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G |
Aacs |
acetoacetyl-CoA synthetase |
increases expression |
EXP |
Metformin results in increased expression of AACS mRNA |
CTD |
PMID:31324951 |
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NCBI chr12:31,113,098...31,156,411
Ensembl chr12:31,113,098...31,160,954
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G |
Aars1 |
alanyl-tRNA synthetase 1 |
increases expression |
EXP |
Metformin results in increased expression of AARS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr19:38,999,130...39,021,152
Ensembl chr19:38,999,163...39,021,147
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G |
Abcb11 |
ATP binding cassette subfamily B member 11 |
decreases expression multiple interactions |
EXP ISO |
Metformin results in decreased expression of ABCB11 mRNA [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of ABCB11 protein |
CTD |
PMID:27765674 PMID:34058177 |
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NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions decreases expression |
ISO |
Metformin inhibits the reaction [Doxorubicin results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [RELA protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 protein]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of ABCB1 protein] Metformin results in decreased expression of ABCB1 mRNA; Metformin results in decreased expression of ABCB1 protein |
CTD |
PMID:21054339 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcb1b |
ATP-binding cassette, sub-family B member 1B |
increases expression |
EXP |
Metformin results in increased expression of ABCB1B mRNA |
CTD |
PMID:19022234 |
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NCBI chr 4:25,242,761...25,325,194
Ensembl chr 4:25,242,798...25,325,199
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G |
Abcb4 |
ATP binding cassette subfamily B member 4 |
increases expression |
EXP |
Metformin results in increased expression of ABCB4 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 4:25,150,998...25,209,489
Ensembl chr 4:25,151,953...25,209,202
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G |
Abcb6 |
ATP binding cassette subfamily B member 6 |
decreases expression |
EXP |
Metformin results in decreased expression of ABCB6 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924
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G |
Abcb9 |
ATP binding cassette subfamily B member 9 |
affects expression |
EXP |
Metformin affects the expression of ABCB9 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:32,499,213...32,531,932
Ensembl chr12:32,499,225...32,531,931
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G |
Abcc2 |
ATP binding cassette subfamily C member 2 |
increases expression |
ISO |
Metformin results in increased expression of ABCC2 mRNA |
CTD |
PMID:19022234 |
|
NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
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G |
Abcc3 |
ATP binding cassette subfamily C member 3 |
decreases expression |
EXP |
Metformin results in decreased expression of ABCC3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
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G |
Abcc4 |
ATP binding cassette subfamily C member 4 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Ethinyl Estradiol results in increased expression of ABCC4 protein] |
CTD |
PMID:34058177 |
|
NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
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G |
Abcc5 |
ATP binding cassette subfamily C member 5 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ABCC5 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253
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G |
Abcc9 |
ATP binding cassette subfamily C member 9 |
multiple interactions |
ISO |
[rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 mRNA alternative form; [rosiglitazone co-treated with Metformin] results in increased expression of ABCC9 protein alternative form |
CTD |
PMID:20823565 |
|
NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356
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G |
Abcg5 |
ATP binding cassette subfamily G member 5 |
decreases expression increases expression |
EXP |
Metformin results in decreased expression of ABCG5 mRNA Metformin results in increased expression of ABCG5 mRNA |
CTD |
PMID:27765674 PMID:31324951 |
|
NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
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G |
Abcg8 |
ATP binding cassette subfamily G member 8 |
increases expression |
EXP |
Metformin results in increased expression of ABCG8 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912
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G |
Abhd4 |
abhydrolase domain containing 4, N-acyl phospholipase B |
decreases expression |
EXP |
Metformin results in decreased expression of ABHD4 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr15:27,697,384...27,716,013
Ensembl chr15:27,704,113...27,716,966
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G |
Abl1 |
ABL proto-oncogene 1, non-receptor tyrosine kinase |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of ABL1 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
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G |
Ablim3 |
actin binding LIM protein family, member 3 |
increases expression |
EXP |
Metformin results in increased expression of ABLIM3 mRNA |
CTD |
PMID:31324951 |
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NCBI chr18:55,256,135...55,376,629
Ensembl chr18:55,257,583...55,376,380
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G |
Acaca |
acetyl-CoA carboxylase alpha |
decreases expression increases phosphorylation affects phosphorylation multiple interactions increases expression |
ISO EXP |
Metformin results in decreased expression of ACACA mRNA; Metformin results in decreased expression of ACACA protein Metformin results in increased phosphorylation of ACACA protein Metformin analog affects the phosphorylation of ACACA protein Trientine inhibits the reaction [Metformin results in increased phosphorylation of ACACA protein] Metformin results in increased expression of ACACA mRNA Metformin inhibits the reaction [Olanzapine results in decreased expression of ACACA mRNA] Metformin results in increased expression of ACACA protein modified form Metformin inhibits the reaction [INS protein results in increased phosphorylation of ACACA protein] |
CTD |
PMID:16760380 PMID:16873680 PMID:20956498 PMID:22492524 PMID:29991592 PMID:31324951 PMID:32652086 PMID:33838154 PMID:36764371 More...
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NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
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G |
Acacb |
acetyl-CoA carboxylase beta |
increases phosphorylation |
ISO |
Metformin results in increased phosphorylation of ACACB protein |
CTD |
PMID:16873680 |
|
NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655
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G |
Acat2 |
acetyl-CoA acetyltransferase 2 |
increases expression |
EXP |
Metformin results in increased expression of ACAT2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821
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G |
Ace |
angiotensin I converting enzyme |
multiple interactions |
ISO |
Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of ACE mRNA] |
CTD |
PMID:37120126 |
|
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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G |
Ace2 |
angiotensin converting enzyme 2 |
increases expression multiple interactions |
ISO |
Metformin results in increased expression of ACE2 mRNA Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of ACE2 mRNA] |
CTD |
PMID:32808185 PMID:37120126 |
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NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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G |
Ache |
acetylcholinesterase |
decreases activity multiple interactions |
ISO EXP |
Metformin results in decreased activity of ACHE protein Metformin inhibits the reaction [[Fructose co-treated with Streptozocin] results in increased expression of ACHE protein]; Metformin inhibits the reaction [Chlorpyrifos results in decreased activity of ACHE protein] |
CTD |
PMID:28259689 PMID:33823243 PMID:35448458 |
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NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651
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G |
Acly |
ATP citrate lyase |
multiple interactions affects expression |
ISO EXP |
[Metformin co-treated with caffeic acid] results in decreased expression of ACLY protein Metformin affects the expression of ACLY mRNA |
CTD |
PMID:28576465 PMID:31324951 |
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NCBI chr10:85,412,045...85,464,253
Ensembl chr10:85,412,049...85,463,320
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G |
Acmsd |
aminocarboxymuconate semialdehyde decarboxylase |
decreases expression |
EXP |
Metformin results in decreased expression of ACMSD mRNA |
CTD |
PMID:31324951 |
|
NCBI chr13:39,200,412...39,245,954
Ensembl chr13:39,200,314...39,245,209
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G |
Acot2 |
acyl-CoA thioesterase 2 |
increases expression |
EXP |
Metformin results in increased expression of ACOT2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 6:103,611,738...103,619,404
Ensembl chr 6:103,611,544...103,619,245
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G |
Acot3 |
acyl-CoA thioesterase 3 |
increases expression |
EXP |
Metformin results in increased expression of ACOT3 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 6:103,682,518...103,688,735
Ensembl chr 6:103,682,596...103,688,427 Ensembl chr 6:103,682,596...103,688,427
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G |
Acsl1 |
acyl-CoA synthetase long-chain family member 1 |
decreases expression multiple interactions |
EXP ISO |
Metformin results in decreased expression of ACSL1 mRNA Metformin inhibits the reaction [Oxygen deficiency results in increased expression of ACSL1 mRNA] |
CTD |
PMID:25596134 PMID:33476677 |
|
NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
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G |
Acsm3 |
acyl-CoA synthetase medium-chain family member 3 |
increases expression |
EXP |
Metformin results in increased expression of ACSM3 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:174,133,260...174,159,966
Ensembl chr 1:174,133,288...174,160,184
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G |
Acta1 |
actin, alpha 1, skeletal muscle |
increases expression |
EXP |
Metformin results in increased expression of ACTA1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr19:51,883,709...51,886,735
Ensembl chr19:51,883,715...51,886,742
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
EXP |
Metformin inhibits the reaction [Dietary Fats results in increased expression of ACTA2 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of ACTA2 protein]] |
CTD |
PMID:27551045 PMID:30551545 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Actn1 |
actinin, alpha 1 |
increases expression |
EXP |
Metformin results in increased expression of ACTN1 mRNA |
CTD |
PMID:19022234 |
|
NCBI chr 6:98,998,553...99,093,334
Ensembl chr 6:98,998,556...99,093,251
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G |
Adgre1 |
adhesion G protein-coupled receptor E1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Folic Acid results in increased expression of ADGRE1 mRNA] |
CTD |
PMID:29380373 |
|
NCBI chr 9:2,242,476...2,398,000
Ensembl chr 9:2,242,474...2,398,000
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G |
Adh4 |
alcohol dehydrogenase 4 (class II), pi polypeptide |
decreases expression |
EXP |
Metformin results in decreased expression of ADH4 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
decreases expression multiple interactions increases expression |
ISO EXP |
Metformin results in decreased expression of ADIPOQ mRNA Cimetidine promotes the reaction [Metformin results in decreased expression of ADIPOQ mRNA] Metformin inhibits the reaction [Fructose results in decreased expression of ADIPOQ protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of ADIPOQ mRNA] Metformin results in increased expression of ADIPOQ protein Metformin inhibits the reaction [Olanzapine results in decreased expression of ADIPOQ protein] |
CTD |
PMID:20956498 PMID:25108154 PMID:30256492 PMID:32652086 |
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NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Adipor1 |
adiponectin receptor 1 |
increases expression |
EXP |
Metformin results in increased expression of ADIPOR1 mRNA |
CTD |
PMID:29991592 |
|
NCBI chr13:45,859,461...45,879,248
Ensembl chr13:45,859,533...45,879,241
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G |
Adipor2 |
adiponectin receptor 2 |
increases expression |
EXP |
metformin increases expression of Adipor2 mRNA in liver |
RGD |
PMID:24797033 |
RGD:25824940 |
NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
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G |
Aen |
apoptosis enhancing nuclease |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of AEN mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 1:132,815,094...132,824,522
Ensembl chr 1:132,815,142...132,824,523
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G |
Ager |
advanced glycosylation end product-specific receptor |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of AGER protein]; Metformin inhibits the reaction [Glucose promotes the reaction [Linoleic Acid promotes the reaction [Azoxymethane results in increased expression of AGER protein]]]; Metformin inhibits the reaction [Linoleic Acid promotes the reaction [Glucose promotes the reaction [Azoxymethane results in increased expression of AGER protein]]] |
CTD |
PMID:22467055 PMID:36999408 |
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NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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G |
Agrn |
agrin |
decreases expression |
EXP |
Metformin results in decreased expression of AGRN mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:166,749,306...166,782,212
Ensembl chr 5:166,749,310...166,786,003
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G |
Agrp |
agouti related neuropeptide |
multiple interactions |
ISO |
Metformin inhibits the reaction [Olanzapine results in increased expression of AGRP mRNA] |
CTD |
PMID:32652086 |
|
NCBI chr19:33,447,992...33,481,602
Ensembl chr19:33,447,992...33,449,584
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G |
Agt |
angiotensinogen |
multiple interactions |
ISO |
Metformin inhibits the reaction [AGT protein results in increased activity of and results in increased phosphorylation of HMGCR protein]; Metformin inhibits the reaction [AGT protein results in increased cleavage of and affects the localization of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased expression of LDLR protein]; Metformin inhibits the reaction [AGT protein results in increased expression of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of TNF protein] |
CTD |
PMID:29499335 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Agtr1a |
angiotensin II receptor, type 1a |
multiple interactions |
ISO |
Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of AGTR1A mRNA] |
CTD |
PMID:37120126 |
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NCBI chr17:34,173,446...34,226,892
Ensembl chr17:34,174,429...34,226,946
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G |
Ahr |
aryl hydrocarbon receptor |
decreases expression multiple interactions affects activity |
ISO EXP |
Metformin results in decreased expression of AHR mRNA; Metformin results in decreased expression of AHR protein Metformin inhibits the reaction [SP1 protein results in increased expression of AHR protein]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein] Metformin affects the activity of AHR protein |
CTD |
PMID:25110054 PMID:25596134 PMID:25697376 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Acetaminophen affects the localization of AIFM1 protein] |
CTD |
PMID:27562556 |
|
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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G |
Aifm2 |
apoptosis inducing factor, mitochondria associated 2 |
decreases expression |
EXP |
Metformin results in decreased expression of AIFM2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr20:29,654,283...29,679,239
Ensembl chr20:29,652,927...29,679,236
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G |
Ak3 |
adenylate kinase 3 |
decreases expression |
EXP |
Metformin results in decreased expression of AK3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625
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G |
Ak4 |
adenylate kinase 4 |
decreases expression |
EXP |
Metformin results in decreased expression of AK4 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618
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G |
Akr1b8-ps2 |
aldo-keto reductase family 1, member B8, pseudogene 2 |
decreases expression |
EXP |
Metformin results in decreased expression of AKR1B8-PS2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 6:77,569,720...77,571,967
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases phosphorylation increases phosphorylation affects phosphorylation |
ISO EXP |
[Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with INS protein] results in increased phosphorylation of AKT1 protein; [Paclitaxel co-treated with Metformin] results in decreased expression of AKT1 mRNA; [Simvastatin co-treated with Metformin] results in decreased phosphorylation of AKT1 protein; AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of AKT1 protein]]; AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]]; Metformin inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of AKT1 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of AKT1 mRNA]; Metformin inhibits the reaction [Testosterone results in increased phosphorylation of AKT1 protein] Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [Olanzapine results in decreased expression of AKT1 mRNA] Metformin decreases phosphorylation of AKT1 protein in epithelial cell of alveolus of lung Metformin results in increased phosphorylation of AKT1 protein Metformin affects the phosphorylation of AKT1 protein |
CTD RGD |
PMID:16385087 PMID:21664031 PMID:25412314 PMID:26492952 PMID:26835874 PMID:29309887 PMID:30742852 PMID:30914352 PMID:30928401 PMID:31743741 PMID:31877369 PMID:32652086 PMID:35199402 PMID:35350904 PMID:35414346 PMID:36764371 PMID:23632475 More...
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RGD:150404268 |
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Akt2 |
AKT serine/threonine kinase 2 |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of AKT2 protein] |
CTD |
PMID:27270450 |
|
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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G |
Akt3 |
AKT serine/threonine kinase 3 |
decreases expression |
ISO |
Metformin results in decreased expression of AKT3 mRNA |
CTD |
PMID:32589349 |
|
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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G |
Alas2 |
5'-aminolevulinate synthase 2 |
decreases expression |
EXP |
Metformin results in decreased expression of ALAS2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519
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G |
Alb |
albumin |
multiple interactions |
EXP |
Metformin inhibits the reaction [Streptozocin results in increased expression of ALB protein] |
CTD |
PMID:33639173 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Aldh18a1 |
aldehyde dehydrogenase 18 family, member A1 |
increases expression |
EXP |
Metformin results in increased expression of ALDH18A1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:239,375,657...239,407,956
Ensembl chr 1:239,375,669...239,407,890
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G |
Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
EXP |
Metformin results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
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G |
Aldoa |
aldolase, fructose-bisphosphate A |
increases expression |
EXP |
Metformin results in increased expression of ALDOA mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
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G |
Alox15 |
arachidonate 15-lipoxygenase |
decreases expression |
EXP |
Metformin results in decreased expression of ALOX15 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874
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G |
Alpl |
alkaline phosphatase, biomineralization associated |
multiple interactions |
ISO |
Metformin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA] |
CTD |
PMID:37409753 |
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NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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G |
Ambp |
alpha-1-microglobulin/bikunin precursor |
decreases expression |
EXP |
Metformin results in decreased expression of AMBP mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:76,568,094...76,578,416
Ensembl chr 5:76,568,094...76,578,331
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G |
Angpt1 |
angiopoietin 1 |
decreases expression |
EXP |
Metformin results in decreased expression of ANGPT1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:73,528,345...73,783,953
Ensembl chr 7:73,531,486...73,784,067
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G |
Angptl4 |
angiopoietin-like 4 |
decreases expression increases expression |
EXP |
Metformin results in decreased expression of ANGPTL4 mRNA Metformin results in increased expression of ANGPTL4 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
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NCBI chr 7:14,550,288...14,557,797
Ensembl chr 7:14,550,311...14,556,519
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G |
Angptl8 |
angiopoietin-like 8 |
increases expression |
EXP |
Metformin results in increased expression of ANGPTL8 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:20,376,462...20,378,490
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G |
Apaf1 |
apoptotic peptidase activating factor 1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of APAF1 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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G |
Apex1 |
apurinic/apyrimidinic endodeoxyribonuclease 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of APEX1 mRNA] |
CTD |
PMID:25697376 |
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NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
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G |
Apoa5 |
apolipoprotein A5 |
decreases expression |
EXP |
Metformin results in decreased expression of APOA5 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816
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G |
Apof |
apolipoprotein F |
decreases expression |
EXP |
Metformin results in decreased expression of APOF mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:700,688...702,130
Ensembl chr 7:700,762...701,946
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G |
Appl1 |
adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 |
multiple interactions increases expression |
EXP |
Metformin promotes the reaction [APPL1 protein binds to RAB5A protein] Metformin results in increased expression of APPL1 protein |
CTD |
PMID:29991592 |
|
NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
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G |
Aqp7 |
aquaporin 7 |
increases expression |
EXP |
Metformin results in increased expression of AQP7 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 5:56,171,649...56,186,642
Ensembl chr 5:56,172,519...56,186,642
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G |
Arfgap3 |
ADP-ribosylation factor GTPase activating protein 3 |
increases expression |
EXP |
Metformin results in increased expression of ARFGAP3 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:114,432,873...114,479,206
Ensembl chr 7:114,432,873...114,479,208
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G |
Arfgef2 |
ADP ribosylation factor guanine nucleotide exchange factor 2 |
increases expression |
EXP |
Metformin results in increased expression of ARFGEF2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:155,547,504...155,633,652
Ensembl chr 3:155,547,538...155,630,856
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G |
Arg1 |
arginase 1 |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [Palmitic Acid results in decreased expression of ARG1 mRNA] Metformin inhibits the reaction [IL13 protein results in increased expression of ARG1 mRNA] |
CTD |
PMID:25108154 PMID:26497364 |
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NCBI chr 1:20,475,878...20,488,422
Ensembl chr 1:20,475,968...20,488,422
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G |
Arhgef10 |
Rho guanine nucleotide exchange factor 10 |
decreases expression |
EXP |
Metformin results in decreased expression of ARHGEF10 mRNA |
CTD |
PMID:25596134 |
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NCBI chr16:74,647,147...74,738,784
Ensembl chr16:74,647,153...74,738,173
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G |
Arl1 |
ADP-ribosylation factor like GTPase 1 |
decreases expression |
EXP |
Metformin results in decreased expression of ARL1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 7:23,120,004...23,131,173
Ensembl chr 7:23,119,589...23,131,898
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G |
Arpc5l |
actin related protein 2/3 complex, subunit 5-like |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ARPC5L mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538 Ensembl chr 9:22,759,876...22,767,538
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G |
Arrdc3 |
arrestin domain containing 3 |
decreases expression |
EXP |
Metformin results in decreased expression of ARRDC3 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 2:11,137,464...11,149,978
Ensembl chr 2:11,137,460...11,149,978
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G |
Asl |
argininosuccinate lyase |
decreases expression |
EXP |
Metformin results in decreased expression of ASL mRNA |
CTD |
PMID:31324951 |
|
NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
EXP |
Metformin results in increased expression of ASNS mRNA |
CTD |
PMID:25596134 PMID:31324951 |
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NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423
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G |
Atf3 |
activating transcription factor 3 |
increases expression |
EXP |
Metformin results in increased expression of ATF3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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G |
Atf4 |
activating transcription factor 4 |
affects activity multiple interactions |
EXP ISO |
Metformin affects the activity of ATF4 protein Metformin inhibits the reaction [Rotenone results in increased expression of ATF4 mRNA] |
CTD |
PMID:25596134 PMID:32189544 |
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NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
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G |
Atf5 |
activating transcription factor 5 |
increases expression |
EXP |
Metformin results in increased expression of ATF5 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:95,295,602...95,299,755
Ensembl chr 1:95,295,610...95,299,707
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G |
Atf6 |
activating transcription factor 6 |
multiple interactions |
ISO EXP |
Metformin inhibits the reaction [Rotenone results in increased expression of ATF6 mRNA] Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of ATF6 protein]; Metformin inhibits the reaction [Glucose results in increased expression of and affects the localization of ATF6 protein] |
CTD |
PMID:32189544 PMID:34801538 |
|
NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G |
Atm |
ATM serine/threonine kinase |
affects response to substance increases expression |
ISO |
ATM gene SNP affects the susceptibility to Metformin Metformin increases expression of ATM protein in epithelial cell of alveolus of lung |
CTD RGD |
PMID:21186350 PMID:23632475 |
RGD:150404268 |
NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
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G |
Atosa |
atos homolog A |
decreases expression |
EXP |
Metformin results in decreased expression of ATOSA mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 8:75,694,828...75,772,565
Ensembl chr 8:75,695,022...75,772,549
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G |
Atp1a2 |
ATPase Na+/K+ transporting subunit alpha 2 |
decreases expression |
EXP |
Metformin results in decreased expression of ATP1A2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr13:84,729,597...84,754,544
Ensembl chr13:84,729,601...84,754,544
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G |
Atp1a3 |
ATPase Na+/K+ transporting subunit alpha 3 |
increases expression |
EXP |
Metformin results in increased expression of ATP1A3 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:80,572,790...80,601,936
Ensembl chr 1:80,572,796...80,601,918
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G |
Atp2a2 |
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of ATP2A2 protein] |
CTD |
PMID:30290168 |
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NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
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G |
Atp5mc2 |
ATP synthase membrane subunit c locus 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ATP5MC2 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 7:133,791,341...133,799,713
Ensembl chr 7:133,791,342...133,799,733
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G |
Atp6v0d2 |
ATPase H+ transporting V0 subunit D2 |
decreases expression |
EXP |
Metformin results in decreased expression of ATP6V0D2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 5:33,336,257...33,385,354
Ensembl chr 5:33,336,264...33,385,354
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G |
Atr |
ATR serine/threonine kinase |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of ATR mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 8:96,426,704...96,524,152
Ensembl chr 8:96,426,724...96,524,136
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G |
Aurkb |
aurora kinase B |
increases expression |
EXP |
Metformin results in increased expression of AURKB mRNA |
CTD |
PMID:25596134 |
|
NCBI chr10:53,744,290...53,750,831
Ensembl chr10:53,745,142...53,750,837
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G |
Aven |
apoptosis and caspase activation inhibitor |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of AVEN mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 3:99,299,009...99,431,635
Ensembl chr 3:99,298,930...99,431,634
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G |
B2m |
beta-2 microglobulin |
multiple interactions |
EXP |
Metformin inhibits the reaction [Streptozocin results in increased expression of B2M protein] |
CTD |
PMID:33639173 |
|
NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
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G |
Bad |
BCL2-associated agonist of cell death |
increases expression multiple interactions |
ISO |
Metformin results in increased expression of BAD protein Cisplatin promotes the reaction [Metformin results in increased expression of BAD protein]; Metformin inhibits the reaction [INS protein results in decreased expression of BAD protein] |
CTD |
PMID:21388661 PMID:33651899 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bag1 |
BAG cochaperone 1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of BAG1 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 5:56,068,494...56,081,075
Ensembl chr 5:56,068,494...56,081,075
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression affects expression |
ISO EXP |
Cisplatin promotes the reaction [Metformin results in increased expression of BAX protein] Metformin results in increased expression of BAX mRNA Metformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]; Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]; Metformin inhibits the reaction [Glucose results in increased expression of BAX protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BAX mRNA]; Metformin inhibits the reaction [Testosterone results in decreased expression of BAX mRNA] Metformin affects the expression of BAX protein SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]] |
CTD |
PMID:21388661 PMID:25596134 PMID:26492952 PMID:28106847 PMID:29226720 PMID:30144576 PMID:35414346 PMID:36800006 More...
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcar3 |
BCAR3 adaptor protein, NSP family member |
affects expression |
EXP |
Metformin affects the expression of BCAR3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 2:210,525,260...210,638,674
Ensembl chr 2:210,525,260...210,638,798
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G |
Bcat2 |
branched chain amino acid transaminase 2 |
decreases expression |
EXP |
Metformin results in decreased expression of BCAT2 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
|
NCBI chr 1:96,040,407...96,060,008
Ensembl chr 1:96,042,625...96,060,007
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression multiple interactions |
ISO EXP |
Metformin results in decreased expression of BCL2 protein [Paclitaxel co-treated with Metformin] results in decreased expression of BCL2 mRNA; Cisplatin promotes the reaction [Metformin results in decreased expression of BCL2 protein] Metformin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]; Metformin inhibits the reaction [Glucose results in decreased expression of BCL2 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BCL2 mRNA]; Metformin inhibits the reaction [Testosterone results in increased expression of BCL2 mRNA] |
CTD |
PMID:21388661 PMID:26492952 PMID:26818447 PMID:28106847 PMID:29226720 PMID:29309887 PMID:30144576 PMID:34801538 PMID:35414346 More...
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions decreases expression |
ISO EXP |
Cisplatin promotes the reaction [Metformin results in decreased expression of BCL2L1 protein] Metformin inhibits the reaction [Streptozocin results in increased expression of BCL2L1 mRNA] |
CTD |
PMID:21388661 PMID:35414346 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Bcl6 |
BCL6, transcription repressor |
increases expression |
EXP |
Metformin results in increased expression of BCL6 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr11:76,854,090...76,877,389
Ensembl chr11:76,854,090...76,877,389
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G |
Bdnf |
brain-derived neurotrophic factor |
multiple interactions |
EXP |
Metformin inhibits the reaction [Methamphetamine results in decreased expression of BDNF protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of BDNF mRNA] |
CTD |
PMID:30742852 PMID:35414346 |
|
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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G |
Becn1 |
beclin 1 |
increases expression multiple interactions |
ISO |
Metformin results in increased expression of BECN1 protein plantamajoside promotes the reaction [Metformin results in increased expression of BECN1 protein] |
CTD |
PMID:35350904 |
|
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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G |
Bhlhe40 |
basic helix-loop-helix family, member e40 |
affects expression |
EXP |
Metformin affects the expression of BHLHE40 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
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G |
Birc5 |
baculoviral IAP repeat-containing 5 |
decreases expression |
ISO |
Metformin results in decreased expression of BIRC5 protein |
CTD |
PMID:29226720 |
|
NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
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G |
Bmal1 |
basic helix-loop-helix ARNT like 1 |
decreases expression |
EXP |
Metformin results in decreased expression of BMAL1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231
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G |
Bmf |
Bcl2 modifying factor |
decreases expression |
EXP |
Metformin results in decreased expression of BMF mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 3:105,499,534...105,520,159
Ensembl chr 3:105,499,538...105,520,145
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G |
Bmp2 |
bone morphogenetic protein 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [BMP2 protein results in decreased expression of CDH1 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of ALPL mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of BMP4 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 protein]; Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 protein]; Metformin inhibits the reaction [BMP2 protein results in increased expression of VIM mRNA] |
CTD |
PMID:37409753 |
|
NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397
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G |
Bmp4 |
bone morphogenetic protein 4 |
multiple interactions |
ISO |
Metformin inhibits the reaction [BMP2 protein results in increased expression of BMP4 mRNA] |
CTD |
PMID:37409753 |
|
NCBI chr15:19,618,538...19,633,494
Ensembl chr15:19,618,542...19,623,306
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G |
Bnip3 |
BCL2 interacting protein 3 |
increases expression |
EXP |
Metformin results in increased expression of BNIP3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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G |
Bpgm |
bisphosphoglycerate mutase |
decreases expression |
EXP |
Metformin results in decreased expression of BPGM mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581
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G |
Brd2 |
bromodomain containing 2 |
affects expression |
EXP |
Metformin affects the expression of BRD2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr20:4,727,078...4,735,389
Ensembl chr20:4,728,151...4,735,388
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G |
Btg2 |
BTG anti-proliferation factor 2 |
affects expression decreases expression |
EXP |
Metformin affects the expression of BTG2 mRNA Metformin results in decreased expression of BTG2 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
|
NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
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G |
Bub1b |
BUB1 mitotic checkpoint serine/threonine kinase B |
affects expression |
ISO |
Metformin affects the expression of BUB1B mRNA |
CTD |
PMID:35568294 |
|
NCBI chr 3:105,563,089...105,615,547
Ensembl chr 3:105,563,138...105,615,547
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G |
Cacna1d |
calcium voltage-gated channel subunit alpha1 D |
decreases expression |
EXP |
Metformin results in decreased expression of CACNA1D mRNA |
CTD |
PMID:25596134 |
|
NCBI chr16:5,227,157...5,521,163
Ensembl chr16:5,228,306...5,668,215
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G |
Canx |
calnexin |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of CANX protein] |
CTD |
PMID:34801538 |
|
NCBI chr10:34,623,865...34,656,866
Ensembl chr10:34,625,191...34,656,821
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G |
Cars1 |
cysteinyl-tRNA synthetase 1 |
increases expression |
EXP |
Metformin results in increased expression of CARS1 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
|
NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO EXP |
[Paclitaxel co-treated with Metformin] results in increased expression of CASP1 mRNA Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased cleavage of CASP1 protein] |
CTD |
PMID:29309887 PMID:36999408 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp14 |
caspase 14 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of CASP14 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 7:10,929,759...10,932,591
Ensembl chr 7:10,926,725...10,933,405
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G |
Casp3 |
caspase 3 |
multiple interactions increases activity decreases activity increases expression increases cleavage |
ISO EXP |
[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA; Cisplatin promotes the reaction [Metformin results in increased activity of CASP3 protein]; Metformin inhibits the reaction [Sunitinib results in increased cleavage of CASP3 protein]; plantamajoside promotes the reaction [Metformin results in increased cleavage of CASP3 protein]; Sodium Salicylate promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of CASP3 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of CASP3 mRNA] Metformin results in decreased activity of CASP3 protein Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 mRNA]; Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of CASP3 protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein]; Metformin inhibits the reaction [Glucose results in increased activity of CASP3 protein]; Metformin inhibits the reaction [Glucose results in increased expression of and results in increased activity of CASP3 protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of CASP3 mRNA] Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CASP3 protein modified form]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]] |
CTD |
PMID:15531508 PMID:21388661 PMID:21906609 PMID:26818447 PMID:27551045 PMID:28106847 PMID:29095437 PMID:29117515 PMID:30144576 PMID:34801538 PMID:35199402 PMID:35350904 PMID:35414346 PMID:36800006 More...
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp4 |
caspase 4 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of CASP4 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G |
Casp7 |
caspase 7 |
multiple interactions increases activity |
ISO EXP |
Cisplatin promotes the reaction [Metformin results in increased activity of CASP7 protein]; Metformin inhibits the reaction [Sunitinib results in increased cleavage of CASP7 protein] dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CASP7 protein]] |
CTD |
PMID:21388661 PMID:21906609 PMID:30551545 |
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NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp8 |
caspase 8 |
decreases activity multiple interactions |
ISO |
Metformin results in decreased activity of CASP8 protein [Paclitaxel co-treated with Metformin] results in increased expression of CASP8 mRNA |
CTD |
PMID:15531508 PMID:29309887 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casq1 |
calsequestrin 1 |
decreases expression |
EXP |
Metformin results in decreased expression of CASQ1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr13:84,670,648...84,680,339
Ensembl chr13:84,670,649...84,680,339
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G |
Cat |
catalase |
multiple interactions increases expression decreases expression increases activity decreases activity |
EXP ISO |
Metformin inhibits the reaction [[Fructose co-treated with Streptozocin] results in decreased activity of CAT protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of CAT protein]; Metformin inhibits the reaction [Doxorubicin results in decreased expression of CAT mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased activity of CAT protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of CAT mRNA] Metformin results in increased expression of CAT mRNA Metformin results in decreased expression of CAT mRNA Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein]; Metformin promotes the reaction [Carbon Tetrachloride results in increased activity of CAT protein] Metformin results in increased activity of CAT protein Metformin results in decreased activity of CAT protein |
CTD |
PMID:15531508 PMID:21457706 PMID:22627169 PMID:22666520 PMID:24717679 PMID:29185360 PMID:30958922 PMID:33639173 PMID:33823243 PMID:35414346 PMID:36999408 PMID:37120126 More...
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cby1 |
chibby 1, beta catenin antagonist |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CBY1 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr 7:111,216,835...111,223,305
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G |
Ccdc38 |
coiled-coil domain containing 38 |
increases expression |
EXP |
Metformin results in increased expression of CCDC38 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:28,055,883...28,129,938
Ensembl chr 7:28,059,798...28,130,441
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G |
Ccdc77 |
coiled-coil domain containing 77 |
increases expression |
EXP |
Metformin results in increased expression of CCDC77 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 4:153,534,184...153,566,059
Ensembl chr 4:153,534,187...153,566,545
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G |
Ccdc90b |
coiled-coil domain containing 90B |
increases expression |
EXP |
Metformin results in increased expression of CCDC90B mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:146,632,756...146,646,314
Ensembl chr 1:146,633,036...146,647,338
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
decreases expression multiple interactions |
ISO EXP |
Metformin results in decreased expression of CCL2 mRNA Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of CCL2 mRNA] Metformin inhibits the reaction [AGT protein results in increased secretion of CCL2 protein]; Metformin inhibits the reaction [Folic Acid results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL2 mRNA] |
CTD |
PMID:20956498 PMID:25108154 PMID:26497364 PMID:29380373 PMID:29499335 PMID:30551545 PMID:33639173 More...
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Ccl24 |
C-C motif chemokine ligand 24 |
multiple interactions |
ISO |
Metformin inhibits the reaction [IL13 protein results in increased expression of CCL24 mRNA] |
CTD |
PMID:26497364 |
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NCBI chr12:21,100,835...21,104,832
Ensembl chr12:21,100,835...21,104,893
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G |
Ccl27 |
C-C motif chemokine ligand 27 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of CCL27A mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 5:56,941,402...56,948,511
Ensembl chr 5:56,941,402...56,948,506
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G |
Ccl7 |
C-C motif chemokine ligand 7 |
multiple interactions |
ISO |
Metformin inhibits the reaction [IL13 protein results in increased expression of CCL7 mRNA] |
CTD |
PMID:26497364 |
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NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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G |
Ccn2 |
cellular communication network factor 2 |
decreases expression |
EXP |
Metformin results in decreased expression of CCN2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734
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G |
Ccnb1 |
cyclin B1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNB1 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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G |
Ccnb2 |
cyclin B2 |
multiple interactions increases expression |
ISO EXP |
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNB2 mRNA Metformin results in increased expression of CCNB2 mRNA |
CTD |
PMID:29309887 PMID:31324951 |
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NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874
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G |
Ccnc |
cyclin C |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNC mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 5:35,266,828...35,284,943
Ensembl chr 5:35,266,823...35,296,584
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G |
Ccnd1 |
cyclin D1 |
multiple interactions decreases expression |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CCND1 mRNA Metformin results in decreased expression of CCND1 protein |
CTD |
PMID:29226720 PMID:29309887 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Ccnd2 |
cyclin D2 |
multiple interactions decreases expression |
EXP ISO |
Metformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein] Metformin results in decreased expression of CCND2 protein [Paclitaxel co-treated with Metformin] results in decreased expression of CCND2 mRNA |
CTD |
PMID:16760380 PMID:29309887 |
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NCBI chr 4:159,966,883...159,989,261
Ensembl chr 4:159,962,363...159,989,495
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G |
Ccne1 |
cyclin E1 |
multiple interactions decreases expression |
EXP ISO |
Metformin inhibits the reaction [FSHB protein results in increased expression of CCNE1 protein] Metformin results in decreased expression of CCNE1 protein [Paclitaxel co-treated with Metformin] results in decreased expression of CCNE1 mRNA |
CTD |
PMID:16760380 PMID:29309887 |
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NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Ccnf |
cyclin F |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CCNF mRNA |
CTD |
PMID:29309887 |
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NCBI chr10:13,253,073...13,279,140
Ensembl chr10:13,253,380...13,279,101
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G |
Ccng1 |
cyclin G1 |
increases expression multiple interactions |
EXP ISO |
Metformin results in increased expression of CCNG1 mRNA [Paclitaxel co-treated with Metformin] results in decreased expression of CCNG1 mRNA |
CTD |
PMID:19022234 PMID:29309887 |
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NCBI chr10:25,176,231...25,182,604
Ensembl chr10:25,176,234...25,181,641
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G |
Ccng2 |
cyclin G2 |
decreases expression multiple interactions |
ISO EXP |
Metformin results in decreased expression of CCNG2 mRNA [Paclitaxel co-treated with Metformin] results in decreased expression of CCNG2 mRNA |
CTD |
PMID:25596134 PMID:29309887 |
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NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
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G |
Ccr2 |
C-C motif chemokine receptor 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA] |
CTD |
PMID:26497364 |
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NCBI chr 8:123,734,465...123,742,483
Ensembl chr 8:123,734,430...123,742,100
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G |
Cd14 |
CD14 molecule |
increases expression |
ISO |
Metformin results in increased expression of CD14 protein |
CTD |
PMID:26036281 |
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NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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G |
Cd40lg |
CD40 ligand |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CD40LG mRNA |
CTD |
PMID:29309887 |
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NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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G |
Cd52 |
CD52 molecule |
decreases expression |
EXP |
Metformin results in decreased expression of CD52 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348
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G |
Cd63 |
Cd63 molecule |
increases expression |
EXP |
Metformin results in increased expression of CD63 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178
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G |
Cd74 |
CD74 molecule |
decreases expression |
EXP |
Metformin results in decreased expression of CD74 mRNA |
CTD |
PMID:31324951 |
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NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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G |
Cdc16 |
cell division cycle 16 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CDC16 mRNA |
CTD |
PMID:29309887 |
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NCBI chr16:75,773,026...75,796,586
Ensembl chr16:75,773,028...75,796,550
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G |
Cdc20 |
cell division cycle 20 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CDC20 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512
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G |
Cdc25a |
cell division cycle 25A |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CDC25A mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
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G |
Cdc25b |
cell division cycle 25B |
decreases expression |
EXP |
Metformin results in decreased expression of CDC25B mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 3:118,407,127...118,417,272
Ensembl chr 3:118,407,128...118,417,272
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G |
Cdc34 |
cell division cycle 34, ubiqiutin conjugating enzyme |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CDC34 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 7:10,017,588...10,023,586
Ensembl chr 7:10,017,588...10,023,186
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G |
Cdc42 |
cell division cycle 42 |
decreases expression |
ISO |
Metformin results in decreased expression of CDC42 mRNA |
CTD |
PMID:32589349 |
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NCBI chr 5:149,555,069...149,593,239
Ensembl chr 5:149,553,724...149,593,111
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G |
Cdh1 |
cadherin 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [BMP2 protein results in decreased expression of CDH1 mRNA] |
CTD |
PMID:37409753 |
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NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Cdip1 |
cell death-inducing p53 target 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CDIP1 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980
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G |
Cdk1 |
cyclin-dependent kinase 1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CDK1 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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G |
Cdk2 |
cyclin dependent kinase 2 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CDK2 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
multiple interactions increases expression |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CDK4 mRNA Metformin results in increased expression of CDK4 protein |
CTD |
PMID:29226720 PMID:29309887 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdk5r1 |
cyclin-dependent kinase 5 regulatory subunit 1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CDK5R1 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr10:65,484,266...65,485,467
Ensembl chr10:65,483,941...65,488,456
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G |
Cdk6 |
cyclin-dependent kinase 6 |
increases expression |
EXP |
Metformin results in increased expression of CDK6 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:30,637,650...30,829,688
Ensembl chr 4:30,646,460...30,829,634
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G |
Cdk7 |
cyclin-dependent kinase 7 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CDK7 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
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G |
Cdk8 |
cyclin-dependent kinase 8 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CDK8 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr12:8,737,198...8,805,026
Ensembl chr12:8,737,262...8,804,177
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression multiple interactions |
EXP |
Metformin results in increased expression of CDKN1A mRNA Metformin inhibits the reaction [Testosterone results in decreased expression of CDKN1A mRNA] |
CTD |
PMID:25596134 PMID:26492952 PMID:31324951 |
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NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of CDKN1B mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
decreases expression |
EXP |
Metformin results in decreased expression of CEBPA mRNA |
CTD |
PMID:19022234 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Cers5 |
ceramide synthase 5 |
increases expression |
EXP |
Metformin results in increased expression of CERS5 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 7:130,859,993...130,897,979
Ensembl chr 7:130,859,990...130,897,947
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G |
Cfd |
complement factor D |
decreases expression |
ISO |
Metformin results in decreased expression of CFD mRNA |
CTD |
PMID:17148569 |
|
NCBI chr 7:9,813,148...9,814,871
Ensembl chr 7:9,813,150...9,815,053
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|
G |
Chek1 |
checkpoint kinase 1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CHEK1 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G |
Chek2 |
checkpoint kinase 2 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of CHEK2 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Chuk |
component of inhibitor of nuclear factor kappa B kinase complex |
decreases expression multiple interactions |
ISO |
Metformin results in decreased expression of CHUK mRNA [Metformin co-treated with Pioglitazone] results in decreased expression of CHUK mRNA |
CTD |
PMID:32589349 |
|
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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G |
Cish |
cytokine inducible SH2-containing protein |
decreases expression |
EXP |
Metformin results in decreased expression of CISH mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250
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G |
Ckap2 |
cytoskeleton associated protein 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CKAP2 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr16:69,839,668...69,864,852
Ensembl chr16:69,839,630...69,864,913
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G |
Cldn2 |
claudin 2 |
decreases expression |
ISO |
Metformin results in decreased expression of CLDN2 protein |
CTD |
PMID:37121296 |
|
NCBI chr X:103,459,870...103,473,794
Ensembl chr X:103,459,780...103,474,838
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|
G |
Cldn3 |
claudin 3 |
decreases expression |
EXP |
Metformin results in decreased expression of CLDN3 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr12:21,708,538...21,710,010
Ensembl chr12:21,708,398...21,711,001
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G |
Cmbl |
carboxymethylenebutenolidase homolog |
decreases expression |
EXP |
Metformin results in decreased expression of CMBL mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
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G |
Cnppd1 |
cyclin Pas1/PHO80 domain containing 1 |
decreases expression |
EXP |
Metformin results in decreased expression of CNPPD1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 9:76,633,475...76,640,164
Ensembl chr 9:76,633,477...76,640,188
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G |
Col4a1 |
collagen type IV alpha 1 chain |
multiple interactions |
ISO |
Metformin inhibits the reaction [Folic Acid results in increased expression of COL4A1 mRNA] |
CTD |
PMID:29380373 |
|
NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
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|
G |
Cpt1a |
carnitine palmitoyltransferase 1A |
decreases expression affects expression |
EXP |
Metformin results in decreased expression of CPT1A mRNA Metformin affects the expression of CPT1A mRNA |
CTD |
PMID:19022234 PMID:31324951 |
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NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055
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|
G |
Cptp |
ceramide-1-phosphate transfer protein |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CPTP mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 5:166,474,947...166,479,103
Ensembl chr 5:166,474,966...166,479,017
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|
G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
EXP |
Metformin inhibits the reaction [Methamphetamine results in decreased expression of and results in decreased phosphorylation of CREB1 protein] |
CTD |
PMID:30742852 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
|
|
G |
Creb3l2 |
cAMP responsive element binding protein 3-like 2 |
multiple interactions increases expression |
ISO EXP |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of CREB3L2 mRNA] Metformin results in increased expression of CREB3L2 mRNA |
CTD |
PMID:29095437 PMID:31324951 |
|
NCBI chr 4:65,907,570...66,112,078
Ensembl chr 4:65,907,655...66,023,763
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|
G |
Crebrf |
CREB3 regulatory factor |
decreases expression |
EXP |
Metformin results in decreased expression of CREBRF mRNA |
CTD |
PMID:31324951 |
|
NCBI chr10:16,399,170...16,479,650
Ensembl chr10:16,404,596...16,461,999
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G |
Creld2 |
cysteine-rich with EGF-like domains 2 |
increases expression |
EXP |
Metformin results in increased expression of CRELD2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543
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G |
Crot |
carnitine O-octanoyltransferase |
increases expression |
EXP |
Metformin results in increased expression of CROT mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
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G |
Crp |
C-reactive protein |
decreases expression multiple interactions |
ISO EXP |
Metformin results in decreased expression of CRP protein Metformin inhibits the reaction [Fructose results in increased expression of CRP protein] |
CTD |
PMID:14557435 PMID:25108154 |
|
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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|
G |
Cst3 |
cystatin C |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of CST3 protein] |
CTD |
PMID:30551545 |
|
NCBI chr 3:136,336,923...136,340,796
Ensembl chr 3:136,336,920...136,340,822
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|
G |
Ctdp1 |
CTD phosphatase subunit 1 |
increases expression |
EXP |
Metformin results in increased expression of CTDP1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr18:73,854,277...73,916,232
Ensembl chr18:73,854,282...73,916,457
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|
G |
Ctdsp2 |
CTD small phosphatase 2 |
decreases expression |
EXP |
Metformin results in decreased expression of CTDSP2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 7:62,805,398...62,825,306
Ensembl chr 7:62,805,658...62,825,302
|
|
G |
Cth |
cystathionine gamma-lyase |
decreases expression |
EXP |
Metformin results in decreased expression of CTH mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 2:246,975,888...247,002,234
Ensembl chr 2:246,975,894...247,002,234
|
|
G |
Ctnnb1 |
catenin beta 1 |
decreases expression |
ISO |
Metformin results in decreased expression of CTNNB1 protein |
CTD |
PMID:34432352 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Ctsc |
cathepsin C |
decreases expression |
EXP |
Metformin results in decreased expression of CTSC mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387
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G |
Cttn |
cortactin |
increases expression |
EXP |
Metformin results in increased expression of CTTN mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:199,599,710...199,635,254
Ensembl chr 1:199,599,710...199,635,164
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G |
Cttnbp2nl |
CTTNBP2 N-terminal like |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of CTTNBP2NL mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 2:192,507,963...192,554,548
Ensembl chr 2:192,507,963...192,541,101
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G |
Cxcl1 |
C-X-C motif chemokine ligand 1 |
affects expression multiple interactions |
EXP |
Metformin affects the expression of CXCL1 mRNA Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of CXCL1 protein]] |
CTD |
PMID:31324951 PMID:36547818 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G |
Cxcl13 |
C-X-C motif chemokine ligand 13 |
decreases expression |
EXP |
Metformin results in decreased expression of CXCL13 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933
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G |
Cxcl2 |
C-X-C motif chemokine ligand 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [IL13 protein results in increased expression of CXCL2 mRNA] |
CTD |
PMID:26497364 |
|
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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G |
Cxcl9 |
C-X-C motif chemokine ligand 9 |
decreases expression |
EXP |
Metformin results in decreased expression of CXCL9 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
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G |
Cyba |
cytochrome b-245 alpha chain |
decreases expression multiple interactions |
ISO EXP |
Metformin results in decreased expression of CYBA mRNA Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of CYBA protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of CYBA mRNA] |
CTD |
PMID:15531508 PMID:27634381 |
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NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721
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G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of CYBB protein] Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NOX2 mRNA] |
CTD |
PMID:35085591 PMID:37120126 |
|
NCBI chr X:13,358,101...13,392,570
Ensembl chr X:13,359,430...13,392,586
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G |
Cycs |
cytochrome c, somatic |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [Streptozocin results in increased expression of CYCS mRNA] Metformin inhibits the reaction [Doxorubicin results in increased secretion of CYCS protein] |
CTD |
PMID:35414346 PMID:37453608 |
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NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G |
Cyp11a1 |
cytochrome P450, family 11, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
Metformin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein] |
CTD |
PMID:16760380 |
|
NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
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G |
Cyp17a1 |
cytochrome P450, family 17, subfamily a, polypeptide 1 |
decreases expression affects expression multiple interactions |
ISO EXP |
Metformin results in decreased expression of CYP17A1 mRNA Metformin affects the expression of CYP17A1 mRNA Metformin inhibits the reaction [Letrozole results in increased expression of CYP17A1 mRNA] |
CTD |
PMID:23166782 PMID:31324951 PMID:32298659 |
|
NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
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G |
Cyp19a1 |
cytochrome P450, family 19, subfamily a, polypeptide 1 |
multiple interactions |
EXP |
Metformin inhibits the reaction [FSHB protein results in increased expression of CYP19A1 protein] |
CTD |
PMID:16760380 |
|
NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression decreases expression |
ISO EXP |
Metformin promotes the reaction [Streptozocin results in increased expression of CYP1A1 mRNA] Metformin results in increased expression of CYP1A1 mRNA Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of and results in increased activity of CYP1A1 protein]; Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYP1A1 mRNA]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] Metformin results in decreased expression of CYP1A1 mRNA; Metformin results in decreased expression of CYP1A1 protein |
CTD |
PMID:22342832 PMID:25110054 PMID:25596134 PMID:25697376 |
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NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression decreases expression |
ISO EXP |
Metformin results in increased expression of CYP1A2 mRNA Metformin results in decreased expression of CYP1A2 mRNA |
CTD |
PMID:19022234 PMID:25596134 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions decreases expression |
ISO |
Metformin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 protein] Metformin results in decreased expression of CYP1B1 mRNA; Metformin results in decreased expression of CYP1B1 protein |
CTD |
PMID:25110054 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp27a1 |
cytochrome P450, family 27, subfamily a, polypeptide 1 |
decreases expression multiple interactions |
ISO |
Metformin results in decreased expression of CYP27A1 mRNA [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP27A1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP27A1 protein |
CTD |
PMID:34058177 |
|
NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551
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G |
Cyp27b1 |
cytochrome P450, family 27, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of CYP27B1 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241
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G |
Cyp2b3 |
cytochrome P450, family 2, subfamily b, polypeptide 3 |
increases expression |
ISO |
Metformin results in increased expression of CYP2B10 mRNA |
CTD |
PMID:22342832 |
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NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
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G |
Cyp2c12 |
cytochrome P450, family 2, subfamily c, polypeptide 12 |
increases expression |
EXP |
Metformin results in increased expression of CYP2C12 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:238,699,859...238,757,011
Ensembl chr 1:238,699,854...238,757,019
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
increases expression |
ISO |
Metformin results in increased expression of CYP2E1 mRNA |
CTD |
PMID:22342832 |
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NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression multiple interactions decreases expression |
ISO |
Metformin results in increased expression of CYP3A4 mRNA Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 mRNA]; Metformin inhibits the reaction [Rifampin results in increased expression of CYP3A4 protein] Metformin results in decreased expression of CYP3A4 mRNA |
CTD |
PMID:19022234 PMID:21920351 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp7a1 |
cytochrome P450 family 7 subfamily A member 1 |
multiple interactions affects expression increases expression |
EXP ISO |
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 mRNA]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of CYP7A1 protein] Metformin affects the expression of CYP7A1 mRNA [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP7A1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP7A1 protein Metformin results in increased expression of CYP7A1 protein |
CTD |
PMID:31100278 PMID:31324951 PMID:34058177 |
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NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
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G |
Cyp7b1 |
cytochrome P450 family 7 subfamily B member 1 |
multiple interactions |
ISO |
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP7B1 mRNA |
CTD |
PMID:34058177 |
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NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698
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G |
Cyp8b1 |
cytochrome P450 family 8 subfamily B member 1 |
increases expression multiple interactions decreases expression |
EXP ISO |
Metformin results in increased expression of CYP8B1 mRNA [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of CYP8B1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of CYP8B1 protein Metformin results in decreased expression of CYP8B1 protein |
CTD |
PMID:31324951 PMID:34058177 |
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NCBI chr 8:121,578,123...121,580,093
Ensembl chr 8:121,557,062...121,580,166
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G |
Dapk1 |
death associated protein kinase 1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of DAPK1 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr17:3,930,223...4,090,991
Ensembl chr17:3,930,213...4,090,991
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G |
Dcxr |
dicarbonyl and L-xylulose reductase |
decreases expression |
EXP |
Metformin results in decreased expression of DCXR mRNA |
CTD |
PMID:31324951 |
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NCBI chr10:106,006,404...106,008,293
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G |
Ddhd1 |
DDHD domain containing 1 |
increases expression |
EXP |
Metformin results in increased expression of DDHD1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr15:18,824,389...18,891,036
Ensembl chr15:18,824,394...18,890,952
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G |
Ddi2 |
DNA damage inducible 1 homolog 2 |
decreases expression |
EXP |
Metformin results in decreased expression of DDI2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 5:153,989,591...154,035,342
Ensembl chr 5:153,995,589...154,035,283
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression multiple interactions |
EXP ISO |
Metformin results in increased expression of DDIT3 mRNA Metformin inhibits the reaction [Rotenone results in increased expression of DDIT3 mRNA] Metformin inhibits the reaction [Glucose results in increased expression of DDIT3 protein] Metformin inhibits the reaction [INS protein results in increased expression of DDIT3 protein] |
CTD |
PMID:25596134 PMID:32189544 PMID:34801538 PMID:36764371 |
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NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
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G |
Ddit4 |
DNA-damage-inducible transcript 4 |
decreases expression increases expression multiple interactions |
EXP ISO |
Metformin results in decreased expression of DDIT4 mRNA Metformin results in increased expression of DDIT4 mRNA [Metformin co-treated with Pioglitazone] results in increased expression of DDIT4 mRNA |
CTD |
PMID:25596134 PMID:32589349 |
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NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105
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G |
Ddit4l |
DNA-damage-inducible transcript 4-like |
multiple interactions |
ISO |
[Metformin co-treated with Pioglitazone] results in increased expression of DDIT4L mRNA |
CTD |
PMID:32589349 |
|
NCBI chr 2:226,128,273...226,131,044
Ensembl chr 2:226,128,276...226,131,375
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G |
Ddx17 |
DEAD-box helicase 17 |
increases expression |
EXP |
Metformin results in increased expression of DDX17 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 7:111,091,127...111,109,353
Ensembl chr 7:111,089,445...111,109,193
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G |
Ddx24 |
DEAD-box helicase 24 |
increases expression |
EXP |
Metformin results in increased expression of DDX24 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 6:122,564,767...122,582,032
Ensembl chr 6:122,564,767...122,581,927
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G |
Denr |
density regulated reinitiation and release factor |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DENR mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr12:32,662,512...32,685,283
Ensembl chr12:32,662,516...32,683,843
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G |
Deptor |
DEP domain containing MTOR-interacting protein |
multiple interactions decreases expression |
ISO |
[Metformin co-treated with Pioglitazone] results in decreased expression of DEPTOR mRNA Metformin results in decreased expression of DEPTOR mRNA |
CTD |
PMID:32589349 |
|
NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
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G |
Dffa |
DNA fragmentation factor subunit alpha |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of DFFA mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 5:159,540,715...159,553,639
Ensembl chr 5:159,540,715...159,553,633
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G |
Dgat2 |
diacylglycerol O-acyltransferase 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [INS protein results in increased activity of DGAT2 protein] |
CTD |
PMID:36764371 |
|
NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428
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G |
Dgka |
diacylglycerol kinase, alpha |
increases expression |
EXP |
Metformin results in increased expression of DGKA mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 7:1,148,734...1,175,324
Ensembl chr 7:1,148,735...1,175,110
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G |
Dhx37 |
DEAH-box helicase 37 |
increases expression |
EXP |
Metformin results in increased expression of DHX37 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr12:31,194,782...31,214,890
Ensembl chr12:31,194,859...31,216,802
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G |
Dhx9 |
DExH-box helicase 9 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DHX9 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr13:65,602,322...65,639,098
Ensembl chr13:65,602,323...65,639,069
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G |
Diablo |
diablo, IAP-binding mitochondrial protein |
multiple interactions |
ISO |
Metformin inhibits the reaction [Acetaminophen affects the localization of DIABLO protein] |
CTD |
PMID:27562556 |
|
NCBI chr12:33,055,784...33,070,401
Ensembl chr12:33,055,263...33,070,387
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G |
Dlat |
dihydrolipoamide S-acetyltransferase |
increases expression |
EXP |
Metformin results in increased expression of DLAT mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 8:50,979,151...51,004,435
Ensembl chr 8:50,978,051...51,004,479
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G |
Dlgap5 |
DLG associated protein 5 |
increases expression |
EXP |
Metformin results in increased expression of DLGAP5 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr15:20,633,964...20,664,569
Ensembl chr15:20,633,966...20,664,518
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G |
Dmbt1 |
deleted in malignant brain tumors 1 |
increases expression |
EXP |
Metformin results in increased expression of DMBT1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478
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G |
Dmxl2 |
Dmx-like 2 |
decreases expression |
EXP |
Metformin results in decreased expression of DMXL2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 8:54,741,164...54,884,948
Ensembl chr 8:54,741,160...54,885,161
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G |
Dnajb9 |
DnaJ heat shock protein family (Hsp40) member B9 |
increases expression |
EXP |
Metformin results in increased expression of DNAJB9 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 6:61,270,385...61,276,795
Ensembl chr 6:61,269,913...61,275,063
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G |
Dnm1l |
dynamin 1-like |
multiple interactions |
EXP |
Metformin inhibits the reaction [Glucose results in increased expression of DNM1L protein] |
CTD |
PMID:30144576 |
|
NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482
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G |
Dnmbp |
dynamin binding protein |
decreases expression |
EXP |
Metformin results in decreased expression of DNMBP mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:242,736,189...242,829,431
Ensembl chr 1:242,736,189...242,802,604
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G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions |
EXP |
Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in decreased expression of DNMT1 mRNA]]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in decreased expression of DNMT1 protein]] |
CTD |
PMID:36547818 |
|
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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|
G |
Dpep1 |
dipeptidase 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of DPEP1 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257
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G |
Dpp9 |
dipeptidyl peptidase 9 |
decreases expression |
EXP |
Metformin results in decreased expression of DPP9 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 9:1,011,347...1,046,337
Ensembl chr 9:1,011,351...1,046,541
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|
G |
Dusp1 |
dual specificity phosphatase 1 |
decreases expression |
EXP |
Metformin results in decreased expression of DUSP1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr10:16,680,478...16,683,275
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|
G |
Dusp22 |
dual specificity phosphatase 22 |
decreases expression |
EXP |
Metformin results in decreased expression of DUSP22 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr17:33,780,980...33,831,241
Ensembl chr17:33,780,981...33,831,321
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G |
Dusp4 |
dual specificity phosphatase 4 |
increases expression |
EXP |
Metformin results in increased expression of DUSP4 mRNA |
CTD |
PMID:19664596 |
|
NCBI chr16:57,376,659...57,398,161
Ensembl chr16:57,377,229...57,398,138
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|
G |
Dusp5 |
dual specificity phosphatase 5 |
increases expression |
EXP ISO |
Metformin results in increased expression of DUSP5 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818
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|
G |
E2f4 |
E2F transcription factor 4 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of E2F4 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr19:33,174,396...33,181,806
Ensembl chr19:33,174,410...33,181,806
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G |
Ebi3 |
Epstein-Barr virus induced 3 |
multiple interactions decreases expression |
EXP ISO |
Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of Ebi3 mRNA in peripheral blood] Metformin decreases expression of Ebi3 mRNA in umbilical vein endothelial cells |
RGD |
PMID:31203154 PMID:31203154 |
RGD:213230155, RGD:213230155 |
NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544
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G |
Ech1 |
enoyl-CoA hydratase 1 |
increases expression |
EXP |
Metformin results in increased expression of ECH1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:84,114,494...84,120,788
Ensembl chr 1:84,112,751...84,120,795
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G |
Eci1 |
enoyl-CoA delta isomerase 1 |
increases expression |
EXP |
Metformin results in increased expression of ECI1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr10:13,456,715...13,470,061
Ensembl chr10:13,456,563...13,470,061
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|
G |
Eda2r |
ectodysplasin A2 receptor |
increases expression multiple interactions |
EXP ISO |
Metformin results in increased expression of EDA2R mRNA Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of EDA2R mRNA] |
CTD |
PMID:25596134 PMID:29095437 |
|
NCBI chr X:62,224,763...62,269,333
Ensembl chr X:62,228,229...62,269,268
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|
G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [Fructose results in increased expression of EDN1 protein] Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA] |
CTD |
PMID:25108154 PMID:26497364 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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|
G |
Efna1 |
ephrin A1 |
decreases expression |
EXP |
Metformin results in decreased expression of EFNA1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 2:174,681,676...174,689,061
Ensembl chr 2:174,681,682...174,690,866
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|
G |
Egr1 |
early growth response 1 |
increases expression |
EXP |
Metformin results in increased expression of EGR1 mRNA |
CTD |
PMID:19664596 PMID:31324951 |
|
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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|
G |
Eif1 |
eukaryotic translation initiation factor 1 |
increases expression |
EXP |
Metformin results in increased expression of EIF1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr10:85,246,751...85,248,842
Ensembl chr10:85,246,764...85,427,327
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G |
Eif2ak3 |
eukaryotic translation initiation factor 2 alpha kinase 3 |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of EIF2AK3 protein]; Metformin inhibits the reaction [Glucose results in increased phosphorylation of EIF2AK3 protein] Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2AK3 protein] |
CTD |
PMID:34801538 PMID:36764371 |
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NCBI chr 4:102,805,495...102,866,914
Ensembl chr 4:102,805,510...102,866,911
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G |
Eif2s1 |
eukaryotic translation initiation factor 2 subunit alpha |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [Glucose results in increased phosphorylation of EIF2S1 protein] Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2S1 protein] |
CTD |
PMID:34801538 PMID:36764371 |
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NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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G |
Eif2s2 |
eukaryotic translation initiation factor 2 subunit beta |
increases expression |
EXP |
Metformin results in increased expression of EIF2S2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:143,374,652...143,395,460
Ensembl chr 3:143,373,686...143,395,432
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G |
Eif3c |
eukaryotic translation initiation factor 3, subunit C |
increases expression |
EXP |
Metformin results in increased expression of EIF3C mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:181,134,604...181,152,489
Ensembl chr 1:181,134,604...181,152,493
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G |
Eif4e |
eukaryotic translation initiation factor 4E |
decreases expression multiple interactions |
ISO |
Metformin results in decreased expression of EIF4E mRNA [Metformin co-treated with Pioglitazone] results in decreased expression of EIF4E mRNA |
CTD |
PMID:32589349 |
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NCBI chr 2:227,066,519...227,099,261
Ensembl chr 2:227,066,673...227,098,683
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G |
Eif4ebp1 |
eukaryotic translation initiation factor 4E binding protein 1 |
decreases phosphorylation multiple interactions |
ISO |
Metformin results in decreased phosphorylation of EIF4EBP1 protein Metformin results in decreased phosphorylation of and results in increased expression of EIF4EBP1 protein Metformin decreases phosphorylation of EIF4EBP1 protein in epithelial cell of alveolus of lung |
CTD RGD |
PMID:22108913 PMID:23363784 PMID:23632475 |
RGD:150404268 |
NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
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G |
Elf4 |
E74 like ETS transcription factor 4 |
increases expression |
EXP |
Metformin results in increased expression of ELF4 mRNA |
CTD |
PMID:25596134 |
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NCBI chr X:127,587,401...127,639,063
Ensembl chr X:127,590,650...127,630,200
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G |
Elk4 |
ETS transcription factor ELK4 |
increases expression |
ISO |
Metformin results in increased expression of ELK4 mRNA |
CTD |
PMID:25596134 |
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NCBI chr13:43,451,130...43,475,035
Ensembl chr13:43,435,843...43,475,035
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G |
Elovl6 |
ELOVL fatty acid elongase 6 |
decreases expression affects expression |
ISO EXP |
Metformin results in decreased expression of ELOVL6 protein Metformin affects the expression of ELOVL6 mRNA |
CTD |
PMID:28576465 PMID:31324951 |
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NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186
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G |
Emb |
embigin |
decreases expression |
EXP |
Metformin results in decreased expression of EMB mRNA |
CTD |
PMID:31324951 |
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NCBI chr 2:49,070,509...49,125,042
Ensembl chr 2:49,069,087...49,125,050
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G |
Eno2 |
enolase 2 |
increases expression |
EXP |
Metformin results in increased expression of ENO2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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G |
Entpd7 |
ectonucleoside triphosphate diphosphohydrolase 7 |
increases expression |
EXP |
Metformin results in increased expression of ENTPD7 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:242,559,365...242,601,044
Ensembl chr 1:242,559,365...242,601,447
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G |
Ep400 |
E1A binding protein p400 |
affects expression |
EXP |
Metformin affects the expression of EP400 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:45,891,886...46,002,523
Ensembl chr12:45,891,916...45,998,861
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G |
Eprs1 |
glutamyl-prolyl-tRNA synthetase 1 |
increases expression |
EXP |
Metformin results in increased expression of EPRS1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr13:96,901,548...96,971,966
Ensembl chr13:96,901,575...96,971,966
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G |
Eqtn |
equatorin |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of EQTN mRNA] |
CTD |
PMID:29095437 |
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NCBI chr 5:109,734,495...109,762,048
Ensembl chr 5:109,728,999...109,761,840
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G |
Erbb3 |
erb-b2 receptor tyrosine kinase 3 |
decreases expression |
EXP |
Metformin results in decreased expression of ERBB3 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
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G |
Ern1 |
endoplasmic reticulum to nucleus signaling 1 |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [Glucose results in increased phosphorylation of ERN1 protein] Metformin inhibits the reaction [INS protein results in increased phosphorylation of ERN1 protein] |
CTD |
PMID:34801538 PMID:36764371 |
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NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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G |
Ero1a |
endoplasmic reticulum oxidoreductase 1 alpha |
multiple interactions |
EXP |
Metformin inhibits the reaction [Glucose results in increased expression of ERO1A protein] |
CTD |
PMID:34801538 |
|
NCBI chr15:18,495,037...18,530,440
Ensembl chr15:18,492,945...18,530,478
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G |
Esr1 |
estrogen receptor 1 |
multiple interactions |
ISO EXP |
Metformin binds to and results in decreased activity of ESR1 protein; Metformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]] Metformin inhibits the reaction [Testosterone results in increased expression of ESR1 mRNA] |
CTD |
PMID:22132214 PMID:26492952 PMID:33049310 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
multiple interactions |
EXP |
Metformin inhibits the reaction [Testosterone results in decreased expression of ESR2 mRNA] |
CTD |
PMID:26492952 |
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NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Esrra |
estrogen related receptor, alpha |
multiple interactions decreases expression |
ISO |
Metformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA] Metformin results in decreased expression of ESRRA mRNA |
CTD |
PMID:23166782 |
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NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268
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G |
Faap20 |
FA core complex associated protein 20 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of FAAP20 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr 5:165,808,370...165,815,291
Ensembl chr 5:165,808,657...165,815,333
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G |
Fabp2 |
fatty acid binding protein 2 |
decreases expression |
EXP |
Metformin results in decreased expression of FABP2 mRNA |
CTD |
PMID:19022234 |
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NCBI chr 2:211,040,032...211,044,089
Ensembl chr 2:211,040,032...211,044,089
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G |
Fabp3 |
fatty acid binding protein 3 |
increases expression |
EXP |
Metformin results in increased expression of FABP3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:142,651,962...142,658,707
Ensembl chr 5:142,651,956...142,658,718
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G |
Fabp7 |
fatty acid binding protein 7 |
increases expression |
EXP |
Metformin results in increased expression of FABP7 mRNA |
CTD |
PMID:31324951 |
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NCBI chr20:37,123,193...37,126,725
Ensembl chr20:37,123,193...37,126,880
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G |
Fam149a |
family with sequence similarity 149, member A |
decreases expression |
EXP |
Metformin results in decreased expression of FAM149A mRNA |
CTD |
PMID:31324951 |
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NCBI chr16:46,855,377...46,914,553
Ensembl chr16:46,854,635...46,912,066
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G |
Fam210a |
family with sequence similarity 210, member A |
increases expression |
EXP |
Metformin results in increased expression of FAM210A mRNA |
CTD |
PMID:25596134 |
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NCBI chr18:61,846,447...61,886,123
Ensembl chr18:61,852,907...61,886,171
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G |
Fam32a |
family with sequence similarity 32, member A |
decreases expression |
EXP |
Metformin results in decreased expression of FAM32A mRNA |
CTD |
PMID:25596134 |
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NCBI chr16:17,603,054...17,607,376
Ensembl chr16:17,603,946...17,607,398
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G |
Fas |
Fas cell surface death receptor |
affects expression |
EXP |
Metformin affects the expression of FAS mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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G |
Fasn |
fatty acid synthase |
decreases expression multiple interactions increases expression |
ISO EXP |
Metformin results in decreased expression of FASN mRNA [Metformin co-treated with caffeic acid] results in decreased expression of FASN protein; Metformin inhibits the reaction [[cyhalothrin co-treated with Oleic Acid] results in increased expression of FASN protein]; Metformin inhibits the reaction [INS protein results in increased expression of FASN protein] Metformin results in increased expression of FASN mRNA |
CTD |
PMID:20956498 PMID:21870829 PMID:28576465 PMID:31324951 PMID:36529352 PMID:36764371 More...
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NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fbp1 |
fructose-bisphosphatase 1 |
decreases expression |
EXP |
Metformin results in decreased expression of FBP1 mRNA |
CTD |
PMID:19022234 |
|
NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071
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G |
Fbxo22 |
F-box protein 22 |
increases expression |
EXP |
Metformin results in increased expression of FBXO22 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 8:55,579,906...55,595,981
Ensembl chr 8:55,579,891...55,596,148
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G |
Fbxo30 |
F-box protein 30 |
increases expression |
EXP |
Metformin results in increased expression of FBXO30 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:5,655,341...5,671,558
Ensembl chr 1:5,655,339...5,672,441
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G |
Fbxo32 |
F-box protein 32 |
decreases expression |
EXP |
Metformin results in decreased expression of FBXO32 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:89,731,428...89,764,997
Ensembl chr 7:89,730,232...89,765,436
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G |
Fech |
ferrochelatase |
decreases expression |
EXP |
Metformin results in decreased expression of FECH mRNA |
CTD |
PMID:25596134 |
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NCBI chr18:57,945,123...57,978,327
Ensembl chr18:57,945,122...57,979,348
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G |
Fgf1 |
fibroblast growth factor 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA] |
CTD |
PMID:26497364 |
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NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
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G |
Fgf19 |
fibroblast growth factor 19 |
multiple interactions |
ISO |
[Ethinyl Estradiol co-treated with Metformin] results in decreased expression of FGF15 mRNA |
CTD |
PMID:34058177 |
|
NCBI chr 1:200,056,526...200,060,980
Ensembl chr 1:200,056,644...200,060,287
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G |
Fgf21 |
fibroblast growth factor 21 |
multiple interactions |
ISO |
Metformin inhibits the reaction [INS protein results in decreased expression of FGF21 protein] |
CTD |
PMID:36764371 |
|
NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
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G |
Fgf6 |
fibroblast growth factor 6 |
affects expression |
EXP |
Metformin affects the expression of MT1F mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 4:159,854,913...159,863,447
Ensembl chr 4:159,854,913...159,863,447
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G |
Fgr |
FGR proto-oncogene, Src family tyrosine kinase |
decreases expression |
EXP |
Metformin results in decreased expression of FGR mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
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G |
Ficd |
FIC domain protein adenylyltransferase |
increases expression |
EXP |
Metformin results in increased expression of FICD mRNA |
CTD |
PMID:31324951 |
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NCBI chr12:42,889,195...42,894,090
Ensembl chr12:42,889,194...42,894,070
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G |
Fis1 |
fission, mitochondrial 1 |
multiple interactions |
EXP |
Metformin inhibits the reaction [Glucose results in increased expression of FIS1 protein] |
CTD |
PMID:30144576 |
|
NCBI chr12:19,708,560...19,723,392
Ensembl chr12:19,708,558...19,723,377
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G |
Fkbp1a |
FKBP prolyl isomerase 1A |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of FKBP1A mRNA |
CTD |
PMID:29309887 |
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NCBI chr 3:140,040,359...140,060,107
Ensembl chr 3:140,040,278...140,060,743
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G |
Flvcr2 |
FLVCR choline and putative heme transporter 2 |
increases expression |
EXP |
Metformin results in increased expression of FLVCR2 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
|
NCBI chr 6:105,408,355...105,472,355
Ensembl chr 6:105,408,339...105,472,353
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G |
Fmo3 |
flavin containing dimethylaniline monoxygenase 3 |
decreases expression |
EXP |
Metformin results in decreased expression of FMO3 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr13:75,309,367...75,334,915
Ensembl chr13:75,309,374...75,328,028
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G |
Fn1 |
fibronectin 1 |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [Dietary Fats results in increased expression of FN1 protein] Metformin inhibits the reaction [Folic Acid results in increased expression of FN1 mRNA]; Metformin inhibits the reaction [Folic Acid results in increased expression of FN1 protein] |
CTD |
PMID:27551045 PMID:29380373 |
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NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678
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G |
Fndc5 |
fibronectin type III domain containing 5 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Dietary Fats results in decreased expression of FNDC5 mRNA]; Metformin inhibits the reaction [Dietary Fats results in decreased expression of FNDC5 protein] |
CTD |
PMID:36375515 |
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NCBI chr 5:141,481,593...141,491,257
Ensembl chr 5:141,481,590...141,490,731
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions decreases expression |
ISO EXP |
Metformin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of FOS protein] Metformin results in decreased expression of FOS mRNA |
CTD |
PMID:20590612 PMID:31324951 |
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NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Foxa2 |
forkhead box A2 |
multiple interactions |
ISO |
[Metformin co-treated with Glucose] affects the localization of FOXA2 protein |
CTD |
PMID:16489446 |
|
NCBI chr 3:135,470,123...135,474,326
Ensembl chr 3:135,470,131...135,474,326
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G |
Foxo1 |
forkhead box O1 |
decreases expression multiple interactions |
ISO EXP |
Metformin results in decreased expression of FOXO1 mRNA Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] affects the localization of FOXO1 protein] |
CTD |
PMID:24428821 PMID:27270450 |
|
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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G |
Foxo3 |
forkhead box O3 |
decreases expression |
EXP |
Metformin results in decreased expression of FOXO3 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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G |
Fshb |
follicle stimulating hormone subunit beta |
multiple interactions |
EXP |
Metformin inhibits the reaction [FSHB protein results in increased expression of CCND2 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CCNE1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of CYP19A1 protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]; Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]; Metformin inhibits the reaction [FSHB protein results in increased secretion of Estradiol]; Metformin inhibits the reaction [FSHB protein results in increased secretion of Progesterone]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSHB protein results in increased phosphorylation of PRKAA1 protein]] |
CTD |
PMID:16760380 |
|
NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370
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G |
Fut4 |
fucosyltransferase 4 |
increases expression |
ISO |
Metformin results in increased expression of FUT4 protein |
CTD |
PMID:26036281 |
|
NCBI chr 8:11,586,721...11,590,682
Ensembl chr 8:11,586,721...11,590,682
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G |
G0s2 |
G0/G1switch 2 |
increases expression |
EXP |
Metformin results in increased expression of G0S2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451
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G |
G6pc1 |
glucose-6-phosphatase catalytic subunit 1 |
multiple interactions decreases expression |
EXP ISO |
Metformin inhibits the reaction [Glucose results in increased expression of G6PC1 mRNA] Metformin results in decreased expression of G6PC1 mRNA Metformin inhibits the reaction [INS protein results in increased expression of G6PC1 protein] |
CTD |
PMID:19576170 PMID:19664596 PMID:24428821 PMID:31324951 PMID:31974165 PMID:33651899 More...
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NCBI chr10:86,307,400...86,318,766
Ensembl chr10:86,257,668...86,333,804
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G |
G6pd |
glucose-6-phosphate dehydrogenase |
increases expression |
EXP |
Metformin results in increased expression of G6PD mRNA |
CTD |
PMID:31324951 |
|
NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801
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G |
Gad1 |
glutamate decarboxylase 1 |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of GAD1 protein] |
CTD |
PMID:35085591 |
|
NCBI chr 3:55,369,704...55,410,335
Ensembl chr 3:55,369,704...55,410,333
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G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
increases expression |
ISO EXP |
Metformin results in increased expression of GADD45A mRNA |
CTD |
PMID:19022234 PMID:25596134 |
|
NCBI chr 4:96,154,789...96,157,091
Ensembl chr 4:96,154,789...96,157,115
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G |
Gars1 |
glycyl-tRNA synthetase 1 |
increases expression |
EXP |
Metformin results in increased expression of GARS1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:84,171,596...84,212,609
Ensembl chr 4:84,171,596...84,212,609
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G |
Gbe1 |
1,4-alpha-glucan branching enzyme 1 |
increases expression |
EXP |
Metformin results in increased expression of GBE1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr11:8,734,806...9,000,226
Ensembl chr11:8,734,820...9,000,210
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G |
Gbp1 |
guanylate binding protein 1 |
decreases expression |
EXP |
Metformin results in decreased expression of GBP1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
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G |
Gbp1-ps1 |
guanylate binding protein 1, pseudogene 1 |
decreases expression |
EXP |
Metformin results in decreased expression of GBP1-PS1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 2:231,517,485...231,525,865
Ensembl chr 2:231,517,398...231,529,600
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G |
Gcg |
glucagon |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of GCG protein]; Metformin inhibits the reaction [GCG results in increased abundance of Glucose] [Metformin co-treated with GCG] results in increased expression of IL1RN mRNA; Metformin inhibits the reaction [GCG protein results in increased expression of ESRRA mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]; Metformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA] |
CTD |
PMID:19002567 PMID:22117073 PMID:23166782 PMID:27270450 |
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NCBI chr 3:47,113,914...47,122,958
Ensembl chr 3:47,113,914...47,122,929
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G |
Gck |
glucokinase |
affects expression multiple interactions |
EXP ISO |
Metformin affects the expression of GCK mRNA Metformin inhibits the reaction [Glucose results in decreased expression of GCK mRNA] Metformin inhibits the reaction [INS protein results in decreased activity of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GCK protein] |
CTD |
PMID:31324951 PMID:31974165 PMID:33651899 |
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NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995
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G |
Gckr |
glucokinase regulator |
multiple interactions |
ISO |
Metformin inhibits the reaction [INS protein results in increased expression of GCKR protein] |
CTD |
PMID:33651899 |
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NCBI chr 6:25,044,592...25,075,834
Ensembl chr 6:25,045,100...25,075,654
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
increases expression |
EXP |
Metformin results in increased expression of GCLC mRNA |
CTD |
PMID:25596134 |
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NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gclm |
glutamate cysteine ligase, modifier subunit |
decreases expression increases expression |
EXP ISO |
Metformin results in decreased expression of GCLM mRNA Metformin results in increased expression of GCLM mRNA |
CTD |
PMID:25596134 PMID:33838154 |
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NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535
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G |
Gcnt3 |
glucosaminyl (N-acetyl) transferase 3, mucin type |
increases expression multiple interactions |
ISO EXP |
Metformin results in increased expression of GCNT3 mRNA Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of GCNT3 mRNA] |
CTD |
PMID:25596134 PMID:29095437 |
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NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562
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G |
Gdf15 |
growth differentiation factor 15 |
increases expression |
EXP |
Metformin results in increased expression of GDF15 mRNA |
CTD |
PMID:25596134 |
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NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions |
ISO |
Metformin inhibits the reaction [Olanzapine results in increased expression of GFAP mRNA] |
CTD |
PMID:32652086 |
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NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Ghrl |
ghrelin and obestatin prepropeptide |
multiple interactions |
ISO |
Metformin inhibits the reaction [Olanzapine results in increased expression of GHRL protein] |
CTD |
PMID:32652086 |
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NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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G |
Ghsr |
growth hormone secretagogue receptor |
multiple interactions |
ISO |
Metformin inhibits the reaction [Olanzapine results in increased expression of GHSR mRNA] |
CTD |
PMID:32652086 |
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NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
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G |
Gimd1 |
GIMAP family P-loop NTPase domain containing 1 |
increases expression |
EXP |
Metformin results in increased expression of GIMD1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 2:221,103,878...221,138,559
Ensembl chr 2:221,103,878...221,138,553
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G |
Gls |
glutaminase |
decreases expression |
ISO |
Metformin results in decreased expression of GLS protein |
CTD |
PMID:28576465 |
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NCBI chr 9:49,344,616...49,416,900
Ensembl chr 9:49,344,781...49,416,900
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G |
Gmppb |
GDP-mannose pyrophosphorylase B |
increases expression |
EXP |
Metformin results in increased expression of GMPPB mRNA |
CTD |
PMID:31324951 |
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NCBI chr 8:108,737,429...108,740,437
Ensembl chr 8:108,693,060...108,767,286
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G |
Gmpr |
guanosine monophosphate reductase |
decreases expression |
ISO |
Metformin results in decreased expression of GMPR mRNA |
CTD |
PMID:23457588 |
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NCBI chr17:19,151,820...19,189,626
Ensembl chr17:19,151,815...19,189,621
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G |
Gnmt |
glycine N-methyltransferase |
decreases expression |
EXP |
Metformin results in decreased expression of GNMT mRNA |
CTD |
PMID:31324951 |
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NCBI chr 9:14,254,675...14,258,028
Ensembl chr 9:14,254,675...14,258,434
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G |
Golph3l |
golgi phosphoprotein 3-like |
increases expression |
EXP |
Metformin results in increased expression of GOLPH3L mRNA |
CTD |
PMID:31324951 |
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NCBI chr 2:183,151,941...183,183,094
Ensembl chr 2:183,153,301...183,183,083
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G |
Golph3l-ps1 |
golgi phosphoprotein 3-like, pseudogene 1 |
increases expression |
EXP |
Metformin results in increased expression of GOLPH3L-PS1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 9:45,890,492...45,891,363
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G |
Got1 |
glutamic-oxaloacetic transaminase 1 |
decreases expression |
EXP |
Metformin results in decreased expression of GOT1 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
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NCBI chr 1:242,357,293...242,381,535
Ensembl chr 1:242,357,306...242,380,633
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G |
Gpam |
glycerol-3-phosphate acyltransferase, mitochondrial |
increases expression |
EXP |
Metformin results in increased expression of GPAM mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639
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G |
Gpat3 |
glycerol-3-phosphate acyltransferase 3 |
increases expression |
ISO |
Metformin results in increased expression of GPAT3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr14:8,715,367...8,768,051
Ensembl chr14:8,714,373...8,766,490
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G |
Gpd1l2 |
glycerol-3-phosphate dehydrogenase 1 like 2 |
increases expression |
EXP |
Metformin results in increased expression of GPD1L2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:91,940,258...91,942,125
Ensembl chr 7:91,940,260...91,942,559
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G |
Gphn |
gephyrin |
increases expression |
EXP |
Metformin results in increased expression of GPHN mRNA |
CTD |
PMID:25596134 |
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NCBI chr 6:96,954,365...97,483,617
Ensembl chr 6:96,892,148...97,483,612
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G |
Gpihbp1 |
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 |
increases expression |
EXP |
Metformin results in increased expression of GPIHBP1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:107,285,584...107,288,702
Ensembl chr 7:107,285,654...107,288,702
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G |
Gpnmb |
glycoprotein nmb |
increases expression |
EXP |
Metformin results in increased expression of GPNMB mRNA |
CTD |
PMID:25596134 |
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NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
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G |
Gpr22 |
G protein-coupled receptor 22 |
decreases expression |
EXP |
Metformin results in decreased expression of GPR22 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 6:48,309,619...48,317,864
Ensembl chr 6:48,310,505...48,317,486
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G |
Gprin3 |
GPRIN family member 3 |
increases expression |
EXP |
Metformin results in increased expression of GPRIN3 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 4:88,572,062...88,657,369
Ensembl chr 4:88,563,607...88,657,429
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO EXP |
Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in increased expression of GPT protein]; Metformin inhibits the reaction [Acetaminophen results in increased expression of and results in increased secretion of and results in increased activity of GPT protein]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased activity of GPT protein] |
CTD |
PMID:24717679 PMID:27562556 PMID:29614383 PMID:31743741 |
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NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Gsk3a |
glycogen synthase kinase 3 alpha |
increases phosphorylation |
ISO |
Metformin results in increased phosphorylation of GSK3A protein |
CTD |
PMID:26835874 |
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NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
increases phosphorylation multiple interactions decreases expression |
ISO EXP |
Metformin results in increased phosphorylation of GSK3B protein AKT1 protein modified form inhibits the reaction [Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein]]; Metformin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in increased expression of GSK3B protein]; Metformin promotes the reaction [plantamajoside results in decreased phosphorylation of GSK3B protein] Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [Methamphetamine results in increased expression of and results in increased phosphorylation of GSK3B protein] Metformin results in decreased expression of GSK3B protein modified form |
CTD |
PMID:21054339 PMID:26835874 PMID:30742852 PMID:30928401 PMID:31877369 PMID:33651899 PMID:33838154 PMID:34432352 PMID:35350904 More...
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NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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G |
Gsn |
gelsolin |
increases expression |
ISO |
Metformin results in increased expression of GSN mRNA |
CTD |
PMID:19022234 |
|
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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G |
Gspt1 |
G1 to S phase transition 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of GSPT1 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr10:4,362,528...4,397,215
Ensembl chr10:4,362,510...4,397,198
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions affects expression |
ISO EXP |
Metformin inhibits the reaction [Carbon Tetrachloride results in decreased activity of GSR protein] Metformin affects the expression of GSR mRNA Metformin inhibits the reaction [Methamphetamine results in decreased activity of GSR protein]; Metformin inhibits the reaction [Streptozocin results in decreased activity of GSR protein] |
CTD |
PMID:24717679 PMID:25596134 PMID:30742852 PMID:35414346 |
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NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Gsta1 |
glutathione S-transferase alpha 1 |
multiple interactions |
EXP |
Metformin inhibits the reaction [Doxorubicin results in increased expression of GSTA1 mRNA] |
CTD |
PMID:22666520 |
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NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121
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G |
Gstm2 |
glutathione S-transferase mu 2 |
decreases expression |
EXP |
Metformin results in decreased expression of GSTM2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961
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G |
Gstp1 |
glutathione S-transferase pi 1 |
increases expression |
EXP |
Metformin results in increased expression of GSTP1 mRNA |
CTD |
PMID:19022234 |
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NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226
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G |
Gypa |
glycophorin A |
decreases expression |
EXP |
Metformin results in decreased expression of GYPA mRNA |
CTD |
PMID:31324951 |
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NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822
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G |
Gys1 |
glycogen synthase 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [INS protein results in decreased expression of GYS1 protein] |
CTD |
PMID:33651899 |
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NCBI chr 1:95,915,443...95,935,292
Ensembl chr 1:95,915,443...95,935,292
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G |
H19 |
H19 imprinted maternally expressed transcript |
increases methylation decreases expression multiple interactions |
ISO EXP |
Metformin increases methylation of H19 RNA in umbilical vein endothelial cells Metformin decreases expression of H19 RNA in umbilical vein endothelial cells Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of H19 RNA in peripheral blood] |
RGD |
PMID:31203154 PMID:31203154 PMID:31203154 |
RGD:213230155, RGD:213230155, RGD:213230155 |
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
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G |
H1f2 |
H1.2 linker histone, cluster member |
decreases expression |
ISO |
Metformin results in decreased expression of H1-2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr17:41,391,106...41,392,597
Ensembl chr17:41,388,477...41,392,635
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G |
H2ax |
H2A.X variant histone |
decreases expression multiple interactions increases expression |
ISO |
Metformin results in decreased expression of H2AX protein [epothilone A co-treated with Metformin] results in increased expression of H2AX mRNA Metformin results in increased expression of H2AX mRNA |
CTD |
PMID:23363784 PMID:29117515 |
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NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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G |
Hal |
histidine ammonia lyase |
decreases expression |
EXP |
Metformin results in decreased expression of HAL mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:28,007,449...28,037,701
Ensembl chr 7:28,006,972...28,037,701
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G |
Hamp |
hepcidin antimicrobial peptide |
decreases expression |
EXP |
Metformin results in decreased expression of HAMP mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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G |
Havcr1 |
hepatitis A virus cellular receptor 1 |
multiple interactions |
EXP |
dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]; Metformin promotes the reaction [dapagliflozin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of HAVCR1 protein]] |
CTD |
PMID:30551545 |
|
NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698
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G |
Hbb |
hemoglobin subunit beta |
decreases expression |
EXP |
Metformin results in decreased expression of HBB-B1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:158,250,421...158,251,832
Ensembl chr 1:158,120,200...158,252,012
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G |
Heatr6 |
HEAT repeat containing 6 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HEATR6 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr10:68,635,048...68,665,445
Ensembl chr10:68,635,065...68,664,105
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G |
Hemgn |
hemogen |
decreases expression |
EXP |
Metformin results in decreased expression of HEMGN mRNA |
CTD |
PMID:31324951 |
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NCBI chr 5:60,679,633...60,698,597
Ensembl chr 5:60,679,633...60,698,669
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G |
Herc3 |
HECT and RLD domain containing E3 ubiquitin protein ligase 3 |
decreases expression |
EXP |
Metformin results in decreased expression of HERC3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:87,952,202...88,042,492
Ensembl chr 4:87,952,274...88,042,488
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G |
Herpud1 |
homocysteine inducible ER protein with ubiquitin like domain 1 |
increases expression |
EXP |
Metformin results in increased expression of HERPUD1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr19:10,598,411...10,609,002
Ensembl chr19:10,598,417...10,618,424
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G |
Hhex |
hematopoietically expressed homeobox |
decreases expression |
EXP |
Metformin results in decreased expression of HHEX mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:235,190,455...235,196,042
Ensembl chr 1:235,190,455...235,196,042
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
affects activity decreases expression multiple interactions |
EXP ISO |
Metformin affects the activity of HIF1A protein Metformin results in decreased expression of HIF1A mRNA [Metformin co-treated with Pioglitazone] results in decreased expression of HIF1A mRNA |
CTD |
PMID:25596134 PMID:32589349 |
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NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hist2h3c2 |
histone cluster 2 H3 family member C2 |
increases expression |
EXP |
Metformin results in increased expression of HIST2H3C2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 2:183,837,296...183,837,721
Ensembl chr 2:183,837,303...183,837,752
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G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
ISO |
[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] results in increased secretion of HMGB1 protein] |
CTD |
PMID:25412314 |
|
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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G |
Hmgcr |
3-hydroxy-3-methylglutaryl-CoA reductase |
decreases expression multiple interactions increases expression |
ISO EXP |
Metformin results in decreased expression of HMGCR mRNA Metformin inhibits the reaction [AGT protein results in increased activity of and results in increased phosphorylation of HMGCR protein] Metformin results in increased expression of HMGCR mRNA |
CTD |
PMID:21870829 PMID:29499335 PMID:31324951 |
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NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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G |
Hmox1 |
heme oxygenase 1 |
increases expression multiple interactions decreases expression decreases response to substance |
ISO EXP |
Metformin results in increased expression of HMOX1 mRNA Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of HMOX1 protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of HMOX1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of HMOX1 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of HMOX1 mRNA] Metformin results in decreased expression of HMOX1 mRNA HMOX1 protein results in decreased susceptibility to Metformin 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Metformin results in decreased expression of HMOX1 protein] Metformin results in decreased expression of HMOX1 mRNA; Metformin results in decreased expression of HMOX1 protein |
CTD |
PMID:19022234 PMID:21457706 PMID:22666520 PMID:23707609 PMID:25596134 PMID:33639173 PMID:33838154 PMID:36999408 More...
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Hnf4a |
hepatocyte nuclear factor 4, alpha |
decreases expression |
EXP ISO |
Metformin results in decreased expression of HNF4A mRNA Metformin results in decreased expression of HNF4A mRNA; Metformin results in decreased expression of HNF4A protein |
CTD |
PMID:19022234 PMID:24428821 |
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NCBI chr 3:152,186,787...152,248,320
Ensembl chr 3:152,186,787...152,248,320
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G |
Hnrnpk |
heterogeneous nuclear ribonucleoprotein K |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of HNRNPK mRNA |
CTD |
PMID:29309887 |
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NCBI chr17:6,262,936...6,275,001
Ensembl chr17:6,262,998...6,274,997
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G |
Hook2 |
hook microtubule-tethering protein 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of HOOK2 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr19:23,151,869...23,170,139
Ensembl chr19:23,151,870...23,164,181
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G |
Hras |
HRas proto-oncogene, GTPase |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of HRAS mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 1:196,290,127...196,299,823
Ensembl chr 1:196,296,263...196,300,615
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G |
Hrh2 |
histamine receptor H 2 |
multiple interactions |
ISO |
[Cimetidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Famotidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin; [Ranitidine binds to and results in decreased activity of HRH2 protein] which affects the susceptibility to Metformin |
CTD |
PMID:16632449 |
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NCBI chr17:10,366,004...10,407,791
Ensembl chr17:10,368,298...10,407,631
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G |
Hsc70-ps1 |
heat shock cognate protein 70, pseudogene 1 |
increases expression |
EXP |
Metformin results in increased expression of HSC70-PS1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 2:164,044,226...164,046,344
Ensembl chr 2:164,044,261...164,046,336
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G |
Hsc70-ps2 |
heat shock cognate protein 70, pseudogene 2 |
increases expression |
EXP |
Metformin results in increased expression of HSC70-PS2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr18:16,210,467...16,212,736
Ensembl chr18:16,210,531...16,212,635
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G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression multiple interactions |
EXP ISO |
Metformin results in increased expression of HSPA5 mRNA Metformin inhibits the reaction [Rotenone results in increased expression of HSPA5 mRNA] Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats co-treated with Fructose] results in increased expression of HSPA5 protein]; Metformin inhibits the reaction [Glucose results in increased expression of HSPA5 protein] Metformin inhibits the reaction [INS protein results in increased expression of HSPA5 protein] |
CTD |
PMID:25596134 PMID:32189544 PMID:34801538 PMID:36764371 |
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NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
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G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
multiple interactions |
ISO |
Metformin inhibits the reaction [INS protein results in decreased expression of HSPA9 protein] |
CTD |
PMID:36764371 |
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NCBI chr18:26,536,131...26,554,294
Ensembl chr18:26,535,798...26,554,292
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G |
Hsph1 |
heat shock protein family H (Hsp110) member 1 |
increases expression |
EXP |
Metformin results in increased expression of HSPH1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr12:5,390,916...5,410,224
Ensembl chr12:5,390,922...5,410,224
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G |
Htatip2 |
HIV-1 Tat interactive protein 2 |
increases expression |
EXP |
Metformin results in increased expression of HTATIP2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:99,473,411...99,488,632
Ensembl chr 1:99,469,245...99,488,629
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G |
Htr1a |
5-hydroxytryptamine receptor 1A |
multiple interactions |
EXP |
Metformin inhibits the reaction [Chlorpyrifos results in increased expression of HTR1A mRNA] |
CTD |
PMID:35448458 |
|
NCBI chr 2:36,693,462...36,698,026
Ensembl chr 2:36,694,174...36,695,442
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G |
Htr2a |
5-hydroxytryptamine receptor 2A |
multiple interactions |
EXP |
Metformin inhibits the reaction [Chlorpyrifos results in increased expression of HTR2A mRNA] |
CTD |
PMID:35448458 |
|
NCBI chr15:49,950,035...50,022,188
Ensembl chr15:49,950,804...50,020,928
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G |
Hykk |
hydroxylysine kinase |
decreases expression |
EXP |
Metformin results in decreased expression of HYKK mRNA |
CTD |
PMID:31324951 |
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NCBI chr 8:55,315,919...55,339,720
Ensembl chr 8:55,315,969...55,337,339
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G |
Hyou1 |
hypoxia up-regulated 1 |
increases expression |
EXP |
Metformin results in increased expression of HYOU1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 8:44,706,073...44,718,189
Ensembl chr 8:44,706,263...44,718,186
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G |
Iars1 |
isoleucyl-tRNA synthetase 1 |
increases expression |
EXP |
Metformin results in increased expression of IARS1 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
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NCBI chr17:14,940,919...14,987,277
Ensembl chr17:14,940,924...14,987,237
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G |
Icam1 |
intercellular adhesion molecule 1 |
multiple interactions |
EXP |
Metformin inhibits the reaction [Fructose results in increased expression of ICAM1 protein modified form] |
CTD |
PMID:25108154 |
|
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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G |
Ide |
insulin degrading enzyme |
multiple interactions |
ISO |
Metformin inhibits the reaction [INS protein results in decreased expression of IDE protein] |
CTD |
PMID:36764371 |
|
NCBI chr 1:235,002,984...235,102,448
Ensembl chr 1:234,995,351...235,102,440
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G |
Idi1 |
isopentenyl-diphosphate delta isomerase 1 |
increases expression |
EXP |
Metformin results in increased expression of IDI1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr17:61,629,592...61,637,357
Ensembl chr17:61,629,594...61,637,357
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G |
Ifgga4l |
interferon-gamma-inducible GTPase 4 like |
decreases expression |
EXP |
Metformin results in decreased expression of IFGGA4L mRNA |
CTD |
PMID:31324951 |
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NCBI chr18:53,838,426...53,854,858
Ensembl chr18:53,851,449...53,852,696
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G |
Ifitm3 |
interferon induced transmembrane protein 3 |
decreases expression |
EXP |
Metformin results in decreased expression of IFITM3 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:196,111,026...196,112,135
Ensembl chr 1:196,111,043...196,112,203
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G |
Ifna1 |
interferon, alpha 1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of IFNA1 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 5:103,097,356...103,097,925
Ensembl chr 5:103,097,356...103,097,925
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G |
Ifng |
interferon gamma |
increases expression multiple interactions |
ISO |
Metformin results in increased expression of IFNG protein [Paclitaxel co-treated with Metformin] results in increased expression of IFNG mRNA |
CTD |
PMID:20869956 PMID:29309887 |
|
NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Igf1 |
insulin-like growth factor 1 |
multiple interactions |
ISO EXP |
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF1 protein] results in increased phosphorylation of AKT1 protein; [Metformin co-treated with Pioglitazone] results in decreased expression of IGF1 mRNA Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IGF1 protein]; Metformin inhibits the reaction [Testosterone results in increased expression of IGF1 mRNA] |
CTD |
PMID:21664031 PMID:23927877 PMID:26492952 PMID:26497364 PMID:32589349 PMID:36999408 More...
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NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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G |
Igf1r |
insulin-like growth factor 1 receptor |
multiple interactions |
ISO EXP |
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNA Metformin inhibits the reaction [Testosterone results in increased expression of IGF1R mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of IGF1R mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of IGF1R protein] |
CTD |
PMID:21664031 PMID:26492952 PMID:36547818 |
|
NCBI chr 1:121,549,831...121,838,548
Ensembl chr 1:121,550,743...121,831,777
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G |
Igf2 |
insulin-like growth factor 2 |
multiple interactions |
ISO |
[Metformin co-treated with IGF2 protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in increased phosphorylation of AKT1 protein |
CTD |
PMID:21664031 |
|
NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018
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G |
Igf2r |
insulin-like growth factor 2 receptor |
multiple interactions increases expression |
ISO EXP |
[Metformin co-treated with IGF1 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF2R mRNA Metformin results in increased expression of IGF2R mRNA |
CTD |
PMID:21664031 PMID:25596134 |
|
NCBI chr 1:47,979,109...48,067,501
Ensembl chr 1:47,979,109...48,067,501
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G |
Igfbp1 |
insulin-like growth factor binding protein 1 |
decreases expression |
ISO EXP |
Metformin results in decreased expression of IGFBP1 mRNA |
CTD |
PMID:21316309 PMID:31324951 |
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NCBI chr14:82,047,415...82,052,482
Ensembl chr14:82,047,415...82,052,482
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of IKBKB mRNA |
CTD |
PMID:29309887 |
|
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il10 |
interleukin 10 |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of IL10 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IL10 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of IL10 protein] |
CTD |
PMID:33639173 PMID:35085591 PMID:37120126 |
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NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
Metformin inhibits the reaction [IL13 protein results in increased expression of ARG1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL24 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCL7 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CCR2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CHIL3 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of CXCL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of EDN1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of FGF1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of IGF1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MGL2 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MMP9 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]; Metformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of RETNLA mRNA] |
CTD |
PMID:26497364 |
|
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il15ra |
interleukin 15 receptor subunit alpha |
multiple interactions decreases expression |
ISO |
[Metformin co-treated with Cyclic AMP] results in decreased expression of IL15RA mRNA; Metformin promotes the reaction [GCG protein results in decreased expression of IL15RA mRNA] Metformin results in decreased expression of IL15RA mRNA |
CTD |
PMID:22117073 |
|
NCBI chr17:66,802,300...66,831,973
Ensembl chr17:66,802,334...66,832,278
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G |
Il17rb |
interleukin 17 receptor B |
decreases expression |
EXP |
Metformin results in decreased expression of IL17RB mRNA |
CTD |
PMID:25596134 |
|
NCBI chr16:5,180,431...5,194,125
Ensembl chr16:5,180,432...5,194,125
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G |
Il1b |
interleukin 1 beta |
multiple interactions increases expression |
ISO EXP |
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK10 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK9 protein]; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; Metformin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] Metformin results in increased expression of IL1B mRNA Metformin inhibits the reaction [IL13 protein results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL1B protein] Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL1B protein]; Metformin inhibits the reaction [Chlorpyrifos results in increased expression of IL1B protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL1B protein]; Metformin inhibits the reaction [Dietary Fats results in increased expression of IL1B protein]; Metformin inhibits the reaction [Methamphetamine results in increased expression of IL1B protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of IL1B protein]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL1B mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of IL1B protein]] |
CTD |
PMID:16385087 PMID:21316309 PMID:26497364 PMID:27551045 PMID:27634381 PMID:28259689 PMID:30742852 PMID:32189544 PMID:33639173 PMID:35085591 PMID:35448458 PMID:36547818 More...
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il1rn |
interleukin 1 receptor antagonist |
multiple interactions increases expression |
ISO |
[Metformin co-treated with GCG] results in increased expression of IL1RN mRNA; Cyclic AMP promotes the reaction [Metformin results in increased expression of IL1RN mRNA]; Metformin promotes the reaction [Cyclic AMP results in increased expression of IL1RN mRNA] |
CTD |
PMID:22117073 |
|
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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G |
Il33 |
interleukin 33 |
decreases expression |
EXP |
Metformin results in decreased expression of IL33 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373
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G |
Il6 |
interleukin 6 |
decreases expression multiple interactions increases expression |
ISO EXP |
Metformin results in decreased expression of IL6 mRNA Metformin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] Metformin results in increased expression of IL6 mRNA; Metformin results in increased expression of IL6 protein 3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 protein]; Metformin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of IL6 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of IL6 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of IL6 protein]; Metformin inhibits the reaction [Fructose results in increased expression of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of IL6 protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL6 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of IL6 protein] Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of Il6 protein in blood serum] |
CTD RGD |
PMID:16385087 PMID:20869956 PMID:20956498 PMID:21457706 PMID:21870829 PMID:24717679 PMID:24842192 PMID:25108154 PMID:27634381 PMID:28096963 PMID:29859833 PMID:32652086 PMID:33639173 PMID:35085591 PMID:31203154 More...
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RGD:213230155 |
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Inmt |
indolethylamine N-methyltransferase |
decreases expression |
EXP |
Metformin results in decreased expression of INMT mRNA |
CTD |
PMID:31324951 |
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NCBI chr 4:84,318,197...84,322,493
Ensembl chr 4:84,318,197...84,322,493
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G |
Ins1 |
insulin 1 |
multiple interactions increases secretion |
EXP ISO |
Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in increased secretion of INS1 protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Coconut Oil co-treated with Cholesterol] results in increased expression of INS1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of INS1 protein]; Metformin inhibits the reaction [Fructose results in increased secretion of INS1 protein]; Metformin inhibits the reaction [Glucose results in increased secretion of INS1 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of INS1 protein] Metformin results in increased secretion of INS1 protein |
CTD |
PMID:22627169 PMID:27634381 PMID:29991592 PMID:30256492 PMID:31877369 PMID:35072544 PMID:35199402 PMID:35414346 More...
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Ins2 |
insulin 2 |
multiple interactions decreases expression increases expression |
ISO |
[Metformin co-treated with INS protein] results in decreased expression of IGF1R mRNA; [Metformin co-treated with INS protein] results in decreased expression of IGF2R mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in increased phosphorylation of AKT1 protein; Metformin inhibits the reaction [[Glucose affects the susceptibility to INS protein] which affects the uptake of Glucose]; Metformin inhibits the reaction [INS protein results in decreased activity of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of ATP6 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of BAD protein]; Metformin inhibits the reaction [INS protein results in decreased expression of FGF21 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GCK protein]; Metformin inhibits the reaction [INS protein results in decreased expression of GYS1 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of HSPA9 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of IDE protein]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS2 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of MFN2 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A2 protein]; Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of AKT1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of GSK3B protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]; Metformin inhibits the reaction [INS protein results in increased activity of DGAT2 protein]; Metformin inhibits the reaction [INS protein results in increased expression of DDIT3 protein]; Metformin inhibits the reaction [INS protein results in increased expression of FASN protein]; Metformin inhibits the reaction [INS protein results in increased expression of G6PC1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of GCKR protein]; Metformin inhibits the reaction [INS protein results in increased expression of GSK3B protein]; Metformin inhibits the reaction [INS protein results in increased expression of HSPA5 protein]; Metformin inhibits the reaction [INS protein results in increased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of ITPR1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of MAPK8 protein]; Metformin inhibits the reaction [INS protein results in increased expression of PPARG protein]; Metformin inhibits the reaction [INS protein results in increased expression of PRKCB protein]; Metformin inhibits the reaction [INS protein results in increased expression of PTPN1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of SCD protein]; Metformin inhibits the reaction [INS protein results in increased expression of SREBF1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of XBP1 protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of ACACA protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2AK3 protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of EIF2S1 protein]; Metformin inhibits the reaction [INS protein results in increased phosphorylation of ERN1 protein]; Metformin promotes the reaction [Glucose results in increased secretion of INS protein]; Metformin results in decreased expression of and results in decreased secretion of INS protein; Metformin results in increased expression of and results in increased secretion of INS protein Metformin results in decreased expression of INS protein Metformin results in increased expression of INS mRNA |
CTD |
PMID:1900072 PMID:15531508 PMID:18082302 PMID:21664031 PMID:21779873 PMID:30914352 PMID:30928401 PMID:33651899 PMID:36764371 More...
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Insig1 |
insulin induced gene 1 |
increases expression |
ISO |
Metformin results in increased expression of INSIG1 mRNA |
CTD |
PMID:23457588 |
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NCBI chr 4:7,315,494...7,323,972
Ensembl chr 4:7,315,495...7,323,952
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G |
Insig2 |
insulin induced gene 2 |
decreases expression |
EXP |
Metformin results in decreased expression of INSIG2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr13:32,472,390...32,500,139
Ensembl chr13:32,473,742...32,494,923
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G |
Insr |
insulin receptor |
multiple interactions increases phosphorylation |
ISO EXP |
[Metformin co-treated with IGF1 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with IGF2 protein] results in decreased expression of INSR mRNA; [Metformin co-treated with INS protein] results in decreased expression of INSR mRNA Metformin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA] Metformin results in increased phosphorylation of INSR protein Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR mRNA]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin co-treated with Ovalbumin] results in decreased expression of INSR protein] |
CTD |
PMID:21664031 PMID:23927877 PMID:26835874 PMID:36547818 |
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NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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G |
Irf2bp2 |
interferon regulatory factor 2 binding protein 2 |
decreases expression |
EXP |
Metformin results in decreased expression of IRF2BP2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr19:54,559,417...54,565,096
Ensembl chr19:54,560,128...54,566,642
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G |
Irf3 |
interferon regulatory factor 3 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of IRF3 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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G |
Irf5 |
interferon regulatory factor 5 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of IRF5 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 4:58,127,577...58,140,665
Ensembl chr 4:58,127,640...58,139,267
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G |
Irf7 |
interferon regulatory factor 7 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of IRF7 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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G |
Irs1 |
insulin receptor substrate 1 |
multiple interactions |
ISO EXP |
Metformin affects the reaction [Testosterone results in decreased expression of IRS1]; Metformin inhibits the reaction [INS protein results in decreased expression of IRS1 protein]; Metformin inhibits the reaction [INS protein results in decreased phosphorylation of IRS1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of IRS1 protein] Metformin inhibits the reaction [Streptozocin results in decreased expression of IRS1 protein]; Metformin promotes the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of IRS1 protein] Metformin inhibits the reaction [Dehydroepiandrosterone results in decreased phosphorylation of IRS1 protein] |
CTD |
PMID:19328476 PMID:23927877 PMID:27634381 PMID:30914352 PMID:30928401 PMID:31743741 PMID:36764371 More...
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NCBI chr 9:83,552,964...83,605,797
Ensembl chr 9:83,548,944...83,606,122
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G |
Irs2 |
insulin receptor substrate 2 |
decreases expression multiple interactions |
EXP ISO |
Metformin results in decreased expression of IRS2 mRNA Metformin inhibits the reaction [INS protein results in decreased expression of IRS2 protein] |
CTD |
PMID:31324951 PMID:36764371 |
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NCBI chr16:78,488,249...78,512,482
Ensembl chr16:78,485,045...78,512,482
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G |
Iscu |
iron-sulfur cluster assembly enzyme |
affects expression |
EXP |
Metformin affects the expression of ISCU mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:42,852,305...42,858,150
Ensembl chr12:42,852,305...42,858,150
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G |
Itgb1 |
integrin subunit beta 1 |
increases expression |
EXP |
Metformin results in increased expression of ITGB1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr19:56,705,123...56,753,199
Ensembl chr19:56,705,171...56,753,195
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G |
Itgb8 |
integrin subunit beta 8 |
increases expression |
EXP |
Metformin results in increased expression of ITGB8 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476
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G |
Itpr1 |
inositol 1,4,5-trisphosphate receptor, type 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [INS protein results in increased expression of ITPR1 protein] |
CTD |
PMID:36764371 |
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NCBI chr 4:141,187,377...141,554,240
Ensembl chr 4:141,187,418...141,510,491
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G |
Itpr2 |
inositol 1,4,5-trisphosphate receptor, type 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ITPR2 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr 4:179,028,594...179,434,657
Ensembl chr 4:179,027,281...179,404,164
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G |
Jkamp |
JNK1/MAPK8-associated membrane protein |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of JKAMP mRNA] |
CTD |
PMID:29095437 |
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NCBI chr 6:90,648,043...90,661,985
Ensembl chr 6:90,648,160...90,662,501
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
Metformin inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of JUN protein] |
CTD |
PMID:20590612 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Junb |
JunB proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
EXP |
Metformin results in decreased expression of JUNB mRNA |
CTD |
PMID:31324951 |
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NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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G |
Jund |
JunD proto-oncogene, AP-1 transcription factor subunit |
increases expression |
ISO |
Metformin results in increased expression of JUND mRNA |
CTD |
PMID:19022234 |
|
NCBI chr16:18,734,121...18,735,799
Ensembl chr16:18,734,122...18,735,799
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G |
Kbtbd12 |
kelch repeat and BTB domain containing 12 |
increases expression |
EXP |
Metformin results in increased expression of KBTBD12 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 4:121,014,636...121,088,701
Ensembl chr 4:121,016,257...121,088,443
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|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
decreases expression multiple interactions |
EXP ISO |
Metformin results in decreased expression of KEAP1 mRNA Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of KEAP1 protein] Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in decreased expression of KEAP1 mRNA] |
CTD |
PMID:25596134 PMID:33639173 PMID:37120126 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
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G |
Klf15 |
KLF transcription factor 15 |
decreases expression |
ISO |
Metformin results in decreased expression of KLF15 mRNA |
CTD |
PMID:24428821 |
|
NCBI chr 4:122,965,718...122,978,403
Ensembl chr 4:122,965,807...122,978,374
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|
G |
Klf9 |
KLF transcription factor 9 |
decreases expression |
EXP |
Metformin results in decreased expression of KLF9 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:220,700,108...220,725,110
Ensembl chr 1:220,700,108...220,725,037
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|
G |
Klhl33 |
kelch-like family member 33 |
decreases expression |
EXP |
Metformin results in decreased expression of KLHL33 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr15:24,105,923...24,114,445
Ensembl chr15:24,105,930...24,114,438
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|
G |
Kras |
KRAS proto-oncogene, GTPase |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of KRAS mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 4:178,185,418...178,218,484
|
|
G |
Krt19 |
keratin 19 |
increases expression |
EXP |
Metformin results in increased expression of KRT19 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr10:85,075,835...85,080,552
Ensembl chr10:85,066,802...85,171,799
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|
G |
Krt80 |
keratin 80 |
increases expression |
ISO |
Metformin results in increased expression of KRT80 mRNA |
CTD |
PMID:21527772 |
|
NCBI chr 7:132,463,216...132,485,134
Ensembl chr 7:132,463,218...132,485,508
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|
G |
Lamc2 |
laminin subunit gamma 2 |
decreases expression |
EXP |
Metformin results in decreased expression of LAMC2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr13:65,284,664...65,344,164
Ensembl chr13:65,284,664...65,344,200
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|
G |
Lars1 |
leucyl-tRNA synthetase 1 |
increases expression |
EXP |
Metformin results in increased expression of LARS1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr18:34,201,555...34,256,003
Ensembl chr18:34,201,549...34,255,931
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|
G |
Lce1d |
late cornified envelope 1D |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of LCE1D mRNA] |
CTD |
PMID:29095437 |
|
|
|
G |
Lcn2 |
lipocalin 2 |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of LCN2 protein] |
CTD |
PMID:30551545 |
|
NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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|
G |
Lcorl |
ligand dependent nuclear receptor corepressor-like |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of LCORL mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr14:65,271,339...65,407,732
Ensembl chr14:65,271,135...65,404,174
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|
G |
Ldha |
lactate dehydrogenase A |
multiple interactions |
ISO |
Metformin inhibits the reaction [Doxorubicin results in increased activity of LDHA protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of LDHA protein] |
CTD |
PMID:37453608 |
|
NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472
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|
G |
Ldlr |
low density lipoprotein receptor |
multiple interactions |
ISO |
Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of LDLR protein] Metformin inhibits the reaction [AGT protein results in increased expression of LDLR protein]; Metformin inhibits the reaction [Hydrogen Peroxide results in increased expression of LDLR protein] |
CTD |
PMID:29499335 |
|
NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
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|
G |
Leap2 |
liver enriched antimicrobial peptide 2 |
increases expression |
EXP |
Metformin results in increased expression of LEAP2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr10:37,580,172...37,581,244
Ensembl chr10:37,577,855...37,581,244
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|
G |
Lep |
leptin |
increases expression multiple interactions |
ISO |
Metformin results in increased expression of LEP protein Metformin inhibits the reaction [Olanzapine results in increased expression of LEP protein] |
CTD |
PMID:20869956 PMID:32652086 |
|
NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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|
G |
Lgals5 |
galectin 5 |
decreases expression |
EXP |
Metformin results in decreased expression of LGALS5 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr10:63,853,949...63,857,198
Ensembl chr10:63,853,935...63,857,153
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G |
Lhb |
luteinizing hormone subunit beta |
multiple interactions |
EXP |
Metformin inhibits the reaction [Letrozole results in increased secretion of LHB protein] |
CTD |
PMID:32298659 |
|
NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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|
G |
Lingo3 |
leucine rich repeat and Ig domain containing 3 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of LINGO3 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 7:8,869,025...8,878,431
Ensembl chr 7:8,869,025...8,878,431
