Igf2r (insulin-like growth factor 2 receptor) - Rat Genome Database

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Gene: Igf2r (insulin-like growth factor 2 receptor) Rattus norvegicus
Symbol: Igf2r
Name: insulin-like growth factor 2 receptor
RGD ID: 2871
Description: Enables several functions, including G-protein alpha-subunit binding activity; insulin-like growth factor II binding activity; and retinoic acid binding activity. Involved in several processes, including animal organ regeneration; response to retinoic acid; and response to tetrachloromethane. Located in extracellular space; late endosome; and perinuclear region of cytoplasm. Part of clathrin coat. Colocalizes with trans-Golgi network. Used to study lung adenocarcinoma. Biomarker of amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor); PARTICIPATES IN renin-angiotensin cascade pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cation-independent mannose-6-phosphate receptor; IGF-IIR; Igfr2
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8150,526,878 - 50,615,265 (+)NCBIGRCr8
mRatBN7.2147,979,109 - 48,067,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,979,109 - 48,067,501 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,670,745 - 48,759,134 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,656,245 - 54,744,657 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,746,270 - 48,834,659 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,176,095 - 48,264,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,176,106 - 48,264,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,488,767 - 51,577,141 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,253,273 - 42,341,646 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,256,217 - 42,344,589 (+)NCBI
Celera143,778,518 - 43,867,238 (+)NCBICelera
Cytogenetic Map1q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2,4-trimethylbenzene  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetylsalicylic acid  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
aldehydo-D-glucose  (EXP)
all-trans-retinoic acid  (EXP,ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
Butylparaben  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (EXP)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP)
chloroacetaldehyde  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
cidofovir anhydrous  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
enzacamene  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (EXP)
erythromycin estolate  (EXP)
ethanol  (ISO)
fenofibrate  (EXP)
fenthion  (ISO)
finasteride  (EXP)
fipronil  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (EXP,ISO)
genistein  (ISO)
gentamycin  (EXP)
glucose  (EXP)
ifosfamide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
kojic acid  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP)
manganese(II) chloride  (EXP)
menadione  (ISO)
metformin  (EXP,ISO)
methidathion  (ISO)
methimazole  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nitrofen  (EXP)
ozone  (ISO)
p-menthan-3-ol  (ISO)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (EXP,ISO)
prochloraz  (EXP)
procymidone  (EXP)
resveratrol  (ISO)
rotenone  (ISO)
Salinomycin  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
streptozocin  (EXP)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sunitinib  (ISO)
Tanshinone I  (EXP)
temozolomide  (ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
Tributyltin oxide  (EXP,ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
# Reference Title Reference Citation
1. Changes in distribution of phosphomannosyl receptors during maturation of rat spermatozoa. Belmonte SA, etal., Biol Reprod. 2000 Oct;63(4):1172-8.
2. Activation of insulin-like growth factor II receptor induces mitochondrial-dependent apoptosis through G(alpha)q and downstream calcineurin signaling in myocardial cells. Chu CH, etal., Endocrinology. 2009 Jun;150(6):2723-31. Epub 2008 Dec 18.
3. A highly phosphorylated subpopulation of insulin-like growth factor II/mannose 6-phosphate receptors is concentrated in a clathrin-enriched plasma membrane fraction. Corvera S, etal., Proc Natl Acad Sci U S A. 1988 Oct;85(20):7567-71.
4. Up-regulation of insulin-like growth factor-II receptor in reactive astrocytes in the spinal cord of amyotrophic lateral sclerosis transgenic rats. Dagvajantsan B, etal., Tohoku J Exp Med. 2008 Apr;214(4):303-10.
5. M6P/IGF2R gene is mutated in human hepatocellular carcinomas with loss of heterozygosity. De Souza AT, etal., Nat Genet. 1995 Dec;11(4):447-9.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. M6P/IGF2 receptor: a candidate breast tumor suppressor gene. Hankins GR, etal., Oncogene. 1996 May 2;12(9):2003-9.
9. Insulin-like growth factor-II/mannose-6-phosphate receptor: widespread distribution in neurons of the central nervous system including those expressing cholinergic phenotype. Hawkes C and Kar S, J Comp Neurol 2003 Mar 31;458(2):113-27.
