Ccr2 (C-C motif chemokine receptor 2) - Rat Genome Database

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Gene: Ccr2 (C-C motif chemokine receptor 2) Rattus norvegicus
Symbol: Ccr2
Name: C-C motif chemokine receptor 2
RGD ID: 620876
Description: ENCODES a protein that exhibits identical protein binding; C-C chemokine receptor activity (ortholog); CCR2 chemokine receptor binding (ortholog); INVOLVED IN blood vessel remodeling; cellular calcium ion homeostasis; chemokine-mediated signaling pathway; PARTICIPATES IN chemokine mediated signaling pathway; cytokine mediated signaling pathway; ASSOCIATED WITH demyelinating disease; Experimental Arthritis; Experimental Autoimmune Encephalomyelitis; FOUND IN cytosol; dendrite; neuronal cell body; INTERACTS WITH (+)-pilocarpine; 17alpha-ethynylestradiol; acrylamide
Type: protein-coding
Also known as: C-C chemokine receptor type 2; C-C CKR-2; CC-CKR-2; CCR-2; chemokine (C-C motif) receptor 2; chemokine receptor CCR2; chemokine receptor CCR2 gene
RGD Orthologs
Green Monkey
Alliance Genes
More Info more info ...
Allele / Splice: Ccr2m1Mcwi   Ccr2m2Mcwi  
Genetic Models: FHH-Ccr2m1Mcwi BN-Ccr2m2Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.28123,734,465 - 123,742,483 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl8123,734,430 - 123,742,100 (+)Ensembl
RGSC_v3.48128,892,784 - 128,893,905 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,912,520 - 128,913,642 (+)NCBI
Celera8122,833,545 - 122,834,666 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
age related macular degeneration  (ISS)
aggressive periodontitis  (ISO)
Alcoholic Fatty Liver  (ISO)
allergic bronchopulmonary aspergillosis  (ISO)
allergic contact dermatitis  (ISO)
allergic disease  (ISO)
Alveolar Bone Loss  (ISO)
amyotrophic lateral sclerosis  (ISO)
Animal Toxoplasmosis  (ISO)
anxiety disorder  (ISO)
asthma  (ISO)
atopic dermatitis  (ISO)
bacterial pneumonia  (ISO)
Bronchial Hyperreactivity  (ISO)
bronchiolitis obliterans  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Choroidal Neovascularization  (ISO)
Chronic Periodontitis  (ISO)
congestive heart failure  (ISO)
corneal neovascularization  (ISO)
coronary artery disease  (ISO)
Coronavirus infectious disease  (ISS)
cutaneous leishmaniasis  (ISO)
demyelinating disease  (IEP)
dermatomyositis  (ISO)
Diabetic Nephropathies  (ISO)
dry eye syndrome  (ISO)
Experimental Arthritis  (IEP)
Experimental Autoimmune Encephalomyelitis  (IEP)
Experimental Autoimmune Uveitis  (ISO)
Experimental Autoimmune Uveoretinitis  (ISO)
fungal infectious disease  (ISO)
Geographic Atrophy  (ISO)
Hearing Loss, Noise-Induced  (ISO)
Herpes Simplex Encephalitis  (ISO)
Herpesviridae Infections  (ISO)
human immunodeficiency virus infectious disease  (ISO)
Hyperalgesia  (IEP,IMP,ISO)
Hypoxia-Ischemia, Brain  (IEP)
ileitis  (ISO)
inclusion body myositis  (ISO)
intermediate uveitis  (ISO)
interstitial lung disease  (ISO)
Intervertebral Disc Disease  (IEP)
Intimal Hyperplasia  (ISO)
Kawasaki disease  (ISO)
Knee Osteoarthritis  (ISO)
Kuhnt-Junius degeneration  (ISO)
leishmaniasis  (ISO)
limited scleroderma  (ISO)
lipoatrophic diabetes mellitus  (ISO)
liver disease  (ISO)
Liver Reperfusion Injury  (ISO)
lung disease  (ISO)
macular degeneration  (ISO)
Mouth Neoplasms  (ISO)
myeloid sarcoma  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (ISO)
Nasal Polyps  (ISO)
non-alcoholic fatty liver disease  (ISO)
oral squamous cell carcinoma  (ISO)
Pain  (IMP,ISO)
Perennial Allergic Rhinitis  (ISO)
Peri-Implantitis  (ISO)
Periapical Diseases  (ISO)
periapical granuloma  (ISO)
periapical periodontitis  (IEP)
Periodontal Cyst  (ISO)
pleural tuberculosis  (ISO)
pneumonia  (ISO)
polymyositis  (ISO)
posterior uveitis  (ISO)
