naphthopyran - Ontology Report - Rat Genome Database

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	naphthopyran	go back to main search page
Accession:	CHEBI:86027	browse the term
Definition:	Any organic heterotricyclic compound with a skeleton consisting of a pyran ring ortho-fused to a naphthalene.
Synonyms:	related_synonym:	naphthopyrans

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Genes (1216)

alpha-naphthoflavone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ADAM metallopeptidase with thrombospondin type 1 motif, 1

multiple interactions

[alpha-naphthoflavone co-treated with Methylcholanthrene] results in decreased acetylation of ADAMTS1 promoter; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of ADAMTS1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ADAMTS1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of ADAMTS1 promoter]

NCBI chr11:24,932,227...24,941,068
Ensembl chr11:24,931,761...24,941,103

G

aryl hydrocarbon receptor

affects binding
decreases activity
multiple interactions

[alpha-naphthoflavone binds to AHR protein] which binds to ESR1 protein; [alpha-naphthoflavone binds to AHR protein] which binds to ESRRA protein; [alpha-naphthoflavone binds to AHR protein] which binds to NR2F1 protein; alpha-naphthoflavone binds to AHR protein
alpha-naphthoflavone results in decreased activity of AHR protein
[alpha-naphthoflavone results in decreased activity of AHR protein] which results in decreased expression of CYP1A1 mRNA; AHR gene mutant form inhibits the reaction [alpha-naphthoflavone results in increased expression of IGFBP4 protein]; AHR protein promotes the reaction [alpha-naphthoflavone results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone binds to and results in decreased activity of AHR protein; alpha-naphthoflavone binds to and results in increased activity of AHR protein; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [hydroquinone results in increased expression of AHR protein]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of and results in increased activity of AHR protein]; alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of AHR mRNA]
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IL10 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] results in decreased susceptibility to [SB 203580 results in increased expression of CYP1A1]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Benzo(a)pyrene; alpha-naphthoflavone binds to and results in decreased activity of AHR protein; alpha-naphthoflavone binds to and results in increased activity of AHR protein; alpha-naphthoflavone inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of and results in increased activity of AHR protein]
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG mRNA]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] which results in decreased susceptibility to Hexachlorobenzene; [alpha-naphthoflavone results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased abundance of Reactive Oxygen Species]; alpha-naphthoflavone analog inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone analog results in increased activity of [AHR protein binds to ARNT protein]; alpha-naphthoflavone binds to and results in decreased activity of AHR protein; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[benzo(k)fluoranthene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[chrysene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Oxygen deficiency co-treated with Tetrachlorodibenzodioxin] results in decreased stability of AHR protein]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein]; alpha-naphthoflavone inhibits the reaction [AHR promotes the reaction [Tetrachlorodibenzodioxin results in decreased uptake of Glucose]]; alpha-naphthoflavone inhibits the reaction [AHR protein binds to and results in increased metabolism of Benzo(a)pyrene]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of AHR protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of and results in increased activity of AHR protein]; alpha-naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]

PMID:1329656 PMID:7669069 PMID:8390116 PMID:8738555 PMID:9006915 More...

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

AKT serine/threonine kinase 1

multiple interactions
increases methylation

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of AKT1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of AKT1 mRNA]
alpha-naphthoflavone results in increased methylation of AKT1 promoter

NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921

G

androgen receptor

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of AR protein]; alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]; bicalutamide inhibits the reaction [alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]]; bicalutamide inhibits the reaction [alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Dihydrotestosterone results in increased activity of AR protein]]]
alpha-naphthoflavone results in increased expression of AR protein

PMID:12970580 PMID:15041469

NCBI chr X:63,104,771...63,273,934
Ensembl chr X:63,104,771...63,273,925

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

alpha-naphthoflavone analog results in increased activity of [AHR protein binds to ARNT protein]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]
ARNT protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]

PMID:11768231 PMID:21127131 PMID:30508555

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

BCL2 associated X, apoptosis regulator

multiple interactions

alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in increased expression of BAX mRNA]
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to BAX promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of BAX mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of BAX promoter]

PMID:20562217 PMID:29094188

NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368

G

bone morphogenetic protein 15

multiple interactions

[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of BMP15 mRNA

NCBI chr X:16,169,123...16,174,187
Ensembl chr X:16,169,123...16,174,187

G

bisphosphoglycerate mutase

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of BPGM mRNA]
alpha-naphthoflavone results in increased expression of BPGM mRNA

NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581

G

BRCA1, DNA repair associated

multiple interactions

alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased activity of BRCA1 protein]; alpha-naphthoflavone inhibits the reaction [Estradiol results in increased expression of BRCA1 mRNA]

PMID:16489025 PMID:18259752

NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304

G

calreticulin

multiple interactions

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CALR mRNA]

NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414

G

caspase 12

increases cleavage

alpha-naphthoflavone results in increased cleavage of CASP12 protein

NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037

G

caspase 3

increases activity
multiple interactions
increases cleavage
decreases activity

alpha-naphthoflavone results in increased activity of CASP3 protein
alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased cleavage of CASP3 protein]
alpha-naphthoflavone results in increased cleavage of CASP3 protein
alpha-naphthoflavone results in decreased activity of CASP3 protein

PMID:15710172 PMID:18334599 PMID:30508555 PMID:35908932

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caspase 8

increases activity

alpha-naphthoflavone results in increased activity of CASP8 protein

NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542

G

caspase 9

increases activity
multiple interactions

alpha-naphthoflavone results in increased activity of CASP9 protein
[alpha-naphthoflavone co-treated with Methylcholanthrene] results in decreased acetylation of CASP9 promoter; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CASP9 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CASP9 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of CASP9 promoter]

PMID:18334599 PMID:29094188

NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626

G

catalase

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased activity of CAT protein]

NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478

G

C-C motif chemokine ligand 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CCL1]

NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159

G

C-C motif chemokine ligand 2

decreases expression
increases expression
multiple interactions

alpha-naphthoflavone results in decreased expression of CCL2 mRNA
alpha-naphthoflavone results in increased expression of CCL2 mRNA
alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CCL2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCL2 mRNA]

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

cyclin B1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Plant Extracts results in decreased expression of CCNB1 mRNA]

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin D1

multiple interactions

alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of CCND1 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of CCND1 protein]

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

CD9 molecule

multiple interactions

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of CD9 mRNA]

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222

G

cell division cycle 25C

multiple interactions

alpha-naphthoflavone inhibits the reaction [Plant Extracts results in decreased expression of CDC25C mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDC25C protein]

PMID:22266097 PMID:25051199

NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185

G

cadherin 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in decreased expression of CDH1 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in decreased expression of CDH1 protein]

NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775

G

cadherin 13

multiple interactions

AHR protein promotes the reaction [alpha-naphthoflavone results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of CDH13 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDH13 mRNA]

NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459

G

cyclin-dependent kinase 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of CDK1 protein]

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin dependent kinase 2

multiple interactions
decreases methylation

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to CDK2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased methylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of CDK2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CDK2 mRNA]
alpha-naphthoflavone results in decreased methylation of CDK2 promoter

NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403

G

cyclin-dependent kinase inhibitor 1A

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene promotes the reaction [eupatorin-5-methyl ether results in increased expression of CDKN1A protein]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CDKN1A mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A protein]

PMID:21887816 PMID:22266097 PMID:23994263 PMID:24361490

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1B

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1B protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDKN1B protein]

PMID:15157999 PMID:22266097

NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982

G

CCAAT/enhancer binding protein delta

multiple interactions

alpha-naphthoflavone promotes the reaction [Particulate Matter results in increased expression of CEBPD mRNA]

NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829

G

colony stimulating factor 2

multiple interactions

alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of CSF2 mRNA]

NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199

G

cathepsin D

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of CTSD mRNA]]

NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488

G

cytoglobin

multiple interactions

alpha-naphthoflavone inhibits the reaction [2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole results in increased expression of CYGB mRNA]

NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442

G

cytochrome P450, family 11, subfamily b, polypeptide 2

multiple interactions
increases expression

alpha-naphthoflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]
alpha-naphthoflavone results in increased expression of CYP11B1 mRNA

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 17, subfamily a, polypeptide 1

decreases expression

alpha-naphthoflavone results in decreased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

multiple interactions
increases expression

[alpha-naphthoflavone results in decreased activity of CYP19A1 protein] which results in decreased susceptibility to o,p'-DDT; alpha-naphthoflavone binds to and results in decreased activity of CYP19A1 protein; alpha-naphthoflavone inhibits the reaction [Aflatoxin B1 results in increased expression of CYP19A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CYP19A1 protein]
alpha-naphthoflavone results in increased expression of CYP19A1 protein

PMID:9435150 PMID:20678559 PMID:20823264 PMID:21296134

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

increases activity
affects binding
increases expression
multiple interactions
decreases activity

alpha-naphthoflavone results in increased activity of CYP1A1 protein
CYP1A1 protein binds to alpha-naphthoflavone
alpha-naphthoflavone results in increased expression of CYP1A1 mRNA
alpha-naphthoflavone analog results in increased expression of CYP1A1 mRNA; alpha-naphthoflavone results in increased expression of CYP1A1 mRNA; alpha-naphthoflavone results in increased expression of CYP1A1 protein
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [[3,4,5,3',4'-pentachlorobiphenyl co-treated with Benzo(a)pyrene] results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which binds to CYP1A1 enhancer]; alpha-naphthoflavone inhibits the reaction [[AHR protein binds to ARNT protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[benzo(k)fluoranthene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[chrysene binds to and results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] which results in increased metabolism of Benzo(a)pyrene]; alpha-naphthoflavone inhibits the reaction [afimoxifene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Calcitriol promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; alpha-naphthoflavone inhibits the reaction [Carbaryl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Cycloheximide results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Resveratrol results in increased expression of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [STO 609 results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
alpha-naphthoflavone results in decreased activity of CYP1A1 protein
[alpha-naphthoflavone results in decreased activity of AHR protein] which results in decreased expression of CYP1A1 mRNA; [alpha-naphthoflavone results in decreased activity of CYP1A1 protein] inhibits the reaction [Vinyl Compounds analog results in decreased susceptibility to sodium arsenite]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin results in increased activity of AHR protein] which results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of CYP1A1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of CYP1A1 promoter]; alpha-naphthoflavone inhibits the reaction [norisoboldine results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]; alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]
[[alpha-naphthoflavone results in decreased activity of CYP1A2 protein] co-treated with [alpha-naphthoflavone results in decreased activity of CYP1A1 protein]] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] results in decreased susceptibility to [SB 203580 results in increased expression of CYP1A1]; alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA]; SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA]
alpha-naphthoflavone analog results in increased activity of CYP1A1 protein

PMID:1329656 PMID:6477826 PMID:7669069 PMID:8390116 PMID:8637871 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions
affects binding
increases expression
increases metabolic processing
affects metabolic processing
decreases activity

[alpha-naphthoflavone results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Phenacetin; alpha-naphthoflavone binds to and results in decreased activity of CYP1A2 protein; alpha-naphthoflavone inhibits the reaction [2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of CYP1A2 mRNA]; alpha-naphthoflavone inhibits the reaction [2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in increased expression of CYP1A2 mRNA]; alpha-naphthoflavone inhibits the reaction [CYP1A2 protein results in increased metabolism of Triazines]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
CYP1A2 protein binds to alpha-naphthoflavone
alpha-naphthoflavone results in increased expression of CYP1A2 protein
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with alpha-naphthoflavone] results in increased expression of CYP1A2 protein; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]
[[alpha-naphthoflavone results in decreased activity of CYP1A2 protein] co-treated with [alpha-naphthoflavone results in decreased activity of CYP1A1 protein]] inhibits the reaction [aristolochic acid I results in increased abundance of [7-(deoxyadenosin-N(6)-yl)aristolactam I co-treated with 7-(deoxyguanosin-N(2)-yl)aristolactam I co-treated with 7-(deoxyadenosin-N(6)--yl)aristolactam II]]; [alpha-naphthoflavone results in decreased activity of CYP1A2 protein] which results in decreased reduction of and results in decreased oxidation of 9-anthraldehyde
CYP1A2 protein results in increased metabolism of alpha-naphthoflavone
alpha-naphthoflavone results in increased expression of CYP1A2 mRNA; alpha-naphthoflavone results in increased expression of CYP1A2 protein
CYP1A2 protein affects the metabolism of alpha-naphthoflavone

PMID:2180560 PMID:9305587 PMID:15306208 PMID:15766918 PMID:15860655 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
affects binding
increases metabolic processing
increases expression
decreases expression
decreases activity

alpha-naphthoflavone binds to and results in decreased activity of CYP1B1 protein; alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of CYP1B1 mRNA]; alpha-naphthoflavone inhibits the reaction [6-formylindolo(3,2-b)carbazole results in increased expression of CYP1B1 mRNA]; alpha-naphthoflavone inhibits the reaction [[CYP1B1 protein co-treated with NADP] results in increased metabolism of 2,4,3',5'-tetramethoxystilbene]; alpha-naphthoflavone inhibits the reaction [[CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene] which results in increased expression of TP53 protein modified form]; alpha-naphthoflavone inhibits the reaction [CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1B1 mRNA]
CYP1B1 protein binds to alpha-naphthoflavone
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of CYP1B1 mRNA]
CYP1B1 protein results in increased metabolism of alpha-naphthoflavone
alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP1B1 protein]; alpha-naphthoflavone inhibits the reaction [AHR protein promotes the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]]
alpha-naphthoflavone results in increased expression of CYP1B1 mRNA
alpha-naphthoflavone results in decreased expression of CYP1B1 mRNA
alpha-naphthoflavone results in decreased activity of CYP1B1 protein

PMID:11577022 PMID:15075337 PMID:15280921 PMID:16120791 PMID:19182260 More...

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 24, subfamily a, polypeptide 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]; alpha-naphthoflavone inhibits the reaction [Cycloheximide promotes the reaction [Calcitriol results in increased expression of CYP24A1 mRNA]]

NCBI chr 3:159,275,947...159,290,383
Ensembl chr 3:159,275,947...159,290,383

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP2C11 mRNA]

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily f, polypeptide 4

multiple interactions

[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA]

NCBI chr 1:82,416,107...82,429,897
Ensembl chr 1:82,416,130...82,429,896

G

cytochrome P450, family 2, subfamily j, polypeptide 4

decreases activity

alpha-naphthoflavone results in decreased activity of CYP2J2 protein

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 3, subfamily a, polypeptide 2

decreases activity
multiple interactions
affects binding
increases activity

alpha-naphthoflavone results in decreased activity of CYP3A4 protein
[[alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [alpha-naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; alpha-naphthoflavone binds to and results in decreased activity of CYP3A4 protein; alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased hydrolysis of Testosterone]; alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of 7-benzyloxy-4-trifluoromethylcoumarin]; alpha-naphthoflavone inhibits the reaction [CYP3A4 protein results in increased oxidation of Methylenebis(chloroaniline)]
alpha-naphthoflavone binds to CYP3A4 protein

PMID:1740010 PMID:2271712 PMID:15005856 PMID:17198380 PMID:19299527 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

deleted in azoospermia-like

multiple interactions

alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DAZL mRNA]

NCBI chr 9:10,695,593...10,712,330
Ensembl chr 9:10,695,592...10,712,323

G

DNA-damage inducible transcript 3

increases expression
multiple interactions

alpha-naphthoflavone results in increased expression of DDIT3 protein
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; ARNT protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; pyrazolanthrone inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; salubrinal inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; SB 203580 inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]; SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]

NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201

G

discoidin domain receptor tyrosine kinase 2

multiple interactions

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDR2 mRNA]

NCBI chr13:82,193,623...82,318,229
Ensembl chr13:82,195,463...82,317,363

G

DEAD-box helicase 4

multiple interactions

alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of DDX4 mRNA]

NCBI chr 2:44,227,946...44,282,867
Ensembl chr 2:44,227,946...44,282,723

G

DEAD-box helicase 5

multiple interactions

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DDX5 mRNA]

NCBI chr10:91,723,508...91,732,210
Ensembl chr10:91,723,508...91,732,283

G

delta like canonical Notch ligand 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DLL1 mRNA]

NCBI chr 1:56,312,062...56,320,177
Ensembl chr 1:56,312,066...56,320,179

G

DnaJ heat shock protein family (Hsp40) member B6

decreases methylation
multiple interactions

alpha-naphthoflavone results in decreased methylation of DNAJB6 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to DNAJB6 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of DNAJB6 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of DNAJB6 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of DNAJB6 promoter]

NCBI chr 4:5,452,683...5,556,679
Ensembl chr 4:5,452,683...5,556,659

G

dual specificity phosphatase 5

multiple interactions

alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 protein]

NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818

G

epidermal growth factor receptor

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of and results in increased activity of EGFR protein]

NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382

G

egl-9 family hypoxia-inducible factor 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of EGLN1 protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of EGLN1 mRNA]

NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777

G

eukaryotic translation initiation factor 2 subunit alpha

increases phosphorylation

alpha-naphthoflavone results in increased phosphorylation of EIF2S1 protein

NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225

G

enolase 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of ENO1 mRNA]

NCBI chr 5:160,719,951...160,731,337
Ensembl chr 5:160,719,951...160,731,336

G

ectonucleotide pyrophosphatase/phosphodiesterase 2

multiple interactions

alpha-naphthoflavone inhibits the reaction [Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]

NCBI chr 7:86,202,345...86,325,050
Ensembl chr 7:86,202,350...86,324,827

G

endogenous retrovirus group FRD member 1, envelope

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of ERVFRD-1 mRNA]

NCBI chr12:22,151,211...22,158,264
Ensembl chr12:22,151,211...22,158,264

G

estrogen receptor 1

affects binding
multiple interactions

[alpha-naphthoflavone binds to AHR protein] which binds to ESR1 protein
alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Estradiol binds to ESR1 protein]]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of ESR1 protein]; alpha-naphthoflavone inhibits the reaction [Particulate Matter analog inhibits the reaction [Estradiol binds to ESR1 protein]]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions analog inhibits the reaction [Estradiol binds to ESR1 protein]]
[alpha-naphthoflavone co-treated with beta-Naphthoflavone] results in decreased expression of ESR1 mRNA; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ESR1 mRNA]

PMID:10620335 PMID:15253042 PMID:22975028 PMID:29094188 PMID:35181438

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

[alpha-naphthoflavone co-treated with beta-Naphthoflavone] results in decreased expression of ESR2 mRNA

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

estrogen related receptor, alpha

affects binding

[alpha-naphthoflavone binds to AHR protein] which binds to ESRRA protein

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

Fas cell surface death receptor

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FAS mRNA]

NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591

G

Fas ligand

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FASL mRNA]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fibroblast growth factor 2

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]

NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221

G

filaggrin

multiple interactions

[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of FLG mRNA]

NCBI chr 2:178,884,793...178,912,986

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Estradiol results in increased expression of FOS mRNA]]

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

forkhead box N3

multiple interactions

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of FOXN3 mRNA]

NCBI chr 6:118,462,018...118,842,442
Ensembl chr 6:118,466,025...118,842,401

G

forkhead box O3

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of FOXO3 protein]
[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of FOXO3 mRNA

PMID:22266097 PMID:29094188

NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561

G

forkhead box P3

multiple interactions

alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of FOXP3 mRNA]

NCBI chr X:14,908,494...14,924,994
Ensembl chr X:14,908,494...14,923,838

G

follicle stimulating hormone receptor

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of FSHR protein]

NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785

G

growth differentiation factor 9

increases expression
multiple interactions

alpha-naphthoflavone results in increased expression of GDF9 mRNA
[Methylcholanthrene co-treated with alpha-naphthoflavone] results in increased expression of GDF9 mRNA

NCBI chr10:37,589,200...37,599,970
Ensembl chr10:37,595,679...37,599,672

G

glucose-6-phosphate isomerase

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GPI mRNA]
alpha-naphthoflavone results in increased expression of GPI mRNA

NCBI chr 1:86,828,211...86,856,077
Ensembl chr 1:86,828,216...86,856,086

G

glutathione-disulfide reductase

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of GSR mRNA]

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase pi 1

decreases expression

alpha-naphthoflavone results in decreased expression of GSTP1 mRNA

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

hes family bHLH transcription factor 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to HES1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of HES1 mRNA]

NCBI chr11:70,705,763...70,708,176
Ensembl chr11:70,705,764...70,708,192

G

hexokinase 1

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of HK1 mRNA]
alpha-naphthoflavone results in increased expression of HK1 mRNA

NCBI chr20:30,230,488...30,332,099
Ensembl chr20:30,230,486...30,332,131

G

3-hydroxy-3-methylglutaryl-CoA reductase

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of HMGCR protein]

NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703

G

heat shock protein family A (Hsp70) member 8

multiple interactions

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of HSPA8 mRNA]

NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259

G

intercellular adhesion molecule 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of ICAM1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to ICAM1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of ICAM1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of ICAM1 mRNA]

PMID:26519956 PMID:29094188

NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438

G

insulin-like growth factor 2

decreases acetylation
multiple interactions

alpha-naphthoflavone results in decreased acetylation of IGF2 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to IGF2 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of IGF2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IGF2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of IGF2 promoter]

NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018

G

insulin-like growth factor binding protein 4

multiple interactions
increases expression

AHR gene mutant form inhibits the reaction [alpha-naphthoflavone results in increased expression of IGFBP4 protein]

NCBI chr10:83,995,253...84,007,272
Ensembl chr10:83,989,591...84,007,225

G

interleukin 10

multiple interactions

alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene co-treated with Lipopolysaccharides] affects the expression of IL10 mRNA]; alpha-naphthoflavone inhibits the reaction [[Benzo(a)pyrene co-treated with Lipopolysaccharides] affects the expression of IL10 protein]
[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of IL10 protein]; alpha-naphthoflavone inhibits the reaction [tetrandrine results in increased expression of IL10 mRNA]

PMID:11737050 PMID:17681673 PMID:26640276

NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313

G

interleukin 1 beta

multiple interactions
increases expression
decreases expression

alpha-naphthoflavone analog inhibits the reaction [IL1B protein results in increased expression of SAA1 mRNA]; alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1B protein]
alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of IL1B mRNA]
alpha-naphthoflavone results in increased expression of IL1B mRNA
alpha-naphthoflavone results in decreased expression of IL1B mRNA

PMID:14993811 PMID:15019843 PMID:18617548 PMID:21127131 PMID:22262711 More...

NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415

G

interleukin 1 receptor antagonist

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of IL1RN mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1RN mRNA]
alpha-naphthoflavone results in increased expression of IL1RN mRNA

NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445

G

interleukin 6

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions results in increased expression of IL6 mRNA]
alpha-naphthoflavone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased expression of IL6 mRNA]
alpha-naphthoflavone results in increased expression of IL6 mRNA

PMID:21162728 PMID:26519956

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

integrin subunit beta 8

multiple interactions

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased expression of ITGB8 mRNA]

NCBI chr 6:140,125,002...140,208,261
Ensembl chr 6:140,127,203...140,208,476

G

jagged canonical Notch ligand 1

decreases methylation
multiple interactions

alpha-naphthoflavone results in decreased methylation of JAG1 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to JAG1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of JAG1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of JAG1 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of JAG1 promoter]

NCBI chr 3:124,406,783...124,442,220
Ensembl chr 3:124,406,794...124,442,209

G

Jun proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of JUN protein]
alpha-naphthoflavone results in increased expression of JUN mRNA

PMID:15019843 PMID:15897893

NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656

G

kallikrein 1-related peptidase C10

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]]; alpha-naphthoflavone inhibits the reaction [benzo(k)fluoranthene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]; alpha-naphthoflavone inhibits the reaction [benzo(k)fluoranthene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]]; alpha-naphthoflavone inhibits the reaction [chrysene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 mRNA]]; alpha-naphthoflavone inhibits the reaction [chrysene inhibits the reaction [Dihydrotestosterone results in increased expression of KLK3 protein]]

NCBI chr 1:94,402,993...94,407,052
Ensembl chr 1:94,402,993...94,407,052

G

keratin 14

multiple interactions

alpha-naphthoflavone inhibits the reaction [Plant Extracts results in decreased expression of KRT14 mRNA]

NCBI chr10:85,137,786...85,142,054
Ensembl chr10:85,066,802...85,171,799

G

lactate dehydrogenase A

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of LDHA mRNA]
alpha-naphthoflavone results in increased expression of LDHA mRNA

NCBI chr 1:97,371,823...97,381,247
Ensembl chr 1:97,366,021...97,433,472

G

luteinizing hormone/choriogonadotropin receptor

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of LHCGR protein]

NCBI chr 6:5,661,871...5,728,109
Ensembl chr 6:5,661,871...5,724,521

G

mitogen activated protein kinase 1

multiple interactions
increases phosphorylation

[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK1 protein]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK1 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK1 protein]]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK1 protein]
alpha-naphthoflavone results in increased phosphorylation of MAPK1 protein
SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased phosphorylation of MAPK1 protein]

PMID:19578757 PMID:20876236 PMID:21205633 PMID:26358519 PMID:30508555

NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616

G

mitogen activated protein kinase 3

multiple interactions
increases phosphorylation

[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of MAPK3 protein]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in increased phosphorylation of MAPK3 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [FGF2 protein results in increased phosphorylation of MAPK3 protein]]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of MAPK3 protein]
SU 6656 inhibits the reaction [alpha-naphthoflavone results in increased phosphorylation of MAPK3 protein]

PMID:19578757 PMID:20876236 PMID:21205633 PMID:26358519 PMID:30508555

NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863

G

MDM2 proto-oncogene

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [Oxygen deficiency results in increased expression of MDM2 mRNA]]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MDM2 mRNA]

NCBI chr 7:53,290,660...53,315,205
Ensembl chr 7:53,290,664...53,314,915

G

matrix metallopeptidase 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP1 mRNA]
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA]; alpha-naphthoflavone inhibits the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of MMP1 mRNA]]

PMID:15075337 PMID:19022365

NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097

G

matrix metallopeptidase 2

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP2 mRNA]
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP2 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP2 protein]

PMID:19022365 PMID:31364906

NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870

G

matrix metallopeptidase 3

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP3 mRNA]

NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961

G

matrix metallopeptidase 9

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of MMP9 mRNA]
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP9 mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MMP9 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of and results in increased activity of MMP9 protein]

PMID:19022365 PMID:23462309 PMID:31364906

NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120

G

metallothionein 1

increases expression

alpha-naphthoflavone results in increased expression of MT1 mRNA

NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049
Ensembl chr17:10,826,032...10,827,049

G

mechanistic target of rapamycin kinase

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of MTOR protein]

NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311

G

MYC proto-oncogene, bHLH transcription factor

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of MYC protein]
alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MYC mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of MYC protein]

PMID:22100782 PMID:31364906

NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630

G

myogenin

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in decreased expression of MYOG protein]

NCBI chr13:45,745,455...45,748,044
Ensembl chr13:45,745,436...45,748,039

G

neutrophil cytosolic factor 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of NCF1 mRNA]

NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646

G

NADH:ubiquinone oxidoreductase core subunit S1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NDUFS1 mRNA]

NCBI chr 9:64,546,430...64,579,751
Ensembl chr 9:64,546,225...64,579,893

G

NADH:ubiquinone oxidoreductase core subunit S3

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of NDUFS3 mRNA]

NCBI chr 3:76,876,646...76,883,824
Ensembl chr 3:76,876,646...76,883,824

G

nuclear factor of activated T-cells 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein]

NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028

G

nitric oxide synthase 2

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein]
alpha-naphthoflavone results in increased expression of NOS2 protein

PMID:26086121 PMID:33722737

NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210

G

notch receptor 2

decreases acetylation
increases methylation
multiple interactions

alpha-naphthoflavone results in decreased acetylation of NOTCH2 promoter
alpha-naphthoflavone results in increased methylation of NOTCH2 promoter
alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased acetylation of NOTCH2 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of NOTCH2 mRNA]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased methylation of NOTCH2 promoter]

