Tlr5 (toll-like receptor 5) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Tlr5 (toll-like receptor 5) Mus musculus
Analyze
Symbol: Tlr5
Name: toll-like receptor 5
RGD ID: 1331979
MGI Page MGI
Description: Predicted to enable interleukin-1 receptor binding activity and pattern recognition receptor activity. Predicted to be involved in inflammatory response; pattern recognition receptor signaling pathway; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in central nervous system; sensory organ; and trunk unsegmented mesenchyme. Human ortholog(s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5).
Type: protein-coding
RefSeq Status: VALIDATED
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,782,317 - 182,804,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,782,353 - 182,804,010 (+)EnsemblGRCm39 Ensembl
GRCm381182,954,752 - 182,976,044 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,954,788 - 182,976,044 (+)EnsemblGRCm38mm10GRCm38
MGSCv371184,884,919 - 184,906,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,884,919 - 184,906,170 (+)NCBIMGSCv36mm8
Celera1189,998,902 - 190,020,262 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map186.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal adipose tissue physiology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal eating behavior  (IAGP)
abnormal glucose homeostasis  (IAGP)
abnormal gut flora balance  (IAGP)
abnormal leukocyte migration  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal physiological response to xenobiotic  (IAGP)
abnormal response to transplant  (IAGP)
colitis  (IAGP)
decreased colon length  (IAGP)
decreased interleukin-12b secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased neutrophil cell number  (IAGP)
decreased susceptibility to bacterial infection  (IAGP)
decreased total fat pad weight  (IAGP)
enlarged spleen  (IAGP)
hepatic steatosis  (IAGP)
hypertension  (IAGP)
increased body weight  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating lipocalin 2 level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased epididymal fat pad weight  (IAGP)
increased fasting circulating glucose level  (IAGP)
increased interleukin-1 beta secretion  (IAGP)
increased susceptibility to autoimmune diabetes  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to colitis induced morbidity/mortality  (IAGP)
increased susceptibility to diet-induced obesity  (IAGP)
increased susceptibility to induced colitis  (IAGP)
increased susceptibility to induced pancreatitis  (IAGP)
increased systemic arterial blood pressure  (IAGP)
increased systemic arterial diastolic blood pressure  (IAGP)
increased systemic arterial systolic blood pressure  (IAGP)
increased total body fat amount  (IAGP)
increased total fat pad weight  (IAGP)
insulin resistance  (IAGP)
large intestinal inflammation  (IAGP)
lung inflammation  (IAGP)
obese  (IAGP)
polyphagia  (IAGP)
premature death  (IAGP)
rectal prolapse  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Whole-blood gene expression profiling in ankylosing spondylitis shows upregulation of toll-like receptor 4 and 5. Assassi S, etal., J Rheumatol. 2011 Jan;38(1):87-98. doi: 10.3899/jrheum.100469. Epub 2010 Oct 15.
2. TLR4 links podocytes with the innate immune system to mediate glomerular injury. Banas MC, etal., J Am Soc Nephrol. 2008 Apr;19(4):704-13. doi: 10.1681/ASN.2007040395. Epub 2008 Feb 6.
3. TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis. Blohmke CJ, etal., J Immunol. 2010 Dec 15;185(12):7731-8. Epub 2010 Nov 10.
4. Combinations of TLR and NOD2 ligands stimulate rat microglial P2X4R expression. Guo LH, etal., Biochem Biophys Res Commun. 2006 Oct 27;349(3):1156-62. Epub 2006 Sep 1.
5. Dysregulation of innate immune receptors on neutrophils in chronic granulomatous disease. Hartl D, etal., J Allergy Clin Immunol. 2008 Feb;121(2):375-382.e9. Epub 2007 Dec 26.
6. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. Hawn TR, etal., J Exp Med. 2003 Nov 17;198(10):1563-72.
7. Altered inflammatory responses in TLR5-deficient mice infected with Legionella pneumophila. Hawn TR, etal., J Immunol. 2007 Nov 15;179(10):6981-7.
8. Toll-like receptor polymorphisms and susceptibility to urinary tract infections in adult women. Hawn TR, etal., PLoS One. 2009 Jun 22;4(6):e5990. doi: 10.1371/journal.pone.0005990.
9. Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue. Kauppila JH, etal., Br J Cancer. 2013 Feb 19;108(3):638-43. doi: 10.1038/bjc.2012.589. Epub 2013 Jan 3.
10. TLR expression on neutrophils at the pulmonary site of infection: TLR1/TLR2-mediated up-regulation of TLR5 expression in cystic fibrosis lung disease. Koller B, etal., J Immunol. 2008 Aug 15;181(4):2753-63.
11. Pathogen recognition by the innate immune system. Kumar H, etal., Int Rev Immunol. 2011 Feb;30(1):16-34.
12. Changes in intestinal Toll-like receptors and cytokines precede histological injury in a rat model of necrotizing enterocolitis. Liu Y, etal., Am J Physiol Gastrointest Liver Physiol. 2009 Sep;297(3):G442-50. Epub 2009 Jul 16.
13. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
14. MGDs mouse GO annotations MGD data from the GO Consortium
15. Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia. Morris AE, etal., Am J Physiol Lung Cell Mol Physiol. 2009 Dec;297(6):L1112-9. Epub 2009 Oct 2.
16. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
17. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
18. Gene expression of Toll-like receptors and associated molecules induced by inflammatory stimuli in the primary alveolar macrophage. Oshikawa K and Sugiyama Y, Biochem Biophys Res Commun. 2003 Jun 6;305(3):649-55.
19. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
20. Effects of mannoprotein E1 in liquid diet on inflammatory response and TLR5 expression in the gut of rats infected by Salmonella typhimurium. Posadas SJ, etal., BMC Gastroenterol. 2010 Jun 8;10:58.
21. Mouse MP Annotation Import Pipeline RGD automated import pipeline
22. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
24. Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. Siezen CL, etal., Pediatr Infect Dis J. 2009 Apr;28(4):333-5.
25. Increased Toll-like Receptor-MyD88-NFκB-Proinflammatory neuroimmune signaling in the orbitofrontal cortex of humans with alcohol use disorder. Vetreno RP, etal., Alcohol Clin Exp Res. 2021 Sep;45(9):1747-1761. doi: 10.1111/acer.14669. Epub 2021 Aug 20.
26. Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis). Wiersinga WJ, etal., PLoS Med. 2007 Jul 31;4(7):e248.
27. Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide. Yu FS, etal., J Immunol. 2010 Jul 15;185(2):1142-9. Epub 2010 Jun 21.
28. Innate immune regulation of Serratia marcescens-induced corneal inflammation and infection. Zhou R, etal., Invest Ophthalmol Vis Sci. 2012 Oct 25;53(11):7382-8. doi: 10.1167/iovs.12-10238.
Additional References at PubMed
PMID:10349636   PMID:10756091   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12532263   PMID:12794153   PMID:15302888   PMID:15611268   PMID:15632166   PMID:15921521  
PMID:16026622   PMID:16033648   PMID:16141072   PMID:16141073   PMID:16602821   PMID:16648852   PMID:16648853   PMID:16688529   PMID:16829963   PMID:16891416   PMID:16984919   PMID:17082629  
PMID:17095659   PMID:17135446   PMID:17202381   PMID:17283206   PMID:17339488   PMID:17371986   PMID:17404249   PMID:17493681   PMID:17617608   PMID:17935074   PMID:18008007   PMID:18195036  
PMID:18378636   PMID:18499758   PMID:18516037   PMID:18523294   PMID:18566425   PMID:18641341   PMID:18798918   PMID:18799693   PMID:18988922   PMID:19152336   PMID:19357791   PMID:19382893  
PMID:19424969   PMID:19494277   PMID:19547909   PMID:19555720   PMID:19596770   PMID:19620771   PMID:19774646   PMID:19797072   PMID:19806220   PMID:19839009   PMID:19912257   PMID:19933833  
PMID:19950169   PMID:20164175   PMID:20196778   PMID:20203013   PMID:20452988   PMID:20566828   PMID:20668698   PMID:20826748   PMID:20844479   PMID:20855887   PMID:20953381   PMID:21057511  
PMID:21072873   PMID:21182074   PMID:21239713   PMID:21245274   PMID:21267068   PMID:21451112   PMID:21458307   PMID:21515787   PMID:21567398   PMID:21690093   PMID:21714724   PMID:21873635  
PMID:21918198   PMID:21985371   PMID:22250084   PMID:22250085   PMID:22297845   PMID:22306017   PMID:22306056   PMID:22307620   PMID:22323544   PMID:22323829   PMID:22466646   PMID:22545147  
PMID:22666391   PMID:22826298   PMID:22836022   PMID:22837383   PMID:22863420   PMID:23038756   PMID:23045613   PMID:23075849   PMID:23101627   PMID:23104900   PMID:23123736   PMID:23135279  
PMID:23152564   PMID:23630282   PMID:23897616   PMID:23977202   PMID:24042110   PMID:24048326   PMID:24064672   PMID:24091496   PMID:24102120   PMID:24412598   PMID:24442437   PMID:24487390  
PMID:24516564   PMID:24637670   PMID:24778236   PMID:24779433   PMID:24879439   PMID:24959742   PMID:25172014   PMID:25195514   PMID:25200955   PMID:25210785   PMID:25220212   PMID:25223833  
PMID:25232720   PMID:25283154   PMID:25378591   PMID:25402425   PMID:25418468   PMID:25533336   PMID:25563498   PMID:25575023   PMID:25681338   PMID:25731162   PMID:25757463   PMID:25797291  
PMID:25914934   PMID:26067589   PMID:26207027   PMID:26223660   PMID:26300483   PMID:26303344   PMID:26332085   PMID:26479925   PMID:26525535   PMID:26681840   PMID:26819479   PMID:26831100  
PMID:26845355   PMID:26907705   PMID:26914743   PMID:26950299   PMID:27001940   PMID:27060138   PMID:27159323   PMID:27288486   PMID:27391968   PMID:27546231   PMID:27606421   PMID:27621416  
PMID:27716507   PMID:27760316   PMID:27855208   PMID:27977701   PMID:28202909   PMID:28244143   PMID:28400473   PMID:28407032   PMID:28522600   PMID:28758900   PMID:28887442   PMID:28967901  
PMID:29062042   PMID:29097366   PMID:29589550   PMID:29590614   PMID:29617463   PMID:29734365   PMID:29746836   PMID:29920759   PMID:30089902   PMID:30097850   PMID:30170812   PMID:30340040  
PMID:30896848   PMID:30944865   PMID:31109950   PMID:31292433   PMID:31324538   PMID:31348811   PMID:31472954   PMID:31576678   PMID:31729371   PMID:31776239   PMID:31827095   PMID:31844047  
PMID:31852883   PMID:31866426   PMID:31972159   PMID:31989925   PMID:32027657   PMID:32060608   PMID:32150572   PMID:32200644   PMID:32325033   PMID:32559205   PMID:32820707   PMID:32849665  
PMID:32852795   PMID:32908007   PMID:32912327   PMID:33008952   PMID:33042267   PMID:33516921   PMID:33619092   PMID:34083551   PMID:34206257   PMID:34249474   PMID:34395439   PMID:34739338  
PMID:34840990   PMID:35028606   PMID:35304896   PMID:35793624   PMID:36157543   PMID:36635337   PMID:37219858   PMID:37433685   PMID:37742185   PMID:37898719   PMID:38167804   PMID:38482010  
PMID:38513665  


Genomics

Comparative Map Data
Tlr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,782,317 - 182,804,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,782,353 - 182,804,010 (+)EnsemblGRCm39 Ensembl
GRCm381182,954,752 - 182,976,044 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,954,788 - 182,976,044 (+)EnsemblGRCm38mm10GRCm38
MGSCv371184,884,919 - 184,906,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,884,919 - 184,906,170 (+)NCBIMGSCv36mm8
Celera1189,998,902 - 190,020,262 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map186.12NCBI
TLR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381223,109,404 - 223,143,248 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1223,109,404 - 223,143,292 (-)EnsemblGRCh38hg38GRCh38
GRCh371223,282,746 - 223,316,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,350,207 - 221,383,247 (-)NCBINCBI36Build 36hg18NCBI36
Celera1196,502,104 - 196,535,977 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1193,957,238 - 193,991,230 (-)NCBIHuRef
CHM1_11224,555,804 - 224,589,771 (-)NCBICHM1_1
T2T-CHM13v2.01222,347,318 - 222,381,267 (-)NCBIT2T-CHM13v2.0
Tlr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81397,166,430 - 97,190,642 (+)NCBIGRCr8
mRatBN7.21394,634,778 - 94,658,992 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,634,801 - 94,657,738 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1397,156,784 - 97,161,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,556,697 - 98,560,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01395,738,872 - 95,743,126 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,364,784 - 101,385,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,381,510 - 101,385,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013106,294,254 - 106,315,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41399,025,501 - 99,029,755 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11399,217,286 - 99,217,523 (+)NCBI
Celera1394,180,743 - 94,184,997 (+)NCBICelera
Cytogenetic Map13q26NCBI
Tlr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,556,523 - 1,559,093 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBIChiLan1.0ChiLan1.0
TLR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2126,171,713 - 26,204,781 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1126,127,751 - 26,160,814 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01198,787,046 - 198,819,537 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11203,797,720 - 203,831,605 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1203,798,767 - 203,801,343 (-)Ensemblpanpan1.1panPan2
TLR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13823,700,323 - 23,705,628 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3823,702,033 - 23,705,314 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3823,729,352 - 23,731,928 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03823,873,004 - 23,878,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3823,874,719 - 23,878,000 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13823,620,126 - 23,622,702 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03824,170,412 - 24,172,988 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03824,572,699 - 24,575,275 (+)NCBIUU_Cfam_GSD_1.0
Tlr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934454,334,832 - 54,363,906 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936526383,418 - 401,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936526383,490 - 387,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1019,387,666 - 19,410,024 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11019,387,666 - 19,410,024 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21021,886,309 - 21,888,880 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,418,895 - 6,440,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,437,638 - 6,440,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660556,652,060 - 6,685,032 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248355,500,461 - 5,503,034 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248355,495,723 - 5,503,462 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tlr5
1296 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:309
Count of miRNA genes:248
Interacting mature miRNAs:260
Transcripts:ENSMUST00000110997
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039528Ccc3_mcolitis susceptibility in the Collaborative Cross 3 (mouse)13680142195051546Mouse
4141245Cq2_mcholesterol QTL 2 (mouse)Not determined1157456299191456436Mouse
4141244Bmd5c_mbone mineral density 5c (mouse)Not determined155526796189526897Mouse
1558802Skmw6_mskeletal muscle weight 6 (mouse)Not determined1167954584195154279Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163854690189303617Mouse
13464138Hdlq107_mHDL QTL 107 (mouse)1152132744186132744Mouse
1301652Cpfd2_mcerebellum pattern fissures (mouse)Not determined1172303451195154279Mouse
12790987Tgl5_mtriglyceride 5 (mouse)1160097157194097157Mouse
13824984Twq5_mtestis weight QTL 5 (mouse)13069992184732197Mouse
4142389Scfr1_mstem cell frequency regulator 1 (mouse)Not determined171632048189303617Mouse
1300888Berr1_mberghei resistance locus 1 (mouse)Not determined1164143227190534272Mouse
12790988Phdlc5_mplasma HDL cholesterol 5 (mouse)9160097157194097157Mouse
1301251Scc3_mcolon tumor susceptibility 3 (mouse)Not determined1168213823195154279Mouse
1301122Cd8mts1_mCD8 T memory cell subset 1 (mouse)Not determined1155831765189831892Mouse
1301632Bw8q1_mbody weight at 8 weeks QTL 1 (mouse)Not determined1161201261195154279Mouse
4141483Femwf7_mfemur work to failure 7 (mouse)Not determined167462514195154279Mouse
1302023Orch4_mautoimmune orchitis resistance 4 (mouse)Not determined1175211318195154279Mouse
1301385Radpf2_mradiation pulmonary fibrosis 2 (mouse)Not determined1147125258182873798Mouse
1300745Gvhd1_mgraft-versus-host disease 1 (mouse)Not determined1157456299191456436Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1103933405191225397Mouse
4141346Skmw12_mskeletal muscle weight 12 (mouse)Not determined150756737184756922Mouse
1301134Bmd1_mbone mineral density 1 (mouse)Not determined1156602037189303617Mouse
1302158Fembrs5_mfemur breaking strength 5 (mouse)Not determined1167462514195154279Mouse
1301132Mors1_mmodifier of obesity related sterility 1 (mouse)Not determined1170379500195154279Mouse
1357620Aaj1_manxiety in A/J 1 (mouse)Not determined1180832317191851043Mouse
1357493Lgaq3_mlate growth adjusted QTL 3 (mouse)Not determined1150193673188359312Mouse
11251722Ewc1_methanol withdrawal and consumption 1 (mouse)1152132744186132744Mouse
10043963Obq25_mobesity QTL 25 (mouse)Not determined1154410512188410512Mouse
1301431Pcho1_mplasma cholesterol 1 (mouse)Not determined1159262573193262693Mouse
1357618Splq5_mspleen weight QTL 5 (mouse)Not determined1150193673188359312Mouse
1301301Sle1_msystemic lupus erythmatosus susceptibility 1 (mouse)Not determined1152038741186038913Mouse
12904936Edlmmq1_mextensor digitorum longus muscle mass QTL 1 (mouse)1155002940189002940Mouse
1301565Mnotch_mmodifier of Notch (mouse)Not determined1157456299191456436Mouse
1301309Emo1_memotionality 1 (mouse)Not determined1162977097185994196Mouse
1357732Tbbmd1_mtotal body bone mineral density 1 (mouse)Not determined1171983110195154279Mouse
1301025Lbw7_mlupus NZB x NZW 7 (mouse)Not determined1152038741186038913Mouse
10412074Nhdlt1_mnon-HDL cholesterol and triglyceride levels 1 (mouse)Not determined1153675990187676105Mouse
12904944Tammq1_mtibialis anterior muscle mass QTL 1 (mouse)1155002940189002940Mouse
1357485Lgq4_mlate growth QTL 4 (mouse)Not determined1150193673188359312Mouse
12904957Gmmq1_mgastrocnemius muscle mass QTL 1 (mouse)1155002940189002940Mouse
11532690Sluc37_msusceptibility to lung cancer 37 (mouse)1175468817194111528Mouse
1301932Ssta2_msusceptibility to Salmonella typhimurium antigens 2 (mouse)Not determined1155716221189716369Mouse
1301202Yaa4_mY-linked autoimmune acceleration 4 (mouse)Not determined1158468817192468938Mouse
10054490Opefa_mopen field activity (mouse)Not determined1153712853187712853Mouse
1300823Ath9_matherosclerosis 9 (mouse)Not determined1160112768194112883Mouse
1301333Mop3_mmorphine preference 3 (mouse)Not determined1167756737189303617Mouse
1300948Fglu2_mfasting glucose 2 (mouse)Not determined1157456299191456436Mouse
1301339Hdlq15_mHDL QTL 15 (mouse)Not determined1165873675195154279Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145783900189303617Mouse
11059556Lmr20b_mleishmaniasis resistance 20b (mouse)1158468817192468938Mouse
4141554Cfmq1_mcystic fibrosis modifier QTL 1 (mouse)Not determined1152038741186038913Mouse
11059557Lmr20a_mleishmaniasis resistance 20a (mouse)1158468817192468938Mouse
11059558Lmr20c_mleishmaniasis resistance 20c (mouse)1158468817192468938Mouse
10043863Swrl5_mSWR lupus locus 5 (mouse)Not determined1172303451195154279Mouse
1301596Elnt_mescape latencies during navigation task (mouse)Not determined1162145207194111528Mouse
11049575Lmr8b_mleishmaniasis resistance 8b (mouse)1172303451195154279Mouse
4141165Bglu3_mblood glucose level 3 (mouse)Not determined155831765189831892Mouse
12792983Liq1_mlimb inflammation QTL 1 (mouse)1167586086191225397Mouse
1357889Lprq3_mlipoprotein QTL 3 (mouse)Not determined1152038741186038913Mouse
1301189Lmr8_mleishmaniasis resistance 8 (mouse)Not determined1156602037189303617Mouse
4142182Shali5_msurvival time to hyperoxic acute lung injury 5 (mouse)Not determined155582237185994196Mouse
10766456Sle21_msystematic lupus erythematosus susceptibility 21 (mouse)1155831765189831892Mouse
10402498Lmr20_mleishmaniasis resistance 20 (mouse)Not determined1158468817192468938Mouse
1301619Cafq1_mcaffeine metabolism QTL 1 (mouse)Not determined1155716221189716369Mouse
4141149Hbnr4_mHeligmosomoides bakeri nematode resistance 4 (mouse)Not determined147125258188983224Mouse
1300727Mptp1_mMPTP sensitivity 1 (mouse)Not determined1171632048192681050Mouse
10054271Nba9_mNew Zealand Black autoimmunity 9 (mouse)Not determined1155525623189527533Mouse
11081167Tir8_mtrypanosome infection response 8 (mouse)1155716221189716369Mouse
10054270Nba10_mNew Zealand Black autoimmunity 10 (mouse)Not determined1152794822186438620Mouse
1302132Pbw1_mpentobarbital withdrawal QTL 1 (mouse)Not determined1155831765189831892Mouse
1559024Zit1_mzinc induced tolerance 1 (mouse)Not determined1167462514195154279Mouse
1357692Axtq1_manxiety QTL 1 (mouse)Not determined1180832317191851043Mouse
12880429V25Dq1_mvitamin D inactive form serum level QTL 1 (mouse)1172632197195154279Mouse
12880426V25Dq2_mvitamin D inactive form serum level QTL 2 (mouse)1172532197195154279Mouse
1300732Melm2_mmelanoma modifier 2 (mouse)Not determined1157456299191456436Mouse
4142159Nba2_mNew Zealand Black autoimmunity 2 (mouse)Not determined151835111185835280Mouse
1301602Bslm4_mbasal locomotor activity 4 (mouse)Not determined1157456299191456436Mouse
1301216Cbm1_mcerebellum weight 1 (mouse)Not determined1157456299191456436Mouse
1301866Cplaq3_mcircadian period of locomotor activity 3 (mouse)Not determined1155721528189722608Mouse
1300842Sle9_msystematic lupus erythematosus susceptibility 9 (mouse)Not determined1158468817192468938Mouse
1300969Sluc5_msusceptibility to lung cancer 5 (mouse)Not determined1151186243185186402Mouse
1301614Cgnz1_mchronic glomerulonephritis in NZM 1 (mouse)Not determined1152038741186038913Mouse

Markers in Region
Tlr5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371184,904,681 - 184,904,874UniSTSGRCm37
Celera1190,018,750 - 190,018,943UniSTS
Cytogenetic Map1H5UniSTS
cM Map198.0UniSTS
PMC133006P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,973,684 - 182,974,082UniSTSGRCm38
MGSCv371184,903,815 - 184,904,213UniSTSGRCm37
Celera1190,017,884 - 190,018,282UniSTS
Cytogenetic Map1H5UniSTS
cM Map198.0UniSTS
PMC187346P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,973,990 - 182,974,376UniSTSGRCm38
MGSCv371184,904,121 - 184,904,507UniSTSGRCm37
Celera1190,018,190 - 190,018,576UniSTS
Cytogenetic Map1H5UniSTS
cM Map198.0UniSTS
Tlr5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,973,317 - 182,973,916UniSTSGRCm38
MGSCv371184,903,448 - 184,904,047UniSTSGRCm37
Celera1190,017,517 - 190,018,116UniSTS
Cytogenetic Map1H5UniSTS
Tlr5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Celera1190,020,083 - 190,020,281UniSTS
Cytogenetic Map1H5UniSTS
cM Map198.0UniSTS
Tlr5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H5UniSTS
cM Map198.0UniSTS
Tlr5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1H5UniSTS
cM Map198.0UniSTS
Tlr5  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381182,974,550 - 182,974,743UniSTSGRCm38
MGSCv371184,904,681 - 184,904,874UniSTSGRCm37
Celera1190,018,750 - 190,018,943UniSTS
Cytogenetic Map1H5UniSTS
cM Map198.0UniSTS


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_016928 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321698 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321700 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321701 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321702 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321703 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017321704 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC170917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF186107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI118722 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK036842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125240 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466555 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ414410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ414411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FO082331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSMUST00000110997   ⟹   ENSMUSP00000106625
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1182,954,788 - 182,976,044 (+)Ensembl
Ensembl Acc Id: ENSMUST00000191820   ⟹   ENSMUSP00000141458
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1182,799,742 - 182,804,010 (+)Ensembl
GRCm38.p6 Ensembl1182,972,177 - 182,975,994 (+)Ensembl
Ensembl Acc Id: ENSMUST00000193539
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1182,782,387 - 182,797,825 (+)Ensembl
GRCm38.p6 Ensembl1182,954,822 - 182,970,260 (+)Ensembl
Ensembl Acc Id: ENSMUST00000193687   ⟹   ENSMUSP00000141318
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1182,782,353 - 182,803,319 (+)Ensembl
GRCm38.p6 Ensembl1182,954,788 - 182,975,692 (+)Ensembl
Ensembl Acc Id: ENSMUST00000195614
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1182,782,393 - 182,797,589 (+)Ensembl
GRCm38.p6 Ensembl1182,954,828 - 182,970,024 (+)Ensembl
RefSeq Acc Id: NM_016928   ⟹   NP_058624
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391182,782,361 - 182,804,010 (+)NCBI
GRCm381182,954,788 - 182,976,044 (+)NCBI
MGSCv371184,884,919 - 184,906,175 (+)RGD
Celera1189,998,902 - 190,020,262 (+)RGD
cM Map1 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017321697   ⟹   XP_017177186
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391182,782,332 - 182,804,010 (+)NCBI
GRCm381182,954,766 - 182,976,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017321698   ⟹   XP_017177187
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391182,782,317 - 182,804,010 (+)NCBI
GRCm381182,954,752 - 182,976,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017321699   ⟹   XP_017177188
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391182,782,330 - 182,804,010 (+)NCBI
GRCm381182,954,765 - 182,976,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017321700   ⟹   XP_017177189
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391182,782,331 - 182,804,010 (+)NCBI
GRCm381182,954,765 - 182,976,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017321701   ⟹   XP_017177190
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391182,782,492 - 182,804,010 (+)NCBI
