Ctsc (cathepsin C) - Rat Genome Database

Send us a Message

Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Ctsc (cathepsin C) Rattus norvegicus
Symbol: Ctsc
Name: cathepsin C
RGD ID: 2445
Description: Enables several functions, including chaperone binding activity; chloride ion binding activity; and identical protein binding activity. Involved in aging; positive regulation of proteolysis involved in protein catabolic process; and response to organic substance. Located in Golgi apparatus; endoplasmic reticulum; and lysosome. Biomarker of brain ischemia; hypertension; and obesity. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (cathepsin C); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
Previously known as: CATC; Cathepsin C (dipeptidyl peptidase I); cathepsin J; dipeptidyl peptidase 1; dipeptidyl peptidase I; dipeptidyl transferase; dipeptidyl-peptidase 1; dipeptidyl-peptidase I; DPP-I; DPPI
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Is Marker For: Strains:   FHH.BN-(D1Hmgc14-D1Hmgc15)/Mcwi  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21142,028,386 - 142,059,841 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1142,028,392 - 142,060,387 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1149,985,662 - 150,017,065 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01157,162,100 - 157,193,503 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01150,036,027 - 150,067,428 (+)NCBIRnor_WKY
Rnor_6.01151,918,514 - 151,949,979 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,918,571 - 151,949,983 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01158,231,534 - 158,263,124 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41144,629,802 - 144,661,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11144,708,207 - 144,739,589 (+)NCBI
Celera1140,327,884 - 140,359,275 (+)NCBICelera
Cytogenetic Map1q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acetamide  (EXP)
aconitine  (EXP)
acrylamide  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (ISO)
choline  (ISO)
cidofovir anhydrous  (ISO)
ciglitazone  (ISO)
cisplatin  (ISO)
clodronic acid  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
diethylstilbestrol  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
fenofibrate  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
glyphosate  (ISO)
hydrazine  (ISO)
ibuprofen  (EXP,ISO)
ifosfamide  (ISO)
indometacin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
mercury dichloride  (EXP)
metformin  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mifepristone  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nickel dichloride  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (ISO)
phenylephrine  (EXP)
phenylmercury acetate  (ISO)
pirimiphos-methyl  (EXP)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
quercetin  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
Soman  (EXP)
sotorasib  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trametinib  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
XL147  (ISO)
zoledronic acid  (ISO)


