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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metformin
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Accession:CHEBI:6801 term browser browse the term
Definition:A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Synonyms:exact_synonym: N,N-dimethyltriimidodicarbonic diamide
 related_synonym: 1,1-Dimethylbiguanide;   Formula=C4H11N5;   InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8);   InChIKey=XZWYZXLIPXDOLR-UHFFFAOYSA-N;   LA 6023;   N(1),N(1)-dimethylbiguanide;   N,N-dimethylbiguanide;   N,N-dimethyldiguanide;   N,N-dimethylguanylguanidine;   N,N-dimethylimidodicarbonimidic diamide;   SMILES=CN(C)C(=N)NC(N)=N;   dimethylbiguanide;   dimethyldiguanide;   metformina;   metformine;   metforminum
 xref: CAS:657-24-9;   DrugBank:DB00331;   Drug_Central:1725;   FooDB:FDB022739;   HMDB:HMDB0001921;   KEGG:C07151;   KEGG:D04966;   LINCS:LSM-4730
 xref_mesh: MESH:D008687
 xref: PDBeChem:MF8;   PMID:10900588;   PMID:10983737;   PMID:10999803;   PMID:11012555;   PMID:11126815;   PMID:11192132;   PMID:11257323;   PMID:11544610;   PMID:11772907;   PMID:12086935;   PMID:12406042;   PMID:12436333;   PMID:12630933;   PMID:12909816;   PMID:15261814;   PMID:15606381;   PMID:15650645;   PMID:15717887;   PMID:15932841;   PMID:16294070;   PMID:16520442;   PMID:16941277;   PMID:17062558;   PMID:18212742;   PMID:18608522;   PMID:23077661;   PMID:23540700;   PMID:24428821;   PMID:28919040;   PMID:31208831;   PMID:33191721;   Reaxys:606492;   Wikipedia:Metformin
 cyclic_relationship: is_conjugate_base_of CHEBI:90688



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metformin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase increases expression EXP Metformin results in increased expression of AACS mRNA CTD PMID:31324951 NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954
JBrowse link
G Aars1 alanyl-tRNA synthetase 1 increases expression EXP Metformin results in increased expression of AARS mRNA CTD PMID:25596134 NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression
multiple interactions
EXP
ISO
Metformin results in decreased expression of ABCB11 mRNA
[Metformin co-treated with Ethinyl Estradiol] results in decreased expression of ABCB11 protein
CTD PMID:27765674 PMID:34058177 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases expression
ISO Metformin inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [RELA protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 protein]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of ABCB1 protein]
Metformin results in decreased expression of ABCB1 mRNA; Metformin results in decreased expression of ABCB1 protein
CTD PMID:21054339 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP Metformin results in increased expression of ABCB1B mRNA CTD PMID:19022234 NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP Metformin results in increased expression of ABCB4 mRNA CTD PMID:31324951 NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 decreases expression EXP Metformin results in decreased expression of ABCB6 mRNA CTD PMID:25596134 NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 affects expression EXP Metformin affects the expression of ABCB9 mRNA CTD PMID:25596134 NCBI chr12:32,499,225...32,531,932
Ensembl chr12:32,499,225...32,531,931
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Metformin results in increased expression of ABCC2 mRNA CTD PMID:19022234 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP Metformin results in decreased expression of ABCC3 mRNA CTD PMID:25596134 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 multiple interactions ISO Metformin inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCC4 protein] CTD PMID:34058177 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ABCC5 mRNA] CTD PMID:29095437 NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 multiple interactions ISO [rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 mRNA alternative form; [rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 protein alternative form CTD PMID:20823565 NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression
increases expression
EXP Metformin results in decreased expression of ABCG5 mRNA
Metformin results in increased expression of ABCG5 mRNA
CTD PMID:27765674 PMID:31324951 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP Metformin results in increased expression of ABCG8 mRNA CTD PMID:31324951 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B decreases expression EXP Metformin results in decreased expression of ABHD4 mRNA CTD PMID:25596134 NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of ABL1 mRNA CTD PMID:29309887 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Ablim3 actin binding LIM protein family, member 3 increases expression EXP Metformin results in increased expression of ABLIM3 mRNA CTD PMID:31324951 NCBI chr18:55,256,135...55,376,629
Ensembl chr18:55,257,583...55,376,380
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression
multiple interactions
increases expression
increases phosphorylation
affects phosphorylation
ISO
EXP
Metformin results in decreased expression of ACACA mRNA; Metformin results in decreased expression of ACACA protein
Metformin inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]
Metformin results in increased expression of ACACA mRNA
Metformin results in increased phosphorylation of ACACA protein
Trientine inhibits the reaction [Metformin results in increased phosphorylation of ACACA protein]
Metformin analog affects the phosphorylation of ACACA protein
CTD PMID:16760380 PMID:16873680 PMID:20956498 PMID:22492524 PMID:29991592 More... NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acacb acetyl-CoA carboxylase beta increases phosphorylation ISO Metformin results in increased phosphorylation of ACACB protein CTD PMID:16873680 NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP Metformin results in increased expression of ACAT2 mRNA CTD PMID:31324951 NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
JBrowse link
G Ace2 angiotensin I converting enzyme 2 increases expression ISO Metformin results in increased expression of ACE2 mRNA CTD PMID:32808185 NCBI chr  X:30,293,597...30,340,961
Ensembl chr  X:30,293,589...30,340,977
JBrowse link
G Ache acetylcholinesterase decreases activity
multiple interactions
ISO
EXP
Metformin results in decreased activity of ACHE protein
Metformin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of ACHE protein]
CTD PMID:28259689 PMID:33823243 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Acly ATP citrate lyase multiple interactions
affects expression
ISO
EXP
[Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein
Metformin affects the expression of ACLY mRNA
CTD PMID:28576465 PMID:31324951 NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases expression EXP Metformin results in decreased expression of ACMSD mRNA CTD PMID:31324951 NCBI chr13:39,200,486...39,244,337
Ensembl chr13:39,200,314...39,245,209
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP Metformin results in increased expression of ACOT2 mRNA CTD PMID:31324951 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acot3 acyl-CoA thioesterase 3 increases expression EXP Metformin results in increased expression of ACOT3 mRNA CTD PMID:31324951 NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,723,326...103,729,482
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression
multiple interactions
EXP
ISO
Metformin results in decreased expression of ACSL1 mRNA
Metformin inhibits the reaction [Oxygen deficiency results in increased expression of ACSL1 mRNA]
CTD PMID:25596134 PMID:33476677 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 increases expression EXP Metformin results in increased expression of ACSM3 mRNA CTD PMID:31324951 NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle increases expression EXP Metformin results in increased expression of ACTA1 mRNA CTD PMID:31324951 NCBI chr19:51,883,713...51,886,725
Ensembl chr19:51,883,715...51,886,742
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Metformin inhibits the reaction [Dietary Fats results in increased expression of ACTA2 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]] CTD PMID:27551045 PMID:30551545 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
JBrowse link
G Actn1 actinin, alpha 1 increases expression EXP Metformin results in increased expression of ACTN1 mRNA CTD PMID:19022234 NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO Metformin inhibits the reaction [Folic Acid results in increased expression of ADGRE1 mRNA] CTD PMID:29380373 NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression EXP Metformin results in decreased expression of ADH4 mRNA CTD PMID:31324951 NCBI chr 2:226,948,717...226,966,747 JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions
increases expression
ISO
EXP
Metformin results in decreased expression of ADIPOQ mRNA
Metformin inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]
Metformin results in increased expression of ADIPOQ protein
Metformin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA]
Cimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA]
CTD PMID:20956498 PMID:25108154 PMID:30256492 PMID:32652086 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
JBrowse link
G Adipor1 adiponectin receptor 1 increases expression EXP Metformin results in increased expression of ADIPOR1 mRNA CTD PMID:29991592 NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP metformin increases expression of Adipor2 mRNA in liver RGD PMID:24797033 RGD:25824940 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Aen apoptosis enhancing nuclease multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of AEN mRNA] CTD PMID:29095437 NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Metformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Metformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] CTD PMID:22467055 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
JBrowse link
G Agrn agrin decreases expression EXP Metformin results in decreased expression of AGRN mRNA CTD PMID:25596134 NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
JBrowse link
G Agrp agouti related neuropeptide multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA] CTD PMID:32652086 NCBI chr19:33,447,992...33,523,068
Ensembl chr19:33,447,992...33,449,584
JBrowse link
G Agt angiotensinogen multiple interactions ISO Metformin inhibits the reaction [AGT protein results in increased activity of and results in increased phosphorylation of HMGCR protein]; Metformin inhibits the reaction [AGT protein results in increased cleavage of and affects the localization of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased expression of LDLR protein]; Metformin inhibits the reaction [AGT protein results in increased expression of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of TNF protein] CTD PMID:29499335 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression
affects activity
multiple interactions
ISO
EXP
Metformin results in decreased expression of AHR mRNA; Metformin results in decreased expression of AHR protein
Metformin affects the activity of AHR protein
Metformin inhibits the reaction [SP1 protein results in increased expression of AHR protein]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]
CTD PMID:25110054 PMID:25596134 PMID:25697376 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO Metformin inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein] CTD PMID:27562556 NCBI chr  X:127,650,223...127,689,356
Ensembl chr  X:127,650,226...127,689,256
JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 decreases expression EXP Metformin results in decreased expression of AIFM2 mRNA CTD PMID:25596134 NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236
JBrowse link
G Ak3 adenylate kinase 3 decreases expression EXP Metformin results in decreased expression of AK3 mRNA CTD PMID:25596134 NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625
JBrowse link
G Ak4 adenylate kinase 4 decreases expression EXP Metformin results in decreased expression of AK4 mRNA CTD PMID:25596134 NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
increases phosphorylation
decreases phosphorylation
ISO
EXP
[Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with INS protein] results in increased phosphorylation of AKT1 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of AKT1 mRNA; [Simvastatin co-treated with Metformin] results in decreased phosphorylation of AKT1 protein; Metformin inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]
Metformin results in increased phosphorylation of AKT1 protein
Metformin decreases phosphorylation of AKT1 protein in epithelial cell of alveolus of lung
Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]
Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Testosterone results in increased phosphorylation of AKT1 protein]
CTD
RGD
PMID:16385087 PMID:21664031 PMID:25412314 PMID:26492952 PMID:26835874 More... RGD:150404268 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein] CTD PMID:27270450 NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
JBrowse link
G Akt3 AKT serine/threonine kinase 3 decreases expression ISO Metformin results in decreased expression of AKT3 mRNA CTD PMID:32589349 NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression EXP Metformin results in decreased expression of ALAS2 mRNA CTD PMID:31324951 NCBI chr  X:19,463,146...19,486,526
Ensembl chr  X:19,463,171...19,486,519
JBrowse link
G Alb albumin multiple interactions EXP Metformin inhibits the reaction [Streptozocin results in increased expression of ALB protein] CTD PMID:33639173 NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression EXP Metformin results in increased expression of ALDH18A1 mRNA CTD PMID:25596134 NCBI chr 1:239,375,657...239,407,967
Ensembl chr 1:239,375,669...239,407,890
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Metformin results in increased expression of ALDH1A1 mRNA CTD PMID:31324951 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Metformin results in increased expression of ALDOA mRNA CTD PMID:25596134 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression EXP Metformin results in decreased expression of ALOX15 mRNA CTD PMID:31324951 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression EXP Metformin results in decreased expression of AMBP mRNA CTD PMID:25596134 NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
JBrowse link
G Angpt1 angiopoietin 1 decreases expression EXP Metformin results in decreased expression of ANGPT1 mRNA CTD PMID:31324951 NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression
increases expression
EXP Metformin results in decreased expression of ANGPTL4 mRNA
Metformin results in increased expression of ANGPTL4 mRNA
CTD PMID:25596134 PMID:31324951 NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
JBrowse link
G Angptl8 angiopoietin-like 8 increases expression EXP Metformin results in increased expression of ANGPTL8 mRNA CTD PMID:31324951 NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:20,376,462...20,378,490
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of APAF1 mRNA CTD PMID:29309887 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of APEX1 mRNA] CTD PMID:25697376 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Apoa5 apolipoprotein A5 decreases expression EXP Metformin results in decreased expression of APOA5 mRNA CTD PMID:31324951 NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
JBrowse link
G Apof apolipoprotein F decreases expression EXP Metformin results in decreased expression of APOF mRNA CTD PMID:31324951 NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 multiple interactions
increases expression
EXP Metformin promotes the reaction [APPL1 protein binds to RAB5A protein]
Metformin results in increased expression of APPL1 protein
CTD PMID:29991592 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
JBrowse link
G Aqp7 aquaporin 7 increases expression EXP Metformin results in increased expression of AQP7 mRNA CTD PMID:31324951 NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
JBrowse link
G Arfgap3 ADP-ribosylation factor GTPase activating protein 3 increases expression EXP Metformin results in increased expression of ARFGAP3 mRNA CTD PMID:31324951 NCBI chr 7:114,432,873...114,479,206
Ensembl chr 7:114,432,873...114,479,208
JBrowse link
G Arfgef2 ADP ribosylation factor guanine nucleotide exchange factor 2 increases expression EXP Metformin results in increased expression of ARFGEF2 mRNA CTD PMID:25596134 NCBI chr 3:155,547,504...155,633,652
Ensembl chr 3:155,547,538...155,630,856
JBrowse link
G Arg1 arginase 1 multiple interactions EXP
ISO
Metformin inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA]
Metformin inhibits the reaction [IL13 protein results in increased expression of ARG1 mRNA]
CTD PMID:25108154 PMID:26497364 NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
JBrowse link
G Arhgef10 Rho guanine nucleotide exchange factor 10 decreases expression EXP Metformin results in decreased expression of ARHGEF10 mRNA CTD PMID:25596134 NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173
JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 decreases expression EXP Metformin results in decreased expression of ARL1 mRNA CTD PMID:25596134 NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression EXP Metformin results in decreased expression of ARNTL mRNA CTD PMID:31324951 NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ARPC5L mRNA] CTD PMID:29095437 NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538
JBrowse link
G Arrdc3 arrestin domain containing 3 decreases expression EXP Metformin results in decreased expression of ARRDC3 mRNA CTD PMID:31324951 NCBI chr 2:11,137,443...11,149,978
Ensembl chr 2:11,137,460...11,149,978
JBrowse link
G Asl argininosuccinate lyase decreases expression EXP Metformin results in decreased expression of ASL mRNA CTD PMID:31324951 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Metformin results in increased expression of ASNS mRNA CTD PMID:25596134 PMID:31324951 NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP Metformin results in increased expression of ATF3 mRNA CTD PMID:25596134 NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
JBrowse link
G Atf4 activating transcription factor 4 affects activity
multiple interactions
EXP
ISO
Metformin affects the activity of ATF4 protein
Metformin inhibits the reaction [Rotenone results in increased expression of ATF4 mRNA]
CTD PMID:25596134 PMID:32189544 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atf5 activating transcription factor 5 increases expression EXP Metformin results in increased expression of ATF5 mRNA CTD PMID:31324951 NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Metformin inhibits the reaction [Rotenone results in increased expression of ATF6 mRNA] CTD PMID:32189544 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
JBrowse link
G Atm ATM serine/threonine kinase affects response to substance
increases expression
ISO ATM gene SNP affects the susceptibility to Metformin
Metformin increases expression of ATM protein in epithelial cell of alveolus of lung
CTD
RGD
PMID:21186350 PMID:23632475 RGD:150404268 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression EXP Metformin results in decreased expression of ATP1A2 mRNA CTD PMID:31324951 NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 increases expression EXP Metformin results in increased expression of ATP1A3 mRNA CTD PMID:31324951 NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of ATP2A2 protein] CTD PMID:30290168 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp5mc2 ATP synthase membrane subunit c locus 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ATP5G2 mRNA] CTD PMID:29095437 NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 decreases expression EXP Metformin results in decreased expression of ATP6V0D2 mRNA CTD PMID:31324951 NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of ATR mRNA CTD PMID:29309887 NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
JBrowse link
G Aurkb aurora kinase B increases expression EXP Metformin results in increased expression of AURKB mRNA CTD PMID:25596134 NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
JBrowse link
G Aven apoptosis and caspase activation inhibitor multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of AVEN mRNA CTD PMID:29309887 NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634
JBrowse link
G B2m beta-2 microglobulin multiple interactions EXP Metformin inhibits the reaction [Streptozocin results in increased expression of B2M protein] CTD PMID:33639173 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions
ISO Metformin results in increased expression of BAD protein
Cisplatin promotes the reaction [Metformin results in increased expression of BAD protein]; Metformin inhibits the reaction [INS protein results in decreased expression of BAD protein]
CTD PMID:21388661 PMID:33651899 NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
JBrowse link
G Bag1 BAG cochaperone 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of BAG1 mRNA CTD PMID:29309887 NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
affects expression
increases expression
ISO
EXP
Cisplatin promotes the reaction [Metformin results in increased expression of BAX protein]
Metformin affects the expression of BAX protein
Metformin inhibits the reaction [Glucose results in increased expression of BAX protein]; Metformin inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]
Metformin results in increased expression of BAX mRNA
CTD PMID:21388661 PMID:25596134 PMID:26492952 PMID:29226720 PMID:30144576 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcar3 BCAR3 adaptor protein, NSP family member affects expression EXP Metformin affects the expression of BCAR3 mRNA CTD PMID:25596134 NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
JBrowse link
G Bcat2 branched chain amino acid transaminase 2 decreases expression EXP Metformin results in decreased expression of BCAT2 mRNA CTD PMID:25596134 PMID:31324951 NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of BCL2 protein
Metformin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Metformin inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]
[Paclitaxel co-treated with Metformin] results in decreased expression of BCL2 mRNA; Cisplatin promotes the reaction [Metformin results in decreased expression of BCL2 protein]
CTD PMID:21388661 PMID:26492952 PMID:29226720 PMID:29309887 PMID:30144576 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO Cisplatin promotes the reaction [Metformin results in decreased expression of BCL2L1 protein] CTD PMID:21388661 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression EXP Metformin results in increased expression of BCL6 mRNA CTD PMID:31324951 NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Metformin inhibits the reaction [Methamphetamine results in decreased expression of BDNF protein] CTD PMID:30742852 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 affects expression EXP Metformin affects the expression of BHLHE40 mRNA CTD PMID:25596134 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 decreases expression ISO Metformin results in decreased expression of BIRC5 protein CTD PMID:29226720 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bmf Bcl2 modifying factor decreases expression EXP Metformin results in decreased expression of BMF mRNA CTD PMID:25596134 NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Metformin results in increased expression of BNIP3 mRNA CTD PMID:25596134 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Bpgm bisphosphoglycerate mutase decreases expression EXP Metformin results in decreased expression of BPGM mRNA CTD PMID:31324951 NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581
JBrowse link
G Brd2 bromodomain containing 2 affects expression EXP Metformin affects the expression of BRD2 mRNA CTD PMID:25596134 NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388
JBrowse link
G Btg2 BTG anti-proliferation factor 2 affects expression
decreases expression
EXP Metformin affects the expression of BTG2 mRNA
Metformin results in decreased expression of BTG2 mRNA
CTD PMID:25596134 PMID:31324951 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D decreases expression EXP Metformin results in decreased expression of CACNA1D mRNA CTD PMID:25596134 NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
JBrowse link
G Cars cysteinyl-tRNA synthetase increases expression EXP Metformin results in increased expression of CARS mRNA CTD PMID:25596134 PMID:31324951 NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CASP1 mRNA CTD PMID:29309887 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
JBrowse link
G Casp14 caspase 14 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CASP14 mRNA CTD PMID:29309887 NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
decreases activity
increases activity
ISO
EXP
[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA; Cisplatin promotes the reaction [Metformin results in increased activity of CASP3 protein]; Metformin inhibits the reaction [sunitinib results in increased cleavage of CASP3 protein]; Sodium Salicylate promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of CASP3 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]
Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]
Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of CASP3 protein]; Metformin inhibits the reaction [Glucose results in increased activity of CASP3 protein]
Metformin results in decreased activity of CASP3 protein
CTD PMID:15531508 PMID:21388661 PMID:21906609 PMID:27551045 PMID:29095437 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp4 caspase 4 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CASP4 mRNA CTD PMID:29309887 NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO
EXP
Cisplatin promotes the reaction [Metformin results in increased activity of CASP7 protein]; Metformin inhibits the reaction [Sunitinib results in increased cleavage of CASP7 protein]
dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]
CTD PMID:21388661 PMID:21906609 PMID:30551545 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 decreases activity
multiple interactions
ISO Metformin results in decreased activity of CASP8 protein
[Paclitaxel co-treated with Metformin] results in increased expression of CASP8 mRNA
CTD PMID:15531508 PMID:29309887 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casq1 calsequestrin 1 decreases expression EXP Metformin results in decreased expression of CASQ1 mRNA CTD PMID:31324951 NCBI chr13:84,670,648...84,680,339
Ensembl chr13:84,670,649...84,680,339
JBrowse link
G Cat catalase multiple interactions
increases activity
decreases expression
increases expression
EXP
ISO
Metformin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased activity of CAT protein]; Metformin inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of CAT mRNA]
Metformin results in increased activity of CAT protein
Metformin promotes the reaction [Carbon Tetrachloride results in increased activity of CAT protein]
Metformin results in decreased expression of CAT mRNA
Metformin results in increased expression of CAT mRNA
CTD PMID:15531508 PMID:21457706 PMID:22627169 PMID:22666520 PMID:24717679 More... NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cby1 chibby family member 1, beta catenin antagonist multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CBY1 mRNA] CTD PMID:29095437 NCBI chr 7:111,216,835...111,223,305 JBrowse link
G Ccdc38 coiled-coil domain containing 38 increases expression EXP Metformin results in increased expression of CCDC38 mRNA CTD PMID:31324951 NCBI chr 7:28,055,883...28,129,938
Ensembl chr 7:28,059,798...28,130,441
JBrowse link
G Ccdc77 coiled-coil domain containing 77 increases expression EXP Metformin results in increased expression of CCDC77 mRNA CTD PMID:31324951 NCBI chr 4:153,534,184...153,566,059
Ensembl chr 4:153,534,187...153,566,545
JBrowse link
G Ccdc90b coiled-coil domain containing 90B increases expression EXP Metformin results in increased expression of CCDC90B mRNA CTD PMID:25596134 NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of CCL2 mRNA
Metformin inhibits the reaction [AGT protein results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [Folic Acid results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL2 mRNA]
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA]
CTD PMID:20956498 PMID:25108154 PMID:26497364 PMID:29380373 PMID:29499335 More... NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl24 C-C motif chemokine ligand 24 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of CCL24 mRNA] CTD PMID:26497364 NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893
JBrowse link
G Ccl27 C-C motif chemokine ligand 27 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of CCL27A mRNA] CTD PMID:29095437 NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of CCL7 mRNA] CTD PMID:26497364 NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP Metformin results in decreased expression of CCN2 mRNA CTD PMID:31324951 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCNB1 mRNA CTD PMID:29309887 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccnb2 cyclin B2 multiple interactions
increases expression
ISO
EXP
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNB2 mRNA
Metformin results in increased expression of CCNB2 mRNA
CTD PMID:29309887 PMID:31324951 NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
JBrowse link
G Ccnc cyclin C multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCNC mRNA CTD PMID:29309887 NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
JBrowse link
G Ccnd1 cyclin D1 multiple interactions
decreases expression
ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCND1 mRNA
Metformin results in decreased expression of CCND1 protein
CTD PMID:29226720 PMID:29309887 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
EXP
ISO
Metformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein]
[Paclitaxel co-treated with Metformin] results in decreased expression of CCND2 mRNA
Metformin results in decreased expression of CCND2 protein
CTD PMID:16760380 PMID:29309887 NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
JBrowse link
G Ccne1 cyclin E1 multiple interactions
decreases expression
EXP
ISO
Metformin inhibits the reaction [FSHB protein results in increased expression of CCNE1 protein]
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNE1 mRNA
Metformin results in decreased expression of CCNE1 protein
CTD PMID:16760380 PMID:29309887 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Ccnf cyclin F multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCNF mRNA CTD PMID:29309887 NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
JBrowse link
G Ccng1 cyclin G1 increases expression
multiple interactions
EXP
ISO
Metformin results in increased expression of CCNG1 mRNA
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNG1 mRNA
CTD PMID:19022234 PMID:29309887 NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
JBrowse link
G Ccng2 cyclin G2 decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of CCNG2 mRNA
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNG2 mRNA
CTD PMID:25596134 PMID:29309887 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA] CTD PMID:26497364 NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
JBrowse link
G Cd14 CD14 molecule increases expression ISO Metformin results in increased expression of CD14 protein CTD PMID:26036281 NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CD40LG mRNA CTD PMID:29309887 NCBI chr  X:135,127,119...135,138,302
Ensembl chr  X:135,126,969...135,138,306
JBrowse link
G Cd52 CD52 molecule decreases expression EXP Metformin results in decreased expression of CD52 mRNA CTD PMID:31324951 NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348
JBrowse link
G Cd63 Cd63 molecule increases expression EXP Metformin results in increased expression of CD63 mRNA CTD PMID:31324951 NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
JBrowse link
G Cd74 CD74 molecule decreases expression EXP Metformin results in decreased expression of CD74 mRNA CTD PMID:31324951 NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
JBrowse link
G Cdc16 cell division cycle 16 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDC16 mRNA CTD PMID:29309887 NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDC20 mRNA CTD PMID:29309887 NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDC25A mRNA CTD PMID:29309887 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdc25b cell division cycle 25B decreases expression EXP Metformin results in decreased expression of CDC25B mRNA CTD PMID:31324951 NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDC34 mRNA CTD PMID:29309887 NCBI chr 7:10,017,588...10,023,586
Ensembl chr 7:10,017,588...10,023,186
JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO Metformin results in decreased expression of CDC42 mRNA CTD PMID:32589349 NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
JBrowse link
G Cdip1 cell death-inducing p53 target 1 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CDIP1 mRNA] CTD PMID:29095437 NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK1 mRNA CTD PMID:29309887 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK2 mRNA CTD PMID:29309887 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions
increases expression
ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK4 mRNA
Metformin results in increased expression of CDK4 protein
CTD PMID:29226720 PMID:29309887 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK5R1 mRNA CTD PMID:29309887 NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression EXP Metformin results in increased expression of CDK6 mRNA CTD PMID:25596134 NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
JBrowse link
G Cdk7 cyclin-dependent kinase 7 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK7 mRNA CTD PMID:29309887 NCBI chr 2:31,840,545...31,865,447
Ensembl chr 2:31,840,558...31,865,383
JBrowse link
G Cdk8 cyclin-dependent kinase 8 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK8 mRNA CTD PMID:29309887 NCBI chr12:8,737,198...8,805,026 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
EXP Metformin results in increased expression of CDKN1A mRNA
Metformin inhibits the reaction [Testosterone results in decreased expression of CDKN1A mRNA]
CTD PMID:25596134 PMID:26492952 PMID:31324951 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CDKN1B mRNA CTD PMID:29309887 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP Metformin results in decreased expression of CEBPA mRNA CTD PMID:19022234 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
JBrowse link
G Cers5 ceramide synthase 5 increases expression EXP Metformin results in increased expression of CERS5 mRNA CTD PMID:25596134 NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947
JBrowse link
G Cfd complement factor D decreases expression ISO Metformin results in decreased expression of CFD mRNA CTD PMID:17148569 NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA CTD PMID:29309887 NCBI chr 8:36,420,565...36,443,477 JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK2 mRNA CTD PMID:29309887 NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression
multiple interactions
ISO Metformin results in decreased expression of CHUK mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of CHUK mRNA
CTD PMID:32589349 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression EXP Metformin results in decreased expression of CISH mRNA CTD PMID:31324951 NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
JBrowse link
G Ckap2 cytoskeleton associated protein 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CKAP2 mRNA] CTD PMID:29095437 NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913
JBrowse link
G Cldn3 claudin 3 decreases expression EXP Metformin results in decreased expression of CLDN3 mRNA CTD PMID:31324951 NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog decreases expression EXP Metformin results in decreased expression of CMBL mRNA CTD PMID:25596134 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
JBrowse link
G Cnppd1 cyclin Pas1/PHO80 domain containing 1 decreases expression EXP Metformin results in decreased expression of CNPPD1 mRNA CTD PMID:31324951 NCBI chr 9:76,633,475...76,640,164
Ensembl chr 9:76,633,477...76,640,188
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions ISO Metformin inhibits the reaction [Folic Acid results in increased expression of COL4A1 mRNA] CTD PMID:29380373 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
affects expression
EXP Metformin results in decreased expression of CPT1A mRNA
Metformin affects the expression of CPT1A mRNA
CTD PMID:19022234 PMID:31324951 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
JBrowse link
G Cptp ceramide-1-phosphate transfer protein multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CPTP mRNA] CTD PMID:29095437 NCBI chr 5:166,474,947...166,479,103
Ensembl chr 5:166,474,966...166,479,017
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of CREB1 protein] CTD PMID:30742852 NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 multiple interactions
increases expression
ISO
EXP
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CREB3L2 mRNA]
Metformin results in increased expression of CREB3L2 mRNA
CTD PMID:29095437 PMID:31324951 NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763
JBrowse link
G Crebrf CREB3 regulatory factor decreases expression EXP Metformin results in decreased expression of CREBRF mRNA CTD PMID:31324951 NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999
JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 increases expression EXP Metformin results in increased expression of CRELD2 mRNA CTD PMID:31324951 NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543
JBrowse link
G Crot carnitine O-octanoyltransferase increases expression EXP Metformin results in increased expression of CROT mRNA CTD PMID:31324951 NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
JBrowse link
G Crp C-reactive protein decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of CRP protein
Metformin inhibits the reaction [Fructose results in increased expression of CRP protein]
CTD PMID:14557435 PMID:25108154 NCBI chr13:85,131,635...85,175,179
Ensembl chr13:85,124,977...85,175,178
JBrowse link
G Cst3 cystatin C multiple interactions EXP Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein] CTD PMID:30551545 NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
JBrowse link
G Ctdp1 CTD phosphatase subunit 1 increases expression EXP Metformin results in increased expression of CTDP1 mRNA CTD PMID:25596134 NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457
JBrowse link
G Ctdsp2 CTD small phosphatase 2 decreases expression EXP Metformin results in decreased expression of CTDSP2 mRNA CTD PMID:31324951 NCBI chr 7:62,805,400...62,825,306 JBrowse link
G Cth cystathionine gamma-lyase decreases expression EXP Metformin results in decreased expression of CTH mRNA CTD PMID:25596134 NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
JBrowse link
G Ctsc cathepsin C decreases expression EXP Metformin results in decreased expression of CTSC mRNA CTD PMID:25596134 NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
JBrowse link
G Cttn cortactin increases expression EXP Metformin results in increased expression of CTTN mRNA CTD PMID:25596134 NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
JBrowse link
G Cttnbp2nl CTTNBP2 N-terminal like multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of CTTNBP2NL mRNA] CTD PMID:29095437 NCBI chr 2:192,507,963...192,554,548
Ensembl chr 2:192,507,963...192,541,101
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 affects expression EXP Metformin affects the expression of CXCL1 mRNA CTD PMID:31324951 NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression EXP Metformin results in decreased expression of CXCL13 mRNA CTD PMID:31324951 NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of CXCL2 mRNA] CTD PMID:26497364 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression EXP Metformin results in decreased expression of CXCL9 mRNA CTD PMID:31324951 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of CYBA mRNA
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]
CTD PMID:15531508 PMID:27634381 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP Metformin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein] CTD PMID:16760380 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions
affects expression
ISO
EXP
Metformin results in decreased expression of CYP17A1 mRNA
Metformin inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]
Metformin affects the expression of CYP17A1 mRNA
CTD PMID:23166782 PMID:31324951 PMID:32298659 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP Metformin inhibits the reaction [FSHB protein results in increased expression of CYP19A1 protein] CTD PMID:16760380 NCBI chr 8:54,553,165...54,580,758
Ensembl chr 8:54,553,165...54,580,758
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
increases expression
ISO
EXP
Metformin promotes the reaction [Streptozocin results in increased expression of CYP1A1 mRNA]
Metformin results in decreased expression of CYP1A1 mRNA
Metformin results in decreased expression of CYP1A1 mRNA; Metformin results in decreased expression of CYP1A1 protein
Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of and results in increased activity of CYP1A1 protein]; Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Metformin results in increased expression of CYP1A1 mRNA
CTD PMID:22342832 PMID:25110054 PMID:25596134 PMID:25697376 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
ISO
EXP
Metformin results in increased expression of CYP1A2 mRNA
Metformin results in decreased expression of CYP1A2 mRNA
CTD PMID:19022234 PMID:25596134 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases expression
ISO Metformin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Metformin results in decreased expression of CYP1B1 mRNA; Metformin results in decreased expression of CYP1B1 protein
CTD PMID:25110054 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 decreases expression
multiple interactions
ISO Metformin results in decreased expression of CYP27A1 mRNA
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP27A1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP27A1 protein
CTD PMID:34058177 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CYP27B1 mRNA CTD PMID:29309887 NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO Metformin results in increased expression of CYP2B10 mRNA CTD PMID:22342832 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Metformin promotes the reaction [Streptozocin results in increased expression of CYP2B9 mRNA] CTD PMID:22342832 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 increases expression EXP Metformin results in increased expression of CYP2C12 mRNA CTD PMID:31324951 NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO Metformin results in increased expression of CYP2E1 mRNA CTD PMID:22342832 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression
decreases expression
multiple interactions
ISO Metformin results in increased expression of CYP3A4 mRNA
Metformin results in decreased expression of CYP3A4 mRNA
Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein]
CTD PMID:19022234 PMID:21920351 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
increases expression
affects expression
EXP
ISO
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein]
Metformin results in increased expression of CYP7A1 protein
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP7A1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP7A1 protein
Metformin affects the expression of CYP7A1 mRNA
CTD PMID:31100278 PMID:31324951 PMID:34058177 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Cyp7b1 cytochrome P450 family 7 subfamily B member 1 multiple interactions ISO [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP7B1 mRNA CTD PMID:34058177 NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression
decreases expression
multiple interactions
EXP
ISO
Metformin results in increased expression of CYP8B1 mRNA
Metformin results in decreased expression of CYP8B1 protein
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP8B1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP8B1 protein
CTD PMID:31324951 PMID:34058177 NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
JBrowse link
G Dapk1 death associated protein kinase 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of DAPK1 mRNA CTD PMID:29309887 NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase decreases expression EXP Metformin results in decreased expression of DCXR mRNA CTD PMID:31324951 NCBI chr10:106,006,404...106,008,294 JBrowse link
G Ddhd1 DDHD domain containing 1 increases expression EXP Metformin results in increased expression of DDHD1 mRNA CTD PMID:31324951 NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952
JBrowse link
G Ddi2 DNA damage inducible 1 homolog 2 decreases expression EXP Metformin results in decreased expression of DDI2 mRNA CTD PMID:31324951 NCBI chr 5:153,989,596...154,035,342
Ensembl chr 5:153,995,589...154,035,283
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression
multiple interactions
EXP
ISO
Metformin results in increased expression of DDIT3 mRNA
Metformin inhibits the reaction [Rotenone results in increased expression of DDIT3 mRNA]
CTD PMID:25596134 PMID:32189544 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression
multiple interactions
increases expression
EXP
ISO
Metformin results in decreased expression of DDIT4 mRNA
[Metformin co-treated with Pioglitazone] results in increased expression of DDIT4 mRNA
Metformin results in increased expression of DDIT4 mRNA
CTD PMID:25596134 PMID:32589349 NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like multiple interactions ISO [Metformin co-treated with Pioglitazone] results in increased expression of DDIT4L mRNA CTD PMID:32589349 NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
JBrowse link
G Ddx17 DEAD-box helicase 17 increases expression EXP Metformin results in increased expression of DDX17 mRNA CTD PMID:25596134 NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193
JBrowse link
G Ddx24 DEAD-box helicase 24 increases expression EXP Metformin results in increased expression of DDX24 mRNA CTD PMID:25596134 NCBI chr 6:122,564,767...122,582,032
Ensembl chr 6:122,564,767...122,581,927
JBrowse link
G Denr density regulated reinitiation and release factor multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DENR mRNA] CTD PMID:29095437 NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein multiple interactions
decreases expression
ISO [Metformin co-treated with Pioglitazone] results in decreased expression of DEPTOR mRNA
Metformin results in decreased expression of DEPTOR mRNA
CTD PMID:32589349 NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
JBrowse link
G Dffa DNA fragmentation factor subunit alpha multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of DFFA mRNA CTD PMID:29309887 NCBI chr 5:159,540,718...159,553,639
Ensembl chr 5:159,540,715...159,553,633
JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression EXP Metformin results in increased expression of DGKA mRNA CTD PMID:25596134 NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
JBrowse link
G Dhx37 DEAH-box helicase 37 increases expression EXP Metformin results in increased expression of DHX37 mRNA CTD PMID:25596134 NCBI chr12:31,194,782...31,214,890
Ensembl chr12:31,194,859...31,216,802
JBrowse link
G Dhx9 DExH-box helicase 9 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DHX9 mRNA] CTD PMID:29095437 NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Metformin inhibits the reaction [Acetaminophen affects the localization of DIABLO protein] CTD PMID:27562556 NCBI chr12:33,055,784...33,070,400
Ensembl chr12:33,055,263...33,070,387
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase increases expression EXP Metformin results in increased expression of DLAT mRNA CTD PMID:31324951 NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
JBrowse link
G Dlgap5 DLG associated protein 5 increases expression EXP Metformin results in increased expression of DLGAP5 mRNA CTD PMID:25596134 NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 increases expression EXP Metformin results in increased expression of DMBT1 mRNA CTD PMID:31324951 NCBI chr 1:185,617,469...185,696,476 JBrowse link
G Dmxl2 Dmx-like 2 decreases expression EXP Metformin results in decreased expression of DMXL2 mRNA CTD PMID:31324951 NCBI chr 8:54,741,164...54,884,948
Ensembl chr 8:54,741,160...54,885,161
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression EXP Metformin results in increased expression of DNAJB9 mRNA CTD PMID:25596134 NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP Metformin inhibits the reaction [Glucose results in increased expression of DNM1L protein] CTD PMID:30144576 NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
JBrowse link
G Dnmbp dynamin binding protein decreases expression EXP Metformin results in decreased expression of DNMBP mRNA CTD PMID:25596134 NCBI chr 1:242,736,189...242,829,498
Ensembl chr 1:242,736,189...242,802,604
JBrowse link
G Dpep1 dipeptidase 1 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DPEP1 mRNA] CTD PMID:29095437 NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
JBrowse link
G Dpp9 dipeptidyl peptidase 9 decreases expression EXP Metformin results in decreased expression of DPP9 mRNA CTD PMID:25596134 NCBI chr 9:1,011,347...1,046,337
Ensembl chr 9:1,011,351...1,046,541
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Metformin results in decreased expression of DUSP1 mRNA CTD PMID:31324951 NCBI chr10:16,680,489...16,683,276 JBrowse link
G Dusp22 dual specificity phosphatase 22 decreases expression EXP Metformin results in decreased expression of DUSP22 mRNA CTD PMID:25596134 NCBI chr17:33,780,980...33,831,540
Ensembl chr17:33,780,981...33,831,321
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression EXP Metformin results in increased expression of DUSP4 mRNA CTD PMID:19664596 NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression EXP
ISO
Metformin results in increased expression of DUSP5 mRNA CTD PMID:25596134 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of E2F4 mRNA CTD PMID:29309887 NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Metformin results in increased expression of ECH1 mRNA CTD PMID:31324951 NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 increases expression EXP Metformin results in increased expression of ECI1 mRNA CTD PMID:31324951 NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression
multiple interactions
EXP
ISO
Metformin results in increased expression of EDA2R mRNA
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of EDA2R mRNA]
CTD PMID:25596134 PMID:29095437 NCBI chr  X:62,224,763...62,269,344
Ensembl chr  X:62,228,229...62,269,268
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP
ISO
Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]
Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]
CTD PMID:25108154 PMID:26497364 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
JBrowse link
G Efna1 ephrin A1 decreases expression EXP Metformin results in decreased expression of EFNA1 mRNA CTD PMID:25596134 NCBI chr 2:174,681,676...174,690,306
Ensembl chr 2:174,681,682...174,690,866
JBrowse link
G Egr1 early growth response 1 increases expression EXP Metformin results in increased expression of EGR1 mRNA CTD PMID:19664596 PMID:31324951 NCBI chr18:26,463,333...26,465,531
Ensembl chr18:26,462,981...26,466,766
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression EXP Metformin results in increased expression of EIF1 mRNA CTD PMID:25596134 NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta increases expression EXP Metformin results in increased expression of EIF2S2 mRNA CTD PMID:25596134 NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C increases expression EXP Metformin results in increased expression of EIF3C mRNA CTD PMID:25596134 NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E decreases expression
multiple interactions
ISO Metformin results in decreased expression of EIF4E mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of EIF4E mRNA
CTD PMID:32589349 NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
ISO Metformin results in decreased phosphorylation of EIF4EBP1 protein
Metformin decreases phosphorylation of EIF4EBP1 protein in epithelial cell of alveolus of lung
Metformin results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein
CTD
RGD
PMID:22108913 PMID:23363784 PMID:23632475 RGD:150404268 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Elf4 E74 like ETS transcription factor 4 increases expression EXP Metformin results in increased expression of ELF4 mRNA CTD PMID:25596134 NCBI chr  X:127,587,401...127,639,063
Ensembl chr  X:127,590,650...127,630,200
JBrowse link
G Elk4 ETS transcription factor ELK4 increases expression ISO Metformin results in increased expression of ELK4 mRNA CTD PMID:25596134 NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 decreases expression
affects expression
ISO
EXP
Metformin results in decreased expression of ELOVL6 protein
Metformin affects the expression of ELOVL6 mRNA
CTD PMID:28576465 PMID:31324951 NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
JBrowse link
G Emb embigin decreases expression EXP Metformin results in decreased expression of EMB mRNA CTD PMID:31324951 NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
JBrowse link
G Eno2 enolase 2 increases expression EXP Metformin results in increased expression of ENO2 mRNA CTD PMID:25596134 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 increases expression EXP Metformin results in increased expression of ENTPD7 mRNA CTD PMID:31324951 NCBI chr 1:242,559,365...242,601,044
Ensembl chr 1:242,559,365...242,601,447
JBrowse link
G Ep400 E1A binding protein p400 affects expression EXP Metformin affects the expression of EP400 mRNA CTD PMID:25596134 NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861
JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase increases expression EXP Metformin results in increased expression of EPRS mRNA CTD PMID:25596134 NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
JBrowse link
G Eqtn equatorin multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of EQTN mRNA] CTD PMID:29095437 NCBI chr 5:109,734,495...109,762,048
Ensembl chr 5:109,728,999...109,761,840
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression EXP Metformin results in decreased expression of ERBB3 mRNA CTD PMID:31324951 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO
EXP
Metformin binds to and results in decreased activity of ESR1 protein; Metformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]]
Metformin inhibits the reaction [Testosterone results in increased expression of ESR1 mRNA]
