENSRNOT00000018861
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169537671214537671Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1151646613196646613Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1158633083203633083Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1144017057197814409Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1181746937196383668Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164747424209747424Rat
619613Bp77Blood pressure QTL 770.01arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1164747424209747424Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1169112897197261052Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1169112897197261052Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1173108781218108781Rat
631260Tcas2Tongue tumor susceptibility QTL 24.93tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)1192485903199050587Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1144267353196383668Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1174133260219133260Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1150700142252085212Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1181759564214537555Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1169537671214537671Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1144267353222987745Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1174133260196383668Rat
737977Bp160Blood pressure QTL 1600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1181133855226133855Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642644214537671Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1176426412257976495Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1184550676229550676Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1182623426219932796Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1178810256240830002Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1193422268214537671Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1185145134221264292Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1156677124256448636Rat
1302787Stl25Serum triglyceride level QTL 252.70.0073blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1180359209210702199Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1151162512201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1156677124201278233Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512201278233Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1177227632256448636Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1151162512201278233Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1151162512201278233Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1151162512256448636Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1177227632256448636Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1167909849212909849Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1151162512256448636Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1185356336202902618Rat
1558658Bw59Body weight QTL 593.50.0003body mass (VT:0001259)body weight (CMO:0000012)1178784622223784622Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1153136852260522016Rat
1358191Ept10Estrogen-induced pituitary tumorigenesis QTL 103.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)1192825253243914732Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1151162766225824951Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1191019702246062233Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1172609619217609619Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1171310381216310381Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1188377360224054420Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1143506580212458660Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1176550523221550523Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1195804352257091168Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1195804352257091168Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1150700247252085048Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1179567751260522016Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1150700247252085048Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393243914901Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1164310393213533942Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1181829673224569684Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1144267353251128347Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1171629477216629477Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1171629477216629477Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1171629477216629477Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1171629477216629477Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1171629477216629477Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1171629477216629477Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1171629477216629477Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1156677124218753816Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1185356336231689108Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1154561505199561505Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1155866514200866514Rat
6480780Insul18Insulin level QTL 184.11blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1189607473200611765Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1180359209218108781Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1183970203243914901Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1149448574221264292Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1193113876238113876Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1183970203243914901Rat
10059590Kidm44Kidney mass QTL 443.420.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1191033875236033875Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1176869060221869060Rat

Markers in Region
RH133909  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21195,942,227 - 195,942,434 (+)MAPPERmRatBN7.2
Rnor_6.01213,613,664 - 213,613,870NCBIRnor6.0
Rnor_5.01220,539,295 - 220,539,501UniSTSRnor5.0
RGSC_v3.41201,021,549 - 201,021,755UniSTSRGSC3.4
Celera1193,586,172 - 193,586,378UniSTS
Cytogenetic Map1q41UniSTS
Sirt3  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21195,954,054 - 195,955,352 (+)MAPPERmRatBN7.2
Rnor_6.01213,625,491 - 213,626,788NCBIRnor6.0
Rnor_5.01220,551,122 - 220,552,419UniSTSRnor5.0
Celera1193,597,830 - 193,599,127UniSTS
Cytogenetic Map1q41UniSTS


Genetic Models
This gene Sirt3 is modified in the following models/strains:


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 16 41 3 6 74 35 41 11 3
Low 3 5 5 5
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001106313 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006230526 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008759981 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107856 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286515 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286517 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286525 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286529 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC109844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC167006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473953 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  EU886468 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000018861   ⟹   ENSRNOP00000018861
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,942,077 - 195,964,071 (-)Ensembl
Rnor_6.0 Ensembl1213,613,513 - 213,635,546 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000095396   ⟹   ENSRNOP00000089047
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,942,073 - 195,958,082 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116448   ⟹   ENSRNOP00000078101
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1195,942,073 - 195,964,808 (-)Ensembl
RefSeq Acc Id: NM_001106313   ⟹   NP_001099783
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,601 (-)NCBI
mRatBN7.21195,942,070 - 195,963,970 (-)NCBI
Rnor_6.01213,613,506 - 213,635,512 (-)NCBI
Rnor_5.01220,539,132 - 220,561,380 (-)NCBI
RGSC_v3.41201,021,391 - 201,043,756 (-)RGD
Celera1193,586,014 - 193,607,810 (-)RGD
Sequence:
RefSeq Acc Id: XM_006230526   ⟹   XP_006230588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,697 (-)NCBI
mRatBN7.21195,942,066 - 195,964,047 (-)NCBI
Rnor_6.01213,613,502 - 213,635,601 (-)NCBI
Rnor_5.01220,539,132 - 220,561,380 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039107846   ⟹   XP_038963774
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,394,103 (-)NCBI
mRatBN7.21195,942,068 - 195,964,472 (-)NCBI
RefSeq Acc Id: XM_039107856   ⟹   XP_038963784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,651 (-)NCBI
mRatBN7.21195,942,066 - 195,964,048 (-)NCBI
RefSeq Acc Id: XM_063286513   ⟹   XP_063142583
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,877 (-)NCBI
RefSeq Acc Id: XM_063286515   ⟹   XP_063142585
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,697 (-)NCBI
RefSeq Acc Id: XM_063286517   ⟹   XP_063142587
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,393,113 (-)NCBI
RefSeq Acc Id: XM_063286519   ⟹   XP_063142589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,386,763 (-)NCBI
RefSeq Acc Id: XM_063286525   ⟹   XP_063142595
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,394,145 (-)NCBI
RefSeq Acc Id: XM_063286528   ⟹   XP_063142598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,394,145 (-)NCBI
RefSeq Acc Id: XM_063286529   ⟹   XP_063142599
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81205,371,703 - 205,394,145 (-)NCBI
RefSeq Acc Id: NP_001099783   ⟸   NM_001106313
- UniProtKB: B2RZ31 (UniProtKB/TrEMBL),   A0A8I6A7C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006230588   ⟸   XM_006230526
- Peptide Label: isoform X2
- UniProtKB: F7EYD5 (UniProtKB/TrEMBL),   C6ZII9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000018861   ⟸   ENSRNOT00000018861
RefSeq Acc Id: XP_038963784   ⟸   XM_039107856
- Peptide Label: isoform X5
- UniProtKB: A6HXL1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038963774   ⟸   XM_039107846
- Peptide Label: isoform X4
- UniProtKB: B2RZ31 (UniProtKB/TrEMBL),   A0A8I6A7C4 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000078101   ⟸   ENSRNOT00000116448
RefSeq Acc Id: ENSRNOP00000089047   ⟸   ENSRNOT00000095396
RefSeq Acc Id: XP_063142595   ⟸   XM_063286525
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063142599   ⟸   XM_063286529
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063142598   ⟸   XM_063286528
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063142583   ⟸   XM_063286513
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063142585   ⟸   XM_063286515
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063142587   ⟸   XM_063286517
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063142589   ⟸   XM_063286519
- Peptide Label: isoform X4
Protein Domains
Deacetylase sirtuin-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-C6ZII9-F1-model_v2 AlphaFold C6ZII9 1-320 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690520
Promoter ID:EPDNEW_R1044
Type:multiple initiation site
Name:Sirt3_1
Description:sirtuin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01213,635,546 - 213,635,606EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308374 AgrOrtholog
BioCyc Gene G2FUF-57005 BioCyc
Ensembl Genes ENSRNOG00000013828 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000018861.7 UniProtKB/TrEMBL
  ENSRNOT00000095396 ENTREZGENE
  ENSRNOT00000095396.1 UniProtKB/TrEMBL
  ENSRNOT00000116448.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1600.10 UniProtKB/TrEMBL
  TPP-binding domain UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7314283 IMAGE-MGC_LOAD
InterPro DHS-like_NAD/FAD-binding_dom UniProtKB/TrEMBL
  NAD-dep_deAcase_SIR2_euk UniProtKB/TrEMBL
  NAD-dep_histone_deAcase_SIR2 UniProtKB/TrEMBL
  Sirtuin_cat_small_dom_sf UniProtKB/TrEMBL
  Ssirtuin_cat_dom UniProtKB/TrEMBL
KEGG Report rno:293615 UniProtKB/TrEMBL
MGC_CLONE MGC:189177 IMAGE-MGC_LOAD
NCBI Gene 293615 ENTREZGENE
PANTHER NAD-DEPENDENT HISTONE DEACETYLASE HST4 UniProtKB/TrEMBL
  NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL UniProtKB/TrEMBL
Pfam SIR2 UniProtKB/TrEMBL
PhenoGen Sirt3 PhenoGen
PIRSF SIR2_euk UniProtKB/TrEMBL
PROSITE SIRTUIN UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013828 RatGTEx
Superfamily-SCOP SSF52467 UniProtKB/TrEMBL
UniProt A0A8I5XWT5_RAT UniProtKB/TrEMBL
  A0A8I6A7C4 ENTREZGENE, UniProtKB/TrEMBL
  A6HXL1 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ31 ENTREZGENE, UniProtKB/TrEMBL
  C6ZII9 ENTREZGENE, UniProtKB/TrEMBL
  F7EYD5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Sirt3  sirtuin 3  Sirt3  sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-10-23 Sirt3  sirtuin (silent mating type information regulation 2 homolog) 3 (S. cerevisiae)  Sirt3  sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Sirt3  sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)   Sirt3_predicted  sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Sirt3_predicted  sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED