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Gene: Aph1b (aph-1 homolog B, gamma secretase subunit) Rattus norvegicus
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Symbol: Aph1b
Name: aph-1 homolog B, gamma secretase subunit
Description: Predicted to have endopeptidase activity. Involved in locomotory behavior. Predicted to localize to the cytoplasm; gamma-secretase complex; and integral component of plasma membrane. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human APH1B (aph-1 homolog B, gamma-secretase subunit); PARTICIPATES IN Notch signaling pathway; syndecan signaling pathway; Alzheimer's disease pathway; INTERACTS WITH (RS)-amphetamine; 2,6-dinitrotoluene; 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: anterior pharynx defective 1 homolog B; anterior pharynx defective 1 homolog B (C. elegans); anterior pharynx defective 1b homolog; anterior pharynx defective 1b homolog (C. elegans); APH-1B'; APH1B gamma secretase subunit; gamma-secretase subunit APH-1B; presenilin stabilization factor-like; similar to anterior pharynx defective 1b homolog
Orthologs:
Homo sapiens (human) : APH1B (aph-1 homolog B, gamma-secretase subunit)  HGNC  Alliance
Mus musculus (house mouse) : Aph1b (aph1 homolog B, gamma secretase subunit)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Aph1b (aph-1 homolog B, gamma-secretase subunit)
Pan paniscus (bonobo/pygmy chimpanzee) : APH1B (aph-1 homolog B, gamma-secretase subunit)
Canis lupus familiaris (dog) : APH1B (aph-1 homolog B, gamma-secretase subunit)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Aph1b (aph-1 homolog B, gamma-secretase subunit)
Sus scrofa (pig) : APH1B (aph-1 homolog B, gamma-secretase subunit)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0872,508,008 - 72,598,921 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0876,942,439 - 76,963,484 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4871,122,681 - 71,143,726 (-)NCBIRGSC3.4rn4RGSC3.4
Celera874,251,130 - 74,264,693 (+)NCBICelera
Cytogenetic Map8q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
 
More on Aph1b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1562468
Created: 2006-02-09
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.