Ptk6 (protein tyrosine kinase 6) - Rat Genome Database

Name: Ptk6
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ptk6 (protein tyrosine kinase 6) Rattus norvegicus

Analyze

Symbol:

Ptk6

Name:

protein tyrosine kinase 6

RGD ID:

1309098

Description:

Predicted to enable identical protein binding activity; non-membrane spanning protein tyrosine kinase activity; and signaling receptor binding activity. Predicted to be involved in several processes, including cellular response to retinoic acid; negative regulation of protein tyrosine kinase activity; and protein phosphorylation. Predicted to be located in several cellular components, including cytosol; nuclear body; and ruffle. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Orthologous to human PTK6 (protein tyrosine kinase 6); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; furan.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC366275; protein-tyrosine kinase 6; PTK6 protein tyrosine kinase 6

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PTK6 (protein tyrosine kinase 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Ptk6 (PTK6 protein tyrosine kinase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Ptk6 (protein tyrosine kinase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PTK6 (protein tyrosine kinase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC102156300 (collagen alpha-4(IV) chain)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ptk6 (protein tyrosine kinase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PTK6 (protein tyrosine kinase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PTK6 (protein tyrosine kinase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ptk6 (protein tyrosine kinase 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	PTK6 (protein tyrosine kinase 6)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Ptk6 (PTK6 protein tyrosine kinase 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ptk6b (PTK6 protein tyrosine kinase 6b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	ptk6a (PTK6 protein tyrosine kinase 6a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	168,307,073 - 168,315,664 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	168,307,073 - 168,315,664 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	172,687,773 - 172,696,476 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	181,646,876 - 181,655,579 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	178,308,025 - 178,316,616 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	176,698,305 - 176,706,896 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	176,698,305 - 176,706,896 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	180,408,336 - 180,417,078 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	170,336,505 - 170,345,096 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	170,242,877 - 170,251,132 (-)	NCBI
Celera	3	164,270,220 - 164,278,811 (+)	NCBI		Celera
Cytogenetic Map	3	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant nocturnal frontal lobe epilepsy (ISO)

autosomal recessive dyskeratosis congenita 5 (ISO)

benign familial infantile seizures 6 (ISO)

developmental and epileptic encephalopathy (ISO)

developmental and epileptic encephalopathy 33 (ISO)

early infantile epileptic encephalopathy (ISO)

genetic disease (ISO)

keratoconus (ISO)

neuronal ceroid lipofuscinosis (ISO)

Pulmonary Fibrosis and/or Bone Marrow Failure Syndrome, Telomere-Related, 3 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

Aflatoxin B2 alpha (ISO)

antirheumatic drug (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

diarsenic trioxide (ISO)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

indole-3-methanol (EXP)

lipopolysaccharide (ISO)

N-acetyl-L-cysteine (EXP)

N-nitrosodiethylamine (EXP)

paclitaxel (ISO)

paracetamol (EXP)

phenformin (EXP)

ponatinib (ISO)

rac-lactic acid (ISO)

rotenone (EXP,ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium fluoride (ISO)

sotorasib (ISO)

tamoxifen (ISO)

thioacetamide (EXP)

trametinib (ISO)

trichloroethene (EXP)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

vanadium atom (ISO)

vanadium(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell differentiation (IBA)

cell migration (ISO)

cellular response to retinoic acid (ISO)

innate immune response (IBA)

intestinal epithelial cell differentiation (ISO)

negative regulation of growth (ISO)

negative regulation of protein tyrosine kinase activity (ISO)

positive regulation of neuron projection development (ISO)

protein autophosphorylation (ISO)

transmembrane receptor protein tyrosine kinase signaling pathway (IBA)

tyrosine phosphorylation of STAT protein (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (IEA,ISO)

extrinsic component of cytoplasmic side of plasma membrane (IBA)

nuclear body (IEA,ISO)

nucleoplasm (ISO)

nucleus (ISO)

plasma membrane (ISO)

ruffle (ISO)

Molecular Function

ATP binding (IEA)

identical protein binding (ISO)

non-membrane spanning protein tyrosine kinase activity (IBA,ISO)

protein binding (ISO)

protein tyrosine kinase activity (ISO)

signaling receptor binding (IBA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:10913193	PMID:12121988	PMID:12200423	PMID:12833144	PMID:15056653	PMID:15539407	PMID:15572663	PMID:16082217	PMID:16179349	PMID:16568091	PMID:16782882	PMID:17910947
PMID:17997837	PMID:18719096	PMID:18829532	PMID:19393627	PMID:19401189	PMID:20554524	PMID:20606012	PMID:22084245	PMID:25733683	PMID:26751287