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|
G |
Lmcd1 |
LIM and cysteine-rich domains 1 |
decreases expression |
EXP |
Metformin results in decreased expression of LMCD1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:145,393,153...145,452,049
Ensembl chr 4:145,393,145...145,452,046
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|
G |
Lmna |
lamin A/C |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of LMNA mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 2:173,939,751...173,960,423
Ensembl chr 2:173,939,751...173,960,423
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|
G |
LOC102555377 |
zinc finger protein 182-like |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ZFP982 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 1:62,457,455...62,493,728
Ensembl chr 1:62,457,716...62,493,726
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G |
Lox |
lysyl oxidase |
affects expression |
EXP |
Metformin affects the expression of LOX mRNA |
CTD |
PMID:31324951 |
|
NCBI chr18:45,964,544...45,977,431
Ensembl chr18:45,967,343...46,041,477
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|
G |
Lpar3 |
lysophosphatidic acid receptor 3 |
decreases expression |
EXP |
Metformin results in decreased expression of LPAR3 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 2:235,125,234...235,193,916
Ensembl chr 2:235,149,065...235,193,357
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G |
Lpin2 |
lipin 2 |
decreases expression |
EXP |
Metformin results in decreased expression of LPIN2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 9:111,083,378...111,158,193
Ensembl chr 9:111,083,745...111,158,193
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|
G |
Lss |
lanosterol synthase |
increases expression |
EXP |
Metformin results in increased expression of LSS mRNA |
CTD |
PMID:31324951 |
|
NCBI chr20:12,091,138...12,118,858
Ensembl chr20:12,092,774...12,118,762
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G |
Ltn1 |
listerin E3 ubiquitin protein ligase 1 |
decreases expression |
EXP |
Metformin results in decreased expression of LTN1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr11:26,603,903...26,660,871
Ensembl chr11:26,603,903...26,660,886
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G |
Lurap1l |
leucine rich adaptor protein 1-like |
decreases expression |
EXP |
Metformin results in decreased expression of LURAP1L mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 5:95,362,005...95,409,439
Ensembl chr 5:95,362,005...95,409,438
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G |
Lyst |
lysosomal trafficking regulator |
decreases expression |
EXP |
Metformin results in decreased expression of LYST mRNA |
CTD |
PMID:31324951 |
|
NCBI chr17:86,241,384...86,443,501
Ensembl chr17:86,241,384...86,443,480
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G |
Mad2l1 |
mitotic arrest deficient 2 like 1 |
affects expression |
ISO |
Metformin affects the expression of MAD2L1 mRNA |
CTD |
PMID:35568294 |
|
NCBI chr 4:95,906,692...95,918,885
Ensembl chr 4:95,906,817...95,913,470
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G |
Mafg |
MAF bZIP transcription factor G |
increases expression |
EXP |
Metformin results in increased expression of MAFG mRNA |
CTD |
PMID:25596134 |
|
NCBI chr10:105,903,307...105,911,808
Ensembl chr10:105,903,237...105,912,026
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|
G |
Magohb |
mago homolog B, exon junction complex subunit |
increases expression |
EXP |
Metformin results in increased expression of MAGOHB mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 4:165,034,131...165,041,977
Ensembl chr 4:165,034,122...165,041,967
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G |
Man1a2 |
mannosidase, alpha, class 1A, member 2 |
increases expression |
EXP |
Metformin results in increased expression of MAN1A2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 2:187,947,484...188,096,332
Ensembl chr 2:187,951,617...188,096,332
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G |
Map1lc3b |
microtubule-associated protein 1 light chain 3 beta |
multiple interactions |
ISO |
[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form] |
CTD |
PMID:25412314 |
|
NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
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G |
Map2k3 |
mitogen activated protein kinase kinase 3 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of MAP2K3 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr10:45,608,145...45,629,492
Ensembl chr10:45,607,163...45,629,492
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|
G |
Map3k2 |
mitogen activated protein kinase kinase kinase 2 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K2 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr18:23,807,218...23,879,722
Ensembl chr18:23,807,218...23,871,433
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|
G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
multiple interactions increases activity |
ISO EXP |
[Paclitaxel co-treated with Metformin] results in decreased expression of MAP3K7 mRNA Metformin increases activity of Map3k7 protein in cardiac muscle cells |
CTD RGD |
PMID:29309887 PMID:17085580 |
RGD:155791450 |
NCBI chr 5:46,356,973...46,415,597
Ensembl chr 5:46,357,931...46,415,597
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|
G |
Map4k2 |
mitogen activated protein kinase kinase kinase kinase 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of MAP4K2 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 1:203,645,098...203,660,782
Ensembl chr 1:203,645,153...203,660,331
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO EXP |
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK1 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] Metformin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK1 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein] Metformin results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:16385087 PMID:16760380 PMID:20590612 PMID:23707609 PMID:33639173 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk10 |
mitogen activated protein kinase 10 |
multiple interactions |
ISO |
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK10 protein] |
CTD |
PMID:16385087 |
|
NCBI chr14:6,497,662...6,790,109
Ensembl chr14:6,497,707...6,786,201
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G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of MAPK14 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO EXP |
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK3 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] Metformin inhibits the reaction [Streptozocin results in increased phosphorylation of MAPK3 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein] Metformin results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:16385087 PMID:16760380 PMID:20590612 PMID:23707609 PMID:33639173 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [Glucose results in increased phosphorylation of MAPK8 protein] Metformin inhibits the reaction [INS protein results in increased expression of MAPK8 protein] |
CTD |
PMID:34801538 PMID:36764371 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:16385087 |
|
NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
Metformin results in decreased expression of MCL1 protein |
CTD |
PMID:33838154 |
|
NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
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G |
Mcm10 |
minichromosome maintenance 10 replication initiation factor |
increases expression |
EXP |
Metformin results in increased expression of MCM10 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr17:73,263,788...73,288,346
Ensembl chr17:73,266,095...73,287,364
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G |
Mctp2 |
multiple C2 and transmembrane domain containing 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MCTP2 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 1:125,769,932...126,002,886
Ensembl chr 1:125,771,233...126,002,928
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|
G |
Mdm2 |
MDM2 proto-oncogene |
increases expression |
EXP |
Metformin results in increased expression of MDM2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915
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|
G |
Me1 |
malic enzyme 1 |
increases expression decreases expression |
EXP ISO |
Metformin results in increased expression of ME1 mRNA Metformin results in decreased expression of ME1 protein |
CTD |
PMID:25596134 PMID:28576465 PMID:31324951 |
|
NCBI chr 8:87,549,043...87,660,251
Ensembl chr 8:87,549,043...87,660,304
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|
G |
Med29 |
mediator complex subunit 29 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MED29 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 1:83,677,961...83,683,365
Ensembl chr 1:83,677,961...83,683,365
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|
G |
Mef2a |
myocyte enhancer factor 2a |
increases expression |
ISO |
Metformin results in increased expression of MEF2A mRNA |
CTD |
PMID:15864539 |
|
NCBI chr 1:120,847,874...120,982,488
Ensembl chr 1:120,850,080...120,981,948
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G |
Mef2b |
myocyte enhancer factor 2B |
increases expression |
ISO |
Metformin results in increased expression of MEF2B mRNA |
CTD |
PMID:23457588 |
|
NCBI chr16:19,253,008...19,269,514
Ensembl chr16:19,253,010...19,268,967
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G |
Mef2c |
myocyte enhancer factor 2C |
increases expression |
ISO |
Metformin results in increased expression of MEF2C mRNA |
CTD |
PMID:15864539 |
|
NCBI chr 2:13,973,299...14,136,065
Ensembl chr 2:13,993,438...14,132,880
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|
G |
Mef2d |
myocyte enhancer factor 2D |
increases expression |
ISO |
Metformin results in increased expression of MEF2D mRNA |
CTD |
PMID:15864539 |
|
NCBI chr 2:173,606,054...173,635,620
Ensembl chr 2:173,606,490...173,634,457
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|
G |
Mettl1 |
methyltransferase 1, tRNA methylguanosine |
increases expression |
EXP |
Metformin results in increased expression of METTL1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 7:62,864,860...62,869,202
Ensembl chr 7:62,864,853...62,869,202
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|
G |
Mettl22 |
methyltransferase 22, Kin17 lysine |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of METTL22 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr10:7,113,602...7,130,715
Ensembl chr10:7,113,660...7,130,654
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G |
Mfn2 |
mitofusin 2 |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [Glucose results in decreased expression of MFN2 protein] Metformin inhibits the reaction [INS protein results in decreased expression of MFN2 protein] |
CTD |
PMID:30144576 PMID:36764371 |
|
NCBI chr 5:158,304,285...158,335,502
Ensembl chr 5:158,304,287...158,335,342
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|
G |
Mfsd2a |
MFSD2 lysolipid transporter A, lysophospholipid |
affects expression |
EXP |
Metformin affects the expression of MFSD2A mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 5:135,225,801...135,240,744
Ensembl chr 5:135,225,816...135,240,690
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G |
Mgat2 |
alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase |
increases expression |
EXP |
Metformin results in increased expression of MGAT2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 6:87,656,360...87,658,849
Ensembl chr 6:87,656,349...87,658,177
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|
G |
Mid1ip1 |
MID1 interacting protein 1 |
increases expression |
EXP |
Metformin results in increased expression of MID1IP1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr X:12,060,993...12,063,318
Ensembl chr X:12,060,883...12,065,774
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G |
Mir1 |
microRNA 1 |
increases expression |
EXP |
Metformin results in increased expression of MIR1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr18:1,887,537...1,887,623
|
|
G |
Mir146a |
microRNA 146a |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of MIR146A mRNA] |
CTD |
PMID:30290168 |
|
NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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G |
Mir148a |
microRNA 148a |
increases expression multiple interactions |
ISO EXP |
Metformin increases expression of MIR148A RNA in umbilical vein endothelial cells Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia decreases expression of MIR148A RNA in peripheral blood] |
RGD |
PMID:31203154 PMID:31203154 |
RGD:213230155, RGD:213230155 |
NCBI chr 4:80,333,762...80,333,858
Ensembl chr 4:80,333,762...80,333,858
|
|
G |
Mir152 |
microRNA 152 |
multiple interactions |
EXP |
Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of MIR152 mRNA]] |
CTD |
PMID:36547818 |
|
NCBI chr10:81,832,936...81,833,020
Ensembl chr10:81,832,936...81,833,020
|
|
G |
Mir155 |
microRNA 155 |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in increased expression of MIR155 mRNA] |
CTD |
PMID:30290168 |
|
NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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|
G |
Mir15b |
microRNA 15b |
increases expression |
EXP |
Metformin results in increased expression of MIR15B mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 2:153,245,200...153,245,297
Ensembl chr 2:153,245,200...153,245,297
|
|
G |
Mir190 |
microRNA 190 |
decreases expression |
EXP |
Metformin results in decreased expression of MIR190 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 8:67,850,987...67,851,071
Ensembl chr 8:67,850,987...67,851,071
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|
G |
Mir19a |
microRNA 19a |
multiple interactions |
ISO |
Metformin inhibits the reaction [Oxygen deficiency results in decreased expression of MIR19A mRNA] |
CTD |
PMID:33476677 |
|
NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
|
|
G |
Mir200a |
microRNA 200a |
multiple interactions |
ISO |
Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of MIR200A] |
CTD |
PMID:37120126 |
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NCBI chr 5:166,648,494...166,648,582
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G |
Mir216a |
microRNA 216a |
multiple interactions increases expression |
EXP ISO |
Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia decreases expression of Mir216a RNA in peripheral blood] Metformin increases expression of MIR216A RNA in umbilical vein endothelial cells |
RGD |
PMID:31203154 PMID:31203154 |
RGD:213230155, RGD:213230155 |
NCBI chr14:102,524,105...102,524,210
Ensembl chr14:102,524,105...102,524,210
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G |
Mir29b2 |
microRNA 29b-2 |
decreases expression |
EXP |
Metformin results in decreased expression of MIR29B2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr13:106,570,371...106,570,451
Ensembl chr13:106,570,367...106,570,456
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G |
Mir99b |
microRNA 99b |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary] results in decreased expression of MIR99B mRNA] |
CTD |
PMID:30290168 |
|
NCBI chr 1:58,677,015...58,677,084
Ensembl chr 1:58,677,011...58,677,090
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G |
Mme |
membrane metallo-endopeptidase |
decreases expression |
EXP |
Metformin results in decreased expression of MME mRNA |
CTD |
PMID:31324951 |
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NCBI chr 2:147,686,913...147,803,808
Ensembl chr 2:147,722,086...147,803,792
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G |
Mmp10 |
matrix metallopeptidase 10 |
multiple interactions |
ISO |
Metformin inhibits the reaction [IL13 protein results in increased expression of MMP10 mRNA] |
CTD |
PMID:26497364 |
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NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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G |
Mmp14 |
matrix metallopeptidase 14 |
multiple interactions |
ISO |
Metformin inhibits the reaction [IL13 protein results in increased expression of MMP14 mRNA] |
CTD |
PMID:26497364 |
|
NCBI chr15:27,887,795...27,897,020
Ensembl chr15:27,887,727...27,899,864
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G |
Mmp19 |
matrix metallopeptidase 19 |
increases expression |
EXP |
Metformin results in increased expression of MMP19 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 7:1,221,229...1,229,555
Ensembl chr 7:1,221,343...1,229,555
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions decreases activity decreases expression |
ISO |
Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP2 protein] Metformin results in decreased activity of MMP2 protein Metformin results in decreased expression of MMP2 mRNA |
CTD |
PMID:20590612 PMID:22246099 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions decreases activity decreases expression |
ISO |
Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein] Metformin results in decreased activity of MMP9 protein Metformin results in decreased expression of MMP9 mRNA Metformin inhibits the reaction [IL13 protein results in increased expression of MMP9 mRNA] |
CTD |
PMID:20590612 PMID:22246099 PMID:26497364 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Mocos |
molybdenum cofactor sulfurase |
decreases expression |
EXP |
Metformin results in decreased expression of MOCOS mRNA |
CTD |
PMID:31324951 |
|
NCBI chr18:15,931,659...15,977,415
Ensembl chr18:15,931,654...15,977,187
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G |
Mpo |
myeloperoxidase |
multiple interactions |
ISO |
Metformin inhibits the reaction [Carbon Tetrachloride results in increased activity of MPO protein] |
CTD |
PMID:24717679 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Mrc1 |
mannose receptor, C type 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [IL13 protein results in increased expression of MRC1 protein]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 mRNA]; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MRC1 protein] |
CTD |
PMID:26497364 |
|
NCBI chr17:77,249,187...77,330,857
Ensembl chr17:77,249,187...77,330,857
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G |
Msc |
musculin |
decreases expression |
EXP |
Metformin results in decreased expression of MSC mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 5:4,547,335...4,553,206
Ensembl chr 5:4,547,405...4,553,203
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G |
Msmo1 |
methylsterol monooxygenase 1 |
increases expression |
EXP |
Metformin results in increased expression of MSMO1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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G |
Mt-atp6 |
mitochondrially encoded ATP synthase membrane subunit 6 |
multiple interactions |
ISO |
Metformin inhibits the reaction [INS protein results in decreased expression of ATP6 protein] |
CTD |
PMID:36764371 |
|
NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599 NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599
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G |
Mt-co1 |
mitochondrially encoded cytochrome c oxidase I |
increases expression |
ISO |
Metformin results in increased expression of COX1 protein |
CTD |
PMID:23166782 |
|
NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867 NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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G |
Mt1 |
metallothionein 1 |
affects expression |
EXP |
Metformin affects the expression of MT1A mRNA |
CTD |
PMID:31324951 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049
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G |
Mt1-ps3 |
metallothionein 1, pseudogene 3 |
affects expression |
EXP |
Metformin affects the expression of MT1M mRNA |
CTD |
PMID:31324951 |
|
NCBI chr17:74,786,652...74,787,040
Ensembl chr17:74,786,654...74,787,135
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G |
Mt2A |
metallothionein 2A |
affects expression |
EXP |
Metformin affects the expression of MT2A mRNA |
CTD |
PMID:31324951 |
|
NCBI chr19:10,832,009...10,832,783
Ensembl chr19:10,832,002...10,832,784
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G |
Mtdh |
metadherin |
increases expression |
EXP |
Metformin results in increased expression of MTDH mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 7:65,306,464...65,365,647
Ensembl chr 7:65,306,400...65,364,413
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G |
Mtor |
mechanistic target of rapamycin kinase |
multiple interactions decreases phosphorylation decreases expression |
ISO EXP |
[Metformin co-treated with Pioglitazone] results in decreased expression of MTOR mRNA; Metformin results in decreased phosphorylation of and results in increased expression of MTOR protein Metformin results in decreased phosphorylation of MTOR protein Metformin decreases expression of MTOR protein in epithelial cell of alveolus of lung Metformin results in decreased expression of MTOR protein modified form |
CTD RGD |
PMID:23363784 PMID:27363783 PMID:32589349 PMID:33838154 PMID:23632475 |
RGD:150404268 |
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Mug2 |
murinoglobulin 2 |
decreases expression |
ISO |
Metformin results in decreased expression of MUG2 mRNA |
CTD |
PMID:23457588 |
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NCBI chr 4:155,164,061...155,236,894
Ensembl chr 4:155,164,011...155,236,475
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G |
Mvd |
mevalonate diphosphate decarboxylase |
increases expression |
EXP |
Metformin results in increased expression of MVD mRNA |
CTD |
PMID:31324951 |
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NCBI chr19:50,496,366...50,506,429
Ensembl chr19:50,496,367...50,507,971
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G |
Mx2 |
MX dynamin like GTPase 2 |
increases expression |
EXP |
Metformin results in increased expression of MX2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr11:36,905,698...36,936,308
Ensembl chr11:36,906,111...36,930,342
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G |
Myc |
MYC proto-oncogene, bHLH transcription factor |
increases expression decreases expression multiple interactions |
ISO EXP |
Metformin results in increased expression of MYC mRNA Metformin results in decreased expression of MYC mRNA [Paclitaxel co-treated with Metformin] results in decreased expression of MYC mRNA Metformin results in decreased expression of MYC protein |
CTD |
PMID:19022234 PMID:29226720 PMID:29309887 |
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NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
EXP |
Metformin inhibits the reaction [Isoproterenol results in increased expression of MYD88 mRNA] |
CTD |
PMID:24842192 |
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NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Myh6 |
myosin heavy chain 6 |
multiple interactions |
EXP |
Metformin inhibits the reaction [Doxorubicin results in decreased expression of MYH6 mRNA] |
CTD |
PMID:22666520 |
|
NCBI chr15:28,418,120...28,442,316
Ensembl chr15:28,417,616...28,441,720
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G |
Myh7 |
myosin heavy chain 7 |
multiple interactions |
EXP |
Metformin inhibits the reaction [Doxorubicin results in increased expression of MYH7 mRNA] |
CTD |
PMID:22666520 |
|
NCBI chr15:28,446,550...28,469,888
Ensembl chr15:28,446,550...28,468,217
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G |
Myzap |
myocardial zonula adherens protein |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of MYZAP mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 8:72,155,817...72,243,036
Ensembl chr 8:72,131,530...72,243,036
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G |
Naglu |
N-acetyl-alpha-glucosaminidase |
multiple interactions |
ISO EXP |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of NAGLU mRNA] Metformin inhibits the reaction [Streptozocin results in increased activity of NAGLU protein] |
CTD |
PMID:29095437 PMID:33639173 |
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NCBI chr10:86,001,545...86,009,049
Ensembl chr10:86,001,566...86,008,972
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G |
Nampt |
nicotinamide phosphoribosyltransferase |
affects expression multiple interactions increases expression |
ISO EXP |
Metformin affects the expression of NAMPT mRNA; Metformin affects the expression of NAMPT protein SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA] Metformin results in increased expression of NAMPT mRNA Metformin inhibits the reaction [Letrozole results in increased expression of NAMPT mRNA] |
CTD |
PMID:23315983 PMID:25596134 PMID:32298659 |
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NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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G |
Nars1 |
asparaginyl-tRNA synthetase 1 |
decreases expression increases expression |
EXP |
Metformin results in decreased expression of NARS1 mRNA Metformin results in increased expression of NARS1 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
|
NCBI chr18:57,989,308...58,005,584
Ensembl chr18:57,989,308...58,005,622
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G |
Ncapd2 |
non-SMC condensin I complex, subunit D2 |
increases expression |
EXP |
Metformin results in increased expression of NCAPD2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:157,968,814...157,992,314
Ensembl chr 4:157,968,815...157,992,020
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
decreases expression |
EXP |
Metformin results in decreased expression of NCF1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Nedd9 |
neural precursor cell expressed, developmentally down-regulated 9 |
decreases expression |
EXP |
Metformin results in decreased expression of NEDD9 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr17:23,289,793...23,468,026
Ensembl chr17:23,282,326...23,468,019
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G |
Nfe2l1 |
NFE2 like bZIP transcription factor 1 |
decreases expression increases degradation multiple interactions |
ISO |
Metformin results in decreased expression of NFE2L1 mRNA; Metformin results in decreased expression of NFE2L1 protein Metformin results in increased degradation of NFE2L1 protein Metformin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L1 protein] |
CTD |
PMID:33838154 |
|
NCBI chr10:81,796,055...81,812,926
Ensembl chr10:81,800,366...81,832,318
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
decreases expression multiple interactions affects activity increases activity |
ISO EXP |
Metformin results in decreased expression of NFE2L2 mRNA; Metformin results in decreased expression of NFE2L2 protein Metformin inhibits the reaction [2-tert-butylhydroquinone results in increased stability of and affects the localization of NFE2L2 protein]; Metformin inhibits the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased expression of NFE2L2 protein] Metformin affects the activity of NFE2L2 protein Metformin results in increased activity of NFE2L2 protein Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of NFE2L2 protein]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NFE2L2 protein] Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NFE2L2 protein] |
CTD |
PMID:22627169 PMID:23707609 PMID:25596134 PMID:30114225 PMID:33639173 PMID:33838154 PMID:36999408 PMID:37120126 More...
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NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
multiple interactions |
ISO EXP |
[Paclitaxel co-treated with Metformin] results in decreased expression of NFKB1 mRNA Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of NFKB1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NFKB1 protein] |
CTD |
PMID:29309887 PMID:31100278 PMID:36999408 |
|
NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
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G |
Nfkb2 |
nuclear factor kappa B subunit 2 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of NFKB2 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions decreases expression |
ISO EXP |
Metformin results in decreased phosphorylation of and results in decreased degradation of NFKBIA protein Metformin results in decreased expression of NFKBIA mRNA |
CTD |
PMID:21054339 PMID:31324951 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nin |
ninein |
increases expression |
EXP |
Metformin results in increased expression of NIN mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 6:88,525,405...88,627,710
Ensembl chr 6:88,525,742...88,627,639
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G |
Ninj1 |
ninjurin 1 |
increases expression |
EXP |
Metformin results in increased expression of NINJ1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr17:15,452,804...15,461,684
Ensembl chr17:15,452,813...15,461,704
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G |
Nmur1 |
neuromedin U receptor 1 |
decreases expression |
EXP |
Metformin results in decreased expression of NMUR1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 9:87,033,231...87,038,070
Ensembl chr 9:87,033,279...87,036,684
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G |
Noct |
nocturnin |
affects expression |
EXP |
Metformin affects the expression of NOCT mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 2:135,271,189...135,291,407
Ensembl chr 2:135,271,189...135,291,400
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G |
Nod1 |
nucleotide-binding oligomerization domain containing 1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of NOD1 mRNA |
CTD |
PMID:29309887 |
|
NCBI chr 4:84,060,871...84,111,668
Ensembl chr 4:84,060,880...84,111,404
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G |
Nop58 |
NOP58 ribonucleoprotein |
increases expression |
EXP |
Metformin results in increased expression of NOP58 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 9:61,120,939...61,144,810
Ensembl chr 9:61,120,929...61,144,810
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G |
Nos1 |
nitric oxide synthase 1 |
affects response to substance |
ISO |
NOS1 protein affects the susceptibility to Metformin |
CTD |
PMID:20847317 |
|
NCBI chr12:38,615,111...38,795,492
Ensembl chr12:38,626,714...38,710,945
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G |
Nos2 |
nitric oxide synthase 2 |
increases response to substance increases expression multiple interactions |
ISO EXP |
NOS2 protein results in increased susceptibility to Metformin Metformin results in increased expression of NOS2 protein Metformin inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA]; Metformin inhibits the reaction [Streptozocin results in increased activity of NOS2 protein] |
CTD |
PMID:24770553 PMID:25108154 PMID:33639173 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [Fructose results in decreased phosphorylation of NOS3 protein]; Metformin inhibits the reaction [Palmitic Acid inhibits the reaction [Acetylcholine results in increased phosphorylation of NOS3 protein]] [Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein]] which results in decreased abundance of Nitric Oxide; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of NOS3 protein] |
CTD |
PMID:25108154 PMID:25601987 |
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NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nox4 |
NADPH oxidase 4 |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of NOX4 protein] |
CTD |
PMID:35085591 |
|
NCBI chr 1:140,900,886...141,078,844
Ensembl chr 1:140,901,097...141,077,406
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G |
Nppa |
natriuretic peptide A |
multiple interactions |
EXP |
Metformin inhibits the reaction [Glucose results in increased expression of NPPA protein] |
CTD |
PMID:30144576 |
|
NCBI chr 5:158,429,042...158,430,351
Ensembl chr 5:158,429,042...158,430,351
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G |
Npy |
neuropeptide Y |
multiple interactions |
ISO |
Metformin inhibits the reaction [Olanzapine results in increased expression of NPY mRNA] |
CTD |
PMID:32652086 |
|
NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions decreases expression increases expression |
EXP ISO |
Metformin inhibits the reaction [Doxorubicin results in decreased expression of NQO1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NQO1 mRNA]; Metformin inhibits the reaction [Streptozocin results in decreased expression of NQO1 protein] Metformin results in decreased expression of NQO1 mRNA Metformin results in decreased expression of NQO1 protein Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of and results in increased activity of NQO1 protein]; Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NQO1 mRNA] Metformin results in increased expression of NQO1 mRNA Metformin promotes the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of NQO1 mRNA] |
CTD |
PMID:21457706 PMID:22666520 PMID:23707609 PMID:25596134 PMID:25697376 PMID:33639173 PMID:37120126 More...
