RGD Reference Report - Immobilization stress elevates IP(3) receptor mRNA in adult rat hearts in a glucocorticoid-dependent manner. - Rat Genome Database

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Immobilization stress elevates IP(3) receptor mRNA in adult rat hearts in a glucocorticoid-dependent manner.

Authors: Lencesova, L  Ondrias, K  Micutkova, L  Filipenko, M  Kvetnansky, R  Krizanova, O 
Citation: Lencesova L, etal., FEBS Lett 2002 Nov 20;531(3):432-6.
RGD ID: 729245
Pubmed: PMID:12435588   (View Abstract at PubMed)

Gene expression of the type 1 and 2 inositol 1,4,5-trisphosphate (IP(3)) receptors in the rat cardiac atria and ventricles and their possible modulation by single immobilization stress was studied. Single immobilization stress significantly elevated mRNA levels for both types of these receptors. To evaluate the involvement of glucocorticoids in the modulation of the gene expression of IP(3) receptors by immobilization stress, we used adrenalectomized and/or hypophysectomized rats. Since adrenalectomy and/or hypophysectomy completely abolished increase in IP(3) receptor's mRNA levels after the immobilization, we conclude that immobilization stress elevates mRNA of type 1 and 2 IP(3) receptors, mainly through the glucocorticoid responsive element.



Gene Itpr1 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus
Gene Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 Rattus norvegicus