Gene: Mef2a (myocyte enhancer factor 2a) Rattus norvegicus
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Symbol:
Mef2a
Name:
myocyte enhancer factor 2a
RGD ID:
1359360
Description:
Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including cellular response to calcium ion; cellular response to glucose stimulus; and dendrite morphogenesis. Localizes to nucleus. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human MEF2A (myocyte enhancer factor 2A); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2-amino-2-deoxy-D-glucopyranose.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
LOC309957; myocyte-specific enhancer factor 2A; similar to myocyte enhancer factor 2C
Orthologs:
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 1 128,207,715 - 128,341,681 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 1 128,209,971 - 128,341,263 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 1 129,273,893 - 129,407,071 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.1 1 122,128,377 - 122,183,406 (-) NCBI Celera 1 113,052,879 - 113,157,227 (-) NCBI Celera Cytogenetic Map 1 q22 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Coronary Artery Disease, Autosomal Dominant 1 ISO RGD:1322126 8554872 ClinVar Annotator: match by term: Coronary artery disease/myocardial infarction ClinVar PMID:15496429 Coronary Artery Disease, Autosomal Dominant 1 ISO RGD:1322126 8554872 ClinVar Annotator: match by OMIM:608320 ClinVar PMID:14645853 , PMID:15841183
Imported Annotations - MGI
coronary artery disease ISS RGD:1322126 13592920 OMIM:300464 more ... MouseDO Imported Annotations - OMIM
Coronary Artery Disease, Autosomal Dominant 1 ISO RGD:1322126 7240710 OMIM
1,2-dichloroethane increases expression ISO RGD:1621608 6480464 ethylene dichloride results in increased expression of MEF2A mRNA CTD PMID:28960355 1,2-dimethylhydrazine multiple interactions EXP 6480464 [APC protein affects the susceptibility to 1, 2-Dimethylhydrazine] which results in increased expression of MEF2A mRNA CTD PMID:27840820 1,2-dimethylhydrazine decreases expression ISO RGD:1621608 6480464 1, 2-Dimethylhydrazine results in decreased expression of MEF2A mRNA CTD PMID:22206623 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of MEF2A mRNA CTD PMID:29097150 17beta-estradiol affects expression ISO RGD:1621608 6480464 Estradiol affects the expression of MEF2A mRNA CTD PMID:15598610 17beta-hydroxy-5alpha-androstan-3-one increases expression ISO RGD:1322126 6480464 Dihydrotestosterone results in increased expression of MEF2A mRNA CTD PMID:16631469 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1621608 6480464 Tetrachlorodibenzodioxin results in increased expression of MEF2A mRNA CTD PMID:24058054 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1322126 6480464 Tetrachlorodibenzodioxin results in increased expression of MEF2A mRNA CTD PMID:20106945 more ... 2-amino-2-deoxy-D-glucopyranose multiple interactions ISO RGD:1322126 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA] more ... CTD PMID:20165829 2-amino-2-deoxy-D-glucopyranose decreases expression EXP 6480464 Glucosamine results in decreased expression of MEF2A mRNA, Glucosamine results in decreased expression of MEF2A protein CTD PMID:20165829 2-amino-2-deoxy-D-glucopyranose decreases expression ISO RGD:1322126 6480464 Glucosamine results in decreased expression of MEF2A mRNA, Glucosamine results in decreased expression of MEF2A protein CTD PMID:20165829 2-amino-2-deoxy-D-glucopyranose multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA] more ... CTD PMID:20165829 3,4-methylenedioxymethamphetamine increases expression ISO RGD:1621608 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in increased expression of MEF2A mRNA CTD PMID:20188158 3,4-methylenedioxymethamphetamine decreases expression ISO RGD:1621608 6480464 N-Methyl-3, 4-methylenedioxyamphetamine results in decreased expression of MEF2A mRNA CTD PMID:26251327 4-phenylbutyric acid multiple interactions ISO RGD:1322126 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA], 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] CTD PMID:20165829 4-phenylbutyric acid multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA], 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] CTD PMID:20165829 5-azacytidine increases expression ISO RGD:1621608 6480464 Azacitidine results in increased expression of MEF2A CTD PMID:12094073 5-azacytidine affects expression ISO RGD:1621608 6480464 Azacitidine affects the expression of MEF2A protein CTD PMID:19002953 aflatoxin B1 increases methylation ISO RGD:1322126 6480464 Aflatoxin B1 results in increased methylation of MEF2A gene CTD PMID:28458013 aldehydo-D-glucosamine decreases expression EXP 6480464 Glucosamine results in decreased expression of MEF2A mRNA, Glucosamine results in decreased expression of MEF2A protein CTD PMID:20165829 aldehydo-D-glucosamine decreases expression ISO RGD:1322126 6480464 Glucosamine results in decreased expression of MEF2A mRNA, Glucosamine results in decreased expression of MEF2A protein CTD PMID:20165829 aldehydo-D-glucosamine multiple interactions ISO RGD:1322126 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA] more ... CTD PMID:20165829 aldehydo-D-glucosamine multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA] more ... CTD PMID:20165829 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1322126 6480464 7 more ... CTD PMID:19150397 , PMID:20018196 beta-D-glucosamine decreases expression EXP 6480464 Glucosamine results in decreased expression of MEF2A mRNA, Glucosamine results in decreased expression of MEF2A protein CTD PMID:20165829 beta-D-glucosamine multiple interactions EXP 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA] more ... CTD PMID:20165829 beta-D-glucosamine decreases expression ISO RGD:1322126 6480464 Glucosamine results in decreased expression of MEF2A mRNA, Glucosamine results in decreased expression of MEF2A protein CTD PMID:20165829 beta-D-glucosamine multiple interactions ISO RGD:1322126 6480464 4-phenylbutyric acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA] more ... CTD PMID:20165829 bis(2-chloroethyl) sulfide increases expression ISO RGD:1621608 6480464 Mustard Gas results in increased expression of MEF2A mRNA CTD PMID:15674843 , PMID:18955075 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of MEF2A mRNA CTD PMID:29097150 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of MEF2A mRNA CTD PMID:30816183 bisphenol A increases expression ISO RGD:1322126 6480464 bisphenol A results in increased expression of MEF2A mRNA CTD PMID:29275510 cadmium dichloride increases expression ISO RGD:1322126 6480464 Cadmium Chloride results in increased expression of MEF2A mRNA CTD PMID:26472689 caffeine multiple interactions EXP 6480464 Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA], Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein] CTD PMID:25093688 caffeine increases expression EXP 6480464 Caffeine results in increased expression of MEF2A mRNA, Caffeine results in increased expression of MEF2A protein CTD PMID:25093688 carbamazepine affects expression ISO RGD:1322126 6480464 Carbamazepine affects the expression of MEF2A mRNA CTD PMID:24752500 chloroprene increases expression EXP 6480464 Chloroprene results in increased expression of MEF2A mRNA CTD PMID:23125180 choline multiple interactions ISO RGD:1621608 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MEF2A gene CTD PMID:20938992 cocaine increases expression EXP 6480464 Cocaine results in increased expression of MEF2A mRNA CTD PMID:17898221 coumestrol multiple interactions ISO RGD:1322126 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MEF2A mRNA CTD PMID:19167446 coumestrol decreases expression ISO RGD:1322126 6480464 Coumestrol results in decreased expression of MEF2A mRNA CTD PMID:19167446 cyclosporin A increases expression ISO RGD:1322126 6480464 Cyclosporine results in increased expression of MEF2A mRNA CTD PMID:20106945 cyclosporin A decreases methylation ISO RGD:1322126 6480464 Cyclosporine results in decreased methylation of MEF2A promoter CTD PMID:27989131 dantrolene multiple interactions EXP 6480464 Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA], Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein] CTD PMID:25093688 dibutyl phthalate increases expression EXP 6480464 Dibutyl Phthalate results in increased expression of MEF2A mRNA CTD PMID:21266533 diclofenac affects expression ISO RGD:1322126 6480464 Diclofenac affects the expression of MEF2A mRNA CTD PMID:24752500 dioxygen increases expression ISO RGD:1322126 6480464 Oxygen deficiency results in increased expression of MEF2A mRNA CTD PMID:26516004 dorsomorphin multiple interactions ISO RGD:1322126 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases expression ISO RGD:1322126 6480464 Doxorubicin results in increased expression of MEF2A mRNA CTD PMID:16001973 endosulfan decreases expression EXP 6480464 Endosulfan results in decreased expression of MEF2A mRNA CTD PMID:31464424 enniatin decreases expression EXP 6480464 enniatins results in decreased expression of MEF2A mRNA CTD PMID:27163883 Enterolactone multiple interactions ISO RGD:1322126 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of MEF2A mRNA CTD PMID:19167446 ethanol affects splicing ISO RGD:1621608 6480464 Ethanol affects the splicing of MEF2A mRNA CTD PMID:30319688 folic acid multiple interactions ISO RGD:1621608 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MEF2A gene CTD PMID:20938992 folic acid decreases expression ISO RGD:1621608 6480464 Folic Acid deficiency results in decreased expression of MEF2A, Folic Acid results in decreased expression of MEF2A mRNA CTD PMID:25384423 , PMID:25629700 geraniol increases expression ISO RGD:1322126 6480464 geraniol results in increased expression of MEF2A mRNA CTD PMID:27683099 L-methionine multiple interactions ISO RGD:1621608 6480464 [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of MEF2A gene CTD PMID:20938992 lead diacetate affects expression ISO RGD:1621608 6480464 lead acetate affects the expression of MEF2A mRNA CTD PMID:21829687 leflunomide increases expression ISO RGD:1322126 6480464 leflunomide results in increased expression of MEF2A mRNA CTD PMID:28988120 metformin increases expression ISO RGD:1322126 6480464 Metformin results in increased expression of MEF2A mRNA CTD PMID:15864539 methylmercury chloride increases expression ISO RGD:1621608 6480464 methylmercuric chloride results in increased expression of MEF2A mRNA CTD PMID:29104120 methylmercury chloride decreases expression ISO RGD:1322126 6480464 methylmercuric chloride results in decreased expression of MEF2A mRNA CTD PMID:28001369 metoprolol multiple interactions EXP 6480464 Metoprolol inhibits the reaction [[[PPARGC1A protein results in increased expression of MEF2A mRNA] co-treated with [PPARGC1A protein results in increased expression of PPARA mRNA]] results in increased expression of CPT1B protein], Metoprolol inhibits the reaction [MEF2A protein binds to CPT1B promoter] CTD PMID:19233164 nickel atom affects expression ISO RGD:1322126 6480464 Nickel affects the expression of MEF2A mRNA CTD PMID:14575637 nickel atom multiple interactions ISO RGD:1322126 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of MEF2A mRNA] CTD PMID:14575637 nitric oxide decreases expression ISO RGD:1621608 6480464 Nitric Oxide deficiency results in decreased expression of MEF2A mRNA CTD PMID:15878706 oxytocin multiple interactions ISO RGD:1322126 6480464 MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 mRNA], MEF2A protein promotes the reaction [Oxytocin results in increased expression of KLF4 protein] CTD PMID:29104011 paracetamol increases expression ISO RGD:1322126 6480464 Acetaminophen results in increased expression of MEF2A mRNA CTD PMID:26690555 , PMID:29067470 phenobarbital affects expression ISO RGD:1621608 6480464 Phenobarbital affects the expression of MEF2A mRNA CTD PMID:23091169 phenylmercury acetate decreases expression ISO RGD:1322126 6480464 Phenylmercuric Acetate results in decreased expression of MEF2A mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1322126 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEF2A mRNA CTD PMID:27188386 propiconazole decreases expression ISO RGD:1621608 6480464 propiconazole results in decreased expression of MEF2A mRNA CTD PMID:21278054 raloxifene multiple interactions ISO RGD:1322126 6480464 [Raloxifene Hydrochloride co-treated with ESR2 protein] results in decreased expression of MEF2A mRNA CTD PMID:19059307 S-butyl-DL-homocysteine (S,R)-sulfoximine increases expression ISO RGD:1621608 6480464 Buthionine Sulfoximine results in increased expression of MEF2A mRNA CTD PMID:15878706 SB 431542 multiple interactions ISO RGD:1322126 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenate increases expression ISO RGD:1621608 6480464 sodium arsenate results in increased expression of MEF2A mRNA CTD PMID:21795629 , PMID:30953684 sodium arsenite increases expression EXP 6480464 sodium arsenite results in increased expression of MEF2A mRNA, sodium arsenite results in increased expression of MEF2A protein CTD PMID:25089838 succimer multiple interactions ISO RGD:1621608 6480464 [Succimer binds to Magnetite Nanoparticles] which results in decreased expression of MEF2A mRNA CTD PMID:21641980 sulfates multiple interactions ISO RGD:1322126 6480464 [Soot co-treated with Sulfates] affects the methylation of MEF2A promoter CTD PMID:25395096 tamoxifen multiple interactions ISO RGD:1322126 6480464 [Tamoxifen co-treated with ESR2 protein] results in decreased expression of MEF2A mRNA CTD PMID:19059307 tauroursodeoxycholic acid multiple interactions ISO RGD:1322126 6480464 tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA], tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] CTD PMID:20165829 tauroursodeoxycholic acid multiple interactions EXP 6480464 tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A mRNA], tauroursodeoxycholic acid inhibits the reaction [Glucosamine results in decreased expression of MEF2A protein] CTD PMID:20165829 theophylline decreases expression ISO RGD:1322126 6480464 Theophylline results in decreased expression of MEF2A mRNA CTD PMID:18951874 topotecan decreases expression EXP 6480464 Topotecan results in decreased expression of MEF2A mRNA CTD PMID:25729387 torcetrapib increases expression ISO RGD:1322126 6480464 torcetrapib results in increased expression of MEF2A mRNA CTD PMID:23228038 trichostatin A multiple interactions ISO RGD:1322126 6480464 trichostatin A inhibits the reaction [Nickel affects the expression of MEF2A mRNA] CTD PMID:14575637 urethane increases expression ISO RGD:1322126 6480464 Urethane results in increased expression of MEF2A mRNA CTD PMID:28818685 valproic acid decreases methylation ISO RGD:1322126 6480464 Valproic Acid results in decreased methylation of MEF2A gene CTD PMID:29154799 valproic acid increases methylation ISO RGD:1322126 6480464 Valproic Acid results in increased methylation of MEF2A gene CTD PMID:28853863 , PMID:29201983 valproic acid multiple interactions ISO RGD:1322126 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MEF2A mRNA CTD PMID:27188386 valproic acid decreases expression ISO RGD:1322126 6480464 Valproic Acid results in decreased expression of MEF2A mRNA CTD PMID:23179753 more ... vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of MEF2A mRNA CTD PMID:19015723 vorinostat decreases expression ISO RGD:1322126 6480464 vorinostat results in decreased expression of MEF2A mRNA CTD PMID:27188386 zinc atom multiple interactions ISO RGD:1322126 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of MEF2A mRNA CTD PMID:18593933 zinc(0) multiple interactions ISO RGD:1322126 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of MEF2A mRNA CTD PMID:18593933
Biological Process apoptotic process IEA UniProtKB-KW:KW-0053 1600115 GO_REF:0000043 UniProt GO_REF:0000043 cardiac conduction IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 cardiac conduction ISO RGD:1621608 1624291 (MGI:2429350, PMID:12379849) RGD MGI:2429350 , PMID:12379849 cell differentiation IBA FB:FBgn0011656 more ... 13792537 PMID:21873635 GO_Central cellular response to calcium ion ISO RGD:1322126 1624291 (PMID:16484498) RGD PMID:16484498 cellular response to calcium ion IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to calcium ion IDA 8553671 PMID:10521511 UniProt cellular response to glucose stimulus IEP 2312263 RGD dendrite morphogenesis IMP 8553655 PMID:16484498 UniProt ERK5 cascade ISO RGD:1322126 1624291 (PMID:15132737) RGD PMID:15132737 ERK5 cascade ISS UniProtKB:Q02078 1600115 GO_REF:0000024 UniProt GO_REF:0000024 ERK5 cascade IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 heart development ISO RGD:1322126 1624291 (PMID:10458488) RGD PMID:10458488 heart development IBA PANTHER:PTN002632019 more ... 13792537 PMID:21873635 GO_Central MAPK cascade ISO RGD:1322126 1624291 (PMID:9858528) RGD PMID:9858528 MAPK cascade ISS UniProtKB:Q02078 1600115 GO_REF:0000024 UniProt GO_REF:0000024 mitochondrial genome maintenance IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitochondrial genome maintenance ISO RGD:1621608 1624291 (MGI:2429350, PMID:12379849) RGD MGI:2429350 , PMID:12379849 mitochondrion distribution IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 mitochondrion distribution ISO RGD:1621608 1624291 (MGI:2429350, PMID:12379849) RGD MGI:2429350 , PMID:12379849 negative regulation of transcription by RNA polymerase II ISO RGD:1322126 1624291 (PMID:16484498) RGD PMID:16484498 negative regulation of transcription by RNA polymerase II ISS UniProtKB:Q02078 1600115 GO_REF:0000024 UniProt GO_REF:0000024 negative regulation of transcription by RNA polymerase II IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 nervous system development IEA UniProtKB-KW:KW-0524 1600115 GO_REF:0000043 UniProt GO_REF:0000043 positive regulation of cardiac muscle hypertrophy IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cardiac muscle hypertrophy ISO RGD:1322126 1624291 UniProtKB:P61296 (PMID:24161931) RGD PMID:24161931 positive regulation of gene expression ISO RGD:1621608 1624291 (MGI:6159438, PMID:29606596) RGD MGI:6159438 , PMID:29606596 positive regulation of glucose import IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of glucose import ISO RGD:1621608 1624291 (MGI:3054887, PMID:12097321) RGD MGI:3054887 , PMID:12097321 positive regulation of transcription by RNA polymerase II IDA 8553671 PMID:10521511 UniProt positive regulation of transcription by RNA polymerase II ISO RGD:1621608 1624291 MGI:96919 more ... RGD MGI:3639834 more ... positive regulation of transcription by RNA polymerase II IBA FB:FBgn0011656 more ... 13792537 PMID:21873635 GO_Central positive regulation of transcription by RNA polymerase II IMP 13210532 PMID:26240138 BHF-UCL positive regulation of transcription by RNA polymerase II IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II IEA InterPro:IPR033896 1600115 GO_REF:0000002 InterPro GO_REF:0000002 positive regulation of transcription by RNA polymerase II ISO RGD:1322126 1624291 (PMID:10748098), (PMID:15466416), (PMID:20590529), (PMID:21468593), (PMID:7760790), (PMID:9858528) RGD PMID:10748098 more ... positive regulation of transcription, DNA-templated IMP 8553739 PMID:17696759 UniProt positive regulation of transcription, DNA-templated ISO RGD:1621608 1624291 (MGI:3054887, PMID:12097321) RGD MGI:3054887 , PMID:12097321 regulation of transcription, DNA-templated ISO RGD:1621608 1624291 (MGI:1289810 more ... RGD MGI:1289810 more ... transcription, DNA-templated ISO RGD:1322126 1624291 (PMID:16043483) RGD PMID:16043483 transcription, DNA-templated IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 ventricular cardiac myofibril assembly IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 ventricular cardiac myofibril assembly ISO RGD:1621608 1624291 (MGI:2429350, PMID:12379849) RGD MGI:2429350 , PMID:12379849 Cellular Component chromatin IBA MGI:MGI:99532 , PANTHER:PTN000235434 13792537 PMID:21873635 GO_Central chromatin ISO RGD:1621608 1624291 (MGI:4838688, PMID:20833138) RGD MGI:4838688 , PMID:20833138 chromatin IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:1322126 1624291 RGD GO_REF:0000052 nucleoplasm ISO RGD:1322126 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm TAS 1600115 Reactome:R-RNO-199913 Reactome Reactome:R-RNO-199913 nucleus IDA 8553739 PMID:17696759 UniProt nucleus ISO RGD:1621608 1624291 (MGI:3522543 more ... RGD MGI:3522543 more ... nucleus IBA FB:FBgn0011656 more ... 13792537 PMID:21873635 GO_Central nucleus IEA UniProtKB-SubCell:SL-0191 1600115 GO_REF:0000044 UniProt GO_REF:0000044 nucleus ISS UniProtKB:Q02078 1600115 GO_REF:0000024 UniProt GO_REF:0000024 nucleus ISO RGD:1322126 1624291 (PMID:16484498), (PMID:20590529) RGD PMID:16484498 , PMID:20590529 transcription regulator complex ISO RGD:1322126 1624291 (PMID:16043483) RGD PMID:16043483 transcription regulator complex IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 Molecular Function activating transcription factor binding ISO RGD:1322126 1624291 UniProtKB:Q14814 (PMID:20590529) RGD PMID:20590529 activating transcription factor binding ISO RGD:1621608 1624291 UniProtKB:Q62432 (MGI:5009194 , PMID:11160896) RGD MGI:5009194 , PMID:11160896 activating transcription factor binding ISS UniProtKB:Q02078 1600115 GO_REF:0000024 UniProt GO_REF:0000024 activating transcription factor binding IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 activating transcription factor binding IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromatin binding ISO RGD:1322126 1624291 (PMID:21468593) RGD PMID:21468593 chromatin binding ISO RGD:1621608 1624291 (MGI:3639834 more ... RGD MGI:3639834 more ... chromatin binding ISS UniProtKB:Q02078 1600115 GO_REF:0000024 UniProt GO_REF:0000024 chromatin binding IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 chromatin binding IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA binding ISO RGD:1621608 1624291 (MGI:1289810 more ... RGD MGI:1289810 more ... DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:1322126 1624291 (PMID:15466416), (PMID:7760790) RGD PMID:15466416 , PMID:7760790 DNA-binding transcription activator activity, RNA polymerase II-specific ISO RGD:1621608 1624291 (MGI:3639834, PMID:16407236) RGD MGI:3639834 , PMID:16407236 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription activator activity, RNA polymerase II-specific IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 DNA-binding transcription factor activity ISO RGD:1322126 1624291 (PMID:16043483) RGD PMID:16043483 DNA-binding transcription factor activity ISO RGD:1621608 1624291 (MGI:1289810 more ... RGD MGI:1289810 more ... DNA-binding transcription factor activity, RNA polymerase II-specific IDA 8553671 PMID:10521511 UniProt DNA-binding transcription factor activity, RNA polymerase II-specific ISO RGD:1621608 1624291 (MGI:4950833, PMID:21379568) RGD MGI:4950833 , PMID:21379568 DNA-binding transcription factor activity, RNA polymerase II-specific IBA FB:FBgn0011656 more ... 