TLR5 (toll like receptor 5) - Rat Genome Database

Name: TLR5
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: TLR5 (toll like receptor 5) Canis lupus familiaris

Analyze

Symbol:

TLR5

Name:

toll like receptor 5

RGD ID:

12316177

Description:

ENCODES a protein that exhibits interleukin-1 receptor binding (ortholog); pattern recognition receptor activity (ortholog); INVOLVED IN cellular response to lipopolysaccharide (ortholog); cellular response to mechanical stimulus (ortholog); male gonad development (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); ankylosing spondylitis (ortholog); Bacterial Keratitis (ortholog); FOUND IN membrane (inferred)

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

toll-like receptor 5

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	TLR5 (toll like receptor 5)	HGNC	HomoloGene, NCBI
Mus musculus (house mouse):	Tlr5 (toll-like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Tlr5 (toll-like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Tlr5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	TLR5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Tlr5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	TLR5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	TLR5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Tlr5 (toll like receptor 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

CanFam3.1 - Dog CanFam3.1 Assembly

Position:

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	23,700,323 - 23,705,628 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	23,702,033 - 23,705,314 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	23,729,352 - 23,731,928 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	23,873,004 - 23,878,847 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	23,874,719 - 23,878,000 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	23,620,126 - 23,622,702 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	24,170,412 - 24,172,988 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	24,572,699 - 24,575,275 (+)	NCBI		UU_Cfam_GSD_1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adult respiratory distress syndrome (ISO)

ankylosing spondylitis (ISO)

Bacterial Keratitis (ISO)

bacterial pneumonia (ISO)

Chemical and Drug Induced Liver Injury (ISO)

chronic granulomatous disease (ISO)

cystic fibrosis (ISO)

cystitis (ISO)

gastrointestinal stromal tumor (ISO)

genetic disease (ISO)

Hyperammonemia (ISO)

Legionnaires' disease (ISO)

melioidosis (ISO)

membranoproliferative glomerulonephritis (ISO)

parathyroid carcinoma (ISO)

perinatal necrotizing enterocolitis (ISO)

Prostatic Neoplasms (ISO)

Pseudomonas Infections (ISO)

Salmonella Infections, Animal (ISO)

systemic lupus erythematosus (ISO)

Tongue Neoplasms (ISO)

Viral Bronchiolitis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to lipopolysaccharide (ISO)

cellular response to mechanical stimulus (ISO)

defense response (IEA)

immune response (IEA)

immune system process (IEA)

inflammatory response (IEA)

innate immune response (IEA)

male gonad development (ISO)

positive regulation of interleukin-8 production (ISO)

positive regulation of nitric oxide biosynthetic process (ISO)

signal transduction (IEA)

toll-like receptor 5 signaling pathway (ISO)

toll-like receptor signaling pathway (IEA)

Cellular Component

membrane (IEA)

Molecular Function

interleukin-1 receptor binding (ISO)

pattern recognition receptor activity (ISO)

protein binding (ISO)

signaling receptor activity (IEA)

transmembrane signaling receptor activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

Toll-like receptor signaling pathway (ISO)

References

Additional References at PubMed

PMID:19254256	PMID:21203467	PMID:21623734	PMID:22279566	PMID:22301074	PMID:25728812	PMID:28738011	PMID:30032202	PMID:30502908

Genomics

Comparative Map Data

TLR5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	38	23,700,323 - 23,705,628 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	38	23,702,033 - 23,705,314 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	38	23,729,352 - 23,731,928 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	38	23,873,004 - 23,878,847 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	38	23,874,719 - 23,878,000 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	38	23,620,126 - 23,622,702 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	38	24,170,412 - 24,172,988 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	38	24,572,699 - 24,575,275 (+)	NCBI		UU_Cfam_GSD_1.0

TLR5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	1	223,109,404 - 223,143,248 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	1	223,109,404 - 223,143,248 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	1	223,282,746 - 223,316,590 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	1	221,350,207 - 221,383,247 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	1	196,502,104 - 196,535,977 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI
HuRef	1	193,957,238 - 193,991,230 (-)	NCBI		HuRef
CHM1_1	1	224,555,804 - 224,589,771 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	1	222,347,318 - 222,381,267 (-)	NCBI		T2T-CHM13v2.0

Tlr5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	1	182,782,317 - 182,804,010 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	1	182,782,353 - 182,804,010 (+)	Ensembl		GRCm39 Ensembl
GRCm38	1	182,954,752 - 182,976,044 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	1	182,954,788 - 182,976,044 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	1	184,884,919 - 184,906,175 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	1	184,884,919 - 184,906,170 (+)	NCBI		MGSCv36	mm8
Celera	1	189,998,902 - 190,020,262 (+)	NCBI		Celera
Cytogenetic Map	1	H5	NCBI
cM Map	1	86.12	NCBI

Tlr5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	13	97,166,430 - 97,190,642 (+)	NCBI		GRCr8
mRatBN7.2	13	94,634,778 - 94,658,992 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	13	94,634,801 - 94,657,738 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	13	97,156,784 - 97,161,038 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	13	98,556,697 - 98,560,951 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	13	95,738,872 - 95,743,126 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	13	101,364,784 - 101,385,764 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	13	101,381,510 - 101,385,764 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	13	106,294,254 - 106,315,238 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	13	99,025,501 - 99,029,755 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	13	99,217,286 - 99,217,523 (+)	NCBI
Celera	13	94,180,743 - 94,184,997 (+)	NCBI		Celera
Cytogenetic Map	13	q26	NCBI

Tlr5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955520	1,556,523 - 1,559,093 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955520	1,544,840 - 1,562,081 (+)	NCBI	ChiLan1.0	ChiLan1.0

TLR5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	1	26,171,713 - 26,204,781 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	1	26,127,751 - 26,160,814 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	1	198,787,046 - 198,819,537 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	1	203,797,720 - 203,831,605 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	1	203,798,767 - 203,801,343 (-)	Ensembl	panpan1.1		panPan2

Tlr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	54,334,832 - 54,363,906 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936526	383,418 - 401,552 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936526	383,490 - 387,007 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TLR5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	10	19,387,666 - 19,410,024 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	10	19,387,666 - 19,410,024 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	10	21,886,309 - 21,888,880 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TLR5
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	25	6,418,895 - 6,440,433 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	25	6,437,638 - 6,440,211 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666055	6,652,060 - 6,685,032 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tlr5
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624835	5,500,461 - 5,503,034 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624835	5,495,723 - 5,503,462 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in TLR5
196 total Variants

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	reproductive system	respiratory system	adipose tissue
High
Medium
Low	4		21	6	5	6	5		12	8	10	5
Below cutoff	1	5	1		1		1	6				1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001197176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_005640757	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_022415290	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038448133	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_038448134	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAEX04000038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU551146	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU682446	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAHUQ010000364	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAQRD010000087	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAAUVH010000370	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX758532	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX758533	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX758534	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KX758535	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	REHQ01000038	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCAFT00000018059 ⟹ ENSCAFP00000016726

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1 Ensembl	38	23,702,033 - 23,705,314 (+)	Ensembl

RefSeq Acc Id:

ENSCAFT00845033817 ⟹ ENSCAFP00845026464

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0 Ensembl	38	23,874,719 - 23,878,000 (+)	Ensembl

RefSeq Acc Id:

NM_001197176 ⟹ NP_001184105

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
CanFam3.1	38	23,702,738 - 23,705,314 (+)	NCBI
Dog10K_Boxer_Tasha	38	23,729,352 - 23,731,928 (+)	NCBI
ROS_Cfam_1.0	38	23,875,424 - 23,878,000 (+)	NCBI
UMICH_Zoey_3.1	38	23,620,126 - 23,622,702 (+)	NCBI
UNSW_CanFamBas_1.0	38	24,170,412 - 24,172,988 (+)	NCBI
UU_Cfam_GSD_1.0	38	24,572,699 - 24,575,275 (+)	NCBI

