Car5a (carbonic anhydrase 5a, mitochondrial) - Rat Genome Database

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Gene: Car5a (carbonic anhydrase 5a, mitochondrial) Mus musculus
Analyze
Symbol: Car5a
Name: carbonic anhydrase 5a, mitochondrial
RGD ID: 731919
MGI Page MGI
Description: Exhibits carbonate dehydratase activity. Predicted to be involved in one-carbon metabolic process. Localizes to mitochondrion. Orthologous to human CA5A (carbonic anhydrase 5A); INTERACTS WITH 1,1-dichloroethene; 3,3',4,4'-tetrachlorobiphenyl; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Ca; CA Y; CA-VA; Ca5a; Car5; carbonate dehydratase VA; carbonic anhydrase 5, mitochondrial; carbonic anhydrase 5b, mitochondrial; carbonic anhydrase VA; CAV
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398122,642,874 - 122,671,651 (-)NCBIGRCm39mm39
GRCm39 Ensembl8122,642,865 - 122,671,643 (-)Ensembl
GRCm388121,916,135 - 121,944,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,916,126 - 121,944,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv378124,440,035 - 124,468,812 (-)NCBIGRCm37mm9NCBIm37
MGSCv368121,987,915 - 122,017,051 (-)NCBImm8
MGSCv368124,802,236 - 124,830,994 (-)NCBImm8
Celera8126,138,230 - 126,172,629 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
mitochondrion  (HDA,IBA,IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:2109313   PMID:7479916   PMID:7929150   PMID:9069129   PMID:9882455   PMID:10677517   PMID:11851394   PMID:12477932   PMID:14600151   PMID:14610273   PMID:14681479   PMID:15489334  
PMID:17362527   PMID:17626619   PMID:18614015   PMID:18799693   PMID:21873635   PMID:22109883   PMID:23233153   PMID:23589845   PMID:28131914   PMID:29768498  


Genomics

Comparative Map Data
Car5a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm398122,642,874 - 122,671,651 (-)NCBIGRCm39mm39
GRCm39 Ensembl8122,642,865 - 122,671,643 (-)Ensembl
GRCm388121,916,135 - 121,944,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl8121,916,126 - 121,944,904 (-)EnsemblGRCm38mm10GRCm38
MGSCv378124,440,035 - 124,468,812 (-)NCBIGRCm37mm9NCBIm37
MGSCv368121,987,915 - 122,017,051 (-)NCBImm8
MGSCv368124,802,236 - 124,830,994 (-)NCBImm8
Celera8126,138,230 - 126,172,629 (-)NCBICelera
Cytogenetic Map8E1NCBI
cM Map870.81NCBI
CA5A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1687,881,546 - 87,936,580 (-)EnsemblGRCh38hg38GRCh38
GRCh381687,881,549 - 87,936,575 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371687,915,155 - 87,970,135 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361686,479,126 - 86,527,613 (-)NCBINCBI36hg18NCBI36
Build 341686,479,125 - 86,527,613NCBI
Celera1672,219,173 - 72,267,375 (-)NCBI
Cytogenetic Map16q24.2NCBI
HuRef1673,662,132 - 73,710,650 (-)NCBIHuRef
CHM1_11689,333,043 - 89,381,480 (-)NCBICHM1_1
Ca5a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21949,973,092 - 50,002,948 (-)NCBI
Rnor_6.0 Ensembl1954,731,859 - 54,761,670 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01954,731,829 - 54,761,697 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01965,451,126 - 65,480,815 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41952,158,607 - 52,188,664 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11952,163,493 - 52,193,545 (-)NCBI
Celera1949,218,046 - 49,247,995 (-)NCBICelera
Cytogenetic Map19q12NCBI
Ca5a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555412,139,920 - 2,160,597 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555412,141,450 - 2,159,955 (-)NCBIChiLan1.0ChiLan1.0
CA5A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11687,887,288 - 87,903,159 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v01668,564,400 - 68,618,614 (-)NCBIMhudiblu_PPA_v0panPan3
CA5A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1565,269,855 - 65,297,593 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl565,269,635 - 65,296,777 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha565,280,118 - 65,307,768 (+)NCBI
ROS_Cfam_1.0565,489,652 - 65,517,389 (+)NCBI
UMICH_Zoey_3.1565,515,185 - 65,542,854 (+)NCBI
UNSW_CanFamBas_1.0565,346,901 - 65,374,559 (+)NCBI
UU_Cfam_GSD_1.0565,753,935 - 65,781,642 (+)NCBI
Ca5a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934925,719,672 - 25,742,042 (+)NCBI
SpeTri2.0NW_0049366411,478,285 - 1,495,490 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA5A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl61,505,566 - 1,538,494 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.161,495,615 - 1,539,390 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
CA5A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1573,284,536 - 73,333,629 (-)NCBI
Ca5a
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247461,293,619 - 1,323,067 (+)NCBI

Position Markers
Car5a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv378124,440,057 - 124,440,259UniSTSGRCm37
Celera8126,138,252 - 126,138,454UniSTS
Cytogenetic Map8E1UniSTS
cM Map867.0UniSTS
cM Map865.0UniSTS
cM Map867.0UniSTS
Car5a  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm388121,916,157 - 121,916,359UniSTSGRCm38
MGSCv378124,440,057 - 124,440,259UniSTSGRCm37
Celera8126,138,252 - 126,138,454UniSTS
Cytogenetic Map8E1UniSTS
cM Map867.0UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
27095912Pglq14_mpelvic girdle length QTL 14, 16 week (mouse)873400000126100000Mouse
27226796Scvln16_msacral vertebrae length 2, 16 week (mouse)889000000130800000Mouse
1357494Obsty2_mobesity 2 (mouse)Not determined895518613129018580Mouse
12880431Fgf23lq2_mFGF23 serum level QTL 2 (mouse)896900000129401213Mouse
11252141Fdr2_mfat response to dietary restriction 2 (mouse)897663894129401213Mouse
1301481Lith11_mlithogenic gene 11 (mouse)Not determined897836895129401213Mouse
1301080Sluc9_msusceptibility to lung cancer 9 (mouse)Not determined899101792129401213Mouse
1302105Im1_mImmunoregulatory 1 (mouse)Not determined899101792129401213Mouse
4141435Fbtq3_mfemoral bone trait QTL 3 (mouse)Not determined8100238570129401213Mouse
1301316Dntcs1_mdental caries susceptibility 1 (mouse)Not determined8102716921127055036Mouse
11532691Sluc38_msusceptibility to lung cancer 38 (mouse)8104307238129401213Mouse
11532692Sluc38a_msusceptibility to lung cancer 38a (mouse)8104307238129401213Mouse
14746994Manh65_mmandible shape 65 (mouse)8105762890129401213Mouse
10412273Fcd1_mfunctional capillary density 1 (mouse)Not determined8109688333129401213Mouse
10412274Leci1_mleukocyte endothelial cell interactions 1 (mouse)Not determined8109688333129401213Mouse
12904938Edlmmq7_mextensor digitorum longus muscle mass QTL 7 (mouse)8110755016129401213Mouse
12904960Gmmq6_mgastrocnemius muscle mass QTL 6 (mouse)8110755016129401213Mouse
4141546Mrdq3_mmodifier of retinal degeneration QTL 3 (mouse)Not determined113712788125329141Mouse
26884375Skwq2_mskull length QTL 2, 5 week (mouse)8120000000131200000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:398
Count of miRNA genes:311
Interacting mature miRNAs:346
Transcripts:ENSMUST00000057653, ENSMUST00000151462
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000057653   ⟹   ENSMUSP00000060457
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8121,916,126 - 121,944,904 (-)Ensembl
RefSeq Acc Id: ENSMUST00000151462
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl8121,918,054 - 121,927,474 (-)Ensembl
RefSeq Acc Id: NM_007608   ⟹   NP_031634
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm398122,642,874 - 122,671,651 (-)NCBI
GRCm388121,916,135 - 121,944,912 (-)ENTREZGENE
MGSCv378124,440,035 - 124,468,812 (-)RGD
Celera8126,138,230 - 126,172,629 (-)RGD
cM Map8 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_031634 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH30174 (Get FASTA)   NCBI Sequence Viewer  
  CAA36233 (Get FASTA)   NCBI Sequence Viewer  
  EDL11669 (Get FASTA)   NCBI Sequence Viewer  
  P23589 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_031634   ⟸   NM_007608
- Peptide Label: precursor
- UniProtKB: P23589 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000060457   ⟸   ENSMUST00000057653
Protein Domains
Alpha-carbonic anhydrase

Promoters
RGD ID:8668499
Promoter ID:EPDNEW_M12281
Type:initiation region
Name:Car5a_1
Description:Mus musculus carbonic anhydrase 5a, mitochondrial , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm388121,944,863 - 121,944,923EPDNEW
RGD ID:6842882
Promoter ID:MM_KWN:55980
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000076969
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368124,451,271 - 124,452,372 (-)MPROMDB
RGD ID:6842880
Promoter ID:MM_KWN:55981
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Liver
Transcripts:OTTMUST00000076968
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv368124,468,521 - 124,469,021 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:101946 AgrOrtholog
Ensembl Genes ENSMUSG00000025317 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000060457 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000057653 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot
InterPro CA_dom UniProtKB/Swiss-Prot
  CA_dom_sf UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot
KEGG Report mmu:12352 UniProtKB/Swiss-Prot
MGD MGI:101946 ENTREZGENE
NCBI Gene 12352 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot
Pfam Carb_anhydrase UniProtKB/Swiss-Prot
PhenoGen Car5a PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot
  ALPHA_CA_2 UniProtKB/Swiss-Prot
SMART Carb_anhydrase UniProtKB/Swiss-Prot
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot
UniProt CAH5A_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE