Tlr5 (toll like receptor 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Tlr5 (toll like receptor 5) Ictidomys tridecemlineatus
Analyze
Symbol: Tlr5
Name: toll like receptor 5
RGD ID: 12641487
Description: ENCODES a protein that exhibits interleukin-1 receptor binding (inferred); pattern recognition receptor activity (inferred); signaling receptor activity (inferred); INVOLVED IN cellular response to lipopolysaccharide (ortholog); male gonad development (ortholog); positive regulation of interleukin-8 production (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH adult respiratory distress syndrome (ortholog); ankylosing spondylitis (ortholog); Bacterial Keratitis (ortholog); FOUND IN plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: toll-like receptor 5
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: SpeTri2.0 - Squirrel SpeTri2.0 Assembly
Position:
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934454,334,832 - 54,363,906 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936526383,418 - 401,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936526383,490 - 387,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
membrane  (IEA)
plasma membrane  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tlr5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934454,334,832 - 54,363,906 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936526383,418 - 401,552 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936526383,490 - 387,007 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381223,109,404 - 223,143,248 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1223,109,404 - 223,143,292 (-)EnsemblGRCh38hg38GRCh38
GRCh371223,282,746 - 223,316,590 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361221,350,207 - 221,383,247 (-)NCBINCBI36Build 36hg18NCBI36
Celera1196,502,104 - 196,535,977 (-)NCBICelera
Cytogenetic Map1q41NCBI
HuRef1193,957,238 - 193,991,230 (-)NCBIHuRef
CHM1_11224,555,804 - 224,589,771 (-)NCBICHM1_1
T2T-CHM13v2.01222,347,318 - 222,381,267 (-)NCBIT2T-CHM13v2.0
Tlr5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391182,782,317 - 182,804,010 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1182,782,353 - 182,804,010 (+)EnsemblGRCm39 Ensembl
GRCm381182,954,752 - 182,976,044 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1182,954,788 - 182,976,044 (+)EnsemblGRCm38mm10GRCm38
MGSCv371184,884,919 - 184,906,175 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361184,884,919 - 184,906,170 (+)NCBIMGSCv36mm8
Celera1189,998,902 - 190,020,262 (+)NCBICelera
Cytogenetic Map1H5NCBI
cM Map186.12NCBI
Tlr5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81397,166,430 - 97,190,642 (+)NCBIGRCr8
mRatBN7.21394,634,778 - 94,658,992 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1394,634,801 - 94,657,738 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1397,156,784 - 97,161,038 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01398,556,697 - 98,560,951 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01395,738,872 - 95,743,126 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.013101,364,784 - 101,385,764 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl13101,381,510 - 101,385,764 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.013106,294,254 - 106,315,238 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41399,025,501 - 99,029,755 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11399,217,286 - 99,217,523 (+)NCBI
Celera1394,180,743 - 94,184,997 (+)NCBICelera
Cytogenetic Map13q26NCBI
Tlr5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555201,556,523 - 1,559,093 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555201,544,840 - 1,562,081 (+)NCBIChiLan1.0ChiLan1.0
TLR5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2126,171,713 - 26,204,781 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1126,127,751 - 26,160,814 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01198,787,046 - 198,819,537 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11203,797,720 - 203,831,605 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1203,798,767 - 203,801,343 (-)Ensemblpanpan1.1panPan2
TLR5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13823,700,323 - 23,705,628 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3823,702,033 - 23,705,314 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3823,729,352 - 23,731,928 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03823,873,004 - 23,878,847 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3823,874,719 - 23,878,000 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13823,620,126 - 23,622,702 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03824,170,412 - 24,172,988 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03824,572,699 - 24,575,275 (+)NCBIUU_Cfam_GSD_1.0
TLR5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1019,387,666 - 19,410,024 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11019,387,666 - 19,410,024 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21021,886,309 - 21,888,880 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1256,418,895 - 6,440,433 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl256,437,638 - 6,440,211 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660556,652,060 - 6,685,032 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tlr5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248355,500,461 - 5,503,034 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248355,495,723 - 5,503,462 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSSTOT00000026274   ⟹   ENSSTOP00000016233
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936526383,418 - 401,552 (-)Ensembl
Ensembl Acc Id: ENSSTOT00000040103   ⟹   ENSSTOP00000029755
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
SpeTri2.0 EnsemblNW_004936526383,418 - 401,552 (-)Ensembl
RefSeq Acc Id: XM_021727158   ⟹   XP_021582833
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934454,356,858 - 54,363,906 (+)NCBI
SpeTri2.0NW_004936526383,490 - 387,007 (-)NCBI
Sequence:
RefSeq Acc Id: XM_040277656   ⟹   XP_040133590
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934454,334,832 - 54,363,906 (+)NCBI
RefSeq Acc Id: XM_040277657   ⟹   XP_040133591
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934454,334,832 - 54,363,906 (+)NCBI
RefSeq Acc Id: XM_040277658   ⟹   XP_040133592
Type: CODING
Position:
Squirrel AssemblyChrPosition (strand)Source
HiC_Itri_2NW_02440934454,356,859 - 54,363,906 (+)NCBI
Protein Sequences
Protein RefSeqs XP_021582833 (Get FASTA)   NCBI Sequence Viewer  
  XP_040133590 (Get FASTA)   NCBI Sequence Viewer  
  XP_040133591 (Get FASTA)   NCBI Sequence Viewer  
  XP_040133592 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSSTOP00000016233.2
  ENSSTOP00000029755.1
GenBank Protein KAG3258034 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021582833   ⟸   XM_021727158
- Peptide Label: isoform X2
- UniProtKB: A0A287D879 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_040133590   ⟸   XM_040277656
- Peptide Label: isoform X1
- UniProtKB: I3MVT8 (UniProtKB/TrEMBL),   A0A287D879 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_040133591   ⟸   XM_040277657
- Peptide Label: isoform X3
RefSeq Acc Id: XP_040133592   ⟸   XM_040277658
- Peptide Label: isoform X4
Ensembl Acc Id: ENSSTOP00000029755   ⟸   ENSSTOT00000040103
Ensembl Acc Id: ENSSTOP00000016233   ⟸   ENSSTOT00000026274
Protein Domains
TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSTOG00000022418 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSSTOT00000026274.2 UniProtKB/TrEMBL
  ENSSTOT00000040103.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
NCBI Gene Tlr5 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  PTHR24365:SF525 UniProtKB/TrEMBL
Pfam LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
PIRSF Toll-like_receptor UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
SMART LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/TrEMBL
  SSF52200 UniProtKB/TrEMBL
UniProt A0A287D879 ENTREZGENE, UniProtKB/TrEMBL
  I3MVT8 ENTREZGENE, UniProtKB/TrEMBL