Sequence:

show sequence

ATGGGCCGCCAGCTGGGCCGCGCACTGGGGCTGCTGCTTGTGGCCGGCGCCGTGGCCGCGGCAT
CCTGCTGCGTGGCTGACGGCCGGAGGGCCCTGTACCGCTCCTGCAACCTCAGCCAGGTGCCCCC
GGTCCCCAGCACCACCGAGATCCTCCTGCTGAGCTTCAACTACATCCGGGCCGTCACCCGCGCC
TCGTTCCCCCTCCTGGAGCGGCTGCAGCTGCTGGAGCTGGGGACGCAGCAGACGCCCTTCAGCG
TCGACAGAGAAGCCTTCAGGAACCTGCCCAACCTGCGCACCCTGGACCTGGGCAACAGCCGGGT
GGATTTCCTGCATCCCGACGCCTTCCAGGGGCTGCCCCACCTGCAGGAACTCCGGCTGTTCGCC
TGTGGCCTCTCCGACGTCGTGTTGACAGACGGTTATTTCAGAAACCTGGGGGCTTTGTCGCGCC
TGGACCTGTCCAAAAATCAGATTGGGAGCCTCGAGCTTCACGCCTCCTTCCGGGAGCTGGGTTC
CCTGAGGTCCGTGGACTTTTCCCTCAACCGGATCCCGGCTGCGTGTGAGCAGGGGCTCAGGCCC
CTGCAGGGCAAGGCGCTCTCCCTTCTGAACCTCGCGGCCAATGGCCTGTACAGCCGGGCCCCCG
TGGACTGGGGGCGGTGCGGGAACCCGTTCAGGAACGTGGTCCTGGAGACCCTGGACGTGTCTAA
CAACGGCTGGACCGCAGACGTCACGGGCAACGTCACCAGGGCCATCGGTGGGAGCCAGATCTCC
TCCTTGGTGCTCGCCCACCACATCATGGGGCAGGGGTTTGGCTTCCGGAACATCCGGGACCCTG
ACCGGAGCACGTTCGCGGGGCTGGCCGGGAGCTCGGTGCTGCGGCTGGATCTGTCGCACGGCTT
CGTCTTCTCCCTGAACGCCCGACTGTTCGAGGTGCTCGGGGACCTGAAGCTCCTGGACCTCGCC
CACAACAAGATCAACAGGATCGCGGGAGAAGCGTTTCACGGCCTCGGCAGCGTCCAGGTTCTCA
ACCTGTCGCACAATCTCCTGGGCGAGCTCTATGACTCTGACTTCTCGGGGCTCGCGGAGGTCGC
CTACATTGACCTGCAGCACAATCACATCGGGATCATCCAGGACCAGACGTTCAGATTCCTGGGG
GCGCTTCGGACCCTGGATCTCCGCGACAACGCCCTCAAAACCGTTTCCTTCGTGCCCAGCATAG
ACACCATCTTCCTGGGCAACAACAAGCTGGAGACCGTGTCCCACATGGACCTCACAGCCAGCTT
