Gene: Itpr2 (inositol 1,4,5-trisphosphate receptor, type 2) Rattus norvegicus
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Symbol: Itpr2
Name: inositol 1,4,5-trisphosphate receptor, type 2
Description: Exhibits calcium ion binding activity; inositol 1,4,5 trisphosphate binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in cellular response to hypoxia and release of sequestered calcium ion into cytosol. Localizes to the axon; endoplasmic reticulum; and myelin sheath. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis and isolated anhidrosis with normal sweat glands. Orthologous to human ITPR2 (inositol 1,4,5-trisphosphate receptor type 2); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; Alzheimer's disease pathway; INTERACTS WITH 2,4,6-trinitrobenzenesulfonic acid; 2,6-dinitrotoluene; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: inositol 1,4,5-triphosphate receptor 2; inositol 1,4,5-triphosphate receptor type 2; inositol 1,4,5-triphosphate receptor, type 2; inositol 1,4,5-trisphosphate receptor type 2; inositol 145-triphosphate receptor type 2; inositol triphosphate receptor type 2; insP3R2; IP3 receptor; IP3R 2; type 2 inositol 1,4,5-trisphosphate receptor; type 2 InsP3 receptor
Orthologs:
Homo sapiens (human) : ITPR2 (inositol 1,4,5-trisphosphate receptor type 2)  HGNC  Alliance
Mus musculus (house mouse) : Itpr2 (inositol 1,4,5-triphosphate receptor 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itpr2 (inositol 1,4,5-trisphosphate receptor type 2)
Pan paniscus (bonobo/pygmy chimpanzee) : ITPR2 (inositol 1,4,5-trisphosphate receptor type 2)
Canis lupus familiaris (dog) : ITPR2 (inositol 1,4,5-trisphosphate receptor type 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itpr2 (inositol 1,4,5-trisphosphate receptor type 2)
Sus scrofa (pig) : ITPR2 (inositol 1,4,5-trisphosphate receptor type 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.04180,423,452 - 180,800,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.04244,585,711 - 244,960,429 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44183,677,606 - 184,066,130 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.14183,922,730 - 184,311,254 (-)NCBI
Celera4167,526,971 - 167,901,481 (-)NCBICelera
Cytogenetic Map4q44NCBI
RH 3.4 Map41070.3RGD
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

Comparative Map Data
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QTLs in Region (Rnor_6.0)
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Sequence

Nucleotide Sequences
Protein Sequences

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Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
  
More on Itpr2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 69649
Created: 2001-12-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.