Diaph3 (diaphanous-related formin 3) - Rat Genome Database

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Gene: Diaph3 (diaphanous-related formin 3) Rattus norvegicus
Analyze
Symbol: Diaph3
Name: diaphanous-related formin 3
RGD ID: 1593287
Description: Predicted to enable actin binding activity and small GTPase binding activity. Involved in spermatogenesis. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in autosomal dominant auditory neuropathy 1. Orthologous to human DIAPH3 (diaphanous related formin 3); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Diap3; diaphanous homolog 3; diaphanous homolog 3 (Drosophila); DRF3; LOC290396; mDIA2; similar to Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (mDIA2) (p134mDIA2)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: Diaph3Tn(sb-T2/Bart3)2.318Mcwi  
Genetic Models: F344-Diaph3Tn(sb-T2/Bart3)2.318Mcwi
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21562,543,375 - 63,013,060 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1562,543,375 - 63,012,975 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1566,656,922 - 67,116,561 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01567,742,429 - 68,202,078 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01564,634,100 - 65,103,658 (-)NCBIRnor_WKY
Rnor_6.01569,928,507 - 70,400,077 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1570,039,424 - 70,399,924 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01573,538,942 - 74,007,617 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41568,905,784 - 69,267,707 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1562,058,201 - 62,525,728 (-)NCBICelera
Cytogenetic Map15q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bisphenol A  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dioxygen  (EXP,ISO)
doxorubicin  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethyl methanesulfonate  (ISO)
fenvalerate  (EXP)
formaldehyde  (ISO)
gentamycin  (EXP)
indole-3-methanol  (EXP)
indometacin  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
lucanthone  (ISO)
MeIQx  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenformin  (EXP)
PhIP  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propanal  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
senecionine  (EXP)
Senkirkine  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
testosterone  (EXP,ISO)
tetrachloromethane  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP)
topotecan  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
trovafloxacin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
actin filament  (IBA)
cytoplasm  (IDA,ISO)
nucleus  (IDA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Expression of the diaphanous-related formin proteins mDia1 and mDia2 in the rat testis. Mironova E and Millette CF, Dev Dyn. 2008 Aug;237(8):2170-6.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:19117945   PMID:20624953   PMID:23558171   PMID:25468996  


Genomics

Comparative Map Data
Diaph3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21562,543,375 - 63,013,060 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1562,543,375 - 63,012,975 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1566,656,922 - 67,116,561 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01567,742,429 - 68,202,078 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01564,634,100 - 65,103,658 (-)NCBIRnor_WKY
Rnor_6.01569,928,507 - 70,400,077 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1570,039,424 - 70,399,924 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01573,538,942 - 74,007,617 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41568,905,784 - 69,267,707 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1562,058,201 - 62,525,728 (-)NCBICelera
Cytogenetic Map15q12NCBI
DIAPH3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381359,665,583 - 60,163,928 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1359,665,583 - 60,163,928 (-)EnsemblGRCh38hg38GRCh38
GRCh371360,239,717 - 60,738,062 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361359,137,718 - 59,636,120 (-)NCBINCBI36Build 36hg18NCBI36
Build 341359,246,300 - 59,485,300NCBI
Celera1341,197,875 - 41,696,297 (-)NCBICelera
Cytogenetic Map13q21.2NCBI
HuRef1341,255,633 - 41,428,315 (-)NCBIHuRef
HuRef1340,931,297 - 41,246,568 (-)NCBIHuRef
CHM1_11360,207,261 - 60,705,825 (-)NCBICHM1_1
T2T-CHM13v2.01358,885,077 - 59,383,567 (-)NCBIT2T-CHM13v2.0
Diaph3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391486,892,793 - 87,378,683 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1486,892,803 - 87,378,671 (-)EnsemblGRCm39 Ensembl
GRCm381486,655,357 - 87,141,247 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1486,655,367 - 87,141,235 (-)EnsemblGRCm38mm10GRCm38
MGSCv371487,056,130 - 87,540,921 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361485,488,070 - 85,972,861 (-)NCBIMGSCv36mm8
Celera1484,160,281 - 84,666,148 (-)NCBICelera
Cytogenetic Map14E1NCBI
Diaph3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540444,653,501 - 45,105,966 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540444,653,308 - 45,106,943 (+)NCBIChiLan1.0ChiLan1.0
DIAPH3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11359,568,025 - 60,056,893 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1359,676,307 - 60,056,672 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01340,846,270 - 41,335,920 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
DIAPH3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12215,573,485 - 16,078,580 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2215,573,629 - 16,079,031 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2215,549,820 - 16,056,525 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02215,808,339 - 16,315,836 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2215,808,334 - 16,315,281 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12215,507,946 - 16,015,886 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02215,533,302 - 16,040,579 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02215,547,618 - 16,055,719 (-)NCBIUU_Cfam_GSD_1.0
Diaph3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404945144,087,524 - 144,542,722 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367051,380,445 - 1,731,280 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049367051,381,025 - 1,833,890 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DIAPH3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1132,492,740 - 32,994,844 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11132,492,735 - 32,994,854 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21134,600,374 - 34,681,530 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DIAPH3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1337,455,326 - 37,951,237 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_0236660575,747,366 - 6,261,536 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Diaph3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474821,045,085 - 21,383,605 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474820,937,242 - 21,439,554 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Diaph3
1763 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:20
Count of miRNA genes:19
Interacting mature miRNAs:20
Transcripts:ENSRNOT00000012167
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)152803066582262678Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)152803066582262678Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)152803066582262678Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)152803066582262678Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153361105871477291Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153361105871477291Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)153405413979054139Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)154063126898288169Rat
724545Niddm54Non-insulin dependent diabetes mellitus QTL 540.02blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)155079449473699215Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)155284790873690657Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)155380615298806152Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)155559608991365858Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)155559608995018120Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1558156477101769107Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)156099046873690657Rat

Markers in Region
D15Rat125  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21562,725,486 - 62,725,621 (+)MAPPERmRatBN7.2
Rnor_6.01570,113,265 - 70,113,399NCBIRnor6.0
Rnor_5.01573,722,226 - 73,722,360UniSTSRnor5.0
RGSC_v3.41568,977,804 - 68,977,939RGDRGSC3.4
RGSC_v3.41568,977,805 - 68,977,939UniSTSRGSC3.4
RGSC_v3.11568,993,584 - 68,993,719RGD
Celera1562,240,269 - 62,240,403UniSTS
SHRSP x BN Map1540.2698RGD
SHRSP x BN Map1540.2698UniSTS
Cytogenetic Map15q12UniSTS
D15Rat150  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera1562,096,879 - 62,097,089UniSTS
RH 3.4 Map15388.63UniSTS
RH 3.4 Map15388.63RGD
SHRSP x BN Map1539.1899UniSTS
SHRSP x BN Map1539.1899RGD
Cytogenetic Map15q12UniSTS
D15Got225  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21562,594,641 - 62,594,908 (+)MAPPERmRatBN7.2
Rnor_6.01569,980,584 - 69,980,850NCBIRnor6.0
Rnor_5.01573,591,185 - 73,591,451UniSTSRnor5.0
RGSC_v3.41568,846,714 - 68,846,980UniSTSRGSC3.4
Celera1562,109,148 - 62,109,414UniSTS
Cytogenetic Map15q12UniSTS
RH137283  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21562,543,430 - 62,543,642 (+)MAPPERmRatBN7.2
Rnor_6.01569,928,560 - 69,928,771NCBIRnor6.0
Rnor_5.01573,538,995 - 73,539,206UniSTSRnor5.0
RGSC_v3.41568,795,219 - 68,795,430UniSTSRGSC3.4
RGSC_v3.41568,587,986 - 68,588,197UniSTSRGSC3.4
Celera1562,058,254 - 62,058,465UniSTS
RH 3.4 Map15388.63UniSTS
Cytogenetic Map15q12UniSTS
UniSTS:237232  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21562,543,460 - 62,543,658 (+)MAPPERmRatBN7.2
Rnor_6.01569,928,590 - 69,928,787NCBIRnor6.0
Rnor_5.01573,539,025 - 73,539,222UniSTSRnor5.0
RGSC_v3.41568,587,970 - 68,588,167UniSTSRGSC3.4
RGSC_v3.41568,795,249 - 68,795,446UniSTSRGSC3.4
Celera1562,058,284 - 62,058,481UniSTS
Cytogenetic Map15q12UniSTS


Genetic Models
This gene Diaph3 is modified in the following models/strains

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 22 26 20 12 20 14 16 34
Low 3 16 22 13 7 13 4 4 54 14 7 11 4
Below cutoff 5 9 8 8 4 7 6 5 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000012167   ⟹   ENSRNOP00000012167
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1562,543,378 - 63,012,975 (-)Ensembl
Rnor_6.0 Ensembl1570,039,424 - 70,349,983 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087940   ⟹   ENSRNOP00000074783
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1570,349,804 - 70,399,924 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000103316   ⟹   ENSRNOP00000082597
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1562,543,375 - 62,608,052 (-)Ensembl
RefSeq Acc Id: NM_001305172   ⟹   NP_001292101
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21562,543,378 - 63,012,975 (-)NCBI
Rnor_6.01569,928,507 - 70,399,988 (-)NCBI
Celera1562,058,201 - 62,525,728 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017599638   ⟹   XP_017455127
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21562,543,375 - 63,013,060 (-)NCBI
Rnor_6.01569,928,507 - 70,400,077 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093178   ⟹   XP_038949106
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21562,543,375 - 63,012,360 (-)NCBI
RefSeq Acc Id: XM_039093179   ⟹   XP_038949107
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21562,543,375 - 63,012,480 (-)NCBI
RefSeq Acc Id: XM_039093180   ⟹   XP_038949108
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21562,543,375 - 62,871,231 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001292101   ⟸   NM_001305172
- UniProtKB: A0A0G2K8Y4 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017455127   ⟸   XM_017599638
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000012167   ⟸   ENSRNOT00000012167
RefSeq Acc Id: ENSRNOP00000074783   ⟸   ENSRNOT00000087940
RefSeq Acc Id: XP_038949107   ⟸   XM_039093179
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949106   ⟸   XM_039093178
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949108   ⟸   XM_039093180
- Peptide Label: isoform X3
RefSeq Acc Id: ENSRNOP00000082597   ⟸   ENSRNOT00000103316
Protein Domains
DAD   FH1   FH2   GBD/FH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1LVW7-F1-model_v2 AlphaFold F1LVW7 1-1172 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699856
Promoter ID:EPDNEW_R10378
Type:multiple initiation site
Name:Diaph3_1
Description:diaphanous-related formin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01570,400,004 - 70,400,064EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593287 AgrOrtholog
BioCyc Gene G2FUF-12934 BioCyc
Ensembl Genes ENSRNOG00000008986 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000012167 ENTREZGENE
  ENSRNOP00000012167.8 UniProtKB/TrEMBL
  ENSRNOP00000082597.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000012167 ENTREZGENE
  ENSRNOT00000012167.8 UniProtKB/TrEMBL
  ENSRNOT00000103316.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.20.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.58.2220 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro ARM-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ARM-type_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAD_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DIA_GBD_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FH2_Formin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FH2_Formin_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FH3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Formin_DIAPH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GBD/FH3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GTPase-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:290396 UniProtKB/Swiss-Prot
NCBI Gene 290396 ENTREZGENE
PANTHER PTHR45691:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Drf_FH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Drf_GBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Diaph3 PhenoGen
PROSITE DAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GBD_FH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Drf_FH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Drf_GBD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FH2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K8Y4 ENTREZGENE
  A0A3B4PZE1_RAT UniProtKB/TrEMBL
  A0A8I5ZXD1_RAT UniProtKB/TrEMBL
  DIAP3_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A0A0G2K8Y4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-26 Diaph3  diaphanous homolog 3 (Drosophila)  Diap3  diaphanous homolog 3 (Drosophila)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Diap3  diaphanous homolog 3 (Drosophila)  LOC290396  similar to Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (mDIA2) (p134mDIA2)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC290396  similar to Protein diaphanous homolog 3 (Diaphanous-related formin-3) (DRF3) (mDIA2) (p134mDIA2)      Symbol and Name status set to provisional 70820 PROVISIONAL