13792537 PMID:21873635 GO_Central DNA-binding transcription factor activity, RNA polymerase II-specific ISO RGD:1322126 1624291 (PMID:10748098), (PMID:16484498), (PMID:20590529) RGD PMID:10748098 more ... histone acetyltransferase binding ISO RGD:1322126 1624291 UniProtKB:Q09472 (PMID:20590529) RGD PMID:20590529 histone acetyltransferase binding ISS UniProtKB:Q02078 1600115 GO_REF:0000024 UniProt GO_REF:0000024 histone acetyltransferase binding IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 histone deacetylase binding ISO RGD:1322126 1624291 UniProtKB:Q13547 more ... RGD PMID:10748098 , PMID:20590529 histone deacetylase binding IBA MGI:MGI:99458 more ... 13792537 PMID:21873635 GO_Central histone deacetylase binding ISS UniProtKB:Q02078 1600115 GO_REF:0000024 UniProt GO_REF:0000024 histone deacetylase binding IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein binding contributes_to ISO RGD:1322126 1624291 UniProtKB:Q92793 (PMID:16043483) RGD PMID:16043483 protein binding ISO RGD:1621608 1624291 PR:Q9EPW2 more ... RGD MGI:3054887 more ... protein binding ISO RGD:1322126 1624291 UniProtKB:O75031 more ... RGD PMID:15466416 more ... protein dimerization activity IEA InterPro:IPR002100 , InterPro:IPR036879 1600115 GO_REF:0000002 InterPro GO_REF:0000002 protein heterodimerization activity ISO RGD:1322126 1624291 UniProtKB:Q63943 (PMID:9858528) RGD PMID:9858528 protein heterodimerization activity IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein kinase binding IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 protein kinase binding ISO RGD:1621608 1624291 UniProtKB:O54949 (MGI:3843420 , PMID:17785444) RGD MGI:3843420 , PMID:17785444 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1322126 1624291 (PMID:7760790) RGD PMID:7760790 RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO RGD:1621608 1624291 (MGI:5319024 more ... RGD MGI:5319024 more ... RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA MGI:MGI:99458 more ... 13792537 PMID:21873635 GO_Central RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA UniProtKB:Q60929 , ensembl:ENSMUSP000001174961600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase II transcription factor binding ISO RGD:1322126 1624291 UniProtKB:Q99697-3 (PMID:15466416) RGD PMID:15466416 RNA polymerase II transcription factor binding IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO RGD:1322126 1624291 (PMID:20590529) RGD PMID:20590529 RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA MGI:MGI:104526 more ... 13792537 PMID:21873635 GO_Central RNA polymerase II transcription regulatory region sequence-specific DNA binding ISS UniProtKB:Q02078 1600115 GO_REF:0000024 UniProt GO_REF:0000024 RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA InterPro:IPR033896 1600115 GO_REF:0000002 InterPro GO_REF:0000002 sequence-specific DNA binding ISO RGD:1322126 1624291 (PMID:10835359) RGD PMID:10835359 sequence-specific DNA binding ISO RGD:1621608 1624291 (MGI:52878, PMID:8096811) RGD MGI:52878 , PMID:8096811 sequence-specific DNA binding IBA MGI:MGI:99458 more ... 13792537 PMID:21873635 GO_Central sequence-specific DNA binding IDA 8553671 PMID:10521511 UniProt SMAD binding ISO RGD:1322126 1624291 UniProtKB:Q15796 (PMID:11160896) RGD PMID:11160896 SMAD binding ISS UniProtKB:Q02078 1600115 GO_REF:0000024 UniProt GO_REF:0000024 SMAD binding IEA UniProtKB:Q02078 , ensembl:ENSP000004530951600115 GO_REF:0000107 Ensembl GO_REF:0000107 transcription factor binding IBA PANTHER:PTN000235373 more ... 13792537 PMID:21873635 GO_Central transcription regulatory region sequence-specific DNA binding IBA FB:FBgn0011656 more ... 13792537 PMID:21873635 GO_Central
Gene-Chemical Interaction Annotations