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NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr0b2 |
nuclear receptor subfamily 0, group B, member 2 |
decreases expression |
ISO |
Metformin results in decreased expression of NR0B2 mRNA |
CTD |
PMID:24428821 |
|
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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G |
Nr1d1 |
nuclear receptor subfamily 1, group D, member 1 |
increases expression |
EXP |
Metformin results in increased expression of NR1D1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr10:83,728,348...83,735,562
Ensembl chr10:83,728,318...83,735,705
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
decreases expression multiple interactions |
EXP ISO |
Metformin results in decreased expression of NR1I2 mRNA Metformin binds to and results in increased activity of NR1I2 protein; NR1I2 protein affects the susceptibility to [Pregnenolone Carbonitrile co-treated with Metformin] |
CTD |
PMID:19022234 PMID:21920351 PMID:33049310 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Nr1i3 |
nuclear receptor subfamily 1, group I, member 3 |
multiple interactions |
EXP |
Metformin promotes the reaction [Phenobarbital results in increased activity of NR1I3 protein] |
CTD |
PMID:20686344 |
|
NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906
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G |
Nr3c1 |
nuclear receptor subfamily 3, group C, member 1 |
decreases expression |
ISO |
Metformin results in decreased expression of NR3C1 mRNA; Metformin results in decreased expression of NR3C1 protein |
CTD |
PMID:25110054 |
|
NCBI chr18:31,271,681...31,393,320
Ensembl chr18:31,271,681...31,393,375
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G |
Nr4a1 |
nuclear receptor subfamily 4, group A, member 1 |
decreases expression |
EXP |
Metformin results in decreased expression of NR4A1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 7:132,368,399...132,389,300
Ensembl chr 7:132,374,840...132,389,297
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G |
Nr4a2 |
nuclear receptor subfamily 4, group A, member 2 |
decreases expression |
EXP |
Metformin results in decreased expression of NR4A2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
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G |
Nr4a3 |
nuclear receptor subfamily 4, group A, member 3 |
decreases expression |
EXP |
Metformin results in decreased expression of NR4A3 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 5:62,361,588...62,401,489
Ensembl chr 5:62,361,822...62,402,733
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|
G |
Nras |
NRAS proto-oncogene, GTPase |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of NRAS mRNA |
CTD |
PMID:29309887 |
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NCBI chr 2:190,582,885...190,593,509
Ensembl chr 2:190,582,918...190,591,626
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G |
Nrf1 |
nuclear respiratory factor 1 |
increases expression |
ISO |
Metformin results in increased expression of NRF1 mRNA |
CTD |
PMID:16380484 PMID:24428821 |
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NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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G |
Ntpcr |
nucleoside-triphosphatase, cancer-related |
decreases expression |
EXP |
Metformin results in decreased expression of NTPCR mRNA |
CTD |
PMID:25596134 |
|
NCBI chr19:53,701,496...53,715,260
Ensembl chr19:53,695,976...53,715,202
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G |
Ntrk2 |
neurotrophic receptor tyrosine kinase 2 |
multiple interactions |
EXP |
Metformin inhibits the reaction [Streptozocin results in increased expression of NTRK2 mRNA] |
CTD |
PMID:35414346 |
|
NCBI chr17:5,558,992...5,870,299
Ensembl chr17:5,559,043...5,869,136
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G |
Nupr1 |
nuclear protein 1, transcriptional regulator |
increases expression |
EXP |
Metformin results in increased expression of NUPR1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:181,213,292...181,215,327
Ensembl chr 1:181,213,368...181,215,281
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G |
Oat |
ornithine aminotransferase |
decreases expression |
EXP |
Metformin results in decreased expression of OAT mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:187,347,862...187,367,644
Ensembl chr 1:187,347,865...187,367,682
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G |
Oga |
O-GlcNAcase |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of OGA protein] |
CTD |
PMID:30551545 |
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NCBI chr 1:244,598,285...244,633,835
Ensembl chr 1:244,598,292...244,634,359
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G |
Ogg1 |
8-oxoguanine DNA glycosylase |
multiple interactions |
ISO |
Metformin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of OGG1 mRNA] |
CTD |
PMID:25697376 |
|
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
multiple interactions |
EXP |
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of OLR1 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of OLR1 mRNA] |
CTD |
PMID:27634381 |
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NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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G |
Olr906 |
olfactory receptor 906 |
decreases expression |
EXP |
Metformin results in decreased expression of OLR906 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 7:1,821,264...1,822,202
Ensembl chr 7:1,821,264...1,822,202
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G |
Onecut1 |
one cut homeobox 1 |
decreases expression |
EXP |
Metformin results in decreased expression of ONECUT1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 8:75,599,432...75,633,598
Ensembl chr 8:75,599,740...75,627,277
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G |
Opa1 |
OPA1, mitochondrial dynamin like GTPase |
multiple interactions |
EXP |
Metformin inhibits the reaction [Glucose results in decreased expression of OPA1 protein] |
CTD |
PMID:30144576 |
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NCBI chr11:71,108,100...71,185,170
Ensembl chr11:71,109,873...71,185,109
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G |
Orai3 |
ORAI calcium release-activated calcium modulator 3 |
decreases expression |
EXP |
Metformin results in decreased expression of ORAI3 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:182,381,196...182,386,055
Ensembl chr 1:182,344,293...182,386,052
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G |
Osgin1 |
oxidative stress induced growth inhibitor 1 |
decreases expression affects expression |
EXP |
Metformin results in decreased expression of OSGIN1 mRNA Metformin affects the expression of OSGIN1 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
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NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
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G |
Otub2 |
OTU deubiquitinase, ubiquitin aldehyde binding 2 |
increases expression |
EXP |
Metformin results in increased expression of OTUB2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 6:122,545,067...122,563,657
Ensembl chr 6:122,545,061...122,563,644
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G |
Otud1 |
OTU deubiquitinase 1 |
decreases expression |
EXP |
Metformin results in decreased expression of OTUD1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr17:82,259,920...82,262,770
Ensembl chr17:82,259,840...82,262,995
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G |
P2rx7 |
purinergic receptor P2X 7 |
increases expression |
EXP |
Metformin results in increased expression of P2RX7 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619
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G |
P4hb |
prolyl 4-hydroxylase subunit beta |
multiple interactions |
EXP |
Metformin inhibits the reaction [Glucose results in increased expression of P4HB protein] |
CTD |
PMID:34801538 |
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NCBI chr10:105,836,972...105,848,583
Ensembl chr10:105,836,982...105,848,500
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G |
Pank1 |
pantothenate kinase 1 |
decreases expression |
EXP |
Metformin results in decreased expression of PANK1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:232,324,718...232,395,445
Ensembl chr 1:232,328,430...232,396,829
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions increases expression increases cleavage |
EXP ISO |
Metformin inhibits the reaction [Dietary Fats results in increased expression of and results in increased cleavage of PARP1 protein] [epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA; plantamajoside promotes the reaction [Metformin results in increased cleavage of PARP1 protein]; Sodium Salicylate promotes the reaction [Metformin results in increased expression of PARP1 mRNA]; triciribine promotes the reaction [[epothilone A co-treated with Metformin] results in increased expression of PARP1 mRNA] Deoxyglucose promotes the reaction [Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form]]; Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PARP1 protein modified form] |
CTD |
PMID:27551045 PMID:29095437 PMID:29117515 PMID:35350904 |
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NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pck1 |
phosphoenolpyruvate carboxykinase 1 |
multiple interactions decreases expression |
ISO EXP |
Metformin inhibits the reaction [Bucladesine results in increased expression of PCK1 mRNA]; Metformin inhibits the reaction [PPARGC1A protein results in increased expression of PCK1 mRNA] Metformin results in decreased expression of PCK1 mRNA |
CTD |
PMID:22117073 PMID:24428821 PMID:31324951 |
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NCBI chr 3:161,930,256...161,936,205
Ensembl chr 3:161,930,256...161,936,191
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G |
Pde8a |
phosphodiesterase 8A |
decreases expression |
EXP |
Metformin results in decreased expression of PDE8A mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:135,166,143...135,288,986
Ensembl chr 1:135,166,237...135,288,024
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G |
Pdha1 |
pyruvate dehydrogenase E1 subunit alpha 1 |
multiple interactions |
ISO |
Metformin results in decreased phosphorylation of and results in increased activity of PDHA1 protein |
CTD |
PMID:28576465 |
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NCBI chr X:34,700,481...34,714,309
Ensembl chr X:34,700,409...34,714,311
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G |
Pdia5 |
protein disulfide isomerase family A, member 5 |
decreases expression |
EXP |
Metformin results in decreased expression of PDIA5 mRNA |
CTD |
PMID:25596134 |
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NCBI chr11:65,272,152...65,359,087
Ensembl chr11:65,272,155...65,359,084
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G |
Pdk1 |
pyruvate dehydrogenase kinase 1 |
affects expression increases expression |
EXP |
Metformin affects the expression of PDK1 mRNA Metformin results in increased expression of PDK1 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
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NCBI chr 3:56,705,824...56,733,040
Ensembl chr 3:56,705,871...56,733,038
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G |
Pdk4 |
pyruvate dehydrogenase kinase 4 |
decreases expression |
EXP |
Metformin results in decreased expression of PDK4 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:33,591,796...33,601,798
Ensembl chr 4:33,589,799...33,601,850
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G |
Pdlim1 |
PDZ and LIM domain 1 |
increases expression |
EXP |
Metformin results in increased expression of PDLIM1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:239,042,372...239,091,074
Ensembl chr 1:239,042,385...239,091,076
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G |
Pdlim3 |
PDZ and LIM domain 3 |
decreases expression |
EXP |
Metformin results in decreased expression of PDLIM3 mRNA |
CTD |
PMID:31324951 |
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NCBI chr16:46,352,460...46,383,680
Ensembl chr16:46,352,467...46,383,657
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G |
Pdpk1 |
3-phosphoinositide dependent protein kinase-1 |
decreases expression |
ISO |
Metformin results in decreased expression of PDPK1 mRNA |
CTD |
PMID:32589349 |
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NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
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G |
Pdrg1 |
p53 and DNA damage regulated 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PDRG1 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr 3:141,477,561...141,483,730
Ensembl chr 3:141,476,501...141,483,858 Ensembl chr 3:141,476,501...141,483,858
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G |
Pdx1 |
pancreatic and duodenal homeobox 1 |
multiple interactions increases expression |
ISO |
[Metformin co-treated with Glucose] affects the localization of PDX1 protein Metformin results in increased expression of PDX1 protein |
CTD |
PMID:16489446 |
|
NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
decreases expression |
ISO |
Metformin decreases expression of PECAM1 protein in epithelial cell of alveolus of lung |
RGD |
PMID:23632475 |
RGD:150404268 |
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Penk |
proenkephalin |
increases expression |
EXP |
Metformin results in increased expression of PENK mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 5:17,183,799...17,189,160
Ensembl chr 5:17,183,806...17,189,129
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G |
Per1 |
period circadian regulator 1 |
decreases expression |
EXP |
Metformin results in decreased expression of PER1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr10:53,800,126...53,814,963
Ensembl chr10:53,805,535...53,814,431
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G |
Pfkfb1 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 |
increases expression multiple interactions |
EXP ISO |
Metformin results in increased expression of PFKFB1 mRNA PFKFB1 gene mutant form inhibits the reaction [Metformin results in decreased abundance of Glucose-6-Phosphate metabolite]; PFKFB1 gene mutant form inhibits the reaction [Metformin results in increased abundance of Glyceraldehyde 3-Phosphate metabolite] |
CTD |
PMID:31324951 PMID:31974165 |
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NCBI chr X:19,508,522...19,562,165
Ensembl chr X:19,508,546...19,562,182
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G |
Pgm2 |
phosphoglucomutase 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PGM2 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr14:44,166,314...44,199,828
Ensembl chr14:44,164,425...44,199,967
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G |
Phgdh |
phosphoglycerate dehydrogenase |
increases expression |
EXP |
Metformin results in increased expression of PHGDH mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 2:185,906,962...185,936,054
Ensembl chr 2:185,906,966...185,935,944
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G |
Phkg1 |
phosphorylase kinase catalytic subunit gamma 1 |
decreases expression |
EXP |
Metformin results in decreased expression of PHKG1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr12:26,838,822...26,854,547
Ensembl chr12:26,838,968...26,852,850
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G |
Phlda3 |
pleckstrin homology-like domain, family A, member 3 |
increases expression multiple interactions |
EXP ISO |
Metformin results in increased expression of PHLDA3 mRNA Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PHLDA3 mRNA] |
CTD |
PMID:25596134 PMID:29095437 |
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NCBI chr13:47,193,250...47,196,335
Ensembl chr13:47,193,086...47,196,335
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G |
Pias2 |
protein inhibitor of activated STAT, 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of PIAS2 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr18:70,608,034...70,714,295
Ensembl chr18:70,607,665...70,710,033
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G |
Pidd1 |
p53-induced death domain protein 1 |
increases expression |
EXP |
Metformin results in increased expression of PIDD1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:196,536,815...196,542,808
Ensembl chr 1:196,536,834...196,542,699
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G |
Pik3c3 |
phosphatidylinositol 3-kinase, catalytic subunit type 3 |
decreases expression multiple interactions |
ISO |
Metformin results in decreased expression of PIK3C3 mRNA [Metformin co-treated with Pioglitazone] results in decreased expression of PIK3C3 mRNA |
CTD |
PMID:32589349 |
|
NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
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G |
Pik3ca |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
multiple interactions decreases expression |
ISO |
[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CA mRNA Metformin results in decreased expression of PIK3CA mRNA |
CTD |
PMID:32589349 |
|
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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G |
Pik3cb |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta |
multiple interactions |
ISO |
[Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CB mRNA |
CTD |
PMID:32589349 |
|
NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
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G |
Pik3cg |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma |
decreases expression multiple interactions |
ISO |
Metformin results in decreased expression of PIK3CG mRNA [Metformin co-treated with Pioglitazone] results in decreased expression of PIK3CG mRNA |
CTD |
PMID:32589349 |
|
NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
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G |
Pik3r1 |
phosphoinositide-3-kinase regulatory subunit 1 |
increases expression decreases expression multiple interactions |
ISO EXP |
Metformin results in increased expression of PIK3R1 mRNA Metformin results in decreased expression of PIK3R1 mRNA Metformin inhibits the reaction [Olanzapine results in decreased expression of PIK3R1 mRNA] |
CTD |
PMID:21870829 PMID:31324951 PMID:32652086 |
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NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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G |
Pilra |
paired immunoglobin-like type 2 receptor alpha |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PILRA mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr12:17,787,169...17,798,149
Ensembl chr12:17,787,127...17,798,094
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G |
Pir |
pirin |
decreases expression |
EXP |
Metformin results in decreased expression of PIR mRNA |
CTD |
PMID:25596134 |
|
NCBI chr X:30,108,536...30,219,269
Ensembl chr X:30,108,538...30,219,218
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G |
Pklr |
pyruvate kinase L/R |
increases expression multiple interactions |
EXP |
Metformin results in increased expression of PKLR mRNA Metformin inhibits the reaction [Glucose results in increased expression of PKLR mRNA] |
CTD |
PMID:31324951 PMID:31974165 |
|
NCBI chr 2:174,543,008...174,551,863
Ensembl chr 2:174,543,039...174,551,870
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G |
Pla2g12a |
phospholipase A2, group XIIA |
affects expression |
EXP |
Metformin affects the expression of PLA2G12A mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 2:218,436,497...218,452,742
Ensembl chr 2:218,436,513...218,452,740
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G |
Plat |
plasminogen activator, tissue type |
increases activity |
ISO |
Metformin results in increased activity of PLAT protein |
CTD |
PMID:1900072 |
|
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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G |
Pld1 |
phospholipase D1 |
decreases expression multiple interactions |
ISO |
Metformin results in decreased expression of PLD1 mRNA [Metformin co-treated with Pioglitazone] results in decreased expression of PLD1 mRNA |
CTD |
PMID:32589349 |
|
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
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G |
Plekhb1 |
pleckstrin homology domain containing B1 |
increases expression |
EXP |
Metformin results in increased expression of PLEKHB1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:154,998,798...155,013,094
Ensembl chr 1:154,998,800...155,016,142
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G |
Plin2 |
perilipin 2 |
affects expression |
EXP |
Metformin affects the expression of PLIN2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 5:101,156,648...101,211,738
Ensembl chr 5:101,154,411...101,242,319
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G |
Plk2 |
polo-like kinase 2 |
increases expression |
EXP |
Metformin results in increased expression of PLK2 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 2:41,969,176...41,974,945
Ensembl chr 2:41,969,176...41,974,947
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G |
Plppr1 |
phospholipid phosphatase related 1 |
increases expression |
EXP |
Metformin results in increased expression of PLPPR1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 5:63,437,457...63,725,286
Ensembl chr 5:63,437,816...63,763,835
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G |
Pltp |
phospholipid transfer protein |
decreases expression |
EXP |
Metformin results in decreased expression of PLTP mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647
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G |
Pmepa1 |
prostate transmembrane protein, androgen induced 1 |
affects expression |
EXP |
Metformin affects the expression of PMEPA1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 3:162,011,884...162,060,343
Ensembl chr 3:162,012,751...162,060,454
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G |
Pmm2 |
phosphomannomutase 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PMM2 mRNA] |
CTD |
PMID:29095437 |
|
NCBI chr10:6,961,521...6,982,913
Ensembl chr10:6,961,709...6,983,098
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G |
Pnpla3 |
patatin-like phospholipase domain containing 3 |
affects expression |
EXP |
Metformin affects the expression of PNPLA3 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 7:115,293,538...115,314,077
Ensembl chr 7:115,293,538...115,314,077
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G |
Pnpla6 |
patatin-like phospholipase domain containing 6 |
decreases expression |
EXP |
Metformin results in decreased expression of PNPLA6 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr12:1,574,387...1,603,735
Ensembl chr12:1,560,363...1,603,734
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G |
Podxl |
podocalyxin-like |
increases expression |
EXP |
Metformin results in increased expression of PODXL mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 4:60,135,124...60,181,829
Ensembl chr 4:60,135,109...60,181,899
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G |
Polr3f |
RNA polymerase III subunit F |
increases expression |
EXP |
Metformin results in increased expression of POLR3F mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 3:131,908,466...131,924,838
Ensembl chr 3:131,908,466...131,924,837
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G |
Pomc |
proopiomelanocortin |
multiple interactions |
ISO |
Metformin inhibits the reaction [Olanzapine results in decreased expression of POMC mRNA] |
CTD |
PMID:32652086 |
|
NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
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G |
Pon1 |
paraoxonase 1 |
increases response to substance |
ISO |
PON1 gene mutant form results in increased susceptibility to Metformin |
CTD |
PMID:26945512 |
|
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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G |
Pou5f1 |
POU class 5 homeobox 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Estradiol promotes the reaction [ESR1 protein binds to POU5F1 promoter]]; Metformin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [ESR1 protein binds to POU5F1 promoter]] |
CTD |
PMID:22132214 |
|
NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
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G |
Ppan |
peter pan homolog |
increases expression |
EXP |
Metformin results in increased expression of PPAN mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 8:19,423,908...19,427,941
Ensembl chr 8:19,423,961...19,427,938
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions decreases expression increases activity increases expression |
ISO EXP |
[rosiglitazone co-treated with Metformin] results in increased expression of PPARA mRNA; [rosiglitazone co-treated with Metformin] results in increased expression of PPARA protein; Metformin inhibits the reaction [Streptozocin results in decreased expression of PPARA mRNA] Metformin results in decreased expression of PPARA mRNA Metformin results in increased activity of PPARA protein Metformin results in increased expression of PPARA mRNA |
CTD |
PMID:20823565 PMID:22117073 PMID:23166782 PMID:23927877 PMID:29991592 PMID:31324951 More...
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NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
decreases expression increases expression multiple interactions affects activity |
ISO EXP |
Metformin results in decreased expression of PPARG mRNA Metformin results in increased expression of PPARG mRNA Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of PPARG protein]; Metformin inhibits the reaction [Palmitic Acid results in decreased expression of PPARG mRNA] Metformin affects the activity of PPARG protein Metformin inhibits the reaction [IL13 protein results in increased expression of PPARG mRNA] Metformin inhibits the reaction [[cyhalothrin co-treated with Oleic Acid] results in increased expression of PPARG protein]; Metformin inhibits the reaction [INS protein results in increased expression of PPARG protein] |
CTD |
PMID:20724125 PMID:20956498 PMID:21870829 PMID:25108154 PMID:25596134 PMID:26497364 PMID:30256492 PMID:36529352 PMID:36764371 More...
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
multiple interactions increases expression |
ISO |
PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA] Metformin results in increased expression of PPARGC1A mRNA; Metformin results in increased expression of PPARGC1A protein dorsomorphin inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [Bucladesine results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [GCG protein results in increased expression of PPARGC1A mRNA]; Metformin inhibits the reaction [Glucose results in decreased expression of PPARGC1A protein]; Metformin inhibits the reaction [PPARGC1A protein results in decreased expression of TNFSF12 mRNA]; Metformin inhibits the reaction [PPARGC1A protein results in increased expression of PCK1 mRNA]; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; PRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; SIRT1 mutant form inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA] |
CTD |
PMID:15864539 PMID:16380484 PMID:22117073 PMID:23090186 PMID:24428821 PMID:34302933 More...
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NCBI chr14:58,860,752...59,516,525
Ensembl chr14:58,861,144...59,512,656
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G |
Ppfibp1 |
PPFIA binding protein 1 |
increases expression |
EXP |
Metformin results in increased expression of PPFIBP1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 4:179,807,579...179,951,428
Ensembl chr 4:179,808,794...179,951,428
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G |
Ppm1d |
protein phosphatase, Mg2+/Mn2+ dependent, 1D |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of PPM1D mRNA] |
CTD |
PMID:29095437 |
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NCBI chr10:70,172,603...70,208,607
Ensembl chr10:70,172,603...70,208,607
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G |
Ppm1k |
protein phosphatase, Mg2+/Mn2+ dependent, 1K |
decreases expression |
EXP |
Metformin results in decreased expression of PPM1K mRNA |
CTD |
PMID:31324951 |
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NCBI chr 4:87,612,198...87,638,993
Ensembl chr 4:87,612,204...87,636,152
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G |
Ppp1r15a |
protein phosphatase 1, regulatory subunit 15A |
increases expression |
EXP ISO |
Metformin results in increased expression of PPP1R15A mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:96,000,053...96,003,128
Ensembl chr 1:96,000,058...96,003,171
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G |
Ppp1r3c |
protein phosphatase 1, regulatory subunit 3C |
increases expression |
EXP |
Metformin results in increased expression of PPP1R3C mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:234,460,958...234,465,961
Ensembl chr 1:234,460,652...234,465,961
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G |
Ppp4r2 |
protein phosphatase 4, regulatory subunit 2 |
decreases expression |
EXP |
Metformin results in decreased expression of PPP4R2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 4:133,454,555...133,495,486
Ensembl chr 4:133,454,555...133,495,486
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G |
Prc1 |
protein regulator of cytokinesis 1 |
increases expression |
EXP |
Metformin results in increased expression of PRC1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:134,250,086...134,271,765
Ensembl chr 1:134,250,081...134,271,765
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G |
Prdm1 |
PR/SET domain 1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of PRDM1 mRNA |
CTD |
PMID:29309887 |
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NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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G |
Prdx2 |
peroxiredoxin 2 |
decreases expression |
ISO |
Metformin results in decreased expression of PRDX2 mRNA |
CTD |
PMID:23457588 |
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NCBI chr19:23,180,927...23,186,217
Ensembl chr19:23,180,930...23,186,194
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G |
Prkaa1 |
protein kinase AMP-activated catalytic subunit alpha 1 |
multiple interactions increases phosphorylation affects response to substance |
ISO EXP |
Metformin inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased phosphorylation of PRKAA1 protein]; Metformin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; Orotic Acid inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein]; PRKAA1 protein affects the reaction [Metformin inhibits the reaction [Glucose deficiency results in increased chemical synthesis of Reactive Oxygen Species]]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of ABCB1 protein]; PRKAA1 protein affects the reaction [Metformin results in decreased expression of RELA protein]; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA]; PRKAA1 protein affects the reaction [Metformin results in increased expression of SOD2 mRNA] [[PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin] which results in increased abundance of Glucose-6-Phosphate; [PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA] 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA1 protein; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of HSD3B protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin promotes the reaction [FSHB protein results in increased phosphorylation of PRKAA1 protein]]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased expression of HSD3B protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in decreased secretion of Progesterone]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK1 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of MAPK3 protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin results in increased phosphorylation of PRKAA1 protein] PRKAA1 protein affects the susceptibility to Metformin Metformin increases expression and phosphorylation of PRKAA1 protein in epithelial cell of alveolus of lung |
CTD RGD |
PMID:16380484 PMID:16760380 PMID:16873680 PMID:19052259 PMID:19594306 PMID:21054339 PMID:21186350 PMID:22815988 PMID:24428821 PMID:25601987 PMID:26497364 PMID:31974165 PMID:37121296 PMID:37481222 PMID:23632475 More...
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RGD:150404268 |
NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978
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G |
Prkaa2 |
protein kinase AMP-activated catalytic subunit alpha 2 |
multiple interactions affects response to substance increases activity increases phosphorylation |
ISO EXP |
Metformin inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased phosphorylation of PRKAA2 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein [[PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin] which results in decreased abundance of Adenosine Triphosphate; [[PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin] which results in increased abundance of Glucose-6-Phosphate; [PRKAA1 gene co-treated with PRKAA2 gene] affects the susceptibility to Metformin; [PRKAA1 gene mutant form co-treated with PRKAA2 gene mutant form] affects the susceptibility to Metformin; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein; PRKAA2 protein affects the reaction [Metformin results in increased expression of PPARGC1A mRNA] 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein]; Metformin results in increased phosphorylation of and results in increased activity of PRKAA2 protein PRKAA2 protein affects the susceptibility to Metformin Metformin results in increased activity of PRKAA2 protein Metformin results in increased phosphorylation of PRKAA2 protein metformin inhibits the reaction [lipopolysaccharide decreases expression of Prkaa2 mRNA in left cardiac chamber] and decreases expression of Prkaa2 mRNA in left cardiac chamber |
CTD RGD |
PMID:16873680 PMID:18484962 PMID:19052259 PMID:19594306 PMID:20847317 PMID:21186350 PMID:24428821 PMID:31974165 PMID:37481222 PMID:27621180 More...
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RGD:39456138 |
NCBI chr 5:119,807,992...119,879,987
Ensembl chr 5:119,813,226...119,879,543
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G |
Prkab2 |
protein kinase AMP-activated non-catalytic subunit beta 2 |
increases expression |
EXP |
Metformin results in increased expression of PRKAB2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:185,257,218...185,272,846
Ensembl chr 2:185,257,213...185,269,872
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G |
Prkag2 |
protein kinase AMP-activated non-catalytic subunit gamma 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Olanzapine results in increased expression of PRKAG2 mRNA] |
CTD |
PMID:32652086 |
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NCBI chr 4:10,010,890...10,252,155
Ensembl chr 4:10,010,890...10,252,142
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G |
Prkca |
protein kinase C, alpha |
multiple interactions decreases expression |
ISO |
[Metformin co-treated with Pioglitazone] results in decreased expression of PRKCA mRNA; Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of PRKCA protein] Metformin results in decreased expression of PRKCA mRNA |
CTD |
PMID:20590612 PMID:32589349 |
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NCBI chr10:92,889,390...93,288,013
Ensembl chr10:92,894,012...93,288,012
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G |
Prkcb |
protein kinase C, beta |
decreases expression multiple interactions |
ISO |
Metformin results in decreased expression of PRKCB mRNA; Metformin results in decreased expression of PRKCB protein Metformin inhibits the reaction [INS protein results in increased expression of PRKCB protein] |
CTD |
PMID:15531508 PMID:36764371 |
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NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536
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G |
Prl |
prolactin |
decreases secretion |
ISO |
Metformin results in decreased secretion of PRL protein |
CTD |
PMID:21664031 |
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NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062
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G |
Psat1 |
phosphoserine aminotransferase 1 |
increases expression |
EXP |
Metformin results in increased expression of PSAT1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:213,196,709...213,218,564
Ensembl chr 1:213,196,709...213,218,682
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G |
Pten |
phosphatase and tensin homolog |
multiple interactions |
EXP |
Metformin inhibits the reaction [Testosterone results in decreased expression of PTEN mRNA] |
CTD |
PMID:26492952 |
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NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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G |
Ptgfr |
prostaglandin F receptor |
decreases expression |
EXP |
Metformin results in decreased expression of PTGFR mRNA |
CTD |
PMID:31324951 |
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NCBI chr 2:240,731,185...240,766,674
Ensembl chr 2:240,733,375...240,765,650
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases expression |
EXP ISO |
Metformin inhibits the reaction [Dietary Fats results in increased expression of PTGS2 protein] Metformin results in decreased expression of PTGS2 mRNA |
CTD |
PMID:27551045 PMID:33838154 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Ptpn1 |
protein tyrosine phosphatase, non-receptor type 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [INS protein results in increased expression of PTPN1 protein] |
CTD |
PMID:30928401 |
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NCBI chr 3:156,638,811...156,687,503
Ensembl chr 3:156,638,769...156,687,504
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G |
Pxmp4 |
peroxisomal membrane protein 4 |
increases expression |
EXP |
Metformin results in increased expression of PXMP4 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 3:143,093,371...143,110,620
Ensembl chr 3:143,093,018...143,110,651
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G |
Pycr1 |
pyrroline-5-carboxylate reductase 1 |
increases expression |
EXP |
Metformin results in increased expression of PYCR1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr10:105,917,732...105,922,658
Ensembl chr10:105,917,680...105,922,549
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G |
Pygl |
glycogen phosphorylase L |
decreases expression |
EXP |
Metformin results in decreased expression of PYGL mRNA |
CTD |
PMID:25596134 |
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NCBI chr 6:88,697,598...88,740,260
Ensembl chr 6:88,697,593...88,740,310
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G |
Rab11a |
RAB11a, member RAS oncogene family |
increases expression multiple interactions |
ISO |
Metformin results in increased expression of RAB11A protein Metformin inhibits the reaction [Ethinyl Estradiol results in decreased expression of RAB11A protein] |
CTD |
PMID:34058177 |
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NCBI chr 8:65,223,698...65,246,461
Ensembl chr 8:65,222,949...65,246,525
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G |
Rab33a |
RAB33A, member RAS oncogene family |
increases expression |
EXP |
Metformin results in increased expression of RAB33A mRNA |
CTD |
PMID:25596134 |
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NCBI chr X:127,694,219...127,706,378
Ensembl chr X:127,694,964...127,706,378
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G |
Rab5a |
RAB5A, member RAS oncogene family |
multiple interactions |
EXP |
Metformin promotes the reaction [APPL1 protein binds to RAB5A protein] |
CTD |
PMID:29991592 |
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NCBI chr 9:6,483,906...6,512,877
Ensembl chr 9:6,484,469...6,512,873
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G |
Rad51c |
RAD51 paralog C |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of RAD51C mRNA] |
CTD |
PMID:29095437 |
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NCBI chr10:72,205,032...72,231,643
Ensembl chr10:72,205,032...72,231,248
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G |
Raf1 |
Raf-1 proto-oncogene, serine/threonine kinase |
decreases phosphorylation |
ISO |
Metformin results in decreased phosphorylation of RAF1 protein |
CTD |
PMID:23707609 |
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NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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G |
Rbp4 |
retinol binding protein 4 |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased secretion of RBP4 protein] |
CTD |
PMID:19080170 |
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NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
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G |
Rbp7 |
retinol binding protein 7 |
increases expression |
EXP |
Metformin results in increased expression of RBP7 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 5:159,889,723...159,894,338
Ensembl chr 5:159,889,723...159,894,339
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G |
Rd3l |
RD3 like |
decreases expression |
EXP |
Metformin results in decreased expression of RD3L mRNA |
CTD |
PMID:31324951 |
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NCBI chr 6:131,042,274...131,044,178
Ensembl chr 6:131,042,185...131,044,163
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G |
Reg3g |
regenerating family member 3 gamma |
increases expression |
EXP |
Metformin results in increased expression of REG3G mRNA |
CTD |
PMID:31324951 |
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NCBI chr 4:110,922,805...110,927,803
Ensembl chr 4:110,924,168...110,926,723
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases localization multiple interactions decreases phosphorylation |
ISO EXP |
Metformin results in decreased localization of RELA protein [Paclitaxel co-treated with Metformin] results in decreased expression of RELA mRNA; Metformin inhibits the reaction [IL1B protein results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [RELA protein results in increased expression of ABCB1 mRNA]; Metformin results in decreased expression of and affects the localization of RELA protein; PRKAA1 protein affects the reaction [Metformin results in decreased expression of RELA protein] Metformin results in decreased phosphorylation of RELA protein dorsomorphin inhibits the reaction [Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]]; Metformin inhibits the reaction [Dehydroepiandrosterone affects the localization of RELA protein]; Metformin inhibits the reaction [Fructose results in increased phosphorylation of RELA protein]; Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]; Niacinamide inhibits the reaction [Metformin inhibits the reaction [Palmitic Acid results in increased phosphorylation of RELA protein]] Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased phosphorylation of RELA protein] |
CTD |
PMID:16385087 PMID:21054339 PMID:25108154 PMID:27634381 PMID:29309887 PMID:37120126 More...
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Retn |
resistin |
multiple interactions |
EXP |
Metformin inhibits the reaction [Fructose results in increased expression of RETN protein]; Metformin inhibits the reaction [Letrozole results in increased expression of RETN mRNA] |
CTD |
PMID:25108154 PMID:32298659 |
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NCBI chr12:1,710,881...1,712,621
Ensembl chr12:1,710,881...1,712,620
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G |
Rffl |
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase |
decreases expression |
EXP |
Metformin results in decreased expression of RFFL mRNA |
CTD |
PMID:25596134 |
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NCBI chr10:67,740,711...67,803,669
Ensembl chr10:67,740,712...67,824,434
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G |
RGD1309362 |
similar to interferon-inducible GTPase |
increases expression |
EXP |
Metformin results in increased expression of RGD1309362 mRNA |
CTD |
PMID:31324951 |
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G |
Rgs2 |
regulator of G-protein signaling 2 |
decreases expression |
EXP |
Metformin results in decreased expression of RGS2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr13:55,799,749...55,802,354
Ensembl chr13:55,798,829...55,802,385
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G |
Rhd |
Rh blood group, D antigen |
decreases expression |
EXP |
Metformin results in decreased expression of RHD mRNA |
CTD |
PMID:31324951 |
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NCBI chr 5:147,087,479...147,121,716
Ensembl chr 5:147,087,518...147,121,715
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G |
Rhoa |
ras homolog family member A |
decreases expression |
ISO |
Metformin results in decreased expression of RHOA protein |
CTD |
PMID:37121296 |
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NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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G |
Rhobtb1 |
Rho-related BTB domain containing 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of RHOBTB1 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr20:19,327,142...19,456,121
Ensembl chr20:19,327,155...19,403,012
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G |
Rictor |
RPTOR independent companion of MTOR, complex 2 |
multiple interactions decreases expression |
ISO |
[Metformin co-treated with Pioglitazone] results in decreased expression of RICTOR mRNA Metformin results in decreased expression of RICTOR mRNA |
CTD |
PMID:32589349 |
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NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
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G |
Ripk1 |
receptor interacting serine/threonine kinase 1 |
multiple interactions |
ISO |
[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; [Simvastatin co-treated with Metformin] results in increased expression of RIPK1 protein; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]] |
CTD |
PMID:25412314 |
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NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
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G |
Ripk2 |
receptor-interacting serine-threonine kinase 2 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of RIPK2 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 5:29,630,806...29,662,804
Ensembl chr 5:29,631,570...29,662,657
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G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
multiple interactions |
ISO |
[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]; necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]; RIPK3 protein affects the reaction [necrostatin-1 inhibits the reaction [[Simvastatin co-treated with Metformin] promotes the reaction [RIPK3 protein binds to RIPK1 protein]]] |
CTD |
PMID:25412314 |
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NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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G |
Rlf |
RLF zinc finger |
increases expression |
EXP |
Metformin results in increased expression of RLF mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:134,711,612...134,767,274
Ensembl chr 5:134,711,619...134,767,257
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G |
Rnasel |
ribonuclease L |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of RNASEL mRNA] |
CTD |
PMID:29095437 |
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NCBI chr13:65,894,990...65,910,354
Ensembl chr13:65,901,459...65,908,704
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G |
Rnd1 |
Rho family GTPase 1 |
affects expression |
EXP |
Metformin affects the expression of RND1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 7:129,821,311...129,828,385
Ensembl chr 7:129,821,311...129,828,399
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G |
Rnd3 |
Rho family GTPase 3 |
affects expression increases expression |
EXP |
Metformin affects the expression of RND3 mRNA Metformin results in increased expression of RND3 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
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NCBI chr 3:35,571,929...35,589,283
Ensembl chr 3:35,571,143...35,589,327
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G |
Rnf121 |
ring finger protein 121 |
increases expression |
EXP |
Metformin results in increased expression of RNF121 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:156,377,368...156,439,936
Ensembl chr 1:156,377,364...156,446,826
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G |
Ro60 |
Ro60, Y RNA binding protein |
affects expression |
EXP |
Metformin affects the expression of RO60 mRNA |
CTD |
PMID:25596134 |
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NCBI chr13:55,499,514...55,520,504
Ensembl chr13:55,499,534...55,520,504
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G |
Rps6 |
ribosomal protein S6 |
decreases phosphorylation multiple interactions |
ISO EXP |
Metformin results in decreased phosphorylation of RPS6 protein Metformin analog results in decreased phosphorylation of RPS6 protein; Metformin results in decreased phosphorylation of RPS6 protein Trientine inhibits the reaction [Metformin results in decreased phosphorylation of RPS6 protein] |
CTD |
PMID:22492524 PMID:23363784 |
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NCBI chr 5:101,371,716...101,374,576
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G |
Rps6ka2 |
ribosomal protein S6 kinase A2 |
multiple interactions increases expression |
ISO |
[Metformin co-treated with Pioglitazone] results in increased expression of RPS6KA2 mRNA Metformin results in increased expression of RPS6KA2 mRNA |
CTD |
PMID:32589349 |
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NCBI chr 1:52,631,582...52,906,739
Ensembl chr 1:52,631,736...52,906,739
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G |
Rps6ka5 |
ribosomal protein S6 kinase A5 |
multiple interactions decreases expression |
ISO |
[Metformin co-treated with Pioglitazone] results in decreased expression of RPS6KA5 mRNA Metformin results in decreased expression of RPS6KA5 mRNA |
CTD |
PMID:32589349 |
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NCBI chr 6:119,828,823...120,006,190
Ensembl chr 6:119,828,846...120,006,224
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G |
Rps6kb1 |
ribosomal protein S6 kinase B1 |
multiple interactions decreases expression |
ISO |
3-benzyl-5-((2-nitrophenoxy)methyl)dihydrofuran-2(3H)-one inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]]; dorsomorphin inhibits the reaction [Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein]]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of RPS6KB1 protein] [Paclitaxel co-treated with Metformin] results in decreased expression of RPS6KB1 mRNA; Metformin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein] Metformin results in decreased expression of RPS6KB1 protein modified form |
CTD |
PMID:29309887 PMID:29859833 PMID:33838154 PMID:34432352 |
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NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
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Rrm2 |
ribonucleotide reductase regulatory subunit M2 |
increases expression |
EXP |
Metformin results in increased expression of RRM2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 6:41,339,858...41,346,774
Ensembl chr 6:41,340,557...41,346,773
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G |
Rrm2b |
ribonucleotide reductase regulatory TP53 inducible subunit M2B |
increases expression |
EXP |
Metformin results in increased expression of RRM2B mRNA |
CTD |
PMID:25596134 |
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NCBI chr 7:69,077,024...69,108,742
Ensembl chr 7:69,078,291...69,108,633
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G |
Rsl1d1 |
ribosomal L1 domain containing 1 |
increases expression |
EXP |
Metformin results in increased expression of RSL1D1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr10:4,424,868...4,436,753
Ensembl chr10:4,397,821...4,439,593
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G |
Rtn3 |
reticulon 3 |
multiple interactions |
EXP |
Metformin inhibits the reaction [Glucose results in increased expression of RTN3 protein] |
CTD |
PMID:34801538 |
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NCBI chr 1:204,612,675...204,669,212
Ensembl chr 1:204,612,675...204,669,275
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G |
Runx1 |
RUNX family transcription factor 1 |
increases expression |
EXP |
Metformin results in increased expression of RUNX1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
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G |
Runx2 |
RUNX family transcription factor 2 |
increases expression multiple interactions |
EXP ISO |
Metformin results in increased expression of RUNX2 protein Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of RUNX2 protein] |
CTD |
PMID:19594306 PMID:37409753 |
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NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
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G |
Rxra |
retinoid X receptor alpha |
decreases expression |
EXP |
Metformin results in decreased expression of RXRA mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:10,989,832...11,076,366
Ensembl chr 3:10,989,832...11,073,712
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G |
Sall1 |
spalt-like transcription factor 1 |
increases expression |
EXP |
Metformin results in increased expression of SALL1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr19:18,005,782...18,022,705
Ensembl chr19:18,007,503...18,022,705
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G |
Samt2 |
spermatogenesis associated multipass transmembrane protein 2 |
increases expression |
EXP |
Metformin results in increased expression of SAMT2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr X:23,355,211...23,407,134
Ensembl chr X:23,342,423...23,358,120
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G |
Sars1 |
seryl-tRNA synthetase 1 |
increases expression |
EXP |
Metformin results in increased expression of SARS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:196,065,543...196,081,240
Ensembl chr 2:196,065,430...196,081,277
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G |
Sat1 |
spermidine/spermine N1-acetyl transferase 1 |
increases expression |
EXP |
Metformin results in increased expression of SAT1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr X:40,158,354...40,161,641
Ensembl chr X:40,157,046...40,196,813
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G |
Sbk1 |
SH3 domain binding kinase 1 |
increases expression |
EXP |
Metformin results in increased expression of SBK1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:180,807,092...180,851,910
Ensembl chr 1:180,807,099...180,851,885
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G |
Scamp1 |
secretory carrier membrane protein 1 |
increases expression |
EXP |
Metformin results in increased expression of SCAMP1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:25,433,958...25,516,734
Ensembl chr 2:25,433,959...25,516,673
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G |
Scd |
stearoyl-CoA desaturase |
multiple interactions decreases expression |
ISO EXP |
[Metformin co-treated with caffeic acid] results in decreased expression of SCD1 protein; Metformin inhibits the reaction [INS protein results in increased expression of SCD protein] Metformin results in decreased expression of SCD1 mRNA |
CTD |
PMID:28576465 PMID:31324951 PMID:36764371 |
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NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Scd3 |
stearoyl-coenzyme A desaturase 3 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of SCD3 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr 1:243,093,057...243,114,451
Ensembl chr 1:243,078,774...243,114,229
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G |
Sdf2l1 |
stromal cell-derived factor 2-like 1 |
increases expression |
EXP |
Metformin results in increased expression of SDF2L1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr11:83,872,659...83,874,902
Ensembl chr11:83,872,659...83,874,902
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G |
Sds |
serine dehydratase |
decreases expression |
EXP |
Metformin results in decreased expression of SDS mRNA |
CTD |
PMID:31324951 |
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NCBI chr12:36,083,226...36,090,540
Ensembl chr12:36,083,229...36,088,203
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G |
Sec23b |
Sec23 homolog B, COPII coat complex component |
increases expression |
EXP |
Metformin results in increased expression of SEC23B mRNA |
CTD |
PMID:31324951 |
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NCBI chr 3:131,939,011...131,981,489
Ensembl chr 3:131,939,337...131,981,489
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G |
Sec62 |
SEC62 homolog, preprotein translocation factor |
multiple interactions |
EXP |
Metformin inhibits the reaction [Glucose results in increased expression of SEC62 protein] |
CTD |
PMID:34801538 |
|
NCBI chr 2:112,570,810...112,598,198
Ensembl chr 2:112,570,819...112,601,814
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G |
Selenop |
selenoprotein P |
multiple interactions |
EXP |
Metformin inhibits the reaction [Dexamethasone results in increased expression of SELENOP mRNA]; Metformin inhibits the reaction [Dexamethasone results in increased secretion of SELENOP protein]; Metformin inhibits the reaction [Glucose results in increased expression of SELENOP mRNA]; Metformin inhibits the reaction [Glucose results in increased secretion of SELENOP protein] |
CTD |
PMID:19576170 |
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NCBI chr 2:52,498,123...52,508,409
Ensembl chr 2:52,498,339...52,508,852
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G |
Selp |
selectin P |
multiple interactions |
EXP |
Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of SELP protein]] |
CTD |
PMID:36547818 |
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NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845
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G |
Sephs2 |
selenophosphate synthetase 2 |
multiple interactions |
EXP |
Metformin inhibits the reaction [Dexamethasone results in increased expression of SEPHS2 mRNA] |
CTD |
PMID:19576170 |
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NCBI chr 1:181,893,146...181,895,464
Ensembl chr 1:181,892,599...181,895,497
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G |
Serpinc1 |
serpin family C member 1 |
increases activity |
ISO |
Metformin results in increased activity of SERPINC1 protein |
CTD |
PMID:29458015 |
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NCBI chr13:73,257,208...73,271,476
Ensembl chr13:73,257,179...73,284,293
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
EXP |
Metformin inhibits the reaction [Fructose results in increased expression of SERPINE1 protein] |
CTD |
PMID:25108154 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Sertad1 |
SERTA domain containing 1 |
decreases expression |
EXP |
Metformin results in decreased expression of SERTAD1 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 1:82,775,692...82,778,961
Ensembl chr 1:82,775,252...82,779,091
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G |
Sesn1 |
sestrin 1 |
decreases expression |
EXP |
Metformin results in decreased expression of SESN1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr20:45,294,876...45,387,698
Ensembl chr20:45,294,871...45,387,697
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G |
Sesn2 |
sestrin 2 |
multiple interactions decreases expression |
ISO EXP |
[Metformin co-treated with Rotenone] results in increased expression of SESN2 protein Metformin results in decreased expression of SESN2 mRNA |
CTD |
PMID:26031332 PMID:31324951 |
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NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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G |
Setx |
senataxin |
decreases expression |
EXP |
Metformin results in decreased expression of SETX mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:12,428,091...12,480,801
Ensembl chr 3:12,427,635...12,480,803
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G |
Sez6 |
seizure related 6 homolog |
decreases expression |
EXP |
Metformin results in decreased expression of SEZ6 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr10:62,818,931...62,868,686
Ensembl chr10:62,819,069...62,868,671
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G |
Sfn |
stratifin |
increases expression |
EXP |
Metformin results in increased expression of SFN mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
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G |
Sgk1 |
serum/glucocorticoid regulated kinase 1 |
affects expression |
EXP |
Metformin affects the expression of SGK1 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr 1:22,980,257...23,098,122
Ensembl chr 1:22,980,261...23,098,283
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G |
Sgk2 |
serum/glucocorticoid regulated kinase 2 |
increases expression |
EXP |
Metformin results in increased expression of SGK2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 3:151,644,102...151,669,480
Ensembl chr 3:151,644,102...151,669,480
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G |
Sh3bp5 |
SH3-domain binding protein 5 |
decreases expression |
EXP |
Metformin results in decreased expression of SH3BP5 mRNA |
CTD |
PMID:31324951 |
|
NCBI chr16:6,583,462...6,678,344
Ensembl chr16:6,583,465...6,698,975
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G |
Siah2 |
siah E3 ubiquitin protein ligase 2 |
decreases expression |
EXP |
Metformin results in decreased expression of SIAH2 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr 2:142,913,924...142,931,752
Ensembl chr 2:142,914,003...142,931,950
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G |
Sik1 |
salt-inducible kinase 1 |
decreases expression |
EXP |
Metformin results in decreased expression of SIK1 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
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NCBI chr20:9,949,407...9,959,036
Ensembl chr20:9,947,396...9,958,991
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G |
Sirt1 |
sirtuin 1 |
multiple interactions increases expression increases phosphorylation |
ISO EXP |
SIRT1 protein affects the reaction [Metformin affects the expression of NAMPT mRNA] [Niacinamide results in decreased activity of SIRT1 protein] which results in decreased susceptibility to Metformin; Metformin inhibits the reaction [Fructose results in decreased expression of SIRT1 protein]; Metformin promotes the reaction [Arsenic Trioxide results in increased expression of SIRT1 protein] Metformin results in increased expression of SIRT1 protein Metformin inhibits the reaction [Ethinyl Estradiol results in decreased phosphorylation of SIRT1 protein]; Metformin inhibits the reaction [Glucose results in decreased expression of SIRT1 protein]; SIRT1 mutant form inhibits the reaction [Metformin results in increased expression of PPARGC1A mRNA] Metformin results in increased expression of SIRT1 mRNA Metformin results in increased phosphorylation of SIRT1 protein |
CTD |
PMID:23090186 PMID:23166782 PMID:23315983 PMID:24428821 PMID:24687991 PMID:25108154 PMID:31332900 PMID:32808185 PMID:34058177 More...
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NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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G |
Sirt2 |
sirtuin 2 |
increases expression |
ISO |
Metformin results in increased expression of SIRT2 mRNA; Metformin results in increased expression of SIRT2 protein |
CTD |
PMID:24687991 |
|
NCBI chr 1:84,053,883...84,076,975
Ensembl chr 1:84,052,903...84,076,975
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G |
Sirt3 |
sirtuin 3 |
multiple interactions decreases response to substance decreases expression increases expression |
ISO EXP |
Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]; SIRT3 promotes the reaction [Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]]; SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased cleavage of CASP3 protein]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX mRNA]]; SIRT3 protein promotes the reaction [Metformin inhibits the reaction [Cisplatin results in increased expression of BAX protein]] SIRT3 protein results in decreased susceptibility to Metformin Metformin results in decreased expression of SIRT3 mRNA; Metformin results in decreased expression of SIRT3 protein Metformin results in increased expression of SIRT3 protein [Arsenic Trioxide co-treated with Metformin] results in increased expression of SIRT3 protein; Metformin inhibits the reaction [Cisplatin results in decreased expression of SIRT3 mRNA]; Metformin inhibits the reaction [Cisplatin results in decreased expression of SIRT3 protein] Metformin results in increased expression of and results in increased activity of SIRT3 protein |
CTD |
PMID:23166782 PMID:24687991 PMID:30385301 PMID:33147367 PMID:36800006 |
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NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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G |
Sirt4 |
sirtuin 4 |
increases expression |
ISO |
Metformin results in increased expression of SIRT4 mRNA |
CTD |
PMID:24687991 |
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NCBI chr12:41,125,533...41,139,440
Ensembl chr12:41,131,262...41,139,439
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G |
Sirt5 |
sirtuin 5 |
decreases expression |
ISO |
Metformin results in decreased expression of SIRT5 protein |
CTD |
PMID:24687991 |
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NCBI chr17:21,310,028...21,337,137
Ensembl chr17:21,310,028...21,337,101
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G |
Sirt7 |
sirtuin 7 |
decreases expression |
ISO |
Metformin results in decreased expression of SIRT7 mRNA |
CTD |
PMID:24687991 |
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NCBI chr10:105,896,476...105,903,301
Ensembl chr10:105,896,476...105,903,172
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G |
Siva1 |
SIVA1, apoptosis-inducing factor |
decreases expression |
EXP |
Metformin results in decreased expression of SIVA1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 6:131,705,323...131,709,697
Ensembl chr 6:131,705,323...131,709,690
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G |
Skp2 |
S-phase kinase associated protein 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of SKP2 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr 2:58,161,226...58,189,293
Ensembl chr 2:58,161,229...58,189,338
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G |
Slc10a1 |
solute carrier family 10 member 1 |
decreases expression multiple interactions |
ISO |
Metformin results in decreased expression of SLC10A1 mRNA; Metformin results in decreased expression of SLC10A1 protein [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of SLC10A1 mRNA; [Metformin co-treated with Ethinyl Estradiol] results in decreased expression of SLC10A1 protein |
CTD |
PMID:34058177 |
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NCBI chr 6:100,613,045...100,626,670
Ensembl chr 6:100,613,045...100,626,670
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G |
Slc10a2 |
solute carrier family 10 member 2 |
multiple interactions increases expression |
ISO |
Metformin inhibits the reaction [Ethinyl Estradiol results in decreased expression of SLC10A2 protein] Metformin results in increased expression of SLC10A2 protein |
CTD |
PMID:34058177 |
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NCBI chr16:84,386,528...84,409,475
Ensembl chr16:84,374,862...84,409,475
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G |
Slc12a8 |
solute carrier family 12, member 8 |
increases expression |
EXP |
Metformin results in increased expression of SLC12A8 mRNA |
CTD |
PMID:25596134 |
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NCBI chr11:67,116,876...67,266,548
Ensembl chr11:67,116,877...67,266,834
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G |
Slc15a1 |
solute carrier family 15 member 1 |
multiple interactions increases expression |
ISO |
Metformin inhibits the reaction [rosiglitazone results in increased expression of and results in increased activity of SLC15A1 protein]; Metformin results in decreased activity of and results in decreased expression of SLC15A1 protein Metformin inhibits the reaction [rosiglitazone results in increased activity of SLC15A1 protein] Metformin results in increased expression of SLC15A1 mRNA |
CTD |
PMID:22108913 |
|
NCBI chr15:98,537,641...98,582,544
Ensembl chr15:98,537,641...98,582,545
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G |
Slc16a10 |
solute carrier family 16 member 10 |
decreases expression |
EXP |
Metformin results in decreased expression of SLC16A10 mRNA |
CTD |
PMID:31324951 |
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NCBI chr20:43,454,819...43,567,839
Ensembl chr20:43,459,709...43,567,839
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G |
Slc16a6 |
solute carrier family 16, member 6 |
increases expression |
EXP |
Metformin results in increased expression of SLC16A6 mRNA |
CTD |
PMID:25596134 |
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NCBI chr10:94,424,377...94,447,482
Ensembl chr10:94,426,244...94,448,779
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G |
Slc19a2 |
solute carrier family 19 member 2 |
decreases expression |
EXP |
Metformin results in decreased expression of SLC19A2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr13:76,601,975...76,616,175
Ensembl chr13:76,601,900...76,616,172
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G |
Slc19a3 |
solute carrier family 19 member 3 |
multiple interactions increases uptake |
ISO |
Amprolium inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Famotidine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]; Phenformin inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Verapamil inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin] |
CTD |
PMID:26528626 |
|
NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
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G |
Slc1a4 |
solute carrier family 1 member 4 |
increases expression |
EXP |
Metformin results in increased expression of SLC1A4 mRNA |
CTD |
PMID:25596134 |
|
NCBI chr14:94,530,801...94,560,190
Ensembl chr14:94,529,084...94,560,418
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions increases response to substance increases uptake |
ISO |
Imipramine inhibits the reaction [SLC22A1 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] SLC22A1 protein results in increased susceptibility to Metformin |
CTD |
PMID:16141367 PMID:20956498 PMID:25106415 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slc22a2 |
solute carrier family 22 member 2 |
multiple interactions affects transport decreases transport increases uptake increases transport |
ISO EXP |
Bisoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; carvedilol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Metoprolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; Ondansetron inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin]; Phenoxybenzamine inhibits the reaction [SLC22A2 protein affects the transport of Metformin]; Propranolol inhibits the reaction [SLC22A2 protein results in increased uptake of Metformin] SLC22A2 protein mutant form results in decreased transport of Metformin SLC22A2 protein results in increased transport of Metformin |
CTD |
PMID:16141367 PMID:18230276 PMID:18728938 PMID:19740083 PMID:24001450 PMID:32305507 More...
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NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
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G |
Slc22a3 |
solute carrier family 22 member 3 |
multiple interactions increases uptake |
ISO EXP |
carvedilol inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]; Cimetidine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]; Imipramine inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Verapamil inhibits the reaction [SLC22A3 protein results in increased uptake of Metformin] [1-Methyl-4-phenylpyridinium results in decreased activity of [SLC22A3 protein co-treated with SLC47A1 protein]] which results in decreased transport of Metformin |
CTD |
PMID:16141367 PMID:21697722 PMID:23562376 |
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NCBI chr 1:48,235,476...48,324,617
Ensembl chr 1:48,235,476...48,324,612
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G |
Slc22a4 |
solute carrier family 22 member 4 |
decreases expression multiple interactions |
EXP ISO |
Metformin results in decreased expression of SLC22A4 mRNA Metformin inhibits the reaction [SLC22A4 protein results in increased abundance of Doxorubicin] |
CTD |
PMID:31324951 PMID:37453608 |
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NCBI chr10:38,133,333...38,179,932
Ensembl chr10:38,133,322...38,179,720
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G |
Slc22a5 |
solute carrier family 22 member 5 |
increases expression multiple interactions |
EXP ISO |
Metformin results in increased expression of SLC22A5 mRNA Metformin inhibits the reaction [SLC22A5 protein results in increased abundance of Doxorubicin] |
CTD |
PMID:31324951 PMID:37453608 |
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NCBI chr10:38,008,303...38,035,474
Ensembl chr10:38,008,311...38,035,309
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G |
Slc25a20 |
solute carrier family 25 member 20 |
decreases expression |
EXP |
Metformin results in decreased expression of SLC25A20 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 8:109,365,056...109,386,512
Ensembl chr 8:109,365,002...109,386,512
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Slc25a37 |
solute carrier family 25 member 37 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of SLC25A37 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr15:44,534,280...44,576,697
Ensembl chr15:44,536,727...44,577,199
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Slc25a47 |
solute carrier family 25, member 47 |
increases expression |
EXP |
Metformin results in increased expression of SLC25A47 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 6:127,767,365...127,773,000
Ensembl chr 6:127,767,305...127,773,005
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Slc29a4 |
solute carrier family 29 member 4 |
multiple interactions |
ISO |
Metformin inhibits the reaction [SLC29A4 protein results in increased abundance of Doxorubicin] |
CTD |
PMID:37453608 |
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NCBI chr12:11,853,540...11,884,660
Ensembl chr12:11,853,540...11,874,834
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Slc2a2 |
solute carrier family 2 member 2 |
increases response to substance increases phosphorylation multiple interactions |
ISO |
SLC2A2 intron SNP results in increased susceptibility to Metformin Metformin results in increased phosphorylation of SLC2A2 protein Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A2 protein] |
CTD |
PMID:26835874 PMID:27500523 PMID:36764371 |
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NCBI chr 2:111,609,798...111,639,930
Ensembl chr 2:111,611,774...111,639,933
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G |
Slc2a4 |
solute carrier family 2 member 4 |
multiple interactions increases expression decreases expression |
ISO EXP |
Metformin affects the reaction [Testosterone results in decreased expression of SLC2A4]; Metformin inhibits the reaction [INS protein results in decreased expression of SLC2A4 protein] Metformin results in increased expression of SLC2A4 mRNA; Metformin results in increased expression of SLC2A4 protein Metformin inhibits the reaction [[Dietary Fats co-treated with Fructose] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein]; Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]; Metformin inhibits the reaction [Letrozole results in decreased expression of SLC2A4 mRNA] Metformin results in decreased expression of SLC2A4 mRNA Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased expression of SLC2A4 protein]; SIRT3 promotes the reaction [Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]] |
CTD |
PMID:15864539 PMID:18322300 PMID:19080170 PMID:19328476 PMID:20724125 PMID:21870829 PMID:23457588 PMID:29991592 PMID:30256492 PMID:30914352 PMID:31743741 PMID:32298659 PMID:36800006 More...
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NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Slc2a5 |
solute carrier family 2 member 5 |
increases expression |
EXP |
Metformin results in increased expression of SLC2A5 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 5:160,583,055...160,609,994
Ensembl chr 5:160,583,234...160,611,106
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G |
Slc3a2 |
solute carrier family 3 member 2 |
increases expression |
EXP |
Metformin results in increased expression of SLC3A2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931
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G |
Slc41a3 |
solute carrier family 41, member 3 |
decreases expression |
EXP |
Metformin results in decreased expression of SLC41A3 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 4:123,109,555...123,154,766
Ensembl chr 4:123,112,748...123,154,766
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Slc46a3 |
solute carrier family 46, member 3 |
decreases expression |
EXP |
Metformin results in decreased expression of SLC46A3 mRNA |
CTD |
PMID:31324951 |
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NCBI chr12:7,140,610...7,157,093
Ensembl chr12:7,140,668...7,157,092
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Slc47a1 |
solute carrier family 47 member 1 |
affects abundance multiple interactions increases uptake increases secretion decreases uptake |
ISO EXP |
SLC47A1 protein affects the abundance of Metformin Cadmium inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC47A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Ondansetron inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]; Pyrimethamine inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin] Cadmium inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin]; Ondansetron inhibits the reaction [SLC47A1 protein results in increased uptake of Metformin] SLC47A1 protein results in increased secretion of Metformin [1-Methyl-4-phenylpyridinium results in decreased activity of [SLC22A3 protein co-treated with SLC47A1 protein]] which results in decreased transport of Metformin SLC47A1 protein polymorphism results in decreased uptake of Metformin |
CTD |
PMID:19172157 PMID:21991918 PMID:22419765 PMID:23562376 PMID:24001450 PMID:27871888 More...
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NCBI chr10:46,034,115...46,088,617
Ensembl chr10:46,034,122...46,087,637
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Slc47a2 |
solute carrier family 47 member 2 |
increases uptake multiple interactions |
ISO |
SLC47A2 protein results in increased uptake of Metformin Cadmium inhibits the reaction [SLC47A2 protein results in increased uptake of Metformin]; Metformin inhibits the reaction [SLC47A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]; Ondansetron inhibits the reaction [SLC47A2 protein results in increased uptake of Metformin] |
CTD |
PMID:22419765 PMID:24001450 PMID:27871888 |
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NCBI chr10:45,990,806...46,033,937
Ensembl chr10:45,991,095...46,033,904
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Slc4a1 |
solute carrier family 4 member 1 (Diego blood group) |
decreases expression |
EXP |
Metformin results in decreased expression of SLC4A1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr10:87,306,865...87,323,132
Ensembl chr10:87,306,872...87,323,117
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Slc6a6 |
solute carrier family 6 member 6 |
increases expression |
EXP |
Metformin results in increased expression of SLC6A6 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 4:124,195,186...124,268,880
Ensembl chr 4:124,195,218...124,268,875
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Slc6a9 |
solute carrier family 6 member 9 |
increases expression |
EXP |
Metformin results in increased expression of SLC6A9 mRNA |
CTD |
PMID:25596134 PMID:31324951 |
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NCBI chr 5:131,374,562...131,408,733
Ensembl chr 5:131,374,542...131,408,728
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Slc7a1 |
solute carrier family 7 member 1 |
increases expression |
EXP |
Metformin results in increased expression of SLC7A1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:6,628,288...6,703,849
Ensembl chr12:6,628,007...6,703,849
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Slc7a11 |
solute carrier family 7 member 11 |
increases expression |
EXP |
Metformin results in increased expression of SLC7A11 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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Slc7a5 |
solute carrier family 7 member 5 |
increases expression |
EXP |
Metformin results in increased expression of SLC7A5 mRNA |
CTD |
PMID:25596134 |
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NCBI chr19:49,935,220...49,963,823
Ensembl chr19:49,935,220...49,963,823
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Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
decreases expression increases expression multiple interactions |
EXP ISO |
Metformin results in decreased expression of SLCO1A2 mRNA Metformin results in increased expression of SLCO1A4 mRNA [Ethinyl Estradiol co-treated with Metformin] results in decreased expression of SLCO1A4 mRNA |
CTD |
PMID:19022234 PMID:34058177 |
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NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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Slco2b1 |
solute carrier organic anion transporter family, member 2b1 |
decreases expression |
EXP ISO |
Metformin results in decreased expression of SLCO2B1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:153,959,288...154,007,294
Ensembl chr 1:153,959,293...154,007,353
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G |
Smagp |
small cell adhesion glycoprotein |
decreases expression |
EXP |
Metformin results in decreased expression of SMAGP mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:131,720,260...131,738,711
Ensembl chr 7:131,718,740...131,738,691
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Snai2 |
snail family transcriptional repressor 2 |
increases expression |
EXP |
Metformin results in increased expression of SNAI2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr11:86,182,788...86,186,203
Ensembl chr11:86,181,909...86,186,200
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Snora30 |
small nucleolar RNA, H/ACA box 30 |
decreases expression |
EXP |
Metformin results in decreased expression of SNORA30 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:182,139,388...182,139,521
Ensembl chr 1:182,139,388...182,139,521
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Snord13 |
small nucleolar RNA, C/D box 13 |
decreases expression |
EXP |
Metformin results in decreased expression of SNORD13 mRNA |
CTD |
PMID:31324951 |
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NCBI chr16:60,988,909...60,989,013
Ensembl chr16:60,988,909...60,989,013
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Sod1 |
superoxide dismutase 1 |
multiple interactions |
EXP ISO |
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in decreased expression of SOD1 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of SOD1 protein] |
CTD |
PMID:35085591 PMID:36999408 PMID:37120126 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2 |
superoxide dismutase 2 |
increases expression multiple interactions |
ISO |
Metformin results in increased expression of SOD2 mRNA PRKAA1 protein affects the reaction [Metformin results in increased expression of SOD2 mRNA] |
CTD |
PMID:16380484 |
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NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Son |
SON DNA and RNA binding protein |
decreases expression |
EXP |
Metformin results in decreased expression of SON mRNA |
CTD |
PMID:25596134 |
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NCBI chr11:30,850,890...30,923,167
Ensembl chr11:30,892,005...30,923,167
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G |
Sorl1 |
sortilin related receptor 1 |
decreases expression |
EXP |
Metformin results in decreased expression of SORL1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 8:42,341,704...42,504,435
Ensembl chr 8:42,341,704...42,504,513
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Sp1 |
Sp1 transcription factor |
multiple interactions decreases expression |
ISO |
Metformin inhibits the reaction [SP1 protein results in increased expression of AHR protein] Metformin results in decreased expression of SP1 protein |
CTD |
PMID:25110054 PMID:26317792 |
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NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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Sp3 |
Sp3 transcription factor |
decreases expression |
ISO |
Metformin results in decreased expression of SP3 protein |
CTD |
PMID:26317792 |
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NCBI chr 3:57,811,855...57,857,150
Ensembl chr 3:57,812,075...57,860,342
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Sp4 |
Sp4 transcription factor |
decreases expression |
ISO |
Metformin results in decreased expression of SP4 protein |
CTD |
PMID:26317792 |
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NCBI chr 6:139,187,458...139,252,741
Ensembl chr 6:139,192,147...139,252,126
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Sp7 |
Sp7 transcription factor |
multiple interactions |
ISO |
Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 mRNA]; Metformin inhibits the reaction [BMP2 protein results in increased expression of SP7 protein] |
CTD |
PMID:37409753 |
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NCBI chr 7:133,484,609...133,494,788
Ensembl chr 7:133,484,609...133,494,847
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G |
Spmip11 |
sperm microtubule inner protein 11 |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in decreased expression of NPHS1 mRNA] |
CTD |
PMID:30551545 |
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NCBI chr 7:129,720,950...129,742,485
Ensembl chr 7:129,720,950...129,742,485
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Spsb1 |
splA/ryanodine receptor domain and SOCS box containing 1 |
increases expression |
EXP |
Metformin results in increased expression of SPSB1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:160,358,292...160,418,541
Ensembl chr 5:160,358,308...160,418,468
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Sqstm1 |
sequestosome 1 |
increases expression multiple interactions decreases expression |
EXP ISO |
Metformin results in increased expression of SQSTM1 mRNA [Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein; Chloroquine inhibits the reaction [[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein]; Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]; Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]; plantamajoside promotes the reaction [Metformin results in decreased expression of SQSTM1 protein] |
CTD |
PMID:25412314 PMID:25596134 PMID:29426000 PMID:35350904 |
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NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Srd5a3 |
steroid 5 alpha-reductase 3 |
decreases expression |
EXP |
Metformin results in decreased expression of SRD5A3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr14:32,046,408...32,060,796
Ensembl chr14:32,046,408...32,060,747
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Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions decreases expression |
ISO EXP |
[Metformin co-treated with caffeic acid] results in decreased expression of SREBF1 protein; Metformin inhibits the reaction [[cyhalothrin co-treated with Oleic Acid] results in increased expression of SREBF1 protein]; Metformin inhibits the reaction [INS protein results in increased expression of SREBF1 protein] Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 mRNA]; Metformin inhibits the reaction [[Dietary Fats co-treated with Streptozocin] results in increased expression of SREBF1 protein] Metformin results in decreased expression of SREBF1 mRNA |
CTD |
PMID:28576465 PMID:31100278 PMID:31324951 PMID:36529352 PMID:36764371 |
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NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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Srebf2 |
sterol regulatory element binding transcription factor 2 |
multiple interactions |
ISO |
Buthionine Sulfoximine inhibits the reaction [Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein]]; Metformin inhibits the reaction [AGT protein results in increased cleavage of and affects the localization of SREBF2 protein]; Metformin inhibits the reaction [AGT protein results in increased expression of SREBF2 protein]; Metformin inhibits the reaction [Hydrogen Peroxide results in increased cleavage of SREBF2 protein] Metformin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased cleavage of SREBF2 protein] |
CTD |
PMID:29499335 |
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NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848
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Srm |
spermidine synthase |
increases expression |
EXP |
Metformin results in increased expression of SRM mRNA |
CTD |
PMID:31324951 |
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NCBI chr 5:159,025,875...159,029,076
Ensembl chr 5:159,025,873...159,029,405
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G |
Srr |
serine racemase |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of SRR mRNA] |
CTD |
PMID:29095437 |
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NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011
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Sst |
somatostatin |
increases expression |
ISO |
Metformin results in increased expression of SST mRNA |
CTD |
PMID:23457588 |
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NCBI chr11:76,956,896...76,958,173
Ensembl chr11:76,956,896...76,958,173
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G |
St3gal2 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 2 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of ST3GAL2 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr19:38,888,851...38,939,874
Ensembl chr19:38,923,999...38,939,869
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
EXP |
Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]; PRKAA1 gene mutant form inhibits the reaction [Metformin inhibits the reaction [FSHB protein results in increased expression of STAR protein]] |
CTD |
PMID:16760380 |
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NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
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G |
Stk11 |
serine/threonine kinase 11 |
multiple interactions |
ISO |
Metformin inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased phosphorylation of STK11 protein] |
CTD |
PMID:37481222 |
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NCBI chr 7:9,574,553...9,591,315
Ensembl chr 7:9,575,269...9,591,315
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G |
Strbp |
spermatid perinuclear RNA binding protein |
increases expression |
EXP |
Metformin results in increased expression of STRBP mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:21,328,310...21,467,753
Ensembl chr 3:21,337,855...21,414,949
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G |
Sulf2 |
sulfatase 2 |
decreases expression |
EXP |
Metformin results in decreased expression of SULF2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 3:154,822,079...154,904,566
Ensembl chr 3:154,822,085...154,904,415
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Sult4a1 |
sulfotransferase family 4A, member 1 |
increases expression |
EXP |
Metformin results in increased expression of SULT4A1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:115,216,066...115,240,156
Ensembl chr 7:115,216,066...115,240,085
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G |
Taf15 |
TATA-box binding protein associated factor 15 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TAF15 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr10:68,272,921...68,304,951
Ensembl chr10:68,272,969...68,304,949
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G |
Taldo1 |
transaldolase 1 |
decreases expression |
EXP |
Metformin results in decreased expression of TALDO1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:196,493,634...196,503,965
Ensembl chr 1:196,493,589...196,503,974
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G |
Tanc2 |
tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 |
decreases expression |
EXP |
Metformin results in decreased expression of TANC2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr10:90,553,124...90,873,477
Ensembl chr10:90,553,002...90,868,756
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G |
Taok1 |
TAO kinase 1 |
increases expression |
EXP |
Metformin results in increased expression of TAOK1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr10:62,373,072...62,465,295
Ensembl chr10:62,381,404...62,465,766
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G |
Tbc1d4 |
TBC1 domain family, member 4 |
multiple interactions |
ISO |
Metformin inhibits the reaction [[Dietary Sugars co-treated with Dietary Fats co-treated with Streptozocin] results in decreased phosphorylation of TBC1D4 protein] |
CTD |
PMID:31743741 |
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NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265
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G |
Tbccd1 |
TBCC domain containing 1 |
increases expression |
EXP |
Metformin results in increased expression of TBCCD1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr11:78,168,386...78,205,314
Ensembl chr11:78,168,388...78,205,523
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G |
Tbx3 |
T-box transcription factor 3 |
increases expression |
EXP |
Metformin results in increased expression of TBX3 mRNA |
CTD |
PMID:31324951 |
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NCBI chr12:36,879,924...36,894,849
Ensembl chr12:36,881,445...36,893,708
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G |
Tceal7 |
transcription elongation factor A like 7 |
increases expression |
EXP |
Metformin results in increased expression of TCEAL7 mRNA |
CTD |
PMID:31324951 |
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NCBI chr X:99,228,405...99,230,551
Ensembl chr X:99,228,458...99,230,543
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G |
Tcp11l2 |
t-complex 11 like 2 |
decreases expression |
EXP |
Metformin results in decreased expression of TCP11L2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:19,150,241...19,185,135
Ensembl chr 7:19,150,252...19,185,095
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G |
Tdo2 |
tryptophan 2,3-dioxygenase |
multiple interactions decreases expression |
ISO |
Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 mRNA]; Metformin inhibits the reaction [Dexamethasone results in increased expression of TDO2 protein] Metformin results in decreased expression of TDO2 mRNA; Metformin results in decreased expression of TDO2 protein |
CTD |
PMID:25110054 |
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NCBI chr 2:167,269,581...167,287,511
Ensembl chr 2:167,269,579...167,287,511
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G |
Telo2 |
telomere maintenance 2 |
multiple interactions increases expression |
ISO |
[Metformin co-treated with Pioglitazone] results in increased expression of TELO2 mRNA Metformin results in increased expression of TELO2 mRNA |
CTD |
PMID:32589349 |
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NCBI chr10:14,120,491...14,135,729
Ensembl chr10:14,120,818...14,135,698
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G |
Tfam |
transcription factor A, mitochondrial |
increases expression |
ISO |
Metformin results in increased expression of TFAM mRNA |
CTD |
PMID:16380484 |
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NCBI chr20:17,356,243...17,368,293
Ensembl chr20:17,356,197...17,368,292
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G |
Tfe3 |
transcription factor binding to IGHM enhancer 3 |
increases expression |
EXP |
Metformin results in increased expression of TFE3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr X:14,729,547...14,742,830
Ensembl chr X:14,729,550...14,742,571
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G |
Tfrc |
transferrin receptor |
increases expression |
EXP |
Metformin results in increased expression of TFRC mRNA |
CTD |
PMID:31324951 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G |
Tgfb1 |
transforming growth factor, beta 1 |
increases expression multiple interactions |
EXP ISO |
Metformin results in increased expression of TGFB1 mRNA dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TGFB1 protein] Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TGFB1 protein]; Metformin inhibits the reaction [Folic Acid results in increased expression of TGFB1 mRNA]; Metformin inhibits the reaction [Folic Acid results in increased expression of TGFB1 protein] |
CTD |
PMID:19022234 PMID:29380373 PMID:30551545 PMID:37120126 |
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NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TH protein] |
CTD |
PMID:35085591 |
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NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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G |
Thrsp |
thyroid hormone responsive |
increases expression |
EXP |
Metformin results in increased expression of THRSP mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:151,723,415...151,727,740
Ensembl chr 1:151,723,086...151,728,075
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G |
Timm17b |
translocase of inner mitochondrial membrane 17b |
affects expression |
EXP |
Metformin affects the expression of TIMM17B mRNA |
CTD |
PMID:25596134 |
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NCBI chr X:14,596,330...14,603,491
Ensembl chr X:14,594,577...14,603,416
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G |
Timp3 |
TIMP metallopeptidase inhibitor 3 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TIMP3 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr 7:17,520,827...17,571,850
Ensembl chr 7:17,521,919...17,571,839
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G |
Tiparp |
TCDD-inducible poly(ADP-ribose) polymerase |
increases expression |
EXP |
Metformin results in increased expression of TIPARP mRNA |
CTD |
PMID:25596134 |
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NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327
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G |
Tkfc |
triokinase and FMN cyclase |
increases expression |
EXP |
Metformin results in increased expression of TKFC mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:207,238,230...207,253,035
Ensembl chr 1:207,236,557...207,252,737
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G |
Tlr1 |
toll-like receptor 1 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of TLR1 mRNA |
CTD |
PMID:29309887 |
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NCBI chr14:43,384,127...43,396,765
Ensembl chr14:43,384,932...43,397,125
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G |
Tlr2 |
toll-like receptor 2 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of TLR2 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630
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G |
Tlr3 |
toll-like receptor 3 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of TLR3 mRNA |
CTD |
PMID:29309887 |
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NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
EXP ISO |
Metformin affects the reaction [Dehydroepiandrosterone results in increased expression of TLR4 protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TLR4 mRNA]; Metformin inhibits the reaction [Isoproterenol results in increased expression of TLR4 mRNA] [Paclitaxel co-treated with Metformin] results in decreased expression of TLR4 mRNA |
CTD |
PMID:24842192 PMID:27634381 PMID:29309887 |
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NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tlr5 |
toll-like receptor 5 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of TLR5 mRNA |
CTD |
PMID:29309887 |
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NCBI chr13:94,634,778...94,658,992
Ensembl chr13:94,634,801...94,657,738
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G |
Tlr6 |
toll-like receptor 6 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of TLR6 mRNA |
CTD |
PMID:29309887 |
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NCBI chr14:43,362,164...43,374,500
Ensembl chr14:43,362,164...43,375,685
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G |
Tlr7 |
toll-like receptor 7 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of TLR7 mRNA |
CTD |
PMID:29309887 |
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NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754
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G |
Tlr8 |
toll-like receptor 8 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of TLR8 mRNA |
CTD |
PMID:29309887 |
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NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549
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G |
Tmem140 |
transmembrane protein 140 |
decreases expression |
EXP |
Metformin results in decreased expression of TMEM140 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 4:63,536,477...63,547,478
Ensembl chr 4:63,536,168...63,548,455
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G |
Tmem71 |
transmembrane protein 71 |
decreases expression |
EXP |
Metformin results in decreased expression of TMEM71 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 7:98,276,975...98,323,161
Ensembl chr 7:98,276,975...98,315,858
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G |
Tmod4 |
tropomodulin 4 |
increases expression |
EXP |
Metformin results in increased expression of TMOD4 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 2:182,695,709...182,700,540
Ensembl chr 2:182,695,709...182,700,540
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G |
Tnf |
tumor necrosis factor |
decreases expression increases expression multiple interactions |
EXP ISO |
Metformin results in decreased expression of TNF mRNA Metformin results in increased expression of TNF mRNA; Metformin results in increased expression of TNF protein [Paclitaxel co-treated with Metformin] results in decreased expression of TNF mRNA; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 mRNA]; Metformin inhibits the reaction [TNF protein results in increased expression of ABCB1 protein] dorsomorphin inhibits the reaction [Metformin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF mRNA]; Metformin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in increased expression of TNF protein]; Metformin inhibits the reaction [AGT protein results in increased secretion of TNF protein]; Metformin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; Metformin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF protein]; Metformin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Metformin inhibits the reaction [Olanzapine results in increased expression of TNF protein]; Metformin inhibits the reaction [Rotenone results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of TNF protein] [Metformin co-treated with Rosiglitazone co-treated with Valsartan co-treated with Ezetimibe] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with Rosiglitazone co-treated with Valsartan] inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; [Metformin co-treated with Rosiglitazone] promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; dapagliflozin promotes the reaction [Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]]; Metformin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Dietary Fats] results in increased expression of TNF protein]; Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Chlorpyrifos results in increased expression of TNF protein]; Metformin inhibits the reaction [Dehydroepiandrosterone results in increased expression of TNF protein]; Metformin inhibits the reaction [Doxorubicin results in increased expression of TNF protein]; Metformin inhibits the reaction [Fructose results in increased expression of TNF protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of and results in increased secretion of TNF protein]; Metformin inhibits the reaction [Isoproterenol results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Methamphetamine results in increased expression of TNF protein]; Metformin inhibits the reaction [Palmitic Acid results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of TNF mRNA]; Metformin inhibits the reaction [Streptozocin results in increased expression of TNF protein]; Metformin promotes the reaction [[Dietary Fats co-treated with Streptozocin] inhibits the reaction [Ovalbumin results in increased expression of TNF protein]] Metformin co-treated with metformin hydrochloride co-treated with N(gamma)-nitro-L-arginine methyl ester inhibits the reaction [pre-eclampsia increases expression of Tnf protein in blood serum] |
CTD RGD |
PMID:16865780 PMID:19022234 PMID:20869956 PMID:21054339 PMID:21457706 PMID:21870829 PMID:24717679 PMID:24842192 PMID:25108154 PMID:26818447 PMID:27634381 PMID:28096963 PMID:28259689 PMID:29309887 PMID:29499335 PMID:29859833 PMID:30551545 PMID:30742852 PMID:32189544 PMID:32652086 PMID:33639173 PMID:35085591 PMID:35448458 PMID:36547818 PMID:37120126 PMID:31203154 More...
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RGD:213230155 |
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tnfaip8 |
TNF alpha induced protein 8 |
increases expression |
EXP |
Metformin results in increased expression of TNFAIP8 mRNA |
CTD |
PMID:25596134 |
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NCBI chr18:43,183,854...43,299,512
Ensembl chr18:43,183,916...43,299,517
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G |
Tnfrsf10b |
TNF receptor superfamily member 10b |
multiple interactions increases expression |
ISO EXP |
[Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF10A mRNA Metformin results in increased expression of TNFRSF10B mRNA |
CTD |
PMID:25596134 PMID:29309887 |
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NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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G |
Tnfrsf1a |
TNF receptor superfamily member 1A |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF1A mRNA |
CTD |
PMID:29309887 |
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NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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G |
Tnfrsf21 |
TNF receptor superfamily member 21 |
increases expression multiple interactions |
EXP ISO |
Metformin results in increased expression of TNFRSF21 mRNA [Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF21 mRNA |
CTD |
PMID:25596134 PMID:29309887 |
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NCBI chr 9:17,879,156...17,954,085
Ensembl chr 9:17,879,156...17,954,085
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G |
Tnfrsf25 |
TNF receptor superfamily member 25 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in increased expression of TNFRSF25 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 5:162,621,669...162,626,341
Ensembl chr 5:162,622,075...162,626,341
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G |
Tnfrsf9 |
TNF receptor superfamily member 9 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF9 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 5:161,381,662...161,408,003
Ensembl chr 5:161,381,662...161,408,000
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G |
Tnfsf12 |
TNF superfamily member 12 |
multiple interactions |
ISO |
Metformin inhibits the reaction [PPARGC1A protein results in decreased expression of TNFSF12 mRNA] |
CTD |
PMID:22117073 |
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NCBI chr10:54,403,870...54,413,213
Ensembl chr10:54,403,870...54,413,213
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G |
Tp53 |
tumor protein p53 |
affects activity multiple interactions decreases expression |
EXP ISO |
Metformin affects the activity of TP53 protein Metformin increases expression and phosphorylation of TP53 protein in epithelial cell of alveolus of lung [Hydrogen Peroxide co-treated with Metformin] results in decreased expression of TP53 protein Metformin results in decreased expression of TP53 protein |
CTD RGD |
PMID:25596134 PMID:29185360 PMID:23632475 |
RGD:150404268 |
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Tp53inp1 |
tumor protein p53 inducible nuclear protein 1 |
increases expression decreases expression |
EXP ISO |
Metformin results in increased expression of TP53INP1 mRNA Metformin results in decreased expression of TP53INP1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:24,253,986...24,272,250
Ensembl chr 5:24,260,568...24,267,968
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G |
Tpcn1 |
two pore segment channel 1 |
decreases expression |
EXP |
Metformin results in decreased expression of TPCN1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:35,972,813...36,029,632
Ensembl chr12:35,972,846...36,029,626
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G |
Tradd |
TNFRSF1A-associated via death domain |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of TRADD mRNA |
CTD |
PMID:29309887 |
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NCBI chr19:33,136,148...33,142,714
Ensembl chr19:33,136,138...33,142,638
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G |
Traf2 |
Tnf receptor-associated factor 2 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of TRAF2 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 3:8,341,950...8,366,609
Ensembl chr 3:8,341,951...8,366,538
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G |
Traf3 |
Tnf receptor-associated factor 3 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of TRAF3 mRNA |
CTD |
PMID:29309887 |
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NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
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G |
Traf4 |
Tnf receptor associated factor 4 |
multiple interactions |
ISO |
[Paclitaxel co-treated with Metformin] results in decreased expression of TRAF4 mRNA |
CTD |
PMID:29309887 |
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NCBI chr10:63,054,169...63,060,284
Ensembl chr10:63,054,181...63,060,284
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G |
Trafd1 |
TRAF type zinc finger domain containing 1 |
decreases expression |
EXP |
Metformin results in decreased expression of TRAFD1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr12:35,165,606...35,179,525
Ensembl chr12:35,165,606...35,179,525
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G |
Trim21 |
tripartite motif-containing 21 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of TRIM21 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440
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G |
Trim39 |
tripartite motif-containing 39 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TRIM39 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr20:2,003,320...2,017,175
Ensembl chr20:1,983,533...2,020,117
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G |
Trpc1 |
transient receptor potential cation channel, subfamily C, member 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of TRPC1 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276
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G |
Tsku |
tsukushi, small leucine rich proteoglycan |
affects expression |
EXP |
Metformin affects the expression of TSKU mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:152,660,259...152,671,682
Ensembl chr 1:152,656,693...152,672,588
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G |
Tspan12 |
tetraspanin 12 |
decreases expression |
EXP |
Metformin results in decreased expression of TSPAN12 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 4:50,313,768...50,389,246
Ensembl chr 4:50,313,772...50,389,246
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G |
Txnip |
thioredoxin interacting protein |
multiple interactions |
ISO |
Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]]; Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein] Metformin inhibits the reaction [Glucose results in increased expression of TXNIP mRNA] |
CTD |
PMID:29426000 PMID:31974165 |
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NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
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G |
Txnrd1 |
thioredoxin reductase 1 |
increases expression |
EXP |
Metformin results in increased expression of TXNRD1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 7:20,830,042...20,914,990
Ensembl chr 7:20,830,045...20,907,863
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G |
Uap1l1 |
UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of UAP1L1 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr 3:8,172,335...8,180,505
Ensembl chr 3:8,173,216...8,180,443
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G |
Ube2b |
ubiquitin-conjugating enzyme E2B |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of UBE2B mRNA] |
CTD |
PMID:29095437 |
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NCBI chr10:36,248,434...36,263,379
Ensembl chr10:36,248,438...36,264,665
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G |
Ube2g2 |
ubiquitin-conjugating enzyme E2G 2 |
decreases expression |
EXP |
Metformin results in decreased expression of UBE2G2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr20:10,983,734...11,005,468
Ensembl chr20:10,983,742...11,005,447
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G |
Ucp2 |
uncoupling protein 2 |
increases expression |
ISO |
Metformin results in increased expression of UCP2 mRNA; Metformin results in increased expression of UCP2 protein |
CTD |
PMID:22815988 PMID:34302933 |
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NCBI chr 1:154,839,242...154,845,612
Ensembl chr 1:154,839,209...154,845,611
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G |
Ugt2a3 |
UDP glucuronosyltransferase family 2 member A3 |
increases expression |
EXP |
Metformin results in increased expression of UGT2A3 mRNA |
CTD |
PMID:31324951 |
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NCBI chr14:20,572,793...20,590,795
Ensembl chr14:20,572,808...20,590,729
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G |
Ulk1 |
unc-51 like autophagy activating kinase 1 |
increases expression multiple interactions |
ISO |
Metformin results in increased expression of ULK1 mRNA [Metformin co-treated with Pioglitazone] results in increased expression of ULK1 mRNA |
CTD |
PMID:32589349 |
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NCBI chr12:45,851,710...45,877,966
Ensembl chr12:45,851,710...45,877,966
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G |
Ulk2 |
unc-51 like autophagy activating kinase 2 |
increases expression |
ISO |
Metformin results in increased expression of ULK2 mRNA |
CTD |
PMID:32589349 |
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NCBI chr10:46,451,578...46,530,462
Ensembl chr10:46,454,030...46,530,407
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G |
Unkl |
unk like zinc finger |
decreases expression |
EXP |
Metformin results in decreased expression of UNKL mRNA |
CTD |
PMID:25596134 |
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NCBI chr10:14,206,125...14,252,226
Ensembl chr10:14,206,189...14,252,225
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G |
Usp3 |
ubiquitin specific peptidase 3 |
increases expression |
EXP |
Metformin results in increased expression of USP3 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 8:67,078,249...67,154,109
Ensembl chr 8:67,079,927...67,154,111
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G |
Vars1 |
valyl-tRNA synthetase 1 |
increases expression |
EXP |
Metformin results in increased expression of VARS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr20:3,805,774...3,820,468
Ensembl chr20:3,805,776...3,820,298
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
Metformin results in decreased expression of VEGFA mRNA |
CTD |
PMID:23653852 |
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NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Vegfb |
vascular endothelial growth factor B |
increases expression |
EXP |
Metformin results in increased expression of VEGFB mRNA |
CTD |
PMID:25596134 |
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NCBI chr 1:204,172,297...204,178,046
Ensembl chr 1:204,172,225...204,177,944
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G |
Vgll4 |
vestigial-like family member 4 |
decreases expression |
EXP |
Metformin results in decreased expression of VGLL4 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 4:147,925,630...148,038,519
Ensembl chr 4:147,927,034...148,038,471
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G |
Vim |
vimentin |
decreases expression multiple interactions |
ISO |
Metformin results in decreased expression of VIM protein Metformin inhibits the reaction [BMP2 protein results in increased expression of VIM mRNA] |
CTD |
PMID:35248696 PMID:37409753 |
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NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Vnn1 |
vanin 1 |
multiple interactions |
EXP |
Metformin inhibits the reaction [[Streptozocin co-treated with Fructose] results in increased expression of VNN1 mRNA] |
CTD |
PMID:30551545 |
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NCBI chr 1:21,537,084...21,547,395
Ensembl chr 1:21,537,094...21,547,395
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G |
Vps53 |
VPS53 subunit of GARP complex |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in increased expression of VPS53 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr10:60,919,820...61,038,674
Ensembl chr10:60,919,820...61,038,676
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G |
Vsnl1 |
visinin-like 1 |
decreases expression |
EXP |
Metformin results in decreased expression of VSNL1 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479
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G |
Wars1 |
tryptophanyl-tRNA synthetase 1 |
increases expression |
EXP |
Metformin results in increased expression of WARS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 6:127,776,088...127,807,273
Ensembl chr 6:127,776,090...127,807,269
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G |
Wwc2 |
WW and C2 domain containing 2 |
increases expression |
EXP |
Metformin results in increased expression of WWC2 mRNA |
CTD |
PMID:25596134 |
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NCBI chr16:44,258,372...44,421,815
Ensembl chr16:44,258,372...44,421,812
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G |
Xbp1 |
X-box binding protein 1 |
affects activity affects expression multiple interactions |
EXP ISO |
Metformin affects the activity of XBP1 protein Metformin affects the expression of XBP1 mRNA [Paclitaxel co-treated with Metformin] results in decreased expression of XBP1 mRNA; Metformin inhibits the reaction [INS protein results in increased expression of XBP1 protein] Metformin inhibits the reaction [Rotenone results in increased expression of XBP1 mRNA] Metformin inhibits the reaction [Glucose results in increased expression of XBP1 mRNA] |
CTD |
PMID:25596134 PMID:29309887 PMID:32189544 PMID:34801538 PMID:36764371 |
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NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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G |
Xpc |
XPC complex subunit, DNA damage recognition and repair factor |
decreases expression increases expression |
EXP |
Metformin results in decreased expression of XPC mRNA Metformin results in increased expression of XPC mRNA |
CTD |
PMID:25596134 PMID:31324951 |
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NCBI chr 4:123,993,670...124,020,922
Ensembl chr 4:123,993,666...124,021,010
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G |
Xrcc1 |
X-ray repair cross complementing 1 |
decreases activity multiple interactions |
ISO |
Metformin results in decreased activity of XRCC1 protein [Metformin co-treated with Hydrogen Peroxide] results in decreased activity of XRCC1 protein |
CTD |
PMID:29185360 |
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NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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G |
Yars1 |
tyrosyl-tRNA synthetase 1 |
increases expression |
EXP |
Metformin results in increased expression of YARS1 mRNA |
CTD |
PMID:25596134 |
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NCBI chr 5:141,535,815...141,564,029
Ensembl chr 5:141,535,759...141,563,833
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G |
Ypel2 |
yippee-like 2 |
decreases expression |
EXP |
Metformin results in decreased expression of YPEL2 mRNA |
CTD |
PMID:31324951 |
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NCBI chr10:71,746,308...71,803,843
Ensembl chr10:71,746,311...71,803,911
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G |
Zbtb16 |
zinc finger and BTB domain containing 16 |
increases expression |
EXP |
Metformin results in increased expression of ZBTB16 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 8:48,989,376...49,177,011
Ensembl chr 8:48,994,566...49,177,011
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G |
Zbtb21 |
zinc finger and BTB domain containing 21 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Arsenic Trioxide results in decreased expression of ZBTB21 mRNA] |
CTD |
PMID:29095437 |
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NCBI chr11:37,312,337...37,327,040
Ensembl chr11:37,312,378...37,326,996
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G |
Zfp239 |
zinc finger protein 239 |
increases expression |
ISO |
Metformin results in increased expression of ZFP239 mRNA |
CTD |
PMID:23457588 |
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NCBI chr 4:151,029,431...151,039,283
Ensembl chr 4:151,029,405...151,039,529
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G |
Zfp354a |
zinc finger protein 354A |
increases expression |
EXP |
Metformin results in increased expression of ZFP354A mRNA |
CTD |
PMID:31324951 |
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NCBI chr10:35,396,242...35,408,069
Ensembl chr10:35,396,231...35,408,068
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G |
Zfp36 |
zinc finger protein 36 |
decreases expression |
EXP |
Metformin results in decreased expression of ZFP36 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 1:83,669,084...83,671,564
Ensembl chr 1:83,669,084...83,671,564
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G |
Zfp46 |
zinc finger protein 46 |
increases expression |
EXP |
Metformin results in increased expression of ZFP46 mRNA |
CTD |
PMID:31324951 |
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NCBI chr 5:148,519,398...148,529,903
Ensembl chr 5:148,520,855...148,529,459
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G |
Zfp57 |
zinc finger protein 57 |
multiple interactions |
ISO |
Metformin inhibits the reaction [Dietary Fats results in increased expression of ZFP57 protein] |
CTD |
PMID:36375515 |
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NCBI chr20:1,521,323...1,534,884
Ensembl chr20:1,521,323...1,529,846
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G |
Zfp791 |
zinc finger protein 791 |
decreases expression |
ISO |
Metformin results in decreased expression of ZFP791 mRNA |
CTD |
PMID:23457588 |
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NCBI chr19:23,018,418...23,033,580
Ensembl chr19:23,018,918...23,033,504
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