10. Single transmembrane domain insulin-like growth factor-II/mannose-6-phosphate receptor regulates central cholinergic function by activating a G-protein-sensitive, protein kinase C-dependent pathway. Hawkes C, etal., J Neurosci. 2006 Jan 11;26(2):585-96.
11. 3-Methyladenine specifically inhibits retrograde transport of cation-independent mannose 6-phosphate/insulin-like growth factor II receptor from the early endosome to the TGN. Hirosako K, etal., Biochem Biophys Res Commun. 2004 Apr 9;316(3):845-52.
12. Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma. Jang HS, etal., World J Gastroenterol. 2008 Mar 7;14(9):1394-8. doi: 10.3748/wjg.14.1394.
13. Organ-specific changes in the expression of mannose-6-phosphate receptors during postnatal development in rats. Jofre GF, etal., Cells Tissues Organs. 2009;190(1):27-33. Epub 2008 Sep 30.
14. Mannose 6-phosphate/insulin-like growth factor II receptor mediates the growth-inhibitory effects of retinoids. Kang JX, etal., Cell Growth Differ. 1999 Aug;10(8):591-600.
15. Retinoic acid alters the intracellular trafficking of the mannose-6-phosphate/insulin-like growth factor II receptor and lysosomal enzymes. Kang JX, etal., Proc Natl Acad Sci U S A. 1998 Nov 10;95(23):13687-91.
16. Loss of the imprinted IGF2/cation-independent mannose 6-phosphate receptor results in fetal overgrowth and perinatal lethality. Lau MM, etal., Genes Dev 1994 Dec 15;8(24):2953-63.
17. Expression and prognostic significance of insulin‑like growth factor-2 receptor in human hepatocellular carcinoma and the influence of transarterial chemoembolization. Lautem A, etal., Oncol Rep. 2019 Apr;41(4):2299-2310. doi: 10.3892/or.2019.6995. Epub 2019 Feb 1.
18. Roles of insulin-like growth factor II in cardiomyoblast apoptosis and in hypertensive rat heart with abdominal aorta ligation. Lee SD, etal., Am J Physiol Endocrinol Metab. 2006 Aug;291(2):E306-14.
19. A single receptor binds both insulin-like growth factor II and mannose-6-phosphate. MacDonald RG, etal., Science 1988 Mar 4;239(4844):1134-7.
20. The insulin-like growth factor-II receptor gene is associated with type 1 diabetes: evidence of a maternal effect. McCann JA, etal., J Clin Endocrinol Metab. 2004 Nov;89(11):5700-6.
21. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
22. Imprinted M6p/Igf2 receptor is mutated in rat liver tumors. Mills JJ, etal., Oncogene. 1998 May 28;16(21):2797-802.
23. In vitro reconstitution of fusion between immature autophagosomes and endosomes. Morvan J, etal., Autophagy. 2009 Jul;5(5):676-89. Epub 2009 Jul 6.
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Renin/prorenin receptors. Nguyen G, Kidney Int. 2006 May;69(9):1503-6.
26. M6P/IGF2R tumor suppressor gene mutated in hepatocellular carcinomas in Japan. Oka Y, etal., Hepatology. 2002 May;35(5):1153-63. doi: 10.1053/jhep.2002.32669.
27. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
28. Changes in IGF-I and -II, IGF binding protein, and IGF receptor transcript abundance after uterine artery ligation. Price WA, etal., Pediatr Res. 1992 Sep;32(3):291-5. doi: 10.1203/00006450-199209000-00009.
29. GOA pipeline RGD automated data pipeline
30. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
32. Expression and binding properties of the two mannose-6-phosphate receptors differ during perinatal development in rat liver. Romano PS, etal., Biochem Biophys Res Commun. 2002 Jul 26;295(4):1000-6.
33. Changes in the mRNA expressions of insulin-like growth factors, their receptors, and binding proteins during the postnatal development of rat masseter muscle. Saito T, etal., Zoolog Sci 2003 Apr;20(4):441-7.
34. High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin. Saris JJ, etal., Am J Physiol Heart Circ Physiol. 2001 Apr;280(4):H1706-15.
35. Mutations in the IGF-II pathway that confer resistance to lytic reovirus infection. Sheng J, etal., BMC Cell Biol. 2004 Aug 27;5:32.
36. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
37. Alterations of the M6p/Igf2 receptor gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats. Tsujiuchi T, etal., Mol Carcinog 2003 Jan;36(1):32-7.
38. Alterations of the M6p/Igf2 receptor gene in hepatocellular carcinomas induced by N-nitrosodiethylamine and a choline-deficient L-amino acid-defined diet in rats. Tsujiuchi T, etal., Mol Carcinog. 2004 Apr;39(4):199-205.
39. Serum and urinary levels of CD222 in cancer: origin and diagnostic value. Vicikova K, etal., Neoplasma. 2018 Sep 19;65(5):762-768. doi: 10.4149/neo_2018_171203N792. Epub 2018 Jun 18.
40. The hepatocyte is a direct target for transforming-growth factor beta activation via the insulin-like growth factor II/mannose 6-phosphate receptor. Villevalois-Cam L, etal., J Hepatol 2003 Feb;38(2):156-63.
41. The ACAA-insertion/deletion polymorphism at the 3' UTR of the IGF-II receptor gene is associated with type 2 diabetes and surrogate markers of insulin resistance. Villuendas G, etal., Eur J Endocrinol. 2006 Aug;155(2):331-6.
42. Failure to detect genetic alteration of the mannose-6-phosphate/insulin-like growth factor 2 receptor (M6P/IGF2R) gene in hepatocellular carcinomas in Japan. Wada I, etal., Hepatology. 1999 Jun;29(6):1718-21. doi: 10.1002/hep.510290635.
43. E-box-binding repressor is down-regulated in hepatic stellate cells during up-regulation of mannose 6-phosphate/insulin-like growth factor-II receptor expression in early hepatic fibrogenesis. Weiner JA, etal., J Biol Chem. 1998 Jun 26;273(26):15913-9. doi: 10.1074/jbc.273.26.15913.
44. Aberrant imprinting of the insulin-like growth factor II receptor gene in Wilms' tumor. Xu YQ, etal., Oncogene. 1997 Mar 6;14(9):1041-6.
45. Genetic changes and expression of the mannose 6-phosphate/insulin-like growth factor II receptor gene in human hepatitis B virus-associated hepatocellular carcinoma. Yang EB, etal., Int J Mol Med. 2003 Jun;11(6):773-8.
46. Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period. Zakaria R, etal., Acta Histochem. 2009;111(1):52-60. Epub 2008 Aug 3.
Additional References at PubMed
PMID:1298967   PMID:2963825   PMID:10900005   PMID:12729502   PMID:14566968   PMID:15078902   PMID:17959629   PMID:18817523   PMID:19056867   PMID:19764351   PMID:19946888   PMID:20889566  
PMID:21412773   PMID:21423176   PMID:21433279   PMID:21443795   PMID:22456507   PMID:22521359   PMID:22681933   PMID:23376485   PMID:23419388   PMID:23495048   PMID:23533145   PMID:24667322  
PMID:25536374   PMID:28383811   PMID:28796250   PMID:28812967   PMID:29136764   PMID:29574782   PMID:31211784   PMID:31584202   PMID:34145441   PMID:34586566   PMID:36462176   PMID:36928640  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
GRCr8150,526,878 - 50,615,265 (+)NCBIGRCr8
mRatBN7.2147,979,109 - 48,067,501 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl147,979,109 - 48,067,501 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx148,670,745 - 48,759,134 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0154,656,245 - 54,744,657 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0148,746,270 - 48,834,659 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0148,176,095 - 48,264,482 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl148,176,106 - 48,264,477 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0151,488,767 - 51,577,141 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4142,253,273 - 42,341,646 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1142,256,217 - 42,344,589 (+)NCBI
Celera143,778,518 - 43,867,238 (+)NCBICelera
Cytogenetic Map1q11NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh386159,969,082 - 160,111,504 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6159,969,082 - 160,113,507 (+)EnsemblGRCh38hg38GRCh38
GRCh376160,390,114 - 160,532,536 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366160,310,121 - 160,447,573 (+)NCBINCBI36Build 36hg18NCBI36
Build 346160,360,541 - 160,497,992NCBI
Celera6161,035,974 - 161,173,355 (+)NCBICelera
Cytogenetic Map6q25.3NCBI
HuRef6157,860,740 - 157,998,270 (+)NCBIHuRef
CHM1_16160,652,348 - 160,789,828 (+)NCBICHM1_1
T2T-CHM13v2.06161,215,266 - 161,357,599 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391712,901,293 - 12,988,593 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1712,901,293 - 12,988,551 (-)EnsemblGRCm39 Ensembl
GRCm381712,682,406 - 12,769,706 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1712,682,406 - 12,769,664 (-)EnsemblGRCm38mm10GRCm38
MGSCv371712,875,272 - 12,962,572 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361712,525,771 - 12,613,022 (-)NCBIMGSCv36mm8
Celera1712,714,412 - 12,801,753 (-)NCBICelera
Cytogenetic Map17A1NCBI
cM Map178.64NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495543920,752,855 - 20,851,281 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543920,754,915 - 20,874,759 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1-v25180,068,746 - 180,206,598 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16177,973,023 - 178,110,866 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06157,852,565 - 157,990,049 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16162,884,786 - 162,983,968 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6162,878,661 - 162,997,762 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1149,161,551 - 49,262,260 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl149,161,444 - 49,262,277 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha150,002,759 - 50,102,366 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0149,345,406 - 49,445,163 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl149,345,406 - 49,445,163 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1149,227,935 - 49,327,529 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0149,099,537 - 49,199,165 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0149,714,384 - 49,814,084 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024404946144,195,094 - 144,271,698 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648911,447,038 - 11,524,174 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648911,447,043 - 11,523,695 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl17,368,103 - 7,472,548 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.117,369,485 - 7,472,480 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.219,168,321 - 9,271,328 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.11387,587,717 - 87,723,795 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1387,587,907 - 87,724,116 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604059,978,473 - 60,111,795 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248552,753,994 - 2,887,151 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248552,752,676 - 2,887,327 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Igf2r
88 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:501
Count of miRNA genes:256
Interacting mature miRNAs:310
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat
2313051Bss57Bone structure and strength QTL 573.70.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)143284731118944897Rat
2313059Bss55Bone structure and strength QTL 553.20.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313072Bss53Bone structure and strength QTL 534.30.0001tibia length (VT:0004357)tibia length (CMO:0000450)143284731118944897Rat
2313078Bss54Bone structure and strength QTL 543.50.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)143284731118944897Rat
2313094Bss58Bone structure and strength QTL 583.70.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)143284731118944897Rat
2313098Bmd70Bone mineral density QTL 703.60.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)143284731118944897Rat
2313099Bss56Bone structure and strength QTL 562.40.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)143284731118944897Rat
2302059Pia36Pristane induced arthritis QTL 363.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)14333300288333002Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14580314078430678Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,026,370 - 48,026,559 (+)MAPPERmRatBN7.2
Rnor_6.0148,223,355 - 48,223,543NCBIRnor6.0
Rnor_5.0151,529,704 - 51,529,892UniSTSRnor5.0
RGSC_v3.4142,300,522 - 42,300,710UniSTSRGSC3.4
Celera143,826,107 - 43,826,295UniSTS
Cytogenetic Map1q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,067,163 - 48,067,372 (+)MAPPERmRatBN7.2
Rnor_6.0148,264,145 - 48,264,353NCBIRnor6.0
Rnor_5.0151,488,893 - 51,489,101UniSTSRnor5.0
RGSC_v3.4142,341,312 - 42,341,520UniSTSRGSC3.4
Celera143,866,901 - 43,867,109UniSTS
RH 3.4 Map1566.6UniSTS
Cytogenetic Map1q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2148,066,393 - 48,066,568 (+)MAPPERmRatBN7.2
Rnor_6.0148,263,375 - 48,263,549NCBIRnor6.0
Rnor_5.0151,489,697 - 51,489,871UniSTSRnor5.0
RGSC_v3.4142,340,542 - 42,340,716UniSTSRGSC3.4
Celera143,866,131 - 43,866,305UniSTS
Cytogenetic Map1q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2147,996,773 - 47,997,010 (+)MAPPERmRatBN7.2
Rnor_6.0148,193,759 - 48,193,995NCBIRnor6.0
Rnor_5.0151,559,252 - 51,559,488UniSTSRnor5.0
RGSC_v3.4142,270,926 - 42,271,162UniSTSRGSC3.4
Celera143,796,182 - 43,796,418UniSTS
RH 3.4 Map1564.0UniSTS
Cytogenetic Map1q11UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0151,488,890 - 51,489,008UniSTSRnor5.0
Cytogenetic Map1q11UniSTS


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 55 39 18 39 8 11 74 35 36 11 8
Low 2 2 1 2 5
Below cutoff


RefSeq Acc Id: ENSRNOT00000021840   ⟹   ENSRNOP00000021840
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,979,109 - 48,067,501 (+)Ensembl
Rnor_6.0 Ensembl148,176,106 - 48,264,477 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000104985   ⟹   ENSRNOP00000095398
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl148,000,044 - 48,067,501 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108241   ⟹   ENSRNOP00000092757
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl147,992,461 - 48,067,501 (+)Ensembl
RefSeq Acc Id: NM_012756   ⟹   NP_036888
RefSeq Status: VALIDATED
Rat AssemblyChrPosition (strand)Source
GRCr8150,526,878 - 50,615,265 (+)NCBI
mRatBN7.2147,979,109 - 48,067,501 (+)NCBI
Rnor_6.0148,176,095 - 48,264,482 (+)NCBI
Rnor_5.0151,488,767 - 51,577,141 (-)NCBI
RGSC_v3.4142,253,273 - 42,341,646 (+)RGD
Celera143,778,518 - 43,867,238 (+)NCBI
RefSeq Acc Id: NP_036888   ⟸   NM_012756
- Peptide Label: precursor
- UniProtKB: G3V824 (UniProtKB/TrEMBL),   A6KJW4 (UniProtKB/TrEMBL),   Q63002 (UniProtKB/TrEMBL),   Q63757 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021840   ⟸   ENSRNOT00000021840
RefSeq Acc Id: ENSRNOP00000092757   ⟸   ENSRNOT00000108241
RefSeq Acc Id: ENSRNOP00000095398   ⟸   ENSRNOT00000104985
Protein Domains
Fibronectin type-II   MRH

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V824-F1-model_v2 AlphaFold G3V824 1-2481 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13689617
Promoter ID:EPDNEW_R142
Type:initiation region
Description:insulin-like growth factor 2 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0148,176,088 - 48,176,148EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2871 AgrOrtholog
BioCyc Gene G2FUF-61574 BioCyc
Ensembl Genes ENSRNOG00000014997 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000021840 ENTREZGENE
  ENSRNOT00000021840.5 UniProtKB/TrEMBL
  ENSRNOT00000104985.1 UniProtKB/TrEMBL
  ENSRNOT00000108241.1 UniProtKB/TrEMBL
InterPro CIMR UniProtKB/TrEMBL
  FN_type2_col-bd UniProtKB/TrEMBL
  FN_type2_sf UniProtKB/TrEMBL
  Kringle-like UniProtKB/TrEMBL
  Man6P_isomerase_rcpt-bd UniProtKB/TrEMBL
  MRH_dom UniProtKB/TrEMBL
KEGG Report rno:25151 UniProtKB/TrEMBL
  fn2 UniProtKB/TrEMBL
PhenoGen Igf2r PhenoGen
  FN2_2 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000014997 RatGTEx
  FN2 UniProtKB/TrEMBL
Superfamily-SCOP Kringle-like UniProtKB/TrEMBL
  SSF50911 UniProtKB/TrEMBL
TIGR TC216531
UniProt A0A8I6AI55_RAT UniProtKB/TrEMBL
UniProt Secondary Q63757 UniProtKB/TrEMBL

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Igf2r  insulin-like growth factor 2 receptor      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process required for cytotoxic T cell-mediated apoptosis and rejection of allogeneic cells  
gene_process involved in suppression of several carcinomas