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Gene: Tlr5 (toll-like receptor 5) Rattus norvegicus

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Symbol:

Tlr5

Name:

toll-like receptor 5

RGD ID:

631351

Description:

Predicted to enable interleukin-1 receptor binding activity and pattern recognition receptor activity. Involved in cellular response to lipopolysaccharide; male gonad development; and positive regulation of nitric oxide biosynthetic process. Predicted to be active in plasma membrane. Biomarker of perinatal necrotizing enterocolitis. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5); PARTICIPATES IN Toll-like receptor signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TLR5 (toll like receptor 5)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Tlr5 (toll-like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tlr5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TLR5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	TLR5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tlr5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TLR5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TLR5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tlr5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Tlr5 (toll-like receptor 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	TLR5 (toll like receptor 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tlr5b (toll-like receptor 5b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	tlr5a (toll-like receptor 5a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Tehao	Alliance	DIOPT (Ensembl Compara\|PANTHER)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	97,166,430 - 97,190,642 (+)	NCBI		GRCr8
mRatBN7.2	13	94,634,778 - 94,658,992 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	94,634,801 - 94,657,738 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	97,156,784 - 97,161,038 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	98,556,697 - 98,560,951 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	95,738,872 - 95,743,126 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	101,364,784 - 101,385,764 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	101,381,510 - 101,385,764 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	106,294,254 - 106,315,238 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	99,025,501 - 99,029,755 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	99,217,286 - 99,217,523 (+)	NCBI
Celera	13	94,180,743 - 94,184,997 (+)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult respiratory distress syndrome (ISO)

alcohol use disorder (ISO)

ankylosing spondylitis (ISO)

Bacterial Keratitis (ISO)

bacterial pneumonia (ISO)

Chemical and Drug Induced Liver Injury (ISO)

chronic granulomatous disease (ISO)

cystic fibrosis (ISO)

cystitis (ISO)

gastrointestinal stromal tumor (ISO)

Hyperammonemia (ISO)

Legionnaires' disease (ISO)

melioidosis (ISO)

membranoproliferative glomerulonephritis (ISO)

parathyroid carcinoma (ISO)

perinatal necrotizing enterocolitis (IEP)

Prostatic Neoplasms (ISO)

Pseudomonas Infections (ISO)

Salmonella Infections, Animal (IEP)

systemic lupus erythematosus (ISO)

Tongue Neoplasms (ISO)

Viral Bronchiolitis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (ISO)

acetamide (EXP)

aflatoxin B1 (EXP)

ammonium chloride (EXP)

aripiprazole (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

bromobenzene (EXP)

butyric acid (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

clofibrate (ISO)

corticosterone (ISO)

deoxynivalenol (ISO)

dichloroacetic acid (ISO)

diiodine (ISO)

ethanol (ISO)

ferric oxide (EXP)

furan (ISO)

gentamycin (EXP)

inulin (ISO)

lead diacetate (ISO)

linuron (ISO)

lipopolysaccharide (EXP)

manganese(II) chloride (EXP)

metformin (ISO)

methamphetamine (ISO)

methapyrilene (ISO)

nickel atom (ISO)

ozone (ISO)

paclitaxel (ISO)

paracetamol (EXP,ISO)

parthenolide (ISO)

pentachlorophenol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

permethrin (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

progesterone (ISO)

Pyridostigmine bromide (ISO)

resveratrol (ISO)

rotenone (EXP)

silicon dioxide (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

tamoxifen (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

titanium atom (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to lipopolysaccharide (IEP)

cellular response to mechanical stimulus (ISO)

immune response (IEA)

immune system process (IEA)

inflammatory response (IBA,IEA)

innate immune response (IEA)

male gonad development (IEP)

positive regulation of cytokine production (IEA)

positive regulation of interleukin-8 production (ISO)

positive regulation of nitric oxide biosynthetic process (IDA)

regulation of tumor necrosis factor production (IEA)

signal transduction (IEA)

toll-like receptor 5 signaling pathway (ISO)

toll-like receptor signaling pathway (IBA,IEA)

Cellular Component

membrane (IEA)

plasma membrane (IBA,ISO)

Molecular Function

interleukin-1 receptor binding (ISO)

pattern recognition receptor activity (ISO)

protein binding (ISO)

signaling receptor activity (IBA)

transmembrane signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Toll-like receptor signaling pathway (IDA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5.	Assassi S, etal., J Rheumatol. 2011 Jan;38(1):87-98. doi: 10.3899/jrheum.100469. Epub 2010 Oct 15.
2.	In vitro and ex vivo activation of the TLR5 signaling pathway in intestinal epithelial cells by a commensal Escherichia coli strain.	Bambou JC, etal., J Biol Chem 2004 Oct 8;279(41):42984-92. Epub 2004 Aug 9.
3.	TLR4 links podocytes with the innate immune system to mediate glomerular injury.	Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
4.	Identification of Toll-like receptors in the rat (Rattus norvegicus): messenger RNA expression in the male reproductive tract under conditions of androgen variation.	Biswas B, etal., Am J Reprod Immunol. 2009 Oct;62(4):243-52. Epub 2009 Aug 24.
5.	TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis.	Blohmke CJ, etal., J Immunol. 2010 Dec 15;185(12):7731-8. Epub 2010 Nov 10.
6.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression.	Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
8.	Dysregulation of innate immune receptors on neutrophils in chronic granulomatous disease.	Hartl D, etal., J Allergy Clin Immunol. 2008 Feb;121(2):375-382.e9. Epub 2007 Dec 26.
9.	A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease.	Hawn TR, etal., J Exp Med. 2003 Nov 17;198(10):1563-72.
10.	Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila.	Hawn TR, etal., J Immunol. 2007 Nov 15;179(10):6981-7.
11.	Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women.	Hawn TR, etal., PLoS One. 2009 Jun 22;4(6):e5990. doi: 10.1371/journal.pone.0005990.
12.	Toll-like receptors and their adaptors are regulated in macrophages after phagocytosis of lipopolysaccharide-coated titanium particles.	Hirayama T, etal., J Orthop Res. 2011 Feb 9. doi: 10.1002/jor.21369.
13.	Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue.	Kauppila JH, etal., Br J Cancer. 2013 Feb 19;108(3):638-43. doi: 10.1038/bjc.2012.589. Epub 2013 Jan 3.
14.	TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease.	Koller B, etal., J Immunol. 2008 Aug 15;181(4):2753-63.
15.	Pathogen recognition by the innate immune system.	Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
16.	Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis.	Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
17.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
18.	Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia.	Morris AE, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1112-9. Epub 2009 Oct 2.
19.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
20.	Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage.	Oshikawa K and Sugiyama Y, Biochem Biophys Res Commun. 2003 Jun 6;305(3):649-55.
21.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
22.	Effects of mannoprotein E1 in liquid diet on inflammatory response and TLR5 expression in the gut of rats infected by Salmonella typhimurium.	Posadas SJ, etal., BMC Gastroenterol. 2010 Jun 8;10:58.
23.	GOA pipeline	RGD automated data pipeline
24.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
26.	Comprehensive gene review and curation	RGD comprehensive gene curation
27.	Bacterial flagellin triggers cardiac innate immune responses and acute contractile dysfunction.	Rolli J, etal., PLoS One. 2010 Sep 13;5(9):e12687.
28.	Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.	Siezen CL, etal., Pediatr Infect Dis J. 2009 Apr;28(4):333-5.
29.	Increased Toll-like Receptor-MyD88-NFκB-Proinflammatory neuroimmune signaling in the orbitofrontal cortex of humans with alcohol use disorder.	Vetreno RP, etal., Alcohol Clin Exp Res. 2021 Sep;45(9):1747-1761. doi: 10.1111/acer.14669. Epub 2021 Aug 20.
30.	Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis).	Wiersinga WJ, etal., PLoS Med. 2007 Jul 31;4(7):e248.
31.	Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide.	Yu FS, etal., J Immunol. 2010 Jul 15;185(2):1142-9. Epub 2010 Jun 21.
32.	Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection.	Zhou R, etal., Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.

