Tmem30b (transmembrane protein 30B) - Rat Genome Database

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Gene: Tmem30b (transmembrane protein 30B) Rattus norvegicus
Analyze
Symbol: Tmem30b
Name: transmembrane protein 30B
RGD ID: 1308732
Description: Predicted to enable aminophospholipid flippase activity. Predicted to be involved in aminophospholipid transport; phospholipid translocation; and positive regulation of protein exit from endoplasmic reticulum. Predicted to be part of phospholipid-translocating ATPase complex. Predicted to be active in Golgi apparatus; endoplasmic reticulum; and plasma membrane. Orthologous to human TMEM30B (transmembrane protein 30B); INTERACTS WITH 17beta-estradiol; 2,4-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: INFERRED
Previously known as: cell cycle control protein 50B; LOC314224
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,987,471 - 97,990,546 (-)NCBIGRCr8
mRatBN7.2692,251,626 - 92,254,702 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl692,249,790 - 92,254,842 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx692,641,002 - 92,644,082 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,940,531 - 92,943,611 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0692,368,389 - 92,371,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0696,439,607 - 96,442,682 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl696,439,607 - 96,442,682 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06105,870,491 - 105,873,566 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4696,029,115 - 96,032,190 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1696,033,815 - 96,035,593 (-)NCBI
Celera690,712,443 - 90,715,518 (-)NCBICelera
Cytogenetic Map6q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
melanoma  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:20510206   PMID:21914794  


Genomics

Comparative Map Data
Tmem30b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8697,987,471 - 97,990,546 (-)NCBIGRCr8
mRatBN7.2692,251,626 - 92,254,702 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl692,249,790 - 92,254,842 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx692,641,002 - 92,644,082 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0692,940,531 - 92,943,611 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0692,368,389 - 92,371,469 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0696,439,607 - 96,442,682 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl696,439,607 - 96,442,682 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06105,870,491 - 105,873,566 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4696,029,115 - 96,032,190 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1696,033,815 - 96,035,593 (-)NCBI
Celera690,712,443 - 90,715,518 (-)NCBICelera
Cytogenetic Map6q24NCBI
TMEM30B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381461,277,370 - 61,281,338 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1461,277,370 - 61,281,761 (-)EnsemblGRCh38hg38GRCh38
GRCh371461,744,088 - 61,748,056 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361460,813,841 - 60,818,283 (-)NCBINCBI36Build 36hg18NCBI36
Celera1441,794,372 - 41,798,814 (-)NCBICelera
Cytogenetic Map14q23.1NCBI
HuRef1441,907,447 - 41,911,901 (-)NCBIHuRef
CHM1_11461,683,484 - 61,687,926 (-)NCBICHM1_1
T2T-CHM13v2.01455,483,965 - 55,487,943 (-)NCBIT2T-CHM13v2.0
Tmem30b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391273,589,888 - 73,593,169 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1273,590,176 - 73,593,166 (-)EnsemblGRCm39 Ensembl
GRCm381273,543,114 - 73,546,395 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1273,543,402 - 73,546,392 (-)EnsemblGRCm38mm10GRCm38
MGSCv371274,644,101 - 74,647,382 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361274,461,952 - 74,465,233 (-)NCBIMGSCv36mm8
Celera1274,649,888 - 74,653,169 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1230.65NCBI
Tmem30b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554668,426,735 - 8,427,793 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554668,426,706 - 8,430,851 (+)NCBIChiLan1.0ChiLan1.0
TMEM30B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21562,408,788 - 62,453,706 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11461,625,301 - 61,628,664 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01441,880,759 - 41,882,090 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11460,135,989 - 60,139,390 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1460,138,410 - 60,139,780 (-)Ensemblpanpan1.1panPan2
TMEM30B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha835,936,392 - 35,939,911 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0836,416,593 - 36,420,113 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl836,417,354 - 36,420,119 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1836,026,784 - 36,030,301 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0836,104,285 - 36,107,798 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0836,466,075 - 36,469,596 (-)NCBIUU_Cfam_GSD_1.0
Tmem30b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864068,798,945 - 68,802,382 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364955,391,319 - 5,392,380 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364955,390,078 - 5,392,726 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM30B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1190,170,034 - 190,171,095 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11190,161,201 - 190,171,726 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21211,526,140 - 211,529,424 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM30B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12438,444,590 - 38,452,847 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2438,444,681 - 38,445,736 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605326,704,685 - 26,716,131 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem30b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473439,876,628 - 39,877,686 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473439,876,577 - 39,880,009 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tmem30b
10 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:38
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000010923
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
634330Pia16Pristane induced arthritis QTL 163.9joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)645790088104200226Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)672202632115200186Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)689762877106752806Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)658632962103632962Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
1558641Cm47Cardiac mass QTL 472.90.001heart mass (VT:0007028)heart wet weight (CMO:0000069)657730540104085867Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)673463459109394713Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)682523650110548006Rat
1641904Alcrsp4Alcohol response QTL 4response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)667262953112262953Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)681132889104393926Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
70196BpQTLcluster7Blood pressure QTL cluster 76.82arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)672202632117202632Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)683190345106747639Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)671201409116201409Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)661747639106747639Rat
6893332Cm74Cardiac mass QTL 740.40.64heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)657730540104085867Rat
1300076Glom8Glomerulus QTL 879e-09kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 8 15 100 83 90 59 21 59 6 169 50 88 45 59 31

Sequence


Ensembl Acc Id: ENSRNOT00000010923   ⟹   ENSRNOP00000010923
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl692,249,790 - 92,254,842 (-)Ensembl
Rnor_6.0 Ensembl696,439,607 - 96,442,682 (-)Ensembl
RefSeq Acc Id: NM_001080380   ⟹   NP_001073849
RefSeq Status: INFERRED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8697,987,471 - 97,990,546 (-)NCBI
mRatBN7.2692,251,626 - 92,254,702 (-)NCBI
Rnor_6.0696,439,607 - 96,442,682 (-)NCBI
Rnor_5.06105,870,491 - 105,873,566 (-)NCBI
RGSC_v3.4696,029,115 - 96,032,190 (-)RGD
Celera690,712,443 - 90,715,518 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001073849 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDM03617 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010923.1
RefSeq Acc Id: NP_001073849   ⟸   NM_001080380
- UniProtKB: D3Z9E9 (UniProtKB/TrEMBL),   A6HC62 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010923   ⟸   ENSRNOT00000010923

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3Z9E9-F1-model_v2 AlphaFold D3Z9E9 1-353 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694666
Promoter ID:EPDNEW_R5190
Type:multiple initiation site
Name:Tmem30b_1
Description:transmembrane protein 30B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0696,442,714 - 96,442,774EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308732 AgrOrtholog
BioCyc Gene G2FUF-37106 BioCyc
Ensembl Genes ENSRNOG00000008046 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000010923.4 UniProtKB/TrEMBL
InterPro DUF284_TM_euk UniProtKB/TrEMBL
KEGG Report rno:314224 UniProtKB/TrEMBL
NCBI Gene 314224 ENTREZGENE
PANTHER DUF284_TM_euk UniProtKB/TrEMBL
  PTHR10926:SF19 UniProtKB/TrEMBL
Pfam CDC50 UniProtKB/TrEMBL
PhenoGen Tmem30b PhenoGen
PIRSF DUF284_TM_euk UniProtKB/TrEMBL
RatGTEx ENSRNOG00000008046 RatGTEx
UniProt A6HC62 ENTREZGENE, UniProtKB/TrEMBL
  D3Z9E9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-04-30 Tmem30b  transmembrane protein 30B   Tmem30b_predicted  transmembrane protein 30B (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Tmem30b_predicted  transmembrane protein 30B (predicted)      Symbol and Name status set to approved 70820 APPROVED