Socs2 (suppressor of cytokine signaling 2) - Rat Genome Database

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Gene: Socs2 (suppressor of cytokine signaling 2) Rattus norvegicus
Analyze
Symbol: Socs2
Name: suppressor of cytokine signaling 2
RGD ID: 69273
Description: Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity; growth hormone receptor binding activity; and insulin-like growth factor receptor binding activity. Involved in aging and response to peptide hormone. Predicted to be part of phosphatidylinositol 3-kinase complex. Human ortholog(s) of this gene implicated in endometrial cancer and ovarian carcinoma. Orthologous to human SOCS2 (suppressor of cytokine signaling 2); PARTICIPATES IN interleukin-2 signaling pathway; Jak-Stat signaling pathway; insulin signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cish2; cytokine inducible SH2-containing protein 2; cytokine-inducible SH2 protein 2; Socs-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2730,006,360 - 30,045,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl730,008,578 - 30,043,548 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx732,027,095 - 32,029,699 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0734,201,426 - 34,204,033 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0733,970,650 - 33,973,258 (-)NCBIRnor_WKY
Rnor_6.0736,495,496 - 36,500,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl736,495,480 - 36,499,784 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0736,558,014 - 36,560,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4732,605,714 - 32,608,323 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1732,625,999 - 32,628,594 (-)NCBI
Celera727,114,252 - 27,116,861 (-)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antigen  (ISO)
antimycin A  (ISO)
azoxystrobin  (ISO)
benzo[a]pyrene  (ISO)
benzoates  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clorgyline  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyanocob(III)alamin  (ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
entinostat  (ISO)
enzalutamide  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
fenpyroximate  (ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
gamma-hexachlorocyclohexane  (EXP)
genistein  (ISO)
glycine betaine  (ISO)
glyphosate  (ISO)
hexachlorobenzene  (EXP)
hexadecanoic acid  (ISO)
isotretinoin  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
lipoxin A4  (ISO)
mercury dibromide  (ISO)
metacetamol  (ISO)
methapyrilene  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
monosodium L-glutamate  (EXP)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (ISO)
oleic acid  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
PCB138  (ISO)
perfluorooctanoic acid  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
picoxystrobin  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
protein kinase inhibitor  (ISO)
resveratrol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sotorasib  (ISO)
starch  (EXP)
sulfasalazine  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
thioacetamide  (EXP)
trametinib  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
trovafloxacin  (EXP,ISO)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (EXP,ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
zinc atom  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Methylated DNA collected by tampons--a new tool to detect endometrial cancer. Fiegl H, etal., Cancer Epidemiol Biomarkers Prev. 2004 May;13(5):882-8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. SOCS2 induces neurite outgrowth by regulation of epidermal growth factor receptor activation. Goldshmit Y, etal., J Biol Chem 2004 Apr 16;279(16):16349-55. Epub 2004 Feb 4.
4. Aging-sensitive cellular and molecular mechanisms associated with skeletal muscle hypertrophy. Haddad F and Adams GR, J Appl Physiol. 2006 Apr;100(4):1188-203. Epub 2005 Dec 22.
5. Favorable prognostic value of SOCS2 and IGF-I in breast cancer. Haffner MC, etal., BMC Cancer. 2007 Jul 25;7:136.
6. Evolution of the androgen receptor pathway during progression of prostate cancer. Hendriksen PJ, etal., Cancer Res. 2006 May 15;66(10):5012-20.
7. Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation. Hong-Brown LQ, etal., Am J Physiol Endocrinol Metab. 2003 Jul;285(1):E63-72. Epub 2003 Mar 18.
8. Differential expression of suppressors of cytokine signalling genes in response to nutrition and growth hormone in the septic rat. Johnson TS, etal., J Endocrinol 2001 May;169(2):409-15.
9. Signaling through the JAK/STAT pathway, recent advances and future challenges. Kisseleva T, etal., Gene 2002 Feb 20;285(1-2):1-24.
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
14. Suppressor of cytokine signalling gene expression is elevated in breast carcinoma. Raccurt M, etal., Br J Cancer. 2003 Aug 4;89(3):524-32.
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Comprehensive gene review and curation RGD comprehensive gene curation
18. GeneChip analysis after acute spinal cord injury in rat. Song G, etal., J Neurochem. 2001 Nov;79(4):804-15.
19. Differential hypermethylation of SOCS genes in ovarian and breast carcinomas. Sutherland KD, etal., Oncogene. 2004 Oct 7;23(46):7726-33.
20. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:9727029   PMID:10579313   PMID:11401434   PMID:11445538   PMID:12368809   PMID:12552091   PMID:14614901   PMID:15167538   PMID:15300589   PMID:15690087   PMID:15831713   PMID:16469767  
PMID:16956890   PMID:17008382   PMID:17986523   PMID:19008912   PMID:19469688   PMID:28867579  


Genomics

Comparative Map Data
Socs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2730,006,360 - 30,045,161 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl730,008,578 - 30,043,548 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx732,027,095 - 32,029,699 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0734,201,426 - 34,204,033 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0733,970,650 - 33,973,258 (-)NCBIRnor_WKY
Rnor_6.0736,495,496 - 36,500,878 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl736,495,480 - 36,499,784 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0736,558,014 - 36,560,623 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4732,605,714 - 32,608,323 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1732,625,999 - 32,628,594 (-)NCBI
Celera727,114,252 - 27,116,861 (-)NCBICelera
Cytogenetic Map7q13NCBI
SOCS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381293,569,969 - 93,626,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1293,569,814 - 93,583,487 (+)EnsemblGRCh38hg38GRCh38
GRCh371293,963,745 - 93,970,521 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361292,487,729 - 92,494,109 (+)NCBINCBI36Build 36hg18NCBI36
Build 341292,466,065 - 92,472,446NCBI
Celera1293,634,235 - 93,640,615 (+)NCBICelera
Cytogenetic Map12q22NCBI
HuRef1291,011,433 - 91,037,277 (+)NCBIHuRef
CHM1_11293,928,550 - 93,935,473 (+)NCBICHM1_1
T2T-CHM13v2.01293,551,422 - 93,558,195 (+)NCBIT2T-CHM13v2.0
Socs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391095,219,765 - 95,253,176 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1095,221,224 - 95,253,042 (-)EnsemblGRCm39 Ensembl
GRCm381095,383,903 - 95,417,321 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1095,385,362 - 95,417,180 (-)EnsemblGRCm38mm10GRCm38
MGSCv371094,874,124 - 94,879,491 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361094,841,730 - 94,846,509 (-)NCBIMGSCv36mm8
Celera1097,386,894 - 97,392,261 (-)NCBICelera
Cytogenetic Map10C2NCBI
cM Map1049.35NCBI
Socs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540530,366,866 - 30,375,468 (+)EnsemblChiLan1.0
ChiLan1.0 EnsemblNW_00495540530,451,887 - 30,623,230 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540530,349,956 - 30,623,849 (+)NCBIChiLan1.0ChiLan1.0
SOCS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11294,514,455 - 94,520,748 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1294,514,455 - 94,520,748 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01291,115,319 - 91,134,191 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
SOCS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11533,761,434 - 33,788,973 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1533,785,545 - 33,877,869 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1534,233,462 - 34,239,473 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01534,451,284 - 34,457,258 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1534,451,551 - 34,494,605 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11533,731,935 - 33,737,949 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01533,821,213 - 33,827,198 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01534,083,449 - 34,089,425 (+)NCBIUU_Cfam_GSD_1.0
Socs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494526,219,956 - 26,221,450 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650710,012,101 - 10,014,456 (+)EnsemblSpeTri2.0
SpeTri2.0NW_00493650710,013,982 - 10,015,480 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SOCS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl589,581,090 - 89,584,581 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1589,581,081 - 89,587,424 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2593,712,446 - 93,718,768 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SOCS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11188,964,805 - 88,971,147 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1188,966,940 - 88,971,515 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037156,190,952 - 156,197,857 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Socs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475013,333,393 - 13,339,018 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Socs2
183 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:22
Count of miRNA genes:21
Interacting mature miRNAs:22
Transcripts:ENSRNOT00000011948
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)72940968353612950Rat
10402855Bp379Blood pressure QTL 3790.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)72940968374409683Rat
1300127Srn1Serum renin concentration QTL 13.87blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)72940968384928080Rat

Markers in Region
D7Wox52  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2730,040,966 - 30,041,111 (+)MAPPERmRatBN7.2
Rnor_6.0736,496,639 - 36,496,783NCBIRnor6.0
Rnor_5.0736,558,042 - 36,558,186UniSTSRnor5.0
RGSC_v3.4732,605,742 - 32,605,886UniSTSRGSC3.4
Celera727,114,280 - 27,114,424UniSTS
Cytogenetic Map7q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 52 37 19 37 1 50 24 32 11
Low 5 4 4 8 10 24 11 9 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000011948   ⟹   ENSRNOP00000011948
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl730,039,830 - 30,043,548 (-)Ensembl
Rnor_6.0 Ensembl736,495,480 - 36,499,784 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103867   ⟹   ENSRNOP00000089730
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl730,008,578 - 30,043,548 (-)Ensembl
RefSeq Acc Id: NM_058208   ⟹   NP_478115
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2730,040,939 - 30,043,548 (-)NCBI
Rnor_6.0736,496,611 - 36,499,220 (-)NCBI
Rnor_5.0736,558,014 - 36,560,623 (-)NCBI
RGSC_v3.4732,605,714 - 32,608,323 (-)RGD
Celera727,114,252 - 27,116,861 (-)RGD
Sequence:
RefSeq Acc Id: XM_017595137   ⟹   XP_017450626
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2730,039,832 - 30,045,156 (-)NCBI
Rnor_6.0736,495,496 - 36,500,878 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079990   ⟹   XP_038935918
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2730,006,360 - 30,045,161 (-)NCBI
RefSeq Acc Id: XM_039079991   ⟹   XP_038935919
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2730,008,522 - 30,044,621 (-)NCBI
RefSeq Acc Id: XM_039079992   ⟹   XP_038935920
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2730,008,522 - 30,044,136 (-)NCBI
RefSeq Acc Id: XM_039079993   ⟹   XP_038935921
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2730,015,301 - 30,045,158 (-)NCBI
RefSeq Acc Id: XR_005486731
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2730,008,519 - 30,045,159 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_478115   ⟸   NM_058208
- UniProtKB: O88582 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017450626   ⟸   XM_017595137
- Peptide Label: isoform X2
- UniProtKB: O88582 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000011948   ⟸   ENSRNOT00000011948
RefSeq Acc Id: XP_038935918   ⟸   XM_039079990
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038935919   ⟸   XM_039079991
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038935920   ⟸   XM_039079992
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038935921   ⟸   XM_039079993
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AD64 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000089730   ⟸   ENSRNOT00000103867
Protein Domains
SH2   SOCS box

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O88582-F1-model_v2 AlphaFold O88582 1-198 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69273 AgrOrtholog
BioCyc Gene G2FUF-34340 BioCyc
Ensembl Genes ENSRNOG00000008965 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000011948.3 UniProtKB/TrEMBL
  ENSRNOP00000089730 ENTREZGENE
  ENSRNOP00000089730.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000011948.5 UniProtKB/TrEMBL
  ENSRNOT00000103867 ENTREZGENE
  ENSRNOT00000103867.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.505.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS2_SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:84607 UniProtKB/Swiss-Prot
NCBI Gene 84607 ENTREZGENE
PANTHER PTHR10155:SF7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Socs2 PhenoGen
PRINTS SH2DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART SH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SOCS_box UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF158235 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF55550 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC225712
UniProt A0A0H2UHH1_RAT UniProtKB/TrEMBL
  A0A8I6AD64 ENTREZGENE, UniProtKB/TrEMBL
  O88582 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Socs2  suppressor of cytokine signaling 2  Cish2  cytokine inducible SH2-containing protein 2  Symbol and Name updated 1299863 APPROVED
2002-06-10 Cish2  cytokine inducible SH2-containing protein 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process negative regulator of growth hormone (GH) signaling that regulates body growth postnatally and neuronal differentiation during development 1302348
gene_product member of a family of negative regulators of cytokine signalling 634752