CCTGGAGCTGTCGGACAACAGGCTGGAGGACCTGGGCGACCTCTACTCGCTCCTCCGGGTCCCT
GCCCTGCAGGTCCTCATCCTCAACCGCAACCGCCTGTCCGCGTGCCGTGGCGGACACGGCCCCA
CGGGCAGCGTCGGCCCAGAGAGGCTCTTCCTCGGGAGCAACATGCTGCAGCTGGCCTGGGAGAC
CGGGCGGTGCTGGGACGTGTTCCGGGGGCTGCCCCGGCTCCGGGTGCTGCACCTGAACCACAAC
TACCTGGCCGCCCTCCCGCCGGGGCTGCTGCGGGACCTCACGGCGCTGAGGGGCCTCGACCTGA
GCGCCAACAGGCTGAGCACGCTGTCCCGGGGCGACCTGCCTGCTGCCTTGGAGGTGCTGGATGT
GTCCAGGAACCAGCTCCTGTCCCTGGACCCCGGGCTGCTCGCCCCGCTCAGAGCCGTGGACCTA
ACGCACAACAAGTTCATCTGCGGCTGCGAGCTCCGTCCCTTGGTGAGGTGGCTCAACCGGACCA
ACGTCACTGTGTTCGGGTCCCGCGCAGACGTGCGCTGCGCCTACCCCAGCTTGCTTGCGGGGAC
GCCCCTGTCCTCTGTCTCCATGGAGGGCTGTGACGACGAGGAGGCCCTGCGGACCCTCACGTTC
TCCCTCTTCATCTTCTCCACCGTCGGGGTCACGCTGTTCCTCCTGGCCGTCCTCGTGGCCGCCA
AGCTCCGGGGCCTTTGCTTCCTCTGTTACAAGGCGGCCCGGCGCCTCCTGCCTGCGGGGCCCGC
CGAGGACGGAGCGCCCGACGCGTACCAGTACGACGCCTACCTGTGCTTCAGCGGCAGAGACTTC
GAGTGGGTGCAGCGCGCGCTGCTCAGGCACCTGGACGCTCAGTACAGCTCCCGAAACAGGCTGA
ACCTGTGCTTCGAGGAGAGGGACTTCGTCCCGGGGCGGGAGCACATCGCCAACATCCAGGACGC
CGTGTGGAGCAGCCGCAAGGTGGTCTGTCTGGTGAGCAGGCACTTCCTCCGCGACGGGTGGTGC
CTGGAGGCCTTCGCGGCCGCGCGGAGCCGCTGCGCGTCCCACCTGGACGGCGCCCTCGTCCTGG
TGGTCGTGGGCTCCCTGTCGCAGTACCAGCTGAGGAGGCACCCGGCCATCGGGGGCTTCGTGCG
GCAGCGCCGGTACTTGAGGTGGCCCGAGGATCTGCAGGACGTGGGCTGGTTCCTGGACACGCTC
TCCCGACACATCCTGCAGGAGCAGAGGGGCGCGCGCGGGGATGGCGGCATCCCGCTGCGCACCG
TGGCGGCCGTCGCCTAG

