Tlr5 (toll-like receptor 5) - Rat Genome Database

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Gene: Tlr5 (toll-like receptor 5) Rattus norvegicus
Analyze
Symbol: Tlr5
Name: toll-like receptor 5
RGD ID: 631351
Description: Predicted to enable interleukin-1 receptor binding activity and pattern recognition receptor activity. Involved in cellular response to lipopolysaccharide; male gonad development; and positive regulation of nitric oxide biosynthetic process. Predicted to be active in plasma membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5); PARTICIPATES IN Toll-like receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81397,166,430 - 97,190,642 (+)NCBIGRCr8
mRatBN7.21394,634,778 - 94,658,992 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,634,801 - 94,657,738 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1397,156,784 - 97,161,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,556,697 - 98,560,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01395,738,872 - 95,743,126 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,364,784 - 101,385,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,381,510 - 101,385,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013106,294,254 - 106,315,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41399,025,501 - 99,029,755 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11399,217,286 - 99,217,523 (+)NCBI
Celera1394,180,743 - 94,184,997 (+)NCBICelera
Cytogenetic Map13q26NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5. Assassi S, etal., J Rheumatol. 2011 Jan;38(1):87-98. doi: 10.3899/jrheum.100469. Epub 2010 Oct 15.
2. In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain. Bambou JC, etal., J Biol Chem 2004 Oct 8;279(41):42984-92. Epub 2004 Aug 9.
3. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
4. Identification of Toll-like receptors in the rat (Rattus norvegicus): messenger RNA expression in the male reproductive tract under conditions of androgen variation. Biswas B, etal., Am J Reprod Immunol. 2009 Oct;62(4):243-52. Epub 2009 Aug 24.
5. TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis. Blohmke CJ, etal., J Immunol. 2010 Dec 15;185(12):7731-8. Epub 2010 Nov 10.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
8. Dysregulation of innate immune receptors on neutrophils in chronic granulomatous disease. Hartl D, etal., J Allergy Clin Immunol. 2008 Feb;121(2):375-382.e9. Epub 2007 Dec 26.
9. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. Hawn TR, etal., J Exp Med. 2003 Nov 17;198(10):1563-72.
10. Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila. Hawn TR, etal., J Immunol. 2007 Nov 15;179(10):6981-7.
11. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. Hawn TR, etal., PLoS One. 2009 Jun 22;4(6):e5990. doi: 10.1371/journal.pone.0005990.
12. Toll-like receptors and their adaptors are regulated in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles. Hirayama T, etal., J Orthop Res. 2011 Feb 9. doi: 10.1002/jor.21369.
13. Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue. Kauppila JH, etal., Br J Cancer. 2013 Feb 19;108(3):638-43. doi: 10.1038/bjc.2012.589. Epub 2013 Jan 3.
14. TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease. Koller B, etal., J Immunol. 2008 Aug 15;181(4):2753-63.
15. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
16. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia. Morris AE, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1112-9. Epub 2009 Oct 2.
19. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
20. Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage. Oshikawa K and Sugiyama Y, Biochem Biophys Res Commun. 2003 Jun 6;305(3):649-55.
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. Effects of mannoprotein E1 in liquid diet on inflammatory response and TLR5 expression in the gut of rats infected by Salmonella typhimurium. Posadas SJ, etal., BMC Gastroenterol. 2010 Jun 8;10:58.
23. GOA pipeline RGD automated data pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Comprehensive gene review and curation RGD comprehensive gene curation
27. Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction. Rolli J, etal., PLoS One. 2010 Sep 13;5(9):e12687.
28. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Siezen CL, etal., Pediatr Infect Dis J. 2009 Apr;28(4):333-5.
29. Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). Wiersinga WJ, etal., PLoS Med. 2007 Jul 31;4(7):e248.
30. Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide. Yu FS, etal., J Immunol. 2010 Jul 15;185(2):1142-9. Epub 2010 Jun 21.
31. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Zhou R, etal., Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.
