RGD Reference Report - Structure of a novel InsP3 receptor. - Rat Genome Database

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Structure of a novel InsP3 receptor.

Authors: Sudhof, TC  Newton, CL  Archer BT, 3RD  Ushkaryov, YA  Mignery, GA 
Citation: Sudhof TC, etal., EMBO J 1991 Nov;10(11):3199-206.
RGD ID: 68894
Pubmed: PMID:1655411   (View Abstract at PubMed)
PMCID: PMC453043   (View Article at PubMed Central)

Inositol 1,4,5-trisphosphate (InsP3) constitutes a major intracellular second messenger that transduces many growth factor and neurotransmitter signals. InsP3 causes the release of Ca2+ from intracellular stores by binding to specific receptors that are coupled to Ca2+ channels. One such receptor from cerebellum has previously been extensively characterized. We have now determined the full structure of a second, novel InsP3 receptor which we refer to as type 2 InsP3 receptor as opposed to the cerebellar type 1 InsP3 receptor. The type 2 InsP3 receptor has the same general structural design as the cerebellar type 1 InsP3 receptor with which it shares 69% sequence identity. Expression of the amino-terminal 1078 amino acids of the type 2 receptor demonstrates high affinity binding of InsP3 to the type 2 receptor with a similar specificity but higher affinity than observed for the type 1 receptor. These results demonstrate the presence of several types of InsP3 receptor in brain and raise the possibility that intracellular Ca2+ signaling may involve multiple pathways with different regulatory properties dependent on different InsP3 receptors.



Objects referenced in this article
Gene Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 Rattus norvegicus

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