References - curated
# Reference Title Reference Citation
1. Gene expression in rats with Barrett's esophagus and esophageal adenocarcinoma induced by gastroduodenoesophageal reflux. Cheng P, etal., World J Gastroenterol. 2005 Sep 7;11(33):5117-22.
2. Increased muscle proteolysis after local trauma mainly reflects macrophage-associated lysosomal proteolysis. Farges MC, etal., Am J Physiol Endocrinol Metab 2002 Feb;282(2):E326-35.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Mutations of the cathepsin C gene are responsible for Papillon-Lefevre syndrome. Hart TC, etal., J Med Genet. 1999 Dec;36(12):881-7.
6. Cathepsin C propeptide interacts with intestinal alkaline phosphatase and heat shock cognate protein 70 in human Caco-2 cells. Hirasaka K, etal., J Physiol Sci. 2008 Apr;58(2):105-11. doi: 10.2170/physiolsci.RP013007. Epub 2008 Mar 1.
7. Molecular cloning of cDNA for rat cathepsin C. Cathepsin C, a cysteine proteinase with an extremely long propeptide. Ishidoh K, etal., J Biol Chem 1991 Sep 5;266(25):16312-7.
8. Dipeptide vinyl sulfones suitable for intracellular inhibition of dipeptidyl peptidase I. Korver GE, etal., Int Immunopharmacol. 2001 Jan;1(1):21-32.
9. Active recombinant rat dipeptidyl aminopeptidase I (cathepsin C) produced using the baculovirus expression system. Lauritzen C, etal., Protein Expr Purif. 1998 Dec;14(3):434-42.
10. Genomics of the periinfarction cortex after focal cerebral ischemia. Lu A, etal., J Cereb Blood Flow Metab. 2003 Jul;23(7):786-810.
11. Synthesis, transport and processing of cathepsin C in Morris hepatoma 7777 cells and rat hepatocytes. Mainferme F, etal., Eur J Biochem. 1985 Nov 15;153(1):211-6.
12. Hydrolase activities increase in the rat aorta with growth and aging but not in liver and kidney. Markle RA Proc Soc Exp Biol Med. 1986 Nov;183(2):169-76.
13. Proteolytic enzymes in ordinary, hyperacute, monocytic and passive transfer forms of experimental allergic encephalomyelitis. Marks N, etal., Brain Res. 1977 Mar 4;123(1):147-57.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Processing and transport of the precursor of cathepsin C during its transfer into lysosomes. Muno D, etal., Arch Biochem Biophys. 1993 Oct;306(1):103-10.
16. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
17. Tetrameric dipeptidyl peptidase I directs substrate specificity by use of the residual pro-part domain. Olsen JG, etal., FEBS Lett. 2001 Oct 12;506(3):201-6.
18. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Importance of the propeptide in the biosynthetic maturation of rat cathepsin C. Santilman V, etal., Eur J Cell Biol 2002 Dec;81(12):654-63.
23. Mutation analysis of the cathepsin C gene in Indian families with Papillon-Lefevre syndrome. Selvaraju V, etal., BMC Med Genet 2003 Jul 12;4(1):5.
24. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
25. [Effect of neonatal nutrition on the enzyme activity of liver lysosomes, adipocytes and thrombocytes in young and old rats] Vasil'ev AV, etal., Vopr Pitan. 1986 Mar-Apr;(2):43-7.
26. Hydrolase activities in the rat aorta. I. Effects of diabetes mellitus and insulin treatment. Wolinsky H, etal., Circ Res. 1978 Jun;42(6):821-31.
27. Hydrolase activities in the rat aorta. II. Effects of hypertension alone and in combination with diabetes mellitus. Wolinsky H, etal., Circ Res. 1978 Jun;42(6):831-9.
Additional References at PubMed
PMID:1515062   PMID:1740150   PMID:8811434   PMID:16502470   PMID:19056867   PMID:19199708   PMID:19946888   PMID:20435891   PMID:23376485   PMID:23533145   PMID:26884336   PMID:28251676  
PMID:28665049   PMID:32302668   PMID:34828301  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.21142,028,386 - 142,059,841 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1142,028,392 - 142,060,387 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1149,985,662 - 150,017,065 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01157,162,100 - 157,193,503 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01150,036,027 - 150,067,428 (+)NCBIRnor_WKY
Rnor_6.01151,918,514 - 151,949,979 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1151,918,571 - 151,949,983 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01158,231,534 - 158,263,124 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41144,629,802 - 144,661,183 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11144,708,207 - 144,739,589 (+)NCBI
Celera1140,327,884 - 140,359,275 (+)NCBICelera
Cytogenetic Map1q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381188,293,592 - 88,337,736 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1188,265,069 - 88,359,684 (-)EnsemblGRCh38hg38GRCh38
GRCh371188,026,760 - 88,070,904 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361187,666,408 - 87,710,586 (-)NCBINCBI36Build 36hg18NCBI36
Build 341187,698,901 - 87,710,586NCBI
Celera1186,561,173 - 86,605,363 (+)NCBICelera
Cytogenetic Map11q14.2NCBI
HuRef1184,265,651 - 84,309,838 (-)NCBIHuRef
CHM1_11187,909,527 - 87,953,700 (-)NCBICHM1_1
T2T-CHM13v2.01188,212,614 - 88,256,755 (-)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39787,927,220 - 87,965,069 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl787,927,293 - 87,960,096 (+)EnsemblGRCm39 Ensembl
GRCm38788,278,024 - 88,315,861 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl788,278,085 - 88,310,888 (+)EnsemblGRCm38mm10GRCm38
MGSCv37795,426,603 - 95,459,385 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36788,153,327 - 88,186,080 (+)NCBIMGSCv36mm8
Celera785,627,464 - 85,661,039 (+)NCBICelera
Cytogenetic Map7D3NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554145,062,355 - 5,092,154 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554145,062,355 - 5,092,631 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.11186,890,010 - 86,933,847 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1186,890,010 - 86,933,847 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01183,299,827 - 83,345,383 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12111,659,296 - 11,692,957 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2111,659,292 - 11,692,816 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2111,517,038 - 11,552,914 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02111,838,431 - 11,874,146 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2111,838,429 - 11,876,897 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12111,627,285 - 11,662,982 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02111,697,940 - 11,733,812 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02111,752,070 - 11,787,980 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440494774,101,638 - 74,140,957 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049367361,201,343 - 1,240,311 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl921,722,036 - 21,761,516 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1921,726,628 - 21,761,796 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2924,081,771 - 24,116,596 (-)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1179,426,556 - 79,468,464 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl179,426,549 - 79,468,340 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604346,251,030 - 46,291,563 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_0046248451,783,918 - 1,815,981 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248451,783,807 - 1,816,471 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Ctsc
93 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:366
Count of miRNA genes:212
Interacting mature miRNAs:252
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132356093162846471Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)132737458199368955Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)148963584144267916Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149393172159356837Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149393289199050459Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)157336763151090257Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)181591954219808434Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)187580395150700247Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)190508614173018436Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)190508614180359386Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)190664883143200202Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)192948896144267916Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194494440172949803Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194494440181830018Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)194494440198211706Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)194494440198324465Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)194642722214537671Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)199267916144267916Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)199267916144267916Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1100357752183970443Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1100979852145979852Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1102168504147168504Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1102268556147268556Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1102813953151162766Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1102813953201278233Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1102813953201278233Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1102813953218753816Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1103111621148111621Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1103111621148111621Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1106047847151047847Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1115540693185145286Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1115540693238914717Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1115585465172949803Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118608292241799120Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1118944747163944747Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1118944897199050459Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121006655166006655Rat
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1121767634166767634Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1121833674166833674Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350408181759564Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1123350408182418476Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1123350408182418476Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1123350408182418476Rat
631549Bp89Blood pressure QTL 895.7arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123350581201284552Rat
631570Bp94Blood pressure QTL 940.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1123479780142990467Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501168883176Rat
9685799Bp375Blood pressure QTL 375arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1125611501170611501Rat
9685802Bp376Blood pressure QTL 376arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1126540680171540680Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1130636910175636910Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1131763437159756369Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1133680936178680936Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1136745990163747690Rat
71118Thym1Thymus enlargement QTL 110.170.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
724550Thym3Thymus enlargement QTL 37.820.001thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1136829932181829932Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1136830018181830018Rat

Markers in Region
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,060,161 - 142,060,354 (+)MAPPERmRatBN7.2
Rnor_6.01151,950,300 - 151,950,492NCBIRnor6.0
Rnor_5.01158,263,445 - 158,263,637UniSTSRnor5.0
RGSC_v3.41144,661,504 - 144,661,696UniSTSRGSC3.4
Celera1140,359,596 - 140,359,788UniSTS
RH 3.4 Map11115.5UniSTS
Cytogenetic Map1q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,039,595 - 142,039,775 (+)MAPPERmRatBN7.2
Rnor_6.01151,929,734 - 151,929,913NCBIRnor6.0
Rnor_5.01158,242,670 - 158,242,849UniSTSRnor5.0
RGSC_v3.41144,640,938 - 144,641,117UniSTSRGSC3.4
Celera1140,339,020 - 140,339,199UniSTS
RH 3.4 Map11115.5UniSTS
Cytogenetic Map1q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,051,346 - 142,051,511 (+)MAPPERmRatBN7.2
Rnor_6.01151,941,485 - 151,941,649NCBIRnor6.0
Rnor_5.01158,254,421 - 158,254,585UniSTSRnor5.0
RGSC_v3.41144,652,689 - 144,652,853UniSTSRGSC3.4
Celera1140,350,781 - 140,350,945UniSTS
RH 3.4 Map11115.1UniSTS
Cytogenetic Map1q32UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21142,041,144 - 142,041,234 (+)MAPPERmRatBN7.2
Rnor_6.01151,931,283 - 151,931,372NCBIRnor6.0
Rnor_5.01158,244,219 - 158,244,308UniSTSRnor5.0
RGSC_v3.41144,642,487 - 144,642,576UniSTSRGSC3.4
Celera1140,340,579 - 140,340,668UniSTS
RH 3.4 Map11123.1UniSTS
Cytogenetic Map1q32UniSTS

Related Rat Strains
The following Strains have been annotated to Ctsc


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 57 41 19 41 8 11 17 35 34 11 8
Low 57 7
Below cutoff


Reference Sequences
RefSeq Acc Id: ENSRNOT00000022342   ⟹   ENSRNOP00000022342
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1142,028,392 - 142,060,387 (+)Ensembl
Rnor_6.0 Ensembl1151,918,571 - 151,949,983 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097085   ⟹   ENSRNOP00000085136
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1142,028,392 - 142,037,751 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000108529   ⟹   ENSRNOP00000084170
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1142,028,392 - 142,036,904 (+)Ensembl
RefSeq Acc Id: NM_017097   ⟹   NP_058793
Rat AssemblyChrPosition (strand)Source
mRatBN7.21142,028,460 - 142,059,841 (+)NCBI
Rnor_6.01151,918,598 - 151,949,979 (+)NCBI
Rnor_5.01158,231,534 - 158,263,124 (+)NCBI
RGSC_v3.41144,629,802 - 144,661,183 (+)RGD
Celera1140,327,884 - 140,359,275 (+)RGD
RefSeq Acc Id: XM_008759637   ⟹   XP_008757859
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21142,028,386 - 142,041,540 (+)NCBI
Rnor_6.01151,918,514 - 151,932,554 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_058793   ⟸   NM_017097
- Peptide Label: precursor
- UniProtKB: P80068 (UniProtKB/Swiss-Prot),   P80067 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008757859   ⟸   XM_008759637
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZG1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000022342   ⟸   ENSRNOT00000022342
RefSeq Acc Id: ENSRNOP00000084170   ⟸   ENSRNOT00000108529
RefSeq Acc Id: ENSRNOP00000085136   ⟸   ENSRNOT00000097085
Protein Domains

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P80067-F1-model_v2 AlphaFold P80067 1-462 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13690178
Promoter ID:EPDNEW_R703
Type:initiation region
Description:cathepsin C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.01151,918,581 - 151,918,641EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2445 AgrOrtholog
BioCyc Gene G2FUF-58577 BioCyc
Ensembl Genes ENSRNOG00000016496 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000022342 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000084170.1 UniProtKB/TrEMBL
  ENSRNOP00000085136.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000022342 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000097085.1 UniProtKB/TrEMBL
  ENSRNOT00000108529.1 UniProtKB/TrEMBL
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CatC UniProtKB/Swiss-Prot
  CathepsinC_exc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CathepsinC_exc_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/Swiss-Prot
  Pept_asp_AS UniProtKB/Swiss-Prot
  Pept_cys_AS UniProtKB/Swiss-Prot
  Pept_his_AS UniProtKB/Swiss-Prot
  Peptidase_C1A_C UniProtKB/Swiss-Prot
KEGG Report rno:25423 UniProtKB/Swiss-Prot
Pfam CathepsinC_exc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_C1 UniProtKB/Swiss-Prot
PhenoGen Ctsc PhenoGen
SMART Pept_C1 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54001 UniProtKB/Swiss-Prot
  SSF75001 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC217945
UniProt Secondary P80068 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Ctsc  cathepsin C    Cathepsin C (dipeptidyl peptidase I)  Name updated 625702 APPROVED
2002-06-10 Ctsc  Cathepsin C (dipeptidyl peptidase I)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease mutation of the human homolog is associated with Papillon-Lefevre syndrome 728224