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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69423
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Srebf1
Name: sterol regulatory element binding transcription factor 1
Acc ID: CHEBI:6801
Term: metformin
Definition: A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Chemical ID: MESH:D008687
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
multiple interactionsEXP 6480464CTDMetformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 mRNA], Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 protein]

PMID:31100278
multiple interactionsISORGD:694736480464CTD[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein

PMID:28576465
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.