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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2922
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Irs1
Name: insulin receptor substrate 1
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDMetformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]

PMID:27634381
multiple interactionsISORGD:108166480464CTDMetformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]

PMID:23927877
multiple interactionsISORGD:7334736480464CTDMetformin affects the reaction [Testosterone results in decreased expression of IRS1], Metformin inhibits the reaction [INS protein results in decreased expression of IRS1 protein], Metformin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]

PMID:19328476, PMID:30914352, PMID:30928401
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.