CTD PMID:22132214 PMID:26492952 PMID:33049310 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP Metformin inhibits the reaction [Testosterone results in decreased expression of ESR2 mRNA] CTD PMID:26492952 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
decreases expression
ISO Metformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA]
Metformin results in decreased expression of ESRRA mRNA
CTD PMID:23166782 NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
JBrowse link
G Faap20 FA core complex associated protein 20 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of FAAP20 mRNA] CTD PMID:29095437 NCBI chr 5:165,808,370...165,815,291
Ensembl chr 5:165,808,657...165,815,333
JBrowse link
G Fabp2 fatty acid binding protein 2 decreases expression EXP Metformin results in decreased expression of FABP2 mRNA CTD PMID:19022234 NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Metformin results in increased expression of FABP3 mRNA CTD PMID:25596134 NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
JBrowse link
G Fabp7 fatty acid binding protein 7 increases expression EXP Metformin results in increased expression of FABP7 mRNA CTD PMID:31324951 NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
JBrowse link
G Fam149a family with sequence similarity 149, member A decreases expression EXP Metformin results in decreased expression of FAM149A mRNA CTD PMID:31324951 NCBI chr16:46,855,377...46,914,553
Ensembl chr16:46,854,635...46,912,066
JBrowse link
G Fam210a family with sequence similarity 210, member A increases expression EXP Metformin results in increased expression of FAM210A mRNA CTD PMID:25596134 NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171
JBrowse link
G Fam214a family with sequence similarity 214, member A decreases expression EXP Metformin results in decreased expression of FAM214A mRNA CTD PMID:25596134 NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549
JBrowse link
G Fam32a family with sequence similarity 32, member A decreases expression EXP Metformin results in decreased expression of FAM32A mRNA CTD PMID:25596134 NCBI chr16:17,603,054...17,607,376
Ensembl chr16:17,603,946...17,607,398
JBrowse link
G Fas Fas cell surface death receptor affects expression EXP Metformin affects the expression of FAS mRNA CTD PMID:25596134 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
JBrowse link
G Fasn fatty acid synthase decreases expression
increases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of FASN mRNA
Metformin results in increased expression of FASN mRNA
[Metformin co-treated with caffeic acid] results in decreased expression of FASN protein
CTD PMID:20956498 PMID:21870829 PMID:28576465 PMID:31324951 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression EXP Metformin results in decreased expression of FBP1 mRNA CTD PMID:19022234 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
JBrowse link
G Fbxo22 F-box protein 22 increases expression EXP Metformin results in increased expression of FBXO22 mRNA CTD PMID:25596134 NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
JBrowse link
G Fbxo30 F-box protein 30 increases expression EXP Metformin results in increased expression of FBXO30 mRNA CTD PMID:25596134 NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441
JBrowse link
G Fbxo32 F-box protein 32 decreases expression EXP Metformin results in decreased expression of FBXO32 mRNA CTD PMID:31324951 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Fech ferrochelatase decreases expression EXP Metformin results in decreased expression of FECH mRNA CTD PMID:25596134 NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA] CTD PMID:26497364 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fgf19 fibroblast growth factor 19 multiple interactions ISO [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of FGF15 mRNA CTD PMID:34058177 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases expression EXP Metformin results in decreased expression of FGR mRNA CTD PMID:25596134 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
JBrowse link
G Ficd FIC domain protein adenylyltransferase increases expression EXP Metformin results in increased expression of FICD mRNA CTD PMID:31324951 NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP Metformin inhibits the reaction [Glucose results in increased expression of FIS1 protein] CTD PMID:30144576 NCBI chr12:19,708,558...19,723,392
Ensembl chr12:19,708,558...19,723,377
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of FKBP1A mRNA CTD PMID:29309887 NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
JBrowse link
G Flvcr2 FLVCR heme transporter 2 increases expression EXP Metformin results in increased expression of FLVCR2 mRNA CTD PMID:25596134 PMID:31324951 NCBI chr 6:105,408,355...105,472,355
Ensembl chr 6:105,408,339...105,472,353
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 decreases expression EXP Metformin results in decreased expression of FMO3 mRNA CTD PMID:31324951 NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO
Metformin inhibits the reaction [Dietary Fats results in increased expression of FN1 protein]
Metformin inhibits the reaction [Folic Acid results in increased expression of FN1 mRNA]; Metformin inhibits the reaction [Folic Acid results in increased expression of FN1 protein]
CTD PMID:27551045 PMID:29380373 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO
EXP
Metformin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of FOS protein]
Metformin results in decreased expression of FOS mRNA
CTD PMID:20590612 PMID:31324951 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
JBrowse link
G Foxa2 forkhead box A2 multiple interactions ISO [Metformin co-treated with Glucose] affects the localization of FOXA2 protein CTD PMID:16489446 NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
JBrowse link
G Foxo1 forkhead box O1 decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of FOXO1 mRNA
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]
CTD PMID:24428821 PMID:27270450 NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
JBrowse link
G Foxo3 forkhead box O3 decreases expression EXP Metformin results in decreased expression of FOXO3 mRNA CTD PMID:31324951 NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Metformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CCNE1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CYP19A1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]; Metformin inhibits the reaction [FSHB protein results in increased secretion of Estradiol]; Metformin inhibits the reaction [FSHB protein results in increased secretion of Progesterone]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSHB protein results in increased phosphorylation of PRKAA1 protein]] CTD PMID:16760380 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
JBrowse link
G Fut4 fucosyltransferase 4 increases expression ISO Metformin results in increased expression of FUT4 protein CTD PMID:26036281 NCBI chr 8:11,586,721...11,590,682
Ensembl chr 8:11,586,721...11,590,682
JBrowse link
G G0s2 G0/G1switch 2 increases expression EXP Metformin results in increased expression of G0S2 mRNA CTD PMID:31324951 NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
JBrowse link
G G6pc1 glucose-6-phosphatase catalytic subunit 1 multiple interactions
decreases expression
EXP
ISO
Metformin inhibits the reaction [Glucose results in increased expression of G6PC1 mRNA]
Metformin inhibits the reaction [INS protein results in increased expression of G6PC1 protein]
Metformin results in decreased expression of G6PC mRNA
Metformin results in decreased expression of G6PC1 mRNA
CTD PMID:19576170 PMID:19664596 PMID:24428821 PMID:31324951 PMID:31974165 More... NCBI chr10:86,307,400...86,318,766 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression EXP Metformin results in increased expression of G6PD mRNA CTD PMID:31324951 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO
EXP
Metformin results in increased expression of GADD45A mRNA CTD PMID:19022234 PMID:25596134 NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
JBrowse link
G Gars1 glycyl-tRNA synthetase 1 increases expression EXP Metformin results in increased expression of GARS mRNA CTD PMID:25596134 NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
JBrowse link
G Gbe1 1,4-alpha-glucan branching enzyme 1 increases expression EXP Metformin results in increased expression of GBE1 mRNA CTD PMID:25596134 NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression EXP Metformin results in decreased expression of GBP1 mRNA CTD PMID:31324951 NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,517,398...231,529,600
JBrowse link
G Gcg glucagon multiple interactions EXP
ISO
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]; Metformin inhibits the reaction [GCG results in increased abundance of Glucose]
[Metformin co-treated with GCG] results in increased expression of IL1RN mRNA; Metformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]; Metformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA]
CTD PMID:19002567 PMID:22117073 PMID:23166782 PMID:27270450 NCBI chr 3:47,113,914...47,122,929
Ensembl chr 3:47,113,914...47,122,929
JBrowse link
G Gck glucokinase affects expression
multiple interactions
EXP
ISO
Metformin affects the expression of GCK mRNA
Metformin inhibits the reaction [INS protein results in decreased activity of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GCK protein]
Metformin inhibits the reaction [Glucose results in decreased expression of GCK mRNA]
CTD PMID:31324951 PMID:31974165 PMID:33651899 NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
JBrowse link
G Gckr glucokinase regulator multiple interactions ISO Metformin inhibits the reaction [INS protein results in increased expression of GCKR protein] CTD PMID:33651899 NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP Metformin results in increased expression of GCLC mRNA CTD PMID:25596134 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases expression
increases expression
EXP
ISO
Metformin results in decreased expression of GCLM mRNA
Metformin results in increased expression of GCLM mRNA
CTD PMID:25596134 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression
multiple interactions
ISO
EXP
Metformin results in increased expression of GCNT3 mRNA
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of GCNT3 mRNA]
CTD PMID:25596134 PMID:29095437 NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression EXP Metformin results in increased expression of GDF15 mRNA CTD PMID:25596134 NCBI chr16:18,805,312...18,807,893
Ensembl chr16:18,805,239...18,808,055
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] CTD PMID:32652086 NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of GHRL protein] CTD PMID:32652086 NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
JBrowse link
G Ghsr growth hormone secretagogue receptor multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA] CTD PMID:32652086 NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
JBrowse link
G Gimd1 GIMAP family P-loop NTPase domain containing 1 increases expression EXP Metformin results in increased expression of GIMD1 mRNA CTD PMID:31324951 NCBI chr 2:221,103,878...221,138,559
Ensembl chr 2:221,103,878...221,138,553
JBrowse link
G Gls glutaminase decreases expression ISO Metformin results in decreased expression of GLS protein CTD PMID:28576465 NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B increases expression EXP Metformin results in increased expression of GMPPB mRNA CTD PMID:31324951 NCBI chr 8:108,737,429...108,767,286
Ensembl chr 8:108,693,060...108,767,286
JBrowse link
G Gmpr guanosine monophosphate reductase decreases expression ISO Metformin results in decreased expression of GMPR mRNA CTD PMID:23457588 NCBI chr17:19,151,820...19,189,626
Ensembl chr17:19,151,815...19,189,621
JBrowse link
G Gnmt glycine N-methyltransferase decreases expression EXP Metformin results in decreased expression of GNMT mRNA CTD PMID:31324951 NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
JBrowse link
G Golph3l golgi phosphoprotein 3-like increases expression EXP Metformin results in increased expression of GOLPH3L mRNA CTD PMID:31324951 NCBI chr 2:183,151,941...183,183,094
Ensembl chr 2:183,153,301...183,183,083
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression EXP Metformin results in decreased expression of GOT1 mRNA CTD PMID:25596134 PMID:31324951 NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression EXP Metformin results in increased expression of GPAM mRNA CTD PMID:31324951 NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Metformin results in increased expression of GPAT3 mRNA CTD PMID:25596134 NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
JBrowse link
G Gphn gephyrin increases expression EXP Metformin results in increased expression of GPHN mRNA CTD PMID:25596134 NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
JBrowse link
G Gpihbp1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 increases expression EXP Metformin results in increased expression of GPIHBP1 mRNA CTD PMID:31324951 NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Metformin results in increased expression of GPNMB mRNA CTD PMID:25596134 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Gpr22 G protein-coupled receptor 22 decreases expression EXP Metformin results in decreased expression of GPR22 mRNA CTD PMID:31324951 NCBI chr 6:48,309,619...48,317,864
Ensembl chr 6:48,310,505...48,317,486
JBrowse link
G Gprin3 GPRIN family member 3 increases expression EXP Metformin results in increased expression of GPRIN3 mRNA CTD PMID:31324951 NCBI chr 4:88,563,708...88,657,603
Ensembl chr 4:88,563,607...88,657,429
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP
Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein]; Metformin inhibits the reaction [Acetaminophen results in increased expression of and results in increased secretion of and results in increased activity of GPT protein]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased activity of GPT protein]
CTD PMID:24717679 PMID:27562556 PMID:29614383 PMID:31743741 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gsk3a glycogen synthase kinase 3 alpha increases phosphorylation ISO Metformin results in increased phosphorylation of GSK3A protein CTD PMID:26835874 NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO
EXP
Metformin results in increased phosphorylation of GSK3B protein
Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [Methamphetamine results in increased expression of and results in increased phosphorylation of GSK3B protein]
Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in increased expression of GSK3B protein]
CTD PMID:21054339 PMID:26835874 PMID:30742852 PMID:30928401 PMID:31877369 More... NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
JBrowse link
G Gsn gelsolin increases expression ISO Metformin results in increased expression of GSN mRNA CTD PMID:19022234 NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
JBrowse link
G Gspt1 G1 to S phase transition 1 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of GSPT1 mRNA] CTD PMID:29095437 NCBI chr10:4,362,528...4,397,215
Ensembl chr10:4,362,510...4,397,198
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
affects expression
ISO
EXP
Metformin inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein]
Metformin inhibits the reaction [Methamphetamine results in decreased activity of GSR protein]
Metformin affects the expression of GSR mRNA
CTD PMID:24717679 PMID:25596134 PMID:30742852 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Metformin inhibits the reaction [Doxorubicin results in increased expression of GSTA1 mRNA] CTD PMID:22666520 NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Metformin results in decreased expression of GSTM2 mRNA CTD PMID:31324951 NCBI chr 2:195,624,015...195,628,774 JBrowse link
G Gstm7 glutathione S-transferase, mu 7 decreases expression EXP Metformin results in decreased expression of GSTM7 mRNA CTD PMID:31324951 NCBI chr 2:195,566,701...195,572,149
Ensembl chr 2:195,566,701...195,572,203
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Metformin results in increased expression of GSTP1 mRNA CTD PMID:19022234 NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
JBrowse link
G Gypa glycophorin A decreases expression EXP Metformin results in decreased expression of GYPA mRNA CTD PMID:31324951 NCBI chr19:27,450,311...27,465,940 JBrowse link
G Gys1 glycogen synthase 1 multiple interactions ISO Metformin inhibits the reaction [INS protein results in decreased expression of GYS1 protein] CTD PMID:33651899 NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292
JBrowse link
G H1f2 H1.2 linker histone, cluster member decreases expression ISO Metformin results in decreased expression of H1-2 mRNA CTD PMID:25596134 NCBI chr17:41,391,106...41,392,611 JBrowse link
G H2ax H2A.X variant histone decreases expression
increases expression
multiple interactions
ISO Metformin results in decreased expression of H2AX protein
Metformin results in increased expression of H2AX mRNA
[epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA
CTD PMID:23363784 PMID:29117515 NCBI chr 8:44,671,927...44,673,257
Ensembl chr 8:44,671,786...44,673,239
JBrowse link
G Hal histidine ammonia lyase decreases expression EXP Metformin results in decreased expression of HAL mRNA CTD PMID:31324951 NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression EXP Metformin results in decreased expression of HAMP mRNA CTD PMID:31324951 NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]] CTD PMID:30551545 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
JBrowse link
G Hbb hemoglobin subunit beta decreases expression EXP Metformin results in decreased expression of HBB-B1 mRNA CTD PMID:31324951 NCBI chr 1:158,250,421...158,251,832 JBrowse link
G Hbb-bs hemoglobin, beta adult s chain decreases expression EXP Metformin results in decreased expression of HBB-BS mRNA CTD PMID:31324951 NCBI chr 1:158,218,356...158,219,722 JBrowse link
G Heatr6 HEAT repeat containing 6 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HEATR6 mRNA] CTD PMID:29095437 NCBI chr10:68,634,855...68,665,445
Ensembl chr10:68,635,065...68,664,105
JBrowse link
G Hemgn hemogen decreases expression EXP Metformin results in decreased expression of HEMGN mRNA CTD PMID:31324951 NCBI chr 5:60,679,633...60,698,597
Ensembl chr 5:60,679,633...60,698,669
JBrowse link
G Herc3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 decreases expression EXP Metformin results in decreased expression of HERC3 mRNA CTD PMID:25596134 NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression EXP Metformin results in increased expression of HERPUD1 mRNA CTD PMID:31324951 NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
JBrowse link
G Hhex hematopoietically expressed homeobox decreases expression EXP Metformin results in decreased expression of HHEX mRNA CTD PMID:31324951 NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects activity
multiple interactions
decreases expression
EXP
ISO
Metformin affects the activity of HIF1A protein
[Metformin co-treated with Pioglitazone] results in decreased expression of HIF1A mRNA
Metformin results in decreased expression of HIF1A mRNA
CTD PMID:25596134 PMID:32589349 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hist2h3c2 histone cluster 2 H3 family member C2 increases expression EXP Metformin results in increased expression of HIST2H3C2 mRNA CTD PMID:31324951 NCBI chr 2:183,837,311...183,837,721
Ensembl chr 2:183,837,303...183,837,752
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO [Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein] CTD PMID:25412314 NCBI chr12:5,973,062...5,978,565 JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression
increases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of HMGCR mRNA
Metformin results in increased expression of HMGCR mRNA
Metformin inhibits the reaction [AGT protein results in increased activity of and results in increased phosphorylation of HMGCR protein]
CTD PMID:21870829 PMID:29499335 PMID:31324951 NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases expression
multiple interactions
decreases response to substance
ISO
EXP
Metformin results in increased expression of HMOX1 mRNA
Metformin results in decreased expression of HMOX1 mRNA; Metformin results in decreased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Metformin results in decreased expression of HMOX1 protein]
HMOX1 protein results in decreased susceptibility to Metformin
Metformin inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA]
CTD PMID:19022234 PMID:21457706 PMID:22666520 PMID:23707609 PMID:25596134 More... NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression EXP
ISO
Metformin results in decreased expression of HNF4A mRNA
Metformin results in decreased expression of HNF4A mRNA; Metformin results in decreased expression of HNF4A protein
CTD PMID:19022234 PMID:24428821 NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of HNRNPK mRNA CTD PMID:29309887 NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
JBrowse link
G Hook2 hook microtubule-tethering protein 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HOOK2 mRNA] CTD PMID:29095437 NCBI chr19:23,151,869...23,170,139
Ensembl chr19:23,151,870...23,164,181
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of HRAS mRNA CTD PMID:29309887 NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO [Cimetidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Ranitidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin CTD PMID:16632449 NCBI chr17:10,368,355...10,407,791
Ensembl chr17:10,368,298...10,407,631
JBrowse link
G Hsc70-ps1 heat shock cognate protein 70, pseudogene 1 increases expression EXP Metformin results in increased expression of HSC70-PS1 mRNA CTD PMID:31324951 NCBI chr 2:164,044,226...164,046,344 JBrowse link
G Hsc70-ps2 heat shock cognate protein 70, pseudogene 2 increases expression EXP Metformin results in increased expression of HSC70-PS2 mRNA CTD PMID:31324951 NCBI chr18:16,210,467...16,212,736 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions
EXP
ISO
Metformin results in increased expression of HSPA5 mRNA
Metformin inhibits the reaction [Rotenone results in increased expression of HSPA5 mRNA]
CTD PMID:25596134 PMID:32189544 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression EXP Metformin results in increased expression of HSPH1 mRNA CTD PMID:31324951 NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression EXP Metformin results in increased expression of HTATIP2 mRNA CTD PMID:25596134 NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
JBrowse link
G Hykk hydroxylysine kinase decreases expression EXP Metformin results in decreased expression of HYKK mRNA CTD PMID:31324951 NCBI chr 8:55,315,919...55,339,720
Ensembl chr 8:55,315,969...55,337,339
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression EXP Metformin results in increased expression of HYOU1 mRNA CTD PMID:31324951 NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 increases expression EXP Metformin results in increased expression of IARS mRNA; Metformin results in increased expression of IARS1 mRNA CTD PMID:25596134 PMID:31324951 NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Metformin inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form] CTD PMID:25108154 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP Metformin results in increased expression of IDI1 mRNA CTD PMID:31324951 NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression EXP Metformin results in decreased expression of IFITM3 mRNA CTD PMID:31324951 NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
ISO Metformin results in increased expression of IFNG protein
[Paclitaxel co-treated with Metformin] results in increased expression of IFNG mRNA
CTD PMID:20869956 PMID:29309887 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO
EXP
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with Pioglitazone] results in decreased expression of IGF1 mRNA
Metformin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA]
Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]
CTD PMID:21664031 PMID:23927877 PMID:26492952 PMID:26497364 PMID:32589349 NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO
EXP
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNA
Metformin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]
CTD PMID:21664031 PMID:26492952 NCBI chr 1:121,549,839...121,838,545
Ensembl chr 1:121,550,743...121,831,777
JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions ISO [Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 protein CTD PMID:21664031 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
JBrowse link
G Igf2r insulin-like growth factor 2 receptor multiple interactions
increases expression
ISO
EXP
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF2R mRNA
Metformin results in increased expression of IGF2R mRNA
CTD PMID:21664031 PMID:25596134 NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 decreases expression ISO
EXP
Metformin results in decreased expression of IGFBP1 mRNA CTD PMID:21316309 PMID:31324951 NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of IKBKB mRNA CTD PMID:29309887 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Il10 interleukin 10 multiple interactions EXP Metformin inhibits the reaction [Streptozocin results in decreased expression of IL10 protein] CTD PMID:33639173 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of ARG1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL24 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL7 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CHIL3 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CXCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MGL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP9 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]; Metformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of RETNLA mRNA] CTD PMID:26497364 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il15ra interleukin 15 receptor subunit alpha multiple interactions
decreases expression
ISO [Metformin co-treated with Cyclic AMP] results in decreased expression of IL15RA mRNA; Metformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA]
Metformin results in decreased expression of IL15RA mRNA
CTD PMID:22117073 NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278
JBrowse link
G Il17rb interleukin 17 receptor B decreases expression EXP Metformin results in decreased expression of IL17RB mRNA CTD PMID:25596134 NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK10 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK9 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Metformin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]; Metformin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Metformin inhibits the reaction [Methamphetamine results in increased expression of IL1B protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]
Metformin inhibits the reaction [IL13 protein results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
Metformin results in increased expression of IL1B mRNA
CTD PMID:16385087 PMID:21316309 PMID:26497364 PMID:27551045 PMID:27634381 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions
increases expression
ISO [Metformin co-treated with GCG] results in increased expression of IL1RN mRNA; Cyclic AMP promotes the reaction [Metformin results in increased expression of IL1RN mRNA]; Metformin promotes the reaction [Cyclic AMP results in increased expression of IL1RN mRNA] CTD PMID:22117073 NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
JBrowse link
G Il33 interleukin 33 decreases expression EXP Metformin results in decreased expression of IL33 mRNA CTD PMID:31324951 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
increases expression
ISO
EXP
Metformin results in decreased expression of IL6 mRNA
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]; Metformin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL6 protein]
3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; Metformin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of IL6 protein]
Metformin results in increased expression of IL6 mRNA; Metformin results in increased expression of IL6 protein
Metformin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]
CTD PMID:16385087 PMID:20869956 PMID:20956498 PMID:21457706 PMID:21870829 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression EXP Metformin results in decreased expression of INMT mRNA CTD PMID:31324951 NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
JBrowse link
G Ins2 insulin 2 multiple interactions
increases expression
decreases expression
ISO [Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in increased phosphorylation of AKT1 protein; Metformin inhibits the reaction [[Glucose affects the susceptibility to INS protein] which affects the uptake of Glucose]; Metformin inhibits the reaction [INS protein results in decreased activity of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of BAD protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GYS1 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of G6PC1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of GCKR protein]; Metformin inhibits the reaction [INS protein results in increased expression of GSK3B protein]; Metformin inhibits the reaction [INS protein results in increased expression of PTPN1 protein]; Metformin promotes the reaction [Glucose results in increased secretion of INS protein]; Metformin results in decreased expression of and results in decreased secretion of INS protein; Metformin results in increased expression of and results in increased secretion of INS protein
Metformin results in increased expression of INS mRNA
Metformin results in decreased expression of INS protein
CTD PMID:1900072 PMID:15531508 PMID:18082302 PMID:21664031 PMID:21779873 More... NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Metformin results in increased expression of INSIG1 mRNA CTD PMID:23457588 NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
JBrowse link
G Insig2 insulin induced gene 2 decreases expression EXP Metformin results in decreased expression of INSIG2 mRNA CTD PMID:25596134 NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
JBrowse link
G Insr insulin receptor multiple interactions
increases phosphorylation
ISO [Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNA
Metformin results in increased phosphorylation of INSR protein
Metformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]
CTD PMID:21664031 PMID:23927877 PMID:26835874 NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
JBrowse link
G Irf2bp2 interferon regulatory factor 2 binding protein 2 decreases expression EXP Metformin results in decreased expression of IRF2BP2 mRNA CTD PMID:31324951 NCBI chr19:54,559,409...54,564,714 JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of IRF3 mRNA CTD PMID:29309887 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Irf5 interferon regulatory factor 5 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of IRF5 mRNA CTD PMID:29309887 NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of IRF7 mRNA CTD PMID:29309887 NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO
EXP
Metformin affects the reaction [Testosterone results in decreased expression of IRS1]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]
Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]
Metformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]; Metformin promotes the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of IRS1 protein]
CTD PMID:19328476 PMID:23927877 PMID:27634381 PMID:30914352 PMID:30928401 More... NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression EXP Metformin results in decreased expression of IRS2 mRNA CTD PMID:31324951 NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
JBrowse link
G Iscu iron-sulfur cluster assembly enzyme affects expression EXP Metformin affects the expression of ISCU mRNA CTD PMID:25596134 NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150
JBrowse link
G Itgb1 integrin subunit beta 1 increases expression EXP Metformin results in increased expression of ITGB1 mRNA CTD PMID:25596134 NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
JBrowse link
G Itgb8 integrin subunit beta 8 increases expression EXP Metformin results in increased expression of ITGB8 mRNA CTD PMID:31324951 NCBI chr 6:140,124,997...140,208,254
Ensembl chr 6:140,127,203...140,208,476
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ITPR2 mRNA] CTD PMID:29095437 NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
JBrowse link
G Jkamp JNK1/MAPK8-associated membrane protein multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of JKAMP mRNA] CTD PMID:29095437 NCBI chr 6:90,648,043...90,661,985
Ensembl chr 6:90,648,160...90,662,501
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Metformin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein] CTD PMID:20590612 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Metformin results in decreased expression of JUNB mRNA CTD PMID:31324951 NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Metformin results in increased expression of JUND mRNA CTD PMID:19022234 NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
JBrowse link
G Kbtbd12 kelch repeat and BTB domain containing 12 increases expression EXP Metformin results in increased expression of KBTBD12 mRNA CTD PMID:31324951 NCBI chr 4:121,014,636...121,088,701
Ensembl chr 4:121,016,257...121,088,443
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression
multiple interactions
EXP Metformin results in decreased expression of KEAP1 mRNA
Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein]
CTD PMID:25596134 PMID:33639173 NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
JBrowse link
G Klf15 Kruppel-like factor 15 decreases expression ISO Metformin results in decreased expression of KLF15 mRNA CTD PMID:24428821 NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression EXP Metformin results in decreased expression of KLF9 mRNA CTD PMID:31324951 NCBI chr 1:220,700,108...220,725,029
Ensembl chr 1:220,700,108...220,725,037
JBrowse link
G Klhl33 kelch-like family member 33 decreases expression EXP Metformin results in decreased expression of KLHL33 mRNA CTD PMID:31324951 NCBI chr15:24,105,923...24,114,445
Ensembl chr15:24,105,930...24,114,438
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of KRAS mRNA CTD PMID:29309887 NCBI chr 4:178,185,418...178,218,484 JBrowse link
G Krt19 keratin 19 increases expression EXP Metformin results in increased expression of KRT19 mRNA CTD PMID:25596134 NCBI chr10:85,075,835...85,080,552 JBrowse link
G Krt80 keratin 80 increases expression ISO Metformin results in increased expression of KRT80 mRNA CTD PMID:21527772 NCBI chr 7:132,464,807...132,485,026
Ensembl chr 7:132,463,218...132,485,508
JBrowse link
G Lamc2 laminin subunit gamma 2 decreases expression EXP Metformin results in decreased expression of LAMC2 mRNA CTD PMID:31324951 NCBI chr13:65,284,664...65,344,200
Ensembl chr13:65,284,664...65,344,200
JBrowse link
G Lars1 leucyl-tRNA synthetase 1 increases expression EXP Metformin results in increased expression of LARS mRNA CTD PMID:25596134 NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
JBrowse link
G Lce1d late cornified envelope 1D multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of LCE1D mRNA] CTD PMID:29095437
G Lcn2 lipocalin 2 multiple interactions EXP Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein] CTD PMID:30551545 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of LDLR protein]
Metformin inhibits the reaction [AGT protein results in increased expression of LDLR protein]; Metformin inhibits the reaction [Hydrogen Peroxide results in increased expression of LDLR protein]
CTD PMID:29499335 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lep leptin increases expression
multiple interactions
ISO Metformin results in increased expression of LEP protein
Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein]
CTD PMID:20869956 PMID:32652086 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lgals5 galectin 5 decreases expression EXP Metformin results in decreased expression of LGALS5 mRNA CTD PMID:31324951 NCBI chr10:63,853,949...63,857,198
Ensembl chr10:63,853,935...63,857,153
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Metformin inhibits the reaction [Letrozole results in increased secretion of LHB protein] CTD PMID:32298659 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972
JBrowse link
G Lingo3 leucine rich repeat and Ig domain containing 3 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of LINGO3 mRNA CTD PMID:29309887 NCBI chr 7:8,869,025...8,878,431
Ensembl chr 7:8,869,025...8,878,431
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 decreases expression EXP Metformin results in decreased expression of LMCD1 mRNA CTD PMID:25596134 NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
JBrowse link
G Lmna lamin A/C multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of LMNA mRNA] CTD PMID:29095437 NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
JBrowse link
G Lox lysyl oxidase affects expression EXP Metformin affects the expression of LOX mRNA CTD PMID:31324951 NCBI chr18:45,964,311...46,041,477
Ensembl chr18:45,967,343...46,041,477
JBrowse link
G Lpar3 lysophosphatidic acid receptor 3 decreases expression EXP Metformin results in decreased expression of LPAR3 mRNA CTD PMID:31324951 NCBI chr 2:235,125,234...235,193,916
Ensembl chr 2:235,149,065...235,193,357
JBrowse link
G Lpin2 lipin 2 decreases expression EXP Metformin results in decreased expression of LPIN2 mRNA CTD PMID:31324951 NCBI chr 9:111,083,378...111,158,193
Ensembl chr 9:111,083,745...111,158,193
JBrowse link
G Lss lanosterol synthase increases expression EXP Metformin results in increased expression of LSS mRNA CTD PMID:31324951 NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression EXP Metformin results in decreased expression of LTN1 mRNA CTD PMID:25596134 NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886
JBrowse link
G Lurap1l leucine rich adaptor protein 1-like decreases expression EXP Metformin results in decreased expression of LURAP1L mRNA CTD PMID:31324951 NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438
JBrowse link
G Lyst lysosomal trafficking regulator decreases expression EXP Metformin results in decreased expression of LYST mRNA CTD PMID:31324951 NCBI chr17:86,241,384...86,443,501 JBrowse link
G Mafg MAF bZIP transcription factor G increases expression EXP Metformin results in increased expression of MAFG mRNA CTD PMID:25596134 NCBI chr10:105,903,307...105,911,845
Ensembl chr10:105,903,237...105,912,026
JBrowse link
G Magohb mago homolog B, exon junction complex subunit increases expression EXP Metformin results in increased expression of MAGOHB mRNA CTD PMID:31324951 NCBI chr 4:165,034,131...165,041,977
Ensembl chr 4:165,034,122...165,041,967
JBrowse link
G Man1a2 mannosidase, alpha, class 1A, member 2 increases expression EXP Metformin results in increased expression of MAN1A2 mRNA CTD PMID:25596134 NCBI chr 2:187,947,484...188,096,332
Ensembl chr 2:187,951,617...188,096,332
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form] CTD PMID:25412314 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of MAP2K3 mRNA CTD PMID:29309887 NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
JBrowse link
G Map3k2 mitogen activated protein kinase kinase kinase 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K2 mRNA CTD PMID:29309887 NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K7 mRNA CTD PMID:29309887 NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
JBrowse link
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of MAP4K2 mRNA] CTD PMID:29095437 NCBI chr 1:203,645,098...203,660,515
Ensembl chr 1:203,645,153...203,660,331
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Metformin results in decreased phosphorylation of MAPK1 protein
Metformin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein]
CTD PMID:16385087 PMID:16760380 PMID:20590612 PMID:23707609 PMID:33639173 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions ISO Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK10 protein] CTD PMID:16385087 NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of MAPK14 mRNA CTD PMID:29309887 NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Metformin results in decreased phosphorylation of MAPK3 protein
Metformin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein]
CTD PMID:16385087 PMID:16760380 PMID:20590612 PMID:23707609 PMID:33639173 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK9 protein] CTD PMID:16385087 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor increases expression EXP Metformin results in increased expression of MCM10 mRNA CTD PMID:31324951 NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364
JBrowse link
G Mctp2 multiple C2 and transmembrane domain containing 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MCTP2 mRNA] CTD PMID:29095437 NCBI chr 1:125,769,932...126,002,886
Ensembl chr 1:125,771,233...126,002,928
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP Metformin results in increased expression of MDM2 mRNA CTD PMID:25596134 NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
JBrowse link
G Me1 malic enzyme 1 increases expression
decreases expression
EXP
ISO
Metformin results in increased expression of ME1 mRNA
Metformin results in decreased expression of ME1 protein
CTD PMID:25596134 PMID:28576465 PMID:31324951 NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
JBrowse link
G Med29 mediator complex subunit 29 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MED29 mRNA] CTD PMID:29095437 NCBI chr 1:83,677,961...83,683,365
Ensembl chr 1:83,677,961...83,683,365
JBrowse link
G Mef2a myocyte enhancer factor 2a increases expression ISO Metformin results in increased expression of MEF2A mRNA CTD PMID:15864539 NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
JBrowse link
G Mef2c myocyte enhancer factor 2C increases expression ISO Metformin results in increased expression of MEF2C mRNA CTD PMID:15864539 NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
JBrowse link
G Mef2d myocyte enhancer factor 2D increases expression ISO Metformin results in increased expression of MEF2D mRNA CTD PMID:15864539 NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457
JBrowse link
G Mettl1 methyltransferase like 1 increases expression EXP Metformin results in increased expression of METTL1 mRNA CTD PMID:31324951 NCBI chr 7:62,864,816...62,869,202
Ensembl chr 7:62,864,853...62,869,202
JBrowse link
G Mettl22 methyltransferase like 22 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of METTL22 mRNA] CTD PMID:29095437 NCBI chr10:7,113,602...7,130,715
Ensembl chr10:7,113,660...7,130,654
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP Metformin inhibits the reaction [Glucose results in decreased expression of MFN2 protein] CTD PMID:30144576 NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A affects expression EXP Metformin affects the expression of MFSD2A mRNA CTD PMID:31324951 NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
JBrowse link
G Mgat2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase increases expression EXP Metformin results in increased expression of MGAT2 mRNA CTD PMID:31324951 NCBI chr 6:87,656,360...87,658,849
Ensembl chr 6:87,656,349...87,658,177
JBrowse link
G Mid1ip1 MID1 interacting protein 1 increases expression EXP Metformin results in increased expression of MID1IP1 mRNA CTD PMID:31324951 NCBI chr  X:12,060,993...12,063,318
Ensembl chr  X:12,060,883...12,065,774
JBrowse link
G Mir1 microRNA 1 increases expression EXP Metformin results in increased expression of MIR1 mRNA CTD PMID:31324951 NCBI chr18:1,887,537...1,887,623 JBrowse link
G Mir146a microRNA 146a multiple interactions EXP Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of MIR146A mRNA] CTD PMID:30290168 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
JBrowse link
G Mir155 microRNA 155 multiple interactions EXP Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in increased expression of MIR155 mRNA] CTD PMID:30290168 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir15b microRNA 15b increases expression EXP Metformin results in increased expression of MIR15B mRNA CTD PMID:31324951 NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
JBrowse link
G Mir190 microRNA 190 decreases expression EXP Metformin results in decreased expression of MIR190 mRNA CTD PMID:31324951 NCBI chr 8:67,850,987...67,851,071 JBrowse link
G Mir19a microRNA 19a multiple interactions ISO Metformin inhibits the reaction [Oxygen deficiency results in decreased expression of MIR19A mRNA] CTD PMID:33476677 NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
JBrowse link
G Mir290 microRNA 290 decreases expression EXP Metformin results in decreased expression of MIR292 mRNA CTD PMID:31324951 NCBI chr 1:65,964,648...65,964,728
Ensembl chr 1:65,964,648...65,964,728
JBrowse link
G Mir29b2 microRNA 29b-2 decreases expression EXP Metformin results in decreased expression of MIR29B2 mRNA CTD PMID:31324951 NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456
JBrowse link
G Mir99b microRNA 99b multiple interactions EXP Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of MIR99B mRNA] CTD PMID:30290168 NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090
JBrowse link
G Mme membrane metallo-endopeptidase decreases expression EXP Metformin results in decreased expression of MME mRNA CTD PMID:31324951 NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
JBrowse link
G Mmp10 matrix metallopeptidase 10 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA] CTD PMID:26497364 NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA] CTD PMID:26497364 NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
JBrowse link
G Mmp19 matrix metallopeptidase 19 increases expression EXP Metformin results in increased expression of MMP19 mRNA CTD PMID:25596134 NCBI chr 7:1,221,229...1,229,555
Ensembl chr 7:1,221,343...1,229,555
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
decreases activity
ISO Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]
Metformin results in decreased expression of MMP2 mRNA
Metformin results in decreased activity of MMP2 protein
CTD PMID:20590612 PMID:22246099 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity
ISO Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
Metformin inhibits the reaction [IL13 protein results in increased expression of MMP9 mRNA]
Metformin results in decreased expression of MMP9 mRNA
Metformin results in decreased activity of MMP9 protein
CTD PMID:20590612 PMID:22246099 PMID:26497364 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mocos molybdenum cofactor sulfurase decreases expression EXP Metformin results in decreased expression of MOCOS mRNA CTD PMID:31324951 NCBI chr18:15,931,654...15,977,415
Ensembl chr18:15,931,654...15,977,187
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Metformin inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein] CTD PMID:24717679 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 protein] CTD PMID:26497364 NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
JBrowse link
G Msc musculin decreases expression EXP Metformin results in decreased expression of MSC mRNA CTD PMID:25596134 NCBI chr 5:4,547,335...4,553,206
Ensembl chr 5:4,547,405...4,553,203
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP Metformin results in increased expression of MSMO1 mRNA CTD PMID:31324951 NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO Metformin results in increased expression of COX1 protein CTD PMID:23166782 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt1 metallothionein 1 affects expression EXP Metformin affects the expression of MT1A mRNA; Metformin affects the expression of MT1F mRNA CTD PMID:31324951 NCBI chr19:10,826,032...10,827,048 JBrowse link
G Mt2A metallothionein 2A affects expression EXP Metformin affects the expression of MT2A mRNA CTD PMID:31324951 NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
JBrowse link
G Mtdh metadherin increases expression EXP Metformin results in increased expression of MTDH mRNA CTD PMID:25596134 NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases expression
decreases phosphorylation
ISO
EXP
[Metformin co-treated with Pioglitazone] results in decreased expression of MTOR mRNA; Metformin results in decreased phosphorylation of and results in increased expression of MTOR protein
Metformin decreases expression of MTOR protein in epithelial cell of alveolus of lung
Metformin results in decreased phosphorylation of MTOR protein
CTD
RGD
PMID:23363784 PMID:27363783 PMID:32589349 PMID:23632475 RGD:150404268 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mug2 murinoglobulin 2 decreases expression ISO Metformin results in decreased expression of MUG2 mRNA CTD PMID:23457588 NCBI chr 4:155,164,061...155,236,765
Ensembl chr 4:155,164,011...155,236,475
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP Metformin results in increased expression of MVD mRNA CTD PMID:31324951 NCBI chr19:50,496,366...50,506,389
Ensembl chr19:50,496,367...50,507,971
JBrowse link
G Mx2 MX dynamin like GTPase 2 increases expression EXP Metformin results in increased expression of MX2 mRNA CTD PMID:31324951 NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
decreases expression
multiple interactions
ISO
EXP
Metformin results in increased expression of MYC mRNA
Metformin results in decreased expression of MYC protein
[Paclitaxel co-treated with Metformin] results in decreased expression of MYC mRNA
Metformin results in decreased expression of MYC mRNA
CTD PMID:19022234 PMID:29226720 PMID:29309887 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP Metformin inhibits the reaction [Isoproterenol results in increased expression of MYD88 mRNA] CTD PMID:24842192 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Metformin inhibits the reaction [Doxorubicin results in decreased expression of MYH6 mRNA] CTD PMID:22666520 NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Metformin inhibits the reaction [Doxorubicin results in increased expression of MYH7 mRNA] CTD PMID:22666520 NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
JBrowse link
G Myzap myocardial zonula adherens protein multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MYZAP mRNA] CTD PMID:29095437 NCBI chr 8:72,155,817...72,243,036 JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase multiple interactions ISO
EXP
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of NAGLU mRNA]
Metformin inhibits the reaction [Streptozocin results in increased activity of NAGLU protein]
CTD PMID:29095437 PMID:33639173 NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase affects expression
multiple interactions
increases expression
ISO
EXP
Metformin affects the expression of NAMPT mRNA; Metformin affects the expression of NAMPT protein
Metformin inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA]
Metformin results in increased expression of NAMPT mRNA
SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA]
CTD PMID:23315983 PMID:25596134 PMID:32298659 NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression
increases expression
EXP Metformin results in decreased expression of NARS1 mRNA
Metformin results in increased expression of NARS mRNA
CTD PMID:25596134 PMID:31324951 NCBI chr18:57,989,308...58,005,639
Ensembl chr18:57,989,308...58,005,622
JBrowse link
G Ncapd2 non-SMC condensin I complex, subunit D2 increases expression EXP Metformin results in increased expression of NCAPD2 mRNA CTD PMID:25596134 NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression EXP Metformin results in decreased expression of NCF1 mRNA CTD PMID:31324951 NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression EXP Metformin results in decreased expression of NEDD9 mRNA CTD PMID:25596134 NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 decreases expression
multiple interactions
increases activity
affects activity
ISO
EXP
Metformin results in decreased expression of NFE2L2 mRNA; Metformin results in decreased expression of NFE2L2 protein
Metformin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein]
Metformin results in increased activity of NFE2L2 protein
Metformin affects the activity of NFE2L2 protein
Metformin inhibits the reaction [2-tert-butylhydroquinone results in increased stability of and affects the localization of NFE2L2 protein]
CTD PMID:22627169 PMID:23707609 PMID:25596134 PMID:30114225 PMID:33639173 NCBI chr 3:60,594,239...60,621,785
Ensembl chr 3:60,594,242...60,621,737
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
[Paclitaxel co-treated with Metformin] results in decreased expression of NFKB1 mRNA
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of NFKB1 mRNA]
CTD PMID:29309887 PMID:31100278 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of NFKB2 mRNA CTD PMID:29309887 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
ISO
EXP
Metformin results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein
Metformin results in decreased expression of NFKBIA mRNA
CTD PMID:21054339 PMID:31324951 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nin ninein increases expression EXP Metformin results in increased expression of NIN mRNA CTD PMID:25596134 NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639
JBrowse link
G Ninj1 ninjurin 1 increases expression EXP Metformin results in increased expression of NINJ1 mRNA CTD PMID:25596134 NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
JBrowse link
G Nmur1 neuromedin U receptor 1 decreases expression EXP Metformin results in decreased expression of NMUR1 mRNA CTD PMID:25596134 NCBI chr 9:87,033,231...87,038,070
Ensembl chr 9:87,033,279...87,036,684
JBrowse link
G Noct nocturnin affects expression EXP Metformin affects the expression of NOCT mRNA CTD PMID:31324951 NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of NOD1 mRNA CTD PMID:29309887 NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
JBrowse link
G Nop58 NOP58 ribonucleoprotein increases expression EXP Metformin results in increased expression of NOP58 mRNA CTD PMID:31324951 NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810
JBrowse link
G Nos1 nitric oxide synthase 1 affects response to substance ISO NOS1 protein affects the susceptibility to Metformin CTD PMID:20847317 NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
JBrowse link
G Nos2 nitric oxide synthase 2 increases response to substance
multiple interactions
increases expression
ISO
EXP
NOS2 protein results in increased susceptibility to Metformin
Metformin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased activity of NOS2 protein]
Metformin results in increased expression of NOS2 protein
CTD PMID:24770553 PMID:25108154 PMID:33639173 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP
ISO
Metformin inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]; Metformin inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]
[Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]
CTD PMID:25108154 PMID:25601987 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Metformin inhibits the reaction [Glucose results in increased expression of NPPA protein] CTD PMID:30144576 NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