Additional References at PubMed

PMID:12925853	PMID:15788393	PMID:17128265	PMID:18592153	PMID:19593445	PMID:21985371	PMID:24091496	PMID:27760316	PMID:28685867	PMID:33042267	PMID:33673008	PMID:34898357

Genomics

Comparative Map Data

Tlr5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	97,166,430 - 97,190,642 (+)	NCBI		GRCr8
mRatBN7.2	13	94,634,778 - 94,658,992 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	94,634,801 - 94,657,738 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	97,156,784 - 97,161,038 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	98,556,697 - 98,560,951 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	95,738,872 - 95,743,126 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	101,364,784 - 101,385,764 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	101,381,510 - 101,385,764 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	106,294,254 - 106,315,238 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	99,025,501 - 99,029,755 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	99,217,286 - 99,217,523 (+)	NCBI
Celera	13	94,180,743 - 94,184,997 (+)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

TLR5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	223,109,404 - 223,143,248 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	223,109,404 - 223,143,292 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	223,282,746 - 223,316,590 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	221,350,207 - 221,383,247 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	196,502,104 - 196,535,977 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI
HuRef	1	193,957,238 - 193,991,230 (-)	NCBI		HuRef
CHM1_1	1	224,555,804 - 224,589,771 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	222,347,318 - 222,381,267 (-)	NCBI		T2T-CHM13v2.0

Tlr5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	182,782,317 - 182,804,010 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	182,782,353 - 182,804,010 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	182,954,752 - 182,976,044 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	182,954,788 - 182,976,044 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	184,884,919 - 184,906,175 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	184,884,919 - 184,906,170 (+)	NCBI		MGSCv36	mm8
Celera	1	189,998,902 - 190,020,262 (+)	NCBI		Celera
Cytogenetic Map	1	H5	NCBI
cM Map	1	86.12	NCBI

Tlr5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955520	1,556,523 - 1,559,093 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955520	1,544,840 - 1,562,081 (+)	NCBI	ChiLan1.0	ChiLan1.0

TLR5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	26,171,713 - 26,204,781 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	26,127,751 - 26,160,814 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	198,787,046 - 198,819,537 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	203,797,720 - 203,831,605 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	203,798,767 - 203,801,343 (-)	Ensembl	panpan1.1		panPan2

TLR5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	23,700,323 - 23,705,628 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	23,702,033 - 23,705,314 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	23,729,352 - 23,731,928 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	23,873,004 - 23,878,847 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	23,874,719 - 23,878,000 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	23,620,126 - 23,622,702 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	24,170,412 - 24,172,988 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	24,572,699 - 24,575,275 (+)	NCBI		UU_Cfam_GSD_1.0

Tlr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	54,334,832 - 54,363,906 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936526	383,418 - 401,552 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936526	383,490 - 387,007 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TLR5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	19,387,666 - 19,410,024 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	19,387,666 - 19,410,024 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	21,886,309 - 21,888,880 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TLR5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	6,418,895 - 6,440,433 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	6,437,638 - 6,440,211 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	6,652,060 - 6,685,032 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tlr5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624835	5,500,461 - 5,503,034 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624835	5,495,723 - 5,503,462 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tlr5
214 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	343
Count of miRNA genes:	193
Interacting mature miRNAs:	220
Transcripts:	ENSRNOT00000004821
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
7207885	Glom27	Glomerulus QTL 27	3.9		kidney glomerulus integrity trait (VT:0010546)	kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)	13	20605871	101339738	Rat
7387280	Uae43	Urinary albumin excretion QTL 43	5.69	0.4174	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	13	66451204	106807694	Rat
2293702	Bss34	Bone structure and strength QTL 34	4.61	0.0001	femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	13	65103704	106807694	Rat
1354621	Rf47	Renal function QTL 47	3.7		kidney renin amount (VT:0010559)	kidney renin level (CMO:0002166)	13	30395351	101056920	Rat
1354655	Bp241	Blood pressure QTL 241	3.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	56056920	101056920	Rat
4889606	Gluco63	Glucose level QTL 63	2.86	0.003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	13	80753256	106807694	Rat
8655959	Pur32	Proteinuria QTL 32	8.4		urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	13	74023918	97213863	Rat
1641901	Alcrsp6	Alcohol response QTL 6			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	13	52362171	97362171	Rat
2293687	Bss26	Bone structure and strength QTL 26	4.6	0.0001	femur morphology trait (VT:0000559)	femur cross-sectional area (CMO:0001661)	13	65103704	106807694	Rat
12879475	Bp400	Blood pressure QTL 400			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	13	61825626	106807694	Rat
1581570	Eae17	Experimental allergic encephalomyelitis QTL 17	4.1		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	13	8897350	101631289	Rat
1354666	Bp244	Blood pressure QTL 244	4.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	13	1	101056920	Rat
2293341	Glom15	Glomerulus QTL 15	9.1		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	13	74862117	101339893	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	111	91	90	59	25	59	6	217	96	91	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001145828	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006250376	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008769826	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598732	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598733	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017598734	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090569	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090570	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039090572	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063272173	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005492227	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY197552	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FJ750588	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000013	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000004821 ⟹ ENSRNOP00000004821

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	94,634,840 - 94,657,738 (+)	Ensembl
Rnor_6.0 Ensembl	13	101,381,510 - 101,385,764 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000094732 ⟹ ENSRNOP00000097755

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	94,634,801 - 94,657,738 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000107238 ⟹ ENSRNOP00000086526

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	94,634,801 - 94,657,738 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000109851 ⟹ ENSRNOP00000092561

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	13	94,640,323 - 94,657,738 (+)	Ensembl

RefSeq Acc Id:

NM_001145828 ⟹ NP_001139300

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	97,183,160 - 97,187,414 (+)	NCBI
mRatBN7.2	13	94,651,510 - 94,655,764 (+)	NCBI
Rnor_6.0	13	101,381,510 - 101,385,764 (+)	NCBI
Rnor_5.0	13	106,294,254 - 106,315,238 (+)	NCBI
RGSC_v3.4	13	99,025,501 - 99,029,755 (+)	RGD
Celera	13	94,180,743 - 94,184,997 (+)	RGD

Sequence:

show sequence

TTGAAATCTCGTAGCCCAGTTGCAGTGATCGGCTCCCTTCAATCTATTCCACCTGATCCTAATC
CTTTCAAAGAGCTCTACTCCCCGGTCACTAAGCATTTTAAATAGATGCGCCTATGGGGCCATTC
CGAAGATATCAGCTCTCTGCCATCCTTGTTAATTCTTTTCTCCTCTTACACAGCACCTGTGCTC
GGAGCCTATGCCAGACACATCTGTGAGACTCCCTTCGCCGCTGCAGCACACGGAGGGGTGCTGA
GTTCCTCACTTTTACGACAAGCGTCAGTGGGTGGGTGTATTTCTACTTTACCTTACACTCTCAC
ACAGCCATGCCTGTCAGGCATGAAGCGGGCGGATAATCCACTCAATTCGGGAGATCAAGTCAGA
TCCTTTATCAAGATGCATAGAGCGCCCAGTGCCTGTATTACGATCTTGGATCTTTGGGGGGATG
GGGTAGAGTCTGGGACAGAACACAGCACAGAAACTGAAGTGCTTATTGTCTGACCATCAGCTAA
GATTCTGGGAGCTAGGAATGGGACCGTCTTGGATGAACAGAAGTAAAAATGCCCCTTCTTTATG
ACTTTTGACGTCCCTCAGCCACTCTGGAATGGATGAACAAACACTGATACGGGTAATACATAGT
CTTGTTGCTGCTTGTTGATGCTGGGAGGAAACCTAGGACCTAGCACGTGCTAGGCAAGTACTCT
ACCACTGGGCTACCTCACCAGCTTGTATGAAATATCCATGAGGTACTGGGGCCCAGTGTGTAGA
GAAGAAAAGCGTGGGTGTCTCAGTTCCACCAAGTCCGCCAACAAGAAGAATGTACCAGCAGAAT
GTTTATGGAGCCAGCTGAGCAAAGGGTTCTAAGAGGACAGCACCCTCACCCAGGAGACCCTTCA
GCGCTGAGGACCCATGTGCCGAGCCTCAGGCTGTGATGTGGTGTTTTTATTCTCTCTTTTCCCA
TAGGATCATGGCGTATCAGCTTGACCTTCTCATAGGCGTGGTCTTCATGGCCAGCCCCGTGTTA
GAAATGTCTCCCTGCTTCTCTGATGGCCGGATAGCCTTATTCCGAGGTTGTAACCTTACCCAGA
TTCCCTGGGTCCTCAACACGACTGAGAGGCTCCTACTCAGCTTCAATTACATCAGTACGGTTGT
CACCACATCGTTTCCACTCCTGGAGCAGCTCCTGCTACTGGAGCTGGGGACCCAGTATGCTCGC
TTGACAATTGGCCAGGAGGCCTTCCGAAACCTGCCCAACCTCAGGATCTTAGACCTGGGCCAGA
GCCAGATTGAAGTCTTGAATCCAGACGCTTTTCAGGGACTGCCCCATCTCTTCGAACTTCGGCT
GTTTGACTGTGGACTCTCCAATGCTGTATTAAGGGACGCTTACTTCAGAAATCTAAATTCACTA
GCTCGCTTAGACCTCTCTGCCAACGAGATTCACAGCCTTCACCTCCACTCTTCATTTCAGGAAC
TGAGTTCCTTAAGCGATATAAATTTTTCTTTCAACCGGATATTCACTTTATGTGAAGATGAACT
CCAGCCTCTCCAGGGCAGAACACTTTCTTTCTTTGGCCTCAAATCAACCAGCCTGTTCAGCAGA
GTCTTCGTGGACTGGGAGGCATGCAGGAACCCCCTCAGAGGCATAAGGCTAGAGACTCTAGACC
TTTCTGAAAATGGCTGGACAGCGGCCATCTTAGGGAACTTCAGCCACACCATCCAGGGAAGCCA
CATTTCCTCTTTGATTCTTACATACCACATCATGGGTTCTGGCTTTGGCTTCCAGAACATCAAA
GATCCCGACCAGAGCACATTTGCCAGCCTGGCCAGGAGTTCGGTGCTACAACTGGACCTTTCAC
ACGGCTATATCTTCTCCTTGAACCCCCGACTGTTTGAGACGCTGAAGGATTTGAAGAAGCTGAA
CCTTGCCTTCAACAAGATAAACAAGATCAGCGATTACGCGTTTCATGGACTCGACAGCCTACAG
ATTCTCAATCTATCCTATAATCTTTTGGGAGAACTCTACAATTCCAACTTCTATGGGCTTCCTA
GCATAGCCTACCTTGACCTTCAAAGGAACCACATTGGGATCATTCAAGACCGAACATTCAGATT
ATTAAAAAAGCTACAAACCTTAGATCTCCGTGACAATGCTCTTAAAACCATTGGTTTTATTCCA
AGTGTACAGATGGTCCTCCTGGGTAGCAATAAGCTGACCCATTTGCCACACGTCCGCTTTACCG
CCAACTTCATAGAGTTATCTGAAAATGGGCTAGAAAATCTGTCTGACCTCTACTTCCTCCTGCG
AATCCCCGGTCTCCAGTTTCTCATCCTAAATCAGAACCGCCTTTCGTCCTGCAGCAATGTGGAC
TACGCCCCTTCCCAGAACCTGAGCTTAGAACAGCTTTTCCTTGCAGAGAACATGCTACAGCTCG
CCTGGGAGACCGGCCTCTGTTGGGATATTTTTAAAGGCCTTTCCCGCCTCCAAATCCTTTACCT
GAATAATAACTACCTTAATTTCCTCCCGCCCGGAATATTTAACGGCCTGGTTGCATTACGGATG
CTCAGTCTCAGTGCTAACAGGCTAACCATGCTCTCTCCGGGCAGTTTACCTGCTAATTTAGAGA
TTCTCGACATATCTAGAAATCAGCTTTTCTCTCCCGACCCTGGTTTGTTTTCTTCGCTCCGTGC
CTTGGACATAACTCACAACGAGTTCATCTGTGACTGTGAACTTAGCACTTTTATCGTCTGGCTC
AACCAAACCAATGTCACCCTATTCGGTTCTCCTGCAGATGTATATTGCATGTACCCCAATTCAC
TGCTAGGGAGCTCCCTCTACAACATATCCACCAAGGACTGCGATGAAGAGGAAGCCGTGCGCTC
CCTAAACTTTTCCCTTTTCATCCTGTGCACAGTCACTTTGACTCTGTTCCTCGTCATCACCCTC
ATAGTCACAAAATTCCGGGGGATTTGTTTCCTGTGTTTTAAGACCATCCAGAAACTGATGTTTA
AGGGCAAGTTCCGGAATCCGGAACCTAGCGCATACAGATATGACGCCTACTTCTGCTTCAGTAG
CAAAGACTTTGAATGGGCACAGAACGCGCTGCTCAAACACCTGGATGCTCAGTACAGTTCCCAA
AACAGGCTCAGGCTGTGCTTTGAAGAAAGAGATTTCATTCCGGGGGAAAACCATATCTCCAACA
TCCAGGCAGCTGTCTGGGGCAGCAGAAAGACGGTATGTCTAGTAAGCAGACACTTCCTTAAGGA
TGGCTGGTGCCTGGAAGCCTTCAGGTATGCCCAGAGCCGGTGTCTGTCTGACCTCAAGCGTGTT
CTCATCGTGGTAGTGGTGGGTTCGCTGCCCCAGTATCAGCTAATGAGACATGAGACCATCAGAG
GGTTTCTGCAAAAGCAGCAGTATTTGAGGTGGCCCGAGGACCTCCAGGATGTTGACTGGTTTCT
CGATAAACTGTCTGGATGCATACTGAAGGAAGAGAAAGGAAAGAAGAGAAGCAGTCCCATTCAG
TTGCGAACCATAAGGACGGTTTCCTAGTGATCGGAAGGAACATTTTGCAAGCACCGCAAATAGC
TCTCTGACTGGACGTGCGTAGCCATTGGGGGTCCTTCCCCGGGGTCGCTTTCTGTCTATGAAAA
CAATATCGATTTCTTGATTTTCGTGTCAACAGGGTGCTTTGTCTCGGTGACCTCCAAATGGAAA
GTAATAGGTCCAGAAAACTGCAGCTGCCTCTAAGGACTCTCACCTGCCATTGATTTCCTCTCAA
GCCCAATAACACCATTTCCTCCCATCCTGTTGCCTACTGCCAGCCACCCAGATGGCAAGGGCAC
CTTGGGAGAAGTTACAGGTGGCTTCATGCTTTCTGTGCTGTTCCGTTCAAAAGCAGGTGGCTTG
AGAATCCTGGGGTCTTAATGCTCTGCAGAACATGGACAGATGAGATAGATCCTTCTCTGGCCAT
AGGCTCTCACTCCACTAAGTGCACACATGATAGGAAGTTGGACAGACAGACGGATGGCAGCAGC
CCCATCGCTGTGGTCATGATGCACTAACTTCCTGTTCTGACCCTGCAGGCCCAGCTTCTGTGGG
CCACAGCCATCTTCTGCACGGGACCTCTCGACCTGACATTCACGCCCTTTCACCCGCCTAACTG
TTCTTCTTTCTTCCCCACAACTATACGACAGCTGTTGTATCAGGTACACAACAGCTATAGAAAG
GATGTGGCGTTCACACACCAATTCCTTACTG