NCBI chr 2:185,610,594...185,744,088
Ensembl chr 2:185,610,589...185,744,088

G

NAD(P)H quinone dehydrogenase 1

increases activity
increases expression

alpha-naphthoflavone results in increased activity of NQO1 protein
alpha-naphthoflavone results in increased expression of NQO1 mRNA

PMID:16906435 PMID:17069994

NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557

G

nuclear receptor subfamily 1, group I, member 3

increases activity

alpha-naphthoflavone results in increased activity of NR1I3 protein

NCBI chr13:83,632,940...83,638,193
Ensembl chr13:83,632,899...83,637,906

G

nuclear receptor subfamily 2, group F, member 1

affects binding

[alpha-naphthoflavone binds to AHR protein] which binds to NR2F1 protein

NCBI chr 2:8,040,375...8,050,123
Ensembl chr 2:8,040,377...8,050,123

G

poly (ADP-ribose) polymerase 1

increases cleavage

alpha-naphthoflavone results in increased cleavage of PARP1 protein

NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404

G

phosphofructokinase, muscle

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PFKM mRNA]
alpha-naphthoflavone results in increased expression of PFKM mRNA

NCBI chr 7:129,221,679...129,259,192
Ensembl chr 7:129,221,653...129,259,192

G

phosphoglycerate kinase 1

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PGK1 mRNA]
alpha-naphthoflavone results in increased expression of PGK1 mRNA

NCBI chr X:71,271,454...71,287,429
Ensembl chr X:71,271,440...71,287,418

G

phosphoglucomutase 1

increases expression
multiple interactions

alpha-naphthoflavone results in increased expression of PGM1 mRNA
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PGM1 mRNA]

NCBI chr 5:114,595,298...114,654,728
Ensembl chr 5:114,595,293...114,654,728

G

progesterone receptor

increases expression

alpha-naphthoflavone results in increased expression of PGR protein

NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344

G

pyruvate kinase M1/2

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of PKM mRNA]

NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599

G

peroxisome proliferator activated receptor alpha

multiple interactions

alpha-naphthoflavone inhibits the reaction [beta-Naphthoflavone results in increased expression of PPARA protein]

NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346

G

PR/SET domain 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene metabolite results in decreased expression of PRDM1 mRNA]

NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488

G

protein kinase C, beta

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of PRKCB protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of PRKCB protein]

PMID:16797713 PMID:17222441

NCBI chr 1:176,832,173...177,163,539
Ensembl chr 1:176,832,226...177,163,536

G

prolactin

multiple interactions

alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of PRL mRNA]

NCBI chr17:37,859,999...37,870,062
Ensembl chr17:37,860,007...37,870,062

G

prostaglandin-endoperoxide synthase 2

decreases expression
multiple interactions
increases expression

alpha-naphthoflavone results in decreased expression of PTGS2 mRNA
alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]
alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone inhibits the reaction [Chlorpyrifos results in increased expression of PTGS2 protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of PTGS2 protein]; alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone inhibits the reaction [Vehicle Emissions results in increased expression of PTGS2 mRNA]; alpha-naphthoflavone promotes the reaction [Particulate Matter results in increased expression of PTGS2 mRNA]
alpha-naphthoflavone results in increased expression of PTGS2 mRNA

PMID:21162728 PMID:21652769 PMID:22262711 PMID:26358519 PMID:27393915 More...

NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188

G

protein tyrosine kinase 2

multiple interactions

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in decreased phosphorylation of PTK2 protein]

NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783

G

receptor for activated C kinase 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of RACK1 protein]

PMID:16797713 PMID:17222441

NCBI chr10:33,169,415...33,174,896
Ensembl chr10:33,169,169...33,174,975

G

RB transcriptional corepressor 1

multiple interactions

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased phosphorylation of RB1 protein]

NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302

G

RELA proto-oncogene, NF-kB subunit

multiple interactions
decreases expression

alpha-naphthoflavone inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of RELA protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of RELA protein]
alpha-naphthoflavone results in decreased expression of RELA protein

PMID:24431215 PMID:33722737

NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484

G

serpin family B member 2

multiple interactions
decreases expression
increases expression

alpha-naphthoflavone inhibits the reaction [3,4,5,3',4'-pentachlorobiphenyl results in increased expression of SERPINB2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]; alpha-naphthoflavone inhibits the reaction [Tretinoin promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of SERPINB2 mRNA]]
alpha-naphthoflavone results in decreased expression of SERPINB2 mRNA
alpha-naphthoflavone results in increased expression of SERPINB2 mRNA

PMID:15075337 PMID:22262711

NCBI chr13:23,537,312...23,551,823
Ensembl chr13:23,541,400...23,550,408

G

solute carrier family 2 member 1

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of SLC2A1 mRNA]
alpha-naphthoflavone results in increased expression of SLC2A1 mRNA

NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416

G

solute carrier family 5 member 5

multiple interactions

alpha-naphthoflavone inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of SLC5A5 protein]

NCBI chr16:18,546,709...18,556,698
Ensembl chr16:18,546,709...18,556,697

G

SMAD family member 3

multiple interactions

alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of SMAD3 protein]

NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960

G

Sp1 transcription factor

multiple interactions

alpha-naphthoflavone inhibits the reaction [Methylcholanthrene promotes the reaction [AHR protein binds to SP1 promoter]]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased acetylation of SP1 promoter]; alpha-naphthoflavone inhibits the reaction [Methylcholanthrene results in increased expression of SP1 mRNA]

NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961

G

SRC proto-oncogene, non-receptor tyrosine kinase

multiple interactions
increases phosphorylation

SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of CYP1A1 mRNA]; SRC protein affects the reaction [alpha-naphthoflavone results in increased expression of DDIT3 protein]
alpha-naphthoflavone results in increased phosphorylation of SRC protein

NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476

G

signal transducer and activator of transcription 5B

multiple interactions

[alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Hexachlorobenzene results in increased phosphorylation of and results in increased activity of STAT5B protein]

NCBI chr10:85,704,841...85,775,856
Ensembl chr10:85,705,670...85,775,668

G

transcription factor 7

increases expression

alpha-naphthoflavone results in increased expression of TCF7 mRNA

NCBI chr10:36,423,443...36,454,350
Ensembl chr10:36,423,445...36,453,535

G

transforming growth factor, beta 1

multiple interactions

alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of TGFB1 mRNA]
alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased expression of TGFB1 mRNA]

PMID:22975028 PMID:27519288

NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847

G

TCDD-inducible poly(ADP-ribose) polymerase

decreases expression
multiple interactions

alpha-naphthoflavone results in decreased expression of TIPARP mRNA
alpha-naphthoflavone promotes the reaction [Particulate Matter results in increased expression of TIPARP mRNA]

PMID:18762178 PMID:21652769

NCBI chr 2:149,753,682...149,780,327
Ensembl chr 2:149,753,682...149,780,327

G

tumor necrosis factor

multiple interactions

alpha-naphthoflavone inhibits the reaction [3,4,3',4'-tetrachlorobiphenyl results in increased expression of TNF mRNA]
alpha-naphthoflavone inhibits the reaction [Particulate Matter results in increased expression of TNF mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of TNF mRNA]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of TNF protein]

PMID:17934341 PMID:20801209 PMID:23099484

NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629

G

TNF receptor superfamily member 1A

multiple interactions

alpha-naphthoflavone inhibits the reaction [hydroquinone results in increased expression of TNFRSF1A protein]

NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591

G

TNF receptor superfamily member 1B

multiple interactions

alpha-naphthoflavone inhibits the reaction [hydroquinone results in increased expression of TNFRSF1B protein]

NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206

G

TNF superfamily member 11

multiple interactions

alpha-naphthoflavone inhibits the reaction [norisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]]

NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445

G

tumor protein p53

multiple interactions
increases expression

alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [leptomycin B results in increased expression of TP53 protein]]
alpha-naphthoflavone inhibits the reaction [[CYP1B1 protein results in increased metabolism of 9,10-Dimethyl-1,2-benzanthracene] which results in increased expression of TP53 protein modified form]
alpha-naphthoflavone results in increased expression of TP53 protein
alpha-naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased phosphorylation of TRP53 protein]; alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene affects the localization of TRP53 protein]

PMID:9006915 PMID:15459018 PMID:29274324 PMID:32553695 PMID:35908932

NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524

G

triosephosphate isomerase 1

increases expression
multiple interactions

alpha-naphthoflavone results in increased expression of TPI1 mRNA
alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of TPI1 mRNA]

NCBI chr 4:157,615,283...157,618,813
Ensembl chr 4:157,615,386...157,619,541

G

vitamin D receptor

multiple interactions

alpha-naphthoflavone inhibits the reaction [Benzo(a)pyrene inhibits the reaction [Calcitriol promotes the reaction [VDR protein binds to CYP24A1 promoter]]]

NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677

G

vascular endothelial growth factor A

multiple interactions

alpha-naphthoflavone affects the reaction [Hexachlorobenzene results in increased expression of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Hexachlorobenzene results in increased secretion of VEGFA protein]; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of VEGFA protein]; alpha-naphthoflavone promotes the reaction [Chlorpyrifos results in increased expression of VEGFA protein]
alpha-naphthoflavone inhibits the reaction [norisoboldine results in decreased expression of VEGFA mRNA]
alpha-naphthoflavone inhibits the reaction [norisoboldine inhibits the reaction [TNFSF11 protein results in increased expression of VEGFA mRNA]]

PMID:19182260 PMID:26221077 PMID:26358519 PMID:32526215

NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641

G

vimentin

multiple interactions

alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of VIM mRNA]; alpha-naphthoflavone inhibits the reaction [4-hydroxyestradiol results in increased expression of VIM protein]

NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187

G

WAPL cohesin release factor

multiple interactions

alpha-naphthoflavone promotes the reaction [3-methylcholanthrylene results in increased expression of WAPL mRNA]

NCBI chr16:10,005,520...10,075,270
Ensembl chr16:10,004,941...10,073,510

beta-naphthoflavone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

alpha-1-B glycoprotein

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of A1BG mRNA

NCBI chr 7:92,493,934...92,498,460
Ensembl chr 7:92,494,372...92,498,097

G

alpha-2-macroglobulin

decreases expression

beta-Naphthoflavone results in decreased expression of A2M mRNA

NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786

G

alpha 1,3-galactosyltransferase 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of A3GALT2 mRNA

NCBI chr 5:141,101,329...141,113,760
Ensembl chr 5:141,107,983...141,115,641

G

arylacetamide deacetylase

decreases expression

beta-Naphthoflavone results in decreased expression of AADAC mRNA

NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734

G

ATP binding cassette subfamily B member 6

increases expression

beta-Naphthoflavone results in increased expression of ABCB6 mRNA

NCBI chr 9:76,668,554...76,677,263
Ensembl chr 9:76,668,554...76,676,924

G

ATP binding cassette subfamily C member 1

increases expression

beta-Naphthoflavone results in increased expression of ABCC1 mRNA

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

ATP binding cassette subfamily C member 2

increases expression
decreases expression
multiple interactions

beta-Naphthoflavone results in increased expression of ABCC2 mRNA
beta-Naphthoflavone results in decreased expression of ABCC2 mRNA
[beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC2 mRNA

PMID:11752103 PMID:15833929 PMID:16426233 PMID:19737606 PMID:20607812 More...

NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238

G

ATP binding cassette subfamily C member 3

multiple interactions
increases expression

[beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC3 mRNA
beta-Naphthoflavone results in increased expression of ABCC3 mRNA

PMID:15833929 PMID:19118567 PMID:23994337

NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595

G

ATP binding cassette subfamily C member 4

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ABCC4 mRNA

NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283

G

ATP binding cassette subfamily C member 5

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of ABCC5 mRNA
[beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC5 mRNA

NCBI chr11:80,473,809...80,567,257
Ensembl chr11:80,473,872...80,567,253

G

ATP binding cassette subfamily C member 6

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of ABCC6 mRNA
[beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC6 mRNA

NCBI chr 1:96,447,224...96,501,464
Ensembl chr 1:96,447,251...96,501,464

G

ATP binding cassette subfamily C member 9

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ABCC9 mRNA

NCBI chr 4:175,531,854...175,655,849
Ensembl chr 4:175,532,547...175,655,356

G

ATP binding cassette subfamily E member 1

increases expression

beta-Naphthoflavone results in increased expression of ABCE1 mRNA

NCBI chr19:28,205,566...28,230,489
Ensembl chr19:28,205,555...28,230,489

G

ATP binding cassette subfamily G member 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ABCG1 mRNA

NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948

G

ATP binding cassette subfamily G member 2

increases expression

beta-Naphthoflavone results in increased expression of ABCG2 mRNA

NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409

G

acetyl-CoA carboxylase beta

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ACACB mRNA

NCBI chr12:42,365,800...42,477,651
Ensembl chr12:42,366,548...42,457,655

G

ArfGAP with coiled-coil, ankyrin repeat and PH domains 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACAP2 mRNA

NCBI chr11:69,538,487...69,654,156
Ensembl chr11:69,538,546...69,654,151

G

acetyl-CoA acetyltransferase 2

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ACAT2 mRNA
beta-Naphthoflavone results in decreased expression of ACAT2 mRNA
AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of ACAT2 mRNA]

PMID:18164116 PMID:22234961 PMID:31225620

NCBI chr 1:47,695,833...47,713,879
Ensembl chr 1:47,695,788...47,752,821

G

acyl-CoA binding domain containing 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACBD3 mRNA

NCBI chr13:92,455,813...92,484,556
Ensembl chr13:92,455,655...92,483,380

G

angiotensin I converting enzyme

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACE mRNA

NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131

G

acyl-CoA thioesterase 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ACOT1 mRNA

NCBI chr 6:103,636,173...103,644,167
Ensembl chr 6:103,636,041...103,644,163

G

acyl-CoA thioesterase 7

increases expression

beta-Naphthoflavone results in increased expression of ACOT7 mRNA

NCBI chr 5:162,686,562...162,779,309
Ensembl chr 5:162,684,645...162,779,309

G

acyl-CoA synthetase long-chain family member 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ACSL3 mRNA

NCBI chr 9:80,115,164...80,164,636
Ensembl chr 9:80,115,112...80,164,627

G

activin A receptor like type 1

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ACVRL1 mRNA
beta-Naphthoflavone results in decreased expression of ACVRL1 mRNA

PMID:18164116 PMID:32858204

NCBI chr 7:132,239,200...132,256,592
Ensembl chr 7:132,239,729...132,256,591

G

aminoacylase 1

increases expression

beta-Naphthoflavone results in increased expression of ACY1 mRNA

NCBI chr 8:107,072,354...107,077,756
Ensembl chr 8:107,072,358...107,077,682

G

ADAM metallopeptidase domain 12

decreases expression

beta-Naphthoflavone results in decreased expression of ADAM12 mRNA

NCBI chr 1:188,686,984...189,014,206
Ensembl chr 1:188,686,989...189,020,667

G

ADAM metallopeptidase domain 19

decreases expression

beta-Naphthoflavone results in decreased expression of ADAM19 mRNA

NCBI chr10:30,491,362...30,583,115
Ensembl chr10:30,491,405...30,583,105

G

ADAM metallopeptidase domain 2

increases expression

beta-Naphthoflavone results in increased expression of ADAM2 mRNA

NCBI chr15:40,242,651...40,284,025
Ensembl chr15:40,242,783...40,283,952

G

ADAM-like, decysin 1

increases expression

beta-Naphthoflavone results in increased expression of ADAMDEC1 mRNA

NCBI chr15:42,900,629...42,921,684
Ensembl chr15:42,900,636...42,921,712

G

adenylate cyclase 3

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ADCY3 mRNA
beta-Naphthoflavone results in decreased expression of ADCY3 mRNA

PMID:18164116 PMID:32858204

NCBI chr 6:27,100,089...27,203,686
Ensembl chr 6:27,124,828...27,203,686

G

adenylate cyclase 8

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ADCY8 mRNA

NCBI chr 7:96,417,310...96,665,911
Ensembl chr 7:96,417,324...96,665,911

G

adhesion G protein-coupled receptor E5

decreases expression

beta-Naphthoflavone results in decreased expression of ADGRE5 mRNA

NCBI chr19:24,397,972...24,418,648
Ensembl chr19:24,398,689...24,418,638

G

adhesion G protein-coupled receptor G1

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ADGRG1 mRNA
beta-Naphthoflavone results in decreased expression of ADGRG1 mRNA

PMID:18164116 PMID:32858204

NCBI chr19:10,003,963...10,041,122
Ensembl chr19:10,003,975...10,041,108

G

adhesion G protein-coupled receptor G2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ADGRG2 mRNA

NCBI chr X:34,297,402...34,422,590
Ensembl chr X:34,297,402...34,422,609

G

adhesion G protein-coupled receptor G6

decreases expression

beta-Naphthoflavone results in decreased expression of ADGRG6 mRNA

NCBI chr 1:8,812,889...8,954,239
Ensembl chr 1:8,812,904...8,954,123

G

adhesion G protein-coupled receptor L2

multiple interactions
decreases expression

AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of ADGRL2 mRNA]

NCBI chr 2:237,696,055...238,327,141
Ensembl chr 2:237,696,056...238,327,141

G

alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of ADH7 mRNA

NCBI chr 2:226,748,724...226,763,183
Ensembl chr 2:226,741,788...226,763,182

G

alcohol dehydrogenase, iron containing, 1

decreases expression

beta-Naphthoflavone results in decreased expression of ADHFE1 mRNA

NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517

G

adrenomedullin

increases expression

beta-Naphthoflavone results in increased expression of ADM mRNA

NCBI chr 1:164,745,484...164,747,655
Ensembl chr 1:164,745,466...164,747,654

G

adrenoceptor beta 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ADRB3 mRNA

NCBI chr16:64,839,820...64,844,552
Ensembl chr16:64,841,788...64,844,552

G

ADRM1 26S proteasome ubiquitin receptor

increases expression

beta-Naphthoflavone results in increased expression of ADRM1 mRNA

NCBI chr 3:167,265,435...167,270,197
Ensembl chr 3:167,265,296...167,270,195

G

alanine--glyoxylate aminotransferase

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of AGXT mRNA

NCBI chr 9:93,675,384...93,685,337
Ensembl chr 9:93,675,384...93,685,336

G

aryl hydrocarbon receptor

affects binding
affects localization
decreases expression
increases expression
affects folding
multiple interactions
increases activity
affects response to substance

