Gpd2 (glycerol-3-phosphate dehydrogenase 2) - Rat Genome Database

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Gene: Gpd2 (glycerol-3-phosphate dehydrogenase 2) Rattus norvegicus
Analyze
Symbol: Gpd2
Name: glycerol-3-phosphate dehydrogenase 2
RGD ID: 2726
Description: Enables glycerol-3-phosphate dehydrogenase [NAD(P)+] activity. Involved in NADH metabolic process and glycerol-3-phosphate metabolic process. Predicted to be part of glycerol-3-phosphate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human GPD2 (glycerol-3-phosphate dehydrogenase 2); PARTICIPATES IN D-glycericacidemia pathway; electron transport chain pathway; familial lipoprotein lipase deficiency pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Glycerol-3-phosophate dehydrogenase 2 (mitochondrial); glycerol-3-phosphate dehydrogenase 2, mitochondrial; glycerol-3-phosphate dehydrogenase, mitochondrial; GPD-M; GPDH-M; mtGPDH; mtGPDH gene, promoter region and alternative transcripts
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Cia11
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8362,209,432 - 62,346,590 (+)NCBIGRCr8
mRatBN7.2341,800,552 - 41,937,729 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl341,801,930 - 41,936,901 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx345,140,050 - 45,269,752 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0353,724,802 - 53,854,494 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0351,516,921 - 51,648,631 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0343,223,892 - 43,359,069 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl343,255,567 - 43,359,074 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0348,295,428 - 48,426,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4338,980,634 - 39,114,492 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1338,877,005 - 39,010,860 (+)NCBI
Celera339,895,025 - 40,025,154 (+)NCBICelera
Cytogenetic Map3q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(aminooxy)acetic acid  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5-triiodo-L-thyronine  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
corn oil  (EXP)
coumestrol  (ISO)
cyclosporin A  (ISO)
D-glucopyranose 6-phosphate  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
diarsenic trioxide  (ISO)
diazoxide  (ISO)
dichloroacetic acid  (ISO)
dihydroxyacetone  (ISO)
doxorubicin  (EXP)
enzyme inhibitor  (ISO)
ethanol  (EXP,ISO)
flavonoids  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
glucose  (ISO)
glycerol  (ISO)
glycerol 1-phosphate  (ISO)
hydrogen sulfide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
inulin  (ISO)
Iopodic acid  (EXP)
ivermectin  (ISO)
lead(0)  (ISO)
methotrexate  (ISO)
Muraglitazar  (EXP)
Nivalenol  (ISO)
ozone  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
potassium chloride  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
tamoxifen  (EXP)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetracycline  (ISO)
thapsigargin  (EXP,ISO)
thyroxine  (EXP)
topiramate  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
xylitol  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Sequence of rat mitochondrial glycerol-3-phosphate dehydrogenase cDNA. Evidence for EF-hand calcium-binding domains. Brown LJ, etal., J Biol Chem 1994 May 20;269(20):14363-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Identification of four new quantitative trait loci regulating arthritis severity and one new quantitative trait locus regulating autoantibody production in rats with collagen-induced arthritis. Griffiths MM, etal., Arthritis Rheum 2000 Jun;43(6):1278-89
5. Genetic mapping and chromosome localization of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene, a candidate for non-insulin-dependent diabetes mellitus. Koike G, etal., Genomics 1996 Nov 15;38(1):96-9.
6. Neuronal and astrocytic shuttle mechanisms for cytosolic-mitochondrial transfer of reducing equivalents: current evidence and pharmacological tools. McKenna MC, etal., Biochem Pharmacol. 2006 Feb 14;71(4):399-407. Epub 2005 Dec 20.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Cloning of a cDNA for the FAD-linked glycerol-3-phosphate dehydrogenase from rat liver and its regulation by thyroid hormones. Muller S and Seitz HJ, Proc Natl Acad Sci U S A 1994 Oct 25;91(22):10581-5.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. Online Mendelian Inheritance in Man, OMIM (TM). Online Mendelian Inheritance in Man, OMIM (TM).
12. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
13. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Role of NADH shuttles in glucose-induced insulin secretion from fetal beta-cells. Tan C, etal., Diabetes. 2002 Oct;51(10):2989-96.
18. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
19. NAD+/NADH and NADP+/NADPH in cellular functions and cell death: regulation and biological consequences. Ying W Antioxid Redox Signal. 2008 Feb;10(2):179-206.
