Aars1 (alanyl-tRNA synthetase 1) - Rat Genome Database

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Gene: Aars1 (alanyl-tRNA synthetase 1) Rattus norvegicus
Analyze
Symbol: Aars1
Name: alanyl-tRNA synthetase 1
RGD ID: 1304832
Description: Exhibits alanine-tRNA ligase activity; anion binding activity; and tRNA binding activity. Involved in alanyl-tRNA aminoacylation. Localizes to cytoplasm. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2N and developmental and epileptic encephalopathy 29. Orthologous to human AARS1 (alanyl-tRNA synthetase 1); PARTICIPATES IN alanine metabolic pathway; lactic acidosis pathway; primary hyperoxaluria type 1 pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Aars; alanine--tRNA ligase; alanine--tRNA ligase, cytoplasmic; alanyl-tRNA synthetase; alanyl-tRNA synthetase, cytoplasmic; alaRS; LOC292023
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21938,999,130 - 39,021,152 (+)NCBI
Rnor_6.0 Ensembl1943,193,257 - 43,215,281 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01943,193,264 - 43,215,281 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01954,018,025 - 54,040,573 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41940,952,408 - 40,974,425 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11940,957,348 - 40,979,299 (+)NCBI
Celera1938,390,301 - 38,412,318 (+)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-butoxyethanol  (ISO)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
aflatoxin B1  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chloroacetaldehyde  (ISO)
chloropicrin  (ISO)
cidofovir anhydrous  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
coumestrol  (ISO)
curcumin  (ISO)
cyclosporin A  (EXP,ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
disulfiram  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
graphite  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (EXP)
metformin  (EXP)
methylparaben  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-ethyl-N-nitrosourea  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
ochratoxin A  (ISO)
paracetamol  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
prostaglandin A1  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
T-2 toxin  (EXP)
thapsigargin  (ISO)
titanium dioxide  (ISO)
tolcapone  (EXP)
trimellitic anhydride  (ISO)
tungsten  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
mitochondrion  (IBA)

Molecular Function

References

Additional References at PubMed
PMID:12477932   PMID:16906134   PMID:19946888   PMID:20010690   PMID:20458337   PMID:25422440   PMID:27622773   PMID:28493438   PMID:29769718  


Genomics

Candidate Gene Status
Aars1 is a candidate Gene for QTL Eau8
Comparative Map Data
Aars1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21938,999,130 - 39,021,152 (+)NCBI
Rnor_6.0 Ensembl1943,193,257 - 43,215,281 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01943,193,264 - 43,215,281 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01954,018,025 - 54,040,573 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41940,952,408 - 40,974,425 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11940,957,348 - 40,979,299 (+)NCBI
Celera1938,390,301 - 38,412,318 (+)NCBICelera
Cytogenetic Map19q12NCBI
AARS1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1670,251,983 - 70,289,707 (-)EnsemblGRCh38hg38GRCh38
GRCh381670,252,295 - 70,289,509 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371670,286,201 - 70,323,409 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361668,843,798 - 68,880,913 (-)NCBINCBI36hg18NCBI36
Build 341668,843,797 - 68,880,913NCBI
Celera1655,204,771 - 55,241,876 (+)NCBI
Cytogenetic Map16q22.1NCBI
HuRef1656,119,458 - 56,156,083 (-)NCBIHuRef
CHM1_11671,693,759 - 71,730,869 (-)NCBICHM1_1
Aars
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398111,759,781 - 111,784,237 (+)NCBIGRCm39mm39
GRCm39 Ensembl8111,759,776 - 111,784,296 (+)Ensembl
GRCm388111,027,778 - 111,055,569 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8111,033,144 - 111,057,664 (+)EnsemblGRCm38mm10GRCm38
MGSCv378113,557,867 - 113,580,770 (+)NCBIGRCm37mm9NCBIm37
MGSCv368113,920,642 - 113,943,545 (+)NCBImm8
Celera8115,257,943 - 115,280,837 (+)NCBICelera
Cytogenetic Map8E1NCBI
Aars1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554843,089,235 - 3,115,230 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554843,090,678 - 3,115,224 (-)NCBIChiLan1.0ChiLan1.0
AARS1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11670,086,735 - 70,121,902 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1670,086,735 - 70,121,902 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01654,727,601 - 54,763,458 (+)NCBIMhudiblu_PPA_v0panPan3
AARS1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1576,288,780 - 76,343,262 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl576,288,782 - 76,343,207 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha576,250,625 - 76,276,397 (-)NCBI
ROS_Cfam_1.0576,725,260 - 76,750,984 (-)NCBI
UMICH_Zoey_3.1576,547,302 - 76,573,204 (-)NCBI
UNSW_CanFamBas_1.0576,370,741 - 76,396,505 (-)NCBI
UU_Cfam_GSD_1.0576,862,531 - 76,888,314 (-)NCBI
Aars1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934936,294,883 - 36,320,498 (-)NCBI
SpeTri2.0NW_00493647523,268,613 - 23,294,236 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AARS1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl613,298,348 - 13,321,364 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1613,298,336 - 13,321,423 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2613,363,115 - 13,385,168 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AARS1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1553,399,717 - 53,433,472 (-)NCBI
ChlSab1.1 Ensembl553,395,638 - 53,433,461 (-)Ensembl
Vero_WHO_p1.0NW_02366604716,186,832 - 16,220,663 (-)NCBI
Aars1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474612,540,969 - 12,566,989 (-)NCBI

Position Markers
RH126058  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21939,020,870 - 39,021,067 (-)MAPPER
Rnor_6.01943,193,344 - 43,193,540NCBIRnor6.0
Rnor_5.01954,018,107 - 54,018,303UniSTSRnor5.0
RGSC_v3.41940,974,149 - 40,974,345UniSTSRGSC3.4
Celera1938,412,042 - 38,412,238UniSTS
Cytogenetic Map19q12UniSTS
AI316495  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21939,020,648 - 39,020,794 (-)MAPPER
Rnor_6.01943,193,617 - 43,193,762NCBIRnor6.0
Rnor_5.01954,018,380 - 54,018,525UniSTSRnor5.0
RGSC_v3.41940,973,927 - 40,974,072UniSTSRGSC3.4
Celera1938,411,820 - 38,411,965UniSTS
Cytogenetic Map19q12UniSTS
RH137129  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21939,020,826 - 39,021,012 (-)MAPPER
Rnor_6.01943,193,399 - 43,193,584NCBIRnor6.0
Rnor_5.01954,018,162 - 54,018,347UniSTSRnor5.0
RGSC_v3.41940,974,105 - 40,974,290UniSTSRGSC3.4
Celera1938,411,998 - 38,412,183UniSTS
Cytogenetic Map19q12UniSTS
RH66606  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21939,015,663 - 39,016,271 (-)MAPPER
Rnor_6.01943,198,140 - 43,198,747NCBIRnor6.0
Rnor_5.01954,022,903 - 54,023,510UniSTSRnor5.0
RGSC_v3.41940,968,942 - 40,969,549UniSTSRGSC3.4
Celera1938,406,835 - 38,407,442UniSTS
Cytogenetic Map19q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317848Alcrsp21Alcohol response QTL 211.8999999761581420.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)19104464846044648Rat
61447Tcas1Tongue tumor susceptibility QTL 16.08tongue integrity trait (VT:0010553)squamous cell carcinoma of the tongue maximum tumor diameter (CMO:0001875)19195770746957707Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19243296347217667Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19243296362275575Rat
9589102Slep13Serum leptin concentration QTL 134.630.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)19370183548701835Rat
8694186Bw152Body weight QTL 1523.340.001body mass (VT:0001259)body weight gain (CMO:0000420)19370183548701835Rat
724565Tcas5Tongue tumor susceptibility QTL 510.04tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)19500757143907843Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19650676160220581Rat
724518Uae19Urinary albumin excretion QTL 195.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19807254547318201Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191130392747879277Rat
1331788Rf45Renal function QTL 452.818kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)191702800352538299Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191899398262275575Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191917749562275575Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)192140778762275575Rat
1549835Tcas7Tongue tumor susceptibility QTL 70.001tongue integrity trait (VT:0010553)squamous cell carcinoma of the head and neck tumor number (CMO:0001876)192445572643907843Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192481825762275575Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)193299439262275575Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193791679960220451Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193791679960220451Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:262
Count of miRNA genes:173
Interacting mature miRNAs:200
Transcripts:ENSRNOT00000025052
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025052   ⟹   ENSRNOP00000025051
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1943,193,264 - 43,215,281 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000082151   ⟹   ENSRNOP00000075266
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1943,193,257 - 43,215,077 (-)Ensembl
RefSeq Acc Id: NM_001100517   ⟹   NP_001093987
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21938,999,130 - 39,021,147 (+)NCBI
Rnor_6.01943,193,264 - 43,215,281 (-)NCBI
Rnor_5.01954,018,025 - 54,040,573 (-)NCBI
RGSC_v3.41940,952,408 - 40,974,425 (+)RGD
Celera1938,390,301 - 38,412,318 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255580   ⟹   XP_006255642
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01943,193,264 - 43,215,208 (-)NCBI
Rnor_5.01954,018,025 - 54,040,573 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255581   ⟹   XP_006255643
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21938,999,168 - 39,021,152 (+)NCBI
Rnor_6.01943,193,264 - 43,215,246 (-)NCBI
Rnor_5.01954,018,025 - 54,040,573 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255582   ⟹   XP_006255644
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21938,999,203 - 39,021,152 (+)NCBI
Rnor_6.01943,193,264 - 43,215,208 (-)NCBI
Rnor_5.01954,018,025 - 54,040,573 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255583   ⟹   XP_006255645
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21938,999,161 - 39,021,152 (+)NCBI
Rnor_6.01943,193,264 - 43,215,227 (-)NCBI
Rnor_5.01954,018,025 - 54,040,573 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097632   ⟹   XP_038953560
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21938,999,168 - 39,021,152 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_001093987   ⟸   NM_001100517
- UniProtKB: P50475 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255643   ⟸   XM_006255581
- Peptide Label: isoform X1
- UniProtKB: P50475 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255645   ⟸   XM_006255583
- Peptide Label: isoform X1
- UniProtKB: P50475 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255644   ⟸   XM_006255582
- Peptide Label: isoform X1
- UniProtKB: P50475 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255642   ⟸   XM_006255580
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000075266   ⟸   ENSRNOT00000082151
RefSeq Acc Id: ENSRNOP00000025051   ⟸   ENSRNOT00000025052
RefSeq Acc Id: XP_038953560   ⟸   XM_039097632
- Peptide Label: isoform X1

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701140
Promoter ID:EPDNEW_R11664
Type:initiation region
Name:Aars_1
Description:alanyl-tRNA synthetase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01943,215,208 - 43,215,268EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1304832 AgrOrtholog
Ensembl Genes ENSRNOG00000018404 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000025051 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000075266 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025052 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000082151 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7385432 IMAGE-MGC_LOAD
InterPro Ala-tRNA-lgiase_IIc UniProtKB/Swiss-Prot
  Ala-tRNA-ligase_IIc_anticod-bd UniProtKB/Swiss-Prot
  Ala-tRNA-synth_IIc_core UniProtKB/Swiss-Prot
  Ala-tRNA-synth_IIc_N UniProtKB/Swiss-Prot
  Ala_tRNA_ligase_euk/bac UniProtKB/Swiss-Prot
  DHHA1_dom UniProtKB/Swiss-Prot
  Thr/Ala-tRNA-synth_IIc_edit UniProtKB/Swiss-Prot
  Transl_B-barrel_sf UniProtKB/Swiss-Prot
  tRNA_SAD UniProtKB/Swiss-Prot
KEGG Report rno:292023 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112731 IMAGE-MGC_LOAD
NCBI Gene 292023 ENTREZGENE
Pfam DHHA1 UniProtKB/Swiss-Prot
  tRNA-synt_2c UniProtKB/Swiss-Prot
  tRNA_SAD UniProtKB/Swiss-Prot
PhenoGen Aars1 PhenoGen
PRINTS TRNASYNTHALA UniProtKB/Swiss-Prot
PROSITE AA_TRNA_LIGASE_II_ALA UniProtKB/Swiss-Prot
SMART tRNA_SAD UniProtKB/Swiss-Prot
Superfamily-SCOP SSF101353 UniProtKB/Swiss-Prot
  SSF50447 UniProtKB/Swiss-Prot
  SSF55186 UniProtKB/Swiss-Prot
TIGRFAMs alaS UniProtKB/Swiss-Prot
UniProt P50475 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A6IZ80 UniProtKB/Swiss-Prot
  Q4G057 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-08-13 Aars1  alanyl-tRNA synthetase 1  Aars  alanyl-tRNA synthetase  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Aars  alanyl-tRNA synthetase  Aars_predicted  alanyl-tRNA synthetase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Aars_predicted  alanyl-tRNA synthetase (predicted)      Symbol and Name status set to approved 70820 APPROVED