JBrowse link
G Npy neuropeptide Y multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of NPY mRNA] CTD PMID:32652086 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
decreases expression
EXP
ISO
Metformin inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NQO1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NQO1 protein]
Metformin results in increased expression of NQO1 mRNA
Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of and results in increased activity of NQO1 protein]; Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NQO1 mRNA]
Metformin results in decreased expression of NQO1 protein
Metformin results in decreased expression of NQO1 mRNA
CTD PMID:21457706 PMID:22666520 PMID:23707609 PMID:25596134 PMID:25697376 More... NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO Metformin results in decreased expression of NR0B2 mRNA CTD PMID:24428821 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression EXP Metformin results in increased expression of NR1D1 mRNA CTD PMID:31324951 NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 decreases expression
multiple interactions
EXP
ISO
Metformin results in decreased expression of NR1I2 mRNA
Metformin binds to and results in increased activity of NR1I2 protein
Metformin binds to and results in increased activity of NR1I2 protein; NR1I2 protein affects the susceptibility to [Pregnenolone Carbonitrile co-treated with Metformin]
CTD PMID:19022234 PMID:21920351 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions EXP Metformin promotes the reaction [Phenobarbital results in increased activity of NR1I3 protein] CTD PMID:20686344 NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO Metformin results in decreased expression of NR3C1 mRNA; Metformin results in decreased expression of NR3C1 protein CTD PMID:25110054 NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression EXP Metformin results in decreased expression of NR4A1 mRNA CTD PMID:31324951 NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP Metformin results in decreased expression of NR4A2 mRNA CTD PMID:31324951 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression EXP Metformin results in decreased expression of NR4A3 mRNA CTD PMID:31324951 NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
JBrowse link
G Nras NRAS proto-oncogene, GTPase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of NRAS mRNA CTD PMID:29309887 NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO Metformin results in increased expression of NRF1 mRNA CTD PMID:16380484 PMID:24428821 NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
JBrowse link
G Ntpcr nucleoside-triphosphatase, cancer-related decreases expression EXP Metformin results in decreased expression of NTPCR mRNA CTD PMID:25596134 NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP Metformin results in increased expression of NUPR1 mRNA CTD PMID:31324951 NCBI chr 1:181,213,292...181,215,327 JBrowse link
G Oat ornithine aminotransferase decreases expression EXP Metformin results in decreased expression of OAT mRNA CTD PMID:31324951 NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
JBrowse link
G Oga O-GlcNAcase multiple interactions EXP Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein] CTD PMID:30551545 NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of OGG1 mRNA] CTD PMID:25697376 NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions EXP Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA] CTD PMID:27634381 NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
JBrowse link
G Olr906 olfactory receptor 906 decreases expression EXP Metformin results in decreased expression of OLR906 mRNA CTD PMID:31324951 NCBI chr 7:1,821,264...1,822,202
Ensembl chr 7:1,821,264...1,822,202
JBrowse link
G Onecut1 one cut homeobox 1 decreases expression EXP Metformin results in decreased expression of ONECUT1 mRNA CTD PMID:31324951 NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Metformin inhibits the reaction [Glucose results in decreased expression of OPA1 protein] CTD PMID:30144576 NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 decreases expression EXP Metformin results in decreased expression of ORAI3 mRNA CTD PMID:25596134 NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression
affects expression
EXP Metformin results in decreased expression of OSGIN1 mRNA
Metformin affects the expression of OSGIN1 mRNA
CTD PMID:25596134 PMID:31324951 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G Otub2 OTU deubiquitinase, ubiquitin aldehyde binding 2 increases expression EXP Metformin results in increased expression of OTUB2 mRNA CTD PMID:31324951 NCBI chr 6:122,545,029...122,563,651
Ensembl chr 6:122,545,061...122,563,644
JBrowse link
G Otud1 OTU deubiquitinase 1 decreases expression EXP Metformin results in decreased expression of OTUD1 mRNA CTD PMID:31324951 NCBI chr17:82,259,881...82,262,774
Ensembl chr17:82,259,840...82,262,995
JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression EXP Metformin results in increased expression of P2RX7 mRNA CTD PMID:31324951 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
JBrowse link
G Pank1 pantothenate kinase 1 decreases expression EXP Metformin results in decreased expression of PANK1 mRNA CTD PMID:25596134 NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
EXP
ISO
Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of PARP1 protein]
Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]
Metformin results in increased expression of PARP1 mRNA
[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA; Sodium Salicylate promotes the reaction [Metformin results in increased expression of PARP1 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA]
CTD PMID:27551045 PMID:29095437 PMID:29117515 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
decreases expression
ISO
EXP
Metformin inhibits the reaction [Bucladesine results in increased expression of PCK1 mRNA]; Metformin inhibits the reaction [PPARGC1A protein results in increased expression of PCK1 mRNA]
Metformin results in decreased expression of PCK1 mRNA
CTD PMID:22117073 PMID:24428821 PMID:31324951 NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
JBrowse link
G Pde8a phosphodiesterase 8A decreases expression EXP Metformin results in decreased expression of PDE8A mRNA CTD PMID:25596134 NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 multiple interactions ISO Metformin results in decreased phosphorylation of and results in increased activity of PDHA1 protein CTD PMID:28576465 NCBI chr  X:34,700,481...34,714,309
Ensembl chr  X:34,700,409...34,714,311
JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 decreases expression EXP Metformin results in decreased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 affects expression
increases expression
EXP Metformin affects the expression of PDK1 mRNA
Metformin results in increased expression of PDK1 mRNA
CTD PMID:25596134 PMID:31324951 NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP Metformin results in decreased expression of PDK4 mRNA CTD PMID:25596134 NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
JBrowse link
G Pdlim1 PDZ and LIM domain 1 increases expression EXP Metformin results in increased expression of PDLIM1 mRNA CTD PMID:25596134 NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression EXP Metformin results in decreased expression of PDLIM3 mRNA CTD PMID:31324951 NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases expression ISO Metformin results in decreased expression of PDPK1 mRNA CTD PMID:32589349 NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
JBrowse link
G Pdrg1 p53 and DNA damage regulated 1 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PDRG1 mRNA] CTD PMID:29095437 NCBI chr 3:141,477,561...141,483,730
Ensembl chr 3:141,476,501...141,483,858
Ensembl chr 3:141,476,501...141,483,858
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions
increases expression
ISO [Metformin co-treated with Glucose] affects the localization of PDX1 protein
Metformin results in increased expression of PDX1 protein
CTD PMID:16489446 NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO Metformin decreases expression of PECAM1 protein in epithelial cell of alveolus of lung RGD PMID:23632475 RGD:150404268 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
JBrowse link
G Penk proenkephalin increases expression EXP Metformin results in increased expression of PENK mRNA CTD PMID:31324951 NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
JBrowse link
G Per1 period circadian regulator 1 decreases expression EXP Metformin results in decreased expression of PER1 mRNA CTD PMID:31324951 NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression
multiple interactions
EXP
ISO
Metformin results in increased expression of PFKFB1 mRNA
PFKFB1 gene mutant form inhibits the reaction [Metformin results in decreased abundance of Glucose-6-Phosphate metabolite]; PFKFB1 gene mutant form inhibits the reaction [Metformin results in increased abundance of Glyceraldehyde 3-Phosphate metabolite]
CTD PMID:31324951 PMID:31974165 NCBI chr  X:19,508,522...19,562,165
Ensembl chr  X:19,508,546...19,562,182
JBrowse link
G Pgm2 phosphoglucomutase 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PGM2 mRNA] CTD PMID:29095437 NCBI chr14:44,166,314...44,199,823
Ensembl chr14:44,164,425...44,199,967
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Metformin results in increased expression of PHGDH mRNA CTD PMID:25596134 NCBI chr 2:185,906,964...185,936,160
Ensembl chr 2:185,906,966...185,935,944
JBrowse link
G Phkg1 phosphorylase kinase catalytic subunit gamma 1 decreases expression EXP Metformin results in decreased expression of PHKG1 mRNA CTD PMID:31324951 NCBI chr12:26,838,822...26,854,547
Ensembl chr12:26,838,968...26,852,850
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression
multiple interactions
EXP
ISO
Metformin results in increased expression of PHLDA3 mRNA
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PHLDA3 mRNA]
CTD PMID:25596134 PMID:29095437 NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
JBrowse link
G Pias2 protein inhibitor of activated STAT, 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PIAS2 mRNA] CTD PMID:29095437 NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033
JBrowse link
G Pidd1 p53-induced death domain protein 1 increases expression EXP Metformin results in increased expression of PIDD1 mRNA CTD PMID:25596134 NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 decreases expression
multiple interactions
ISO Metformin results in decreased expression of PIK3C3 mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3C3 mRNA
CTD PMID:32589349 NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions
decreases expression
ISO [Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CA mRNA
Metformin results in decreased expression of PIK3CA mRNA
CTD PMID:32589349 NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta multiple interactions ISO [Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CB mRNA CTD PMID:32589349 NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases expression
multiple interactions
ISO Metformin results in decreased expression of PIK3CG mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CG mRNA
CTD PMID:32589349 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression
multiple interactions
decreases expression
ISO
EXP
Metformin results in increased expression of PIK3R1 mRNA
Metformin inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]
Metformin results in decreased expression of PIK3R1 mRNA
CTD PMID:21870829 PMID:31324951 PMID:32652086 NCBI chr 2:32,878,942...32,963,611
Ensembl chr 2:32,882,032...32,963,631
JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PILRA mRNA] CTD PMID:29095437 NCBI chr12:17,787,169...17,798,149
Ensembl chr12:17,787,127...17,798,094
JBrowse link
G Pir pirin decreases expression EXP Metformin results in decreased expression of PIR mRNA CTD PMID:25596134 NCBI chr  X:30,108,536...30,219,269
Ensembl chr  X:30,108,538...30,219,218
JBrowse link
G Pklr pyruvate kinase L/R increases expression
multiple interactions
EXP Metformin results in increased expression of PKLR mRNA
Metformin inhibits the reaction [Glucose results in increased expression of PKLR mRNA]
CTD PMID:31324951 PMID:31974165 NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
JBrowse link
G Pla2g12a phospholipase A2, group XIIA affects expression EXP Metformin affects the expression of PLA2G12A mRNA CTD PMID:31324951 NCBI chr 2:218,436,450...218,452,760
Ensembl chr 2:218,436,513...218,452,740
JBrowse link
G Plat plasminogen activator, tissue type increases activity ISO Metformin results in increased activity of PLAT protein CTD PMID:1900072 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
JBrowse link
G Pld1 phospholipase D1 decreases expression
multiple interactions
ISO Metformin results in decreased expression of PLD1 mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of PLD1 mRNA
CTD PMID:32589349 NCBI chr 2:110,849,205...111,047,692
Ensembl chr 2:110,893,608...111,047,692
JBrowse link
G Plekhb1 pleckstrin homology domain containing B1 increases expression EXP Metformin results in increased expression of PLEKHB1 mRNA CTD PMID:31324951 NCBI chr 1:154,998,798...155,013,094
Ensembl chr 1:154,998,800...155,016,142
JBrowse link
G Plin2 perilipin 2 affects expression EXP Metformin affects the expression of PLIN2 mRNA CTD PMID:25596134 NCBI chr 5:101,156,643...101,211,738
Ensembl chr 5:101,154,411...101,242,319
JBrowse link
G Plk2 polo-like kinase 2 increases expression EXP Metformin results in increased expression of PLK2 mRNA CTD PMID:31324951 NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
JBrowse link
G Plppr1 phospholipid phosphatase related 1 increases expression EXP Metformin results in increased expression of PLPPR1 mRNA CTD PMID:31324951 NCBI chr 5:63,437,457...63,725,286
Ensembl chr 5:63,437,816...63,763,835
JBrowse link
G Pltp phospholipid transfer protein decreases expression EXP Metformin results in decreased expression of PLTP mRNA CTD PMID:31324951 NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 affects expression EXP Metformin affects the expression of PMEPA1 mRNA CTD PMID:25596134 NCBI chr 3:162,011,884...162,060,137
Ensembl chr 3:162,012,751...162,060,454
JBrowse link
G Pmm2 phosphomannomutase 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PMM2 mRNA] CTD PMID:29095437 NCBI chr10:6,961,521...6,982,913
Ensembl chr10:6,961,709...6,983,098
JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 affects expression EXP Metformin affects the expression of PNPLA3 mRNA CTD PMID:31324951 NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression EXP Metformin results in decreased expression of PNPLA6 mRNA CTD PMID:25596134 NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
JBrowse link
G Podxl podocalyxin-like increases expression EXP Metformin results in increased expression of PODXL mRNA CTD PMID:25596134 NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899
JBrowse link
G Polr3f RNA polymerase III subunit F increases expression EXP Metformin results in increased expression of POLR3F mRNA CTD PMID:25596134 NCBI chr 3:131,908,466...131,924,838
Ensembl chr 3:131,908,466...131,924,837
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] CTD PMID:32652086 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Pon1 paraoxonase 1 increases response to substance ISO PON1 gene mutant form results in increased susceptibility to Metformin CTD PMID:26945512 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO Metformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]] CTD PMID:22132214 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Ppan peter pan homolog increases expression EXP Metformin results in increased expression of PPAN mRNA CTD PMID:25596134 NCBI chr 8:19,423,908...19,427,941
Ensembl chr 8:19,423,961...19,427,938
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
increases activity
decreases expression
ISO
EXP
[rosiglitazone co-treated with Metformin] results in increased expression of PPARA mRNA; [rosiglitazone co-treated with Metformin] results in increased expression of PPARA protein; Metformin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]
Metformin results in increased expression of PPARA mRNA
Metformin results in increased activity of PPARA protein
Metformin results in decreased expression of PPARA mRNA
CTD PMID:20823565 PMID:22117073 PMID:23166782 PMID:23927877 PMID:29991592 More... NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
affects activity
increases expression
ISO
EXP
Metformin results in decreased expression of PPARG mRNA
Metformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA]
Metformin affects the activity of PPARG protein
Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]
Metformin results in increased expression of PPARG mRNA
CTD PMID:20724125 PMID:20956498 PMID:21870829 PMID:25108154 PMID:25596134 More... NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
ISO PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]
Metformin results in increased expression of PPARGC1A mRNA; Metformin results in increased expression of PPARGC1A protein
dorsomorphin inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [Bucladesine results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; Metformin inhibits the reaction [PPARGC1A protein results in decreased expression of TNFSF12 mRNA]; Metformin inhibits the reaction [PPARGC1A protein results in increased expression of PCK1 mRNA]; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; PRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; SIRT1 mutant form inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]
CTD PMID:15864539 PMID:16380484 PMID:22117073 PMID:23090186 PMID:24428821 NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
JBrowse link
G Ppfibp1 PPFIA binding protein 1 increases expression EXP Metformin results in increased expression of PPFIBP1 mRNA CTD PMID:25596134 NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PPM1D mRNA] CTD PMID:29095437 NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K decreases expression EXP Metformin results in decreased expression of PPM1K mRNA CTD PMID:31324951 NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP
ISO
Metformin results in increased expression of PPP1R15A mRNA CTD PMID:25596134 NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C increases expression EXP Metformin results in increased expression of PPP1R3C mRNA CTD PMID:31324951 NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
JBrowse link
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 decreases expression EXP Metformin results in decreased expression of PPP4R2 mRNA CTD PMID:25596134 NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression EXP Metformin results in increased expression of PRC1 mRNA CTD PMID:25596134 NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of PRDM1 mRNA CTD PMID:29309887 NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
JBrowse link
G Prdx2 peroxiredoxin 2 decreases expression ISO Metformin results in decreased expression of PRDX2 mRNA CTD PMID:23457588 NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions
increases phosphorylation
affects response to substance
ISO
EXP
Metformin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]; PRKAA1 protein affects the reaction [Metformin inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of ABCB1 protein]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of RELA protein]; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; PRKAA1 protein affects the reaction [Metformin results in increased expression of SOD2 mRNA]
Metformin increases expression and phosphorylation of PRKAA1 protein in epithelial cell of alveolus of lung
PRKAA1 protein affects the susceptibility to Metformin
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSHB protein results in increased phosphorylation of PRKAA1 protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased expression of HSD3B protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased secretion of Progesterone]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]
[[PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin] which results in increased abundance of Glucose-6-Phosphate; [PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]
CTD
RGD
PMID:16380484 PMID:16760380 PMID:16873680 PMID:19052259 PMID:19594306 More... RGD:150404268 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions
increases phosphorylation
increases activity
affects response to substance
ISO
EXP
Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein
metformin inhibits the reaction [lipopolysaccharide decreases expression of Prkaa2 mRNA in left cardiac chamber] and decreases expression of Prkaa2 mRNA in left cardiac chamber
Metformin results in increased phosphorylation of PRKAA2 protein
Metformin results in increased activity of PRKAA2 protein
PRKAA2 protein affects the susceptibility to Metformin
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein
[[PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin] which results in increased abundance of Glucose-6-Phosphate; [PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein; PRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]
CTD
RGD
PMID:16873680 PMID:18484962 PMID:19052259 PMID:19594306 PMID:20847317 More... RGD:39456138 NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 increases expression EXP Metformin results in increased expression of PRKAB2 mRNA CTD PMID:25596134 NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA] CTD PMID:32652086 NCBI chr 4:10,010,574...10,252,152
Ensembl chr 4:10,010,890...10,252,142
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases expression
ISO [Metformin co-treated with Pioglitazone] results in decreased expression of PRKCA mRNA; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]
Metformin results in decreased expression of PRKCA mRNA
CTD PMID:20590612 PMID:32589349 NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
JBrowse link
G Prkcb protein kinase C, beta decreases expression ISO Metformin results in decreased expression of PRKCB mRNA; Metformin results in decreased expression of PRKCB protein CTD PMID:15531508 NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
JBrowse link
G Prl prolactin decreases secretion ISO Metformin results in decreased secretion of PRL protein CTD PMID:21664031 NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression EXP Metformin results in increased expression of PSAT1 mRNA CTD PMID:31324951 NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP Metformin inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA] CTD PMID:26492952 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgfr prostaglandin F receptor decreases expression EXP Metformin results in decreased expression of PTGFR mRNA CTD PMID:31324951 NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Metformin inhibits the reaction [Dietary Fats results in increased expression of PTGS2 protein] CTD PMID:27551045 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO Metformin inhibits the reaction [INS protein results in increased expression of PTPN1 protein] CTD PMID:30928401 NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
JBrowse link
G Pxmp4 peroxisomal membrane protein 4 increases expression EXP Metformin results in increased expression of PXMP4 mRNA CTD PMID:31324951 NCBI chr 3:143,093,371...143,110,620
Ensembl chr 3:143,093,018...143,110,651
JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 increases expression EXP Metformin results in increased expression of PYCR1 mRNA CTD PMID:25596134 NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549
JBrowse link
G Pygl glycogen phosphorylase L decreases expression EXP Metformin results in decreased expression of PYGL mRNA CTD PMID:25596134 NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
JBrowse link
G Rab11a RAB11a, member RAS oncogene family increases expression
multiple interactions
ISO Metformin results in increased expression of RAB11A protein
Metformin inhibits the reaction [Ethinyl Estradiol results in decreased expression of RAB11A protein]
CTD PMID:34058177 NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
JBrowse link
G Rab33a RAB33A, member RAS oncogene family increases expression EXP Metformin results in increased expression of RAB33A mRNA CTD PMID:25596134 NCBI chr  X:127,694,219...127,706,378
Ensembl chr  X:127,694,964...127,706,378
JBrowse link
G Rab5a RAB5A, member RAS oncogene family multiple interactions EXP Metformin promotes the reaction [APPL1 protein binds to RAB5A protein] CTD PMID:29991592 NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873
JBrowse link
G Rad51c RAD51 paralog C multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of RAD51C mRNA] CTD PMID:29095437 NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO Metformin results in decreased phosphorylation of RAF1 protein CTD PMID:23707609 NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
JBrowse link
G Rbp4 retinol binding protein 4 multiple interactions EXP Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
JBrowse link
G Rbp7 retinol binding protein 7 increases expression EXP Metformin results in increased expression of RBP7 mRNA CTD PMID:31324951 NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339
JBrowse link
G Rd3l RD3 like decreases expression EXP Metformin results in decreased expression of RD3L mRNA CTD PMID:31324951 NCBI chr 6:131,042,274...131,044,178
Ensembl chr 6:131,042,185...131,044,163
JBrowse link
G Reg3g regenerating family member 3 gamma increases expression EXP Metformin results in increased expression of REG3G mRNA CTD PMID:31324951 NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases localization
multiple interactions
decreases phosphorylation
ISO
EXP
Metformin results in decreased localization of RELA protein
dorsomorphin inhibits the reaction [Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]; Metformin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein]; Metformin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]; Niacinamide inhibits the reaction [Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]
Metformin results in decreased phosphorylation of RELA protein
[Paclitaxel co-treated with Metformin] results in decreased expression of RELA mRNA; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [RELA protein results in increased expression of ABCB1 mRNA]; Metformin results in decreased expression of and affects the localization of RELA protein; PRKAA1 protein affects the reaction [Metformin results in decreased expression of RELA protein]
CTD PMID:16385087 PMID:21054339 PMID:25108154 PMID:27634381 PMID:29309887 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Retn resistin multiple interactions EXP Metformin inhibits the reaction [Fructose results in increased expression of RETN protein]; Metformin inhibits the reaction [Letrozole results in increased expression of RETN mRNA] CTD PMID:25108154 PMID:32298659 NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase decreases expression EXP Metformin results in decreased expression of RFFL mRNA CTD PMID:25596134 NCBI chr10:67,740,711...67,803,694
Ensembl chr10:67,740,712...67,824,434
JBrowse link
G RGD1305184 similar to CDNA sequence BC023105 decreases expression EXP Metformin results in decreased expression of RGD1305184 mRNA CTD PMID:31324951 NCBI chr18:53,838,426...53,854,858
Ensembl chr18:53,851,449...53,852,696
JBrowse link
G RGD1309362 similar to interferon-inducible GTPase increases expression EXP Metformin results in increased expression of RGD1309362 mRNA CTD PMID:31324951
G RGD1560801 similar to guanylate binding protein 1, interferon-inducible, 67kDa decreases expression EXP Metformin results in decreased expression of RGD1560801 mRNA CTD PMID:31324951 NCBI chr 2:231,517,485...231,525,865 JBrowse link
G RGD1560806 similar to Golgi phosphoprotein 3-like increases expression EXP Metformin results in increased expression of RGD1560806 mRNA CTD PMID:31324951 NCBI chr 9:45,890,492...45,891,363 JBrowse link
G RGD1563100 similar to KIAA0089 increases expression EXP Metformin results in increased expression of RGD1563100 mRNA CTD PMID:31324951 NCBI chr 7:91,940,258...91,942,125
Ensembl chr 7:91,940,260...91,942,559
JBrowse link
G RGD1563850 similar to Aldo-keto reductase family 1, member B8 decreases expression EXP Metformin results in decreased expression of RGD1563850 mRNA CTD PMID:31324951 NCBI chr 6:77,569,720...77,571,967 JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression EXP Metformin results in decreased expression of RGS2 mRNA CTD PMID:31324951 NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
JBrowse link
G Rhd Rh blood group, D antigen decreases expression EXP Metformin results in decreased expression of RHD mRNA CTD PMID:31324951 NCBI chr 5:147,087,479...147,121,716
Ensembl chr 5:147,087,518...147,121,715
JBrowse link
G Rhobtb1 Rho-related BTB domain containing 1 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of RHOBTB1 mRNA] CTD PMID:29095437 NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 multiple interactions
decreases expression
ISO [Metformin co-treated with Pioglitazone] results in decreased expression of RICTOR mRNA
Metformin results in decreased expression of RICTOR mRNA
CTD PMID:32589349 NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO [Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; [Simvastatin co-treated with Metformin] results in increased expression of RIPK1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]] CTD PMID:25412314 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of RIPK2 mRNA CTD PMID:29309887 NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO [Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]] CTD PMID:25412314 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
JBrowse link
G Rlf RLF zinc finger increases expression EXP Metformin results in increased expression of RLF mRNA CTD PMID:25596134 NCBI chr 5:134,711,612...134,767,274
Ensembl chr 5:134,711,619...134,767,257
JBrowse link
G Rnasel ribonuclease L multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of RNASEL mRNA] CTD PMID:29095437 NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704
JBrowse link
G Rnd1 Rho family GTPase 1 affects expression EXP Metformin affects the expression of RND1 mRNA CTD PMID:25596134 NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
JBrowse link
G Rnd3 Rho family GTPase 3 affects expression
increases expression
EXP Metformin affects the expression of RND3 mRNA
Metformin results in increased expression of RND3 mRNA
CTD PMID:25596134 PMID:31324951 NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
JBrowse link
G Rnf121 ring finger protein 121 increases expression EXP Metformin results in increased expression of RNF121 mRNA CTD PMID:25596134 NCBI chr 1:156,377,583...156,439,923
Ensembl chr 1:156,377,364...156,446,826
JBrowse link
G Ro60 Ro60, Y RNA binding protein affects expression EXP Metformin affects the expression of RO60 mRNA CTD PMID:25596134 NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
multiple interactions
ISO
EXP
Metformin results in decreased phosphorylation of RPS6 protein
Trientine inhibits the reaction [Metformin results in decreased phosphorylation of RPS6 protein]
Metformin analog results in decreased phosphorylation of RPS6 protein; Metformin results in decreased phosphorylation of RPS6 protein
CTD PMID:22492524 PMID:23363784 NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602
Ensembl chr 5:101,371,136...101,374,602
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 multiple interactions
increases expression
ISO [Metformin co-treated with Pioglitazone] results in increased expression of RPS6KA2 mRNA
Metformin results in increased expression of RPS6KA2 mRNA
CTD PMID:32589349 NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 multiple interactions
decreases expression
ISO [Metformin co-treated with Pioglitazone] results in decreased expression of RPS6KA5 mRNA
Metformin results in decreased expression of RPS6KA5 mRNA
CTD PMID:32589349 NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]
[Paclitaxel co-treated with Metformin] results in decreased expression of RPS6KB1 mRNA
CTD PMID:29309887 PMID:29859833 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression EXP Metformin results in increased expression of RRM2 mRNA CTD PMID:31324951 NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression EXP Metformin results in increased expression of RRM2B mRNA CTD PMID:25596134 NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
JBrowse link
G Rsl1d1 ribosomal L1 domain containing 1 increases expression EXP Metformin results in increased expression of RSL1D1 mRNA CTD PMID:25596134 NCBI chr10:4,424,868...4,436,753
Ensembl chr10:4,397,821...4,439,593
JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression EXP Metformin results in increased expression of RUNX1 mRNA CTD PMID:25596134 NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression EXP Metformin results in increased expression of RUNX2 protein CTD PMID:19594306 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Rxra retinoid X receptor alpha decreases expression EXP Metformin results in decreased expression of RXRA mRNA CTD PMID:25596134 NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
JBrowse link
G Sall1 spalt-like transcription factor 1 increases expression EXP Metformin results in increased expression of SALL1 mRNA CTD PMID:31324951 NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705
JBrowse link
G Sars1 seryl-tRNA synthetase 1 increases expression EXP Metformin results in increased expression of SARS1 mRNA CTD PMID:25596134 NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression EXP Metformin results in increased expression of SAT1 mRNA CTD PMID:25596134 NCBI chr  X:40,158,354...40,161,641
Ensembl chr  X:40,157,046...40,196,813
JBrowse link
G Sbk1 SH3 domain binding kinase 1 increases expression EXP Metformin results in increased expression of SBK1 mRNA CTD PMID:31324951 NCBI chr 1:180,807,092...180,851,910
Ensembl chr 1:180,807,099...180,851,885
JBrowse link
G Scamp1 secretory carrier membrane protein 1 increases expression EXP Metformin results in increased expression of SCAMP1 mRNA CTD PMID:25596134 NCBI chr 2:25,433,958...25,516,734
Ensembl chr 2:25,433,959...25,516,673
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression
ISO
EXP
[Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein
Metformin results in decreased expression of SCD1 mRNA
CTD PMID:28576465 PMID:31324951 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression EXP Metformin results in increased expression of SDF2L1 mRNA CTD PMID:25596134 NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
JBrowse link
G Sds serine dehydratase decreases expression EXP Metformin results in decreased expression of SDS mRNA CTD PMID:31324951 NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
JBrowse link
G Sec23b Sec23 homolog B, COPII coat complex component increases expression EXP Metformin results in increased expression of SEC23B mRNA CTD PMID:31324951 NCBI chr 3:131,939,011...131,981,489
Ensembl chr 3:131,939,337...131,981,489
JBrowse link
G Selenop selenoprotein P multiple interactions EXP Metformin inhibits the reaction [Dexamethasone results in increased expression of SELENOP mRNA]; Metformin inhibits the reaction [Dexamethasone results in increased secretion of SELENOP protein]; Metformin inhibits the reaction [Glucose results in increased expression of SELENOP mRNA]; Metformin inhibits the reaction [Glucose results in increased secretion of SELENOP protein] CTD PMID:19576170 NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
JBrowse link
G Sephs2 selenophosphate synthetase 2 multiple interactions EXP Metformin inhibits the reaction [Dexamethasone results in increased expression of SEPHS2 mRNA] CTD PMID:19576170 NCBI chr 1:181,893,146...181,895,464
Ensembl chr 1:181,892,599...181,895,497
JBrowse link
G Serpinc1 serpin family C member 1 increases activity ISO Metformin results in increased activity of SERPINC1 protein CTD PMID:29458015 NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein] CTD PMID:25108154 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Sertad1 SERTA domain containing 1 decreases expression EXP Metformin results in decreased expression of SERTAD1 mRNA CTD PMID:25596134 NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091
JBrowse link
G Sesn1 sestrin 1 decreases expression EXP Metformin results in decreased expression of SESN1 mRNA CTD PMID:25596134 NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
JBrowse link
G Sesn2 sestrin 2 multiple interactions
decreases expression
ISO
EXP
[Metformin co-treated with Rotenone] results in increased expression of SESN2 protein
Metformin results in decreased expression of SESN2 mRNA
CTD PMID:26031332 PMID:31324951