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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:metformin
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Accession:CHEBI:6801 term browser browse the term
Definition:A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Synonyms:exact_synonym: N,N-dimethylimidodicarbonimidic diamide
 related_synonym: 1,1-Dimethylbiguanide;   Formula=C4H11N5;   InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8);   InChIKey=XZWYZXLIPXDOLR-UHFFFAOYSA-N;   SMILES=CN(C)C(=N)NC(N)=N
 xref: CAS:657-24-9;   DrugBank:DB00331;   Drug_Central:1725;   HMDB:HMDB0001921;   KEGG:C07151;   KEGG:D04966;   LINCS:LSM-4730
 xref_mesh: MESH:D008687
 xref: PMID:11772907;   PMID:17062558;   PMID:18212742;   PMID:18608522;   PMID:24428821;   Reaxys:606492;   Wikipedia:Metformin
 cyclic_relationship: is_conjugate_base_of CHEBI:90688


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metformin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aacs acetoacetyl-CoA synthetase increases expression EXP Metformin results in increased expression of AACS mRNA CTD PMID:31324951 NCBI chr12:36,512,393...36,555,694
Ensembl chr12:36,512,393...36,555,694
JBrowse link
G Aars1 alanyl-tRNA synthetase 1 increases expression EXP Metformin results in increased expression of AARS mRNA CTD PMID:25596134 NCBI chr19:43,193,264...43,215,281
Ensembl chr19:43,193,257...43,215,281
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Metformin results in decreased expression of ABCB11 mRNA CTD PMID:27765674 NCBI chr 3:55,480,024...55,587,946
Ensembl chr 3:55,480,024...55,587,946
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases expression
ISO Metformin inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [RELA protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 protein]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of ABCB1 protein]
Metformin results in decreased expression of ABCB1 mRNA; Metformin results in decreased expression of ABCB1 protein
CTD PMID:21054339 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb1b ATP-binding cassette, subfamily B (MDR/TAP), member 1B increases expression EXP Metformin results in increased expression of ABCB1B mRNA CTD PMID:19022234 NCBI chr 4:22,225,123...22,307,577
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb4 ATP binding cassette subfamily B member 4 increases expression EXP Metformin results in increased expression of ABCB4 mRNA CTD PMID:31324951 NCBI chr 4:22,133,984...22,192,687
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcb6 ATP binding cassette subfamily B member 6 decreases expression EXP Metformin results in decreased expression of ABCB6 mRNA CTD PMID:25596134 NCBI chr 9:82,373,950...82,382,228
Ensembl chr 9:82,373,946...82,382,272
JBrowse link
G Abcb9 ATP binding cassette subfamily B member 9 affects expression EXP Metformin affects the expression of ABCB9 mRNA CTD PMID:25596134 NCBI chr12:37,923,974...37,956,678
Ensembl chr12:37,923,528...37,958,363
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 increases expression ISO Metformin results in increased expression of ABCC2 mRNA CTD PMID:19022234 NCBI chr 1:263,554,426...263,612,556
Ensembl chr 1:263,554,453...263,613,252
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 decreases expression EXP Metformin results in decreased expression of ABCC3 mRNA CTD PMID:25596134 NCBI chr10:82,047,308...82,116,928
Ensembl chr10:82,047,863...82,117,109
JBrowse link
G Abcc5 ATP binding cassette subfamily C member 5 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ABCC5 mRNA] CTD PMID:29095437 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
JBrowse link
G Abcc9 ATP binding cassette subfamily C member 9 multiple interactions ISO [rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 mRNA alternative form; [rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 protein alternative form CTD PMID:20823565 NCBI chr 4:176,806,098...176,928,540
Ensembl chr 4:176,805,431...176,922,424
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression
increases expression
EXP Metformin results in decreased expression of ABCG5 mRNA
Metformin results in increased expression of ABCG5 mRNA
CTD PMID:27765674, PMID:31324951 NCBI chr 6:7,935,771...7,961,207
Ensembl chr 6:7,935,771...7,961,207
JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 increases expression EXP Metformin results in increased expression of ABCG8 mRNA CTD PMID:31324951 NCBI chr 6:7,961,413...7,980,708
Ensembl chr 6:7,961,413...7,980,708
JBrowse link
G Abhd4 abhydrolase domain containing 4, N-acyl phospholipase B decreases expression EXP Metformin results in decreased expression of ABHD4 mRNA CTD PMID:25596134 NCBI chr15:32,888,233...32,906,861
Ensembl chr15:32,894,938...32,906,850
JBrowse link
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of ABL1 mRNA CTD PMID:29309887 NCBI chr 3:10,041,820...10,145,076
Ensembl chr 3:10,041,826...10,144,388
JBrowse link
G Ablim3 actin binding LIM protein family, member 3 increases expression EXP Metformin results in increased expression of ABLIM3 mRNA CTD PMID:31324951 NCBI chr18:57,126,534...57,245,965
Ensembl chr18:57,128,399...57,245,666
JBrowse link
G Acaca acetyl-CoA carboxylase alpha decreases expression
multiple interactions
increases expression
increases phosphorylation
affects phosphorylation
ISO
EXP
Metformin results in decreased expression of ACACA mRNA; Metformin results in decreased expression of ACACA protein
Metformin inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA]
Metformin results in increased expression of ACACA mRNA
Metformin results in increased phosphorylation of ACACA protein
Trientine inhibits the reaction [Metformin results in increased phosphorylation of ACACA protein]
Metformin analog affects the phosphorylation of ACACA protein
CTD PMID:16760380, PMID:16873680, PMID:20956498, PMID:22492524, PMID:29991592, PMID:31324951, PMID:32652086 NCBI chr10:71,519,392...71,719,910
Ensembl chr10:71,536,533...71,719,910
JBrowse link
G Acacb acetyl-CoA carboxylase beta increases phosphorylation ISO Metformin results in increased phosphorylation of ACACB protein CTD PMID:16873680 NCBI chr12:48,127,149...48,238,969
Ensembl chr12:48,127,149...48,238,887
JBrowse link
G Acat2 acetyl-CoA acetyltransferase 2 increases expression EXP Metformin results in increased expression of ACAT2 mRNA CTD PMID:31324951 NCBI chr 1:47,972,399...47,992,654
Ensembl chr 1:47,972,399...47,992,653
JBrowse link
G Ache acetylcholinesterase decreases activity ISO Metformin results in decreased activity of ACHE protein CTD PMID:28259689 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
JBrowse link
G Acly ATP citrate lyase multiple interactions
affects expression
ISO
EXP
[Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein
Metformin affects the expression of ACLY mRNA
CTD PMID:28576465, PMID:31324951 NCBI chr10:88,392,248...88,442,845
Ensembl chr10:88,392,248...88,442,845
JBrowse link
G Acmsd aminocarboxymuconate semialdehyde decarboxylase decreases expression EXP Metformin results in decreased expression of ACMSD mRNA CTD PMID:31324951 NCBI chr13:44,424,689...44,468,734
Ensembl chr13:44,424,689...44,468,734
JBrowse link
G Acot2 acyl-CoA thioesterase 2 increases expression EXP Metformin results in increased expression of ACOT2 mRNA CTD PMID:31324951 NCBI chr 6:107,460,596...107,468,324
Ensembl chr 6:107,460,668...107,467,487
JBrowse link
G Acot3 acyl-CoA thioesterase 3 increases expression EXP Metformin results in increased expression of ACOT3 mRNA CTD PMID:31324951 NCBI chr 6:107,531,508...107,537,446
Ensembl chr 6:107,531,528...107,536,789
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP Metformin results in decreased expression of ACSL1 mRNA CTD PMID:25596134 NCBI chr16:48,937,456...49,003,898
Ensembl chr16:48,937,456...49,003,246
JBrowse link
G Acsm3 acyl-CoA synthetase medium-chain family member 3 increases expression EXP Metformin results in increased expression of ACSM3 mRNA CTD PMID:31324951 NCBI chr 1:189,514,504...189,541,233
Ensembl chr 1:189,514,553...189,541,224
JBrowse link
G Acta1 actin, alpha 1, skeletal muscle increases expression EXP Metformin results in increased expression of ACTA1 mRNA CTD PMID:31324951 NCBI chr19:56,674,072...56,677,084
Ensembl chr19:56,674,074...56,677,084
JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions EXP Metformin inhibits the reaction [Dietary Fats results in increased expression of ACTA2 protein]; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]] CTD PMID:27551045, PMID:30551545 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
JBrowse link
G Actn1 actinin, alpha 1 increases expression EXP Metformin results in increased expression of ACTN1 mRNA CTD PMID:19022234 NCBI chr 6:103,376,557...103,470,497
Ensembl chr 6:103,375,799...103,470,555
JBrowse link
G Adgre1 adhesion G protein-coupled receptor E1 multiple interactions ISO Metformin inhibits the reaction [Folic Acid results in increased expression of ADGRE1 mRNA] CTD PMID:29380373 NCBI chr 9:9,431,888...9,585,883
Ensembl chr 9:9,431,860...9,585,865
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression EXP Metformin results in decreased expression of ADH4 mRNA CTD PMID:31324951 NCBI chr 2:243,702,035...243,720,063
Ensembl chr 2:243,700,784...243,740,899
JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing decreases expression
multiple interactions
increases expression
ISO
EXP
Metformin results in decreased expression of ADIPOQ mRNA
Metformin inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein]
Metformin results in increased expression of ADIPOQ protein
Metformin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA]
Cimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA]
CTD PMID:20956498, PMID:25108154, PMID:30256492, PMID:32652086 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
JBrowse link
G Adipor1 adiponectin receptor 1 increases expression EXP Metformin results in increased expression of ADIPOR1 mRNA CTD PMID:29991592 NCBI chr13:51,240,470...51,260,233
Ensembl chr13:51,240,911...51,260,228
JBrowse link
G Adipor2 adiponectin receptor 2 increases expression EXP metformin increases expression of Adipor2 mRNA in liver RGD PMID:24797033 RGD:25824940 NCBI chr 4:151,412,135...151,480,108
Ensembl chr 4:151,414,684...151,428,894
JBrowse link
G Aen apoptosis enhancing nuclease multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of AEN mRNA] CTD PMID:29095437 NCBI chr 1:140,584,328...140,593,749
Ensembl chr 1:140,584,380...140,593,745
JBrowse link
G Ager advanced glycosylation end product-specific receptor multiple interactions EXP Metformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Metformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] CTD PMID:22467055 NCBI chr20:4,363,152...4,366,079
Ensembl chr20:4,363,152...4,366,079
JBrowse link
G Agrn agrin decreases expression EXP Metformin results in decreased expression of AGRN mRNA CTD PMID:25596134 NCBI chr 5:173,589,910...173,622,813
Ensembl chr 5:173,589,819...173,622,645
JBrowse link
G Agrp agouti related neuropeptide multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA] CTD PMID:32652086 NCBI chr19:37,525,941...37,584,875
Ensembl chr19:37,526,419...37,528,011
JBrowse link
G Agt angiotensinogen multiple interactions ISO Metformin inhibits the reaction [AGT protein results in increased activity of and results in increased phosphorylation of HMGCR protein]; Metformin inhibits the reaction [AGT protein results in increased cleavage of and affects the localization of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased expression of LDLR protein]; Metformin inhibits the reaction [AGT protein results in increased expression of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of TNF protein] CTD PMID:29499335 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
JBrowse link
G Ahr aryl hydrocarbon receptor decreases expression
affects activity
multiple interactions
ISO
EXP
Metformin results in decreased expression of AHR mRNA; Metformin results in decreased expression of AHR protein
Metformin affects the activity of AHR protein
Metformin inhibits the reaction [SP1 protein results in increased expression of AHR protein]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]
CTD PMID:25110054, PMID:25596134, PMID:25697376 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 multiple interactions ISO Metformin inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein] CTD PMID:27562556 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087
JBrowse link
G Aifm2 apoptosis inducing factor, mitochondria associated 2 decreases expression EXP Metformin results in decreased expression of AIFM2 mRNA CTD PMID:25596134 NCBI chr20:31,329,047...31,353,548
Ensembl chr20:31,339,787...31,352,906
JBrowse link
G Ak3 adenylate kinase 3 decreases expression EXP Metformin results in decreased expression of AK3 mRNA CTD PMID:25596134 NCBI chr 1:247,144,486...247,169,690
Ensembl chr 1:247,144,491...247,169,693
JBrowse link
G Ak4 adenylate kinase 4 decreases expression EXP Metformin results in decreased expression of AK4 mRNA CTD PMID:25596134 NCBI chr 5:120,250,318...120,309,153
Ensembl chr 5:120,250,616...120,305,897
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO
EXP
[Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with INS protein] results in increased phosphorylation of AKT1 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of AKT1 mRNA; [Simvastatin co-treated with Metformin] results in decreased phosphorylation of AKT1 protein; Metformin inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]
Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA]
Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Testosterone results in increased phosphorylation of AKT1 protein]
CTD PMID:16385087, PMID:21664031, PMID:25412314, PMID:26492952, PMID:29309887, PMID:30742852, PMID:30914352, PMID:30928401, PMID:31743741, PMID:31877369, PMID:32652086 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
JBrowse link
G Akt2 AKT serine/threonine kinase 2 multiple interactions EXP Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein] CTD PMID:27270450 NCBI chr 1:84,400,939...84,451,223
Ensembl chr 1:84,411,726...84,450,162
JBrowse link
G Akt3 AKT serine/threonine kinase 3 decreases expression ISO Metformin results in decreased expression of AKT3 mRNA CTD PMID:32589349 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
JBrowse link
G Alas2 5'-aminolevulinate synthase 2 decreases expression EXP Metformin results in decreased expression of ALAS2 mRNA CTD PMID:31324951 NCBI chr  X:23,167,576...23,187,356
Ensembl chr  X:23,167,696...23,187,341
JBrowse link
G Aldh18a1 aldehyde dehydrogenase 18 family, member A1 increases expression EXP Metformin results in increased expression of ALDH18A1 mRNA CTD PMID:25596134 NCBI chr 1:259,641,673...259,674,521
Ensembl chr 1:259,641,676...259,674,425
Ensembl chr 1:259,641,676...259,674,425
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression EXP Metformin results in increased expression of ALDH1A1 mRNA CTD PMID:31324951 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Metformin results in increased expression of ALDOA mRNA CTD PMID:25596134 NCBI chr 1:198,228,387...198,233,988
Ensembl chr 1:198,228,387...198,233,588
JBrowse link
G Alox15 arachidonate 15-lipoxygenase decreases expression EXP Metformin results in decreased expression of ALOX15 mRNA CTD PMID:31324951 NCBI chr10:56,953,692...56,962,145
Ensembl chr10:56,953,691...56,962,161
JBrowse link
G Ambp alpha-1-microglobulin/bikunin precursor decreases expression EXP Metformin results in decreased expression of AMBP mRNA CTD PMID:25596134 NCBI chr 5:78,975,690...78,986,021
Ensembl chr 5:78,975,678...78,985,990
JBrowse link
G Angpt1 angiopoietin 1 decreases expression EXP Metformin results in decreased expression of ANGPT1 mRNA CTD PMID:31324951 NCBI chr 7:81,338,327...81,592,459
Ensembl chr 7:81,342,280...81,592,206
JBrowse link
G Angptl4 angiopoietin-like 4 decreases expression
increases expression
EXP Metformin results in decreased expression of ANGPTL4 mRNA
Metformin results in increased expression of ANGPTL4 mRNA
CTD PMID:25596134, PMID:31324951 NCBI chr 7:18,627,814...18,634,043
Ensembl chr 7:18,627,808...18,634,079
JBrowse link
G Angptl8 angiopoietin-like 8 increases expression EXP Metformin results in increased expression of ANGPTL8 mRNA CTD PMID:31324951 NCBI chr 8:22,855,495...22,858,565
Ensembl chr 8:22,856,539...22,858,565
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of APAF1 mRNA CTD PMID:29309887 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 multiple interactions ISO Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of APEX1 mRNA] CTD PMID:25697376 NCBI chr15:27,849,943...27,852,083
Ensembl chr15:27,849,979...27,852,082
JBrowse link
G Apoa5 apolipoprotein A5 decreases expression EXP Metformin results in decreased expression of APOA5 mRNA CTD PMID:31324951 NCBI chr 8:50,559,079...50,561,720
Ensembl chr 8:50,559,126...50,561,736
JBrowse link
G Apof apolipoprotein F decreases expression EXP Metformin results in decreased expression of APOF mRNA CTD PMID:31324951 NCBI chr 7:2,689,501...2,690,938
Ensembl chr 7:2,689,501...2,690,936
JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 multiple interactions
increases expression
EXP Metformin promotes the reaction [APPL1 protein binds to RAB5A protein]
Metformin results in increased expression of APPL1 protein
CTD PMID:29991592 NCBI chr16:2,560,103...2,602,035
Ensembl chr16:2,563,520...2,602,103
JBrowse link
G Aqp7 aquaporin 7 increases expression EXP Metformin results in increased expression of AQP7 mRNA CTD PMID:31324951 NCBI chr 5:57,358,297...57,372,332
Ensembl chr 5:57,358,327...57,372,239
JBrowse link
G Arfgap3 ADP-ribosylation factor GTPase activating protein 3 increases expression EXP Metformin results in increased expression of ARFGAP3 mRNA CTD PMID:31324951 NCBI chr 7:124,149,665...124,198,298
Ensembl chr 7:124,149,751...124,198,200
JBrowse link
G Arfgef2 ADP ribosylation factor guanine nucleotide exchange factor 2 increases expression EXP Metformin results in increased expression of ARFGEF2 mRNA CTD PMID:25596134 NCBI chr 3:163,570,435...163,656,612
Ensembl chr 3:163,570,532...163,656,626
JBrowse link
G Arg1 arginase 1 multiple interactions EXP
ISO
Metformin inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA]
Metformin inhibits the reaction [IL13 protein results in increased expression of ARG1 mRNA]
CTD PMID:25108154, PMID:26497364 NCBI chr 1:21,525,421...21,537,872
Ensembl chr 1:21,525,421...21,537,863
JBrowse link
G Arhgef10 Rho guanine nucleotide exchange factor 10 decreases expression EXP Metformin results in decreased expression of ARHGEF10 mRNA CTD PMID:25596134 NCBI chr16:79,725,629...79,817,065
Ensembl chr16:79,725,643...79,793,619
JBrowse link
G Arl1 ADP-ribosylation factor like GTPase 1 decreases expression EXP Metformin results in decreased expression of ARL1 mRNA CTD PMID:25596134 NCBI chr 7:29,282,411...29,293,455
Ensembl chr 7:29,282,305...29,293,399
JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression EXP Metformin results in decreased expression of ARNTL mRNA CTD PMID:31324951 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ARPC5L mRNA] CTD PMID:29095437 NCBI chr 3:23,301,455...23,309,077
Ensembl chr 3:23,301,455...23,309,072
JBrowse link
G Arrdc3 arrestin domain containing 3 decreases expression EXP Metformin results in decreased expression of ARRDC3 mRNA CTD PMID:31324951 NCBI chr 2:8,732,907...8,745,445
Ensembl chr 2:8,732,932...8,743,069
JBrowse link
G Asl argininosuccinate lyase decreases expression EXP Metformin results in decreased expression of ASL mRNA CTD PMID:31324951 NCBI chr12:30,160,922...30,178,348
Ensembl chr12:30,165,694...30,178,341
JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression EXP Metformin results in increased expression of ASNS mRNA CTD PMID:25596134, PMID:31324951 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
JBrowse link
G Atf3 activating transcription factor 3 increases expression EXP Metformin results in increased expression of ATF3 mRNA CTD PMID:25596134 NCBI chr13:109,817,892...109,849,632
Ensembl chr13:109,817,728...109,849,632
JBrowse link
G Atf4 activating transcription factor 4 affects activity EXP Metformin affects the activity of ATF4 protein CTD PMID:25596134 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Atf5 activating transcription factor 5 increases expression EXP Metformin results in increased expression of ATF5 mRNA CTD PMID:31324951 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522
JBrowse link
G Atm ATM serine/threonine kinase affects response to substance ISO ATM gene SNP affects the susceptibility to Metformin CTD PMID:21186350 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
JBrowse link
G Atp1a2 ATPase Na+/K+ transporting subunit alpha 2 decreases expression EXP Metformin results in decreased expression of ATP1A2 mRNA CTD PMID:31324951 NCBI chr13:90,651,682...90,676,629
Ensembl chr13:90,651,686...90,676,629
JBrowse link
G Atp1a3 ATPase Na+/K+ transporting subunit alpha 3 increases expression EXP Metformin results in increased expression of ATP1A3 mRNA CTD PMID:31324951 NCBI chr 1:81,852,423...81,881,565
Ensembl chr 1:81,852,429...81,881,549
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 multiple interactions EXP Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of ATP2A2 protein] CTD PMID:30290168 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
G Atp5mc2 ATP synthase membrane subunit c locus 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ATP5G2 mRNA] CTD PMID:29095437 NCBI chr 7:144,264,207...144,272,578
Ensembl chr 7:144,264,199...144,272,578
JBrowse link
G Atp6v0d2 ATPase H+ transporting V0 subunit D2 decreases expression EXP Metformin results in decreased expression of ATP6V0D2 mRNA CTD PMID:31324951 NCBI chr 5:33,843,591...33,892,446
Ensembl chr 5:33,843,519...33,892,462
JBrowse link
G Atr ATR serine/threonine kinase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of ATR mRNA CTD PMID:29309887 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
JBrowse link
G Aurkb aurora kinase B increases expression EXP Metformin results in increased expression of AURKB mRNA CTD PMID:25596134 NCBI chr10:55,625,860...55,632,399
Ensembl chr10:55,626,741...55,634,991
JBrowse link
G Aven apoptosis and caspase activation inhibitor multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of AVEN mRNA CTD PMID:29309887 NCBI chr 3:103,980,612...104,117,193
Ensembl chr 3:104,042,168...104,117,192
JBrowse link
G Bad BCL2-associated agonist of cell death increases expression
multiple interactions
ISO Metformin results in increased expression of BAD protein
Cisplatin promotes the reaction [Metformin results in increased expression of BAD protein]
CTD PMID:21388661 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
JBrowse link
G Bag1 BAG cochaperone 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of BAG1 mRNA CTD PMID:29309887 NCBI chr 5:57,254,421...57,267,002
Ensembl chr 5:57,254,421...57,267,002
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO
EXP
Cisplatin promotes the reaction [Metformin results in increased expression of BAX protein]
Metformin inhibits the reaction [Glucose results in increased expression of BAX protein]; Metformin inhibits the reaction [Testosterone results in decreased expression of BAX mRNA]
Metformin results in increased expression of BAX mRNA
CTD PMID:21388661, PMID:25596134, PMID:26492952, PMID:30144576 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
JBrowse link
G Bcat2 branched chain amino acid transaminase 2 decreases expression EXP Metformin results in decreased expression of BCAT2 mRNA CTD PMID:25596134, PMID:31324951 NCBI chr 1:101,553,900...101,572,103
Ensembl chr 1:101,554,642...101,572,080
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of BCL2 protein
Metformin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Metformin inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA]
[Paclitaxel co-treated with Metformin] results in decreased expression of BCL2 mRNA; Cisplatin promotes the reaction [Metformin results in decreased expression of BCL2 protein]
CTD PMID:21388661, PMID:26492952, PMID:29309887, PMID:30144576 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
decreases expression
ISO Cisplatin promotes the reaction [Metformin results in decreased expression of BCL2L1 protein] CTD PMID:21388661 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
JBrowse link
G Bcl6 BCL6, transcription repressor increases expression EXP Metformin results in increased expression of BCL6 mRNA CTD PMID:31324951 NCBI chr11:80,255,790...80,279,075
Ensembl chr11:80,255,790...80,279,075
JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Metformin inhibits the reaction [Methamphetamine results in decreased expression of BDNF protein] CTD PMID:30742852 NCBI chr 3:100,768,637...100,819,216
Ensembl chr 3:100,768,637...100,819,210
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 affects expression EXP Metformin affects the expression of BHLHE40 mRNA CTD PMID:25596134 NCBI chr 4:140,703,619...140,709,319
Ensembl chr 4:140,703,619...140,709,319
JBrowse link
G Bmf Bcl2 modifying factor decreases expression EXP Metformin results in decreased expression of BMF mRNA CTD PMID:25596134 NCBI chr 3:110,303,515...110,324,125
Ensembl chr 3:110,306,067...110,324,084
JBrowse link
G Bnip3 BCL2 interacting protein 3 increases expression EXP Metformin results in increased expression of BNIP3 mRNA CTD PMID:25596134 NCBI chr 1:211,248,098...211,265,282
Ensembl chr 1:211,248,098...211,265,282
JBrowse link
G Bpgm bisphosphoglycerate mutase decreases expression EXP Metformin results in decreased expression of BPGM mRNA CTD PMID:31324951 NCBI chr 4:61,912,210...61,940,697
Ensembl chr 4:61,912,210...61,940,696
JBrowse link
G Brd2 bromodomain containing 2 affects expression EXP Metformin affects the expression of BRD2 mRNA CTD PMID:25596134 NCBI chr20:3,910,555...3,921,074
Ensembl chr20:3,910,555...3,917,426
Ensembl chr20:3,910,555...3,917,426
JBrowse link
G Btg2 BTG anti-proliferation factor 2 affects expression
decreases expression
EXP Metformin affects the expression of BTG2 mRNA
Metformin results in decreased expression of BTG2 mRNA
CTD PMID:25596134, PMID:31324951 NCBI chr13:50,913,185...50,916,944
Ensembl chr13:50,913,180...50,916,982
JBrowse link
G Cacna1d calcium voltage-gated channel subunit alpha1 D decreases expression EXP Metformin results in decreased expression of CACNA1D mRNA CTD PMID:25596134 NCBI chr16:6,110,294...6,405,022
Ensembl chr16:6,112,150...6,405,117
JBrowse link
G Cars cysteinyl-tRNA synthetase increases expression EXP Metformin results in increased expression of CARS mRNA CTD PMID:25596134, PMID:31324951 NCBI chr 1:216,759,367...216,801,652
Ensembl chr 1:216,759,366...216,801,656
JBrowse link
G Casp1 caspase 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CASP1 mRNA CTD PMID:29309887 NCBI chr 8:2,605,743...2,614,637
Ensembl chr 8:2,604,962...2,614,631
JBrowse link
G Casp14 caspase 14 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CASP14 mRNA CTD PMID:29309887 NCBI chr 7:13,938,376...13,944,286
Ensembl chr 7:13,938,302...13,945,130
JBrowse link
G Casp3 caspase 3 multiple interactions
increases expression
decreases activity
increases activity
ISO
EXP
[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA; Cisplatin promotes the reaction [Metformin results in increased activity of CASP3 protein]; Metformin inhibits the reaction [sunitinib results in increased cleavage of CASP3 protein]; Sodium Salicylate promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of CASP3 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]
Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]
Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of CASP3 protein]; Metformin inhibits the reaction [Glucose results in increased activity of CASP3 protein]
Metformin results in decreased activity of CASP3 protein
CTD PMID:15531508, PMID:21388661, PMID:21906609, PMID:27551045, PMID:29095437, PMID:29117515, PMID:30144576 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp4 caspase 4 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CASP4 mRNA CTD PMID:29309887 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
JBrowse link
G Casp7 caspase 7 multiple interactions
increases activity
ISO
EXP
Cisplatin promotes the reaction [Metformin results in increased activity of CASP7 protein]; Metformin inhibits the reaction [Sunitinib results in increased cleavage of CASP7 protein]
2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]
CTD PMID:21388661, PMID:21906609, PMID:30551545 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
JBrowse link
G Casp8 caspase 8 decreases activity
multiple interactions
ISO Metformin results in decreased activity of CASP8 protein
[Paclitaxel co-treated with Metformin] results in increased expression of CASP8 mRNA
CTD PMID:15531508, PMID:29309887 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casq1 calsequestrin 1 decreases expression EXP Metformin results in decreased expression of CASQ1 mRNA CTD PMID:31324951 NCBI chr13:90,592,676...90,602,365
Ensembl chr13:90,592,681...90,602,365
JBrowse link
G Cat catalase multiple interactions
increases activity
decreases expression
increases expression
EXP
ISO
Metformin inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of CAT mRNA]
Metformin results in increased activity of CAT protein
Metformin promotes the reaction [Carbon Tetrachloride results in increased activity of CAT protein]
Metformin results in decreased expression of CAT mRNA
Metformin results in increased expression of CAT mRNA
CTD PMID:15531508, PMID:21457706, PMID:22627169, PMID:22666520, PMID:24717679, PMID:30958922 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
JBrowse link
G Cby1 chibby family member 1, beta catenin antagonist multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CBY1 mRNA] CTD PMID:29095437 NCBI chr 7:120,891,930...120,898,318
Ensembl chr 7:120,891,940...120,897,687
JBrowse link
G Ccdc38 coiled-coil domain containing 38 increases expression EXP Metformin results in increased expression of CCDC38 mRNA CTD PMID:31324951 NCBI chr 7:34,402,861...34,477,750
Ensembl chr 7:34,402,738...34,477,932
JBrowse link
G Ccdc77 coiled-coil domain containing 77 increases expression EXP Metformin results in increased expression of CCDC77 mRNA CTD PMID:31324951 NCBI chr 4:152,860,669...152,892,518
Ensembl chr 4:152,860,675...152,883,210
JBrowse link
G Ccdc90b coiled-coil domain containing 90B increases expression EXP Metformin results in increased expression of CCDC90B mRNA CTD PMID:25596134 NCBI chr 1:157,403,595...157,417,153
Ensembl chr 1:157,403,595...157,417,147
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of CCL2 mRNA
Metformin inhibits the reaction [AGT protein results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [Folic Acid results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL2 mRNA]
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA]
CTD PMID:20956498, PMID:25108154, PMID:26497364, PMID:29380373, PMID:29499335, PMID:30551545 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Ccl24 C-C motif chemokine ligand 24 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of CCL24 mRNA] CTD PMID:26497364 NCBI chr12:24,131,529...24,152,626
Ensembl chr12:24,148,567...24,152,625
JBrowse link
G Ccl27 C-C motif chemokine ligand 27 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of CCL27A mRNA] CTD PMID:29095437 NCBI chr 5:58,159,066...58,166,182
Ensembl chr 5:58,159,066...58,163,584
JBrowse link
G Ccl7 C-C motif chemokine ligand 7 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of CCL7 mRNA] CTD PMID:26497364 NCBI chr10:69,423,083...69,424,933
Ensembl chr10:69,423,086...69,424,979
JBrowse link
G Ccn2 cellular communication network factor 2 decreases expression EXP Metformin results in decreased expression of CCN2 mRNA CTD PMID:31324951 NCBI chr 1:21,851,657...21,854,773
Ensembl chr 1:21,851,660...21,854,773
JBrowse link
G Ccnb1 cyclin B1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCNB1 mRNA CTD PMID:29309887 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
JBrowse link
G Ccnb2 cyclin B2 multiple interactions
increases expression
ISO
EXP
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNB2 mRNA
Metformin results in increased expression of CCNB2 mRNA
CTD PMID:29309887, PMID:31324951 NCBI chr 8:76,847,972...76,861,165 JBrowse link
G Ccnc cyclin C multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCNC mRNA CTD PMID:29309887 NCBI chr 5:35,865,598...35,883,732
Ensembl chr 5:35,865,605...35,883,706
JBrowse link
G Ccnd1 cyclin D1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCND1 mRNA CTD PMID:29309887 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
JBrowse link
G Ccnd2 cyclin D2 multiple interactions
decreases expression
EXP
ISO
Metformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein]
[Paclitaxel co-treated with Metformin] results in decreased expression of CCND2 mRNA
Metformin results in decreased expression of CCND2 protein
CTD PMID:16760380, PMID:29309887 NCBI chr 4:159,674,885...159,697,207
Ensembl chr 4:159,674,885...159,697,207
JBrowse link
G Ccne1 cyclin E1 multiple interactions
decreases expression
EXP
ISO
Metformin inhibits the reaction [FSHB protein results in increased expression of CCNE1 protein]
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNE1 mRNA
Metformin results in decreased expression of CCNE1 protein
CTD PMID:16760380, PMID:29309887 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccnf cyclin F multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CCNF mRNA CTD PMID:29309887 NCBI chr10:13,594,687...13,619,935
Ensembl chr10:13,594,687...13,619,935
JBrowse link
G Ccng1 cyclin G1 increases expression
multiple interactions
EXP
ISO
Metformin results in increased expression of CCNG1 mRNA
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNG1 mRNA
CTD PMID:19022234, PMID:29309887 NCBI chr10:25,903,925...25,910,298
Ensembl chr10:25,903,911...25,910,325
JBrowse link
G Ccng2 cyclin G2 decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of CCNG2 mRNA
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNG2 mRNA
CTD PMID:25596134, PMID:29309887 NCBI chr14:16,267,572...16,276,068
Ensembl chr14:16,267,573...16,276,068
JBrowse link
G Ccr2 C-C motif chemokine receptor 2 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA] CTD PMID:26497364
G Cd14 CD14 molecule increases expression ISO Metformin results in increased expression of CD14 protein CTD PMID:26036281 NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
JBrowse link
G Cd40lg CD40 ligand multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CD40LG mRNA CTD PMID:29309887 NCBI chr  X:159,703,703...159,714,886
Ensembl chr  X:159,703,578...159,716,562
JBrowse link
G Cd52 CD52 molecule decreases expression EXP Metformin results in decreased expression of CD52 mRNA CTD PMID:31324951 NCBI chr 5:152,322,910...152,324,469
Ensembl chr 5:152,322,916...152,324,469
JBrowse link
G Cd63 Cd63 molecule increases expression EXP Metformin results in increased expression of CD63 mRNA CTD PMID:31324951 NCBI chr 7:3,320,250...3,335,583
Ensembl chr 7:3,320,103...3,335,582
JBrowse link
G Cd74 CD74 molecule decreases expression EXP Metformin results in decreased expression of CD74 mRNA CTD PMID:31324951 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
JBrowse link
G Cdc16 cell division cycle 16 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDC16 mRNA CTD PMID:29309887 NCBI chr16:81,493,355...81,516,493
Ensembl chr16:81,493,355...81,516,493
JBrowse link
G Cdc20 cell division cycle 20 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDC20 mRNA CTD PMID:29309887 NCBI chr 5:137,260,728...137,264,931
Ensembl chr 5:137,260,739...137,265,015
JBrowse link
G Cdc25a cell division cycle 25A multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDC25A mRNA CTD PMID:29309887 NCBI chr 8:117,953,223...117,971,552
Ensembl chr 8:117,953,444...117,971,519
JBrowse link
G Cdc25b cell division cycle 25B decreases expression EXP Metformin results in decreased expression of CDC25B mRNA CTD PMID:31324951 NCBI chr 3:123,731,539...123,741,696
Ensembl chr 3:123,731,539...123,741,339
JBrowse link
G Cdc34 cell division cycle 34, ubiqiutin conjugating enzyme multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDC34 mRNA CTD PMID:29309887 NCBI chr 7:12,899,957...12,905,339
Ensembl chr 7:12,899,958...12,905,339
JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO Metformin results in decreased expression of CDC42 mRNA CTD PMID:32589349 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
JBrowse link
G Cdip1 cell death-inducing p53 target 1 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CDIP1 mRNA] CTD PMID:29095437 NCBI chr10:10,966,819...10,989,937
Ensembl chr10:10,967,658...10,989,936
JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK1 mRNA CTD PMID:29309887 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
JBrowse link
G Cdk2 cyclin dependent kinase 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK2 mRNA CTD PMID:29309887 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Cdk4 cyclin-dependent kinase 4 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK4 mRNA CTD PMID:29309887 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
JBrowse link
G Cdk5r1 cyclin-dependent kinase 5 regulatory subunit 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK5R1 mRNA CTD PMID:29309887 NCBI chr10:67,862,054...67,863,255
Ensembl chr10:67,862,054...67,863,255
JBrowse link
G Cdk6 cyclin-dependent kinase 6 increases expression EXP Metformin results in increased expression of CDK6 mRNA CTD PMID:25596134 NCBI chr 4:27,781,728...27,969,653
Ensembl chr 4:27,785,647...27,966,398
JBrowse link
G Cdk7 cyclin-dependent kinase 7 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK7 mRNA CTD PMID:29309887 NCBI chr 2:30,710,642...30,735,522
Ensembl chr 2:30,710,643...30,735,514
JBrowse link
G Cdk8 cyclin-dependent kinase 8 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CDK8 mRNA CTD PMID:29309887 NCBI chr12:10,496,273...10,561,335 JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression
multiple interactions
EXP Metformin results in increased expression of CDKN1A mRNA
Metformin inhibits the reaction [Testosterone results in decreased expression of CDKN1A mRNA]
CTD PMID:25596134, PMID:26492952, PMID:31324951 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CDKN1B mRNA CTD PMID:29309887 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha decreases expression EXP Metformin results in decreased expression of CEBPA mRNA CTD PMID:19022234 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
JBrowse link
G Cers5 ceramide synthase 5 increases expression EXP Metformin results in increased expression of CERS5 mRNA CTD PMID:25596134 NCBI chr 7:141,386,391...141,424,375
Ensembl chr 7:141,386,391...141,424,343
JBrowse link
G Cfd complement factor D decreases expression ISO Metformin results in decreased expression of CFD mRNA CTD PMID:17148569 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Chek1 checkpoint kinase 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA CTD PMID:29309887 NCBI chr 8:39,181,162...39,201,588
Ensembl chr 8:39,181,163...39,243,882
JBrowse link
G Chek2 checkpoint kinase 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of CHEK2 mRNA CTD PMID:29309887 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression
multiple interactions
ISO Metformin results in decreased expression of CHUK mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of CHUK mRNA
CTD PMID:32589349 NCBI chr 1:263,848,829...263,884,354
Ensembl chr 1:263,848,884...263,885,169
JBrowse link
G Cish cytokine inducible SH2-containing protein decreases expression EXP Metformin results in decreased expression of CISH mRNA CTD PMID:31324951 NCBI chr 8:116,054,547...116,059,494
Ensembl chr 8:116,054,465...116,060,723
JBrowse link
G Ckap2 cytoskeleton associated protein 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CKAP2 mRNA] CTD PMID:29095437 NCBI chr16:74,752,655...74,779,184
Ensembl chr16:74,752,655...74,779,184
JBrowse link
G Cldn3 claudin 3 decreases expression EXP Metformin results in decreased expression of CLDN3 mRNA CTD PMID:31324951 NCBI chr12:21,831,341...21,832,813
Ensembl chr12:21,831,342...21,832,813
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog decreases expression EXP Metformin results in decreased expression of CMBL mRNA CTD PMID:25596134 NCBI chr 2:84,645,084...84,666,836
Ensembl chr 2:84,645,084...84,666,835
JBrowse link
G Cnppd1 cyclin Pas1/PHO80 domain containing 1 decreases expression EXP Metformin results in decreased expression of CNPPD1 mRNA CTD PMID:31324951 NCBI chr 9:82,338,865...82,345,262
Ensembl chr 9:82,338,866...82,345,262
JBrowse link
G Col4a1 collagen type IV alpha 1 chain multiple interactions ISO Metformin inhibits the reaction [Folic Acid results in increased expression of COL4A1 mRNA] CTD PMID:29380373 NCBI chr16:83,522,162...83,632,153
Ensembl chr16:83,522,162...83,632,153
JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A decreases expression
affects expression
EXP Metformin results in decreased expression of CPT1A mRNA
Metformin affects the expression of CPT1A mRNA
CTD PMID:19022234, PMID:31324951 NCBI chr 1:218,568,157...218,629,679
Ensembl chr 1:218,569,510...218,629,678
JBrowse link
G Cptp ceramide-1-phosphate transfer protein multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CPTP mRNA] CTD PMID:29095437 NCBI chr 5:173,314,219...173,318,384
Ensembl chr 5:173,314,228...173,318,313
JBrowse link
G Creb1 cAMP responsive element binding protein 1 multiple interactions EXP Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of CREB1 protein] CTD PMID:30742852 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
JBrowse link
G Creb3l2 cAMP responsive element binding protein 3-like 2 multiple interactions
increases expression
ISO
EXP
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CREB3L2 mRNA]
Metformin results in increased expression of CREB3L2 mRNA
CTD PMID:29095437, PMID:31324951 NCBI chr 4:64,869,285...64,981,519
Ensembl chr 4:64,869,026...64,981,384
JBrowse link
G Crebrf CREB3 regulatory factor decreases expression EXP Metformin results in decreased expression of CREBRF mRNA CTD PMID:31324951 NCBI chr10:16,693,846...16,753,162
Ensembl chr10:16,694,792...16,752,205
JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 increases expression EXP Metformin results in increased expression of CRELD2 mRNA CTD PMID:31324951 NCBI chr 7:129,812,746...129,819,641
Ensembl chr 7:129,812,789...129,819,634
JBrowse link
G Crot carnitine O-octanoyltransferase increases expression EXP Metformin results in increased expression of CROT mRNA CTD PMID:31324951 NCBI chr 4:22,079,837...22,116,265
Ensembl chr 4:22,081,604...22,116,265
JBrowse link
G Crp C-reactive protein decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of CRP protein
Metformin inhibits the reaction [Fructose results in increased expression of CRP protein]
CTD PMID:14557435, PMID:25108154 NCBI chr13:91,080,448...91,081,358
Ensembl chr13:91,054,974...91,093,713
JBrowse link
G Cst3 cystatin C multiple interactions EXP Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein] CTD PMID:30551545 NCBI chr 3:143,219,671...143,223,544
Ensembl chr 3:143,219,686...143,223,615
JBrowse link
G Ctdp1 CTD phosphatase subunit 1 increases expression EXP Metformin results in increased expression of CTDP1 mRNA CTD PMID:25596134 NCBI chr18:76,922,913...76,985,095
Ensembl chr18:76,922,934...76,984,203
JBrowse link
G Ctdsp2 CTD small phosphatase 2 decreases expression EXP Metformin results in decreased expression of CTDSP2 mRNA CTD PMID:31324951 NCBI chr 7:70,283,683...70,291,795
Ensembl chr 7:70,283,710...70,288,568
JBrowse link
G Cth cystathionine gamma-lyase decreases expression EXP Metformin results in decreased expression of CTH mRNA CTD PMID:25596134 NCBI chr 2:264,266,959...264,293,040
Ensembl chr 2:264,266,984...264,293,046
JBrowse link
G Ctsc cathepsin C decreases expression EXP Metformin results in decreased expression of CTSC mRNA CTD PMID:25596134 NCBI chr 1:151,918,514...151,949,979
Ensembl chr 1:151,918,571...151,949,983
JBrowse link
G Cttn cortactin increases expression EXP Metformin results in increased expression of CTTN mRNA CTD PMID:25596134 NCBI chr 1:217,602,698...217,638,196
NCBI chr 1:215,255,385...215,290,882
Ensembl chr 1:217,602,698...217,638,152
Ensembl chr 1:217,602,698...217,638,152
JBrowse link
G Cttnbp2nl CTTNBP2 N-terminal like multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of CTTNBP2NL mRNA] CTD PMID:29095437 NCBI chr 2:207,495,056...207,541,808
Ensembl chr 2:207,495,055...207,541,645
JBrowse link
G Cxcl1 C-X-C motif chemokine ligand 1 affects expression EXP Metformin affects the expression of CXCL1 mRNA CTD PMID:31324951 NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
JBrowse link
G Cxcl13 C-X-C motif chemokine ligand 13 decreases expression EXP Metformin results in decreased expression of CXCL13 mRNA CTD PMID:31324951 NCBI chr14:15,253,146...15,258,221
Ensembl chr14:15,253,125...15,258,207
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of CXCL2 mRNA] CTD PMID:26497364 NCBI chr14:18,731,346...18,733,391
Ensembl chr14:18,731,378...18,733,391
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 decreases expression EXP Metformin results in decreased expression of CXCL9 mRNA CTD PMID:31324951 NCBI chr14:17,228,832...17,233,743
Ensembl chr14:17,228,856...17,234,712
JBrowse link
G Cyba cytochrome b-245 alpha chain decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of CYBA mRNA
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA]
CTD PMID:15531508, PMID:27634381 NCBI chr19:55,249,634...55,257,824
Ensembl chr19:55,249,616...55,257,876
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 multiple interactions EXP Metformin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein] CTD PMID:16760380 NCBI chr 8:62,798,317...62,809,848
Ensembl chr 8:62,779,875...62,809,893
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression
multiple interactions
affects expression
ISO
EXP
Metformin results in decreased expression of CYP17A1 mRNA
Metformin inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA]
Metformin affects the expression of CYP17A1 mRNA
CTD PMID:23166782, PMID:31324951, PMID:32298659 NCBI chr 1:266,422,127...266,429,947
Ensembl chr 1:266,422,132...266,428,239
JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 multiple interactions EXP Metformin inhibits the reaction [FSHB protein results in increased expression of CYP19A1 protein] CTD PMID:16760380 NCBI chr 8:58,744,849...58,772,408
Ensembl chr 8:58,744,849...58,772,408
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression
increases expression
ISO
EXP
Metformin promotes the reaction [Streptozocin results in increased expression of CYP1A1 mRNA]
Metformin results in decreased expression of CYP1A1 mRNA
Metformin results in decreased expression of CYP1A1 mRNA; Metformin results in decreased expression of CYP1A1 protein
Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of and results in increased activity of CYP1A1 protein]; Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
Metformin results in increased expression of CYP1A1 mRNA
CTD PMID:22342832, PMID:25110054, PMID:25596134, PMID:25697376 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression
decreases expression
ISO
EXP
Metformin results in increased expression of CYP1A2 mRNA
Metformin results in decreased expression of CYP1A2 mRNA
CTD PMID:19022234, PMID:25596134 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases expression
ISO Metformin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein]
Metformin results in decreased expression of CYP1B1 mRNA; Metformin results in decreased expression of CYP1B1 protein
CTD PMID:25110054 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Cyp27b1 cytochrome P450, family 27, subfamily b, polypeptide 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of CYP27B1 mRNA CTD PMID:29309887 NCBI chr 7:70,333,150...70,340,006
Ensembl chr 7:70,335,061...70,340,005
JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 increases expression ISO Metformin results in increased expression of CYP2B10 mRNA CTD PMID:22342832 NCBI chr 7:99,142,431...99,183,540
Ensembl chr 7:99,142,450...99,181,783
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions ISO Metformin promotes the reaction [Streptozocin results in increased expression of CYP2B9 mRNA] CTD PMID:22342832 NCBI chr 1:83,163,103...83,236,615
Ensembl chr 1:83,163,079...83,236,615
JBrowse link
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 increases expression EXP Metformin results in increased expression of CYP2C12 mRNA CTD PMID:31324951 NCBI chr 1:258,709,726...258,766,873
Ensembl chr 1:258,709,721...258,766,881
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 increases expression ISO Metformin results in increased expression of CYP2E1 mRNA CTD PMID:22342832 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions
affects expression
EXP Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein]
Metformin affects the expression of CYP7A1 mRNA
CTD PMID:31100278, PMID:31324951 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Cyp8b1 cytochrome P450 family 8 subfamily B member 1 increases expression EXP Metformin results in increased expression of CYP8B1 mRNA CTD PMID:31324951 NCBI chr 8:130,548,418...130,550,388
Ensembl chr 8:130,548,418...130,550,388
JBrowse link
G Dapk1 death associated protein kinase 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of DAPK1 mRNA CTD PMID:29309887 NCBI chr17:4,297,038...4,454,941
Ensembl chr17:4,297,224...4,454,778
JBrowse link
G Dcxr dicarbonyl and L-xylulose reductase decreases expression EXP Metformin results in decreased expression of DCXR mRNA CTD PMID:31324951 NCBI chr10:109,906,119...109,909,696
Ensembl chr10:109,906,815...109,909,715
JBrowse link
G Ddhd1 DDHD domain containing 1 increases expression EXP Metformin results in increased expression of DDHD1 mRNA CTD PMID:31324951 NCBI chr15:19,963,639...20,032,263
Ensembl chr15:19,965,187...20,032,191
JBrowse link
G Ddi2 DNA damage inducible 1 homolog 2 decreases expression EXP Metformin results in decreased expression of DDI2 mRNA CTD PMID:31324951 NCBI chr 5:160,230,958...160,282,836
Ensembl chr 5:160,230,955...160,282,810
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression EXP Metformin results in increased expression of DDIT3 mRNA CTD PMID:25596134 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Ddit4 DNA-damage-inducible transcript 4 decreases expression
multiple interactions
increases expression
EXP
ISO
Metformin results in decreased expression of DDIT4 mRNA
[Metformin co-treated with Pioglitazone] results in increased expression of DDIT4 mRNA
Metformin results in increased expression of DDIT4 mRNA
CTD PMID:25596134, PMID:32589349 NCBI chr20:29,509,283...29,511,382
Ensembl chr20:29,509,289...29,511,382
JBrowse link
G Ddit4l DNA-damage-inducible transcript 4-like multiple interactions ISO [Metformin co-treated with Pioglitazone] results in increased expression of DDIT4L mRNA CTD PMID:32589349 NCBI chr 2:242,882,219...242,885,088
Ensembl chr 2:242,882,306...242,885,131
JBrowse link
G Ddx17 DEAD-box helicase 17 increases expression EXP Metformin results in increased expression of DDX17 mRNA CTD PMID:25596134 NCBI chr 7:120,761,843...120,765,012
Ensembl chr 7:120,761,826...120,780,641
JBrowse link
G Ddx24 DEAD-box helicase 24 increases expression EXP Metformin results in increased expression of DDX24 mRNA CTD PMID:25596134 NCBI chr 6:127,302,201...127,319,382
Ensembl chr 6:127,302,201...127,319,362
JBrowse link
G Denr density regulated reinitiation and release factor multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DENR mRNA] CTD PMID:29095437 NCBI chr12:38,095,717...38,117,758
Ensembl chr12:38,096,034...38,116,919
JBrowse link
G Deptor DEP domain containing MTOR-interacting protein multiple interactions
decreases expression
ISO [Metformin co-treated with Pioglitazone] results in decreased expression of DEPTOR mRNA
Metformin results in decreased expression of DEPTOR mRNA
CTD PMID:32589349 NCBI chr 7:94,795,161...95,000,750
Ensembl chr 7:94,795,214...94,995,809
JBrowse link
G Dffa DNA fragmentation factor subunit alpha multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of DFFA mRNA CTD PMID:29309887 NCBI chr 5:165,922,893...165,935,822
Ensembl chr 5:165,922,915...165,935,821
JBrowse link
G Dgka diacylglycerol kinase, alpha increases expression EXP Metformin results in increased expression of DGKA mRNA CTD PMID:25596134 NCBI chr 7:3,143,826...3,170,764
Ensembl chr 7:3,143,827...3,170,146
JBrowse link
G Dhx37 DEAH-box helicase 37 increases expression EXP Metformin results in increased expression of DHX37 mRNA CTD PMID:25596134 NCBI chr12:36,594,058...36,614,165
Ensembl chr12:36,594,047...36,614,210
JBrowse link
G Dhx9 DExH-box helicase 9 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DHX9 mRNA] CTD PMID:29095437 NCBI chr13:70,885,503...70,922,278
Ensembl chr13:70,885,504...70,922,245
JBrowse link
G Diablo diablo, IAP-binding mitochondrial protein multiple interactions ISO Metformin inhibits the reaction [Acetaminophen affects the localization of DIABLO protein] CTD PMID:27562556 NCBI chr12:38,490,230...38,503,344
Ensembl chr12:38,490,230...38,503,330
JBrowse link
G Dlat dihydrolipoamide S-acetyltransferase increases expression EXP Metformin results in increased expression of DLAT mRNA CTD PMID:31324951 NCBI chr 8:55,062,549...55,087,832
Ensembl chr 8:55,062,551...55,087,832
JBrowse link
G Dlgap5 DLG associated protein 5 increases expression EXP Metformin results in increased expression of DLGAP5 mRNA CTD PMID:25596134 NCBI chr15:24,167,484...24,199,417
Ensembl chr15:24,167,486...24,199,341
JBrowse link
G Dmbt1 deleted in malignant brain tumors 1 increases expression EXP Metformin results in increased expression of DMBT1 mRNA CTD PMID:31324951 NCBI chr 1:201,620,642...201,689,905
NCBI chr 1:203,149,414...203,228,705
JBrowse link
G Dmxl2 Dmx-like 2 decreases expression EXP Metformin results in decreased expression of DMXL2 mRNA CTD PMID:31324951 NCBI chr 8:58,932,575...59,077,788
Ensembl chr 8:58,932,580...59,077,690
JBrowse link
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 increases expression EXP Metformin results in increased expression of DNAJB9 mRNA CTD PMID:25596134 NCBI chr 6:64,165,913...64,170,122
Ensembl chr 6:64,165,913...64,170,151
JBrowse link
G Dnm1l dynamin 1-like multiple interactions EXP Metformin inhibits the reaction [Glucose results in increased expression of DNM1L protein] CTD PMID:30144576 NCBI chr11:88,830,968...88,882,271
Ensembl chr11:88,830,957...88,880,198
JBrowse link
G Dnmbp dynamin binding protein decreases expression EXP Metformin results in decreased expression of DNMBP mRNA CTD PMID:25596134 NCBI chr 1:263,625,503...263,718,784
Ensembl chr 1:263,625,501...263,718,745
JBrowse link
G Dpep1 dipeptidase 1 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DPEP1 mRNA] CTD PMID:29095437 NCBI chr19:55,973,447...55,998,830
Ensembl chr19:55,982,740...55,998,208
JBrowse link
G Dpp9 dipeptidyl peptidase 9 decreases expression EXP Metformin results in decreased expression of DPP9 mRNA CTD PMID:25596134 NCBI chr 9:10,846,493...10,882,560
Ensembl chr 9:10,846,596...10,882,649
JBrowse link
G Dusp1 dual specificity phosphatase 1 decreases expression EXP Metformin results in decreased expression of DUSP1 mRNA CTD PMID:31324951 NCBI chr10:16,970,642...16,973,425
Ensembl chr10:16,970,626...16,973,418
JBrowse link
G Dusp22 dual specificity phosphatase 22 decreases expression EXP Metformin results in decreased expression of DUSP22 mRNA CTD PMID:25596134 NCBI chr17:34,986,589...35,037,297
Ensembl chr17:34,986,591...35,037,076
JBrowse link
G Dusp4 dual specificity phosphatase 4 increases expression EXP Metformin results in increased expression of DUSP4 mRNA CTD PMID:19664596 NCBI chr16:61,080,767...61,090,973
Ensembl chr16:61,078,175...61,091,169
JBrowse link
G Dusp5 dual specificity phosphatase 5 increases expression EXP
ISO
Metformin results in increased expression of DUSP5 mRNA CTD PMID:25596134 NCBI chr 1:274,245,184...274,258,595
Ensembl chr 1:274,245,184...274,258,595
JBrowse link
G E2f4 E2F transcription factor 4 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of E2F4 mRNA CTD PMID:29309887 NCBI chr19:37,252,828...37,260,239
Ensembl chr19:37,252,843...37,260,239
JBrowse link
G Ech1 enoyl-CoA hydratase 1 increases expression EXP Metformin results in increased expression of ECH1 mRNA CTD PMID:31324951 NCBI chr 1:87,009,798...87,015,996
Ensembl chr 1:87,009,730...87,016,005
JBrowse link
G Eci1 enoyl-CoA delta isomerase 1 increases expression EXP Metformin results in increased expression of ECI1 mRNA CTD PMID:31324951 NCBI chr10:13,797,573...13,810,918
Ensembl chr10:13,797,562...13,810,913
JBrowse link
G Eda2r ectodysplasin A2 receptor increases expression
multiple interactions
EXP
ISO
Metformin results in increased expression of EDA2R mRNA
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of EDA2R mRNA]
CTD PMID:25596134, PMID:29095437 NCBI chr  X:66,560,200...66,602,509
Ensembl chr  X:66,561,286...66,602,506
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP
ISO
Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein]
Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]
CTD PMID:25108154, PMID:26497364 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Efna1 ephrin A1 decreases expression EXP Metformin results in decreased expression of EFNA1 mRNA CTD PMID:25596134 NCBI chr 2:188,588,808...188,596,156
Ensembl chr 2:188,588,796...188,596,222
JBrowse link
G Egr1 early growth response 1 increases expression EXP Metformin results in increased expression of EGR1 mRNA CTD PMID:19664596, PMID:31324951 NCBI chr18:27,657,903...27,660,101
Ensembl chr18:27,657,628...27,661,429
JBrowse link
G Eif1 eukaryotic translation initiation factor 1 increases expression EXP Metformin results in increased expression of EIF1 mRNA CTD PMID:25596134 NCBI chr10:88,227,455...88,229,546
Ensembl chr10:88,227,360...88,229,765
JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta increases expression EXP Metformin results in increased expression of EIF2S2 mRNA CTD PMID:25596134 NCBI chr 3:150,391,455...150,412,179
Ensembl chr 3:150,391,460...150,412,179
JBrowse link
G Eif3c eukaryotic translation initiation factor 3, subunit C increases expression EXP Metformin results in increased expression of EIF3C mRNA CTD PMID:25596134 NCBI chr 1:197,964,406...197,982,917
Ensembl chr 1:197,964,407...197,982,601
JBrowse link
G Eif4e eukaryotic translation initiation factor 4E decreases expression
multiple interactions
ISO Metformin results in decreased expression of EIF4E mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of EIF4E mRNA
CTD PMID:32589349 NCBI chr 2:243,819,616...243,853,987
Ensembl chr 2:243,820,661...243,852,631
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 decreases phosphorylation
multiple interactions
ISO Metformin results in decreased phosphorylation of EIF4EBP1 protein
Metformin results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein
CTD PMID:22108913, PMID:23363784 NCBI chr16:68,954,860...68,968,248
Ensembl chr16:68,954,875...68,968,248
JBrowse link
G Elf4 E74 like ETS transcription factor 4 increases expression EXP Metformin results in increased expression of ELF4 mRNA CTD PMID:25596134 NCBI chr  X:135,239,626...135,284,330
Ensembl chr  X:135,240,451...135,250,519
JBrowse link
G Elk4 ETS transcription factor ELK4 increases expression ISO Metformin results in increased expression of ELK4 mRNA CTD PMID:25596134 NCBI chr13:48,788,262...48,813,267
Ensembl chr13:48,790,509...48,813,260
JBrowse link
G Elovl6 ELOVL fatty acid elongase 6 decreases expression
affects expression
ISO
EXP
Metformin results in decreased expression of ELOVL6 protein
Metformin affects the expression of ELOVL6 mRNA
CTD PMID:28576465, PMID:31324951 NCBI chr 2:234,187,490...234,296,124
Ensembl chr 2:234,189,105...234,296,145
Ensembl chr 2:234,189,105...234,296,145
JBrowse link
G Emb embigin decreases expression EXP Metformin results in decreased expression of EMB mRNA CTD PMID:31324951 NCBI chr 2:49,682,763...49,733,475
Ensembl chr 2:49,682,754...49,732,253
JBrowse link
G Eno2 enolase 2 increases expression EXP Metformin results in increased expression of ENO2 mRNA CTD PMID:25596134 NCBI chr 4:157,285,192...157,294,090
Ensembl chr 4:157,285,179...157,294,047
JBrowse link
G Entpd7 ectonucleoside triphosphate diphosphohydrolase 7 increases expression EXP Metformin results in increased expression of ENTPD7 mRNA CTD PMID:31324951 NCBI chr 1:263,448,633...263,490,308
Ensembl chr 1:263,448,633...263,490,308
Ensembl chr 1:263,448,633...263,490,308
JBrowse link
G Ep400 E1A binding protein p400 affects expression EXP Metformin affects the expression of EP400 mRNA CTD PMID:25596134 NCBI chr12:51,948,650...52,055,274
Ensembl chr12:51,948,650...52,055,271
JBrowse link
G Eprs glutamyl-prolyl-tRNA synthetase increases expression EXP Metformin results in increased expression of EPRS mRNA CTD PMID:25596134 NCBI chr13:103,300,911...103,371,651
Ensembl chr13:103,300,932...103,371,577
JBrowse link
G Eqtn equatorin multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of EQTN mRNA] CTD PMID:29095437 NCBI chr 5:113,852,191...113,881,142
Ensembl chr 5:113,871,230...113,880,911
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression EXP Metformin results in decreased expression of ERBB3 mRNA CTD PMID:31324951 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
JBrowse link
G Esr1 estrogen receptor 1 multiple interactions ISO
EXP
Metformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]]
Metformin inhibits the reaction [Testosterone results in increased expression of ESR1 mRNA]
CTD PMID:22132214, PMID:26492952 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
JBrowse link
G Esr2 estrogen receptor 2 multiple interactions EXP Metformin inhibits the reaction [Testosterone results in decreased expression of ESR2 mRNA] CTD PMID:26492952 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
JBrowse link
G Esrra estrogen related receptor, alpha multiple interactions
decreases expression
ISO Metformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA]
Metformin results in decreased expression of ESRRA mRNA
CTD PMID:23166782 NCBI chr 1:222,168,729...222,178,842
Ensembl chr 1:222,168,730...222,178,725
JBrowse link
G Faap20 FA core complex associated protein 20 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of FAAP20 mRNA] CTD PMID:29095437 NCBI chr 5:172,648,171...172,655,576
Ensembl chr 5:172,648,950...172,655,576
JBrowse link
G Fabp2 fatty acid binding protein 2 decreases expression EXP Metformin results in decreased expression of FABP2 mRNA CTD PMID:19022234 NCBI chr 2:227,080,912...227,083,654
Ensembl chr 2:227,080,924...227,083,501
JBrowse link
G Fabp3 fatty acid binding protein 3 increases expression EXP Metformin results in increased expression of FABP3 mRNA CTD PMID:25596134 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link
G Fabp7 fatty acid binding protein 7 increases expression EXP Metformin results in increased expression of FABP7 mRNA CTD PMID:31324951 NCBI chr20:40,769,624...40,773,156
Ensembl chr20:40,769,586...40,773,349
JBrowse link
G Fam149a family with sequence similarity 149, member A decreases expression EXP Metformin results in decreased expression of FAM149A mRNA CTD PMID:31324951 NCBI chr16:50,049,816...50,105,962
Ensembl chr16:50,049,828...50,107,856
JBrowse link
G Fam210a family with sequence similarity 210, member A increases expression EXP Metformin results in increased expression of FAM210A mRNA CTD PMID:25596134 NCBI chr18:64,045,023...64,084,594
Ensembl chr18:64,045,432...64,084,556
JBrowse link
G Fam214a family with sequence similarity 214, member A decreases expression EXP Metformin results in decreased expression of FAM214A mRNA CTD PMID:25596134 NCBI chr 8:81,863,619...81,941,548
Ensembl chr 8:81,863,619...81,941,536
JBrowse link
G Fam32a family with sequence similarity 32, member A decreases expression EXP Metformin results in decreased expression of FAM32A mRNA CTD PMID:25596134 NCBI chr16:19,304,522...19,308,842
Ensembl chr16:19,304,529...19,308,842
JBrowse link
G Fas Fas cell surface death receptor affects expression EXP Metformin affects the expression of FAS mRNA CTD PMID:25596134 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
JBrowse link
G Fasn fatty acid synthase decreases expression
increases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of FASN mRNA
Metformin results in increased expression of FASN mRNA
[Metformin co-treated with caffeic acid] results in decreased expression of FASN protein
CTD PMID:20956498, PMID:21870829, PMID:28576465, PMID:31324951 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression EXP Metformin results in decreased expression of FBP1 mRNA CTD PMID:19022234 NCBI chr17:396,175...417,480
Ensembl chr17:396,180...417,480
JBrowse link
G Fbxo22 F-box protein 22 increases expression EXP Metformin results in increased expression of FBXO22 mRNA CTD PMID:25596134 NCBI chr 8:59,770,032...59,786,061
Ensembl chr 8:59,769,994...59,786,065
JBrowse link
G Fbxo30 F-box protein 30 increases expression EXP Metformin results in increased expression of FBXO30 mRNA CTD PMID:25596134 NCBI chr 1:5,366,119...5,389,774
Ensembl chr 1:5,366,379...5,388,069
JBrowse link
G Fbxo32 F-box protein 32 decreases expression EXP Metformin results in decreased expression of FBXO32 mRNA CTD PMID:31324951 NCBI chr 7:98,065,664...98,098,071
Ensembl chr 7:98,063,735...98,098,268
JBrowse link
G Fech ferrochelatase decreases expression EXP Metformin results in decreased expression of FECH mRNA CTD PMID:25596134 NCBI chr18:59,941,992...59,975,192
Ensembl chr18:59,941,992...59,975,192
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA] CTD PMID:26497364 NCBI chr18:32,273,830...32,359,831
Ensembl chr18:32,273,770...32,359,824
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases expression EXP Metformin results in decreased expression of FGR mRNA CTD PMID:25596134 NCBI chr 5:151,172,189...151,199,746
Ensembl chr 5:151,172,206...151,199,745
JBrowse link
G Ficd FIC domain protein adenylyltransferase increases expression EXP Metformin results in increased expression of FICD mRNA CTD PMID:31324951 NCBI chr12:48,658,283...48,663,175
Ensembl chr12:48,658,283...48,663,143
JBrowse link
G Fis1 fission, mitochondrial 1 multiple interactions EXP Metformin inhibits the reaction [Glucose results in increased expression of FIS1 protein] CTD PMID:30144576 NCBI chr12:22,750,485...22,765,324
Ensembl chr12:22,750,485...22,765,308
JBrowse link
G Fkbp1a FKBP prolyl isomerase 1A multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of FKBP1A mRNA CTD PMID:29309887 NCBI chr 3:147,042,944...147,062,725
Ensembl chr 3:147,042,944...147,062,724
JBrowse link
G Flvcr2 FLVCR heme transporter 2 increases expression EXP Metformin results in increased expression of FLVCR2 mRNA CTD PMID:25596134, PMID:31324951 NCBI chr 6:109,617,348...109,681,495
Ensembl chr 6:109,617,355...109,681,495
JBrowse link
G Fmo3 flavin containing dimethylaniline monoxygenase 3 decreases expression EXP Metformin results in decreased expression of FMO3 mRNA CTD PMID:31324951 NCBI chr13:80,837,418...80,856,214
Ensembl chr13:80,837,420...80,862,963
JBrowse link
G Fn1 fibronectin 1 multiple interactions EXP
ISO
Metformin inhibits the reaction [Dietary Fats results in increased expression of FN1 protein]
Metformin inhibits the reaction [Folic Acid results in increased expression of FN1 mRNA]; Metformin inhibits the reaction [Folic Acid results in increased expression of FN1 protein]
CTD PMID:27551045, PMID:29380373 NCBI chr 9:78,900,111...78,969,018
Ensembl chr 9:78,900,103...78,969,078
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions
decreases expression
ISO
EXP
Metformin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of FOS protein]
Metformin results in decreased expression of FOS mRNA
CTD PMID:20590612, PMID:31324951 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Foxa2 forkhead box A2 multiple interactions ISO [Metformin co-treated with Glucose] affects the localization of FOXA2 protein CTD PMID:16489446 NCBI chr 3:142,383,084...142,387,493
Ensembl chr 3:142,383,278...142,387,481
JBrowse link
G Foxo1 forkhead box O1 decreases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of FOXO1 mRNA
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein]
CTD PMID:24428821, PMID:27270450 NCBI chr 2:141,451,234...141,527,016
Ensembl chr 2:141,451,234...141,527,016
JBrowse link
G Foxo3 forkhead box O3 decreases expression EXP Metformin results in decreased expression of FOXO3 mRNA CTD PMID:31324951 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions EXP Metformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CCNE1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CYP19A1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]; Metformin inhibits the reaction [FSHB protein results in increased secretion of Estradiol]; Metformin inhibits the reaction [FSHB protein results in increased secretion of Progesterone]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSHB protein results in increased phosphorylation of PRKAA1 protein]] CTD PMID:16760380 NCBI chr 3:98,088,321...98,092,131
Ensembl chr 3:98,088,324...98,092,131
JBrowse link
G Fut4 fucosyltransferase 4 increases expression ISO Metformin results in increased expression of FUT4 protein CTD PMID:26036281 NCBI chr 8:13,258,768...13,262,729
Ensembl chr 8:13,258,768...13,262,729
JBrowse link
G G0s2 G0/G1switch 2 increases expression EXP Metformin results in increased expression of G0S2 mRNA CTD PMID:31324951 NCBI chr13:112,004,140...112,005,052
Ensembl chr13:112,004,140...112,005,052
JBrowse link
G G6pc glucose-6-phosphatase, catalytic subunit multiple interactions
decreases expression
EXP
ISO
Metformin inhibits the reaction [Glucose results in increased expression of G6PC mRNA]
Metformin results in decreased expression of G6PC mRNA
CTD PMID:19576170, PMID:19664596, PMID:24428821, PMID:31324951 NCBI chr10:89,286,009...89,296,213
Ensembl chr10:89,285,855...89,296,213
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases expression EXP Metformin results in increased expression of G6PD mRNA CTD PMID:31324951 NCBI chr  X:156,274,800...156,293,935
Ensembl chr  X:156,274,800...156,293,926
JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha increases expression ISO
EXP
Metformin results in increased expression of GADD45A mRNA CTD PMID:19022234, PMID:25596134 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
JBrowse link
G Gars glycyl-tRNA synthetase increases expression EXP Metformin results in increased expression of GARS mRNA CTD PMID:25596134 NCBI chr 4:85,235,122...85,276,085
Ensembl chr 4:85,235,172...85,276,044
JBrowse link
G Gbe1 1,4-alpha-glucan branching enzyme 1 increases expression EXP Metformin results in increased expression of GBE1 mRNA CTD PMID:25596134 NCBI chr11:7,210,169...7,485,895
Ensembl chr11:7,210,209...7,485,890
JBrowse link
G Gbp1 guanylate binding protein 1 decreases expression EXP Metformin results in decreased expression of GBP1 mRNA CTD PMID:31324951 NCBI chr 2:248,343,334...248,423,402
Ensembl chr 2:248,398,917...248,409,570
JBrowse link
G Gcg glucagon multiple interactions EXP
ISO
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]; Metformin inhibits the reaction [GCG results in increased abundance of Glucose]
[Metformin co-treated with GCG] results in increased expression of IL1RN mRNA; Metformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]; Metformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA]
CTD PMID:19002567, PMID:22117073, PMID:23166782, PMID:27270450 NCBI chr 3:48,442,635...48,451,650
Ensembl chr 3:48,442,635...48,451,650
JBrowse link
G Gck glucokinase affects expression EXP Metformin affects the expression of GCK mRNA CTD PMID:31324951 NCBI chr14:86,149,146...86,191,589
Ensembl chr14:86,148,928...86,190,659
JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression EXP Metformin results in increased expression of GCLC mRNA CTD PMID:25596134 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit decreases expression
increases expression
EXP
ISO
Metformin results in decreased expression of GCLM mRNA
Metformin results in increased expression of GCLM mRNA
CTD PMID:25596134 NCBI chr 2:225,827,504...225,847,876
Ensembl chr 2:225,827,504...225,847,874
JBrowse link
G Gcnt3 glucosaminyl (N-acetyl) transferase 3, mucin type increases expression
multiple interactions
ISO
EXP
Metformin results in increased expression of GCNT3 mRNA
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of GCNT3 mRNA]
CTD PMID:25596134, PMID:29095437 NCBI chr 8:76,449,078...76,459,431
Ensembl chr 8:76,449,081...76,452,554
JBrowse link
G Gdf15 growth differentiation factor 15 increases expression EXP Metformin results in increased expression of GDF15 mRNA CTD PMID:25596134 NCBI chr16:20,555,395...20,557,978
Ensembl chr16:20,555,395...20,557,978
JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] CTD PMID:32652086 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
JBrowse link
G Ghrl ghrelin and obestatin prepropeptide multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of GHRL protein] CTD PMID:32652086 NCBI chr 4:145,674,157...145,678,066
Ensembl chr 4:145,674,157...145,678,066
JBrowse link
G Ghsr growth hormone secretagogue receptor multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA] CTD PMID:32652086 NCBI chr 2:113,065,953...113,071,265
Ensembl chr 2:113,066,885...113,070,261
JBrowse link
G Gimd1 GIMAP family P-loop NTPase domain containing 1 increases expression EXP Metformin results in increased expression of GIMD1 mRNA CTD PMID:31324951 NCBI chr 2:237,679,672...237,714,434
Ensembl chr 2:237,679,792...237,714,428
JBrowse link
G Gls glutaminase decreases expression ISO Metformin results in decreased expression of GLS protein CTD PMID:28576465 NCBI chr 9:54,212,622...54,284,879
Ensembl chr 9:54,212,767...54,284,872
JBrowse link
G Gmppb GDP-mannose pyrophosphorylase B increases expression EXP Metformin results in increased expression of GMPPB mRNA CTD PMID:31324951 NCBI chr 8:116,826,251...116,856,159
Ensembl chr 8:116,826,680...116,856,159
JBrowse link
G Gmpr guanosine monophosphate reductase decreases expression ISO Metformin results in decreased expression of GMPR mRNA CTD PMID:23457588 NCBI chr17:19,543,274...19,580,929
Ensembl chr17:19,543,275...19,580,929
JBrowse link
G Gnmt glycine N-methyltransferase decreases expression EXP Metformin results in decreased expression of GNMT mRNA CTD PMID:31324951 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link
G Golph3l golgi phosphoprotein 3-like increases expression EXP Metformin results in increased expression of GOLPH3L mRNA CTD PMID:31324951 NCBI chr 2:197,720,259...197,749,060
Ensembl chr 2:197,715,761...197,750,115
JBrowse link
G Got1 glutamic-oxaloacetic transaminase 1 decreases expression EXP Metformin results in decreased expression of GOT1 mRNA CTD PMID:25596134, PMID:31324951 NCBI chr 1:263,246,248...263,269,762
Ensembl chr 1:263,246,248...263,269,762
JBrowse link
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial increases expression EXP Metformin results in increased expression of GPAM mRNA CTD PMID:31324951 NCBI chr 1:275,843,823...275,906,880
Ensembl chr 1:275,846,819...275,906,686
JBrowse link
G Gpat3 glycerol-3-phosphate acyltransferase 3 increases expression ISO Metformin results in increased expression of GPAT3 mRNA CTD PMID:25596134 NCBI chr14:10,343,287...10,396,565
Ensembl chr14:10,343,282...10,395,047
JBrowse link
G Gphn gephyrin increases expression EXP Metformin results in increased expression of GPHN mRNA CTD PMID:25596134 NCBI chr 6:101,327,874...101,859,169
Ensembl chr 6:101,532,518...101,859,164
JBrowse link
G Gpihbp1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 increases expression EXP Metformin results in increased expression of GPIHBP1 mRNA CTD PMID:31324951 NCBI chr 7:116,632,496...116,635,543
Ensembl chr 7:116,632,506...116,634,293
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Metformin results in increased expression of GPNMB mRNA CTD PMID:25596134 NCBI chr 4:78,694,447...78,715,685
Ensembl chr 4:78,694,447...78,715,683
JBrowse link
G Gpr22 G protein-coupled receptor 22 decreases expression EXP Metformin results in decreased expression of GPR22 mRNA CTD PMID:31324951 NCBI chr 6:51,012,421...51,021,253
Ensembl chr 6:51,011,426...51,019,407
JBrowse link
G Gprin3 GPRIN family member 3 increases expression EXP Metformin results in increased expression of GPRIN3 mRNA CTD PMID:31324951 NCBI chr 4:89,690,678...89,778,302
Ensembl chr 4:89,693,280...89,695,928
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO
EXP
Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein]; Metformin inhibits the reaction [Acetaminophen results in increased expression of and results in increased secretion of and results in increased activity of GPT protein]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased activity of GPT protein]
CTD PMID:24717679, PMID:27562556, PMID:29614383, PMID:31743741 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta increases phosphorylation
multiple interactions
ISO
EXP
Metformin results in increased phosphorylation of GSK3B protein
Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [Methamphetamine results in increased expression of and results in increased phosphorylation of GSK3B protein]
Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]
CTD PMID:21054339, PMID:30742852, PMID:30928401, PMID:31877369 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Gsn gelsolin increases expression ISO Metformin results in increased expression of GSN mRNA CTD PMID:19022234 NCBI chr 3:14,456,106...14,508,922
Ensembl chr 3:14,467,330...14,508,911
JBrowse link
G Gspt1 G1 to S phase transition 1 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of GSPT1 mRNA] CTD PMID:29095437 NCBI chr10:4,313,100...4,347,661
Ensembl chr10:4,312,863...4,446,200
JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions
affects expression
ISO
EXP
Metformin inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein]
Metformin inhibits the reaction [Methamphetamine results in decreased activity of GSR protein]
Metformin affects the expression of GSR mRNA
CTD PMID:24717679, PMID:25596134, PMID:30742852 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
JBrowse link
G Gsta1 glutathione S-transferase alpha 1 multiple interactions EXP Metformin inhibits the reaction [Doxorubicin results in increased expression of GSTA1 mRNA] CTD PMID:22666520 NCBI chr 9:27,366,404...27,381,004
Ensembl chr 9:27,368,272...27,452,902
JBrowse link
G Gstm2 glutathione S-transferase mu 2 decreases expression EXP Metformin results in decreased expression of GSTM2 mRNA CTD PMID:31324951 NCBI chr 2:210,778,041...210,782,807
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstm7 glutathione S-transferase, mu 7 decreases expression EXP Metformin results in decreased expression of GSTM7 mRNA CTD PMID:31324951 NCBI chr 2:210,720,719...210,726,179
Ensembl chr 2:210,720,704...210,782,856
JBrowse link
G Gstp1 glutathione S-transferase pi 1 increases expression EXP Metformin results in increased expression of GSTP1 mRNA CTD PMID:19022234 NCBI chr 1:219,291,679...219,294,147
Ensembl chr 1:219,291,679...219,294,147
JBrowse link
G H1f2 H1.2 linker histone, cluster member decreases expression ISO Metformin results in decreased expression of H1-2 mRNA CTD PMID:25596134 NCBI chr17:43,638,938...43,640,445
Ensembl chr17:43,639,749...43,640,387
JBrowse link
G H2ax H2A.X variant histone decreases expression
increases expression
multiple interactions
ISO Metformin results in decreased expression of H2AX protein
Metformin results in increased expression of H2AX mRNA
[epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA
CTD PMID:23363784, PMID:29117515 NCBI chr 8:48,665,652...48,666,981
Ensembl chr 8:48,665,652...48,666,981
JBrowse link
G Hal histidine ammonia lyase decreases expression EXP Metformin results in decreased expression of HAL mRNA CTD PMID:31324951 NCBI chr 7:34,326,087...34,356,413
Ensembl chr 7:34,326,087...34,356,413
JBrowse link
G Hamp hepcidin antimicrobial peptide decreases expression EXP Metformin results in decreased expression of HAMP mRNA CTD PMID:31324951 NCBI chr 1:89,368,021...89,369,960
Ensembl chr 1:89,368,021...89,369,960
JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; Metformin promotes the reaction [2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]] CTD PMID:30551545 NCBI chr10:31,813,819...31,860,934
Ensembl chr10:31,813,814...31,848,379
JBrowse link
G Hbb hemoglobin subunit beta decreases expression EXP Metformin results in decreased expression of HBB-B1 mRNA CTD PMID:31324951 NCBI chr 1:168,971,269...168,972,680
Ensembl chr 1:168,971,274...168,972,725
JBrowse link
G Hbb-bs hemoglobin, beta adult s chain decreases expression EXP Metformin results in decreased expression of HBB-BS mRNA CTD PMID:31324951 NCBI chr 1:168,964,202...168,965,568
Ensembl chr 1:168,945,449...168,965,566
JBrowse link
G Heatr6 HEAT repeat containing 6 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HEATR6 mRNA] CTD PMID:29095437 NCBI chr10:71,054,344...71,083,229
Ensembl chr10:71,054,344...71,083,536
JBrowse link
G Hemgn hemogen decreases expression EXP Metformin results in decreased expression of HEMGN mRNA CTD PMID:31324951 NCBI chr 5:62,004,271...62,025,075
Ensembl chr 5:62,005,071...62,025,152
JBrowse link
G Herc3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 decreases expression EXP Metformin results in decreased expression of HERC3 mRNA CTD PMID:25596134 NCBI chr 4:89,078,670...89,169,150
Ensembl chr 4:89,078,711...89,169,146
JBrowse link
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 increases expression EXP Metformin results in increased expression of HERPUD1 mRNA CTD PMID:31324951 NCBI chr19:11,046,905...11,057,440
Ensembl chr19:11,046,909...11,057,254
JBrowse link
G Hhex hematopoietically expressed homeobox decreases expression EXP Metformin results in decreased expression of HHEX mRNA CTD PMID:31324951 NCBI chr 1:256,101,994...256,107,581
Ensembl chr 1:256,101,903...256,107,649
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha affects activity
multiple interactions
decreases expression
EXP
ISO
Metformin affects the activity of HIF1A protein
[Metformin co-treated with Pioglitazone] results in decreased expression of HIF1A mRNA
Metformin results in decreased expression of HIF1A mRNA
CTD PMID:25596134, PMID:32589349 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hist2h3c2 histone cluster 2 H3 family member C2 increases expression EXP Metformin results in increased expression of HIST2H3C2 mRNA CTD PMID:31324951 NCBI chr 2:198,390,024...198,418,075
Ensembl chr 2:198,417,619...198,418,029
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO [Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein] CTD PMID:25412314 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase decreases expression
increases expression
multiple interactions
ISO
EXP
Metformin results in decreased expression of HMGCR mRNA
Metformin results in increased expression of HMGCR mRNA
Metformin inhibits the reaction [AGT protein results in increased activity of and results in increased phosphorylation of HMGCR protein]
CTD PMID:21870829, PMID:29499335, PMID:31324951 NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
JBrowse link
G Hmox1 heme oxygenase 1 increases expression
decreases expression
multiple interactions
decreases response to substance
ISO
EXP
Metformin results in increased expression of HMOX1 mRNA
Metformin results in decreased expression of HMOX1 mRNA; Metformin results in decreased expression of HMOX1 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Metformin results in decreased expression of HMOX1 protein]
HMOX1 protein results in decreased susceptibility to Metformin
Metformin inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA]
CTD PMID:19022234, PMID:21457706, PMID:22666520, PMID:23707609, PMID:25596134 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
JBrowse link
G Hnf4a hepatocyte nuclear factor 4, alpha decreases expression EXP
ISO
Metformin results in decreased expression of HNF4A mRNA
Metformin results in decreased expression of HNF4A mRNA; Metformin results in decreased expression of HNF4A protein
CTD PMID:19022234, PMID:24428821 NCBI chr 3:159,902,441...159,965,003
Ensembl chr 3:159,902,441...159,965,003
JBrowse link
G Hnrnpk heterogeneous nuclear ribonucleoprotein K multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of HNRNPK mRNA CTD PMID:29309887 NCBI chr17:6,664,730...6,676,753
Ensembl chr17:6,665,659...6,676,654
JBrowse link
G Hook2 hook microtubule-tethering protein 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HOOK2 mRNA] CTD PMID:29095437 NCBI chr19:26,106,713...26,119,353
Ensembl chr19:26,106,838...26,119,352
JBrowse link
G Hras HRas proto-oncogene, GTPase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of HRAS mRNA CTD PMID:29309887 NCBI chr 1:214,178,404...214,181,841
Ensembl chr 1:214,178,407...214,181,686
JBrowse link
G Hrh2 histamine receptor H 2 multiple interactions ISO [Cimetidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Ranitidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin CTD PMID:16632449 NCBI chr17:10,912,959...10,931,389
Ensembl chr17:10,921,507...10,952,441
JBrowse link
G Hsc70-ps1 heat shock cognate protein 70, pseudogene 1 increases expression EXP Metformin results in increased expression of HSC70-PS1 mRNA CTD PMID:31324951 NCBI chr 2:177,651,231...177,653,349 JBrowse link
G Hsc70-ps2 heat shock cognate protein 70, pseudogene 2 increases expression EXP Metformin results in increased expression of HSC70-PS2 mRNA CTD PMID:31324951 NCBI chr18:17,116,401...17,118,671 JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression EXP Metformin results in increased expression of HSPA5 mRNA CTD PMID:25596134 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Hsph1 heat shock protein family H (Hsp110) member 1 increases expression EXP Metformin results in increased expression of HSPH1 mRNA CTD PMID:31324951 NCBI chr12:6,322,685...6,341,898
Ensembl chr12:6,322,668...6,341,902
JBrowse link
G Htatip2 HIV-1 Tat interactive protein 2 increases expression EXP Metformin results in increased expression of HTATIP2 mRNA CTD PMID:25596134 NCBI chr 1:105,094,272...105,109,459
Ensembl chr 1:105,094,411...105,109,461
JBrowse link
G Hykk hydroxylysine kinase decreases expression EXP Metformin results in decreased expression of HYKK mRNA CTD PMID:31324951 NCBI chr 8:59,507,975...59,531,745
Ensembl chr 8:59,507,990...59,529,366
JBrowse link
G Hyou1 hypoxia up-regulated 1 increases expression EXP Metformin results in increased expression of HYOU1 mRNA CTD PMID:31324951 NCBI chr 8:48,699,796...48,711,912
Ensembl chr 8:48,699,769...48,711,910
JBrowse link
G Iars1 isoleucyl-tRNA synthetase 1 increases expression EXP Metformin results in increased expression of IARS mRNA; Metformin results in increased expression of IARS1 mRNA CTD PMID:25596134, PMID:31324951 NCBI chr17:15,356,016...15,402,680
Ensembl chr17:15,355,529...15,402,649
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions EXP Metformin inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form] CTD PMID:25108154 NCBI chr 8:22,035,287...22,047,049
Ensembl chr 8:22,035,256...22,047,059
JBrowse link
G Idi1 isopentenyl-diphosphate delta isomerase 1 increases expression EXP Metformin results in increased expression of IDI1 mRNA CTD PMID:31324951 NCBI chr17:57,976,266...57,984,036
Ensembl chr17:57,976,268...57,984,036
JBrowse link
G Ifitm3 interferon induced transmembrane protein 3 decreases expression EXP Metformin results in decreased expression of IFITM3 mRNA CTD PMID:31324951 NCBI chr 1:213,810,712...213,811,821
Ensembl chr 1:213,810,696...213,811,901
JBrowse link
G Ifng interferon gamma increases expression
multiple interactions
ISO Metformin results in increased expression of IFNG protein
[Paclitaxel co-treated with Metformin] results in increased expression of IFNG mRNA
CTD PMID:20869956, PMID:29309887 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
JBrowse link
G Igf1 insulin-like growth factor 1 multiple interactions ISO
EXP
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with Pioglitazone] results in decreased expression of IGF1 mRNA
Metformin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA]
Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]
CTD PMID:21664031, PMID:23927877, PMID:26492952, PMID:26497364, PMID:32589349 NCBI chr 7:28,412,123...28,491,815
Ensembl chr 7:28,412,198...28,486,609
JBrowse link
G Igf1r insulin-like growth factor 1 receptor multiple interactions ISO
EXP
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNA
Metformin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]
CTD PMID:21664031, PMID:26492952 NCBI chr 1:128,924,921...129,213,816
Ensembl chr 1:128,924,966...129,206,516
JBrowse link
G Igf2 insulin-like growth factor 2 multiple interactions ISO [Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 protein CTD PMID:21664031 NCBI chr 1:215,828,102...215,839,081
Ensembl chr 1:215,828,102...215,846,911
JBrowse link
G Igf2r insulin-like growth factor 2 receptor multiple interactions
increases expression
ISO
EXP
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF2R mRNA
Metformin results in increased expression of IGF2R mRNA
CTD PMID:21664031, PMID:25596134 NCBI chr 1:48,176,095...48,264,482
Ensembl chr 1:48,176,106...48,264,477
JBrowse link
G Igfbp1 insulin-like growth factor binding protein 1 decreases expression ISO
EXP
Metformin results in decreased expression of IGFBP1 mRNA CTD PMID:21316309, PMID:31324951 NCBI chr14:87,448,716...87,453,783
Ensembl chr14:87,448,692...87,453,785
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of IKBKB mRNA CTD PMID:29309887 NCBI chr16:74,177,233...74,230,809
Ensembl chr16:74,177,215...74,230,815
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of ARG1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL24 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL7 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CHIL3 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CXCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MGL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP9 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]; Metformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of RETNLA mRNA] CTD PMID:26497364 NCBI chr10:38,982,909...38,985,466
Ensembl chr10:38,982,909...38,985,466
JBrowse link
G Il15ra interleukin 15 receptor subunit alpha multiple interactions
decreases expression
ISO [Metformin co-treated with Cyclic AMP] results in decreased expression of IL15RA mRNA; Metformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA]
Metformin results in decreased expression of IL15RA mRNA
CTD PMID:22117073 NCBI chr17:70,451,861...70,481,838
Ensembl chr17:70,451,411...70,481,750
JBrowse link
G Il17rb interleukin 17 receptor B decreases expression EXP Metformin results in decreased expression of IL17RB mRNA CTD PMID:25596134 NCBI chr16:6,064,287...6,077,978
Ensembl chr16:6,064,288...6,077,978
JBrowse link
G Il1b interleukin 1 beta multiple interactions
increases expression
ISO
EXP
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK10 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK9 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Metformin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]; Metformin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Metformin inhibits the reaction [Methamphetamine results in increased expression of IL1B protein]
Metformin inhibits the reaction [IL13 protein results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL1B protein]
Metformin results in increased expression of IL1B mRNA
CTD PMID:16385087, PMID:21316309, PMID:26497364, PMID:27551045, PMID:27634381, PMID:28259689, PMID:30742852 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il1rn interleukin 1 receptor antagonist multiple interactions
increases expression
ISO [Metformin co-treated with GCG] results in increased expression of IL1RN mRNA; Cyclic AMP promotes the reaction [Metformin results in increased expression of IL1RN mRNA]; Metformin promotes the reaction [Cyclic AMP results in increased expression of IL1RN mRNA] CTD PMID:22117073 NCBI chr 3:1,449,778...1,468,624
Ensembl chr 3:1,452,644...1,468,614
JBrowse link
G Il33 interleukin 33 decreases expression EXP Metformin results in decreased expression of IL33 mRNA CTD PMID:31324951 NCBI chr 1:248,112,611...248,147,030
Ensembl chr 1:248,132,090...248,147,029
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
increases expression
ISO
EXP
Metformin results in decreased expression of IL6 mRNA
Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]; Metformin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]
3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; Metformin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of IL6 protein]
Metformin results in increased expression of IL6 mRNA; Metformin results in increased expression of IL6 protein
Metformin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]
CTD PMID:16385087, PMID:20869956, PMID:20956498, PMID:21457706, PMID:21870829, PMID:24717679, PMID:24842192, PMID:25108154, PMID:27634381, PMID:28096963, PMID:29859833, PMID:32652086 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Inmt indolethylamine N-methyltransferase decreases expression EXP Metformin results in decreased expression of INMT mRNA CTD PMID:31324951 NCBI chr 4:85,381,907...85,386,203
Ensembl chr 4:85,381,889...85,386,231
JBrowse link
G Ins2 insulin 2 multiple interactions
increases expression
decreases expression
ISO [Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in increased phosphorylation of AKT1 protein; Metformin inhibits the reaction [[Glucose affects the susceptibility to INS protein] which affects the uptake of Glucose]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of PTPN1 protein]; Metformin promotes the reaction [Glucose results in increased secretion of INS protein]; Metformin results in decreased expression of and results in decreased secretion of INS protein; Metformin results in increased expression of and results in increased secretion of INS protein
Metformin results in increased expression of INS mRNA
Metformin results in decreased expression of INS protein
CTD PMID:1900072, PMID:15531508, PMID:18082302, PMID:21664031, PMID:21779873, PMID:30914352, PMID:30928401 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Insig1 insulin induced gene 1 increases expression ISO Metformin results in increased expression of INSIG1 mRNA CTD PMID:23457588 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insig2 insulin induced gene 2 decreases expression EXP Metformin results in decreased expression of INSIG2 mRNA CTD PMID:25596134 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link
G Insr insulin receptor multiple interactions ISO [Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNA
Metformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]
CTD PMID:21664031, PMID:23927877 NCBI chr12:1,682,527...1,816,414
Ensembl chr12:1,680,957...1,816,414
JBrowse link
G Irf2bp2 interferon regulatory factor 2 binding protein 2 decreases expression EXP Metformin results in decreased expression of IRF2BP2 mRNA CTD PMID:31324951 NCBI chr19:59,497,021...59,502,298
Ensembl chr19:59,499,876...59,502,161
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of IRF3 mRNA CTD PMID:29309887 NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
JBrowse link
G Irf5 interferon regulatory factor 5 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of IRF5 mRNA CTD PMID:29309887 NCBI chr 4:56,804,477...56,816,271
Ensembl chr 4:56,805,132...56,820,543
JBrowse link
G Irf7 interferon regulatory factor 7 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of IRF7 mRNA CTD PMID:29309887 NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
JBrowse link
G Irs1 insulin receptor substrate 1 multiple interactions ISO
EXP
Metformin affects the reaction [Testosterone results in decreased expression of IRS1]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]
Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein]
Metformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]; Metformin promotes the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of IRS1 protein]
CTD PMID:19328476, PMID:23927877, PMID:27634381, PMID:30914352, PMID:30928401, PMID:31743741 NCBI chr 9:88,033,668...88,086,488
Ensembl chr 9:88,033,668...88,086,488
JBrowse link
G Irs2 insulin receptor substrate 2 decreases expression EXP Metformin results in decreased expression of IRS2 mRNA CTD PMID:31324951 NCBI chr16:83,824,515...83,848,569
Ensembl chr16:83,824,430...83,848,684
JBrowse link
G Iscu iron-sulfur cluster assembly enzyme affects expression EXP Metformin affects the expression of ISCU mRNA CTD PMID:25596134 NCBI chr12:48,621,454...48,627,297
Ensembl chr12:48,621,454...48,627,297
JBrowse link
G Itgb1 integrin subunit beta 1 increases expression EXP Metformin results in increased expression of ITGB1 mRNA CTD PMID:25596134 NCBI chr19:61,677,512...61,725,537
Ensembl chr19:61,677,542...61,725,535
JBrowse link
G Itgb8 integrin subunit beta 8 increases expression EXP Metformin results in increased expression of ITGB8 mRNA CTD PMID:31324951 NCBI chr 6:147,089,280...147,172,846
Ensembl chr 6:147,094,097...147,172,813
JBrowse link
G Itpr2 inositol 1,4,5-trisphosphate receptor, type 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ITPR2 mRNA] CTD PMID:29095437 NCBI chr 4:180,423,452...180,800,088
Ensembl chr 4:180,538,389...180,722,358
JBrowse link
G Jkamp JNK1/MAPK8-associated membrane protein multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of JKAMP mRNA] CTD PMID:29095437 NCBI chr 6:94,835,845...94,849,784
Ensembl chr 6:94,835,845...94,849,784
JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Metformin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein] CTD PMID:20590612 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
JBrowse link
G Junb JunB proto-oncogene, AP-1 transcription factor subunit decreases expression EXP Metformin results in decreased expression of JUNB mRNA CTD PMID:31324951 NCBI chr19:26,092,972...26,094,756
Ensembl chr19:26,092,974...26,094,756
JBrowse link
G Jund JunD proto-oncogene, AP-1 transcription factor subunit increases expression ISO Metformin results in increased expression of JUND mRNA CTD PMID:19022234 NCBI chr16:20,485,028...20,486,707
Ensembl chr16:20,485,029...20,486,707
JBrowse link
G Kbtbd12 kelch repeat and BTB domain containing 12 increases expression EXP Metformin results in increased expression of KBTBD12 mRNA CTD PMID:31324951 NCBI chr 4:120,492,541...120,567,755
Ensembl chr 4:120,551,599...120,559,078
JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 decreases expression EXP Metformin results in decreased expression of KEAP1 mRNA CTD PMID:25596134 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
JBrowse link
G Klf15 Kruppel-like factor 15 decreases expression ISO Metformin results in decreased expression of KLF15 mRNA CTD PMID:24428821 NCBI chr 4:122,364,688...122,377,690
Ensembl chr 4:122,365,093...122,377,659
JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression EXP Metformin results in decreased expression of KLF9 mRNA CTD PMID:31324951 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
JBrowse link
G Klhl33 kelch-like family member 33 decreases expression EXP Metformin results in decreased expression of KLHL33 mRNA CTD PMID:31324951 NCBI chr15:27,811,226...27,819,808
Ensembl chr15:27,813,393...27,815,261
JBrowse link
G Kras KRAS proto-oncogene, GTPase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of KRAS mRNA CTD PMID:29309887 NCBI chr 4:179,482,562...179,515,483
Ensembl chr 4:179,486,105...179,515,558
JBrowse link
G Krt19 keratin 19 increases expression EXP Metformin results in increased expression of KRT19 mRNA CTD PMID:25596134 NCBI chr10:88,055,843...88,060,560
Ensembl chr10:88,055,841...88,060,561
JBrowse link
G Krt80 keratin 80 increases expression ISO Metformin results in increased expression of KRT80 mRNA CTD PMID:21527772 NCBI chr 7:142,995,715...143,015,932
Ensembl chr 7:142,994,119...143,016,040
JBrowse link
G Lamc2 laminin subunit gamma 2 decreases expression EXP Metformin results in decreased expression of LAMC2 mRNA CTD PMID:31324951 NCBI chr13:70,566,643...70,632,126
Ensembl chr13:70,566,643...70,626,252
JBrowse link
G Lars1 leucyl-tRNA synthetase 1 increases expression EXP Metformin results in increased expression of LARS mRNA CTD PMID:25596134 NCBI chr18:36,524,013...36,579,471
Ensembl chr18:36,524,007...36,579,403
JBrowse link
G Lce1d late cornified envelope 1D multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of LCE1D mRNA] CTD PMID:29095437
G Lcn2 lipocalin 2 multiple interactions EXP Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein] CTD PMID:30551545 NCBI chr 3:11,414,189...11,417,534
Ensembl chr 3:11,414,186...11,417,546
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of LDLR protein]
Metformin inhibits the reaction [AGT protein results in increased expression of LDLR protein]; Metformin inhibits the reaction [Hydrogen Peroxide results in increased expression of LDLR protein]
CTD PMID:29499335 NCBI chr 8:22,750,425...22,773,305
Ensembl chr 8:22,750,336...22,774,903
JBrowse link
G Lep leptin increases expression
multiple interactions
ISO Metformin results in increased expression of LEP protein
Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein]
CTD PMID:20869956, PMID:32652086 NCBI chr 4:56,337,695...56,351,818
Ensembl chr 4:56,337,695...56,351,818
JBrowse link
G Lgals5 galectin 5 decreases expression EXP Metformin results in decreased expression of LGALS5 mRNA CTD PMID:31324951 NCBI chr10:66,226,015...66,229,293
Ensembl chr10:66,225,995...66,229,311
JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions EXP Metformin inhibits the reaction [Letrozole results in increased secretion of LHB protein] CTD PMID:32298659 NCBI chr 1:101,409,992...101,413,725
Ensembl chr 1:101,410,019...101,413,724
JBrowse link
G Lingo3 leucine rich repeat and Ig domain containing 3 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of LINGO3 mRNA CTD PMID:29309887 NCBI chr 7:11,737,293...11,746,703
Ensembl chr 7:11,737,293...11,746,703
JBrowse link
G Lmcd1 LIM and cysteine-rich domains 1 decreases expression EXP Metformin results in decreased expression of LMCD1 mRNA CTD PMID:25596134 NCBI chr 4:144,192,989...144,252,554
Ensembl chr 4:144,192,989...144,252,551
JBrowse link
G Lmna lamin A/C multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of LMNA mRNA] CTD PMID:29095437 NCBI chr 2:187,842,884...187,863,552
Ensembl chr 2:187,842,885...187,863,516
JBrowse link
G LOC100910669 paired immunoglobulin-like type 2 receptor alpha-like multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PILRA mRNA] CTD PMID:29095437 NCBI chr12:21,678,550...21,689,821
Ensembl chr12:21,678,580...21,690,678
JBrowse link
G Lox lysyl oxidase affects expression EXP Metformin affects the expression of LOX mRNA CTD PMID:31324951 NCBI chr18:47,500,320...47,577,819
Ensembl chr18:47,500,330...47,577,819
JBrowse link
G Lpar3 lysophosphatidic acid receptor 3 decreases expression EXP Metformin results in decreased expression of LPAR3 mRNA CTD PMID:31324951 NCBI chr 2:252,090,634...252,159,221
Ensembl chr 2:252,090,669...252,159,903
JBrowse link
G Lpin2 lipin 2 decreases expression EXP Metformin results in decreased expression of LPIN2 mRNA CTD PMID:31324951 NCBI chr 9:119,517,101...119,591,533
Ensembl chr 9:119,517,101...119,591,533
JBrowse link
G Lss lanosterol synthase increases expression EXP Metformin results in increased expression of LSS mRNA CTD PMID:31324951 NCBI chr20:12,844,522...12,870,474
Ensembl chr20:12,842,884...12,870,497
JBrowse link
G Ltn1 listerin E3 ubiquitin protein ligase 1 decreases expression EXP Metformin results in decreased expression of LTN1 mRNA CTD PMID:25596134 NCBI chr11:27,023,328...27,080,575
Ensembl chr11:27,022,986...27,080,701
JBrowse link
G Lurap1l leucine rich adaptor protein 1-like decreases expression EXP Metformin results in decreased expression of LURAP1L mRNA CTD PMID:31324951 NCBI chr 5:98,468,039...98,515,126
Ensembl chr 5:98,469,047...98,515,125
JBrowse link
G Lyst lysosomal trafficking regulator decreases expression EXP Metformin results in decreased expression of LYST mRNA CTD PMID:31324951 NCBI chr17:90,323,055...90,522,091 JBrowse link
G Mafg MAF bZIP transcription factor G increases expression EXP Metformin results in increased expression of MAFG mRNA CTD PMID:25596134 NCBI chr10:109,802,877...109,811,476
Ensembl chr10:109,806,159...109,811,323
JBrowse link
G Magohb mago homolog B, exon junction complex subunit increases expression EXP Metformin results in increased expression of MAGOHB mRNA CTD PMID:31324951 NCBI chr 4:165,514,584...165,522,366
Ensembl chr 4:165,514,530...165,522,418
JBrowse link
G Man1a2 mannosidase, alpha, class 1A, member 2 increases expression EXP Metformin results in increased expression of MAN1A2 mRNA CTD PMID:25596134 NCBI chr 2:202,891,537...203,043,847
Ensembl chr 2:202,891,537...203,043,847
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions ISO [Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form] CTD PMID:25412314 NCBI chr19:53,635,449...53,643,970
Ensembl chr19:53,629,779...53,646,058
JBrowse link
G Map2k3 mitogen activated protein kinase kinase 3 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of MAP2K3 mRNA CTD PMID:29309887 NCBI chr10:45,089,455...45,110,802
Ensembl chr10:47,182,433...47,203,753
JBrowse link
G Map3k2 mitogen activated protein kinase kinase kinase 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K2 mRNA CTD PMID:29309887 NCBI chr18:24,961,250...25,025,488
Ensembl chr18:24,961,245...25,025,897
JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K7 mRNA CTD PMID:29309887 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
JBrowse link
G Map4k2 mitogen activated protein kinase kinase kinase kinase 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of MAP4K2 mRNA] CTD PMID:29095437 NCBI chr 1:221,710,622...221,726,274
Ensembl chr 1:221,710,670...221,725,656
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
Metformin results in decreased phosphorylation of MAPK1 protein
PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein]
CTD PMID:16385087, PMID:16760380, PMID:20590612, PMID:23707609 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk10 mitogen activated protein kinase 10 multiple interactions ISO Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK10 protein] CTD PMID:16385087 NCBI chr14:8,079,955...8,371,508
Ensembl chr14:8,080,275...8,368,254
JBrowse link
G Mapk14 mitogen activated protein kinase 14 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of MAPK14 mRNA CTD PMID:29309887 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO
EXP
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
Metformin results in decreased phosphorylation of MAPK3 protein
PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein]
CTD PMID:16385087, PMID:16760380, PMID:20590612, PMID:23707609 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK9 protein] CTD PMID:16385087 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor increases expression EXP Metformin results in increased expression of MCM10 mRNA CTD PMID:31324951 NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478
JBrowse link
G Mctp2 multiple C2 and transmembrane domain containing 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MCTP2 mRNA] CTD PMID:29095437 NCBI chr 1:133,324,881...133,559,644
Ensembl chr 1:133,324,301...133,559,975
JBrowse link
G Mdm2 MDM2 proto-oncogene increases expression EXP Metformin results in increased expression of MDM2 mRNA CTD PMID:25596134 NCBI chr 7:60,719,060...60,743,618
Ensembl chr 7:60,719,066...60,743,328
JBrowse link
G Me1 malic enzyme 1 increases expression
decreases expression
EXP
ISO
Metformin results in increased expression of ME1 mRNA
Metformin results in decreased expression of ME1 protein
CTD PMID:25596134, PMID:28576465, PMID:31324951 NCBI chr 8:94,256,830...94,368,834
Ensembl chr 8:94,256,839...94,368,834
JBrowse link
G Med29 mediator complex subunit 29 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MED29 mRNA] CTD PMID:29095437 NCBI chr 1:85,368,288...85,373,691
Ensembl chr 1:85,368,288...85,373,099
JBrowse link
G Mef2a myocyte enhancer factor 2a increases expression ISO Metformin results in increased expression of MEF2A mRNA CTD PMID:15864539 NCBI chr 1:128,207,715...128,341,681
Ensembl chr 1:128,209,971...128,341,263
JBrowse link
G Mef2b myocyte enhancer factor 2B increases expression ISO Metformin results in increased expression of MEF2B mRNA CTD PMID:23457588 NCBI chr16:21,001,204...21,017,651
Ensembl chr16:21,001,206...21,017,163
JBrowse link
G Mef2c myocyte enhancer factor 2C increases expression ISO Metformin results in increased expression of MEF2C mRNA CTD PMID:15864539 NCBI chr 2:11,658,534...11,822,788
Ensembl chr 2:11,658,568...11,822,787
JBrowse link
G Mef2d myocyte enhancer factor 2D increases expression ISO Metformin results in increased expression of MEF2D mRNA CTD PMID:15864539 NCBI chr 2:187,511,775...187,541,285
Ensembl chr 2:187,512,164...187,538,026
JBrowse link
G Mettl1 methyltransferase like 1 increases expression EXP Metformin results in increased expression of METTL1 mRNA CTD PMID:31324951 NCBI chr 7:70,328,470...70,333,045
Ensembl chr 7:70,328,391...70,333,166
JBrowse link
G Mettl22 methyltransferase like 22 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of METTL22 mRNA] CTD PMID:29095437 NCBI chr10:7,223,351...7,240,822
Ensembl chr10:7,223,362...7,240,812
JBrowse link
G Mfn2 mitofusin 2 multiple interactions EXP Metformin inhibits the reaction [Glucose results in decreased expression of MFN2 protein] CTD PMID:30144576 NCBI chr 5:164,684,244...164,715,414
Ensembl chr 5:164,684,509...164,714,145
JBrowse link
G Mfsd2a major facilitator superfamily domain containing 2A affects expression EXP Metformin affects the expression of MFSD2A mRNA CTD PMID:31324951 NCBI chr 5:140,642,865...140,657,759
Ensembl chr 5:140,642,885...140,657,745
JBrowse link
G Mgat2 alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase increases expression EXP Metformin results in increased expression of MGAT2 mRNA CTD PMID:31324951 NCBI chr 6:91,476,698...91,479,187
Ensembl chr 6:91,476,698...91,479,183
JBrowse link
G Mid1ip1 MID1 interacting protein 1 increases expression EXP Metformin results in increased expression of MID1IP1 mRNA CTD PMID:31324951 NCBI chr  X:13,114,557...13,119,274
Ensembl chr  X:13,114,569...13,116,743
JBrowse link
G Mir1 microRNA 1 increases expression EXP Metformin results in increased expression of MIR1 mRNA CTD PMID:31324951 NCBI chr18:2,054,933...2,055,019 JBrowse link
G Mir146a microRNA 146a multiple interactions EXP Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of MIR146A mRNA] CTD PMID:30290168 NCBI chr10:28,962,476...28,962,570
Ensembl chr10:28,962,476...28,962,570
JBrowse link
G Mir155 microRNA 155 multiple interactions EXP Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in increased expression of MIR155 mRNA] CTD PMID:30290168 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
JBrowse link
G Mir15b microRNA 15b increases expression EXP Metformin results in increased expression of MIR15B mRNA CTD PMID:31324951 NCBI chr 2:165,605,923...165,606,020
Ensembl chr 2:165,605,923...165,606,020
JBrowse link
G Mir190 microRNA 190 decreases expression EXP Metformin results in decreased expression of MIR190 mRNA CTD PMID:31324951 NCBI chr 8:73,030,047...73,030,131
Ensembl chr 8:73,030,047...73,030,131
JBrowse link
G Mir290 microRNA 290 decreases expression EXP Metformin results in decreased expression of MIR292 mRNA CTD PMID:31324951 NCBI chr 1:64,538,705...64,538,785
Ensembl chr 1:64,538,705...64,538,785
JBrowse link
G Mir29b2 microRNA 29b-2 decreases expression EXP Metformin results in decreased expression of MIR29B2 mRNA CTD PMID:31324951 NCBI chr13:113,782,057...113,782,137
Ensembl chr13:113,782,057...113,782,140
JBrowse link
G Mir99b microRNA 99b multiple interactions EXP Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of MIR99B mRNA] CTD PMID:30290168 NCBI chr 1:59,704,216...59,704,285
Ensembl chr 1:59,704,216...59,704,285
JBrowse link
G Mme membrane metallo-endopeptidase decreases expression EXP Metformin results in decreased expression of MME mRNA CTD PMID:31324951 NCBI chr 2:153,799,203...153,880,910
Ensembl chr 2:153,803,349...153,880,738
JBrowse link
G Mmp10 matrix metallopeptidase 10 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA] CTD PMID:26497364 NCBI chr 8:5,734,348...5,742,243
Ensembl chr 8:5,734,348...5,742,243
JBrowse link
G Mmp14 matrix metallopeptidase 14 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA] CTD PMID:26497364 NCBI chr15:33,074,441...33,083,666
Ensembl chr15:33,074,441...33,083,655
JBrowse link
G Mmp19 matrix metallopeptidase 19 increases expression EXP Metformin results in increased expression of MMP19 mRNA CTD PMID:25596134 NCBI chr 7:3,216,392...3,224,202
Ensembl chr 7:3,216,497...3,224,201
JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions
decreases expression
decreases activity
ISO Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein]
Metformin results in decreased expression of MMP2 mRNA
Metformin results in decreased activity of MMP2 protein
CTD PMID:20590612, PMID:22246099 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
decreases expression
decreases activity
ISO Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]
Metformin inhibits the reaction [IL13 protein results in increased expression of MMP9 mRNA]
Metformin results in decreased expression of MMP9 mRNA
Metformin results in decreased activity of MMP9 protein
CTD PMID:20590612, PMID:22246099, PMID:26497364 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Mocos molybdenum cofactor sulfurase decreases expression EXP Metformin results in decreased expression of MOCOS mRNA CTD PMID:31324951 NCBI chr18:16,590,086...16,636,312
Ensembl chr18:16,590,197...16,636,084
JBrowse link
G Mpo myeloperoxidase multiple interactions ISO Metformin inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein] CTD PMID:24717679 NCBI chr10:75,087,892...75,098,260
Ensembl chr10:75,087,892...75,098,260
JBrowse link
G Mrc1 mannose receptor, C type 1 multiple interactions ISO Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 protein] CTD PMID:26497364 NCBI chr17:81,352,700...81,433,743
Ensembl chr17:81,352,700...81,433,743
JBrowse link
G Msc musculin decreases expression EXP Metformin results in decreased expression of MSC mRNA CTD PMID:25596134 NCBI chr 5:3,954,902...3,956,974
Ensembl chr 5:3,955,227...3,956,572
JBrowse link
G Msmo1 methylsterol monooxygenase 1 increases expression EXP Metformin results in increased expression of MSMO1 mRNA CTD PMID:31324951 NCBI chr16:26,859,441...26,875,880
Ensembl chr16:26,859,397...26,875,973
JBrowse link
G Mt-co1 mitochondrially encoded cytochrome c oxidase I increases expression ISO Metformin results in increased expression of COX1 protein CTD PMID:23166782 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
JBrowse link
G Mt1 metallothionein 1 affects expression EXP Metformin affects the expression of MT1A mRNA; Metformin affects the expression of MT1M mRNA CTD PMID:31324951 NCBI chr19:11,301,991...11,303,007
Ensembl chr17:78,793,336...78,793,724
JBrowse link
G Mt1m metallothionein 1M affects expression EXP Metformin affects the expression of MT1F mRNA CTD PMID:31324951 NCBI chr20:3,677,460...3,677,838
Ensembl chr20:3,677,474...3,677,847
JBrowse link
G Mt2A metallothionein 2A affects expression EXP Metformin affects the expression of MT2A mRNA CTD PMID:31324951 NCBI chr19:11,307,966...11,308,740
Ensembl chr19:11,307,967...11,308,740
JBrowse link
G Mtdh metadherin increases expression EXP Metformin results in increased expression of MTDH mRNA CTD PMID:25596134 NCBI chr 7:72,771,018...72,830,599
Ensembl chr 7:72,772,440...72,827,908
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
ISO
EXP
[Metformin co-treated with Pioglitazone] results in decreased expression of MTOR mRNA; Metformin results in decreased phosphorylation of and results in increased expression of MTOR protein
Metformin results in decreased phosphorylation of MTOR protein
CTD PMID:23363784, PMID:27363783, PMID:32589349 NCBI chr 5:165,263,813...165,373,967
Ensembl chr 5:165,263,800...165,373,967
JBrowse link
G Mug2 murinoglobulin 2 decreases expression ISO Metformin results in decreased expression of MUG2 mRNA CTD PMID:23457588 NCBI chr 4:154,215,262...154,282,608
Ensembl chr 4:154,215,250...154,282,608
JBrowse link
G Mvd mevalonate diphosphate decarboxylase increases expression EXP Metformin results in increased expression of MVD mRNA CTD PMID:31324951 NCBI chr19:55,258,910...55,268,933
Ensembl chr19:55,258,905...55,268,951
JBrowse link
G Mx1 myxovirus (influenza virus) resistance 1 increases expression EXP Metformin results in increased expression of MX2 mRNA CTD PMID:31324951 NCBI chr11:37,891,150...37,916,775
Ensembl chr11:37,891,156...37,914,983
JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor increases expression
multiple interactions
decreases expression
ISO
EXP
Metformin results in increased expression of MYC mRNA
[Paclitaxel co-treated with Metformin] results in decreased expression of MYC mRNA
Metformin results in decreased expression of MYC mRNA
CTD PMID:19022234, PMID:29309887 NCBI chr 7:102,586,313...102,591,240
Ensembl chr 7:102,586,313...102,591,240
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions EXP Metformin inhibits the reaction [Isoproterenol results in increased expression of MYD88 mRNA] CTD PMID:24842192 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
JBrowse link
G Myh6 myosin heavy chain 6 multiple interactions EXP Metformin inhibits the reaction [Doxorubicin results in decreased expression of MYH6 mRNA] CTD PMID:22666520 NCBI chr15:33,605,653...33,629,730
Ensembl chr15:33,605,654...33,629,699
JBrowse link
G Myh7 myosin heavy chain 7 multiple interactions EXP Metformin inhibits the reaction [Doxorubicin results in increased expression of MYH7 mRNA] CTD PMID:22666520 NCBI chr15:33,605,769...33,657,761
Ensembl chr15:33,634,422...33,656,089
JBrowse link
G Myzap myocardial zonula adherens protein multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MYZAP mRNA] CTD PMID:29095437 NCBI chr 8:78,009,019...78,096,409
Ensembl chr 8:77,985,190...78,096,390
JBrowse link
G Naglu N-acetyl-alpha-glucosaminidase multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of NAGLU mRNA] CTD PMID:29095437 NCBI chr10:88,979,363...88,986,879
Ensembl chr10:88,979,383...88,986,867
JBrowse link
G Nampt nicotinamide phosphoribosyltransferase affects expression
multiple interactions
increases expression
ISO
EXP
Metformin affects the expression of NAMPT mRNA; Metformin affects the expression of NAMPT protein
Metformin inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA]
Metformin results in increased expression of NAMPT mRNA
SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA]
CTD PMID:23315983, PMID:25596134, PMID:32298659 NCBI chr 6:52,122,085...52,156,473
Ensembl chr 6:52,122,085...52,156,472
JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression
increases expression
EXP Metformin results in decreased expression of NARS1 mRNA
Metformin results in increased expression of NARS mRNA
CTD PMID:25596134, PMID:31324951 NCBI chr18:59,986,350...60,002,644
Ensembl chr18:59,986,360...60,002,569
JBrowse link
G Ncapd2 non-SMC condensin I complex, subunit D2 increases expression EXP Metformin results in increased expression of NCAPD2 mRNA CTD PMID:25596134 NCBI chr 4:157,682,855...157,705,903
Ensembl chr 4:157,683,077...157,704,596
JBrowse link
G Ncf1 neutrophil cytosolic factor 1 decreases expression EXP Metformin results in decreased expression of NCF1 mRNA CTD PMID:31324951 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
JBrowse link
G Nedd9 neural precursor cell expressed, developmentally down-regulated 9 decreases expression EXP Metformin results in decreased expression of NEDD9 mRNA CTD PMID:25596134 NCBI chr17:22,984,792...23,179,701
Ensembl chr17:22,984,844...23,179,701
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 decreases expression
increases activity
affects activity
multiple interactions
ISO
EXP
Metformin results in decreased expression of NFE2L2 mRNA; Metformin results in decreased expression of NFE2L2 protein
Metformin results in increased activity of NFE2L2 protein
Metformin affects the activity of NFE2L2 protein
Metformin inhibits the reaction [2-tert-butylhydroquinone results in increased stability of and affects the localization of NFE2L2 protein]
CTD PMID:22627169, PMID:23707609, PMID:25596134, PMID:30114225 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions ISO
EXP
[Paclitaxel co-treated with Metformin] results in decreased expression of NFKB1 mRNA
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of NFKB1 mRNA]
CTD PMID:29309887, PMID:31100278 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of NFKB2 mRNA CTD PMID:29309887 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
decreases expression
ISO
EXP
Metformin results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein
Metformin results in decreased expression of NFKBIA mRNA
CTD PMID:21054339, PMID:31324951 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nin ninein increases expression EXP Metformin results in increased expression of NIN mRNA CTD PMID:25596134 NCBI chr 6:92,423,412...92,527,776
Ensembl chr 6:92,433,381...92,527,711
JBrowse link
G Ninj1 ninjurin 1 increases expression EXP Metformin results in increased expression of NINJ1 mRNA CTD PMID:25596134 NCBI chr17:15,866,235...15,881,284
Ensembl chr17:15,866,237...15,881,327
JBrowse link
G Nmur1 neuromedin U receptor 1 decreases expression EXP Metformin results in decreased expression of NMUR1 mRNA CTD PMID:25596134 NCBI chr 9:93,402,871...93,407,264
Ensembl chr 9:93,403,314...93,404,883
JBrowse link
G Noct nocturnin affects expression EXP Metformin affects the expression of NOCT mRNA CTD PMID:31324951 NCBI chr 2:140,286,661...140,306,869
Ensembl chr 2:140,286,661...140,306,869
JBrowse link
G Nod1 nucleotide-binding oligomerization domain containing 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of NOD1 mRNA CTD PMID:29309887 NCBI chr 4:85,123,965...85,175,206
Ensembl chr 4:85,123,960...85,174,951
JBrowse link
G Nop58 NOP58 ribonucleoprotein increases expression EXP Metformin results in increased expression of NOP58 mRNA CTD PMID:31324951 NCBI chr 9:66,495,881...66,520,521
Ensembl chr 9:66,495,832...66,519,788
JBrowse link
G Nos1 nitric oxide synthase 1 affects response to substance ISO NOS1 protein affects the susceptibility to Metformin CTD PMID:20847317 NCBI chr12:44,214,949...44,405,530
Ensembl chr12:44,213,943...44,520,341
JBrowse link
G Nos2 nitric oxide synthase 2 increases response to substance
multiple interactions
increases expression
ISO
EXP
NOS2 protein results in increased susceptibility to Metformin
Metformin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]
Metformin results in increased expression of NOS2 protein
CTD PMID:24770553, PMID:25108154 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP
ISO
Metformin inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]; Metformin inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]]
[Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]
CTD PMID:25108154, PMID:25601987 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
JBrowse link
G Nphs1 NPHS1 adhesion molecule, nephrin multiple interactions EXP Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA] CTD PMID:30551545 NCBI chr 1:88,922,346...88,950,560
Ensembl chr 1:88,922,433...88,950,559
JBrowse link
G Nppa natriuretic peptide A multiple interactions EXP Metformin inhibits the reaction [Glucose results in increased expression of NPPA protein] CTD PMID:30144576 NCBI chr 5:164,808,407...164,809,716
Ensembl chr 5:164,808,323...164,809,705
JBrowse link
G Npy neuropeptide Y multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of NPY mRNA] CTD PMID:32652086 NCBI chr 4:79,557,856...79,565,059
Ensembl chr 4:79,557,854...79,565,097
JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions
increases expression
decreases expression
EXP
ISO
Metformin inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NQO1 mRNA]
Metformin results in increased expression of NQO1 mRNA
Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of and results in increased activity of NQO1 protein]; Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NQO1 mRNA]
Metformin results in decreased expression of NQO1 protein
Metformin results in decreased expression of NQO1 mRNA
CTD PMID:21457706, PMID:22666520, PMID:23707609, PMID:25596134, PMID:25697376 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO Metformin results in decreased expression of NR0B2 mRNA CTD PMID:24428821 NCBI chr 5:151,776,004...151,779,319
Ensembl chr 5:151,776,004...151,779,319
JBrowse link
G Nr1d1 nuclear receptor subfamily 1, group D, member 1 increases expression EXP Metformin results in increased expression of NR1D1 mRNA CTD PMID:31324951 NCBI chr10:86,683,875...86,690,815
Ensembl chr10:86,683,875...86,690,815
JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 decreases expression
multiple interactions
EXP
ISO
Metformin results in decreased expression of NR1I2 mRNA
NR1I2 protein affects the susceptibility to [Pregnenolone Carbonitrile co-treated with Metformin]
CTD PMID:19022234, PMID:21920351 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
JBrowse link
G Nr1i3 nuclear receptor subfamily 1, group I, member 3 multiple interactions EXP Metformin promotes the reaction [Phenobarbital results in increased activity of NR1I3 protein] CTD PMID:20686344 NCBI chr13:89,585,072...89,591,278
Ensembl chr13:89,586,283...89,591,277
JBrowse link
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 decreases expression ISO Metformin results in decreased expression of NR3C1 mRNA; Metformin results in decreased expression of NR3C1 protein CTD PMID:25110054 NCBI chr18:31,728,373...32,704,022
Ensembl chr18:31,728,373...31,749,647
JBrowse link
G Nr4a1 nuclear receptor subfamily 4, group A, member 1 decreases expression EXP Metformin results in decreased expression of NR4A1 mRNA CTD PMID:31324951 NCBI chr 7:142,899,358...142,920,216
Ensembl chr 7:142,905,758...142,920,216
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 decreases expression EXP Metformin results in decreased expression of NR4A2 mRNA CTD PMID:31324951 NCBI chr 3:43,111,258...43,128,391
Ensembl chr 3:43,111,240...43,119,159
JBrowse link
G Nr4a3 nuclear receptor subfamily 4, group A, member 3 decreases expression EXP Metformin results in decreased expression of NR4A3 mRNA CTD PMID:31324951 NCBI chr 5:63,781,801...63,822,890
Ensembl chr 5:63,781,801...63,821,637
JBrowse link
G Nras NRAS proto-oncogene, GTPase multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of NRAS mRNA CTD PMID:29309887 NCBI chr 2:205,553,119...205,563,716
Ensembl chr 2:205,553,163...205,560,791
JBrowse link
G Nrf1 nuclear respiratory factor 1 increases expression ISO Metformin results in increased expression of NRF1 mRNA CTD PMID:16380484, PMID:24428821 NCBI chr 4:57,335,732...57,445,317
Ensembl chr 4:57,378,069...57,445,341
JBrowse link
G Ntpcr nucleoside-triphosphatase, cancer-related decreases expression EXP Metformin results in decreased expression of NTPCR mRNA CTD PMID:25596134 NCBI chr19:58,565,576...58,579,276
Ensembl chr19:58,565,576...58,579,265
JBrowse link
G Nupr1 nuclear protein 1, transcriptional regulator increases expression EXP Metformin results in increased expression of NUPR1 mRNA CTD PMID:31324951 NCBI chr 1:194,767,484...194,769,519
Ensembl chr 1:194,767,474...194,769,524
JBrowse link
G Oat ornithine aminotransferase decreases expression EXP Metformin results in decreased expression of OAT mRNA CTD PMID:31324951 NCBI chr 1:204,562,289...204,582,070
Ensembl chr 1:204,562,289...204,582,070
JBrowse link
G Oga O-GlcNAcase multiple interactions EXP Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein] CTD PMID:30551545 NCBI chr 1:265,506,752...265,542,452
Ensembl chr 1:265,507,451...265,542,276
JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of OGG1 mRNA] CTD PMID:25697376 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326
JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions EXP Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA] CTD PMID:27634381 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
JBrowse link
G Olr906 olfactory receptor 906 decreases expression EXP Metformin results in decreased expression of OLR906 mRNA CTD PMID:31324951 NCBI chr 4:13,610,125...13,611,059
Ensembl chr 7:5,450,324...5,451,262
JBrowse link
G Onecut1 one cut homeobox 1 decreases expression EXP Metformin results in decreased expression of ONECUT1 mRNA CTD PMID:31324951 NCBI chr 8:81,765,779...81,799,894
Ensembl chr 8:81,766,041...81,793,577
JBrowse link
G Opa1 OPA1, mitochondrial dynamin like GTPase multiple interactions EXP Metformin inhibits the reaction [Glucose results in decreased expression of OPA1 protein] CTD PMID:30144576 NCBI chr11:74,717,600...74,793,902
Ensembl chr11:74,720,254...74,793,803
JBrowse link
G Orai3 ORAI calcium release-activated calcium modulator 3 decreases expression EXP Metformin results in decreased expression of ORAI3 mRNA CTD PMID:25596134 NCBI chr 1:199,217,504...199,222,363
Ensembl chr 1:199,217,016...199,222,851
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression
affects expression
EXP Metformin results in decreased expression of OSGIN1 mRNA
Metformin affects the expression of OSGIN1 mRNA
CTD PMID:25596134, PMID:31324951 NCBI chr19:52,056,808...52,085,491
Ensembl chr19:52,077,109...52,085,496
JBrowse link
G Otub2 OTU deubiquitinase, ubiquitin aldehyde binding 2 increases expression EXP Metformin results in increased expression of OTUB2 mRNA CTD PMID:31324951 NCBI chr 6:127,282,445...127,301,086
Ensembl chr 6:127,282,466...127,301,083
JBrowse link
G Otud1 OTU deubiquitinase 1 decreases expression EXP Metformin results in decreased expression of OTUD1 mRNA CTD PMID:31324951 NCBI chr17:86,406,643...86,410,670
Ensembl chr17:86,408,151...86,409,518
JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression EXP Metformin results in increased expression of P2RX7 mRNA CTD PMID:31324951 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
JBrowse link
G Pank1 pantothenate kinase 1 decreases expression EXP Metformin results in decreased expression of PANK1 mRNA CTD PMID:25596134 NCBI chr 1:253,115,400...253,189,643
Ensembl chr 1:253,119,112...253,185,533
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases expression
EXP
ISO
Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of PARP1 protein]
Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]
Metformin results in increased expression of PARP1 mRNA
[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA; Sodium Salicylate promotes the reaction [Metformin results in increased expression of PARP1 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA]
CTD PMID:27551045, PMID:29095437, PMID:29117515 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 multiple interactions
decreases expression
ISO
EXP
Metformin inhibits the reaction [Bucladesine results in increased expression of PCK1 mRNA]; Metformin inhibits the reaction [PPARGC1A protein results in increased expression of PCK1 mRNA]
Metformin results in decreased expression of PCK1 mRNA
CTD PMID:22117073, PMID:24428821, PMID:31324951 NCBI chr 3:171,213,936...171,219,885
Ensembl chr 3:171,213,936...171,219,871
JBrowse link
G Pde8a phosphodiesterase 8A decreases expression EXP Metformin results in decreased expression of PDE8A mRNA CTD PMID:25596134 NCBI chr 1:143,036,083...143,160,395
Ensembl chr 1:143,036,218...143,159,433
JBrowse link
G Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 multiple interactions ISO Metformin results in decreased phosphorylation of and results in increased activity of PDHA1 protein CTD PMID:28576465 NCBI chr  X:37,329,779...37,343,410
Ensembl chr  X:37,329,779...37,343,410
JBrowse link
G Pdia5 protein disulfide isomerase family A, member 5 decreases expression EXP Metformin results in decreased expression of PDIA5 mRNA CTD PMID:25596134 NCBI chr11:68,493,035...68,578,999
Ensembl chr11:68,493,035...68,578,995
JBrowse link
G Pdk1 pyruvate dehydrogenase kinase 1 affects expression
increases expression
EXP Metformin affects the expression of PDK1 mRNA
Metformin results in increased expression of PDK1 mRNA
CTD PMID:25596134, PMID:31324951 NCBI chr 3:58,530,870...58,561,494
Ensembl chr 3:58,530,870...58,558,027
JBrowse link
G Pdk4 pyruvate dehydrogenase kinase 4 decreases expression EXP Metformin results in decreased expression of PDK4 mRNA CTD PMID:25596134 NCBI chr 4:30,546,772...30,556,774
Ensembl chr 4:30,546,664...30,556,814
JBrowse link
G Pdlim1 PDZ and LIM domain 1 increases expression EXP Metformin results in increased expression of PDLIM1 mRNA CTD PMID:25596134 NCBI chr 1:259,308,326...259,357,006
Ensembl chr 1:259,308,296...259,357,056
JBrowse link
G Pdlim3 PDZ and LIM domain 3 decreases expression EXP Metformin results in decreased expression of PDLIM3 mRNA CTD PMID:31324951 NCBI chr16:49,543,140...49,574,362
Ensembl chr16:49,543,142...49,574,390
JBrowse link
G Pdpk1 3-phosphoinositide dependent protein kinase-1 decreases expression ISO Metformin results in decreased expression of PDPK1 mRNA CTD PMID:32589349 NCBI chr10:13,446,373...13,525,248
Ensembl chr10:13,451,624...13,515,448
JBrowse link
G Pdrg1 p53 and DNA damage regulated 1 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PDRG1 mRNA] CTD PMID:29095437 NCBI chr 3:148,487,056...148,493,225
Ensembl chr 3:148,487,059...148,493,225
JBrowse link
G Pdx1 pancreatic and duodenal homeobox 1 multiple interactions
increases expression
ISO [Metformin co-treated with Glucose] affects the localization of PDX1 protein
Metformin results in increased expression of PDX1 protein
CTD PMID:16489446 NCBI chr12:9,496,044...9,501,211
Ensembl chr12:9,496,044...9,501,213
JBrowse link
G Penk proenkephalin increases expression EXP Metformin results in increased expression of PENK mRNA CTD PMID:31324951 NCBI chr 5:17,056,412...17,061,762
Ensembl chr 5:17,056,419...17,061,837
JBrowse link
G Per1 period circadian regulator 1 decreases expression EXP Metformin results in decreased expression of PER1 mRNA CTD PMID:31324951 NCBI chr10:55,681,761...55,696,557
Ensembl chr10:55,687,050...55,695,994
JBrowse link
G Pfkfb1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 increases expression EXP Metformin results in increased expression of PFKFB1 mRNA CTD PMID:31324951 NCBI chr  X:23,092,143...23,145,923
Ensembl chr  X:23,092,159...23,144,324
JBrowse link
G Pgm2 phosphoglucomutase 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PGM2 mRNA] CTD PMID:29095437 NCBI chr14:45,829,440...45,863,883
Ensembl chr14:45,829,446...45,863,877
JBrowse link
G Phgdh phosphoglycerate dehydrogenase increases expression EXP Metformin results in increased expression of PHGDH mRNA CTD PMID:25596134 NCBI chr 2:200,484,245...200,513,564
Ensembl chr 2:200,484,246...200,513,564
JBrowse link
G Phkg1 phosphorylase kinase catalytic subunit gamma 1 decreases expression EXP Metformin results in decreased expression of PHKG1 mRNA CTD PMID:31324951 NCBI chr12:30,450,431...30,464,314
Ensembl chr12:30,450,316...30,464,352
JBrowse link
G Phlda3 pleckstrin homology-like domain, family A, member 3 increases expression
multiple interactions
EXP
ISO
Metformin results in increased expression of PHLDA3 mRNA
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PHLDA3 mRNA]
CTD PMID:25596134, PMID:29095437 NCBI chr13:52,588,917...52,592,002
Ensembl chr13:52,588,917...52,592,001
JBrowse link
G Pias2 protein inhibitor of activated STAT, 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PIAS2 mRNA] CTD PMID:29095437 NCBI chr18:73,479,863...73,524,956
Ensembl chr18:73,378,662...73,524,956
JBrowse link
G Pidd1 p53-induced death domain protein 1 increases expression EXP Metformin results in increased expression of PIDD1 mRNA CTD PMID:25596134 NCBI chr 1:214,418,751...214,423,959
Ensembl chr 1:214,419,240...214,423,881
JBrowse link
G Pik3c3 phosphatidylinositol 3-kinase, catalytic subunit type 3 decreases expression
multiple interactions
ISO Metformin results in decreased expression of PIK3C3 mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3C3 mRNA
CTD PMID:32589349 NCBI chr18:22,964,121...23,047,896
Ensembl chr18:22,964,210...23,047,895
JBrowse link
G Pik3ca phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha multiple interactions
decreases expression
ISO [Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CA mRNA
Metformin results in decreased expression of PIK3CA mRNA
CTD PMID:32589349 NCBI chr 2:118,831,350...118,861,456
Ensembl chr 2:118,831,350...118,861,454
JBrowse link
G Pik3cb phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta multiple interactions ISO [Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CB mRNA CTD PMID:32589349 NCBI chr 8:107,275,849...107,381,088
Ensembl chr 8:107,275,725...107,380,933
JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma decreases expression
multiple interactions
ISO Metformin results in decreased expression of PIK3CG mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CG mRNA
CTD PMID:32589349 NCBI chr 6:51,465,696...51,501,234
Ensembl chr 6:51,465,908...51,498,337
JBrowse link
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 increases expression
multiple interactions
decreases expression
ISO
EXP
Metformin results in increased expression of PIK3R1 mRNA
Metformin inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA]
Metformin results in decreased expression of PIK3R1 mRNA
CTD PMID:21870829, PMID:31324951, PMID:32652086 NCBI chr 2:31,742,326...31,826,882
Ensembl chr 2:31,745,088...31,826,867
JBrowse link
G Pilra paired immunoglobin-like type 2 receptor alpha multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PILRA mRNA] CTD PMID:29095437 NCBI chr12:21,412,598...21,418,621
Ensembl chr12:21,412,538...21,420,169
JBrowse link
G Pir pirin decreases expression EXP Metformin results in decreased expression of PIR mRNA CTD PMID:25596134 NCBI chr  X:31,852,322...31,968,152
Ensembl chr  X:31,852,323...31,968,152
JBrowse link
G Pklr pyruvate kinase L/R increases expression EXP Metformin results in increased expression of PKLR mRNA CTD PMID:31324951 NCBI chr 2:188,449,158...188,458,034
Ensembl chr 2:188,449,210...188,459,592
JBrowse link
G Pla2g12a phospholipase A2, group XIIA affects expression EXP Metformin affects the expression of PLA2G12A mRNA CTD PMID:31324951 NCBI chr 2:235,311,664...235,327,972
Ensembl chr 2:235,311,719...235,327,972
JBrowse link
G Plat plasminogen activator, tissue type increases activity ISO Metformin results in increased activity of PLAT protein CTD PMID:1900072 NCBI chr16:74,098,263...74,122,897
Ensembl chr16:74,098,260...74,122,889
JBrowse link
G Pld1 phospholipase D1 decreases expression
multiple interactions
ISO Metformin results in decreased expression of PLD1 mRNA
[Metformin co-treated with Pioglitazone] results in decreased expression of PLD1 mRNA
CTD PMID:32589349 NCBI chr 2:113,651,967...113,849,403
Ensembl chr 2:113,652,348...113,849,403
JBrowse link
G Plekhb1 pleckstrin homology domain containing B1 increases expression EXP Metformin results in increased expression of PLEKHB1 mRNA CTD PMID:31324951 NCBI chr 1:165,665,905...165,683,753
Ensembl chr 1:165,665,909...165,680,206
JBrowse link
G Plin2 perilipin 2 affects expression EXP Metformin affects the expression of PLIN2 mRNA CTD PMID:25596134 NCBI chr 5:104,984,413...105,010,863
Ensembl chr 5:104,984,414...105,010,857
JBrowse link
G Plk2 polo-like kinase 2 increases expression EXP Metformin results in increased expression of PLK2 mRNA CTD PMID:31324951 NCBI chr 2:41,911,143...41,916,901
Ensembl chr 2:41,911,131...41,916,901
JBrowse link
G Plppr1 phospholipid phosphatase related 1 increases expression EXP Metformin results in increased expression of PLPPR1 mRNA CTD PMID:31324951 NCBI chr 5:67,852,817...67,985,310
Ensembl chr 5:67,852,180...68,139,199
JBrowse link
G Pltp phospholipid transfer protein decreases expression EXP Metformin results in decreased expression of PLTP mRNA CTD PMID:31324951 NCBI chr 3:161,304,469...161,322,289
Ensembl chr 3:161,304,469...161,322,289
JBrowse link
G Pmepa1 prostate transmembrane protein, androgen induced 1 affects expression EXP Metformin affects the expression of PMEPA1 mRNA CTD PMID:25596134 NCBI chr 3:171,295,630...171,342,662
Ensembl chr 3:171,294,856...171,342,646
JBrowse link
G Pmm2 phosphomannomutase 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PMM2 mRNA] CTD PMID:29095437 NCBI chr10:7,056,258...7,077,443
Ensembl chr10:7,056,266...7,077,443
JBrowse link
G Pnpla3 patatin-like phospholipase domain containing 3 affects expression EXP Metformin affects the expression of PNPLA3 mRNA CTD PMID:31324951 NCBI chr 7:125,034,760...125,056,165
Ensembl chr 7:125,034,764...125,055,976
JBrowse link
G Pnpla6 patatin-like phospholipase domain containing 6 decreases expression EXP Metformin results in decreased expression of PNPLA6 mRNA CTD PMID:25596134 NCBI chr12:2,068,749...2,098,139
Ensembl chr12:2,069,959...2,097,904
JBrowse link
G Podxl podocalyxin-like increases expression EXP Metformin results in increased expression of PODXL mRNA CTD PMID:25596134 NCBI chr 4:58,829,049...58,893,353
Ensembl chr 4:58,829,060...58,893,170
JBrowse link
G Polr3f RNA polymerase III subunit F increases expression EXP Metformin results in increased expression of POLR3F mRNA CTD PMID:25596134 NCBI chr 3:138,684,685...138,701,055
Ensembl chr 3:138,684,685...138,701,055
JBrowse link
G Pomc proopiomelanocortin multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] CTD PMID:32652086 NCBI chr 6:28,382,937...28,388,771
Ensembl chr 6:28,382,962...28,388,967
JBrowse link
G Pon1 paraoxonase 1 increases response to substance ISO PON1 gene mutant form results in increased susceptibility to Metformin CTD PMID:26945512 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions ISO Metformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]] CTD PMID:22132214 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
JBrowse link
G Ppan peter pan homolog increases expression EXP Metformin results in increased expression of PPAN mRNA CTD PMID:25596134 NCBI chr 8:21,905,865...21,909,845
Ensembl chr 8:21,905,865...21,909,842
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions
increases expression
increases activity
decreases expression
ISO
EXP
[rosiglitazone co-treated with Metformin] results in increased expression of PPARA mRNA; [rosiglitazone co-treated with Metformin] results in increased expression of PPARA protein; Metformin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA]
Metformin results in increased expression of PPARA mRNA
Metformin results in increased activity of PPARA protein
Metformin results in decreased expression of PPARA mRNA
CTD PMID:20823565, PMID:22117073, PMID:23166782, PMID:23927877, PMID:29991592, PMID:31324951 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma decreases expression
multiple interactions
affects activity
increases expression
ISO
EXP
Metformin results in decreased expression of PPARG mRNA
Metformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA]
Metformin affects the activity of PPARG protein
Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA]
Metformin results in increased expression of PPARG mRNA
CTD PMID:20724125, PMID:20956498, PMID:21870829, PMID:25108154, PMID:25596134, PMID:26497364, PMID:30256492 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
JBrowse link
G Ppargc1a PPARG coactivator 1 alpha multiple interactions
increases expression
ISO PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]
Metformin results in increased expression of PPARGC1A mRNA; Metformin results in increased expression of PPARGC1A protein
dorsomorphin inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [Bucladesine results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; Metformin inhibits the reaction [PPARGC1A protein results in decreased expression of TNFSF12 mRNA]; Metformin inhibits the reaction [PPARGC1A protein results in increased expression of PCK1 mRNA]; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; PRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; SIRT1 mutant form inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]
CTD PMID:15864539, PMID:16380484, PMID:22117073, PMID:23090186, PMID:24428821 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
JBrowse link
G Ppfibp1 PPFIA binding protein 1 increases expression EXP Metformin results in increased expression of PPFIBP1 mRNA CTD PMID:25596134 NCBI chr 4:181,285,179...181,428,157
Ensembl chr 4:181,286,455...181,428,157
JBrowse link
G Ppm1d protein phosphatase, Mg2+/Mn2+ dependent, 1D multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PPM1D mRNA] CTD PMID:29095437 NCBI chr10:72,909,550...72,945,884
Ensembl chr10:72,909,550...72,945,884
JBrowse link
G Ppm1k protein phosphatase, Mg2+/Mn2+ dependent, 1K decreases expression EXP Metformin results in decreased expression of PPM1K mRNA CTD PMID:31324951 NCBI chr 4:88,694,395...88,721,374
Ensembl chr 4:88,694,583...88,718,533
JBrowse link
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A increases expression EXP
ISO
Metformin results in increased expression of PPP1R15A mRNA CTD PMID:25596134 NCBI chr 1:101,511,899...101,515,043
Ensembl chr 1:101,511,901...101,514,974
JBrowse link
G Ppp1r3c protein phosphatase 1, regulatory subunit 3C increases expression EXP Metformin results in increased expression of PPP1R3C mRNA CTD PMID:31324951 NCBI chr 1:255,371,830...255,376,833
Ensembl chr 1:255,371,810...255,376,833
JBrowse link
G Ppp4r2 protein phosphatase 4, regulatory subunit 2 decreases expression EXP Metformin results in decreased expression of PPP4R2 mRNA CTD PMID:25596134 NCBI chr 4:133,285,552...133,323,755
Ensembl chr 4:133,285,552...133,323,755
JBrowse link
G Prc1 protein regulator of cytokinesis 1 increases expression EXP Metformin results in increased expression of PRC1 mRNA CTD PMID:25596134 NCBI chr 1:142,087,181...142,108,746
Ensembl chr 1:142,087,208...142,108,746
JBrowse link
G Prdm1 PR/SET domain 1 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in increased expression of PRDM1 mRNA CTD PMID:29309887 NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
JBrowse link
G Prdx2 peroxiredoxin 2 decreases expression ISO Metformin results in decreased expression of PRDX2 mRNA CTD PMID:23457588 NCBI chr19:26,084,816...26,090,095
Ensembl chr19:26,084,903...26,090,094
JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions
increases phosphorylation
affects response to substance
ISO
EXP
Metformin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]; PRKAA1 protein affects the reaction [Metformin inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of ABCB1 protein]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of RELA protein]; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; PRKAA1 protein affects the reaction [Metformin results in increased expression of SOD2 mRNA]
PRKAA1 protein affects the susceptibility to Metformin
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSHB protein results in increased phosphorylation of PRKAA1 protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased expression of HSD3B protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased secretion of Progesterone]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]
Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]
CTD PMID:16380484, PMID:16760380, PMID:16873680, PMID:19052259, PMID:19594306, PMID:21054339, PMID:21186350, PMID:22815988, PMID:24428821, PMID:25601987, PMID:26497364 NCBI chr 2:54,857,688...54,893,404
Ensembl chr 2:54,857,688...54,893,404
JBrowse link
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 multiple interactions
increases phosphorylation
increases activity
affects response to substance
ISO
EXP
Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein
metformin inhibits the reaction [lipopolysaccharide decreases expression of Prkaa2 mRNA in left cardiac chamber] and decreases expression of Prkaa2 mRNA in left cardiac chamber
Metformin results in increased phosphorylation of PRKAA2 protein
Metformin results in increased activity of PRKAA2 protein
PRKAA2 protein affects the susceptibility to Metformin
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein
Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein; PRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]
CTD PMID:16873680, PMID:18484962, PMID:19052259, PMID:19594306, PMID:20847317, PMID:21186350, PMID:24428821, PMID:27621180 RGD:39456138 NCBI chr 5:124,568,845...124,642,569
Ensembl chr 5:124,574,079...124,642,569
JBrowse link
G Prkab2 protein kinase AMP-activated non-catalytic subunit beta 2 increases expression EXP Metformin results in increased expression of PRKAB2 mRNA CTD PMID:25596134 NCBI chr 2:199,831,990...199,847,623
Ensembl chr 2:199,831,990...199,847,629
JBrowse link
G Prkag2 protein kinase AMP-activated non-catalytic subunit gamma 2 multiple interactions ISO Metformin inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA] CTD PMID:32652086 NCBI chr 4:6,559,153...6,799,888
Ensembl chr 4:6,559,545...6,799,632
JBrowse link
G Prkca protein kinase C, alpha multiple interactions
decreases expression
ISO [Metformin co-treated with Pioglitazone] results in decreased expression of PRKCA mRNA; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein]
Metformin results in decreased expression of PRKCA mRNA
CTD PMID:20590612, PMID:32589349 NCBI chr10:96,186,509...96,585,168
Ensembl chr10:96,191,133...96,584,947
JBrowse link
G Prkcb protein kinase C, beta decreases expression ISO Metformin results in decreased expression of PRKCB mRNA; Metformin results in decreased expression of PRKCB protein CTD PMID:15531508 NCBI chr 1:192,233,569...192,575,339
Ensembl chr 1:192,233,910...192,574,831
JBrowse link
G Prl prolactin decreases secretion ISO Metformin results in decreased secretion of PRL protein CTD PMID:21664031 NCBI chr17:39,814,236...39,824,299
Ensembl chr17:39,814,244...39,824,299
JBrowse link
G Psat1 phosphoserine aminotransferase 1 increases expression EXP Metformin results in increased expression of PSAT1 mRNA CTD PMID:31324951 NCBI chr 1:233,124,089...233,145,941
Ensembl chr 1:233,124,092...233,145,941
JBrowse link
G Pten phosphatase and tensin homolog multiple interactions EXP Metformin inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA] CTD PMID:26492952 NCBI chr 1:251,421,814...251,487,634
Ensembl chr 1:251,421,596...251,487,832
JBrowse link
G Ptgfr prostaglandin F receptor decreases expression EXP Metformin results in decreased expression of PTGFR mRNA CTD PMID:31324951 NCBI chr 2:257,005,813...257,039,036
Ensembl chr 2:257,005,829...257,038,105
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP Metformin inhibits the reaction [Dietary Fats results in increased expression of PTGS2 protein] CTD PMID:27551045 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 multiple interactions ISO Metformin inhibits the reaction [INS protein results in increased expression of PTPN1 protein] CTD PMID:30928401 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
G Pxmp4 peroxisomal membrane protein 4 increases expression EXP Metformin results in increased expression of PXMP4 mRNA CTD PMID:31324951 NCBI chr 3:150,091,646...150,108,893
Ensembl chr 3:150,091,630...150,108,898
JBrowse link
G Pycr1 pyrroline-5-carboxylate reductase 1 increases expression EXP Metformin results in increased expression of PYCR1 mRNA CTD PMID:25596134 NCBI chr10:109,817,300...109,822,218
Ensembl chr10:109,818,177...109,821,807
JBrowse link
G Pygl glycogen phosphorylase L decreases expression EXP Metformin results in decreased expression of PYGL mRNA CTD PMID:25596134 NCBI chr 6:92,597,759...92,643,734
Ensembl chr 6:92,597,706...92,643,847
JBrowse link
G Rab33a RAB33A, member RAS oncogene family increases expression EXP Metformin results in increased expression of RAB33A mRNA CTD PMID:25596134 NCBI chr  X:135,348,799...135,360,204
Ensembl chr  X:135,348,436...135,360,203
JBrowse link
G Rab5a RAB5A, member RAS oncogene family multiple interactions EXP Metformin promotes the reaction [APPL1 protein binds to RAB5A protein] CTD PMID:29991592 NCBI chr 9:5,910...6,065 JBrowse link
G Rad51c RAD51 paralog C multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of RAD51C mRNA] CTD PMID:29095437 NCBI chr10:74,697,713...74,724,004
Ensembl chr10:74,697,716...74,724,472
JBrowse link
G Raf1 Raf-1 proto-oncogene, serine/threonine kinase decreases phosphorylation ISO Metformin results in decreased phosphorylation of RAF1 protein CTD PMID:23707609 NCBI chr 4:147,532,040...147,592,769
Ensembl chr 4:147,532,042...147,592,699
JBrowse link
G Rbp4 retinol binding protein 4 multiple interactions EXP Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] CTD PMID:19080170 NCBI chr 1:256,806,476...256,813,678
Ensembl chr 1:256,806,472...256,813,711
JBrowse link
G Rbp7 retinol binding protein 7 increases expression EXP Metformin results in increased expression of RBP7 mRNA CTD PMID:31324951 NCBI chr 5:166,278,214...166,282,832
Ensembl chr 5:166,278,187...166,282,831
JBrowse link
G Rd3l retinal degeneration 3-like decreases expression EXP Metformin results in decreased expression of RD3L mRNA CTD PMID:31324951 NCBI chr 6:136,548,412...136,550,316
Ensembl chr 6:136,548,307...136,550,371
JBrowse link
G Reg3g regenerating family member 3 gamma increases expression EXP Metformin results in increased expression of REG3G mRNA CTD PMID:31324951 NCBI chr 4:109,529,679...109,532,234
Ensembl chr 4:109,529,679...109,532,234
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases localization
multiple interactions
decreases phosphorylation
ISO
EXP
Metformin results in decreased localization of RELA protein
dorsomorphin inhibits the reaction [Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]; Metformin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein]; Metformin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]; Niacinamide inhibits the reaction [Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]
Metformin results in decreased phosphorylation of RELA protein
[Paclitaxel co-treated with Metformin] results in decreased expression of RELA mRNA; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [RELA protein results in increased expression of ABCB1 mRNA]; Metformin results in decreased expression of and affects the localization of RELA protein; PRKAA1 protein affects the reaction [Metformin results in decreased expression of RELA protein]
CTD PMID:16385087, PMID:21054339, PMID:25108154, PMID:27634381, PMID:29309887 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Retn resistin multiple interactions EXP Metformin inhibits the reaction [Fructose results in increased expression of RETN protein]; Metformin inhibits the reaction [Letrozole results in increased expression of RETN mRNA] CTD PMID:25108154, PMID:32298659 NCBI chr12:2,201,909...2,203,649
Ensembl chr12:2,201,891...2,204,249
JBrowse link
G Rffl ring finger and FYVE-like domain containing E3 ubiquitin protein ligase decreases expression EXP Metformin results in decreased expression of RFFL mRNA CTD PMID:25596134 NCBI chr10:70,157,621...70,220,618
Ensembl chr10:70,157,621...70,220,582
JBrowse link
G RGD1305184 similar to CDNA sequence BC023105 decreases expression EXP Metformin results in decreased expression of RGD1305184 mRNA CTD PMID:31324951 NCBI chr18:55,634,615...55,669,634
Ensembl chr18:55,666,027...55,667,668
JBrowse link
G RGD1309362 similar to interferon-inducible GTPase increases expression EXP Metformin results in increased expression of RGD1309362 mRNA CTD PMID:31324951 NCBI chr18:55,483,059...55,508,714
Ensembl chr18:55,505,993...55,508,704
JBrowse link
G RGD1559887 similar to Transducin-like enhancer protein 4 (Groucho-related protein 4) (Grg-4) decreases expression EXP Metformin results in decreased expression of RGD1559887 mRNA CTD PMID:31324951 NCBI chr 2:77,057,719...77,112,614 JBrowse link
G RGD1560801 similar to guanylate binding protein 1, interferon-inducible, 67kDa decreases expression EXP Metformin results in decreased expression of RGD1560801 mRNA CTD PMID:31324951 NCBI chr 2:248,533,339...248,561,766 JBrowse link
G RGD1560806 similar to Golgi phosphoprotein 3-like increases expression EXP Metformin results in increased expression of RGD1560806 mRNA CTD PMID:31324951 NCBI chr 9:50,422,475...50,423,825 JBrowse link
G RGD1563100 similar to KIAA0089 increases expression EXP Metformin results in increased expression of RGD1563100 mRNA CTD PMID:31324951 NCBI chr 7:100,699,866...100,701,886 JBrowse link
G RGD1563850 similar to Aldo-keto reductase family 1, member B8 decreases expression EXP Metformin results in decreased expression of RGD1563850 mRNA CTD PMID:31324951 NCBI chr 6:81,052,346...81,065,479 JBrowse link
G Rgs2 regulator of G-protein signaling 2 decreases expression EXP Metformin results in decreased expression of RGS2 mRNA CTD PMID:31324951 NCBI chr13:60,846,458...60,849,061
Ensembl chr13:60,846,308...60,849,094
JBrowse link
G Rhd Rh blood group, D antigen decreases expression EXP Metformin results in decreased expression of RHD mRNA CTD PMID:31324951 NCBI chr 5:153,197,416...153,232,009
Ensembl chr 5:153,197,459...153,232,687
JBrowse link
G Rhobtb1 Rho-related BTB domain containing 1 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of RHOBTB1 mRNA] CTD PMID:29095437 NCBI chr20:20,638,579...20,715,437
Ensembl chr20:20,638,579...20,713,128
JBrowse link
G Rictor RPTOR independent companion of MTOR, complex 2 multiple interactions
decreases expression
ISO [Metformin co-treated with Pioglitazone] results in decreased expression of RICTOR mRNA
Metformin results in decreased expression of RICTOR mRNA
CTD PMID:32589349 NCBI chr 2:56,013,898...56,105,818
Ensembl chr 2:56,052,643...56,101,803
JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO [Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; [Simvastatin co-treated with Metformin] results in increased expression of RIPK1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]] CTD PMID:25412314 NCBI chr17:31,537,580...31,569,904
Ensembl chr17:31,537,591...31,569,904
JBrowse link
G Ripk2 receptor-interacting serine-threonine kinase 2 multiple interactions ISO [Paclitaxel co-treated with Metformin] results in decreased expression of RIPK2 mRNA CTD PMID:29309887 NCBI chr 5:29,838,713...29,870,390
Ensembl chr 5:29,838,747...29,870,735
JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 multiple interactions ISO [Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]] CTD PMID:25412314 NCBI chr15:34,470,796...34,479,741
Ensembl chr15:34,470,796...34,479,741
JBrowse link
G Rlf RLF zinc finger increases expression EXP Metformin results in increased expression of RLF mRNA CTD PMID:25596134 NCBI chr 5:140,107,144...140,162,698
Ensembl chr 5:140,107,275...140,162,642
JBrowse link
G Rnasel ribonuclease L multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of RNASEL mRNA] CTD PMID:29095437 NCBI chr13:71,188,712...71,202,636
Ensembl chr13:71,192,142...71,202,625
JBrowse link
G Rnd1 Rho family GTPase 1 affects expression EXP Metformin affects the expression of RND1 mRNA CTD PMID:25596134 NCBI chr 7:140,349,138...140,356,209
Ensembl chr 7:140,349,138...140,356,209
JBrowse link
G Rnd3 Rho family GTPase 3 affects expression
increases expression
EXP Metformin affects the expression of RND3 mRNA
Metformin results in increased expression of RND3 mRNA
CTD PMID:25596134, PMID:31324951 NCBI chr 3:36,643,374...36,660,727
Ensembl chr 3:36,642,587...36,660,758
JBrowse link
G Rnf121 ring finger protein 121 increases expression EXP Metformin results in increased expression of RNF121 mRNA CTD PMID:25596134 NCBI chr 1:167,095,916...167,165,257
Ensembl chr 1:167,095,962...167,165,265
JBrowse link
G Ro60 Ro60, Y RNA binding protein affects expression EXP Metformin affects the expression of RO60 mRNA CTD PMID:25596134 NCBI chr13:60,546,892...60,567,882
Ensembl chr13:60,546,912...60,567,882
JBrowse link
G Rps6 ribosomal protein S6 decreases phosphorylation
multiple interactions
ISO
EXP
Metformin results in decreased phosphorylation of RPS6 protein
Trientine inhibits the reaction [Metformin results in decreased phosphorylation of RPS6 protein]
Metformin analog results in decreased phosphorylation of RPS6 protein; Metformin results in decreased phosphorylation of RPS6 protein
CTD PMID:22492524, PMID:23363784 NCBI chr 5:105,197,821...105,200,681
Ensembl chr 5:105,197,857...105,200,148
JBrowse link
G Rps6ka2 ribosomal protein S6 kinase A2 multiple interactions
increases expression
ISO [Metformin co-treated with Pioglitazone] results in increased expression of RPS6KA2 mRNA
Metformin results in increased expression of RPS6KA2 mRNA
CTD PMID:32589349 NCBI chr 1:53,219,346...53,499,445
Ensembl chr 1:53,360,157...53,499,445
JBrowse link
G Rps6ka5 ribosomal protein S6 kinase A5 multiple interactions
decreases expression
ISO [Metformin co-treated with Pioglitazone] results in decreased expression of RPS6KA5 mRNA
Metformin results in decreased expression of RPS6KA5 mRNA
CTD PMID:32589349 NCBI chr 6:124,557,892...124,735,787
Ensembl chr 6:124,557,913...124,735,778
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 multiple interactions ISO 3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]
[Paclitaxel co-treated with Metformin] results in decreased expression of RPS6KB1 mRNA
CTD PMID:29309887, PMID:29859833 NCBI chr10:73,824,200...73,865,503
Ensembl chr10:73,824,202...73,865,364
JBrowse link
G Rrm2 ribonucleotide reductase regulatory subunit M2 increases expression EXP Metformin results in increased expression of RRM2 mRNA CTD PMID:31324951 NCBI chr 6:43,884,627...43,890,818
Ensembl chr 6:43,884,678...43,889,515
JBrowse link
G Rrm2b ribonucleotide reductase regulatory TP53 inducible subunit M2B increases expression EXP Metformin results in increased expression of RRM2B mRNA CTD PMID:25596134 NCBI chr 7:76,750,045...76,780,817
Ensembl chr 7:76,750,050...76,780,817
JBrowse link
G Rsl1d1 ribosomal L1 domain containing 1 increases expression EXP Metformin results in increased expression of RSL1D1 mRNA CTD PMID:25596134 NCBI chr10:4,375,329...4,387,195
Ensembl chr10:4,356,915...4,390,030
JBrowse link
G Runx1 RUNX family transcription factor 1 increases expression EXP Metformin results in increased expression of RUNX1 mRNA CTD PMID:25596134 NCBI chr11:32,765,147...33,003,061
Ensembl chr11:32,769,165...33,003,021
JBrowse link
G Runx2 RUNX family transcription factor 2 increases expression EXP Metformin results in increased expression of RUNX2 protein CTD PMID:19594306 NCBI chr 9:18,564,743...18,773,092
Ensembl chr 9:18,564,927...18,773,092
JBrowse link
G Rxra retinoid X receptor alpha decreases expression EXP Metformin results in decreased expression of RXRA mRNA CTD PMID:25596134 NCBI chr 3:6,272,560...6,295,354
Ensembl chr 3:6,211,789...6,295,908
JBrowse link
G Sall1 spalt-like transcription factor 1 increases expression EXP Metformin results in increased expression of SALL1 mRNA CTD PMID:31324951 NCBI chr19:23,387,737...23,405,025
Ensembl chr19:23,389,375...23,405,039
JBrowse link
G Sars1 seryl-tRNA synthetase 1 increases expression EXP Metformin results in increased expression of SARS1 mRNA CTD PMID:25596134 NCBI chr 2:211,219,743...211,235,475
Ensembl chr 2:211,219,750...211,235,467
JBrowse link
G Sat1 spermidine/spermine N1-acetyl transferase 1 increases expression EXP Metformin results in increased expression of SAT1 mRNA CTD PMID:25596134 NCBI chr  X:43,626,480...43,629,767
Ensembl chr  X:43,625,169...43,629,765
JBrowse link
G Sbk1 SH3 domain binding kinase 1 increases expression EXP Metformin results in increased expression of SBK1 mRNA CTD PMID:31324951 NCBI chr 1:197,636,230...197,681,031
Ensembl chr 1:67,368,384...67,390,141
Ensembl chr 1:67,368,384...67,390,141
JBrowse link
G Scamp1 secretory carrier membrane protein 1 increases expression EXP Metformin results in increased expression of SCAMP1 mRNA CTD PMID:25596134 NCBI chr 2:23,858,021...23,941,128
Ensembl chr 2:23,857,995...23,941,084
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions
decreases expression
ISO
EXP
[Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein
Metformin results in decreased expression of SCD1 mRNA
CTD PMID:28576465, PMID:31324951 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Sdf2l1 stromal cell-derived factor 2-like 1 increases expression EXP Metformin results in increased expression of SDF2L1 mRNA CTD PMID:25596134 NCBI chr11:88,122,271...88,124,513
Ensembl chr11:88,122,271...88,124,513
JBrowse link
G Sds serine dehydratase decreases expression EXP Metformin results in decreased expression of SDS mRNA CTD PMID:31324951 NCBI chr12:41,620,429...41,627,741
Ensembl chr12:41,620,393...41,627,741
JBrowse link
G Sec23b Sec23 homolog B, COPII coat complex component increases expression EXP Metformin results in increased expression of SEC23B mRNA CTD PMID:31324951 NCBI chr 3:138,715,118...138,757,111
Ensembl chr 3:138,715,570...138,757,111
JBrowse link
G Selenop selenoprotein P multiple interactions EXP Metformin inhibits the reaction [Dexamethasone results in increased expression of SELENOP mRNA]; Metformin inhibits the reaction [Dexamethasone results in increased secretion of SELENOP protein]; Metformin inhibits the reaction [Glucose results in increased expression of SELENOP mRNA]; Metformin inhibits the reaction [Glucose results in increased secretion of SELENOP protein] CTD PMID:19576170 NCBI chr 2:53,105,912...53,116,198
Ensembl chr 2:53,109,684...53,114,858
JBrowse link
G Sephs2 selenophosphate synthetase 2 multiple interactions EXP Metformin inhibits the reaction [Dexamethasone results in increased expression of SEPHS2 mRNA] CTD PMID:19576170 NCBI chr 1:198,719,158...198,721,476
Ensembl chr 1:198,719,162...198,721,476
JBrowse link
G Serpinc1 serpin family C member 1 increases activity ISO Metformin results in increased activity of SERPINC1 protein CTD PMID:29458015 NCBI chr13:78,806,107...78,820,375
Ensembl chr13:78,805,347...78,833,192
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions EXP Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein] CTD PMID:25108154 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
JBrowse link
G Sertad1 SERTA domain containing 1 decreases expression EXP Metformin results in decreased expression of SERTAD1 mRNA CTD PMID:25596134 NCBI chr 1:84,293,102...84,296,370
Ensembl chr 1:84,293,102...84,296,367
JBrowse link
G Sesn1 sestrin 1 decreases expression EXP Metformin results in decreased expression of SESN1 mRNA CTD PMID:25596134 NCBI chr20:46,667,116...46,758,306
Ensembl chr20:46,667,121...46,758,305
JBrowse link
G Sesn2 sestrin 2 multiple interactions
decreases expression
ISO
EXP
[Metformin co-treated with Rotenone] results in increased expression of SESN2 protein
Metformin results in decreased expression of SESN2 mRNA
CTD PMID:26031332, PMID:31324951 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
JBrowse link
G Setx senataxin decreases expression EXP Metformin results in decreased expression of SETX mRNA CTD PMID:25596134 NCBI chr 3:7,680,430...7,731,815
Ensembl chr 3:7,686,503...7,730,539
JBrowse link
G Sez6 seizure related 6 homolog decreases expression EXP Metformin results in decreased expression of SEZ6 mRNA CTD PMID:31324951 NCBI chr10:64,865,802...64,915,461
Ensembl chr10:64,865,805...64,915,148
JBrowse link
G Sfn stratifin increases expression EXP Metformin results in increased expression of SFN mRNA CTD PMID:25596134 NCBI chr 5:151,823,422...151,824,937
Ensembl chr 5:151,823,887...151,824,633
JBrowse link
G Sgk1 serum/glucocorticoid regulated kinase 1 affects expression EXP Metformin affects the expression of SGK1 mRNA CTD PMID:31324951 NCBI chr 1:24,185,451...24,302,309
Ensembl chr 1:24,185,435...24,302,298
JBrowse link
G Sgk2 serum/glucocorticoid regulated kinase 2 increases expression EXP Metformin results in increased expression of SGK2 mRNA CTD PMID:31324951 NCBI chr 3:159,361,313...159,385,843
Ensembl chr 3:159,368,273...159,384,775
JBrowse link
G Sh3bp5 SH3-domain binding protein 5 decreases expression EXP Metformin results in decreased expression of SH3BP5 mRNA CTD PMID:31324951 NCBI chr16:7,473,367...7,559,976
Ensembl chr16:7,473,370...7,538,201
JBrowse link
G Siah2 siah E3 ubiquitin protein ligase 2 decreases expression EXP Metformin results in decreased expression of SIAH2 mRNA CTD PMID:25596134 NCBI chr 2:148,874,151...148,891,900
Ensembl chr 2:148,874,151...148,891,900
JBrowse link
G Sik1 salt-inducible kinase 1 decreases expression EXP Metformin results in decreased expression of SIK1 mRNA CTD PMID:25596134, PMID:31324951 NCBI chr20:10,670,747...10,680,279
Ensembl chr20:10,668,411...10,680,283
JBrowse link
G Sirt1 sirtuin 1 multiple interactions
increases expression
ISO
EXP
SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA]
Metformin results in increased expression of SIRT1 mRNA
Metformin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]
Metformin results in increased expression of SIRT1 protein
[Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Metformin; Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]; Metformin promotes the reaction [Arsenic Trioxide results in increased expression of SIRT1 protein]
CTD PMID:23090186, PMID:23166782, PMID:23315983, PMID:24428821, PMID:24687991, PMID:25108154, PMID:31332900 NCBI chr20:26,831,971...26,851,587
Ensembl chr20:26,833,357...26,852,199
JBrowse link
G Sirt2 sirtuin 2 increases expression ISO Metformin results in increased expression of SIRT2 mRNA; Metformin results in increased expression of SIRT2 protein CTD PMID:24687991 NCBI chr 1:86,948,866...86,971,954
Ensembl chr 1:86,948,918...86,971,952
JBrowse link
G Sirt3 sirtuin 3 multiple interactions
increases expression
decreases expression
decreases response to substance
ISO
EXP
Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]; SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate]
[Arsenic Trioxide co-treated with Metformin] results in increased expression of SIRT3 protein
Metformin results in increased expression of SIRT3 protein
Metformin results in decreased expression of SIRT3 mRNA; Metformin results in decreased expression of SIRT3 protein
SIRT3 protein results in decreased susceptibility to Metformin
CTD PMID:23166782, PMID:24687991, PMID:30385301 NCBI chr 1:213,613,502...213,636,061
Ensembl chr 1:213,613,513...213,635,546
JBrowse link
G Sirt4 sirtuin 4 increases expression ISO Metformin results in increased expression of SIRT4 mRNA CTD PMID:24687991 NCBI chr12:46,862,358...46,876,593
Ensembl chr12:46,868,416...46,876,592
JBrowse link
G Sirt5 sirtuin 5 decreases expression ISO Metformin results in decreased expression of SIRT5 protein CTD PMID:24687991 NCBI chr17:23,986,710...24,013,854
Ensembl chr17:23,986,758...24,013,881
JBrowse link
G Sirt7 sirtuin 7 decreases expression ISO Metformin results in decreased expression of SIRT7 mRNA CTD PMID:24687991 NCBI chr10:109,796,046...109,802,821
Ensembl chr10:109,796,020...109,802,739
JBrowse link
G Siva1 SIVA1, apoptosis-inducing factor decreases expression EXP Metformin results in decreased expression of SIVA1 mRNA CTD PMID:25596134 NCBI chr 6:137,209,999...137,214,379
Ensembl chr 6:137,210,052...137,214,388
JBrowse link
G Skp2 S-phase kinase associated protein 2 multiple interactions ISO Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of SKP2 mRNA] CTD PMID:29095437 NCBI chr 2:58,506,146...58,534,211
Ensembl chr 2:58,506,151...58,534,211
JBrowse link
G Slc12a8 solute carrier family 12, member 8 increases expression EXP Metformin results in increased expression of SLC12A8 mRNA CTD PMID:25596134 NCBI chr11:70,344,771...70,499,202
Ensembl chr11:70,344,797...70,499,200
JBrowse link
G Slc15a1 solute carrier family 15 member 1 multiple interactions
increases expression
ISO Metformin inhibits the reaction [rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein]; Metformin results in decreased activity of and results in decreased expression of SLC15A1 protein
Metformin results in increased expression of SLC15A1 mRNA
Metformin inhibits the reaction [rosiglitazone results in increased activity of SLC15A1 protein]
CTD PMID:22108913 NCBI chr15:106,800,081...106,844,668
Ensembl chr15:106,800,081...106,844,426
JBrowse link
G Slc16a10 solute carrier family 16 member 10 decreases expression EXP Metformin results in decreased expression of SLC16A10 mRNA CTD PMID:31324951 NCBI chr20:45,138,433...45,260,155
Ensembl chr20:45,143,453...45,260,119
JBrowse link
G Slc16a6 solute carrier family 16, member 6 increases expression EXP Metformin results in increased expression of SLC16A6 mRNA CTD PMID:25596134 NCBI chr10:97,733,701...97,758,723
Ensembl chr10:97,735,548...97,756,521
JBrowse link
G Slc19a2 solute carrier family 19 member 2 decreases expression EXP Metformin results in decreased expression of SLC19A2 mRNA CTD PMID:31324951 NCBI chr13:82,552,586...82,566,586
Ensembl chr13:82,552,550...82,566,586
JBrowse link
G Slc19a3 solute carrier family 19 member 3 multiple interactions
increases uptake
ISO Amprolium inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]; Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Verapamil inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin] CTD PMID:26528626 NCBI chr 9:88,762,775...88,828,553
Ensembl chr 9:88,764,073...88,816,898
JBrowse link
G Slc1a4 solute carrier family 1 member 4 increases expression EXP Metformin results in increased expression of SLC1A4 mRNA CTD PMID:25596134 NCBI chr14:104,582,884...104,612,417
Ensembl chr14:104,581,190...104,612,597