Mef2a (myocyte enhancer factor 2a) - Rat Genome Database
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Gene: Mef2a (myocyte enhancer factor 2a) Rattus norvegicus
Analyze
Symbol: Mef2a
Name: myocyte enhancer factor 2a
RGD ID: 1359360
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including cellular response to calcium ion; cellular response to glucose stimulus; and dendrite morphogenesis. Localizes to nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human MEF2A (myocyte enhancer factor 2A); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2-amino-2-deoxy-D-glucopyranose.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC309957; myocyte-specific enhancer factor 2A; similar to myocyte enhancer factor 2C
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21120,847,874 - 120,982,488 (-)NCBI
Rnor_6.0 Ensembl1128,209,971 - 128,341,263 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01128,207,715 - 128,341,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01129,273,893 - 129,407,071 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11122,128,377 - 122,183,406 (-)NCBI
Celera1113,052,879 - 113,157,227 (-)NCBICelera
Cytogenetic Map1q22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4-phenylbutyric acid  (EXP,ISO)
5-azacytidine  (ISO)
acrolein  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
alpha-pinene  (ISO)
benzene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP,ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
carbamazepine  (ISO)
chloroprene  (EXP)
choline  (ISO)
cocaine  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
dantrolene  (EXP)
dibutyl phthalate  (EXP)
diclofenac  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enniatin  (EXP)
Enterolactone  (ISO)
ethanol  (ISO)
folic acid  (ISO)
geraniol  (ISO)
L-methionine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
metformin  (ISO)
methylmercury chloride  (ISO)
metoprolol  (EXP)
nickel atom  (ISO)
nitric oxide  (ISO)
oxytocin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
propiconazole  (ISO)
raloxifene  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP)
succimer  (ISO)
sulfates  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP,ISO)
theophylline  (ISO)
topotecan  (EXP)
torcetrapib  (ISO)
trichostatin A  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromatin  (IBA,IEA,ISO)
cytosol  (IEA,ISO)
nucleoplasm  (IEA,ISO,TAS)
nucleus  (IDA,IEA,ISO,ISS)
transcription regulator complex  (IEA,ISO)

References

Additional References at PubMed
PMID:7760790   PMID:8096811   PMID:8900141   PMID:9013788   PMID:9430690   PMID:9738004   PMID:9858528   PMID:10458488   PMID:10748098   PMID:10835359   PMID:11160896   PMID:12097321  
PMID:12130539   PMID:12379849   PMID:12826611   PMID:15132737   PMID:15466416   PMID:15491989   PMID:15735306   PMID:16024167   PMID:16043483   PMID:16407236   PMID:16484497   PMID:16985263  
PMID:17431507   PMID:17630987   PMID:17785444   PMID:17855618   PMID:18198354   PMID:19197241   PMID:19362076   PMID:20363751   PMID:20399744   PMID:20590529   PMID:20833138   PMID:21379568  
PMID:21468593   PMID:21724844   PMID:22194471   PMID:22622902   PMID:23261540   PMID:23349925   PMID:23424201   PMID:23486945   PMID:24161931   PMID:25089838   PMID:25147362   PMID:28263745  
PMID:28473466   PMID:29588465   PMID:29606596   PMID:29678571   PMID:29783071   PMID:29928931  


Genomics

Comparative Map Data
Mef2a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21120,847,874 - 120,982,488 (-)NCBI
Rnor_6.0 Ensembl1128,209,971 - 128,341,263 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01128,207,715 - 128,341,681 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01129,273,893 - 129,407,071 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.11122,128,377 - 122,183,406 (-)NCBI
Celera1113,052,879 - 113,157,227 (-)NCBICelera
Cytogenetic Map1q22NCBI
MEF2A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1599,565,417 - 99,716,466 (+)EnsemblGRCh38hg38GRCh38
GRCh381599,565,417 - 99,716,488 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3715100,105,622 - 100,256,693 (+)NCBIGRCh37GRCh37hg19GRCh37
GRCh3715100,106,133 - 100,256,688 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361597,956,185 - 98,071,524 (+)NCBINCBI36hg18NCBI36
Build 341597,956,184 - 98,071,524NCBI
Celera1576,525,015 - 76,675,549 (+)NCBI
Cytogenetic Map15q26.3NCBI
HuRef1576,235,794 - 76,386,442 (+)NCBIHuRef
CHM1_11599,947,526 - 100,098,006 (+)NCBICHM1_1
Mef2a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39766,880,911 - 67,026,435 (-)NCBIGRCm39mm39
GRCm38767,231,163 - 67,376,456 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl767,231,163 - 67,372,858 (-)EnsemblGRCm38mm10GRCm38
MGSCv37774,378,710 - 74,517,744 (-)NCBIGRCm37mm9NCBIm37
MGSCv36767,112,774 - 67,251,808 (-)NCBImm8
Celera764,692,674 - 64,806,488 (-)NCBICelera
Cytogenetic Map7CNCBI
cM Map736.72NCBI
Mef2a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541626,953,798 - 27,051,171 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541626,926,753 - 27,051,171 (+)NCBIChiLan1.0ChiLan1.0
MEF2A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11597,428,808 - 97,579,092 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1597,428,744 - 97,579,092 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01578,246,439 - 78,396,720 (+)NCBIMhudiblu_PPA_v0panPan3
MEF2A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl341,015,713 - 41,179,448 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1341,012,103 - 41,177,588 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Mef2a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364833,837,891 - 3,982,334 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEF2A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1138,341,153 - 138,511,311 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11138,398,270 - 138,508,639 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21154,615,130 - 154,689,503 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MEF2A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12918,150,315 - 18,312,975 (+)NCBI
ChlSab1.1 Ensembl2918,150,854 - 18,309,247 (+)Ensembl
Mef2a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247684,701,734 - 4,852,833 (-)NCBI

Position Markers
BF390775  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01128,222,938 - 128,223,087NCBIRnor6.0
Rnor_5.01129,288,675 - 129,288,824UniSTSRnor5.0
Celera1113,065,868 - 113,066,017UniSTS
RH 3.4 Map11466.59UniSTS
Cytogenetic Map1q22UniSTS
AU048441  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01128,216,130 - 128,216,288NCBIRnor6.0
Rnor_5.01129,282,308 - 129,282,466UniSTSRnor5.0
Celera1113,059,044 - 113,059,202UniSTS
Cytogenetic Map1q22UniSTS
Mef2a  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01128,242,704 - 128,242,837NCBIRnor6.0
Rnor_5.01129,308,375 - 129,308,508UniSTSRnor5.0
Celera1113,085,480 - 113,085,613UniSTS
Cytogenetic Map1q22UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)125951907130917265Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134993530173445086Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)135377692217372257Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)149147799156446783Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)149578577169852184Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)149578693217054291Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)158354072161711996Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)182788437239853971Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)183502376128502376Rat
61344Bp29Blood pressure QTL 297.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)185779320130779320Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)185917265130917265Rat
4889494Scort2Serum corticosterone level QTL 24.2blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)186776571131776571Rat
724529Cm16Cardiac mass QTL 162.7heart mass (VT:0007028)calculated heart weight (CMO:0000073)190804143161321256Rat
738022Anxrr13Anxiety related response QTL 134.60.00039locomotor behavior trait (VT:0001392)number of 20 x 20 cm floor squares crossed into, out of or within a discrete space in an experimental apparatus (CMO:0001514)191093646136093646Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)194201400184846632Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)194201400197187904Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)194225372130917265Rat
1300153Bp171Blood pressure QTL 1713.37arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)194364073153076991Rat
724567Tcas6Tongue tumor susceptibility QTL 66.85tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)195304961156446783Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)199983293188289386Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)199983293198656062Rat
1331749Hrtrt11Heart rate QTL 112.973heart pumping trait (VT:2000009)heart rate (CMO:0000002)199983293216213510Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)199983293216325819Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100131562236763528Rat
2293142Bp314Blood pressure QTL 314arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1100354344145354344Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1106002252202571904Rat
61370Mcs3Mammary carcinoma susceptibility QTL 32.15mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1108057233167517487Rat
1641897Alcrsp1Alcohol response QTL 1response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1108417193153417193Rat
2317833Alcrsp19Alcohol response QTL 1912.40.001response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)1108417193153417193Rat
1354623Rf46Renal function QTL 463.8blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)1108986301161784422Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1108986301219232156Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1108986301219232156Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1108986301238830534Rat
2303591Gluco41Glucose level QTL 412blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1109634374154634374Rat
9590300Scort16Serum corticosterone level QTL 164.390.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1110620749155620749Rat
8694370Bw154Body weight QTL 1548.910.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)1110620749155620749Rat
61399Tcat1Tongue tumor resistance QTL 13.3tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 5 mm (CMO:0001879)1111446783156446783Rat
61346Rf2Renal disease susceptibility QTL 23.7urine protein amount (VT:0005160)urine protein level (CMO:0000591)1111446783156446783Rat
631569Bp93Blood pressure QTL 930.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1113593576129209407Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1113593576158593576Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1122614824201146953Rat
7794788Mcs32Mammary carcinoma susceptibility QTL 322.61mammary gland integrity trait (VT:0010552)mammary tumor incidence/prevalence measurement (CMO:0000946)1122614824262664716Rat
2313060Bss71Bone structure and strength QTL 712.60.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1124090312169090312Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1124603592188289386Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1125875758262433692Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1126240667217054291Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:898
Count of miRNA genes:222
Interacting mature miRNAs:289
Transcripts:ENSRNOT00000070864, ENSRNOT00000072915
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 42 36 20 19 20 8 10 74 35 38 11 8
Low 1 21 21 21 1 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000070864   ⟹   ENSRNOP00000065122
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1128,211,192 - 128,341,240 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000072915   ⟹   ENSRNOP00000064552
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1128,209,971 - 128,341,263 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000084946   ⟹   ENSRNOP00000068554
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1128,211,391 - 128,287,151 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000089723   ⟹   ENSRNOP00000068690
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1128,211,391 - 128,287,151 (-)Ensembl
RefSeq Acc Id: NM_001014035   ⟹   NP_001014057
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21120,850,123 - 120,981,960 (-)NCBI
Rnor_6.01128,209,964 - 128,341,263 (-)NCBI
Rnor_5.01129,273,893 - 129,407,071 (-)NCBI
Celera1113,052,879 - 113,157,227 (-)RGD
Sequence:
RefSeq Acc Id: XM_008759541   ⟹   XP_008757763
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21120,847,874 - 120,982,472 (-)NCBI
Rnor_6.01128,207,715 - 128,341,681 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008759542   ⟹   XP_008757764
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01128,207,715 - 128,341,678 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017589308   ⟹   XP_017444797
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01128,211,391 - 128,341,680 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039080825   ⟹   XP_038936753
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21120,847,874 - 120,982,484 (-)NCBI
RefSeq Acc Id: XM_039080830   ⟹   XP_038936758
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21120,851,550 - 120,981,723 (-)NCBI
RefSeq Acc Id: XM_039080833   ⟹   XP_038936761
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21120,851,550 - 120,982,488 (-)NCBI
RefSeq Acc Id: XM_039080839   ⟹   XP_038936767
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21120,847,874 - 120,982,481 (-)NCBI
RefSeq Acc Id: XM_039080843   ⟹   XP_038936771
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21120,847,874 - 120,981,715 (-)NCBI
RefSeq Acc Id: XM_039080850   ⟹   XP_038936778
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21120,847,874 - 120,982,484 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001014057   ⟸   NM_001014035
- UniProtKB: Q2MJT0 (UniProtKB/Swiss-Prot),   A0A0G2JSZ4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757763   ⟸   XM_008759541
- Peptide Label: isoform X3
- UniProtKB: M0R6R7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008757764   ⟸   XM_008759542
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_017444797   ⟸   XM_017589308
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000065122   ⟸   ENSRNOT00000070864
RefSeq Acc Id: ENSRNOP00000064552   ⟸   ENSRNOT00000072915
RefSeq Acc Id: ENSRNOP00000068554   ⟸   ENSRNOT00000084946
RefSeq Acc Id: ENSRNOP00000068690   ⟸   ENSRNOT00000089723
RefSeq Acc Id: XP_038936778   ⟸   XM_039080850
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038936753   ⟸   XM_039080825
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936767   ⟸   XM_039080839
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038936771   ⟸   XM_039080843
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038936761   ⟸   XM_039080833
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936758   ⟸   XM_039080830
- Peptide Label: isoform X1
Protein Domains
MADS-box

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690107
Promoter ID:EPDNEW_R631
Type:multiple initiation site
Name:Mef2a_1
Description:myocyte enhancer factor 2a
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01128,341,272 - 128,341,332EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359360 AgrOrtholog
Ensembl Genes ENSRNOG00000047756 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000064552 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000065122 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000068554 UniProtKB/TrEMBL
  ENSRNOP00000068690 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000070864 UniProtKB/TrEMBL
  ENSRNOT00000072915 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000084946 UniProtKB/TrEMBL
  ENSRNOT00000089723 UniProtKB/TrEMBL
Gene3D-CATH 3.40.1810.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7111112 IMAGE-MGC_LOAD
InterPro HJURP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MADS_MEF2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_MADSbox UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TF_MADSbox_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:309957 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93837 IMAGE-MGC_LOAD
NCBI Gene 309957 ENTREZGENE
Pfam HJURP_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SRF-TF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mef2a PhenoGen
PRINTS MADSDOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE MADS_BOX_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MADS_BOX_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART MADS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55455 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JSZ4 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2JT35_RAT UniProtKB/TrEMBL
  A0A0G2JTF4_RAT UniProtKB/TrEMBL
  D8X2M2_RAT UniProtKB/TrEMBL
  M0R6R7 ENTREZGENE, UniProtKB/TrEMBL
  MEF2A_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q66HD7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-12 Mef2a   myocyte enhancer factor 2a  LOC309957  similar to myocyte enhancer factor 2C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-29 LOC309957  similar to myocyte enhancer factor 2C      Symbol and Name status set to provisional 70820 PROVISIONAL