Genomics

Comparative Map Data

Ptk6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	3	168,307,073 - 168,315,664 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	168,307,073 - 168,315,664 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	172,687,773 - 172,696,476 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	3	181,646,876 - 181,655,579 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	3	178,308,025 - 178,316,616 (-)	NCBI	Rnor_WKY
Rnor_6.0	3	176,698,305 - 176,706,896 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	176,698,305 - 176,706,896 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	180,408,336 - 180,417,078 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	170,336,505 - 170,345,096 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	170,242,877 - 170,251,132 (-)	NCBI
Celera	3	164,270,220 - 164,278,811 (+)	NCBI		Celera
Cytogenetic Map	3	q43	NCBI

PTK6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	20	63,528,001 - 63,537,376 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	20	63,528,001 - 63,537,376 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	20	62,159,354 - 62,168,729 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	20	61,630,210 - 61,639,151 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	20	61,630,221 - 61,639,151	NCBI
Celera	20	58,840,123 - 58,849,063 (-)	NCBI		Celera
Cytogenetic Map	20	q13.33	NCBI
HuRef	20	58,889,971 - 58,898,928 (-)	NCBI		HuRef
CHM1_1	20	62,060,892 - 62,069,731 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	20	65,340,691 - 65,349,973 (-)	NCBI		T2T-CHM13v2.0

Ptk6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	180,836,917 - 180,845,408 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	180,835,514 - 180,844,582 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	181,195,124 - 181,202,789 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	181,193,721 - 181,202,789 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	180,929,829 - 180,937,494 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	181,124,531 - 181,132,196 (-)	NCBI		MGSCv36	mm8
Celera	2	185,277,943 - 185,285,608 (-)	NCBI		Celera
Cytogenetic Map	2	H4	NCBI
cM Map	2	103.62	NCBI

Ptk6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955528	687,996 - 695,596 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955528	687,996 - 695,596 (+)	NCBI	ChiLan1.0	ChiLan1.0

PTK6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	20	69,318,926 - 69,330,595 (-)	NCBI		NHGRI_mPanPan1
PanPan1.1	20	61,453,386 - 61,462,951 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	20	61,453,386 - 61,462,951 (-)	Ensembl	panpan1.1		panPan2

LOC102156300
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	24	47,124,847 - 47,132,516 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	24	46,324,188 - 46,330,708 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	24	48,094,349 - 48,100,872 (-)	NCBI		ROS_Cfam_1.0
UNSW_CanFamBas_1.0	24	47,234,634 - 47,241,155 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	24	47,972,659 - 47,979,186 (-)	NCBI		UU_Cfam_GSD_1.0

Ptk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	195,371,493 - 195,380,130 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936514	10,826,724 - 10,832,954 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936514	10,826,013 - 10,833,170 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PTK6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	17	62,538,855 - 62,546,870 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	17	62,538,853 - 62,547,866 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

PTK6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	667,440 - 676,380 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	667,510 - 676,109 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666050	48,225,911 - 48,235,200 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ptk6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624741	29,185,300 - 29,191,863 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624741	29,183,992 - 29,192,091 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ptk6
41 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	81
Count of miRNA genes:	60
Interacting mature miRNAs:	75
Transcripts:	ENSRNOT00000017337
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1559282	Emca5	Estrogen-induced mammary cancer QTL 5	3.9		mammary gland integrity trait (VT:0010552)	percentage of study population developing mammary tumors during a period of time (CMO:0000948)	3	43827364	169034231	Rat
631541	Bp81	Blood pressure QTL 81	4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	124122556	169034231	Rat
1578656	Vnigr2	Vascular neointimal growth QTL 2	4.2		artery morphology trait (VT:0002191)	lesioned artery residual lumen area (CMO:0001417)	3	130656562	169034231	Rat
1578653	Vnigr3	Vascular neointimal growth QTL 3	3.1		artery morphology trait (VT:0002191)	artery neointimal hyperplastic lesion area (CMO:0001414)	3	130656562	169034231	Rat
9589106	Insul23	Insulin level QTL 23	13.86	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	3	131635904	169034231	Rat
2298477	Eau4	Experimental allergic uveoretinitis QTL 4		0.0011	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	3	137398739	169034231	Rat
8552952	Pigfal13	Plasma insulin-like growth factor 1 level QTL 13			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	3	138799500	169034231	Rat
1298068	Bp167	Blood pressure QTL 167		0.004	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	141074471	169034231	Rat
2317883	Alcrsp26	Alcohol response QTL 26	1.8	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	3	145526770	169034231	Rat
8552791	Vie2	Viral induced encephalitis QTL 2	4.1		brain integrity trait (VT:0010579)	encephalitis incidence/prevalence measurement (CMO:0002361)	3	145956084	169034231	Rat
1300161	Rf10	Renal function QTL 10	3.57		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	3	161192952	169034231	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1		1	1		1
Low	2		20	20		20						1
Below cutoff		9	19	8	15	8	2	2	14	17	5	10	2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001108968	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117053	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000123	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000017337 ⟹ ENSRNOP00000017337

