Iyd (iodotyrosine deiodinase) - Rat Genome Database

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Gene: Iyd (iodotyrosine deiodinase) Rattus norvegicus
Analyze
Symbol: Iyd
Name: iodotyrosine deiodinase
RGD ID: 1309288
Description: Predicted to enable FMN binding activity and iodotyrosine deiodinase activity. Predicted to be involved in thyroid hormone metabolic process and tyrosine metabolic process. Predicted to be located in cytoplasmic vesicle membrane and nucleoplasm. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in thyroid dyshormonogenesis 4. Orthologous to human IYD (iodotyrosine deiodinase); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: iodotyrosine dehalogenase 1; iodotyrosine deiodinase 1; IYD-1; LOC308129; MGC109018; RGD1309288; similar to RIKEN cDNA 0610009A07
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,410,099 - 42,425,414 (+)NCBIGRCr8
mRatBN7.2140,003,999 - 40,019,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl140,004,041 - 40,019,319 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx140,523,642 - 40,538,881 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,510,840 - 46,526,081 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0140,606,684 - 40,621,964 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0140,086,513 - 40,100,966 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,086,470 - 40,101,840 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0141,435,347 - 41,449,800 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,244,640 - 34,259,649 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1134,247,584 - 34,262,592 (+)NCBI
Celera135,702,067 - 35,717,263 (+)NCBICelera
Cytogenetic Map1p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dinitrobenzene  (ISO)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1-monolauroylglycerol  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP)
2,2',4,5'-Tetrabromodiphenyl ether  (ISO)
2,2'-Methylenebis(4-methyl-6-tert-butylphenol)  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,5-trichlorophenol  (ISO)
2,4-di-tert-butylphenol  (ISO)
2,6-di-tert-butylphenol  (ISO)
3,3',4',5-tetrachlorosalicylanilide  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-nitrotyrosine  (ISO)
4,5-dichloro-2-n-octyl-3(2H)-isothiazolone  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nonylphenol  (ISO)
4-octylphenol  (ISO)
4-tert-Octylphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
benzalkonium chloride  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bithionol  (ISO)
Brilliant Blue  (ISO)
bromophenol blue  (ISO)
calcitriol  (ISO)
captan  (ISO)
cetyltrimethylammonium ion  (ISO)
chlordecone  (ISO)
chlorhexidine  (ISO)
clomiphene  (ISO)
cyclosporin A  (ISO)
DDT  (ISO)
dibutyl phthalate  (ISO)
Dichlorophen  (ISO)
dicofol  (ISO)
Didecyldimethylammonium  (ISO)
dinocap  (ISO)
dioxygen  (ISO)
Dodecyl gallate  (ISO)
dodecylbenzenesulfonic acid  (ISO)
dodecyltrimethylammonium ion  (ISO)
endosulfan  (EXP)
eosin YS dye  (ISO)
erythrosin B  (ISO)
Fast green FCF  (ISO)
fenthion  (ISO)
flusalan  (ISO)
flutamide  (EXP)
folpet  (ISO)
glafenine  (EXP)
hexadecanoic acid  (ISO)
linoleic acid  (ISO)
masoprocol  (ISO)
methidathion  (ISO)
methimazole  (EXP)
methyl linoleate  (ISO)
Methylbenzethonium chloride  (ISO)
methylene blue  (ISO)
methyltrioctylammonium chloride  (ISO)
monoiodotyrosine  (ISO)
morin  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
nitrofurazone  (ISO)
O-methyleugenol  (ISO)
octyl gallate  (ISO)
oleic acid  (ISO)
p-tert-Amylphenol  (ISO)
paracetamol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluoroundecanoic acid  (ISO)
phthalaldehyde  (ISO)
rac-1-monolauroylglycerol  (ISO)
resveratrol  (ISO)
riboflavin  (ISO)
rose bengal  (ISO)
rotenone  (EXP)
Sirius red 4B  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
sodium iodide  (EXP)
sodium myristyl sulfate  (ISO)
tamoxifen  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
tetradecanoic acid  (ISO)
thioacetamide  (EXP)
tribromosalicylanilide  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasmic vesicle membrane  (ISO,ISS)
nucleoplasm  (IEA,ISO)
plasma membrane  (IBA,ISO,ISS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15289438   PMID:15489334   PMID:16316988   PMID:25395621   PMID:25850545  


Genomics

Comparative Map Data
Iyd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8142,410,099 - 42,425,414 (+)NCBIGRCr8
mRatBN7.2140,003,999 - 40,019,323 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl140,004,041 - 40,019,319 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx140,523,642 - 40,538,881 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,510,840 - 46,526,081 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0140,606,684 - 40,621,964 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0140,086,513 - 40,100,966 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,086,470 - 40,101,840 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0141,435,347 - 41,449,800 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4134,244,640 - 34,259,649 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1134,247,584 - 34,262,592 (+)NCBI
Celera135,702,067 - 35,717,263 (+)NCBICelera
Cytogenetic Map1p11NCBI
IYD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386150,369,012 - 150,405,969 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6150,368,892 - 150,405,969 (+)EnsemblGRCh38hg38GRCh38
GRCh376150,690,148 - 150,727,105 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366150,731,721 - 150,767,457 (+)NCBINCBI36Build 36hg18NCBI36
Build 346150,782,141 - 150,817,878NCBI
Celera6151,424,947 - 151,460,709 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6148,255,114 - 148,290,675 (+)NCBIHuRef
CHM1_16150,954,100 - 150,989,630 (+)NCBICHM1_1
T2T-CHM13v2.06151,569,713 - 151,606,528 (+)NCBIT2T-CHM13v2.0
Iyd
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39103,490,274 - 3,504,880 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl103,490,240 - 3,504,877 (+)EnsemblGRCm39 Ensembl
GRCm38103,540,274 - 3,554,880 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl103,540,240 - 3,554,877 (+)EnsemblGRCm38mm10GRCm38
MGSCv37106,791,664 - 6,806,262 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36106,791,664 - 6,806,262 (-)NCBIMGSCv36mm8
Celera103,484,500 - 3,499,071 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.06NCBI
Iyd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543911,033,302 - 11,060,150 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543910,998,797 - 11,060,078 (-)NCBIChiLan1.0ChiLan1.0
IYD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25170,384,566 - 170,422,587 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16168,278,049 - 168,316,060 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06148,178,638 - 148,216,122 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16152,886,367 - 152,922,152 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6152,886,373 - 152,922,152 (+)Ensemblpanpan1.1panPan2
IYD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1140,890,402 - 40,908,437 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl140,890,435 - 40,908,439 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha141,728,455 - 41,748,252 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0141,072,192 - 41,090,715 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl141,072,213 - 41,090,215 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1140,947,672 - 40,967,446 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0140,791,294 - 40,809,809 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0141,295,459 - 41,313,980 (+)NCBIUU_Cfam_GSD_1.0
Iyd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946136,202,719 - 136,221,695 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364893,454,757 - 3,472,474 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364893,454,757 - 3,472,423 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IYD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl115,756,550 - 15,779,164 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1115,756,536 - 15,779,380 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,891,407 - 17,908,117 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IYD
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11377,794,539 - 77,828,841 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1377,795,079 - 77,822,379 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604050,104,222 - 50,134,595 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Iyd
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247857,800,408 - 7,824,647 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247857,799,975 - 7,824,611 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Iyd
25 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:44
Count of miRNA genes:40
Interacting mature miRNAs:42
Transcripts:ENSRNOT00000021895
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
738020Pia8Pristane induced arthritis QTL 84.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1165833076Rat
1578650Bmd6Bone mineral density QTL 612.2femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)150910843284926Rat
1578651Bmd7Bone mineral density QTL 714.2femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)150910843284926Rat
1578669Bss9Bone structure and strength QTL 96.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)150910843284926Rat
1554320Bmd1Bone mineral density QTL 112.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)150910886060548Rat
1600360Mcs16Mammary carcinoma susceptibility QTL 162.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1224439043433040Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1439328949393289Rat
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)15925874115540829Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)1985600154856001Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11099206555992065Rat
1300167Hrtrt2Heart rate QTL 24.35heart pumping trait (VT:2000009)heart rate (CMO:0000002)11148131275088344Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)11148131282174945Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)11148131282174945Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)11148131282174945Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)11148131282174945Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)11148131282174945Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)11183518156835181Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)11543162149361612Rat
5684999Bss102Bone structure and strength QTL 1025.50.00000072tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)11543162149361612Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11620621049268520Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)11933357156983283Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)12076315844095856Rat
724520Bp145Blood pressure QTL 1452.10.0024arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)12078482865784828Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)12234064749361612Rat
1357400Bw62Body weight QTL624.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)12234064767340647Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)122340647102268831Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)12887978078430678Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)130882023123479925Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13273727390665040Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)13344984878449848Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)13344984878449848Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)13483685879836858Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)13483685879836858Rat
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)13523959878430678Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)13523959878430678Rat

