Car5a (carbonic anhydrase 5A) - Rat Genome Database

Name: Car5a
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Car5a (carbonic anhydrase 5A) Rattus norvegicus

Analyze

Symbol:

Car5a

Name:

carbonic anhydrase 5A

RGD ID:

2243

Description:

Enables carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Predicted to act upstream of with a positive effect on tricarboxylic acid cycle and urea cycle. Located in mitochondrion. Orthologous to human CA5A (carbonic anhydrase 5A); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

CA-VA; Ca5; Ca5a; carbonate dehydratase VA; carbonic anhydrase 5; carbonic anhydrase 5 mitochondrial; carbonic anhydrase 5, mitochondrial; carbonic anhydrase 5a, mitochondrial; carbonic anhydrase Va, mitochondrial; MGC108708

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	CA5A (carbonic anhydrase 5A)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Car5a (carbonic anhydrase 5a, mitochondrial)	HGNC	Panther
Chinchilla lanigera (long-tailed chinchilla):	Ca5a (carbonic anhydrase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	CA5A (carbonic anhydrase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	CA5A (carbonic anhydrase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ca5a (carbonic anhydrase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	CA5A (carbonic anhydrase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	CA5A (carbonic anhydrase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ca5a (carbonic anhydrase 5A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CA5B (carbonic anhydrase 5B)	HGNC	OrthoDB
Alliance orthologs ³
Mus musculus (house mouse):	Car5a (carbonic anhydrase 5a, mitochondrial)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	CA5A (carbonic anhydrase 5A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	ca5a (carbonic anhydrase Va)	Alliance	DIOPT (Hieranoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	CAH1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	cah-4	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Drosophila melanogaster (fruit fly):	CAH2	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Drosophila melanogaster (fruit fly):	CAH3	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	49,973,092 - 50,002,948 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	19	49,973,107 - 50,002,906 (-)	Ensembl
Rnor_6.0	19	54,731,829 - 54,761,697 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	54,731,859 - 54,761,670 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	65,451,126 - 65,480,815 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	52,158,607 - 52,188,664 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	19	52,163,493 - 52,193,545 (-)	NCBI
Celera	19	49,218,046 - 49,247,995 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

16Q24.3 Microdeletion Syndrome (ISO)

CARBONIC ANHYDRASE VA DEFICIENCY, HYPERAMMONEMIA DUE TO (ISO)

Experimental Liver Cirrhosis (ISO)

mucopolysaccharidosis IVA (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2,4,6-trinitrotoluene (EXP)

2,4-dinitrotoluene (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acetazolamide (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP)

buspirone (EXP)

butanal (ISO)

C60 fullerene (EXP)

carbon nanotube (ISO)

carbonates (ISO)

chloric acid (ISO)

chlorpyrifos (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

fumonisin B1 (ISO)

furan (EXP)

gentamycin (EXP)

glafenine (EXP)

methapyrilene (ISO)

molybdate (ISO)

N-nitrosodiethylamine (EXP,ISO)

N-nitrosodimethylamine (EXP)

nitric acid (ISO)

oryzalin (ISO)

paracetamol (ISO)

perchlorate (ISO)

phenformin (EXP)

phenobarbital (ISO)

pirinixic acid (EXP,ISO)

propiconazole (ISO)

rotenone (EXP)

sodium arsenite (ISO)

sodium dichromate (EXP)

sulfamic acid (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

titanium dioxide (EXP)

tungstate (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vancomycin (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

one-carbon metabolic process (IBA)

Cellular Component

cytoplasm (IBA)

mitochondrion (IBA,IDA,ISO)

Molecular Function

carbonate dehydratase activity (IBA,IDA,ISO)

hydro-lyase activity (IBA)

zinc ion binding (IEA)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG
3.	MGD data from the GO Consortium
4.	Nagao Y, etal., Proc Natl Acad Sci U S A 1994 Oct 25;91(22):10330-4.
5.	OMIM Disease Annotation Pipeline
6.	RGD automated data pipeline
7.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:7929150	PMID:10677517	PMID:12477932	PMID:14600151	PMID:14651853	PMID:15489334	PMID:18614015

