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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Sirt7 | Rat | (-)-epigallocatechin 3-gallate | affects methylation | EXP | | 6480464 | epigallocatechin gallate affects the methylation of SIRT7 gene | CTD | PMID:29381301 | Sirt7 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Sirt7 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SIRT7 mRNA | CTD | PMID:22206623 | Sirt7 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Sirt7 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to SIRT7 promoter] | CTD | PMID:19654925 | Sirt7 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SIRT7 mRNA | CTD | PMID:33387578 | Sirt7 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of SIRT7 mRNA | CTD | PMID:34747641 | Sirt7 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SIRT7 mRNA | CTD | PMID:20106945 and PMID:21632981 | Sirt7 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Sirt7 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SIRT7 mRNA | CTD | PMID:21570461 | Sirt7 | Rat | acrolein | multiple interactions | ISO | SIRT7 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of SIRT7 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of SIRT7 mRNA | CTD | PMID:32699268 | Sirt7 | Rat | acrylamide | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Acrylamide results in increased expression of SIRT7 mRNA | CTD | PMID:32763439 | Sirt7 | Rat | aldehydo-D-glucose | multiple interactions | ISO | Sirt7 (Mus musculus) | 6480464 | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT7 mRNA more ... | CTD | PMID:28675767 | Sirt7 | Rat | alpha-pinene | multiple interactions | ISO | SIRT7 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of SIRT7 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of SIRT7 mRNA | CTD | PMID:32699268 | Sirt7 | Rat | aristolochic acid A | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | aristolochic acid I results in increased expression of SIRT7 mRNA | CTD | PMID:33212167 | Sirt7 | Rat | atrazine | decreases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Atrazine results in decreased expression of SIRT7 mRNA | CTD | PMID:22378314 | Sirt7 | Rat | benzo[a]pyrene | increases expression | ISO | Sirt7 (Mus musculus) | 6480464 | Benzo(a)pyrene results in increased expression of SIRT7 mRNA | CTD | PMID:21569818 and PMID:22228805 | Sirt7 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SIRT7 mRNA | CTD | PMID:25181051 more ... | Sirt7 | Rat | bisphenol A | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of SIRT7 mRNA | CTD | PMID:32030086 | Sirt7 | Rat | bisphenol A | decreases expression | ISO | Sirt7 (Mus musculus) | 6480464 | bisphenol A results in decreased expression of SIRT7 mRNA | CTD | PMID:35598803 | Sirt7 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of SIRT7 mRNA | CTD | PMID:30816183 | Sirt7 | Rat | bisphenol A | increases expression | ISO | Sirt7 (Mus musculus) | 6480464 | bisphenol A results in increased expression of SIRT7 mRNA | CTD | PMID:31016965 | Sirt7 | Rat | bisphenol A | decreases methylation | ISO | Sirt7 (Mus musculus) | 6480464 | bisphenol A results in decreased methylation of SIRT7 promoter | CTD | PMID:27312807 | Sirt7 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of SIRT7 gene | CTD | PMID:28505145 | Sirt7 | Rat | Butylbenzyl phthalate | decreases expression | ISO | Sirt7 (Mus musculus) | 6480464 | butylbenzyl phthalate results in decreased expression of SIRT7 mRNA | CTD | PMID:27923775 | Sirt7 | Rat | Butylbenzyl phthalate | affects expression | ISO | Sirt7 (Mus musculus) | 6480464 | butylbenzyl phthalate affects the expression of SIRT7 mRNA | CTD | PMID:31016965 | Sirt7 | Rat | cadmium atom | affects methylation | EXP | | 6480464 | Cadmium affects the methylation of SIRT7 gene | CTD | PMID:29381301 | Sirt7 | Rat | CGP 52608 | multiple interactions | ISO | SIRT7 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SIRT7 gene] | CTD | PMID:28238834 | Sirt7 | Rat | chlordecone | increases expression | ISO | Sirt7 (Mus musculus) | 6480464 | Chlordecone results in increased expression of SIRT7 mRNA | CTD | PMID:33711761 | Sirt7 | Rat | cisplatin | increases expression | ISO | Sirt7 (Mus musculus) | 6480464 | Cisplatin results in increased expression of SIRT7 mRNA | CTD | PMID:21151649 | Sirt7 | Rat | clofibrate | decreases expression | ISO | Sirt7 (Mus musculus) | 6480464 | Clofibrate results in decreased expression of SIRT7 mRNA | CTD | PMID:23811191 | Sirt7 | Rat | cobalt dichloride | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | cobaltous chloride results in increased expression of SIRT7 mRNA | CTD | PMID:19376846 | Sirt7 | Rat | copper(II) chloride | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | cupric chloride results in increased expression of SIRT7 mRNA | CTD | PMID:17211630 | Sirt7 | Rat | copper(II) sulfate | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Copper Sulfate results in increased expression of SIRT7 mRNA | CTD | PMID:19549813 | Sirt7 | Rat | curcumin | decreases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Curcumin results in decreased expression of SIRT7 | CTD | PMID:25644192 | Sirt7 | Rat | cyclosporin A | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Cyclosporine results in increased expression of SIRT7 mRNA | CTD | PMID:25562108 | Sirt7 | Rat | D-glucose | multiple interactions | ISO | Sirt7 (Mus musculus) | 6480464 | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT7 mRNA more ... | CTD | PMID:28675767 | Sirt7 | Rat | dioxygen | multiple interactions | ISO | Sirt7 (Mus musculus) | 6480464 | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT7 mRNA more ... | CTD | PMID:28675767 | Sirt7 | Rat | folic acid | multiple interactions | ISO | Sirt7 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SIRT7 mRNA | CTD | PMID:22206623 | Sirt7 | Rat | glucose | multiple interactions | ISO | Sirt7 (Mus musculus) | 6480464 | [Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of SIRT7 mRNA more ... | CTD | PMID:28675767 | Sirt7 | Rat | Licochalcone B | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | licochalcone B results in increased expression of SIRT7 mRNA | CTD | PMID:33647349 | Sirt7 | Rat | metformin | decreases expression | ISO | Sirt7 (Mus musculus) | 6480464 | Metformin results in decreased expression of SIRT7 mRNA | CTD | PMID:24687991 | Sirt7 | Rat | methamphetamine | increases expression | ISO | Sirt7 (Mus musculus) | 6480464 | Methamphetamine results in increased expression of SIRT7 mRNA | CTD | PMID:26307267 | Sirt7 | Rat | methamphetamine | increases methylation | ISO | Sirt7 (Mus musculus) | 6480464 | Methamphetamine results in increased methylation of SIRT7 promoter | CTD | PMID:26307267 | Sirt7 | Rat | mono(2-ethylhexyl) phthalate | decreases expression | ISO | Sirt7 (Mus musculus) | 6480464 | mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT7 mRNA and mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT7 protein | CTD | PMID:31016965 | Sirt7 | Rat | NORCANTHARIDIN | multiple interactions | ISO | SIRT7 (Homo sapiens) | 6480464 | [norcantharidin co-treated with Paclitaxel] results in decreased expression of and affects the localization of SIRT7 protein more ... | CTD | PMID:34272796 | Sirt7 | Rat | NORCANTHARIDIN | decreases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | norcantharidin results in decreased expression of SIRT7 mRNA and norcantharidin results in decreased expression of SIRT7 protein | CTD | PMID:34272796 | Sirt7 | Rat | ozone | multiple interactions | ISO | SIRT7 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of SIRT7 mRNA more ... | CTD | PMID:32699268 and PMID:35430440 | Sirt7 | Rat | paclitaxel | multiple interactions | ISO | SIRT7 (Homo sapiens) | 6480464 | [norcantharidin co-treated with Paclitaxel] results in decreased expression of and affects the localization of SIRT7 protein more ... | CTD | PMID:34272796 | Sirt7 | Rat | paclitaxel | decreases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Paclitaxel results in decreased expression of SIRT7 mRNA and Paclitaxel results in decreased expression of SIRT7 protein | CTD | PMID:34272796 | Sirt7 | Rat | paracetamol | affects expression | ISO | Sirt7 (Mus musculus) | 6480464 | Acetaminophen affects the expression of SIRT7 mRNA | CTD | PMID:17562736 | Sirt7 | Rat | paracetamol | affects methylation | EXP | | 6480464 | Acetaminophen affects the methylation of SIRT7 gene | CTD | PMID:29381301 | Sirt7 | Rat | paracetamol | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of SIRT7 mRNA | CTD | PMID:25704631 | Sirt7 | Rat | perfluorooctanoic acid | affects expression | ISO | Sirt7 (Mus musculus) | 6480464 | perfluorooctanoic acid affects the expression of SIRT7 mRNA | CTD | PMID:31016965 | Sirt7 | Rat | pirinixic acid | decreases expression | ISO | Sirt7 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of SIRT7 mRNA | CTD | PMID:18445702 and PMID:23811191 | Sirt7 | Rat | propiconazole | decreases expression | ISO | Sirt7 (Mus musculus) | 6480464 | propiconazole results in decreased expression of SIRT7 mRNA | CTD | PMID:21278054 | Sirt7 | Rat | quercetin | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Quercetin results in increased expression of SIRT7 mRNA | CTD | PMID:21632981 | Sirt7 | Rat | sodium arsenite | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of SIRT7 mRNA | CTD | PMID:38568856 | Sirt7 | Rat | sunitinib | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of SIRT7 mRNA | CTD | PMID:31533062 | Sirt7 | Rat | tamoxifen | decreases expression | ISO | Sirt7 (Mus musculus) | 6480464 | Tamoxifen results in decreased expression of SIRT7 mRNA | CTD | PMID:17555576 | Sirt7 | Rat | tetrachloromethane | decreases expression | ISO | Sirt7 (Mus musculus) | 6480464 | Carbon Tetrachloride results in decreased expression of SIRT7 mRNA | CTD | PMID:31919559 | Sirt7 | Rat | thapsigargin | multiple interactions | ISO | Sirt7 (Mus musculus) | 6480464 | XBP1 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of SIRT7 mRNA] and XBP1 gene mutant form inhibits the reaction [Thapsigargin results in increased expression of SIRT7 protein] | CTD | PMID:24210820 | Sirt7 | Rat | thapsigargin | increases expression | ISO | Sirt7 (Mus musculus) | 6480464 | Thapsigargin results in increased expression of SIRT7 mRNA and Thapsigargin results in increased expression of SIRT7 protein | CTD | PMID:24210820 | Sirt7 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SIRT7 mRNA | CTD | PMID:23411599 | Sirt7 | Rat | thiram | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Thiram results in increased expression of SIRT7 mRNA | CTD | PMID:38568856 | Sirt7 | Rat | titanium dioxide | decreases methylation | ISO | Sirt7 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of SIRT7 gene | CTD | PMID:35295148 | Sirt7 | Rat | triphenyl phosphate | affects expression | ISO | SIRT7 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SIRT7 mRNA | CTD | PMID:37042841 | Sirt7 | Rat | triptonide | increases expression | ISO | Sirt7 (Mus musculus) | 6480464 | triptonide results in increased expression of SIRT7 mRNA | CTD | PMID:33045310 | Sirt7 | Rat | tunicamycin | multiple interactions | ISO | SIRT7 (Homo sapiens) | 6480464 | SIRT7 protein inhibits the reaction [Tunicamycin results in increased expression of DDIT3 mRNA] more ... | CTD | PMID:24210820 | Sirt7 | Rat | tunicamycin | increases expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Tunicamycin results in increased expression of SIRT7 mRNA and Tunicamycin results in increased expression of SIRT7 protein | CTD | PMID:24210820 | Sirt7 | Rat | valproic acid | increases methylation | ISO | SIRT7 (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of SIRT7 gene | CTD | PMID:29154799 | Sirt7 | Rat | valproic acid | increases expression | ISO | Sirt7 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of SIRT7 mRNA | CTD | PMID:19136453 and PMID:21427059 | Sirt7 | Rat | valproic acid | affects expression | ISO | SIRT7 (Homo sapiens) | 6480464 | Valproic Acid affects the expression of SIRT7 mRNA | CTD | PMID:25979313 | Sirt7 | Rat | very-low-density lipoprotein triglyceride | decreases secretion | ISO | Sirt7 (Mus musculus) | 6480464 | SIRT7 gene mutant form results in decreased secretion of very low density lipoprotein triglyceride | CTD | PMID:24210820 | Sirt7 | Rat | vinclozolin | increases expression | EXP | | 6480464 | vinclozolin results in increased expression of SIRT7 mRNA | CTD | PMID:22570695 | |