Additional References at PubMed
PMID:12093800   PMID:12477932   PMID:12533437   PMID:12865426   PMID:14651853   PMID:15489334   PMID:17886033   PMID:17973206   PMID:18614015   PMID:21296886   PMID:23999537   PMID:25002582  
PMID:29476059  


Genomics

Comparative Map Data
Gpd2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8362,209,432 - 62,346,590 (+)NCBIGRCr8
mRatBN7.2341,800,552 - 41,937,729 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl341,801,930 - 41,936,901 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx345,140,050 - 45,269,752 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0353,724,802 - 53,854,494 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0351,516,921 - 51,648,631 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0343,223,892 - 43,359,069 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl343,255,567 - 43,359,074 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0348,295,428 - 48,426,568 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4338,980,634 - 39,114,492 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1338,877,005 - 39,010,860 (+)NCBI
Celera339,895,025 - 40,025,154 (+)NCBICelera
Cytogenetic Map3q21NCBI
GPD2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382156,400,281 - 156,586,403 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2156,435,290 - 156,613,735 (+)EnsemblGRCh38hg38GRCh38
GRCh372157,292,064 - 157,442,915 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362157,000,211 - 157,151,161 (+)NCBINCBI36Build 36hg18NCBI36
Build 342157,118,427 - 157,265,427NCBI
Celera2150,905,211 - 151,056,180 (+)NCBICelera
Cytogenetic Map2q24.1NCBI
HuRef2149,177,055 - 149,329,145 (+)NCBIHuRef
CHM1_12157,298,013 - 157,448,944 (+)NCBICHM1_1
T2T-CHM13v2.02156,852,575 - 157,039,187 (+)NCBIT2T-CHM13v2.0
Gpd2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39257,127,690 - 57,260,731 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl257,127,647 - 57,260,731 (+)EnsemblGRCm39 Ensembl
GRCm38257,237,678 - 57,370,719 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl257,237,635 - 57,370,719 (+)EnsemblGRCm38mm10GRCm38
MGSCv37257,090,089 - 57,223,130 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36257,053,683 - 57,182,998 (+)NCBIMGSCv36mm8
Celera258,979,703 - 59,113,189 (+)NCBICelera
Cytogenetic Map2C1.1NCBI
cM Map231.66NCBI
Gpd2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544916,695,435 - 16,802,908 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544916,695,855 - 16,804,184 (-)NCBIChiLan1.0ChiLan1.0
GPD2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21359,103,098 - 59,254,023 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B59,118,153 - 59,268,997 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B43,694,744 - 43,845,764 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B160,938,504 - 161,090,254 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B160,938,514 - 161,117,320 (+)Ensemblpanpan1.1panPan2
GPD2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1362,678,749 - 2,780,173 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl362,681,188 - 2,777,535 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha362,774,808 - 2,917,377 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0362,761,016 - 2,901,673 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl362,760,786 - 2,901,655 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1362,760,613 - 2,903,976 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0362,820,368 - 2,961,023 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0362,860,213 - 3,000,818 (+)NCBIUU_Cfam_GSD_1.0
Gpd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303119,785,975 - 119,930,842 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646921,705,421 - 21,831,745 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646921,705,421 - 21,833,143 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPD2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1563,619,762 - 63,728,633 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11563,592,723 - 63,728,636 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21570,841,147 - 70,946,575 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GPD2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11041,832,772 - 41,984,109 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1041,834,013 - 41,986,423 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040157,577,884 - 157,727,701 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpd2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247329,298,156 - 9,447,883 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gpd2
594 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:32
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000044419
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
10401810Kidm53Kidney mass QTL 53kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3822719447233430Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)31077870450302886Rat
70191BpQTLcluster4Blood pressure QTL cluster 43arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)31077870450302886Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)31086191289878372Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)314489145121056321Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)31500542276927699Rat
631676Cm8Cardiac mass QTL 87.030.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)31695470861954708Rat
731172Bp151Blood pressure QTL 1510.04arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31831145447233430Rat
12879849Bw180Body weight QTL 1800.037body mass (VT:0001259)body weight (CMO:0000012)31831145447233430Rat
12879850Cm91Cardiac mass QTL 910.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)31831145447233430Rat
12879851Cm92Cardiac mass QTL 920.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)31831145447233430Rat
12879852Cm93Cardiac mass QTL 930.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)31831145447233430Rat
12879853Am5Aortic mass QTL 50.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)31831145447233430Rat
12879854Kidm63Kidney mass QTL 630.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)31831145447233430Rat
10450804Scl70Serum cholesterol level QTL 704.70.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
10450794Scl69Serum cholesterol level QTL 696.30.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)32071409065714090Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)32749462144188411Rat
2313049Bss72Bone structure and strength QTL 722.60.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313076Bss74Bone structure and strength QTL 7420.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)32749462150302886Rat
2313079Bss73Bone structure and strength QTL 731.5tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)32749462150302886Rat
2313093Bmd77Bone mineral density QTL 772.20.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)32749462150302886Rat
2313101Bmd76Bone mineral density QTL 763.60.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)32749462150302886Rat
2302055Pia30Pristane induced arthritis QTL 303.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)32793691972936919Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)32824968773249687Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)32824968773249687Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)32824968773249687Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)32824968773249687Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)32824968773249687Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)32846857173468571Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)32846857173468571Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)329463235118376539Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)33035677398535386Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)33068464275684642Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)33068464275684642Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)331172320163586636Rat
11565451Bw177Body weight QTL 1770.002body mass (VT:0001259)body weight (CMO:0000012)33142640370668733Rat
11565452Kidm57Kidney mass QTL 570.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)33142640370668733Rat
12879866Cm94Cardiac mass QTL 940.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)33142640370668733Rat
12879867Cm95Cardiac mass QTL 950.047heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)33142640370668733Rat
12879868Am6Aortic mass QTL 60.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)33142640370668733Rat
2301400Cm68Cardiac mass QTL 680.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)33142640370668733Rat
1300169Bp177Blood pressure QTL 1772.96arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)33370334761017857Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)33370334778196190Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)333703347104104347Rat
10450852Stl33Serum triglyceride level QTL 333.40.05blood LDL triglyceride amount (VT:0010699)blood lipoprotein triglyceride level (CMO:0002685)33819223350749747Rat
10450816Scl75Serum cholesterol level QTL 754.40.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
10450813Scl74Serum cholesterol level QTL 745.80.001blood LDL cholesterol amount (VT:0000181)blood low density lipoprotein cholesterol level (CMO:0000053)33819223350749747Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)338192233133483320Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)33851780383517803Rat
4889975Bmd81Bone mineral density QTL 814.3tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)33871036550302886Rat
634317Bw117Body weight QTL 1173.58abdominal fat pad mass (VT:1000711)abdominal fat pad weight to body weight ratio (CMO:0000095)33945463753296578Rat
2302276Bw82Body weight QTL 824.32body mass (VT:0001259)body weight (CMO:0000012)33945463762951183Rat