Genomics

Comparative Map Data

Car5a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	19	49,973,092 - 50,002,948 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	19	49,973,107 - 50,002,906 (-)	Ensembl
Rnor_6.0	19	54,731,829 - 54,761,697 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	54,731,859 - 54,761,670 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	65,451,126 - 65,480,815 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	52,158,607 - 52,188,664 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	19	52,163,493 - 52,193,545 (-)	NCBI
Celera	19	49,218,046 - 49,247,995 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

CA5A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	87,881,549 - 87,936,529 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	16	87,881,546 - 87,936,580 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	87,915,155 - 87,970,135 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	86,479,126 - 86,527,613 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	16	86,479,125 - 86,527,613	NCBI
Celera	16	72,219,173 - 72,267,375 (-)	NCBI
Cytogenetic Map	16	q24.2	NCBI
HuRef	16	73,662,132 - 73,710,650 (-)	NCBI		HuRef
CHM1_1	16	89,333,043 - 89,381,480 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	93,954,203 - 94,009,111 (-)	NCBI

Car5a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	122,642,874 - 122,671,651 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	8	122,642,865 - 122,671,643 (-)	Ensembl
GRCm38	8	121,916,135 - 121,944,912 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	121,916,126 - 121,944,904 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	124,440,035 - 124,468,812 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	121,987,915 - 122,017,051 (-)	NCBI			mm8
MGSCv36	8	124,802,236 - 124,830,994 (-)	NCBI			mm8
Celera	8	126,138,230 - 126,172,629 (-)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	70.81	NCBI

Ca5a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	2,139,920 - 2,160,597 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955541	2,141,450 - 2,159,955 (-)	NCBI	ChiLan1.0	ChiLan1.0

CA5A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	16	87,887,288 - 87,903,159 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	16	68,564,400 - 68,618,614 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

CA5A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	65,269,855 - 65,297,593 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	65,269,635 - 65,296,777 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	65,280,118 - 65,307,768 (+)	NCBI
ROS_Cfam_1.0	5	65,489,652 - 65,517,389 (+)	NCBI
ROS_Cfam_1.0 Ensembl	5	65,489,538 - 65,516,573 (+)	Ensembl
UMICH_Zoey_3.1	5	65,515,185 - 65,542,854 (+)	NCBI
UNSW_CanFamBas_1.0	5	65,346,901 - 65,374,559 (+)	NCBI
UU_Cfam_GSD_1.0	5	65,753,935 - 65,781,642 (+)	NCBI

Ca5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	25,719,672 - 25,742,042 (+)	NCBI
SpeTri2.0	NW_004936641	1,478,285 - 1,495,490 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CA5A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	1,505,566 - 1,538,494 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	1,495,615 - 1,539,390 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

CA5A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	73,284,536 - 73,333,629 (-)	NCBI	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666047	2,374,418 - 2,429,386 (+)	NCBI	Vero_WHO_p1.0

Ca5a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	1,293,875 - 1,315,890 (+)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624746	1,293,619 - 1,323,067 (+)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

D19Rat21

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	49,976,481 - 49,976,619 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	54,735,217 - 54,735,354	NCBI	Rnor6.0
Rnor_5.0	19	65,454,505 - 65,454,642	UniSTS	Rnor5.0
RGSC_v3.4	19	52,161,990 - 52,162,128	RGD	RGSC3.4
RGSC_v3.4	19	52,161,991 - 52,162,128	UniSTS	RGSC3.4
RGSC_v3.1	19	52,166,872 - 52,167,009	RGD
Celera	19	49,221,436 - 49,221,573	UniSTS
RH 3.4 Map	19	682.9	UniSTS
RH 3.4 Map	19	682.9	RGD
RH 2.0 Map	19	661.4	RGD
Cytogenetic Map	19	q12	UniSTS

AU048492

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	49,995,987 - 49,996,107 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	54,754,723 - 54,754,842	NCBI	Rnor6.0
Rnor_5.0	19	65,474,033 - 65,474,152	UniSTS	Rnor5.0
RGSC_v3.4	19	52,181,788 - 52,181,907	UniSTS	RGSC3.4
Celera	19	49,241,081 - 49,241,200	UniSTS
Cytogenetic Map	19	q12	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2187927	56457239	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	4096155	55283277	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	15455860	57337602	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	15630201	57337602	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	17154433	57337602	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	20483575	57337602	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	29322490	57337602	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	19	33838214	55283146	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	33838214	55283146	Rat
5135224	Leukc1	Leukocyte quantity QTL 1			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	19	44340214	55283277	Rat
2313395	Anxrr26	Anxiety related response QTL 26			aggression-related behavior trait (VT:0015014)	tameness/aggressiveness composite score (CMO:0002136)	19	49976481	53225766	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	49
Count of miRNA genes:	39
Interacting mature miRNAs:	47
Transcripts:	ENSRNOT00000025848
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium			23	23		23
Low	3	8	30	14	19	14	8	8	11	11	16	11	8
Below cutoff		16	4	4		4		2	58	22	24

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019293	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006255782	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039097955	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC109048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC088147	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000313	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U12268	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000025848 ⟹ ENSRNOP00000025848

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	19	49,973,107 - 50,002,906 (-)	Ensembl
Rnor_6.0 Ensembl	19	54,731,859 - 54,761,670 (-)	Ensembl

RefSeq Acc Id:

NM_019293 ⟹ NP_062166

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	49,973,092 - 50,002,906 (-)	NCBI
Rnor_6.0	19	54,731,829 - 54,761,637 (-)	NCBI
Rnor_5.0	19	65,451,126 - 65,480,815 (-)	NCBI
RGSC_v3.4	19	52,158,607 - 52,188,664 (-)	RGD
Celera	19	49,218,046 - 49,247,995 (-)	NCBI

Sequence:

show sequence

TCCGAGGTGGCCCTGACCAAAACAAGGGCAGACAGTGGGCCACCACCCCGCCATGCTCAGAGCC
AAGATGCTCGGGAGAGGCCCCTACAAGCCCTTAGCCATCCTCAGGCACATGGGACCTCTCTGTG
CCACAAGGCCACAGCACTGGCGCTTCCAGCATTCCTACGCAGAGAAACACAGCAACTGTGCCCG
GCACCCTCTCTGGACTGGCCCAGTGTCCTCACCGGGAGGCACCCAGCAGTCTCCCATTAATATC
CAGTGGACGGATAGTGTCTATGACCCGAAGCTGGCACCGCTCAGGGTCTCCTATGATGCTGCGT
CCTGCAGATACCTCTGGAACACTGGTTACTTCTTCCAGGTGGAGTTTGACGATTCCTGTGAGGA
GTCAGGGATCAGTGGTGGGCCTCTGGGAAACCACTACAGGCTGAAGCAGTTTCACTTCCACTGG
GGAGCAACAGATGAATGGGGCTCTGAGCACATGGTGGACGGCCATGCCTACCCGGCTGAGCTCC
ATTTGGTTCACTGGAATTCCATGAAATATGAAAATTACAAGAAAGCCACCACGGGGGAGAATGG
ACTGGCGGTGATTGGAGTGTTTCTGAAGCTCGGGGCCCATCACGAGGCCCTGCAGAGGCTGGTG
GACATCTTGCCGGAAGTAAGACACAAGGACACACAGGTGACCATGGGGCCCTTTGACCCTTCTT
GCCTGCTGCCTGCCTGCCGGGATTACTGGACCTACCCTGGCTCCCTCACCACCCCACCACTGGC
TGAGTCAGTCACCTGGATTGTGCACAAGATGCCCATTGAGGTGTCCCCGAGCCAGCTGTCCACA
TTCCGTACACTCTTGTTCTCCGGGCGAGGTGAGGACGAGGAGGTGATGGTGAACAACTTCCGCC
CGCTCCAACCACTCAGGGGCCGCAACGTTCGCTCCTCCTTCCAGGTCCCCAGGGTGGGAACAAA
GTCTTGATCTCAGGATGAGGTCTGTAAGGATAGGCAGAGCGGATGGAAAAGGGGGTGCGCATTT
CCAGGGTGCGACGCCTGGATTAAAAAAAAAATGGCTGCAGAGATGGCTCAGGGGTTAAGAGCAC
TGACTGCTCTTCCAGAGGTCCTGAGTTCAGTTCCCAGTAACCACATGGTGGCTCACAACCATCT
GTAATGGGATCCGATGCCCTCTTCTGGTGTGTCTGAAGAGAGCGACACTGCACTCATATGCATT
AAATTAATAAATCTTTAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039097955 ⟹ XP_038953883