[beta-Naphthoflavone binds to AHR protein] which binds to ESR1 protein; [beta-Naphthoflavone binds to AHR protein] which binds to ESRRA protein; [beta-Naphthoflavone binds to AHR protein] which binds to NR2F1 protein; beta-Naphthoflavone binds to AHR protein
beta-Naphthoflavone affects the localization of AHR protein
beta-Naphthoflavone results in decreased expression of AHR mRNA; beta-Naphthoflavone results in decreased expression of AHR protein
beta-Naphthoflavone results in increased expression of AHR mRNA
beta-Naphthoflavone affects the folding of AHR protein
AHR protein promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in decreased expression of AHR mRNA]; beta-Naphthoflavone binds to and results in increased activity of AHR protein; beta-Naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]
beta-Naphthoflavone results in increased activity of AHR protein
AHR protein affects the susceptibility to beta-Naphthoflavone
[beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC2 mRNA; [beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC3 mRNA; [beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC5 mRNA; [beta-Naphthoflavone binds to AHR protein] which results in increased expression of ABCC6 mRNA; [beta-Naphthoflavone binds to and affects the localization of AHR protein] promotes the reaction [[AHR protein binds to CYP1A1 enhancer] which results in increased expression of CYP1A1 mRNA]; [beta-Naphthoflavone binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [furafylline results in decreased activity of CYP1A2 protein] promotes the reaction [beta-Naphthoflavone results in increased activity of AHR protein]; AHR affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; AHR affects the reaction [beta-Naphthoflavone results in increased expression of PPARA mRNA]; AHR affects the reaction [beta-Naphthoflavone results in increased expression of PPARA protein]; AHR gene alternative form affects the reaction [beta-Naphthoflavone results in decreased expression of CSN2 mRNA]; AHR gene alternative form affects the reaction [beta-Naphthoflavone results in decreased expression of LALBA mRNA]; AHR gene alternative form affects the reaction [beta-Naphthoflavone results in decreased expression of WAP mRNA]; AHR gene alternative form affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; AHR promotes the reaction [beta-Naphthoflavone results in decreased abundance of Lactic Acid]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of ACAT2 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of ADGRL2 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CES2E mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CES3 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of COQ10B mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CYB5B mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CYP51 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of DHCR7 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of DMGDH mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of FDFT1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of FOS protein]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of GBP6 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HAGH mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCR mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCS1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HSD17B7 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of IDI1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of IRGM mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of LSS mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of MSMO1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of MVD mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of NAT8F2 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of NSDHL mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of PCSK9 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of PMVK mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of RCAN2 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of RDH11 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of SERPINA7 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of SQLE mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of UGCG mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in increased expression of UBE2L3 mRNA]; AHR protein promotes the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]; beta-Naphthoflavone binds to and affects the localization of AHR protein; beta-Naphthoflavone binds to and results in increased activity of AHR protein; beta-Naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin binds to AHR protein]; beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]; beta-Naphthoflavone promotes the reaction [AHR protein binds to BMAL1 protein]; beta-Naphthoflavone promotes the reaction [AHR protein binds to PER1 promoter]; beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]; kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]
AHR gene alternative form affects the susceptibility to beta-Naphthoflavone; AHR protein affects the susceptibility to beta-Naphthoflavone
[beta-Naphthoflavone binds to and results in increased activity of AHR protein] results in decreased susceptibility to [1-nitropyrene results in increased expression of TP53 protein]; [beta-Naphthoflavone results in increased activity of AHR protein] which results in decreased chemical synthesis of and results in decreased secretion of Cholesterol; AHR gene mutant form inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; AHR mutant form inhibits the reaction [beta-Naphthoflavone results in increased activity of [FASLG protein binds to FASLG protein]]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CYP1A1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of FDFT1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of HMGCR mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of LSS mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of SQLE mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone binds to and results in increased activity of AHR protein; beta-Naphthoflavone binds to and results in increased activity of AHR protein polymorphism; beta-Naphthoflavone binds to and results in increased activity of and results in increased localization of AHR protein; beta-Naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; beta-Naphthoflavone promotes the reaction [[AHR protein binds to UGT1A1 enhancer] which results in increased expression of UGT1A1 mRNA]; beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]; beta-Naphthoflavone promotes the reaction [AHR protein binds to GSTA1 promoter]; beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]; Carbaryl inhibits the reaction [beta-Naphthoflavone binds to and results in increased activity of AHR protein]; cryptotanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]; dihydrotanshinone I promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]; NR1I2 protein inhibits the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]; Pregnenolone Carbonitrile promotes the reaction [NR1I2 protein inhibits the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]]; tanshinone promotes the reaction [beta-Naphthoflavone results in increased expression of AHR mRNA]

PMID:3005314 PMID:9407059 PMID:10620335 PMID:11752103 PMID:11752201 More...

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

aryl-hydrocarbon receptor repressor

multiple interactions
increases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of AHRR mRNA
beta-Naphthoflavone results in increased expression of AHRR mRNA

PMID:12520768 PMID:18164116 PMID:25218365

NCBI chr 1:28,993,634...29,088,673
Ensembl chr 1:28,993,634...29,088,673

G

adenylate kinase 4

decreases expression

beta-Naphthoflavone results in decreased expression of AK4 mRNA

NCBI chr 5:116,039,222...116,099,064
Ensembl chr 5:116,039,616...116,098,618

G

aldo-keto reductase family 1 member A1

increases expression

beta-Naphthoflavone results in increased expression of AKR1A1 mRNA

NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674

G

aldo-keto reductase family 1, member C1

increases expression

beta-Naphthoflavone results in increased expression of AKR1C1 mRNA

PMID:17253728 PMID:32151702

NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326

G

aldo-keto reductase family 1, member C15

increases expression

beta-Naphthoflavone results in increased expression of AKR1C8 mRNA

NCBI chr17:66,181,493...66,208,090
Ensembl chr17:66,181,493...66,208,061

G

aldo-keto reductase family 1, member C3

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of AKR1C3 mRNA
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of AKR1C18 mRNA

PMID:18164116 PMID:19737606 PMID:32151702

NCBI chr17:66,110,970...66,127,867
Ensembl chr17:66,110,963...66,127,873

G

aldo-keto reductase family 1, member D1

decreases expression

beta-Naphthoflavone results in decreased expression of AKR1D1 mRNA

NCBI chr 4:66,154,246...66,187,505
Ensembl chr 4:66,154,248...66,186,372

G

aldo-keto reductase family 1, member E2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of AKR1E1 mRNA

NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441

G

aldo-keto reductase family 7, member A2

increases expression

beta-Naphthoflavone results in increased expression of AKR7A2 mRNA; beta-Naphthoflavone results in increased expression of AKR7A2 protein

NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909

G

aldo-keto reductase family 7 member A3

multiple interactions
increases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of AKR7A3 mRNA
beta-Naphthoflavone results in increased expression of AKR7A3 mRNA

PMID:18164116 PMID:22687991

NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394

G

5'-aminolevulinate synthase 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALAS2 mRNA

NCBI chr X:19,463,146...19,486,526
Ensembl chr X:19,463,171...19,486,519

G

albumin

decreases expression

beta-Naphthoflavone results in decreased expression of ALB mRNA

NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836

G

aldehyde dehydrogenase 1 family, member A1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALDH1A1 mRNA

NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961

G

aldehyde dehydrogenase 1 family, member B1

increases expression

beta-Naphthoflavone results in increased expression of ALDH1B1 mRNA

NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378

G

aldehyde dehydrogenase 3 family, member A1

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of ALDH3A1 mRNA
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALDH3A1 mRNA

PMID:1416978 PMID:17998271 PMID:18164116 PMID:23994337 PMID:25218365 More...

NCBI chr10:45,892,993...45,902,680
Ensembl chr10:45,892,924...45,902,681

G

aldehyde dehydrogenase 3 family, member B1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALDH3B1 mRNA

NCBI chr 1:201,145,309...201,162,675
Ensembl chr 1:201,145,309...201,163,921

G

aldehyde dehydrogenase 3 family, member B2

decreases expression

beta-Naphthoflavone results in decreased expression of ALDH3B2 mRNA

NCBI chr 1:201,250,260...201,264,699
Ensembl chr 1:201,253,157...201,264,705

G

aldehyde dehydrogenase 3 family, member B3

decreases expression

beta-Naphthoflavone results in decreased expression of ALDH3B2 mRNA

NCBI chr 1:201,193,832...201,201,666
Ensembl chr 1:201,187,962...201,250,204

G

aldehyde dehydrogenase 8 family, member A1

decreases expression

beta-Naphthoflavone results in decreased expression of ALDH8A1 mRNA

NCBI chr 1:16,183,940...16,203,385
Ensembl chr 1:16,183,940...16,203,385

G

arachidonate 5-lipoxygenase

increases expression

beta-Naphthoflavone results in increased expression of ALOX5 mRNA

NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743

G

alkaline phosphatase, biomineralization associated

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ALPL mRNA

NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446

G

adenosine monophosphate deaminase 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of AMPD3 mRNA

NCBI chr 1:164,884,823...164,929,899
Ensembl chr 1:164,885,320...164,929,887

G

ankyrin repeat domain 1

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of ANKRD1 mRNA

NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919

G

acidic nuclear phosphoprotein 32 family member A

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ANP32A mRNA

NCBI chr 8:62,829,099...62,865,443
Ensembl chr 8:62,827,456...62,865,443

G

annexin A1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ANXA1 mRNA

NCBI chr 1:217,861,175...217,877,205
Ensembl chr 1:217,861,175...217,877,343

G

annexin A4

decreases expression

beta-Naphthoflavone results in decreased expression of ANXA4 mRNA

NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161

G

annexin A5

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ANXA5 mRNA

NCBI chr 2:119,314,007...119,344,703
Ensembl chr 2:119,314,007...119,353,369

G

annexin A8

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ANXA8 mRNA

NCBI chr16:9,397,144...9,412,072
Ensembl chr16:9,397,113...9,412,043

G

amine oxidase, copper containing 1

decreases expression

beta-Naphthoflavone results in decreased expression of AOC1 mRNA

NCBI chr 4:77,812,260...77,831,846
Ensembl chr 4:77,812,260...77,831,840

G

adaptor related protein complex 1 subunit sigma 1

increases expression

beta-Naphthoflavone results in increased expression of AP1S1 mRNA

NCBI chr12:19,625,267...19,635,792
Ensembl chr12:19,625,332...19,756,713

G

amyloid P component, serum

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APCS mRNA

NCBI chr13:85,373,219...85,374,195
Ensembl chr13:85,373,220...85,374,298

G

apelin

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of APLN mRNA

NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391

G

apolipoprotein A4

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APOA4 mRNA

NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469

G

apolipoprotein A5

decreases expression

beta-Naphthoflavone results in decreased expression of APOA5 mRNA

NCBI chr 8:46,561,180...46,563,818
Ensembl chr 8:46,561,229...46,563,816

G

apolipoprotein B mRNA editing enzyme catalytic subunit 2

decreases expression

beta-Naphthoflavone results in decreased expression of APOBEC2 mRNA

NCBI chr 9:12,564,955...12,578,461
Ensembl chr 9:12,564,920...12,578,458

G

apolipoprotein M

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of APOM mRNA

NCBI chr20:3,690,950...3,693,550
Ensembl chr20:3,688,413...3,693,550

G

adenine phosphoribosyl transferase

increases expression

beta-Naphthoflavone results in increased expression of APRT mRNA

NCBI chr19:50,626,201...50,628,491
Ensembl chr19:50,626,202...50,628,431

G

aprataxin

increases expression

beta-Naphthoflavone results in increased expression of APTX mRNA

NCBI chr 5:55,798,896...55,822,963
Ensembl chr 5:55,800,248...55,822,855

G

Rho/Rac guanine nucleotide exchange factor 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ARHGEF2 mRNA

NCBI chr 2:174,061,126...174,118,355
Ensembl chr 2:174,062,976...174,118,355

G

AT-rich interaction domain 5B

decreases expression

beta-Naphthoflavone results in decreased expression of ARID5B mRNA

NCBI chr20:20,307,731...20,490,746
Ensembl chr20:20,307,731...20,487,433

G

ADP ribosylation factor like GTPase 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ARL3 mRNA

NCBI chr 1:245,400,659...245,446,673
Ensembl chr 1:245,400,550...245,446,820

G

aryl hydrocarbon receptor nuclear translocator

multiple interactions

ARNT affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; ARNT promotes the reaction [beta-Naphthoflavone results in decreased abundance of Lactic Acid]; beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]; beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]; kaempferol inhibits the reaction [beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]
AHR gene mutant form inhibits the reaction [beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]]; beta-Naphthoflavone promotes the reaction [AHR protein binds to ARNT protein]; beta-Naphthoflavone results in increased activity of [AHR protein binds to ARNT protein]

PMID:17012224 PMID:19901195 PMID:21127131 PMID:21849270 PMID:24486526

NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580

G

aryl hydrocarbon receptor nuclear translocator 2

increases expression

beta-Naphthoflavone results in increased expression of ARNT2 mRNA

NCBI chr 1:138,236,235...138,392,868
Ensembl chr 1:138,189,940...138,393,153

G

arrestin domain containing 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ARRDC2 mRNA

NCBI chr16:18,601,897...18,606,029
Ensembl chr16:18,601,897...18,606,029

G

ArfGAP with SH3 domain, ankyrin repeat and PH domain 1

increases expression

beta-Naphthoflavone results in increased expression of ASAP1 mRNA

NCBI chr 7:95,786,130...96,093,111
Ensembl chr 7:95,787,818...96,092,754

G

asparagine synthetase (glutamine-hydrolyzing)

increases expression

beta-Naphthoflavone results in increased expression of ASNS mRNA

PMID:17175557 PMID:32858204

NCBI chr 4:35,784,995...35,803,474
Ensembl chr 4:35,785,237...35,803,423

G

atos homolog B

increases expression

beta-Naphthoflavone results in increased expression of ATOSB mRNA

NCBI chr 5:57,260,839...57,274,524
Ensembl chr 5:57,260,841...57,268,892

G

ATPase Na+/K+ transporting subunit beta 3

increases expression

beta-Naphthoflavone results in increased expression of ATP1B3 mRNA

NCBI chr 8:96,910,265...96,941,592
Ensembl chr 8:96,910,309...96,941,598

G

ATPase plasma membrane Ca2+ transporting 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ATP2B2 mRNA

NCBI chr 4:146,894,602...147,208,060
Ensembl chr 4:146,896,332...147,140,665

G

ATP synthase F1 subunit beta

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of ATP5F1B protein; [Piperonyl Butoxide co-treated with beta-Naphthoflavone] results in decreased expression of ATP5F1B protein

NCBI chr 7:515,454...521,858
Ensembl chr 7:515,460...567,273

G

ATPase H+ transporting V1 subunit B1

decreases expression

beta-Naphthoflavone results in decreased expression of ATP6V1B1 mRNA

NCBI chr 4:116,223,799...116,242,475
Ensembl chr 4:116,223,799...116,242,475

G

ATPase H+ transporting V1 subunit C2

decreases expression

beta-Naphthoflavone results in decreased expression of ATP6V1C2 mRNA

NCBI chr 6:40,080,545...40,144,199
Ensembl chr 6:40,080,547...40,120,028

G

ATPase copper transporting beta

decreases expression

beta-Naphthoflavone results in decreased expression of ATP7B mRNA

NCBI chr16:69,952,286...70,024,404
Ensembl chr16:69,951,778...70,023,636

G

ataxin 10

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ATXN10 mRNA

NCBI chr 7:116,441,768...116,565,093
Ensembl chr 7:116,441,613...116,565,087

G

AUP1, lipid droplet regulating VLDL assembly factor

increases expression

beta-Naphthoflavone results in increased expression of AUP1 mRNA

NCBI chr 4:115,560,274...115,563,346
Ensembl chr 4:115,560,261...115,563,346

G

advillin

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of AVIL mRNA

NCBI chr 7:62,825,459...62,844,103
Ensembl chr 7:62,826,025...62,844,071

G

acyl-CoA wax alcohol acyltransferase 1

decreases expression

beta-Naphthoflavone results in decreased expression of AWAT1 mRNA

NCBI chr X:65,668,205...65,674,450
Ensembl chr X:65,668,205...65,674,450

G

beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of B3GALNT1 mRNA

NCBI chr 2:153,847,297...153,877,371
Ensembl chr 2:153,846,474...153,877,332

G

BAF nuclear assembly factor 1

decreases expression

beta-Naphthoflavone results in decreased expression of BANF1 mRNA

NCBI chr 1:202,672,170...202,674,215
Ensembl chr 1:202,671,305...202,674,188

G

brain abundant, membrane attached signal protein 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BASP1 mRNA

NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043

G

branched chain amino acid transaminase 1

decreases expression

beta-Naphthoflavone results in decreased expression of BCAT1 mRNA

NCBI chr 4:177,964,834...178,046,573
Ensembl chr 4:177,964,834...178,046,597

G

BCL2, apoptosis regulator

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of BCL2 mRNA
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BCL2 mRNA

PMID:21295105 PMID:22687991

NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743

G

BCL9 like

increases expression

beta-Naphthoflavone results in increased expression of BCL9L mRNA

NCBI chr 8:44,811,977...44,840,611
Ensembl chr 8:44,811,977...44,840,611

G

brain expressed X-linked 3

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BEX3 mRNA
beta-Naphthoflavone results in decreased expression of BEX3 mRNA

PMID:18164116 PMID:32858204

NCBI chr X:99,273,270...99,274,799
Ensembl chr X:99,273,161...99,274,800

G

brain expressed, X-linked 4

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BEX4 mRNA

NCBI chr X:99,131,985...99,133,417
Ensembl chr X:99,131,942...99,133,531

G

biglycan

decreases expression

beta-Naphthoflavone results in decreased expression of BGN mRNA

NCBI chr X:151,197,296...151,209,458
Ensembl chr X:151,197,273...151,209,461

G

basic helix-loop-helix family, member e41

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BHLHE41 mRNA

NCBI chr 4:178,834,264...178,838,618
Ensembl chr 4:178,834,271...178,838,468

G

betaine-homocysteine S-methyltransferase

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of BHMT mRNA

NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742

G

baculoviral IAP repeat-containing 3

increases expression

beta-Naphthoflavone results in increased expression of BIRC3 mRNA

NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802

G

baculoviral IAP repeat-containing 5

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BIRC5 mRNA

NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380

G

B-cell linker

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BLNK mRNA

NCBI chr 1:239,753,640...239,821,113
Ensembl chr 1:239,753,648...239,821,113

G

biliverdin reductase B

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of BLVRB mRNA

NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375

G

basic helix-loop-helix ARNT like 1

multiple interactions
increases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of BMAL1 mRNA
beta-Naphthoflavone results in increased expression of BMAL1 mRNA
beta-Naphthoflavone inhibits the reaction [CLOCK protein binds to BMAL1 protein]; beta-Naphthoflavone promotes the reaction [AHR protein binds to BMAL1 protein]; BMAL1 affects the reaction [beta-Naphthoflavone results in increased expression of PPARA mRNA]