1331777Bw24Body weight QTL 243.503body mass (VT:0001259)body weight (CMO:0000012)33945463789115240Rat
1331795Rf30Renal function QTL 303.708urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)33945463789115240Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)341874578104104347Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)341874578155617519Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)341874578155617519Rat

Markers in Region
D3Mgh21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,874,578 - 41,874,764 (+)MAPPERmRatBN7.2
Rnor_6.0343,295,930 - 43,296,111NCBIRnor6.0
Rnor_5.0348,366,676 - 48,366,857UniSTSRnor5.0
RGSC_v3.4339,052,757 - 39,052,938UniSTSRGSC3.4
RGSC_v3.4339,052,756 - 39,052,938RGDRGSC3.4
RGSC_v3.1338,949,128 - 38,949,310RGD
Celera339,965,027 - 39,965,201UniSTS
RH 3.4 Map3545.4RGD
RH 3.4 Map3545.4UniSTS
RH 2.0 Map3290.4RGD
SHRSP x BN Map328.1899RGD
FHH x ACI Map329.3899RGD
Cytogenetic Map3q21-q23UniSTS
D3Chm72  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,874,540 - 41,874,764 (+)MAPPERmRatBN7.2
Rnor_6.0343,295,892 - 43,296,111NCBIRnor6.0
Rnor_5.0348,366,638 - 48,366,857UniSTSRnor5.0
RGSC_v3.4339,052,718 - 39,052,938RGDRGSC3.4
RGSC_v3.4339,052,719 - 39,052,938UniSTSRGSC3.4
Celera339,964,989 - 39,965,201UniSTS
Cytogenetic Map3q21-q23UniSTS
D3Got256  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,852,989 - 41,853,127 (+)MAPPERmRatBN7.2
Rnor_6.0343,273,693 - 43,273,830NCBIRnor6.0
Rnor_5.0348,345,464 - 48,345,601UniSTSRnor5.0
RGSC_v3.4339,031,708 - 39,031,845UniSTSRGSC3.4
Celera339,945,177 - 39,945,308UniSTS
Cytogenetic Map3q21-q23UniSTS
BM385025  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,833,175 - 41,833,353 (+)MAPPERmRatBN7.2
Rnor_6.0343,253,979 - 43,254,156NCBIRnor6.0
Rnor_5.0348,325,480 - 48,325,657UniSTSRnor5.0
RGSC_v3.4339,010,972 - 39,011,149UniSTSRGSC3.4
Celera339,925,393 - 39,925,570UniSTS
RH 3.4 Map3549.9UniSTS
Cytogenetic Map3q21-q23UniSTS
RH142251  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,937,360 - 41,937,556 (+)MAPPERmRatBN7.2
Rnor_6.0343,358,703 - 43,358,898NCBIRnor6.0
Rnor_5.0348,429,411 - 48,429,606UniSTSRnor5.0
RGSC_v3.4339,117,335 - 39,117,530UniSTSRGSC3.4
Celera340,027,997 - 40,028,192UniSTS
RH 3.4 Map3543.5UniSTS
Cytogenetic Map3q21-q23UniSTS
BE109866  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2341,877,173 - 41,877,341 (+)MAPPERmRatBN7.2
Rnor_6.0343,298,521 - 43,298,688NCBIRnor6.0
Rnor_5.0348,369,267 - 48,369,434UniSTSRnor5.0
RGSC_v3.4339,055,348 - 39,055,515UniSTSRGSC3.4
Celera339,967,579 - 39,967,746UniSTS
RH 3.4 Map3544.1UniSTS
Cytogenetic Map3q21-q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 4 24 10 16 10 8 11 72 32 39 11 8
Low 39 33 31 3 31 2 3 2
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017591487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104330 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039104335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063283137 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF033035 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007135 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ495842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC083565 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473983 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223746 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U08027 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U43332 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X78593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000044419   ⟹   ENSRNOP00000043749
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl341,802,774 - 41,934,517 (+)Ensembl
Rnor_6.0 Ensembl343,255,567 - 43,355,732 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000088589   ⟹   ENSRNOP00000071823
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl341,832,160 - 41,934,517 (+)Ensembl
Rnor_6.0 Ensembl343,271,596 - 43,359,074 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000090323   ⟹   ENSRNOP00000071643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl341,872,448 - 41,934,517 (+)Ensembl
Rnor_6.0 Ensembl343,293,185 - 43,355,860 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000110582   ⟹   ENSRNOP00000082171
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl341,801,930 - 41,936,901 (+)Ensembl
RefSeq Acc Id: NM_012736   ⟹   NP_036868
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,211,653 - 62,343,383 (+)NCBI
mRatBN7.2341,802,774 - 41,934,517 (+)NCBI
Rnor_6.0343,223,927 - 43,355,860 (+)NCBI
Rnor_5.0348,295,428 - 48,426,568 (+)NCBI
RGSC_v3.4338,980,634 - 39,114,492 (+)RGD
Celera339,895,025 - 40,025,154 (+)RGD
Sequence:
RefSeq Acc Id: XM_039104329   ⟹   XP_038960257
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,241,010 - 62,346,590 (+)NCBI
mRatBN7.2341,832,127 - 41,937,727 (+)NCBI
RefSeq Acc Id: XM_039104330   ⟹   XP_038960258
