Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | CCNC (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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Imported Disease Annotations - ClinVarTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | genetic disease | | ISO | CCNC (Homo sapiens) | 8554872 | ClinVar Annotator: match by term: Inborn genetic diseases | ClinVar | | |
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# | Reference Title | Reference Citation |
1. | Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase. | Brower CS, etal., Proc Natl Acad Sci U S A. 2002 Aug 6;99(16):10353-8. Epub 2002 Jul 29. |
2. | Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). | Demetrick DJ, etal., Cytogenet Cell Genet 1995;69(3-4):190-2. |
3. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
4. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
5. | Molecular cloning and chromosomal localization of the human cyclin C (CCNC) and cyclin E (CCNE) genes: deletion of the CCNC gene in human tumors. | Li H, etal., Genomics 1996 Mar 1;32(2):253-9. |
6. | Gene Data Set | MGD Curation, June 12, 2002 |
7. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
8. | Electronic Transfer of LocusLink and RefSeq Data | NCBI rat LocusLink and RefSeq merged data July 26, 2002 |
9. | The Mediator complex and transcription regulation. | Poss ZC, etal., Crit Rev Biochem Mol Biol. 2013 Nov-Dec;48(6):575-608. doi: 10.3109/10409238.2013.840259. Epub 2013 Oct 3. |
10. | GOA pipeline | RGD automated data pipeline |
11. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
12. | Comprehensive gene review and curation | RGD comprehensive gene curation |
13. | Cyclin G: a new mammalian cyclin with homology to fission yeast Cig1. | Tamura K, etal., Oncogene 1993 Aug;8(8):2113-8. |
14. | [Influence of aerosols on the expression of cyclin B1, cyclin C and proliferating cell nuclear antigen in wound tissue healing of burned rat models] | Zhang T, etal., Zhonghua Wai Ke Za Zhi. 2005 Oct 1;43(19):1280-3. |
15. | Regulation of lipogenesis by cyclin-dependent kinase 8-mediated control of SREBP-1. | Zhao X, etal., J Clin Invest. 2012 Jul 2;122(7):2417-27. doi: 10.1172/JCI61462. Epub 2012 Jun 11. |
Ccnc (Rattus norvegicus - Norway rat) |
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CCNC (Homo sapiens - human) |
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Ccnc (Mus musculus - house mouse) |
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Ccnc (Chinchilla lanigera - long-tailed chinchilla) |
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CCNC (Pan paniscus - bonobo/pygmy chimpanzee) |
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CCNC (Canis lupus familiaris - dog) |
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Ccnc (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CCNC (Sus scrofa - pig) |
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CCNC (Chlorocebus sabaeus - green monkey) |
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Ccnc (Heterocephalus glaber - naked mole-rat) |
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Variants in Ccnc
93 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH129921 |
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RH129977 |
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BI284677 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 3 | 28 | 53 | 37 | 18 | 37 | 1 | 1 | 74 | 34 | 39 | 11 | 1 |
Low | 15 | 4 | 4 | 1 | 4 | 7 | 10 | 1 | 2 | 7 | |||
Below cutoff |
RefSeq Transcripts | NM_001100472 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
XM_006237937 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039109128 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063287061 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063287062 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | BC161908 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
CH473962 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000005 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000011442 ⟹ ENSRNOP00000011442 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000107276 ⟹ ENSRNOP00000095999 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000110130 ⟹ ENSRNOP00000086557 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000112239 ⟹ ENSRNOP00000079034 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001100472 ⟹ NP_001093942 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_006237937 ⟹ XP_006237999 | ||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039109128 ⟹ XP_038965056 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063287061 ⟹ XP_063143131 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | XM_063287062 ⟹ XP_063143132 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_001093942 | (Get FASTA) | NCBI Sequence Viewer |
