Ube2b (ubiquitin-conjugating enzyme E2B) - Rat Genome Database

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Gene: Ube2b (ubiquitin-conjugating enzyme E2B) Rattus norvegicus
Analyze
Symbol: Ube2b
Name: ubiquitin-conjugating enzyme E2B
RGD ID: 708345
Description: Predicted to enable ubiquitin conjugating enzyme activity and ubiquitin protein ligase binding activity. Involved in cellular response to insulin stimulus; response to hypoxia; and ubiquitin-dependent protein catabolic process. Predicted to be located in chromosome; cytoplasm; and nucleus. Predicted to be part of HULC complex. Orthologous to human UBE2B (ubiquitin conjugating enzyme E2 B); PARTICIPATES IN ubiquitin/proteasome degradation pathway; INTERACTS WITH (+)-schisandrin B; 1,3-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: E2 ubiquitin-conjugating enzyme B; E2(14k); HR6B; LOC103694902; LOC81816; RAD6 homolog B; ubiquitin carrier protein B; ubiquitin conjugating enzyme; ubiquitin-conjugating enzyme E2 B; ubiquitin-conjugating enzyme E2(14k); ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae); ubiquitin-conjugating enzyme E2B, RAD6 homolog; ubiquitin-conjugating enzyme E2B, RAD6 homolog (S. cerevisiae); ubiquitin-conjugating enzyme E2B, RAD6 homology; ubiquitin-conjugating enzyme E2B, RAD6 homology (S. cerevisiae); ubiquitin-protein ligase B
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,749,365 - 36,764,335 (-)NCBIGRCr8
mRatBN7.21036,248,434 - 36,263,379 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,248,438 - 36,264,665 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1040,942,877 - 40,957,457 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,432,847 - 40,447,427 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,936,569 - 35,951,149 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,439,947 - 37,454,867 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,441,284 - 37,455,022 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,213,057 - 37,229,080 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,509,322 - 37,523,900 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11037,516,863 - 37,530,245 (-)NCBI
Celera1035,603,474 - 35,618,052 (-)NCBICelera
Cytogenetic Map10q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP)
17alpha-ethynylestradiol  (ISO)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
acetylsalicylic acid  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
berberine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
butyric acid  (EXP)
cadmium dichloride  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
choline  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
dicrotophos  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gedunin  (ISO)
gentamycin  (EXP)
glafenine  (EXP)
ibuprofen  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead(0)  (ISO)
lipopolysaccharide  (EXP,ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
monocrotaline  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
ranitidine  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (ISO)
cytoplasm  (IEA,ISO)
HULC complex  (IBA,IEA,ISO,ISS)
nucleus  (IEA,ISO)
plasma membrane  (IEA)
replication fork  (IEA,ISO)
XY body  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. UDP-glucuronosyltransferase isoforms catalyzing glucuronidation of hydroxy-polychlorinated biphenyls in rat. Daidoji T, etal., Drug Metab Dispos. 2005 Oct;33(10):1466-76. Epub 2005 Jul 8.
2. Splice-site mutations: a novel genetic mechanism of Crigler-Najjar syndrome type 1. Gantla S, etal., Am J Hum Genet. 1998 Mar;62(3):585-92.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. Atrophy, hypertrophy, and hypoxemia induce transcriptional regulators of the ubiquitin proteasome system in the rat heart. Razeghi P, etal., Biochem Biophys Res Commun. 2006 Apr 7;342(2):361-4. Epub 2006 Feb 8.
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats. Seppen J, etal., Mol Ther. 2006 Jun;13(6):1085-92. Epub 2006 Apr 3.
11. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
12. 14-kDa ubiquitin-conjugating enzyme: structure of the rat gene and regulation upon fasting and by insulin. Wing SS and Banville D, Am J Physiol 1994 Jul;267(1 Pt 1):E39-48.
13. A rabbit reticulocyte ubiquitin carrier protein that supports ubiquitin-dependent proteolysis (E214k) is homologous to the yeast DNA repair gene RAD6. Wing SS, etal., J Biol Chem 1992 Apr 5;267(10):6495-501.
Additional References at PubMed
PMID:1717990   PMID:8889548   PMID:9922113   PMID:10373550   PMID:10908344   PMID:12556476   PMID:12672659   PMID:14585983   PMID:14981545   PMID:15169909   PMID:15383616   PMID:15489334  
PMID:15657431   PMID:15946855   PMID:17010969   PMID:17462990   PMID:17488778   PMID:18339854   PMID:18363965   PMID:19123975   PMID:19410543   PMID:20061386   PMID:20080676   PMID:31576007  
PMID:34632937  


Genomics

Comparative Map Data
Ube2b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81036,749,365 - 36,764,335 (-)NCBIGRCr8
mRatBN7.21036,248,434 - 36,263,379 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1036,248,438 - 36,264,665 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1040,942,877 - 40,957,457 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01040,432,847 - 40,447,427 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01035,936,569 - 35,951,149 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01037,439,947 - 37,454,867 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1037,441,284 - 37,455,022 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01037,213,057 - 37,229,080 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41037,509,322 - 37,523,900 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11037,516,863 - 37,530,245 (-)NCBI
Celera1035,603,474 - 35,618,052 (-)NCBICelera
Cytogenetic Map10q22NCBI
UBE2B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385134,371,569 - 134,392,108 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5134,371,184 - 134,392,108 (+)EnsemblGRCh38hg38GRCh38
GRCh375133,707,260 - 133,727,799 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365133,734,769 - 133,755,698 (+)NCBINCBI36Build 36hg18NCBI36
Build 345133,734,768 - 133,755,698NCBI
Celera5129,830,646 - 129,851,595 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5128,891,659 - 128,912,617 (+)NCBIHuRef
CHM1_15133,139,494 - 133,160,408 (+)NCBICHM1_1
T2T-CHM13v2.05134,895,355 - 134,915,908 (+)NCBIT2T-CHM13v2.0
Ube2b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391151,875,965 - 51,894,972 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1151,876,324 - 51,891,589 (-)EnsemblGRCm39 Ensembl
GRCm381151,985,138 - 52,004,145 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1151,985,497 - 52,000,762 (-)EnsemblGRCm38mm10GRCm38
MGSCv371151,798,648 - 51,813,968 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361151,828,985 - 51,843,810 (-)NCBIMGSCv36mm8
Celera1156,553,448 - 56,568,767 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1131.82NCBI
Ube2b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554085,552,619 - 5,572,145 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554085,552,619 - 5,572,145 (+)NCBIChiLan1.0ChiLan1.0
UBE2B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24129,669,779 - 129,689,993 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15127,809,653 - 127,829,555 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05129,775,011 - 129,794,853 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15135,925,217 - 135,944,609 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5135,925,217 - 135,944,609 (+)Ensemblpanpan1.1panPan2
UBE2B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11122,523,671 - 22,541,473 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1122,525,051 - 22,540,388 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1121,269,251 - 21,287,230 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01123,325,044 - 23,343,019 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1123,326,331 - 23,345,713 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11122,024,744 - 22,042,221 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01121,890,257 - 21,907,725 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01122,532,474 - 22,550,185 (+)NCBIUU_Cfam_GSD_1.0
Ube2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213113,888,593 - 113,911,224 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936647891,996 - 911,033 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936647891,357 - 913,963 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBE2B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2136,652,785 - 136,667,949 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12136,652,764 - 136,667,213 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22142,228,179 - 142,237,960 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12337,180,011 - 37,199,250 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2337,180,424 - 37,198,064 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603440,733,276 - 40,753,205 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ube2b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473337,891,280 - 37,906,066 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473337,890,350 - 37,907,846 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ube2b
40 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:817
Count of miRNA genes:314
Interacting mature miRNAs:403
Transcripts:ENSRNOT00000016742
Prediction methods:Microtar, Miranda, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103539245763642539Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103129743976297439Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103449055945579777Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat
1554317Bmd4Bone mineral density QTL 49.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)101981604299406971Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101816784163167841Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102132980561345413Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102845313673453136Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103539226764155584Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102929950464155584Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102694462871944628Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101448701189062041Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109658275104670812Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10538701450387014Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
10402859Bp381Blood pressure QTL 3810.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014487011107057807Rat
6893352Bw100Body weight QTL 1000.330.6body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102242750090627625Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10615418273453136Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10538701450387014Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)10538701450387014Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10180676123Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101502851360430477Rat
6893350Bw99Body weight QTL 990.870.16body mass (VT:0001259)body weight (CMO:0000012)11590666560906665Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102652195761345413Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10538701450387014Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)1029299504107211142Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)101960648364606483Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138328221Rat
631531Iresp2Immunoglobin response QTL26.3blood immunoglobulin E amount (VT:0002492)serum immunoglobulin E level (CMO:0002101)102291826836400810Rat
1354614Hpcl1Hepatic cholesterol level QTL 13.3liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)103539226751793994Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101790711351786432Rat
1576319Cia29Collagen induced arthritis QTL 29joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103397392178973921Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142315980Rat
1600371Mcs21Mammary carcinoma susceptibility QTL 213mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)102887565052200160Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014487011104060283Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101147401056474010Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103122402675632053Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10635789696121100Rat
2292441Bp308Blood pressure QTL 308arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102760646872606468Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)101960648364606483Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102652195798952741Rat

Markers in Region
RH140161  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,256,687 - 36,256,896 (+)MAPPERmRatBN7.2
Rnor_6.01037,448,201 - 37,448,409NCBIRnor6.0
Rnor_5.01037,221,311 - 37,221,519UniSTSRnor5.0
RGSC_v3.41037,517,576 - 37,517,784UniSTSRGSC3.4
Celera1035,611,728 - 35,611,936UniSTS
RH 3.4 Map10387.7UniSTS
Cytogenetic Map10q22UniSTS
RH141513  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21036,249,016 - 36,249,232 (+)MAPPERmRatBN7.2
Rnor_6.01037,440,530 - 37,440,745NCBIRnor6.0
Rnor_5.01037,213,640 - 37,213,855UniSTSRnor5.0
RGSC_v3.41037,509,905 - 37,510,120UniSTSRGSC3.4
Celera1035,604,057 - 35,604,272UniSTS
RH 3.4 Map10387.4UniSTS
Cytogenetic Map10q22UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000016742   ⟹   ENSRNOP00000016742
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1037,441,284 - 37,455,022 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091694   ⟹   ENSRNOP00000070793
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,248,438 - 36,264,665 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106084   ⟹   ENSRNOP00000095094
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,248,438 - 36,264,665 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000106887   ⟹   ENSRNOP00000078841
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1036,248,438 - 36,263,008 (-)Ensembl
RefSeq Acc Id: NM_031138   ⟹   NP_112400
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,749,365 - 36,763,943 (-)NCBI
mRatBN7.21036,248,434 - 36,263,012 (-)NCBI
Rnor_6.01037,439,947 - 37,454,525 (-)NCBI
Rnor_5.01037,213,057 - 37,229,080 (-)NCBI
RGSC_v3.41037,509,322 - 37,523,900 (-)RGD
Celera1035,603,474 - 35,618,052 (-)RGD
Sequence:
RefSeq Acc Id: XM_006246343   ⟹   XP_006246405
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,749,767 - 36,764,335 (-)NCBI
mRatBN7.21036,248,437 - 36,263,374 (-)NCBI
Rnor_6.01037,440,348 - 37,454,867 (-)NCBI
Rnor_5.01037,213,057 - 37,229,080 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039086941   ⟹   XP_038942869
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81036,749,767 - 36,764,312 (-)NCBI
mRatBN7.21036,248,437 - 36,263,379 (-)NCBI
RefSeq Acc Id: NP_112400   ⟸   NM_031138
- UniProtKB: P63149 (UniProtKB/Swiss-Prot),   A6HE85 (UniProtKB/TrEMBL),   A0A0G2JYU5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246405   ⟸   XM_006246343
- Peptide Label: isoform X1
- UniProtKB: A6HE84 (UniProtKB/TrEMBL),   A0A8I6ANY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016742   ⟸   ENSRNOT00000016742
RefSeq Acc Id: XP_038942869   ⟸   XM_039086941
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000070793   ⟸   ENSRNOT00000091694
Ensembl Acc Id: ENSRNOP00000078841   ⟸   ENSRNOT00000106887
Ensembl Acc Id: ENSRNOP00000095094   ⟸   ENSRNOT00000106084
Protein Domains
UBC core

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P63149-F1-model_v2 AlphaFold P63149 1-152 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708345 AgrOrtholog
BioCyc Gene G2FUF-25179 BioCyc
BioCyc Pathway PWY-7511 [protein ubiquitination] BioCyc
BioCyc Pathway Image PWY-7511 BioCyc
Ensembl Genes ENSRNOG00000005064 Ensembl
  ENSRNOG00000059348 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000091694.2 UniProtKB/TrEMBL
  ENSRNOT00000106084.1 UniProtKB/TrEMBL
  ENSRNOT00000106887.1 UniProtKB/TrEMBL
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7103580 IMAGE-MGC_LOAD
InterPro Ub_conjugating_enzyme UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-conjugat_E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-conjugating_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81816 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91645 IMAGE-MGC_LOAD
NCBI Gene 81816 ENTREZGENE
PANTHER UBIQUITIN-CONJUGATING ENZYME E2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN-CONJUGATING ENZYME E2 B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN-CONJUGATING ENZYME E2-17 KDA UniProtKB/TrEMBL
Pfam UQ_con UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ube2b PhenoGen
PROSITE UBIQUITIN_CONJUGAT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  UBIQUITIN_CONJUGAT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005064 RatGTEx
  ENSRNOG00000059348 RatGTEx
SMART UBCc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54495 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JYU5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZM78_RAT UniProtKB/TrEMBL
  A0A8I6ANY2 ENTREZGENE, UniProtKB/TrEMBL
  A6HE83_RAT UniProtKB/TrEMBL
  A6HE84 ENTREZGENE, UniProtKB/TrEMBL
  A6HE85 ENTREZGENE, UniProtKB/TrEMBL
  A6HE86_RAT UniProtKB/TrEMBL
  P63149 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P23567 UniProtKB/Swiss-Prot
  Q9D0J6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ube2b  ubiquitin-conjugating enzyme E2B  LOC103694902  ubiquitin-conjugating enzyme E2 B  Data merged from RGD:9295755 737654 PROVISIONAL
2014-08-25 LOC103694902  ubiquitin-conjugating enzyme E2 B      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-06-13 Ube2b  ubiquitin-conjugating enzyme E2B  Ube2b  ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-19 Ube2b  ubiquitin-conjugating enzyme E2B (RAD6 homolog, S. cerevisiae)  Ube2b  ubiquitin-conjugating enzyme E2B, RAD6 homology (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-07 Ube2b  ubiquitin-conjugating enzyme E2B, RAD6 homology (S. cerevisiae)  Ube2b  ubiquitin-conjugating enzyme E2B, RAD6 homolog (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Ube2b  ubiquitin-conjugating enzyme E2B, RAD6 homolog (S. cerevisiae)  LOC81816  ubiquitin conjugating enzyme  Symbol and Name updated 1299863 APPROVED