prediabetes syndrome  (ISO)
psoriasis  (ISO)
psoriatic arthritis  (ISO)
pulmonary fibrosis  (ISO)
pulmonary tuberculosis  (ISO)
retinal degeneration  (ISO)
retinitis  (ISO)
rhinitis  (ISO)
sarcoidosis  (ISO)
sciatic neuropathy  (ISO)
sialadenitis  (ISO)
Spinal Cord Injuries  (IEP)
status epilepticus  (ISO)
systemic scleroderma  (ISO)
Thoracic Injuries  (IEP)
Transplant Rejection  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)
urticaria  (ISO)
vasculitis  (ISO)
visceral leishmaniasis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (EXP,ISO)
(R)-mevalonic acid  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-phenylenediamine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-O-palmitoyl-2-O-(5-oxovaleryl)-sn-glycero-3-phosphocholine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2-acetyl-1-alkyl-sn-glycero-3-phosphocholine  (ISO)
2-butoxyethanol  (ISO)
3-chlorophenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
9-cis-retinoic acid  (ISO)
acetaldehyde  (ISO)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amphetamine  (EXP)
amphotericin B  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
asbestos  (ISO)
asperentin  (ISO)
barium sulfate  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
benzylpenicillin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP)
bleomycin A2  (ISO)
buta-1,3-diene  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
ceric oxide  (EXP)
chenodeoxycholic acid  (ISO)
chloroprene  (ISO)
choline  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (ISO)
cocaine  (EXP,ISO)
crocidolite asbestos  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dibenz[a,h]anthracene  (EXP)
dibenzo[a,l]pyrene  (EXP)
diethylstilbestrol  (ISO)
disulfiram  (ISO)
doxorubicin  (EXP)
erythromycin A  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
eugenol  (ISO)
flumequine  (ISO)
folic acid  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
isoniazide  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
linuron  (ISO)
losartan  (EXP)
LY294002  (ISO)
mechlorethamine  (EXP)
MeIQx  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nefazodone  (ISO)
neoechinulin A  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
olaparib  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paricalcitol  (ISO)
PCB138  (ISO)
perindopril  (ISO)
picrotoxin  (EXP)
piperidines  (ISO)
proanthocyanidin  (ISO)
protein kinase inhibitor  (ISO)
resveratrol  (ISO)
rotenone  (ISO)
SB 203580  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (EXP,ISO)
simvastatin  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium chlorate  (ISO)
sodium fluoride  (EXP)
sterigmatocystin  (ISO)
streptozocin  (ISO)
sulforaphane  (ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
telmisartan  (EXP)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
trans-caffeic acid  (ISO)
trichostatin A  (ISO)
tungsten  (ISO)
valproic acid  (EXP)
vinclozolin  (EXP)
zinc sulfate  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
blood vessel remodeling  (IEP)
calcium-mediated signaling  (IBA)
cell chemotaxis  (IBA)
cellular calcium ion homeostasis  (IDA)
cellular defense response  (ISO)
cellular homeostasis  (ISO,ISS)
chemokine-mediated signaling pathway  (IMP)
cytokine-mediated signaling pathway  (IMP,ISO)
G protein-coupled receptor signaling pathway  (IMP)
hemopoiesis  (ISO)
homeostasis of number of cells within a tissue  (ISO)
humoral immune response  (ISO)
immune response  (IBA,ISO)
inflammatory response  (IBA,IDA,ISO)
inflammatory response to antigenic stimulus  (IEP)
inflammatory response to wounding  (ISO,ISS)
leukocyte adhesion to vascular endothelial cell  (ISO)
macrophage migration  (ISO,ISS)
monocyte chemotaxis  (ISO)
monocyte extravasation  (ISO,ISS)
negative regulation of angiogenesis  (ISO,ISS)
negative regulation of eosinophil degranulation  (ISO,ISS)
negative regulation of type 2 immune response  (ISO,ISS)
neutrophil clearance  (ISO)
positive regulation of alpha-beta T cell proliferation  (ISO,ISS)
positive regulation of astrocyte chemotaxis  (ISO,ISS)
positive regulation of CD8-positive, alpha-beta T cell extravasation  (ISO,ISS)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of cytosolic calcium ion concentration  (IBA)
positive regulation of hematopoietic stem cell migration  (ISO,ISS)
positive regulation of immune complex clearance by monocytes and macrophages  (ISO,ISS)
positive regulation of inflammatory response  (ISO,ISS)
positive regulation of interferon-gamma production  (ISO,ISS)
positive regulation of interleukin-2 production  (ISO,ISS)
positive regulation of leukocyte tethering or rolling  (ISO)
positive regulation of monocyte chemotaxis  (ISO,ISS)
positive regulation of monocyte extravasation  (ISO,ISS)
positive regulation of NMDA glutamate receptor activity  (IGI)
positive regulation of p38MAPK cascade  (IDA)
positive regulation of synaptic transmission, glutamatergic  (ISO,ISS)
positive regulation of T cell activation  (ISO,ISS)
positive regulation of T cell chemotaxis  (ISO,ISS)
positive regulation of T-helper 1 type immune response  (ISO,ISS)
positive regulation of thymocyte migration  (ISO,ISS)
positive regulation of tumor necrosis factor production  (IMP,ISO,ISS)
regulation of cell migration  (ISO)
regulation of inflammatory response  (ISO,ISS)
regulation of T cell cytokine production  (ISO,ISS)
regulation of T cell differentiation  (ISO,ISS)
regulation of vascular endothelial growth factor production  (ISO,ISS)
response to hyperoxia  (IEP)
response to hypoxia  (IEP)
sensory perception of pain  (ISO,ISS)
T-helper 17 cell chemotaxis  (ISO,ISS)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View

References - curated
1. Ahad MA, etal., Mol Vis. 2007 Mar 23;13:388-96.
2. Ambati BK, etal., Cornea. 2003 Jul;22(5):465-7.
3. An JL, etal., Forensic Sci Int. 2009 Nov 20;192(1-3):e21-5. Epub 2009 Sep 4.
4. Arai M, etal., J Dermatol Sci. 2013 Mar;69(3):250-8. doi: 10.1016/j.jdermsci.2012.10.010. Epub 2012 Oct 24.
5. Ayers CM, etal., Int Forum Allergy Rhinol. 2011 Jul-Aug;1(4):296-302. doi: 10.1002/alr.20046. Epub 2011 Apr 11.
6. Banisadr G, etal., J Comp Neurol. 2005 Nov 14;492(2):178-92.
7. Barros SP, etal., J Periodontal Res. 2011 Apr;46(2):246-51. doi: 10.1111/j.1600-0765.2010.01340.x. Epub 2011 Jan 18.
8. Bektas-Kayhan K, etal., Oral Dis. 2012 Jan;18(1):55-9. doi: 10.1111/j.1601-0825.2011.01843.x. Epub 2011 Aug 24.
9. Belperio JA, etal., J Clin Invest. 2001 Aug;108(4):547-56.
10. Bhangoo S, etal., Mol Pain. 2007 Dec 12;3:38.
11. Blease K, etal., J Immunol. 2000 Sep 1;165(5):2603-11.
12. Boivin N, etal., J Gen Virol. 2012 Jun;93(Pt 6):1294-304. doi: 10.1099/vir.0.041046-0. Epub 2012 Feb 29.
13. Breunis WB, etal., Clin Exp Immunol. 2007 Oct;150(1):83-90. Epub 2007 Aug 2.
14. Brzoza Z, etal., Allergol Immunopathol (Madr). 2013 May 30. pii: S0301-0546(13)00103-1. doi: 10.1016/j.aller.2013.02.003.
15. Campbell EM, etal., J Immunol. 1999 Aug 15;163(4):2160-7.
16. Chen MK, etal., Oral Oncol. 2011 Jul;47(7):577-82. doi: 10.1016/j.oraloncology.2011.04.008. Epub 2011 May 12.
17. Chen YF, etal., Am J Pathol. 2014 Jun;184(6):1695-705. doi: 10.1016/j.ajpath.2014.02.024. Epub 2014 Apr 13.
18. Cho J and Gruol DL, J Neuroimmunol. 2008 Aug 13;199(1-2):94-103. Epub 2008 Jun 27.
19. Craven M, etal., PLoS One. 2012;7(7):e41594. doi: 10.1371/journal.pone.0041594. Epub 2012 Jul 25.
20. Dagkalis A, etal., Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4288-94. doi: 10.1167/iovs.09-3434. Epub 2009 Apr 8.
21. Dansereau MA, etal., J Neurochem. 2008 Jul;106(2):757-69. Epub 2008 Apr 17.
22. De Paepe B and De Bleecker JL, Muscle Nerve. 2005 May;31(5):621-7.
23. Despriet DD, etal., Invest Ophthalmol Vis Sci. 2008 Jan;49(1):364-71. doi: 10.1167/iovs.07-0656.
24. Dhaouadi T, etal., Iran J Allergy Asthma Immunol. 2013 Mar;12(1):29-36. doi: 012.01/ijaai.2936.
25. Dong N, etal., Mol Vis. 2014 May 2;20:616-28. eCollection 2014.
26. Egan CE, etal., Mucosal Immunol. 2009 Nov;2(6):527-35. doi: 10.1038/mi.2009.105. Epub 2009 Sep 9.
27. Faaij CM, etal., Pediatr Blood Cancer. 2010 Aug;55(2):344-8. doi: 10.1002/pbc.22500.
28. Feng X and Yao YJ, Sichuan Da Xue Xue Bao Yi Xue Ban. 2007 Nov;38(6):942-4, 964.
29. Gambelunghe G, etal., Hum Immunol. 2003 Jun;64(6):629-32.
30. Garlet TP, etal., J Endod. 2010 Feb;36(2):244-50. doi: 10.1016/j.joen.2009.09.004. Epub 2009 Oct 23.
31. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
32. Goodyear A, etal., J Immunol. 2010 Feb 1;184(3):1445-54. Epub 2009 Dec 30.
33. Goyal S, etal., Arch Ophthalmol. 2009 Jul;127(7):882-7. doi: 10.1001/archophthalmol.2009.125.
34. Grunin M, etal., Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5292-300. doi: 10.1167/iovs.11-9165.
35. Guazzone VA, etal., J Reprod Immunol 2003 Dec;60(2):143-57.
36. Guo C, etal., Exp Eye Res. 2012 Nov;104:39-47. doi: 10.1016/j.exer.2012.08.013. Epub 2012 Sep 26.
37. Haas CS, etal., Arthritis Rheum. 2005 Dec;52(12):3718-30.
38. Hartl D, etal., Respir Res. 2005 Aug 11;6:93.
39. Hasegawa H, etal., Arthritis Res Ther. 2007;9(1):R15.
40. Hildebrandt GC, etal., Blood. 2004 Mar 15;103(6):2417-26. Epub 2003 Nov 13.
41. Hu JH, etal., Brain Res. 2013 May 6;1509:1-7. doi: 10.1016/j.brainres.2013.03.002. Epub 2013 Mar 17.
42. Ibrahim MK, etal., Infect Immun. 2014 May 12.
43. Jerath MR, etal., Thromb J. 2010 Sep 13;8:14. doi: 10.1186/1477-9560-8-14.
44. Ji J, etal., Infect Immun. 2003 Aug;71(8):4278-88.
45. Ji JF, etal., Neurosci Lett. 2004 Jan 30;355(3):236-40.
46. Jiang Y, etal., J Neuroimmunol 1998 Jun 1;86(1):1-12.
47. Kanamori H, etal., Biochem Biophys Res Commun. 2007 Sep 7;360(4):772-7. Epub 2007 Jul 6.
48. Keino H, etal., Graefes Arch Clin Exp Ophthalmol. 2003 Feb;241(2):111-5. Epub 2003 Jan 28.
49. Kim YK, etal., Allergy. 2007 Feb;62(2):208-9.
50. Knerlich-Lukoschus F, etal., J Neurotrauma. 2008 May;25(5):427-48.
51. Lam SY, etal., Histochem Cell Biol. 2008 Sep;130(3):549-59. Epub 2008 May 1.
52. Lee I, etal., J Immunol. 2003 Dec 15;171(12):6929-35.
53. Liu L, etal., Arch Oral Biol. 2014 May;59(5):492-9. doi: 10.1016/j.archoralbio.2014.02.008. Epub 2014 Feb 22.
54. Lu P, etal., Cornea. 2009 Jun;28(5):562-9. doi: 10.1097/ICO.0b013e3181930bcd.
55. Martinez HG, etal., BMC Immunol. 2012 Oct 17;13:56. doi: 10.1186/1471-2172-13-56.
56. McMillan TR, etal., Am J Respir Crit Care Med. 2008 Apr 1;177(7):771-80. Epub 2008 Jan 10.
57. MGD data from the GO Consortium
58. Miller RE, etal., Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20602-7. doi: 10.1073/pnas.1209294110. Epub 2012 Nov 26.
59. Mine S, etal., Biochem Biophys Res Commun. 2006 Jun 9;344(3):780-5. Epub 2006 Apr 17.
60. Moore BB, etal., Am J Pathol. 2005 Mar;166(3):675-84.
61. Na TY, etal., J Pathol. 2015 Apr;235(5):710-20. doi: 10.1002/path.4494. Epub 2015 Jan 5.
62. Nakajima K, etal., Diabetes. 2002 Jan;51(1):238-42.
63. Nakamura H, etal., Int Arch Allergy Immunol. 2007;142(4):329-34. Epub 2006 Nov 28.
64. NCBI rat LocusLink and RefSeq merged data July 26, 2002
65. Okuma T, etal., Int J Exp Pathol. 2006 Dec;87(6):475-83.
66. Ortlepp JR, etal., J Mol Med. 2003 Jun;81(6):363-7. Epub 2003 Apr 29.
67. Peters W, etal., Proc Natl Acad Sci U S A 2001 Jul 3;98(14):7958-63.
68. Petrkova J, etal., Immunol Lett. 2003 Jul 3;88(1):53-5.
69. Pipeline to import KEGG annotations from KEGG into RGD
70. Pokkali S, etal., FEMS Immunol Med Microbiol. 2009 Apr;55(3):352-60. Epub 2009 Jan 12.
71. Qiu Y, etal., Cell. 2014 Jun 5;157(6):1292-308. doi: 10.1016/j.cell.2014.03.066.
72. RGD automated data pipeline
73. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
74. RGD automated import pipeline for gene-chemical interactions
75. Rittig K, etal., Atherosclerosis. 2008 Jun;198(2):338-46. Epub 2007 Dec 21.
76. Sato N, etal., J Exp Med. 2000 Jul 17;192(2):205-18.
77. Sautter NB, etal., J Assoc Res Otolaryngol. 2006 Dec;7(4):361-72. Epub 2006 Oct 31.
78. Sawada A, etal., Pain. 2014 Jun 4. pii: S0304-3959(14)00264-4. doi: 10.1016/j.pain.2014.05.031.
79. Sbrana S, etal., Cytometry B Clin Cytom. 2005 May;65(1):14-21.
80. Seitz DH, etal., Crit Care Med. 2010 Sep;38(9):1852-9.
81. Sennlaub F, etal., EMBO Mol Med. 2013 Nov;5(11):1775-93. doi: 10.1002/emmm.201302692. Epub 2013 Oct 21.
82. Shahrara S, etal., Arthritis Rheum. 2003 Dec;48(12):3568-83.
83. Shao Z, etal., J Immunol. 2009 Dec 1;183(11):7531-8. doi: 10.4049/jimmunol.0901341. Epub 2009 Nov 16.
84. Silva TA, etal., Oral Microbiol Immunol. 2005 Oct;20(5):310-6.
85. Sivakumar V, etal., J Pathol. 2011 Jan 17. doi: 10.1002/path.2858.
86. Sonekatsu M, etal., Mol Pain. 2016 Apr 18;12. pii: 12/0/1744806916644927. doi: 10.1177/1744806916644927. Print 2016.
87. Soto-Sanchez J, etal., Cytokine. 2010 May;50(2):114-6. doi: 10.1016/j.cyto.2010.01.006. Epub 2010 Feb 12.
88. Spagnolo P, etal., J Intern Med. 2008 Nov;264(5):433-41. Epub 2008 May 29.
89. Spinetti G, etal., Arterioscler Thromb Vasc Biol. 2004 Aug;24(8):1397-402. Epub 2004 Jun 3.
90. Szalai C, etal., Pediatr Res. 1999 Jul;46(1):82-4.
91. Valdes AM, etal., Arterioscler Thromb Vasc Biol. 2002 Nov 1;22(11):1924-8.
92. van Gassen KL, etal., Eur J Neurosci. 2005 Jun;21(11):2949-57.
93. Venza I, etal., J Periodontol. 2010 Jan;81(1):99-108. doi: 10.1902/jop.2009.090358.
94. Vestergaard C, etal., Acta Derm Venereol. 2004;84(5):353-8.
95. White FA, etal., Proc Natl Acad Sci U S A. 2005 Sep 27;102(39):14092-7. Epub 2005 Sep 20.
96. Xie P, etal., PLoS One. 2011;6(12):e28933. doi: 10.1371/journal.pone.0028933. Epub 2011 Dec 19.
97. Yamamoto T and Nishioka K, J Invest Dermatol. 2003 Sep;121(3):510-6.
98. Yang D, etal., Respir Physiol Neurobiol. 2010 Mar 31;170(3):253-9. Epub 2010 Feb 10.
99. Yang SJ, etal., Diabetologia. 2009 May;52(5):972-81. doi: 10.1007/s00125-009-1309-8. Epub 2009 Mar 10.
100. Zhang C and Guo L, Wei Sheng Yan Jiu. 2015 Sep;44(5):730-7.
101. Zhang J, etal., J Surg Res. 2016 May 15;202(2):352-62. doi: 10.1016/j.jss.2016.02.029. Epub 2016 Mar 3.
102. Zhang M, etal., Am J Hypertens. 2006 Jan;19(1):67-72.
103. Zhang R, etal., J Neuroimmunol. 2006 Oct;179(1-2):87-93. Epub 2006 Jul 20.
104. Zhang RX, etal., J Investig Allergol Clin Immunol. 2007;17(5):329-36.
105. Zhang ZJ, etal., J Neuroinflammation. 2012 Jul 9;9:136. doi: 10.1186/1742-2094-9-136.
106. Zhu X, etal., J Pain. 2014 May;15(5):516-26. doi: 10.1016/j.jpain.2014.01.492. Epub 2014 Jan 23.
107. Zhu XL, etal., Chin J Dent Res. 2010;13(2):109-14.
Additional References at PubMed
PMID:8631787   PMID:8662823   PMID:8996246   PMID:9342361   PMID:9366570   PMID:10657654   PMID:10854218   PMID:10993920   PMID:12271471   PMID:12808141   PMID:14566334   PMID:15995708  
PMID:16148108   PMID:17484785   PMID:18421085   PMID:18586982   PMID:18587271   PMID:18832716   PMID:20034406   PMID:20234092   PMID:21143971   PMID:22466130   PMID:23049171   PMID:23288990  
PMID:23594826   PMID:23610400   PMID:23913046   PMID:24806994   PMID:26062549   PMID:28507030   PMID:29142497   PMID:29359616   PMID:29632244   PMID:29930553   PMID:29993042   PMID:30201767  
PMID:31034839   PMID:31805255   PMID:32164451   PMID:32650794  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.28123,734,465 - 123,742,483 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl8123,734,430 - 123,742,100 (+)Ensembl
RGSC_v3.48128,892,784 - 128,893,905 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18128,912,520 - 128,913,642 (+)NCBI
Celera8122,833,545 - 122,834,666 (+)NCBICelera
Cytogenetic Map8q32NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl346,353,864 - 46,360,940 (+)EnsemblGRCh38hg38GRCh38
GRCh38346,354,111 - 46,360,940 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37346,395,602 - 46,402,431 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36346,370,364 - 46,377,432 (+)NCBINCBI36hg18NCBI36
Celera346,332,557 - 46,339,734 (+)NCBI
Cytogenetic Map3p21.31NCBI
HuRef346,438,874 - 46,446,051 (+)NCBIHuRef
CHM1_1346,345,233 - 46,352,410 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm399123,901,954 - 123,913,594 (+)NCBIGRCm39mm39
GRCm39 Ensembl9123,901,987 - 123,913,594 (+)Ensembl
GRCm389124,101,918 - 124,109,140 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9124,101,950 - 124,113,557 (+)EnsemblGRCm38mm10GRCm38
MGSCv379124,016,922 - 124,023,879 (+)NCBIGRCm37mm9NCBIm37
MGSCv369123,950,982 - 123,957,349 (+)NCBImm8
Celera9124,890,502 - 124,897,441 (-)NCBICelera
Cytogenetic Map9F4NCBI
cM Map975.05NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0NW_00495542025,641,184 - 25,664,413 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.1347,361,118 - 47,368,312 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl347,361,124 - 47,368,312 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0346,255,725 - 46,263,285 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.12042,305,344 - 42,313,258 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2042,307,580 - 42,308,698 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2042,220,658 - 42,229,191 (-)NCBI
ROS_Cfam_1.02042,787,203 - 42,795,751 (-)NCBI
ROS_Cfam_1.0 Ensembl2042,787,205 - 42,793,246 (-)Ensembl
UMICH_Zoey_3.12042,028,417 - 42,036,962 (-)NCBI
UNSW_CanFamBas_1.02042,429,835 - 42,438,385 (-)NCBI
