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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3738
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sp1
Name: Sp1 transcription factor
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Sp1decreases expressionISOSP1 (Homo sapiens)6480464CTDMetformin results in decreased expression of SP1 proteinPMID:25110054 PMID:26317792
Sp1multiple interactionsISOSP1 (Homo sapiens)6480464CTDMetformin inhibits the reaction [SP1 protein results in increased expression of AHR protein]PMID:25110054
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