hide sequence

RefSeq Acc Id:

XM_038448133 ⟹ XP_038304061

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	38	23,873,004 - 23,878,847 (+)	NCBI

RefSeq Acc Id:

XM_038448134 ⟹ XP_038304062

Type:

CODING

Position:

Dog Assembly	Chr	Position (strand)	Source
ROS_Cfam_1.0	38	23,875,132 - 23,878,847 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001184105	(Get FASTA)	NCBI Sequence Viewer
	XP_038304061	(Get FASTA)	NCBI Sequence Viewer
	XP_038304062	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	ACB41374	(Get FASTA)	NCBI Sequence Viewer
	ACG60715	(Get FASTA)	NCBI Sequence Viewer
	APX39079	(Get FASTA)	NCBI Sequence Viewer
	APX39080	(Get FASTA)	NCBI Sequence Viewer
	APX39081	(Get FASTA)	NCBI Sequence Viewer
	APX39082	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCAFP00000016726.5
	ENSCAFP00845026464
	ENSCAFP00845026464.1

RefSeq Acc Id:	NP_001184105 ⟸ NM_001197176
- Peptide Label:	precursor
- UniProtKB:	B2CW36 (UniProtKB/TrEMBL), C3S7P1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MGRQLGRALGLLLVAGAVAAASCCVADGRRALYRSCNLSQVPPVPSTTEILLLSFNYIRAVTRA SFPLLERLQLLELGTQQTPFSVDREAFRNLPNLRTLDLGNSRVDFLHPDAFQGLPHLQELRLFA CGLSDVVLTDGYFRNLGALSRLDLSKNQIGSLELHASFRELGSLRSVDFSLNRIPAACEQGLRP LQGKALSLLNLAANGLYSRAPVDWGRCGNPFRNVVLETLDVSNNGWTADVTGNVTRAIGGSQIS SLVLAHHIMGQGFGFRNIRDPDRSTFAGLAGSSVLRLDLSHGFVFSLNARLFEVLGDLKLLDLA HNKINRIAGEAFHGLGSVQVLNLSHNLLGELYDSDFSGLAEVAYIDLQHNHIGIIQDQTFRFLG ALRTLDLRDNALKTVSFVPSIDTIFLGNNKLETVSHMDLTASFLELSDNRLEDLGDLYSLLRVP ALQVLILNRNRLSACRGGHGPTGSVGPERLFLGSNMLQLAWETGRCWDVFRGLPRLRVLHLNHN YLAALPPGLLRDLTALRGLDLSANRLSTLSRGDLPAALEVLDVSRNQLLSLDPGLLAPLRAVDL THNKFICGCELRPLVRWLNRTNVTVFGSRADVRCAYPSLLAGTPLSSVSMEGCDDEEALRTLTF SLFIFSTVGVTLFLLAVLVAAKLRGLCFLCYKAARRLLPAGPAEDGAPDAYQYDAYLCFSGRDF EWVQRALLRHLDAQYSSRNRLNLCFEERDFVPGREHIANIQDAVWSSRKVVCLVSRHFLRDGWC LEAFAAARSRCASHLDGALVLVVVGSLSQYQLRRHPAIGGFVRQRRYLRWPEDLQDVGWFLDTL SRHILQEQRGARGDGGIPLRTVAAVA hide sequence

RefSeq Acc Id:

ENSCAFP00000016726 ⟸ ENSCAFT00000018059

RefSeq Acc Id:	XP_038304061 ⟸ XM_038448133
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I3NY74 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038304062 ⟸ XM_038448134
- Peptide Label:	isoform X2
- UniProtKB:	C3S7P1 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSCAFP00845026464 ⟸ ENSCAFT00845033817

Protein Domains

TIR

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCAFG00000011368	Ensembl, UniProtKB/TrEMBL
	ENSCAFG00845019169	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCAFT00000018059.5	UniProtKB/TrEMBL
	ENSCAFT00845033817	ENTREZGENE
	ENSCAFT00845033817.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.10140	UniProtKB/TrEMBL
	3.80.10.10	UniProtKB/TrEMBL
InterPro	Cys-rich_flank_reg_C	UniProtKB/TrEMBL
	Leu-rich_rpt	UniProtKB/TrEMBL
	Leu-rich_rpt_typical-subtyp	UniProtKB/TrEMBL
	LRR_dom_sf	UniProtKB/TrEMBL
	Thionin	UniProtKB/TrEMBL
	TIR_dom	UniProtKB/TrEMBL
	Toll-like_receptor	UniProtKB/TrEMBL
	Toll_tir_struct_dom_sf	UniProtKB/TrEMBL
KEGG Report	cfa:488605	UniProtKB/TrEMBL
NCBI Gene	TLR5	ENTREZGENE
PANTHER	PTHR24365	UniProtKB/TrEMBL
	PTHR24365:SF525	UniProtKB/TrEMBL
Pfam	LRR_8	UniProtKB/TrEMBL
	LRRCT	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
PIRSF	Toll-like_receptor	UniProtKB/TrEMBL
PROSITE	LRR	UniProtKB/TrEMBL
	PROKAR_LIPOPROTEIN	UniProtKB/TrEMBL
	THIONIN	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
SMART	LRR_TYP	UniProtKB/TrEMBL
	LRRCT	UniProtKB/TrEMBL
	TIR	UniProtKB/TrEMBL
Superfamily-SCOP	L domain-like	UniProtKB/TrEMBL
	SSF52200	UniProtKB/TrEMBL
UniProt	A0A1P8NLQ2_CANLF	UniProtKB/TrEMBL
	A0A1P8NLS0_CANLF	UniProtKB/TrEMBL
	A0A1P8NLV0_CANLF	UniProtKB/TrEMBL
	A0A8I3NY74	ENTREZGENE, UniProtKB/TrEMBL
	A0A8P0NDI4_CANLF	UniProtKB/TrEMBL
	B2CW36	ENTREZGENE, UniProtKB/TrEMBL
	C3S7P1	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD

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