UU_Cfam_GSD_1.02042,710,738 - 42,719,282 (-)NCBI
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1329,251,959 - 29,376,346 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11329,368,735 - 29,374,564 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21332,532,565 - 32,538,394 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1227,795,192 - 7,801,242 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl227,798,646 - 7,799,728 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041159,351,063 - 159,358,108 (-)NCBIVero_WHO_p1.0

Position Markers
Rat AssemblyChrPosition (strand)SourceJBrowse
RGSC_v3.48128,893,811 - 128,893,893UniSTSRGSC3.4
Celera8122,834,572 - 122,834,654UniSTS
Cytogenetic Map8q32UniSTS

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat

Genetic Models
This gene Ccr2 is modified in the following models/strains



Reference Sequences
RefSeq Acc Id: ENSRNOT00000100998   ⟹   ENSRNOP00000095594
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,734,430 - 123,742,100 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000114724   ⟹   ENSRNOP00000081733
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8123,735,941 - 123,742,100 (+)Ensembl
RefSeq Acc Id: NM_021866   ⟹   NP_068638
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,738,248 - 123,739,369 (+)NCBI
RGSC_v3.48128,892,784 - 128,893,905 (+)RGD
Celera8122,833,545 - 122,834,666 (+)RGD
RefSeq Acc Id: XM_039082059   ⟹   XP_038937987
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,735,394 - 123,741,686 (+)NCBI
RefSeq Acc Id: XM_039082060   ⟹   XP_038937988
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,734,470 - 123,741,686 (+)NCBI
RefSeq Acc Id: XM_039082061   ⟹   XP_038937989
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,735,404 - 123,741,686 (+)NCBI
RefSeq Acc Id: XM_039082062   ⟹   XP_038937990
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,734,465 - 123,741,686 (+)NCBI
RefSeq Acc Id: XM_039082063   ⟹   XP_038937991
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,734,465 - 123,741,686 (+)NCBI
RefSeq Acc Id: XM_039082064   ⟹   XP_038937992
RefSeq Status:
Rat AssemblyChrPosition (strand)Source
mRatBN7.28123,735,350 - 123,742,483 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_068638   ⟸   NM_021866
- UniProtKB: O55193 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_038937990   ⟸   XM_039082062
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038937991   ⟸   XM_039082063
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038937988   ⟸   XM_039082060
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038937992   ⟸   XM_039082064
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038937987   ⟸   XM_039082059
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038937989   ⟸   XM_039082061
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000095594   ⟸   ENSRNOT00000100998
RefSeq Acc Id: ENSRNOP00000081733   ⟸   ENSRNOT00000114724


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSRNOG00000063127 Ensembl, ENTREZGENE
Ensembl Protein ENSRNOP00000081733 ENTREZGENE
Ensembl Transcript ENSRNOT00000100998 ENTREZGENE
InterPro Chemokine_CCR2 UniProtKB/Swiss-Prot
  Chemokine_rcpt UniProtKB/Swiss-Prot
  GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
KEGG Report rno:60463 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Ccr2 PhenoGen
  CHEMOKINER2 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
UniProt CCR2_RAT UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-22 Ccr2  C-C motif chemokine receptor 2  Ccr2  chemokine (C-C motif) receptor 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Ccr2  chemokine (C-C motif) receptor 2    chemokine receptor CCR2 gene  Name updated 1299863 APPROVED
2002-08-07 Ccr2  chemokine receptor CCR2 gene      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in spleen, lung, kidney, thymus, and macrophages 632391
gene_regulation increased after induction of experimental allergic encephalomyelitis (EAE) 632391