Additional References at PubMed
PMID:12925853   PMID:15788393   PMID:17128265   PMID:18592153   PMID:19593445   PMID:21985371   PMID:24091496   PMID:27760316   PMID:28685867   PMID:33042267   PMID:33673008   PMID:34898357  


Genomics

Comparative Map Data
Tlr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81397,166,430 - 97,190,642 (+)NCBIGRCr8
mRatBN7.21394,634,778 - 94,658,992 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,634,801 - 94,657,738 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1397,156,784 - 97,161,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,556,697 - 98,560,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01395,738,872 - 95,743,126 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,364,784 - 101,385,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,381,510 - 101,385,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013106,294,254 - 106,315,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41399,025,501 - 99,029,755 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11399,217,286 - 99,217,523 (+)NCBI
Celera1394,180,743 - 94,184,997 (+)NCBICelera
Cytogenetic Map13q26NCBI
TLR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381223,109,404 - 223,143,248 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1223,109,404 - 223,143,292 (-)EnsemblGRCh38hg38GRCh38
GRCh371223,282,746 - 223,316,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,350,207 - 221,383,247 (-)NCBINCBI36Build 36hg18NCBI36
Celera1196,502,104 - 196,535,977 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1193,957,238 - 193,991,230 (-)NCBIHuRef
CHM1_11224,555,804 - 224,589,771 (-)NCBICHM1_1
T2T-CHM13v2.01222,347,318 - 222,381,267 (-)NCBIT2T-CHM13v2.0
Tlr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,782,317 - 182,804,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,782,353 - 182,804,010 (+)EnsemblGRCm39 Ensembl
GRCm381182,954,752 - 182,976,044 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,954,788 - 182,976,044 (+)EnsemblGRCm38mm10GRCm38
MGSCv371184,884,919 - 184,906,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,884,919 - 184,906,170 (+)NCBIMGSCv36mm8
Celera1189,998,902 - 190,020,262 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map186.12NCBI
Tlr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,556,523 - 1,559,093 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBIChiLan1.0ChiLan1.0
TLR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2126,171,713 - 26,204,781 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1126,127,751 - 26,160,814 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01198,787,046 - 198,819,537 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11203,797,720 - 203,831,605 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1203,798,767 - 203,801,343 (-)Ensemblpanpan1.1panPan2
TLR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13823,700,323 - 23,705,628 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3823,702,033 - 23,705,314 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3823,729,352 - 23,731,928 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03823,873,004 - 23,878,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3823,874,719 - 23,878,000 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13823,620,126 - 23,622,702 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03824,170,412 - 24,172,988 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03824,572,699 - 24,575,275 (+)NCBIUU_Cfam_GSD_1.0
Tlr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934454,334,832 - 54,363,906 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936526383,418 - 401,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936526383,490 - 387,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1019,387,666 - 19,410,024 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11019,387,666 - 19,410,024 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21021,886,309 - 21,888,880 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,418,895 - 6,440,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,437,638 - 6,440,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660556,652,060 - 6,685,032 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248355,500,461 - 5,503,034 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248355,495,723 - 5,503,462 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tlr5
214 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:343
Count of miRNA genes:193
Interacting mature miRNAs:220
Transcripts:ENSRNOT00000004821
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1320605871101339738Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137402391897213863Rat
1641901Alcrsp6Alcohol response QTL 6response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)135236217197362171Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1365103704106807694Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1365103704106807694Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1361825626106807694Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1330395351101056920Rat
1581570Eae17Experimental allergic encephalomyelitis QTL 174.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)138897350101631289Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1356056920101056920Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1380753256106807694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131101056920Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1374862117101339893Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 2 2 11 2 16