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	168,307,073 - 168,315,664 (-)	Ensembl
Rnor_6.0 Ensembl	3	176,698,305 - 176,706,896 (-)	Ensembl

RefSeq Acc Id:

NM_001108968 ⟹ NP_001102438

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	3	168,307,073 - 168,315,664 (-)	NCBI
Rnor_6.0	3	176,698,305 - 176,706,896 (-)	NCBI
Rnor_5.0	3	180,408,336 - 180,417,078 (-)	NCBI
RGSC_v3.4	3	170,336,505 - 170,345,096 (-)	RGD
Celera	3	164,270,220 - 164,278,811 (+)	RGD

Sequence:

show sequence

TCTGTGTAACTGTGGCTAGGTCTTGTCAAGGGGTTGTTTAGCTGACAGGCTTTCACCGAGTGTG
AACACATAGCATGGTCTTATCCTGTAGATAAAAGAACAAACAGGGGCTAGAAGGGCCTTCAGGG
TGGAGCTAGGTTAGTCCATCTCCAATCAGTGCCGGGTGTGGCTGCTCTCCTGCCCATCATAAGG
AAGTAGGTGTGACTGGCTTTCTGGGAAAAGTTCCTCCTACCTCTCCCAGCAGTAAGTGTCTACA
AGTAGGCCACAGTTGGCTCTGCCACTAAGCCTGCCATGGTGTCTTTGGACAAGGCTCACCTGGG
TCCTAAGTATGTGGGCCTCTGGGACTTCAAAGCACGAACGGACGAGGAGCTGAGCTTTCAGGCA
GGAGACCTCCTCCATGTTACCAGGAAGGAGGAACAGTGGTGGTGGGCCACCCTGCTGGATGCGG
AAGGCAAGGCCTTGGCTGAGGGCTACGTGCCCCACAACTACCTGGCTGAGAAGGAAACTGTGGA
GTCTGAACCGTGGTTCTTTGGTTGCATCTCCCGCTCAGAGGCCATGCACAGGCTGCAGTCTGAG
GACTACCCGAAGGGTACCTTCCTGATCAGAGTCAGCCAGAAGCCAGGAGCAGACTATGTCCTCT
CCGTGTGGGATGCTGAGGCTGTTCGACATTACAGGATCTGGAGGAACAGTGCGGGCAGGCTGCA
CCTGAATGAGGTGGTATCCTTCTCCAGTCTGTCTGAGCTTGTGAACTACCACAAGACCCACAAC
CTGTCCCCTGGCCTACAGCTCTCCATGGCCTGCTGGAAGCTCAAAACTGAGCCCTTGCCCCACT
GGGATGACTGGGAGAGGCCGAGGGAGGAGTTCACGCTCTGTAAGAAGCTGGGGTCTGGCTACTT
TGGGGAGGTCTTTGAAGGGCTCTGGAAAGGCCTGGTCCGTGTGGCTGTGAAGGTGATCTCTAGA
GACAATCTCCTGCACCAGCACACCTTCCAGGCTGAGATTCAAGCCATGAAGAAGCTGCGACACA
AGCACATCCTGTCGCTGTACGCTGTGGCAACTGCAGGGGACCCAGTCTATATCATCACGGAGCT
CATGCCCAAGGGGAGCCTGCTGCAGCTATTGCGGGACTCGGATGAGAAAGACCTGCCTATTTTG
GAACTGGTGGACTTTGCATCACAGGTTGCCGAGGGCATGTGCTACCTGGAATCTCAGAATTACA
TTCACCGTGACCTGGCTGCAAGGAACGTTCTCGTTACTGAGAACAATCTCTGCAAAGTGGGGGA
CTTTGGGCTGGCCAGGCTCGTCAAGGAGGACATCTACCTTTCCCGTGACCACAACGTCCCCTAC
AAATGGACAGCACCTGAGGCACTTTCCCGAGGGCATTACTCCATCAAATCGGATGTCTGGTCTT
TTGGTGTTCTCCTTCATGAAATTTTCAGCAGGGGGCAGATGCCCTACCCAGGCATGTCCAATCA
CGAAACCTTCCTGAGGGTGGATGCCGGCTACCGCATGCCCTGCCCCTTGGAGTGCCCACCCAAC
ATACACAAGCTGATGCTTAGCTGTTGGAGCAGAGACCCTAAGCAGAGACCCTGCTTCAAAGACC
TGTGTGAGAAACTCTCAGGTATCACTAGGTATGAGAACCTGGTCTGAGCTCCTCGGCTGTGGCC
AGGACCCACAGAAGAGGGCCTCGTGGTTATCCTGGATTTCTACCGAAGGCATGCACCACCCTTC
AGTTTACTGAGAAGAAGGGGTAGGGAACACACCAAACATATCTTAAACACTGAGTGTGGTCAAG
GAAAGAAAGAGGCAGCAGCCATGTTCCTTTCCCATTTATCCTCCTCCAGGAGGCAGTACACAAA
ATCCAGGAAGTCACTCTCTGGCTTCCTCATCCCTTCTCGCAAGACTTCATGTGACGGAGAAGCC
AAGAAGAGTCTAGGCAATAGTCTTTGTGGAATTCTTGCCATATCACTTTTAGAGCTTGACTGCC
CACAAACACATAGCCCACCCATTAGTGCCTTAATTCTGCAGGATCTTATGCCACGTAAAACTCA
GAAGAAGTTTGCATGATTTTCTCTTTATAACCTTGGCTTCGCTGGAGGAGTCTCGCCTAGGAAG
CTCAAGACAGATAAAATGATATGAAATTTC

