Gene: Socs2 (suppressor of cytokine signaling 2) Rattus norvegicus
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Symbol: Socs2
Name: suppressor of cytokine signaling 2
Description: ENCODES a protein that exhibits growth hormone receptor binding (ortholog); insulin-like growth factor receptor binding (ortholog); INVOLVED IN aging; response to peptide hormone; cellular response to hormone stimulus (ortholog); PARTICIPATES IN interleukin-2 signaling pathway; Jak-Stat signaling pathway; insulin signaling pathway; ASSOCIATED WITH Sepsis; Spinal Cord Injuries; allergic contact dermatitis (ortholog); FOUND IN cytoplasm (inferred); INTERACTS WITH 1,3-dinitrobenzene; 3H-1,2-dithiole-3-thione; 4,4'-diaminodiphenylmethane
AGR Description: Predicted to have 1-phosphatidylinositol-3-kinase regulator activity, growth hormone receptor binding activity, and insulin-like growth factor receptor binding activity; involved in aging and response to peptide hormone; predicted to localize to the phosphatidylinositol 3-kinase complex; orthologous to human SOCS2 (suppressor of cytokine signaling 2).
Merged Description: Predicted to have 1-phosphatidylinositol-3-kinase regulator activity, growth hormone receptor binding activity, and insulin-like growth factor receptor binding activity; involved in aging and response to peptide hormone; predicted to localize to the phosphatidylinositol 3-kinase complex; orthologous to human SOCS2 (suppressor of cytokine signaling 2); PARTICIPATES IN interleukin-2 signaling pathway; Jak-Stat signaling pathway; insulin signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 3H-1,2-dithiole-3-thione; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cish2; cytokine inducible SH2-containing protein 2; cytokine-inducible SH2 protein 2; Socs-2
Orthologs:
Homo sapiens (human) : SOCS2 (suppressor of cytokine signaling 2)  HGNC  Alliance
Mus musculus (house mouse) : Socs2 (suppressor of cytokine signaling 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Socs2 (suppressor of cytokine signaling 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SOCS2 (suppressor of cytokine signaling 2)
Canis lupus familiaris (dog) : SOCS2 (suppressor of cytokine signaling 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Socs2 (suppressor of cytokine signaling 2)
Sus scrofa (pig) : SOCS2 (suppressor of cytokine signaling 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0736,495,496 - 36,500,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0736,558,014 - 36,560,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4732,605,714 - 32,608,323 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1732,625,999 - 32,628,594 (-)NCBI
Celera727,114,252 - 27,116,861 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Socs2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69273
Created: 2001-11-14
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.