hide sequence

RefSeq Acc Id:

XM_039090568 ⟹ XP_038946496

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	97,166,471 - 97,190,642 (+)	NCBI
mRatBN7.2	13	94,634,778 - 94,656,489 (+)	NCBI

RefSeq Acc Id:

XM_039090569 ⟹ XP_038946497

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	97,166,448 - 97,190,642 (+)	NCBI
mRatBN7.2	13	94,634,798 - 94,656,489 (+)	NCBI

RefSeq Acc Id:

XM_039090570 ⟹ XP_038946498

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	97,166,446 - 97,190,642 (+)	NCBI
mRatBN7.2	13	94,634,778 - 94,656,489 (+)	NCBI

RefSeq Acc Id:

XM_039090571 ⟹ XP_038946499

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	97,166,469 - 97,190,642 (+)	NCBI
mRatBN7.2	13	94,634,778 - 94,656,489 (+)	NCBI

RefSeq Acc Id:

XM_039090572 ⟹ XP_038946500

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	97,166,471 - 97,190,642 (+)	NCBI
mRatBN7.2	13	94,634,778 - 94,656,489 (+)	NCBI

RefSeq Acc Id:

XM_063272173 ⟹ XP_063128243

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	97,166,430 - 97,190,642 (+)	NCBI

RefSeq Acc Id:

XR_005492227

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	13	97,166,469 - 97,190,642 (+)	NCBI
mRatBN7.2	13	94,634,778 - 94,658,992 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001139300	(Get FASTA)	NCBI Sequence Viewer
	XP_038946496	(Get FASTA)	NCBI Sequence Viewer
	XP_038946497	(Get FASTA)	NCBI Sequence Viewer
	XP_038946498	(Get FASTA)	NCBI Sequence Viewer
	XP_038946499	(Get FASTA)	NCBI Sequence Viewer
	XP_038946500	(Get FASTA)	NCBI Sequence Viewer
	XP_063128243	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAO62341	(Get FASTA)	NCBI Sequence Viewer
	ACN60145	(Get FASTA)	NCBI Sequence Viewer
	EDL94883	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000004821.3
	ENSRNOP00000086526
	ENSRNOP00000086526.1
	ENSRNOP00000092561
	ENSRNOP00000092561.1
	ENSRNOP00000097755.1
	ENSRNOP00000102645
	ENSRNOP00000107039
	ENSRNOP00000107919

RefSeq Acc Id:

NP_001139300 ⟸ NM_001145828

- UniProtKB:

G3V6F8 (UniProtKB/TrEMBL), A6JGM7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MWCFYSLFSHRIMAYQLDLLIGVVFMASPVLEMSPCFSDGRIALFRGCNLTQIPWVLNTTERLL
LSFNYISTVVTTSFPLLEQLLLLELGTQYARLTIGQEAFRNLPNLRILDLGQSQIEVLNPDAFQ
GLPHLFELRLFDCGLSNAVLRDAYFRNLNSLARLDLSANEIHSLHLHSSFQELSSLSDINFSFN
RIFTLCEDELQPLQGRTLSFFGLKSTSLFSRVFVDWEACRNPLRGIRLETLDLSENGWTAAILG
NFSHTIQGSHISSLILTYHIMGSGFGFQNIKDPDQSTFASLARSSVLQLDLSHGYIFSLNPRLF
ETLKDLKKLNLAFNKINKISDYAFHGLDSLQILNLSYNLLGELYNSNFYGLPSIAYLDLQRNHI
GIIQDRTFRLLKKLQTLDLRDNALKTIGFIPSVQMVLLGSNKLTHLPHVRFTANFIELSENGLE
NLSDLYFLLRIPGLQFLILNQNRLSSCSNVDYAPSQNLSLEQLFLAENMLQLAWETGLCWDIFK
GLSRLQILYLNNNYLNFLPPGIFNGLVALRMLSLSANRLTMLSPGSLPANLEILDISRNQLFSP
DPGLFSSLRALDITHNEFICDCELSTFIVWLNQTNVTLFGSPADVYCMYPNSLLGSSLYNISTK
DCDEEEAVRSLNFSLFILCTVTLTLFLVITLIVTKFRGICFLCFKTIQKLMFKGKFRNPEPSAY
RYDAYFCFSSKDFEWAQNALLKHLDAQYSSQNRLRLCFEERDFIPGENHISNIQAAVWGSRKTV
CLVSRHFLKDGWCLEAFRYAQSRCLSDLKRVLIVVVVGSLPQYQLMRHETIRGFLQKQQYLRWP
EDLQDVDWFLDKLSGCILKEEKGKKRSSPIQLRTIRTVS

hide sequence

Ensembl Acc Id:

ENSRNOP00000004821 ⟸ ENSRNOT00000004821

RefSeq Acc Id:	XP_038946496 ⟸ XM_039090568
- Peptide Label:	isoform X1
- UniProtKB:	G3V6F8 (UniProtKB/TrEMBL), A6JGM7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946500 ⟸ XM_039090572
- Peptide Label:	isoform X2
- UniProtKB:	C0LP03 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946499 ⟸ XM_039090571
- Peptide Label:	isoform X2
- UniProtKB:	C0LP03 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946498 ⟸ XM_039090570
- Peptide Label:	isoform X1
- UniProtKB:	G3V6F8 (UniProtKB/TrEMBL), A6JGM7 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038946497 ⟸ XM_039090569
- Peptide Label:	isoform X1
- UniProtKB:	G3V6F8 (UniProtKB/TrEMBL), A6JGM7 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000097755 ⟸ ENSRNOT00000094732

Ensembl Acc Id:

ENSRNOP00000086526 ⟸ ENSRNOT00000107238

Ensembl Acc Id:

ENSRNOP00000092561 ⟸ ENSRNOT00000109851

RefSeq Acc Id:	XP_063128243 ⟸ XM_063272173
- Peptide Label:	isoform X1
- UniProtKB:	A6JGM7 (UniProtKB/TrEMBL), G3V6F8 (UniProtKB/TrEMBL)

Protein Domains

TIR

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-G3V6F8-F1-model_v2	AlphaFold	G3V6F8	1-871	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:631351	AgrOrtholog
BioCyc Gene	G2FUF-17055	BioCyc
Ensembl Genes	ENSRNOG00000022067	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000004821.5	UniProtKB/TrEMBL
	ENSRNOT00000094732.1	UniProtKB/TrEMBL
	ENSRNOT00000107238	ENTREZGENE
	ENSRNOT00000107238.1	UniProtKB/TrEMBL
	ENSRNOT00000109851	ENTREZGENE
	ENSRNOT00000109851.1	UniProtKB/TrEMBL
	ENSRNOT00000127807	ENTREZGENE
	ENSRNOT00000136113	ENTREZGENE
	ENSRNOT00000145129	ENTREZGENE
Gene3D-CATH	3.40.50.10140	UniProtKB/TrEMBL
	3.80.10.10	UniProtKB/TrEMBL
InterPro	Cys-rich_flank_reg_C	UniProtKB/TrEMBL
	L_dom-like	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	TIR_dom	UniProtKB/TrEMBL
	Toll-like_receptor	UniProtKB/TrEMBL
	Toll_tir_struct_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:289337	UniProtKB/TrEMBL
NCBI Gene	289337	ENTREZGENE
PANTHER	PTHR24365	UniProtKB/TrEMBL
	PTHR24365:SF525	UniProtKB/TrEMBL
Pfam	LRR_1	UniProtKB/TrEMBL
	LRR_8	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
PhenoGen	Tlr5	PhenoGen
PIRSF	Toll-like_receptor	UniProtKB/TrEMBL
PROSITE	LRR	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000022067	RatGTEx
SMART	LRR_SD22	UniProtKB/TrEMBL
	LRR_TYP	UniProtKB/TrEMBL
	LRRCT	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
UniProt	A6JGM7	ENTREZGENE, UniProtKB/TrEMBL
	C0LP03	ENTREZGENE, UniProtKB/TrEMBL
	G3V6F8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-02-11	Tlr5	toll-like receptor 5			Symbol and Name status set to approved	625702	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

RGD Manual Annotations

Imported Annotations - KEGG (archival)