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Protein Sequences


Protein RefSeqs	NP_001102438	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL88742	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001102438 ⟸ NM_001108968

- UniProtKB:

D3ZDS3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVSLDKAHLGPKYVGLWDFKARTDEELSFQAGDLLHVTRKEEQWWWATLLDAEGKALAEGYVPH
NYLAEKETVESEPWFFGCISRSEAMHRLQSEDYPKGTFLIRVSQKPGADYVLSVWDAEAVRHYR
IWRNSAGRLHLNEVVSFSSLSELVNYHKTHNLSPGLQLSMACWKLKTEPLPHWDDWERPREEFT
LCKKLGSGYFGEVFEGLWKGLVRVAVKVISRDNLLHQHTFQAEIQAMKKLRHKHILSLYAVATA
GDPVYIITELMPKGSLLQLLRDSDEKDLPILELVDFASQVAEGMCYLESQNYIHRDLAARNVLV
TENNLCKVGDFGLARLVKEDIYLSRDHNVPYKWTAPEALSRGHYSIKSDVWSFGVLLHEIFSRG
QMPYPGMSNHETFLRVDAGYRMPCPLECPPNIHKLMLSCWSRDPKQRPCFKDLCEKLSGITRYE
NLV

hide sequence

RefSeq Acc Id:

ENSRNOP00000017337 ⟸ ENSRNOT00000017337

Protein Domains

Protein kinase SH2 SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-D3ZDS3-F1-model_v2	AlphaFold	D3ZDS3	1-451	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1309098	AgrOrtholog
BioCyc Gene	G2FUF-46302	BioCyc
Ensembl Genes	ENSRNOG00000012987	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000017337	ENTREZGENE
	ENSRNOP00000017337.4	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017337	ENTREZGENE
	ENSRNOT00000017337.5	UniProtKB/TrEMBL
Gene3D-CATH	3.30.505.10	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	PTK6_SH2	UniProtKB/TrEMBL
	Ser-Thr/Tyr-Pkinase	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH2_dom_sf	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Tyr_Pkinase_cat_dom	UniProtKB/TrEMBL
	Tyr_prot_kinase_AS	UniProtKB/TrEMBL
KEGG Report	rno:366275	UniProtKB/TrEMBL
NCBI Gene	366275	ENTREZGENE
PANTHER	PROTEIN-TYROSINE KINASE 6	UniProtKB/TrEMBL
	TYROSINE-PROTEIN KINASE	UniProtKB/TrEMBL
Pfam	Pkinase_Tyr	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PhenoGen	Ptk6	PhenoGen
PRINTS	SH2DOMAIN	UniProtKB/TrEMBL
	SH3DOMAIN	UniProtKB/TrEMBL
	TYRKINASE	UniProtKB/TrEMBL
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_TYR	UniProtKB/TrEMBL
	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
SMART	SH2	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	TyrKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
	SSF55550	UniProtKB/TrEMBL
UniProt	D3ZDS3	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-02-28	Ptk6	protein tyrosine kinase 6	Ptk6	PTK6 protein tyrosine kinase 6	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-04-30	Ptk6	PTK6 protein tyrosine kinase 6	Ptk6_predicted	PTK6 protein tyrosine kinase 6 (predicted)	'predicted' is removed	2292626	APPROVED
2005-01-12	Ptk6_predicted	PTK6 protein tyrosine kinase 6 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar