Tlr5 (toll like receptor 5) - Rat Genome Database

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Gene: Tlr5 (toll like receptor 5) Chinchilla lanigera
Analyze
Symbol: Tlr5
Name: toll like receptor 5
RGD ID: 9010445
Description: ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); pattern recognition receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to mechanical stimulus (ortholog); male gonad development (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); ankylosing spondylitis (ortholog); Bacterial Keratitis (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: toll-like receptor 5
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,556,523 - 1,559,093 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tlr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,556,523 - 1,559,093 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBIChiLan1.0ChiLan1.0
TLR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381223,109,404 - 223,143,248 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1223,109,404 - 223,143,292 (-)EnsemblGRCh38hg38GRCh38
GRCh371223,282,746 - 223,316,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,350,207 - 221,383,247 (-)NCBINCBI36Build 36hg18NCBI36
Celera1196,502,104 - 196,535,977 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1193,957,238 - 193,991,230 (-)NCBIHuRef
CHM1_11224,555,804 - 224,589,771 (-)NCBICHM1_1
T2T-CHM13v2.01222,347,318 - 222,381,267 (-)NCBIT2T-CHM13v2.0
Tlr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,782,317 - 182,804,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,782,353 - 182,804,010 (+)EnsemblGRCm39 Ensembl
GRCm381182,954,752 - 182,976,044 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,954,788 - 182,976,044 (+)EnsemblGRCm38mm10GRCm38
MGSCv371184,884,919 - 184,906,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,884,919 - 184,906,170 (+)NCBIMGSCv36mm8
Celera1189,998,902 - 190,020,262 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map186.12NCBI
Tlr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81397,166,430 - 97,190,642 (+)NCBIGRCr8
mRatBN7.21394,634,778 - 94,658,992 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,634,801 - 94,657,738 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1397,156,784 - 97,161,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,556,697 - 98,560,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01395,738,872 - 95,743,126 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,364,784 - 101,385,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,381,510 - 101,385,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013106,294,254 - 106,315,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41399,025,501 - 99,029,755 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11399,217,286 - 99,217,523 (+)NCBI
Celera1394,180,743 - 94,184,997 (+)NCBICelera
Cytogenetic Map13q26NCBI
TLR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2126,171,713 - 26,204,781 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1126,127,751 - 26,160,814 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01198,787,046 - 198,819,537 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11203,797,720 - 203,831,605 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1203,798,767 - 203,801,343 (-)Ensemblpanpan1.1panPan2
TLR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13823,700,323 - 23,705,628 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3823,702,033 - 23,705,314 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3823,729,352 - 23,731,928 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03823,873,004 - 23,878,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3823,874,719 - 23,878,000 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13823,620,126 - 23,622,702 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03824,170,412 - 24,172,988 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03824,572,699 - 24,575,275 (+)NCBIUU_Cfam_GSD_1.0
Tlr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934454,334,832 - 54,363,906 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936526383,418 - 401,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936526383,490 - 387,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1019,387,666 - 19,410,024 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11019,387,666 - 19,410,024 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21021,886,309 - 21,888,880 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,418,895 - 6,440,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,437,638 - 6,440,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660556,652,060 - 6,685,032 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248355,500,461 - 5,503,034 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248355,495,723 - 5,503,462 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000025665   ⟹   ENSCLAP00000025412
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049555201,556,523 - 1,559,093 (+)Ensembl
RefSeq Acc Id: XM_013507068   ⟹   XP_013362522
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013507069   ⟹   XP_013362523
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013507070   ⟹   XP_013362524
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013507071   ⟹   XP_013362525
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555201,552,880 - 1,562,081 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013507073   ⟹   XP_013362527
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013507074   ⟹   XP_013362528
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001231877
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001231878
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001231879
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBI
Sequence:
RefSeq Acc Id: XR_001231880
Type: NON-CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBI
Sequence:
RefSeq Acc Id: XP_013362522   ⟸   XM_013507068
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013362527   ⟸   XM_013507073
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YV18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362528   ⟸   XM_013507074
- Peptide Label: isoform X2
- UniProtKB: A0A8C2YV18 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013362523   ⟸   XM_013507069
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013362524   ⟸   XM_013507070
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013362525   ⟸   XM_013507071
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSCLAP00000025412   ⟸   ENSCLAT00000025665
Protein Domains
TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017491 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000025665 ENTREZGENE
  ENSCLAT00000025665.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
NCBI Gene Tlr5 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  PTHR24365:SF525 UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
SMART LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF52200 UniProtKB/TrEMBL
UniProt A0A8C2YV18 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Tlr5  toll like receptor 5    toll-like receptor 5  Symbol and/or name change 5135510 APPROVED