Itpr2 (inositol 1,4,5-trisphosphate receptor type 2) - Rat Genome Database

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Gene: Itpr2 (inositol 1,4,5-trisphosphate receptor type 2) Chinchilla lanigera
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Symbol: Itpr2
Name: inositol 1,4,5-trisphosphate receptor type 2
RGD ID: 8744673
Description: ENCODES a protein that exhibits calcium ion binding (ortholog); inositol 1,4,5 trisphosphate binding (ortholog); inositol 1,4,5-trisphosphate-gated calcium channel activity (ortholog); INVOLVED IN calcium ion transport (ortholog); cellular response to cAMP (ortholog); cellular response to ethanol (ortholog); PARTICIPATES IN calcium transport pathway; calcium/calcium-mediated signaling pathway; ASSOCIATED WITH amyotrophic lateral sclerosis (ortholog); Brain Hypoxia (ortholog); Cardiomegaly (ortholog); FOUND IN axon (ortholog); cell cortex (ortholog); cytoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: inositol 1,4,5-trisphosphate receptor, type 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541321,291,110 - 21,719,303 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541321,289,673 - 21,719,610 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Itpr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541321,291,110 - 21,719,303 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541321,289,673 - 21,719,610 (-)NCBIChiLan1.0ChiLan1.0
ITPR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381226,335,352 - 26,833,194 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1226,335,352 - 26,833,194 (-)EnsemblGRCh38hg38GRCh38
GRCh371226,488,285 - 26,986,127 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361226,379,552 - 26,877,398 (-)NCBINCBI36Build 36hg18NCBI36
Build 341226,381,611 - 26,877,398NCBI
Celera1231,634,797 - 32,132,275 (-)NCBICelera
Cytogenetic Map12p11.23NCBI
HuRef1226,258,420 - 26,756,231 (-)NCBIHuRef
CHM1_11226,453,424 - 26,951,168 (-)NCBICHM1_1
T2T-CHM13v2.01226,207,897 - 26,705,197 (-)NCBIT2T-CHM13v2.0
Itpr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396146,009,797 - 146,403,757 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6146,009,797 - 146,403,721 (-)EnsemblGRCm39 Ensembl
GRCm386146,108,299 - 146,502,258 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6146,108,299 - 146,502,223 (-)EnsemblGRCm38mm10GRCm38
MGSCv376146,060,002 - 146,450,434 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366146,068,650 - 146,459,082 (-)NCBIMGSCv36mm8
Celera6149,142,524 - 149,540,657 (-)NCBICelera
Cytogenetic Map6G3NCBI
cM Map677.7NCBI
Itpr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84180,759,325 - 181,165,361 (-)NCBIGRCr8
mRatBN7.24179,028,594 - 179,434,657 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4179,027,281 - 179,404,164 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4185,313,424 - 185,690,245 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04181,097,944 - 181,474,767 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04179,718,376 - 180,095,194 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04180,423,452 - 180,800,088 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4180,538,389 - 180,722,358 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04244,585,711 - 244,960,429 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44183,677,606 - 184,066,130 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14183,922,730 - 184,311,254 (-)NCBI
Celera4167,526,971 - 167,901,481 (-)NCBICelera
RH 3.4 Map41070.3RGD
Cytogenetic Map4q44NCBI
ITPR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21069,981,191 - 70,487,626 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11269,978,015 - 70,484,024 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01259,478,206 - 59,984,572 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11262,093,208 - 62,596,018 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1262,092,241 - 62,596,018 (+)Ensemblpanpan1.1panPan2
ITPR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12720,806,670 - 21,278,638 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2720,805,842 - 21,350,083 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2725,103,914 - 25,581,983 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02721,001,355 - 21,474,042 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2721,001,392 - 21,471,311 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12720,812,377 - 21,283,928 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02720,834,447 - 21,306,590 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02725,271,849 - 25,744,599 (-)NCBIUU_Cfam_GSD_1.0
Itpr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494582,723,135 - 83,198,963 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936548645,925 - 1,121,888 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936548646,019 - 1,120,426 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITPR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl546,935,932 - 47,464,125 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1546,935,923 - 47,465,681 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2550,482,341 - 50,738,864 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ITPR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11126,089,480 - 26,574,621 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1126,089,484 - 26,574,950 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660698,498,077 - 8,981,050 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itpr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475212,360,740 - 12,822,287 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475212,360,796 - 12,820,042 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_013511399 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AGCD01014249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014250 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014251 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014252 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014253 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014254 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014256 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014258 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014259 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014260 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AGCD01014261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBBH01228681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GBDI01225022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSCLAT00000025238   ⟹   ENSCLAP00000024994
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541321,291,110 - 21,719,303 (-)Ensembl
RefSeq Acc Id: XM_013511399   ⟹   XP_013366853
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541321,289,673 - 21,719,610 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_013366853 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000024994
  ENSCLAP00000024994.1
RefSeq Acc Id: XP_013366853   ⟸   XM_013511399
- UniProtKB: A0A8C2WCN8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000024994   ⟸   ENSCLAT00000025238
Protein Domains
MIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000017155 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000025238 ENTREZGENE
  ENSCLAT00000025238.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.287.70 UniProtKB/TrEMBL
  2.80.10.50 UniProtKB/TrEMBL
  IP3 receptor type 1 binding core, RIH domain UniProtKB/TrEMBL
InterPro ARM-type_fold UniProtKB/TrEMBL
  Ins145_P3_rcpt UniProtKB/TrEMBL
  InsP3_rcpt UniProtKB/TrEMBL
  Ion_trans_dom UniProtKB/TrEMBL
  MIR_dom_sf UniProtKB/TrEMBL
  MIR_motif UniProtKB/TrEMBL
  RIH_assoc-dom UniProtKB/TrEMBL
  RIH_dom UniProtKB/TrEMBL
  Ryanodine_IP3_receptor UniProtKB/TrEMBL
  RyR/IP3R_RIH_dom_sf UniProtKB/TrEMBL
NCBI Gene Itpr2 ENTREZGENE
PANTHER INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR TYPE 2 UniProtKB/TrEMBL
  MIR DOMAIN-CONTAINING PROTEIN UniProtKB/TrEMBL
Pfam Ins145_P3_rec UniProtKB/TrEMBL
  Ion_trans UniProtKB/TrEMBL
  MIR UniProtKB/TrEMBL
  RIH_assoc UniProtKB/TrEMBL
  RYDR_ITPR UniProtKB/TrEMBL
PRINTS INSP3RECEPTR UniProtKB/TrEMBL
PROSITE MIR UniProtKB/TrEMBL
SMART MIR UniProtKB/TrEMBL
Superfamily-SCOP SSF100909 UniProtKB/TrEMBL
  SSF48371 UniProtKB/TrEMBL
  SSF82109 UniProtKB/TrEMBL
UniProt A0A8C2WCN8 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-03 Itpr2  inositol 1,4,5-trisphosphate receptor type 2    inositol 1,4,5-trisphosphate receptor, type 2  Symbol and/or name change 5135510 APPROVED