Markers in Region
RH132943  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2140,018,919 - 40,019,124 (+)MAPPERmRatBN7.2
Rnor_6.0140,100,563 - 40,100,767NCBIRnor6.0
Rnor_5.0141,449,397 - 41,449,601UniSTSRnor5.0
RGSC_v3.4134,259,246 - 34,259,450UniSTSRGSC3.4
Celera135,716,860 - 35,717,064UniSTS
Cytogenetic Map1p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 21 21 21 21
Low 17 16 16 3 10 3 1
Below cutoff 2 26 15 4 8 4 4 4 51 15 9 4

Sequence


RefSeq Acc Id: ENSRNOT00000021895   ⟹   ENSRNOP00000021893
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl140,004,041 - 40,019,319 (+)Ensembl
Rnor_6.0 Ensembl140,086,470 - 40,101,840 (+)Ensembl
RefSeq Acc Id: NM_001025000   ⟹   NP_001020171
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,410,138 - 42,425,414 (+)NCBI
mRatBN7.2140,004,041 - 40,019,323 (+)NCBI
Rnor_6.0140,086,513 - 40,100,966 (+)NCBI
Rnor_5.0141,435,347 - 41,449,800 (+)NCBI
RGSC_v3.4134,244,640 - 34,259,649 (+)RGD
Celera135,702,067 - 35,717,263 (+)RGD
Sequence:
RefSeq Acc Id: XM_039110644   ⟹   XP_038966572
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8142,410,099 - 42,425,414 (+)NCBI
mRatBN7.2140,003,999 - 40,018,788 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001020171 (Get FASTA)   NCBI Sequence Viewer  
  XP_038966572 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91241 (Get FASTA)   NCBI Sequence Viewer  
  EDL92877 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000021893
  ENSRNOP00000021893.4
  ENSRNOP00055029761
  ENSRNOP00060000183
  ENSRNOP00065002401
GenBank Protein Q5BK17 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020171   ⟸   NM_001025000
- UniProtKB: Q5BK17 (UniProtKB/Swiss-Prot),   A6KIK2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000021893   ⟸   ENSRNOT00000021895
RefSeq Acc Id: XP_038966572   ⟸   XM_039110644
- Peptide Label: isoform X1
Protein Domains
Nitroreductase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BK17-F1-model_v2 AlphaFold Q5BK17 1-285 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689582
Promoter ID:EPDNEW_R107
Type:multiple initiation site
Name:Iyd_1
Description:iodotyrosine deiodinase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0140,086,503 - 40,086,563EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1309288 AgrOrtholog
BioCyc Gene G2FUF-61731 BioCyc
Ensembl Genes ENSRNOG00000016286 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055021444 UniProtKB/Swiss-Prot
  ENSRNOG00060000700 UniProtKB/Swiss-Prot
  ENSRNOG00065002607 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000021895 ENTREZGENE
  ENSRNOT00000021895.8 UniProtKB/Swiss-Prot
  ENSRNOT00055036634 UniProtKB/Swiss-Prot
  ENSRNOT00060000795 UniProtKB/Swiss-Prot
  ENSRNOT00065003469 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.109.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7326298 IMAGE-MGC_LOAD
InterPro Nitroreductase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nitroreductase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:308129 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:109018 IMAGE-MGC_LOAD
NCBI Gene 308129 ENTREZGENE
PANTHER IODOTYROSINE DEIODINASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NADPH NITROREDUCTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Nitroreductase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Iyd PhenoGen
RatGTEx ENSRNOG00000016286 RatGTEx
  ENSRNOG00055021444 RatGTEx
  ENSRNOG00060000700 RatGTEx
  ENSRNOG00065002607 RatGTEx
Superfamily-SCOP FMN-dependent nitroreductase-like UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KIK2 ENTREZGENE, UniProtKB/TrEMBL
  IYD1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Iyd  iodotyrosine deiodinase  RGD1309288  similar to RIKEN cDNA 0610009A07  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1309288  similar to RIKEN cDNA 0610009A07  RGD1309288_predicted  similar to RIKEN cDNA 0610009A07 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1309288_predicted  similar to RIKEN cDNA 0610009A07 (predicted)  LOC308129_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC308129_predicted  similar to RIKEN cDNA 0610009A07 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL