Socs2 (suppressor of cytokine signaling 2) - Rat Genome Database

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Gene: Socs2 (suppressor of cytokine signaling 2) Rattus norvegicus
Analyze
Symbol: Socs2
Name: suppressor of cytokine signaling 2
RGD ID: 69273
Description: Predicted to enable phosphorylation-dependent protein binding activity; signaling receptor binding activity; and ubiquitin-like ligase-substrate adaptor activity. Involved in response to peptide hormone. Predicted to be part of Cul5-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2); PARTICIPATES IN interleukin-2 signaling pathway; Jak-Stat signaling pathway; insulin signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cish2; cytokine inducible SH2-containing protein 2; cytokine-inducible SH2 protein 2; Socs-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8731,890,564 - 31,932,092 (-)NCBIGRCr8
GRCr8 Ensembl731,874,463 - 31,930,423 (-)EnsemblGRCr8 Ensembl
mRatBN7.2730,006,360 - 30,045,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl730,008,578 - 30,043,548 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx732,027,095 - 32,029,699 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0734,201,426 - 34,204,033 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0733,970,650 - 33,973,258 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0736,495,496 - 36,500,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl736,495,480 - 36,499,784 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0736,558,014 - 36,560,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4732,605,714 - 32,608,323 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera727,114,252 - 27,116,861 (-)NCBICelera
RGSC_v3.1732,625,999 - 32,628,594 (-)NCBI
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,4'-trichlorobiphenyl  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
antigen  (ISO)
antimycin A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clorgyline  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
D-glucose  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gefitinib  (ISO)
genistein  (ISO)
glucose  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
GSK-J4  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lipoxin A4  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
niclosamide  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
PCB138  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
starch  (EXP)
sulfadimethoxine  (EXP)
sulfasalazine  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Methylated DNA collected by tampons--a new tool to detect endometrial cancer. Fiegl H, etal., Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):882-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. SOCS2 induces neurite outgrowth by regulation of epidermal growth factor receptor activation. Goldshmit Y, etal., J Biol Chem 2004 Apr 16;279(16):16349-55. Epub 2004 Feb 4.
4. Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy. Haddad F and Adams GR, J Appl Physiol. 2006 Apr;100(4):1188-203. Epub 2005 Dec 22.
5. Favorable prognostic value of SOCS2 and IGF-I in breast cancer. Haffner MC, etal., BMC Cancer. 2007 Jul 25;7:136.
6. Evolution of the androgen receptor pathway during progression of prostate cancer. Hendriksen PJ, etal., Cancer Res. 2006 May 15;66(10):5012-20.
7. Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Hong-Brown LQ, etal., Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E63-72. Epub 2003 Mar 18.
8. Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat. Johnson TS, etal., J Endocrinol 2001 May;169(2):409-15.
9. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. Raccurt M, etal., Br J Cancer. 2003 Aug 4;89(3):524-32.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. GeneChip analysis after acute spinal cord injury in rat. Song G, etal., J Neurochem. 2001 Nov;79(4):804-15.
19. Differential hypermethylation of SOCS genes in ovarian and breast carcinomas. Sutherland KD, etal., Oncogene. 2004 Oct 7;23(46):7726-33.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9727029   PMID:10579313   PMID:11401434   PMID:11445538   PMID:12368809   PMID:12552091   PMID:14614901   PMID:15167538   PMID:15300589   PMID:15690087   PMID:15831713   PMID:16469767  
PMID:16956890   PMID:17008382   PMID:17986523   PMID:19008912   PMID:19469688   PMID:28867579  


Genomics

Comparative Map Data
Socs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8731,890,564 - 31,932,092 (-)NCBIGRCr8
GRCr8 Ensembl731,874,463 - 31,930,423 (-)EnsemblGRCr8 Ensembl
mRatBN7.2730,006,360 - 30,045,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl730,008,578 - 30,043,548 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx732,027,095 - 32,029,699 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0734,201,426 - 34,204,033 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0733,970,650 - 33,973,258 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0736,495,496 - 36,500,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl736,495,480 - 36,499,784 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0736,558,014 - 36,560,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4732,605,714 - 32,608,323 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera727,114,252 - 27,116,861 (-)NCBICelera
RGSC_v3.1732,625,999 - 32,628,594 (-)NCBI
Cytogenetic Map7q13NCBI
SOCS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381293,569,969 - 93,626,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1293,569,814 - 93,583,487 (+)EnsemblGRCh38hg38GRCh38
GRCh371293,963,745 - 93,970,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361292,487,729 - 92,494,109 (+)NCBINCBI36Build 36hg18NCBI36
Build 341292,466,065 - 92,472,446NCBI
Celera1293,634,235 - 93,640,615 (+)NCBICelera
Cytogenetic Map12q22NCBI
HuRef1291,011,433 - 91,037,277 (+)NCBIHuRef
CHM1_11293,928,550 - 93,935,473 (+)NCBICHM1_1
T2T-CHM13v2.01293,551,422 - 93,607,676 (+)NCBIT2T-CHM13v2.0
Socs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391095,219,765 - 95,253,176 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1095,221,224 - 95,253,042 (-)EnsemblGRCm39 Ensembl
GRCm381095,383,903 - 95,417,321 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1095,385,362 - 95,417,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv371094,874,124 - 94,879,491 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361094,841,730 - 94,846,509 (-)NCBIMGSCv36mm8
Celera1097,386,894 - 97,392,261 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1049.35NCBI
Socs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540530,366,866 - 30,375,468 (+)EnsemblChiLan1.0
ChiLan1.0 EnsemblNW_00495540530,451,887 - 30,623,230 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540530,349,956 - 30,623,849 (+)NCBIChiLan1.0ChiLan1.0
SOCS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v210101,615,299 - 101,632,031 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan112101,611,649 - 101,628,420 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01291,115,319 - 91,134,191 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11294,514,455 - 94,520,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1294,514,455 - 94,520,748 (+)Ensemblpanpan1.1panPan2
SOCS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11533,761,434 - 33,788,973 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1533,785,545 - 33,877,869 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1534,233,462 - 34,239,473 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01534,451,284 - 34,457,258 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1534,451,551 - 34,494,605 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11533,731,935 - 33,737,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01533,821,213 - 33,827,198 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01534,083,449 - 34,089,425 (+)NCBIUU_Cfam_GSD_1.0
Socs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494526,219,956 - 26,221,450 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650710,012,101 - 10,014,456 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493650710,013,982 - 10,015,480 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl589,581,090 - 89,584,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1589,581,081 - 89,587,424 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2593,712,446 - 93,718,768 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SOCS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11188,964,805 - 88,971,147 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1188,966,940 - 88,971,515 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037156,190,952 - 156,197,857 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475013,333,393 - 13,339,018 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Socs2
417 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:21
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000011948
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)72154197751639954Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72380760668807606Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72663805771638057Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72417947886817926Rat
1358361Sradr5Stress Responsive Adrenal Weight QTL 55.55adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)731770293110435881Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)72154197751639954Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)72154197735707405Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72862457565788017Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)72154197786817926Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72092049437412865Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71746044762460447Rat
70207Niddm31Non-insulin dependent diabetes mellitus QTL 313.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)72005723265057232Rat
61439Cia8Collagen induced arthritis QTL 85.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)72718291472182914Rat

Markers in Region
D7Wox52  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8731,927,841 - 31,927,986 (+)Marker Load Pipeline
mRatBN7.2730,040,966 - 30,041,111 (+)MAPPERmRatBN7.2
Rnor_6.0736,496,639 - 36,496,783NCBIRnor6.0
Rnor_5.0736,558,042 - 36,558,186UniSTSRnor5.0
RGSC_v3.4732,605,742 - 32,605,886UniSTSRGSC3.4
Celera727,114,280 - 27,114,424UniSTS
Cytogenetic Map7q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000011948   ⟹   ENSRNOP00000011948
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl731,926,200 - 31,930,423 (-)Ensembl
mRatBN7.2 Ensembl730,039,830 - 30,043,548 (-)Ensembl
Rnor_6.0 Ensembl736,495,480 - 36,499,784 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103867   ⟹   ENSRNOP00000089730
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl731,895,378 - 31,930,423 (-)Ensembl
mRatBN7.2 Ensembl730,008,578 - 30,043,548 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000123921   ⟹   ENSRNOP00000105455
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl731,874,463 - 31,930,423 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000139499   ⟹   ENSRNOP00000104497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl731,898,009 - 31,930,423 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000159016   ⟹   ENSRNOP00000111837
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl731,915,579 - 31,930,423 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000167189   ⟹   ENSRNOP00000100589
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl731,901,197 - 31,930,423 (-)Ensembl
RefSeq Acc Id: NM_058208   ⟹   NP_478115
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8731,927,814 - 31,930,423 (-)NCBI
mRatBN7.2730,040,939 - 30,043,548 (-)NCBI
Rnor_6.0736,496,611 - 36,499,220 (-)NCBI
Rnor_5.0736,558,014 - 36,560,623 (-)NCBI
RGSC_v3.4732,605,714 - 32,608,323 (-)RGD
Celera727,114,252 - 27,116,861 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595137   ⟹   XP_017450626
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8731,926,708 - 31,932,075 (-)NCBI
mRatBN7.2730,039,832 - 30,045,156 (-)NCBI
Rnor_6.0736,495,496 - 36,500,878 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079991   ⟹   XP_038935919
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8731,890,564 - 31,931,805 (-)NCBI
mRatBN7.2730,008,522 - 30,044,621 (-)NCBI
RefSeq Acc Id: XM_039079992   ⟹   XP_038935920
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8731,890,564 - 31,931,098 (-)NCBI
mRatBN7.2730,008,522 - 30,044,136 (-)NCBI
RefSeq Acc Id: XM_039079993   ⟹   XP_038935921
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8731,900,317 - 31,932,075 (-)NCBI
mRatBN7.2730,015,301 - 30,045,158 (-)NCBI
RefSeq Acc Id: XM_063264345   ⟹   XP_063120415
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8731,926,708 - 31,931,805 (-)NCBI
RefSeq Acc Id: XM_063264346   ⟹   XP_063120416
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8731,926,708 - 31,931,806 (-)NCBI
RefSeq Acc Id: XM_063264347   ⟹   XP_063120417
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8731,930,281 - 31,932,092 (-)NCBI
RefSeq Acc Id: NP_478115   ⟸   NM_058208
- UniProtKB: O88582 (UniProtKB/Swiss-Prot),   A6IG33 (UniProtKB/TrEMBL),   A6IG31 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017450626   ⟸   XM_017595137
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000011948   ⟸   ENSRNOT00000011948
RefSeq Acc Id: XP_038935919   ⟸   XM_039079991
- Peptide Label: isoform X1
- UniProtKB: A6IG31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935920   ⟸   XM_039079992
- Peptide Label: isoform X1
- UniProtKB: A6IG31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935921   ⟸   XM_039079993
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AD64 (UniProtKB/TrEMBL),   A6IG31 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000089730   ⟸   ENSRNOT00000103867
RefSeq Acc Id: XP_063120416   ⟸   XM_063264346
- Peptide Label: isoform X2
- UniProtKB: O88582 (UniProtKB/Swiss-Prot),   A6IG33 (UniProtKB/TrEMBL),   A6IG31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120415   ⟸   XM_063264345
- Peptide Label: isoform X2
- UniProtKB: O88582 (UniProtKB/Swiss-Prot),   A6IG33 (UniProtKB/TrEMBL),   A6IG31 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120417   ⟸   XM_063264347
- Peptide Label: isoform X4
Ensembl Acc Id: ENSRNOP00000105455   ⟸   ENSRNOT00000123921
Ensembl Acc Id: ENSRNOP00000111837   ⟸   ENSRNOT00000159016
Ensembl Acc Id: ENSRNOP00000104497   ⟸   ENSRNOT00000139499
Ensembl Acc Id: ENSRNOP00000100589   ⟸   ENSRNOT00000167189
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88582-F1-model_v2 AlphaFold O88582 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69273 AgrOrtholog
BioCyc Gene G2FUF-34340 BioCyc
Ensembl Genes ENSRNOG00000008965 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000103867 ENTREZGENE
  ENSRNOT00000167189 ENTREZGENE
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot
  SOCS box UniProtKB/Swiss-Prot
InterPro SH2 UniProtKB/Swiss-Prot
  SH2_dom_sf UniProtKB/Swiss-Prot
  SOCS2_SH2 UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:84607 UniProtKB/Swiss-Prot
NCBI Gene 84607 ENTREZGENE
PANTHER PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT UniProtKB/Swiss-Prot
  PTHR10155:SF7 UniProtKB/Swiss-Prot
Pfam SH2 UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
PhenoGen Socs2 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot
PROSITE SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000008965 RatGTEx
SMART SH2 UniProtKB/Swiss-Prot
  SOCS UniProtKB/Swiss-Prot
  SOCS_box UniProtKB/Swiss-Prot
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot
  SSF55550 UniProtKB/Swiss-Prot
TIGR TC225712
UniProt A0A0H2UHH1_RAT UniProtKB/TrEMBL
  A0A8I6AD64 ENTREZGENE, UniProtKB/TrEMBL
  A6IG31 ENTREZGENE, UniProtKB/TrEMBL
  A6IG32_RAT UniProtKB/TrEMBL
  A6IG33 ENTREZGENE, UniProtKB/TrEMBL
  A6IG36_RAT UniProtKB/TrEMBL
  O88582 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Socs2  suppressor of cytokine signaling 2  Cish2  cytokine inducible SH2-containing protein 2  Symbol and Name updated 1299863 APPROVED
2002-06-10 Cish2  cytokine inducible SH2-containing protein 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process negative regulator of growth hormone (GH) signaling that regulates body growth postnatally and neuronal differentiation during development 1302348
gene_product member of a family of negative regulators of cytokine signalling 634752