XP_006237999 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038965056 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063143131 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063143132 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | EDL98512 | (Get FASTA) | NCBI Sequence Viewer |
EDL98513 | (Get FASTA) | NCBI Sequence Viewer | |
EDL98514 | (Get FASTA) | NCBI Sequence Viewer | |
EDL98515 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000011442 | ||
ENSRNOP00000011442.5 | |||
ENSRNOP00000079034.1 | |||
ENSRNOP00000086557 | |||
ENSRNOP00000086557.1 | |||
ENSRNOP00000095999.1 | |||
GenBank Protein | P39947 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001093942 ⟸ NM_001100472 |
- UniProtKB: | P39947 (UniProtKB/Swiss-Prot), G3V738 (UniProtKB/TrEMBL), A6IIE2 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_006237999 ⟸ XM_006237937 |
- Peptide Label: | isoform X2 |
- UniProtKB: | P39947 (UniProtKB/Swiss-Prot), A0A8I6A408 (UniProtKB/TrEMBL), A6IIE3 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000011442 ⟸ ENSRNOT00000011442 |
RefSeq Acc Id: | XP_038965056 ⟸ XM_039109128 |
- Peptide Label: | isoform X2 |
- UniProtKB: | P39947 (UniProtKB/Swiss-Prot), A0A8I6A408 (UniProtKB/TrEMBL), A6IIE3 (UniProtKB/TrEMBL) |
RefSeq Acc Id: | ENSRNOP00000079034 ⟸ ENSRNOT00000112239 |
RefSeq Acc Id: | ENSRNOP00000086557 ⟸ ENSRNOT00000110130 |
RefSeq Acc Id: | ENSRNOP00000095999 ⟸ ENSRNOT00000107276 |
RefSeq Acc Id: | XP_063143131 ⟸ XM_063287061 |
- Peptide Label: | isoform X1 |
RefSeq Acc Id: | XP_063143132 ⟸ XM_063287062 |
- Peptide Label: | isoform X3 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-P39947-F1-model_v2 | AlphaFold | P39947 | 1-278 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13693594 | ||||||||
Promoter ID: | EPDNEW_R4119 | ||||||||
Type: | multiple initiation site | ||||||||
Name: | Ccnc_1 | ||||||||
Description: | cyclin C | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:70905 | AgrOrtholog |
BioCyc Gene | G2FUF-41816 | BioCyc |
Ensembl Genes | ENSRNOG00000007719 | Ensembl, ENTREZGENE, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000011442 | ENTREZGENE |
ENSRNOT00000011442.7 | UniProtKB/TrEMBL | |
ENSRNOT00000107276.1 | UniProtKB/TrEMBL | |
ENSRNOT00000110130.1 | UniProtKB/TrEMBL | |
ENSRNOT00000112239.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | Cyclin-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
InterPro | Cyclin-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Cyclin-like_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Cyclin/Ssn8 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Cyclin_C_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Cyclin_N | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:114839 | UniProtKB/TrEMBL |
NCBI Gene | 114839 | ENTREZGENE |
PANTHER | PTHR10026 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PTHR10026:SF7 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | Cyclin_C_2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Cyclin_N | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Ccnc | PhenoGen |
PIRSF | Cyclin, C/H/G types | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
RatGTEx | ENSRNOG00000007719 | RatGTEx |
SMART | CYCLIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Superfamily-SCOP | SSF47954 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
UniProt | A0A8I5ZM04_RAT | UniProtKB/TrEMBL |
A0A8I6A408 | ENTREZGENE, UniProtKB/TrEMBL | |
A0A8I6AP22_RAT | UniProtKB/TrEMBL | |
A6IIE2 | ENTREZGENE, UniProtKB/TrEMBL | |
A6IIE3 | ENTREZGENE, UniProtKB/TrEMBL | |
A6IIE4_RAT | UniProtKB/TrEMBL | |
A6IIE5_RAT | UniProtKB/TrEMBL | |
CCNC_RAT | UniProtKB/Swiss-Prot | |
G3V738 | ENTREZGENE, UniProtKB/TrEMBL | |
P39947 | ENTREZGENE |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2002-07-09 | Ccnc | cyclin C | Symbol and Name updated to reflect Human and Mouse nomenclature | 70877 | APPROVED |
Note Type | Note | Reference |
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gene_disease | human homolog is deleted in a subset of acute lymphoblastic leukemias | 728375 |