TLR5 (toll like receptor 5) - Rat Genome Database

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Gene: TLR5 (toll like receptor 5) Sus scrofa
Analyze
Symbol: TLR5
Name: toll like receptor 5
RGD ID: 14246979
Description: ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to mechanical stimulus (ortholog); male gonad development (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); ankylosing spondylitis (ortholog); Bacterial Keratitis (ortholog); FOUND IN membrane (ortholog); INTERACTS WITH cadmium nitrate
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: toll-like receptor 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1019,387,666 - 19,410,024 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11019,387,666 - 19,410,024 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21021,886,309 - 21,888,880 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16604477   PMID:23132291   PMID:24097563   PMID:24684626   PMID:32715918  


Genomics

Comparative Map Data
TLR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1019,387,666 - 19,410,024 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11019,387,666 - 19,410,024 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21021,886,309 - 21,888,880 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381223,109,404 - 223,143,248 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1223,109,404 - 223,143,248 (-)EnsemblGRCh38hg38GRCh38
GRCh371223,282,746 - 223,316,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,350,207 - 221,383,247 (-)NCBINCBI36hg18NCBI36
Celera1196,502,104 - 196,535,977 (-)NCBI
Cytogenetic Map1q41NCBI
HuRef1193,957,238 - 193,991,230 (-)NCBIHuRef
CHM1_11224,555,804 - 224,589,771 (-)NCBICHM1_1
T2T-CHM13v2.01222,347,318 - 222,381,267 (-)NCBI
Tlr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,782,317 - 182,804,010 (+)NCBIGRCm39mm39
GRCm39 Ensembl1182,782,353 - 182,804,010 (+)Ensembl
GRCm381182,954,752 - 182,976,044 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,954,788 - 182,976,044 (+)EnsemblGRCm38mm10GRCm38
MGSCv371184,884,919 - 184,906,175 (+)NCBIGRCm37mm9NCBIm37
MGSCv361184,884,919 - 184,906,170 (+)NCBImm8
Celera1189,998,902 - 190,020,262 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map186.12NCBI
Tlr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21394,634,778 - 94,658,992 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl1394,634,801 - 94,657,738 (+)Ensembl
Rnor_6.013101,364,784 - 101,385,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,381,510 - 101,385,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013106,294,254 - 106,315,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41399,025,501 - 99,029,755 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11399,217,286 - 99,217,523 (+)NCBI
Celera1394,180,743 - 94,184,997 (+)NCBICelera
Cytogenetic Map13q26NCBI
Tlr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,556,523 - 1,559,093 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBIChiLan1.0ChiLan1.0
TLR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11203,797,720 - 203,831,605 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1203,798,767 - 203,801,343 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01198,787,046 - 198,819,537 (-)NCBIMhudiblu_PPA_v0panPan3
TLR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13823,700,323 - 23,705,628 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3823,702,033 - 23,705,314 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3823,729,352 - 23,731,928 (+)NCBI
ROS_Cfam_1.03823,873,004 - 23,878,847 (+)NCBI
ROS_Cfam_1.0 Ensembl3823,874,719 - 23,878,000 (+)Ensembl
UMICH_Zoey_3.13823,620,126 - 23,622,702 (+)NCBI
UNSW_CanFamBas_1.03824,170,412 - 24,172,988 (+)NCBI
UU_Cfam_GSD_1.03824,572,699 - 24,575,275 (+)NCBI
Tlr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934454,334,832 - 54,363,906 (+)NCBI
SpeTri2.0NW_004936526383,490 - 387,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,418,895 - 6,440,433 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl256,437,638 - 6,440,211 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660556,652,060 - 6,685,032 (+)NCBIVero_WHO_p1.0
Tlr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248355,500,461 - 5,503,034 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248355,495,723 - 5,503,462 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 10 4 3 5 2 23 2 3 1
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000033032   ⟹   ENSSSCP00000061007
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1019,387,666 - 19,410,024 (-)Ensembl
RefSeq Acc Id: NM_001348771   ⟹   NP_001335700
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11019,387,666 - 19,410,024 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001335700 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACN42936 (Get FASTA)   NCBI Sequence Viewer  
  ACN71220 (Get FASTA)   NCBI Sequence Viewer  
  ADF32905 (Get FASTA)   NCBI Sequence Viewer  
  AGT79978 (Get FASTA)   NCBI Sequence Viewer  
  BAD91800 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001335700   ⟸   NM_001348771
- UniProtKB: C0L925 (UniProtKB/TrEMBL),   Q59HI7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000061007   ⟸   ENSSSCT00000033032
Protein Domains
TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010885 Ensembl, UniProtKB/TrEMBL
  ENSSSCG00005039747 UniProtKB/TrEMBL
  ENSSSCG00030061349 UniProtKB/TrEMBL
  ENSSSCG00035054485 UniProtKB/TrEMBL
  ENSSSCG00045038077 UniProtKB/TrEMBL
  ENSSSCG00055009002 UniProtKB/TrEMBL
  ENSSSCG00070004363 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000061007.1 UniProtKB/TrEMBL
  ENSSSCP00005039267.1 UniProtKB/TrEMBL
  ENSSSCP00005039285.1 UniProtKB/TrEMBL
  ENSSSCP00005039289.1 UniProtKB/TrEMBL
  ENSSSCP00030039565.1 UniProtKB/TrEMBL
  ENSSSCP00030039577.1 UniProtKB/TrEMBL
  ENSSSCP00030039593.1 UniProtKB/TrEMBL
  ENSSSCP00030039607.1 UniProtKB/TrEMBL
  ENSSSCP00030039612.1 UniProtKB/TrEMBL
  ENSSSCP00035029492.1 UniProtKB/TrEMBL
  ENSSSCP00035029497.1 UniProtKB/TrEMBL
  ENSSSCP00035029498.1 UniProtKB/TrEMBL
  ENSSSCP00035029502.1 UniProtKB/TrEMBL
  ENSSSCP00035029504.1 UniProtKB/TrEMBL
  ENSSSCP00045046643.1 UniProtKB/TrEMBL
  ENSSSCP00045046648.1 UniProtKB/TrEMBL
  ENSSSCP00045046660.1 UniProtKB/TrEMBL
  ENSSSCP00045046670.1 UniProtKB/TrEMBL
  ENSSSCP00045046681.1 UniProtKB/TrEMBL
  ENSSSCP00055013912.1 UniProtKB/TrEMBL
  ENSSSCP00055013929.1 UniProtKB/TrEMBL
  ENSSSCP00055013954.1 UniProtKB/TrEMBL
  ENSSSCP00055013973.1 UniProtKB/TrEMBL
  ENSSSCP00055013985.1 UniProtKB/TrEMBL
  ENSSSCP00070006763.1 UniProtKB/TrEMBL
  ENSSSCP00070006767.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000033032.3 UniProtKB/TrEMBL
  ENSSSCT00005063546.1 UniProtKB/TrEMBL
  ENSSSCT00005063572.1 UniProtKB/TrEMBL
  ENSSSCT00005063578.1 UniProtKB/TrEMBL
  ENSSSCT00030085794.1 UniProtKB/TrEMBL
  ENSSSCT00030085816.1 UniProtKB/TrEMBL
  ENSSSCT00030085849.1 UniProtKB/TrEMBL
  ENSSSCT00030085875.1 UniProtKB/TrEMBL
  ENSSSCT00030085888.1 UniProtKB/TrEMBL
  ENSSSCT00035072694.1 UniProtKB/TrEMBL
  ENSSSCT00035072706.1 UniProtKB/TrEMBL
  ENSSSCT00035072716.1 UniProtKB/TrEMBL
  ENSSSCT00035072727.1 UniProtKB/TrEMBL
  ENSSSCT00035072729.1 UniProtKB/TrEMBL
  ENSSSCT00045065867.1 UniProtKB/TrEMBL
  ENSSSCT00045065874.1 UniProtKB/TrEMBL
  ENSSSCT00045065890.1 UniProtKB/TrEMBL
  ENSSSCT00045065904.1 UniProtKB/TrEMBL
  ENSSSCT00045065915.1 UniProtKB/TrEMBL
  ENSSSCT00055017597.1 UniProtKB/TrEMBL
  ENSSSCT00055017619.1 UniProtKB/TrEMBL
  ENSSSCT00055017650.1 UniProtKB/TrEMBL
  ENSSSCT00055017677.1 UniProtKB/TrEMBL
  ENSSSCT00055017697.1 UniProtKB/TrEMBL
  ENSSSCT00070008231.1 UniProtKB/TrEMBL
  ENSSSCT00070008235.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  TLR5 UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:100144476 UniProtKB/TrEMBL
NCBI Gene TLR5 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  PTHR24365:SF525 UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP SSF52200 UniProtKB/TrEMBL
UniProt A0A4X1SUS0_PIG UniProtKB/TrEMBL
  A0A5G2QRZ6_PIG UniProtKB/TrEMBL
  A0A8D0LVU9_PIG UniProtKB/TrEMBL
  A0A8D0XUG0_PIG UniProtKB/TrEMBL
  A0A8D1JDA5_PIG UniProtKB/TrEMBL
  C0L925 ENTREZGENE, UniProtKB/TrEMBL
  Q59HI7 ENTREZGENE, UniProtKB/TrEMBL
  T1UMR1_PIG UniProtKB/TrEMBL