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,240,994 - 62,346,590 (+)NCBI
mRatBN7.2341,832,113 - 41,937,727 (+)NCBI
RefSeq Acc Id: XM_039104331   ⟹   XP_038960259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,209,432 - 62,346,590 (+)NCBI
mRatBN7.2341,800,552 - 41,937,727 (+)NCBI
RefSeq Acc Id: XM_039104334   ⟹   XP_038960262
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,211,576 - 62,346,590 (+)NCBI
mRatBN7.2341,802,686 - 41,937,729 (+)NCBI
RefSeq Acc Id: XM_039104335   ⟹   XP_038960263
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,255,648 - 62,346,590 (+)NCBI
mRatBN7.2341,846,827 - 41,937,727 (+)NCBI
RefSeq Acc Id: XM_063283137   ⟹   XP_063139207
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8362,243,000 - 62,346,590 (+)NCBI
RefSeq Acc Id: NP_036868   ⟸   NM_012736
- Peptide Label: precursor
- UniProtKB: P35571 (UniProtKB/Swiss-Prot),   F1LNI0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000071643   ⟸   ENSRNOT00000090323
RefSeq Acc Id: ENSRNOP00000043749   ⟸   ENSRNOT00000044419
RefSeq Acc Id: ENSRNOP00000071823   ⟸   ENSRNOT00000088589
RefSeq Acc Id: XP_038960259   ⟸   XM_039104331
- Peptide Label: isoform X1
- UniProtKB: P35571 (UniProtKB/Swiss-Prot),   F1LNI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960262   ⟸   XM_039104334
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZUG1 (UniProtKB/TrEMBL),   F1LNI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960258   ⟸   XM_039104330
- Peptide Label: isoform X1
- UniProtKB: P35571 (UniProtKB/Swiss-Prot),   F1LNI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960257   ⟸   XM_039104329
- Peptide Label: isoform X1
- UniProtKB: P35571 (UniProtKB/Swiss-Prot),   F1LNI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038960263   ⟸   XM_039104335
- Peptide Label: isoform X3
- UniProtKB: A0A0G2K1F9 (UniProtKB/TrEMBL),   F1LNI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000082171   ⟸   ENSRNOT00000110582
RefSeq Acc Id: XP_063139207   ⟸   XM_063283137
- Peptide Label: isoform X1
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P35571-F1-model_v2 AlphaFold P35571 1-727 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2726 AgrOrtholog
BioCyc Gene G2FUF-49668 BioCyc
BioCyc Pathway PWY-6118 [glycerol-3-phosphate shuttle] BioCyc
  PWY-6952 [glycerophosphodiester degradation] BioCyc
BioCyc Pathway Image PWY-6118 BioCyc
  PWY-6952 BioCyc
Ensembl Genes ENSRNOG00000033824 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000044419 ENTREZGENE
  ENSRNOT00000044419.5 UniProtKB/TrEMBL
  ENSRNOT00000088589.2 UniProtKB/TrEMBL
  ENSRNOT00000090323.2 UniProtKB/TrEMBL
  ENSRNOT00000110582.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.8.870 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.50.50.60 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  D-Amino Acid Oxidase, subunit A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7134834 IMAGE-MGC_LOAD
InterPro DAO_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAO_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD-dep_OxRdtase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD/NAD-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G3P_DH_FAD-dep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93605 IMAGE-MGC_LOAD
NCBI Gene 25062 ENTREZGENE
PANTHER GLYCEROL-3-PHOSPHATE DEHYDROGENASE, MITOCHONDRIAL UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11985 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DAO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DAO_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gpd2 PhenoGen
PRINTS FADG3PDH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_G3PDH_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FAD_G3PDH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000033824 RatGTEx
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP FAD-linked reductases, C-terminal domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF51905 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC221205
UniProt A0A0G2K0Z7_RAT UniProtKB/TrEMBL
  A0A0G2K1F9 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZUG1 ENTREZGENE, UniProtKB/TrEMBL
  A6JF49_RAT UniProtKB/TrEMBL
  A6JF50_RAT UniProtKB/TrEMBL
  F1LNI0 ENTREZGENE, UniProtKB/TrEMBL
  GPDM_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-12 Gpd2  glycerol-3-phosphate dehydrogenase 2  Gpd2  glycerol-3-phosphate dehydrogenase 2, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Gpd2  glycerol-3-phosphate dehydrogenase 2, mitochondrial    glycerol-3-phosphate dehydrogenase 2   Name updated 1299863 APPROVED
2002-11-06 Gpd2  glycerol-3-phosphate dehydrogenase 2     Glycerol-3-phosophate dehydrogenase 2 (mitochondrial)  Name updated 625702 APPROVED
2002-06-10 Gpd2  Glycerol-3-phosophate dehydrogenase 2 (mitochondrial)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver, heart, muscle, brain, testis, and pancreas 632943
gene_expression expression in liver is induced by thryoid hormone 632943