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Gene: Iars1 (isoleucyl-tRNA synthetase 1) Rattus norvegicus
Symbol: Iars1
Name: isoleucyl-tRNA synthetase 1
RGD ID: 621022
Description: Predicted to have GTPase binding activity and isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation. Predicted to localize to aminoacyl-tRNA synthetase multienzyme complex and cytosol. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1); PARTICIPATES IN aminoacyl-tRNA biosynthetic pathway; valine, leucine and isoleucine biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Iars; Iarsl; isoleucine tRNA synthetase; isoleucine--tRNA ligase, cytoplasmic; isoleucine-tRNA synthetase; isoleucine-tRNA synthetase-like; isoleucyl tRNA synthetase; isoleucyl-tRNA synthetase; isoleucyl-tRNA synthetase, cytoplasmic; LOC306804
Homo sapiens (human) : IARS1 (isoleucyl-tRNA synthetase 1)  HGNC  Alliance
Mus musculus (house mouse) : Iars (isoleucine-tRNA synthetase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Iars1 (isoleucyl-tRNA synthetase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : IARS1 (isoleucyl-tRNA synthetase 1)
Canis lupus familiaris (dog) : IARS1 (isoleucyl-tRNA synthetase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Iars1 (isoleucyl-tRNA synthetase 1)
Sus scrofa (pig) : IARS1 (isoleucyl-tRNA synthetase 1)
Chlorocebus sabaeus (African green monkey) : IARS1 (isoleucyl-tRNA synthetase 1)
Heterocephalus glaber (naked mole-rat) : Iars1 (isoleucyl-tRNA synthetase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01715,356,016 - 15,402,680 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1715,355,529 - 15,402,649 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01716,604,188 - 16,614,960 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01717,414,466 - 17,461,119 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41720,895,852 - 20,942,180 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11720,895,861 - 20,937,378 (-)NCBI
Celera1714,672,657 - 14,718,804 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Iars1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621022
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.