RGD Reference Report - NAD(+) in aging, metabolism, and neurodegeneration. - Rat Genome Database

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NAD(+) in aging, metabolism, and neurodegeneration.

Authors: Verdin, E 
Citation: Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
RGD ID: 11100032
Pubmed: PMID:26785480   (View Abstract at PubMed)
DOI: DOI:10.1126/science.aac4854   (Journal Full-text)

Nicotinamide adenine dinucleotide (NAD(+)) is a coenzyme found in all living cells. It serves both as a critical coenzyme for enzymes that fuel reduction-oxidation reactions, carrying electrons from one reaction to another, and as a cosubstrate for other enzymes such as the sirtuins and poly(adenosine diphosphate-ribose) polymerases. Cellular NAD(+) concentrations change during aging, and modulation of NAD(+) usage or production can prolong both health span and life span. Here we review factors that regulate NAD(+) and discuss how supplementation with NAD(+) precursors may represent a new therapeutic opportunity for aging and its associated disorders, particularly neurodegenerative diseases.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Objects Annotated

Genes (Rattus norvegicus)
Sirt1  (sirtuin 1)
Sirt2  (sirtuin 2)
Sirt3  (sirtuin 3)
Sirt4  (sirtuin 4)
Sirt5  (sirtuin 5)
Sirt6  (sirtuin 6)
Sirt7  (sirtuin 7)

Genes (Mus musculus)
Sirt1  (sirtuin 1)
Sirt2  (sirtuin 2)
Sirt3  (sirtuin 3)
Sirt4  (sirtuin 4)
Sirt5  (sirtuin 5)
Sirt6  (sirtuin 6)
Sirt7  (sirtuin 7)

Genes (Homo sapiens)
SIRT1  (sirtuin 1)
SIRT2  (sirtuin 2)
SIRT3  (sirtuin 3)
SIRT4  (sirtuin 4)
SIRT5  (sirtuin 5)
SIRT6  (sirtuin 6)
SIRT7  (sirtuin 7)


Additional Information