Low 1 42 48 32 8 32 8 10 37 30 20 11 8
Below cutoff 1 7 7 7 1 35 5 5

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001145828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006250376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008769826 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598733 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017598734 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090568 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090569 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090571 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039090572 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005492227 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AY197552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473985 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FJ750588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000004821   ⟹   ENSRNOP00000004821
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,634,840 - 94,657,738 (+)Ensembl
Rnor_6.0 Ensembl13101,381,510 - 101,385,764 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000094732   ⟹   ENSRNOP00000097755
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,634,801 - 94,657,738 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107238   ⟹   ENSRNOP00000086526
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,634,801 - 94,657,738 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109851   ⟹   ENSRNOP00000092561
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1394,640,323 - 94,657,738 (+)Ensembl
RefSeq Acc Id: NM_001145828   ⟹   NP_001139300
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,183,160 - 97,187,414 (+)NCBI
mRatBN7.21394,651,510 - 94,655,764 (+)NCBI
Rnor_6.013101,381,510 - 101,385,764 (+)NCBI
Rnor_5.013106,294,254 - 106,315,238 (+)NCBI
RGSC_v3.41399,025,501 - 99,029,755 (+)RGD
Celera1394,180,743 - 94,184,997 (+)RGD
Sequence:
RefSeq Acc Id: XM_039090568   ⟹   XP_038946496
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,166,471 - 97,190,642 (+)NCBI
mRatBN7.21394,634,778 - 94,656,489 (+)NCBI
RefSeq Acc Id: XM_039090569   ⟹   XP_038946497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,166,448 - 97,190,642 (+)NCBI
mRatBN7.21394,634,798 - 94,656,489 (+)NCBI
RefSeq Acc Id: XM_039090570   ⟹   XP_038946498
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,166,446 - 97,190,642 (+)NCBI
mRatBN7.21394,634,778 - 94,656,489 (+)NCBI
RefSeq Acc Id: XM_039090571   ⟹   XP_038946499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,166,469 - 97,190,642 (+)NCBI
mRatBN7.21394,634,778 - 94,656,489 (+)NCBI
RefSeq Acc Id: XM_039090572   ⟹   XP_038946500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,166,471 - 97,190,642 (+)NCBI
mRatBN7.21394,634,778 - 94,656,489 (+)NCBI
RefSeq Acc Id: XM_063272173   ⟹   XP_063128243
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,166,430 - 97,190,642 (+)NCBI
RefSeq Acc Id: XR_005492227
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81397,166,469 - 97,190,642 (+)NCBI
mRatBN7.21394,634,778 - 94,658,992 (+)NCBI
RefSeq Acc Id: NP_001139300   ⟸   NM_001145828
- UniProtKB: G3V6F8 (UniProtKB/TrEMBL),   A6JGM7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000004821   ⟸   ENSRNOT00000004821
RefSeq Acc Id: XP_038946496   ⟸   XM_039090568
- Peptide Label: isoform X1
- UniProtKB: G3V6F8 (UniProtKB/TrEMBL),   A6JGM7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946500   ⟸   XM_039090572
- Peptide Label: isoform X2
- UniProtKB: C0LP03 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946499   ⟸   XM_039090571
- Peptide Label: isoform X2
- UniProtKB: C0LP03 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946498   ⟸   XM_039090570
- Peptide Label: isoform X1
- UniProtKB: G3V6F8 (UniProtKB/TrEMBL),   A6JGM7 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038946497   ⟸   XM_039090569
- Peptide Label: isoform X1
- UniProtKB: G3V6F8 (UniProtKB/TrEMBL),   A6JGM7 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000097755   ⟸   ENSRNOT00000094732
Ensembl Acc Id: ENSRNOP00000086526   ⟸   ENSRNOT00000107238
Ensembl Acc Id: ENSRNOP00000092561   ⟸   ENSRNOT00000109851
RefSeq Acc Id: XP_063128243   ⟸   XM_063272173
- Peptide Label: isoform X1
- UniProtKB: A6JGM7 (UniProtKB/TrEMBL),   G3V6F8 (UniProtKB/TrEMBL)
Protein Domains
TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-G3V6F8-F1-model_v2 AlphaFold G3V6F8 1-871 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:631351 AgrOrtholog
BioCyc Gene G2FUF-17055 BioCyc
Ensembl Genes ENSRNOG00000022067 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004821.5 UniProtKB/TrEMBL
  ENSRNOT00000094732.1 UniProtKB/TrEMBL
  ENSRNOT00000107238.1 UniProtKB/TrEMBL
  ENSRNOT00000109851.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report rno:289337 UniProtKB/TrEMBL
NCBI Gene 289337 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  PTHR24365:SF525 UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PhenoGen Tlr5 PhenoGen
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000022067 RatGTEx
SMART LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
UniProt A6JGM7 ENTREZGENE, UniProtKB/TrEMBL
  C0LP03 ENTREZGENE, UniProtKB/TrEMBL
  G3V6F8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-11 Tlr5  toll-like receptor 5      Symbol and Name status set to approved 625702 APPROVED