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Gene: Itpr2 (inositol 1,4,5-trisphosphate receptor, type 2) Rattus norvegicus
Symbol: Itpr2
Name: inositol 1,4,5-trisphosphate receptor, type 2
Description: Exhibits calcium ion binding activity; inositol 1,4,5 trisphosphate binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in cellular response to hypoxia and release of sequestered calcium ion into cytosol. Localizes to several cellular components, including the endoplasmic reticulum membrane; myelin sheath; and sarcoplasmic reticulum. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
Also known as: inositol 1,4,5-triphosphate receptor 2; inositol 1,4,5-triphosphate receptor type 2; inositol 1,4,5-triphosphate receptor, type 2; inositol 1,4,5-trisphosphate receptor type 2; inositol 145-triphosphate receptor type 2; inositol triphosphate receptor type 2; insP3R2; IP3 receptor; IP3R 2; type 2 inositol 1,4,5-trisphosphate receptor; type 2 InsP3 receptor
Homo sapiens (human) : ITPR2 (inositol 1,4,5-trisphosphate receptor type 2)  HGNC  Alliance
Mus musculus (house mouse) : Itpr2 (inositol 1,4,5-triphosphate receptor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itpr2 (inositol 1,4,5-trisphosphate receptor type 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ITPR2 (inositol 1,4,5-trisphosphate receptor type 2)
Canis lupus familiaris (dog) : ITPR2 (inositol 1,4,5-trisphosphate receptor type 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itpr2 (inositol 1,4,5-trisphosphate receptor type 2)
Sus scrofa (pig) : ITPR2 (inositol 1,4,5-trisphosphate receptor type 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.04180,423,452 - 180,800,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4180,538,389 - 180,722,358 (-)Ensembl
Rnor_5.04244,585,711 - 244,960,429 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44183,677,606 - 184,066,130 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14183,922,730 - 184,311,254 (-)NCBI
Celera4167,526,971 - 167,901,481 (-)NCBICelera
Cytogenetic Map4q44NCBI
RH 3.4 Map41070.3RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Itpr2
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69649
Created: 2001-12-06
Species: Rattus norvegicus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.