GRCm381182,955,047 - 182,976,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017321702   ⟹   XP_017177191
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391182,783,639 - 182,804,010 (+)NCBI
GRCm381182,956,067 - 182,976,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017321703   ⟹   XP_017177192
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391182,782,318 - 182,804,010 (+)NCBI
GRCm381182,954,752 - 182,976,038 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017321704   ⟹   XP_017177193
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391182,782,492 - 182,804,010 (+)NCBI
GRCm381182,955,047 - 182,976,038 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058624   ⟸   NM_016928
- Peptide Label: precursor
- UniProtKB: Q05AH3 (UniProtKB/TrEMBL),   Q1ZZX0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177187   ⟸   XM_017321698
- Peptide Label: isoform X1
- UniProtKB: A0A0A6YVY4 (UniProtKB/TrEMBL),   Q1ZZX0 (UniProtKB/TrEMBL),   Q8CB40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177192   ⟸   XM_017321703
- Peptide Label: isoform X1
- UniProtKB: A0A0A6YVY4 (UniProtKB/TrEMBL),   Q1ZZX0 (UniProtKB/TrEMBL),   Q8CB40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177188   ⟸   XM_017321699
- Peptide Label: isoform X1
- UniProtKB: A0A0A6YVY4 (UniProtKB/TrEMBL),   Q1ZZX0 (UniProtKB/TrEMBL),   Q8CB40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177189   ⟸   XM_017321700
- Peptide Label: isoform X1
- UniProtKB: A0A0A6YVY4 (UniProtKB/TrEMBL),   Q1ZZX0 (UniProtKB/TrEMBL),   Q8CB40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177186   ⟸   XM_017321697
- Peptide Label: isoform X1
- UniProtKB: A0A0A6YVY4 (UniProtKB/TrEMBL),   Q1ZZX0 (UniProtKB/TrEMBL),   Q8CB40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177190   ⟸   XM_017321701
- Peptide Label: isoform X1
- UniProtKB: A0A0A6YVY4 (UniProtKB/TrEMBL),   Q1ZZX0 (UniProtKB/TrEMBL),   Q8CB40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177193   ⟸   XM_017321704
- Peptide Label: isoform X1
- UniProtKB: A0A0A6YVY4 (UniProtKB/TrEMBL),   Q1ZZX0 (UniProtKB/TrEMBL),   Q8CB40 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017177191   ⟸   XM_017321702
- Peptide Label: isoform X1
- UniProtKB: A0A0A6YVY4 (UniProtKB/TrEMBL),   Q1ZZX0 (UniProtKB/TrEMBL),   Q8CB40 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSMUSP00000106625   ⟸   ENSMUST00000110997
Ensembl Acc Id: ENSMUSP00000141458   ⟸   ENSMUST00000191820
Ensembl Acc Id: ENSMUSP00000141318   ⟸   ENSMUST00000193687
Protein Domains
LRRCT   TIR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLF7-F1-model_v2 AlphaFold Q9JLF7 1-859 view protein structure

Promoters
RGD ID:6875982
Promoter ID:EPDNEW_M1442
Type:multiple initiation site
Name:Tlr5_1
Description:Mus musculus toll-like receptor 5 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381182,954,802 - 182,954,862EPDNEW
RGD ID:6818585
Promoter ID:MM_KWN:3195
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:NM_016928,   NM_016928_TLR5
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361184,884,776 - 184,885,276 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1858171 AgrOrtholog
Ensembl Genes ENSMUSG00000045497
  ENSMUSG00000079164 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000191820 ENTREZGENE
  ENSMUST00000191820.3 UniProtKB/TrEMBL
  ENSMUST00000193687 ENTREZGENE
  ENSMUST00000193687.7 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:53791 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1858171 ENTREZGENE
NCBI Gene 53791 ENTREZGENE
PANTHER PTHR24365 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24365:SF525 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Tlr5 PhenoGen
PIRSF Toll-like_receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52200 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0A6YVY4 ENTREZGENE, UniProtKB/TrEMBL
  Q05AH3 ENTREZGENE, UniProtKB/TrEMBL
  Q1ZZX0 ENTREZGENE
  Q8CB40 ENTREZGENE, UniProtKB/TrEMBL
  Q9JLF7 ENTREZGENE, UniProtKB/Swiss-Prot