RGD Reference Report - Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes. - Rat Genome Database

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Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.

Authors: Siezen, CL  Bont, L  Hodemaekers, HM  Ermers, MJ  Doornbos, G  Van't Slot, R  Wijmenga, C  Houwelingen, HC  Kimpen, JL  Kimman, TG  Hoebee, B  Janssen, R 
Citation: Siezen CL, etal., Pediatr Infect Dis J. 2009 Apr;28(4):333-5.
RGD ID: 4142862
Pubmed: (View Article at PubMed) PMID:19258923
DOI: Full-text: DOI:10.1097/INF.0b013e31818e2aa9

Prematurity is a risk factor for severe respiratory syncytial virus bronchiolitis. We show that genetic factors in innate immune genes (IFNA13, IFNAR2, STAT2, IL27, NFKBIA, C3, IL1RN, TLR5), in innate and adaptive immunity (IFNG), and in airway remodeling genes (ADAM33 and TGFBR1), affect disease susceptibility to a different extent in preterm children, born with underdeveloped lungs, than in term children.



Disease Annotations    
Viral Bronchiolitis  (IAGP,ISO)

Objects Annotated

Genes (Rattus norvegicus)
Adam33  (ADAM metallopeptidase domain 33)
C3  (complement C3)
Il1rn  (interleukin 1 receptor antagonist)
Tlr5  (toll-like receptor 5)

Genes (Mus musculus)
Adam33  (a disintegrin and metallopeptidase domain 33)
C3  (complement component 3)
Il1rn  (interleukin 1 receptor antagonist)
Tlr5  (toll-like receptor 5)

Genes (Homo sapiens)
ADAM33  (ADAM metallopeptidase domain 33)
C3  (complement C3)
IL1RN  (interleukin 1 receptor antagonist)
TLR5  (toll like receptor 5)


Additional Information