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	19	49,989,115 - 50,002,948 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_062166	(Get FASTA)	NCBI Sequence Viewer
	XP_038953883	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA50832	(Get FASTA)	NCBI Sequence Viewer
	AAH88147	(Get FASTA)	NCBI Sequence Viewer
	EDL92734	(Get FASTA)	NCBI Sequence Viewer
	P43165	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_062166 ⟸ NM_019293
- Peptide Label:	precursor
- UniProtKB:	P43165 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLRAKMLGRGPYKPLAILRHMGPLCATRPQHWRFQHSYAEKHSNCARHPLWTGPVSSPGGTQQS PINIQWTDSVYDPKLAPLRVSYDAASCRYLWNTGYFFQVEFDDSCEESGISGGPLGNHYRLKQF HFHWGATDEWGSEHMVDGHAYPAELHLVHWNSMKYENYKKATTGENGLAVIGVFLKLGAHHEAL QRLVDILPEVRHKDTQVTMGPFDPSCLLPACRDYWTYPGSLTTPPLAESVTWIVHKMPIEVSPS QLSTFRTLLFSGRGEDEEVMVNNFRPLQPLRGRNVRSSFQVPRVGTKS hide sequence

RefSeq Acc Id:

ENSRNOP00000025848 ⟸ ENSRNOT00000025848

RefSeq Acc Id:	XP_038953883 ⟸ XM_039097955
- Peptide Label:	isoform X1

Protein Domains

Alpha-carbonic anhydrase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P43165-F1-model_v2	AlphaFold	P43165	1-304	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701202

Promoter ID:

EPDNEW_R11724

Type:

multiple initiation site

Name:

Ca5a_1

Description:

carbonic anhydrase 5A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	54,761,641 - 54,761,701	EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)

ACI/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2243	AgrOrtholog
BioCyc Gene	G2FUF-5409	BioCyc
Ensembl Genes	ENSRNOG00000019098	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000025848	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000025848	ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH	3.10.200.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7323596	IMAGE-MGC_LOAD
InterPro	CA_dom	UniProtKB/Swiss-Prot
	CA_dom_sf	UniProtKB/Swiss-Prot
	Carbonic_anhydrase_a-class	UniProtKB/Swiss-Prot
	Carbonic_anhydrase_a-class_CS	UniProtKB/Swiss-Prot
KEGG Report	rno:54233	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:108708	IMAGE-MGC_LOAD
NCBI Gene	54233	ENTREZGENE
PANTHER	PTHR18952	UniProtKB/Swiss-Prot
Pfam	Carb_anhydrase	UniProtKB/Swiss-Prot
PhenoGen	Car5a	PhenoGen
PROSITE	ALPHA_CA_1	UniProtKB/Swiss-Prot
	ALPHA_CA_2	UniProtKB/Swiss-Prot
SMART	Carb_anhydrase	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF51069	UniProtKB/Swiss-Prot
UniProt	CAH5A_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2022-04-18	Car5a	carbonic anhydrase 5A	Ca5a	carbonic anhydrase 5A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2019-04-16	Ca5a	carbonic anhydrase 5A	Car5a	carbonic anhydrase 5A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2018-03-16	Car5a	carbonic anhydrase 5A	Ca5a	carbonic anhydrase 5A	Symbol changed	629549	APPROVED
2016-05-20	Ca5a	carbonic anhydrase 5A	Car5a	carbonic anhydrase 5A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-05-18	Car5a	carbonic anhydrase 5A	Car5a	carbonic anhydrase 5a, mitochondrial	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-20	Car5a	carbonic anhydrase 5a, mitochondrial	Ca5a	carbonic anhydrase Va, mitochondrial	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-05-15	Ca5a	carbonic anhydrase Va, mitochondrial	Ca5a	carbonic anhydrase 5a, mitochondrial	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Ca5a	carbonic anhydrase 5a, mitochondrial		carbonic anhydrase 5	Name updated	1299863	APPROVED
2002-06-10	Ca5a	carbonic anhydrase 5			Name updated	70584	APPROVED
2001-12-10	Ca5a	carbonic anhydrase 5, mitochondrial			Symbol and Name updated to reflect Human and Mouse nomenclature	69665	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_cellular_localization	localized to mitochondria	69789
gene_process	may be involved in gluconeogenesis and ureagenesis	69789

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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