Ca5a (carbonic anhydrase 5A) - Rat Genome Database
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Gene: Ca5a (carbonic anhydrase 5A) Rattus norvegicus
Analyze
Symbol: Ca5a
Name: carbonic anhydrase 5A
RGD ID: 2243
Description: Exhibits carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Localizes to mitochondrion. Orthologous to human CA5A (carbonic anhydrase 5A); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CA-VA; Ca5; Car5a; carbonate dehydratase VA; carbonic anhydrase 5; carbonic anhydrase 5 mitochondrial; carbonic anhydrase 5, mitochondrial; carbonic anhydrase 5a, mitochondrial; carbonic anhydrase Va, mitochondrial; MGC108708
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21949,973,092 - 50,002,948 (-)NCBI
Rnor_6.0 Ensembl1954,731,859 - 54,761,670 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01954,731,829 - 54,761,697 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01965,451,126 - 65,480,815 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,158,607 - 52,188,664 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11952,163,493 - 52,193,545 (-)NCBI
Celera1949,218,046 - 49,247,995 (-)NCBICelera
Cytogenetic Map19q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrion  (IBA,IDA,ISO)

Molecular Function

References

Additional References at PubMed
PMID:7929150   PMID:10677517   PMID:12477932   PMID:14600151   PMID:14651853   PMID:15489334   PMID:18614015  


Genomics

Comparative Map Data
Ca5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21949,973,092 - 50,002,948 (-)NCBI
Rnor_6.0 Ensembl1954,731,859 - 54,761,670 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01954,731,829 - 54,761,697 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01965,451,126 - 65,480,815 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,158,607 - 52,188,664 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11952,163,493 - 52,193,545 (-)NCBI
Celera1949,218,046 - 49,247,995 (-)NCBICelera
Cytogenetic Map19q12NCBI
CA5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1687,881,546 - 87,936,580 (-)EnsemblGRCh38hg38GRCh38
GRCh381687,881,549 - 87,936,575 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371687,915,155 - 87,970,135 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh371687,921,625 - 87,970,173 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361686,479,126 - 86,527,613 (-)NCBINCBI36hg18NCBI36
Build 341686,479,125 - 86,527,613NCBI
Celera1672,219,173 - 72,267,375 (-)NCBI
Cytogenetic Map16q24.2NCBI
HuRef1673,662,132 - 73,710,650 (-)NCBIHuRef
CHM1_11689,333,043 - 89,381,480 (-)NCBICHM1_1
Car5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398122,642,874 - 122,671,651 (-)NCBIGRCm39mm39
GRCm388121,916,135 - 121,944,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,916,126 - 121,944,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv378124,440,035 - 124,468,812 (-)NCBIGRCm37mm9NCBIm37
MGSCv368121,987,915 - 122,017,051 (-)NCBImm8
MGSCv368124,802,236 - 124,830,994 (-)NCBImm8
Celera8126,138,230 - 126,172,629 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.81NCBI
Ca5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,139,920 - 2,160,597 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555412,141,450 - 2,159,955 (-)NCBIChiLan1.0ChiLan1.0
CA5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11687,887,288 - 87,903,159 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01668,564,400 - 68,618,614 (-)NCBIMhudiblu_PPA_v0panPan3
CA5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl565,269,635 - 65,296,777 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1565,269,855 - 65,297,593 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ca5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366411,478,285 - 1,495,490 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,505,566 - 1,538,494 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.161,495,615 - 1,539,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CA5A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1573,284,536 - 73,333,629 (-)NCBI
Ca5a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247461,293,619 - 1,323,067 (+)NCBI

Position Markers
D19Rat21  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01954,735,217 - 54,735,354NCBIRnor6.0
Rnor_5.01965,454,505 - 65,454,642UniSTSRnor5.0
RGSC_v3.41952,161,990 - 52,162,128RGDRGSC3.4
RGSC_v3.41952,161,991 - 52,162,128UniSTSRGSC3.4
RGSC_v3.11952,166,872 - 52,167,009RGD
Celera1949,221,436 - 49,221,573UniSTS
RH 3.4 Map19682.9RGD
RH 3.4 Map19682.9UniSTS
RH 2.0 Map19661.4RGD
Cytogenetic Map19q12UniSTS
AU048492  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01954,754,723 - 54,754,842NCBIRnor6.0
Rnor_5.01965,474,033 - 65,474,152UniSTSRnor5.0
RGSC_v3.41952,181,788 - 52,181,907UniSTSRGSC3.4
Celera1949,241,081 - 49,241,200UniSTS
Cytogenetic Map19q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19243296362275575Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19650676160220581Rat
1578764Stresp19Stress response QTL 193.60.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)191899398262275575Rat
7411549Bw130Body weight QTL 13050.001body mass (VT:0001259)body weight gain (CMO:0000420)191917749562275575Rat
2298478Eau8Experimental allergic uveoretinitis QTL 80.0163uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)192140778762275575Rat
61350Bp32Blood pressure QTL 320.012arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)192481825762275575Rat
724546Kidm3Kidney mass QTL 33.1kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)193299439262275575Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum insulin level (CMO:0000358)193791679960220451Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)193791679960220451Rat
5135224Leukc1Leukocyte quantity QTL 1eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)194883071260220581Rat
2313395Anxrr26Anxiety related response QTL 26aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)195473521758072143Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:49
Count of miRNA genes:39
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000025848
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 23 23 23
Low 3 8 30 14 19 14 8 8 11 11 16 11 8
Below cutoff 16 4 4 4 2 58 22 24

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000025848   ⟹   ENSRNOP00000025848
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1954,731,859 - 54,761,670 (-)Ensembl
RefSeq Acc Id: NM_019293   ⟹   NP_062166
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21949,973,092 - 50,002,906 (-)NCBI
Rnor_6.01954,731,829 - 54,761,637 (-)NCBI
Rnor_5.01965,451,126 - 65,480,815 (-)NCBI
RGSC_v3.41952,158,607 - 52,188,664 (-)RGD
Celera1949,218,046 - 49,247,995 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255782   ⟹   XP_006255844
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01954,731,962 - 54,761,697 (-)NCBI
Rnor_5.01965,451,126 - 65,480,815 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097955   ⟹   XP_038953883
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21949,989,115 - 50,002,948 (-)NCBI
Protein Sequences
Protein RefSeqs NP_062166 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953883 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA50832 (Get FASTA)   NCBI Sequence Viewer  
  AAH88147 (Get FASTA)   NCBI Sequence Viewer  
  EDL92734 (Get FASTA)   NCBI Sequence Viewer  
  P43165 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062166   ⟸   NM_019293
- Peptide Label: precursor
- UniProtKB: P43165 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006255844   ⟸   XM_006255782
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000025848   ⟸   ENSRNOT00000025848
RefSeq Acc Id: XP_038953883   ⟸   XM_039097955
- Peptide Label: isoform X1
Protein Domains
Alpha-carbonic anhydrase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701202
Promoter ID:EPDNEW_R11724
Type:multiple initiation site
Name:Ca5a_1
Description:carbonic anhydrase 5A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01954,761,641 - 54,761,701EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2243 AgrOrtholog
Ensembl Genes ENSRNOG00000019098 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000025848 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000025848 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7323596 IMAGE-MGC_LOAD
InterPro CA_dom UniProtKB/Swiss-Prot
  CA_dom_sf UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot
KEGG Report rno:54233 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108708 IMAGE-MGC_LOAD
NCBI Gene 54233 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot
Pfam Carb_anhydrase UniProtKB/Swiss-Prot
PhenoGen Ca5a PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot
  ALPHA_CA_2 UniProtKB/Swiss-Prot
SMART Carb_anhydrase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot
UniProt CAH5A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-16 Ca5a  carbonic anhydrase 5A  Car5a  carbonic anhydrase 5A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2018-03-16 Car5a  carbonic anhydrase 5A  Ca5a  carbonic anhydrase 5A  Symbol changed 629549 APPROVED
2016-05-20 Ca5a  carbonic anhydrase 5A  Car5a  carbonic anhydrase 5A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-05-18 Car5a  carbonic anhydrase 5A  Car5a  carbonic anhydrase 5a, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-20 Car5a  carbonic anhydrase 5a, mitochondrial  Ca5a  carbonic anhydrase Va, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-05-15 Ca5a  carbonic anhydrase Va, mitochondrial  Ca5a  carbonic anhydrase 5a, mitochondrial  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Ca5a  carbonic anhydrase 5a, mitochondrial    carbonic anhydrase 5  Name updated 1299863 APPROVED
2002-06-10 Ca5a  carbonic anhydrase 5      Name updated 70584 APPROVED
2001-12-10 Ca5a  carbonic anhydrase 5, mitochondrial      Symbol and Name updated to reflect Human and Mouse nomenclature 69665 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to mitochondria 69789
gene_process may be involved in gluconeogenesis and ureagenesis 69789