PMID:18164116 PMID:20106950 PMID:21849270 PMID:32151702

NCBI chr 1:167,331,756...167,430,235
Ensembl chr 1:167,331,633...167,430,231

G

BCL2 family apoptosis regulator BOK

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BOK mRNA

NCBI chr 9:94,223,493...94,234,476
Ensembl chr 9:94,223,389...94,234,476

G

bisphosphoglycerate mutase

decreases expression

beta-Naphthoflavone results in decreased expression of BPGM mRNA

NCBI chr 4:63,139,730...63,168,581
Ensembl chr 4:63,140,018...63,168,581

G

BMP/retinoic acid inducible neural specific 1

increases expression

beta-Naphthoflavone results in increased expression of BRINP1 mRNA

NCBI chr 5:82,348,501...82,550,506
Ensembl chr 5:82,348,930...82,493,150

G

B-box and SPRY domain containing

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BSPRY mRNA

NCBI chr 5:75,927,397...75,949,585
Ensembl chr 5:75,927,405...75,949,583

G

BTG anti-proliferation factor 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of BTG3 mRNA

NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170

G

C1q and TNF related 1

decreases expression

beta-Naphthoflavone results in decreased expression of C1QTNF1 mRNA

NCBI chr10:103,660,319...103,681,662
Ensembl chr10:103,660,327...103,681,660

G

C1q and TNF related 6

decreases expression

beta-Naphthoflavone results in decreased expression of C1QTNF6 mRNA

NCBI chr 7:110,077,867...110,084,584
Ensembl chr 7:110,077,878...110,084,412

G

similar to human chromosome 11 open reading frame 96

decreases expression

beta-Naphthoflavone results in decreased expression of C11ORF96 mRNA

NCBI chr 3:79,920,125...79,921,368
Ensembl chr 3:79,920,129...79,921,523

G

similar to human chromosome 2 open reading frame 88

decreases expression

beta-Naphthoflavone results in decreased expression of C2ORF88 mRNA

NCBI chr 9:48,539,140...48,584,882
Ensembl chr 9:48,568,409...48,584,831

G

calcium binding protein 39-like

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CAB39L mRNA

NCBI chr15:33,606,588...33,710,518
Ensembl chr15:33,606,694...33,743,545

G

calcium voltage-gated channel auxiliary subunit alpha2delta 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CACNA2D1 mRNA

NCBI chr 4:18,950,611...19,374,969
Ensembl chr 4:18,951,002...19,374,969

G

calcium voltage-gated channel auxiliary subunit gamma 5

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CACNG5 mRNA

NCBI chr10:92,827,441...92,869,632
Ensembl chr10:92,829,196...92,869,614

G

calpain 6

decreases expression

beta-Naphthoflavone results in decreased expression of CAPN6 mRNA

NCBI chr X:107,380,774...107,405,489
Ensembl chr X:107,380,774...107,405,489

G

calcyphosine

decreases expression

beta-Naphthoflavone results in decreased expression of CAPS mRNA

NCBI chr 9:1,544,597...1,545,631
Ensembl chr 9:1,544,719...1,545,647

G

carbonic anhydrase 11

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CAR11 mRNA

NCBI chr 1:96,169,900...96,175,191
Ensembl chr 1:96,170,080...96,175,191

G

carbonic anhydrase 2

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CA2 mRNA
beta-Naphthoflavone results in decreased expression of CA2 mRNA

PMID:18164116 PMID:32858204

NCBI chr 2:86,741,625...86,756,766
Ensembl chr 2:86,741,626...86,756,818

G

carbonic anhydrase 3

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CA3 mRNA
beta-Naphthoflavone results in decreased expression of CAR3 mRNA

PMID:18164116 PMID:23994337

NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280

G

caspase 1

decreases expression

beta-Naphthoflavone results in decreased expression of CASP1 mRNA

NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383

G

caspase 3

multiple interactions

beta-Naphthoflavone inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]

NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648

G

caveolin 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CAV mRNA

NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705

G

Cbl proto-oncogene C

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CBLC mRNA

NCBI chr 1:79,439,975...79,456,755
Ensembl chr 1:79,439,977...79,456,755

G

carbonyl reductase 1

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of CBR1 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR1 mRNA

PMID:17569794 PMID:19737545 PMID:19737606

NCBI chr11:32,860,571...32,862,981
Ensembl chr11:32,908,950...32,911,393
Ensembl chr11:32,908,950...32,911,393

G

carbonyl reductase 3

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CBR3 mRNA

NCBI chr11:33,008,615...33,016,877
Ensembl chr11:33,008,615...33,016,875

G

coiled-coil domain containing 80

decreases expression

beta-Naphthoflavone results in decreased expression of CCDC80 mRNA

NCBI chr11:55,685,165...55,718,827
Ensembl chr11:55,685,872...55,719,137

G

coiled-coil domain containing 85B

increases expression

beta-Naphthoflavone results in increased expression of CCDC85B mRNA

NCBI chr 1:202,763,645...202,764,660
Ensembl chr 1:202,763,631...202,764,703

G

cholecystokinin

decreases expression

beta-Naphthoflavone results in decreased expression of CCK mRNA

NCBI chr 8:121,153,499...121,160,194
Ensembl chr 8:121,153,500...121,160,084

G

cholecystokinin B receptor

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCKBR mRNA

NCBI chr 1:159,771,733...159,781,738
Ensembl chr 1:159,771,733...159,814,881

G

C-C motif chemokine ligand 2

multiple interactions
increases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCL2 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCL2 mRNA]
beta-Naphthoflavone results in increased expression of CCL2 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCL2 mRNA

PMID:19737545 PMID:21295105 PMID:22687991

NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226

G

C-C motif chemokine ligand 20

decreases expression

beta-Naphthoflavone results in decreased expression of CCL20 mRNA

NCBI chr 9:84,389,031...84,391,629
Ensembl chr 9:84,388,904...84,391,629

G

C-C motif chemokine ligand 21

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCL21B mRNA

NCBI chr 5:56,980,557...56,981,661
Ensembl chr 5:56,980,558...56,981,686

G

C-C motif chemokine ligand 22

decreases expression

beta-Naphthoflavone results in decreased expression of CCL22 mRNA

NCBI chr19:10,257,602...10,264,373
Ensembl chr19:10,257,601...10,264,400

G

C-C motif chemokine ligand 3

decreases expression

beta-Naphthoflavone results in decreased expression of CCL3 mRNA

NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938

G

C-C motif chemokine ligand 5

decreases expression

beta-Naphthoflavone results in decreased expression of CCL5 mRNA

NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377

G

C-C motif chemokine ligand 9

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CCL6 mRNA

NCBI chr10:68,366,486...68,371,408
Ensembl chr10:68,366,487...68,371,369

G

cellular communication network factor 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCN1 mRNA

NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484

G

cellular communication network factor 2

multiple interactions
decreases expression

[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CCN2 mRNA
beta-Naphthoflavone results in decreased expression of CCN2 mRNA
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCN2 mRNA

PMID:18164116 PMID:19737545 PMID:19737606 PMID:32151702

NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734

G

cellular communication network factor 5

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCN5 mRNA

NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636

G

cyclin A1

decreases expression

beta-Naphthoflavone results in decreased expression of CCNA1 mRNA

NCBI chr 2:139,231,738...139,278,066
Ensembl chr 2:139,201,074...139,243,157

G

cyclin A2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCNA2 mRNA

NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577

G

cyclin B1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCNB1 mRNA

NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172

G

cyclin B2

decreases expression

beta-Naphthoflavone results in decreased expression of CCNB2 mRNA

NCBI chr 8:71,087,594...71,100,794
Ensembl chr 8:71,087,595...71,100,874

G

cyclin D1

decreases expression

beta-Naphthoflavone results in decreased expression of CCND1 mRNA

NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602

G

chaperonin containing TCP1 subunit 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CCT3 mRNA

NCBI chr 2:173,765,701...173,790,353
Ensembl chr 2:173,765,698...173,790,757

G

CD24 molecule

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD24 mRNA

NCBI chr20:47,074,353...47,079,662
Ensembl chr20:47,073,512...47,079,662

G

Cd276 molecule

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD276 mRNA

NCBI chr 8:58,937,751...58,968,082
Ensembl chr 8:58,937,751...58,968,380

G

Cd300 molecule-like family member F

decreases expression

beta-Naphthoflavone results in decreased expression of CD300LF mRNA

NCBI chr10:100,359,942...100,376,130
Ensembl chr10:100,359,943...100,376,041

G

CD36 molecule

increases expression

beta-Naphthoflavone results in increased expression of CD36 mRNA

NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903

G

CD38 molecule

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD38 mRNA

NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986

G

Cd47 molecule

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CD47 mRNA

NCBI chr11:50,906,052...50,970,000
Ensembl chr11:50,906,177...50,969,425

G

Cd48 molecule

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD48 mRNA
beta-Naphthoflavone results in decreased expression of CD48 mRNA

PMID:18164116 PMID:32858204

NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142

G

CD52 molecule

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD52 mRNA
beta-Naphthoflavone results in decreased expression of CD52 mRNA

PMID:18164116 PMID:32858204

NCBI chr 5:146,319,789...146,321,348
Ensembl chr 5:146,319,969...146,321,348

G

Cd63 molecule

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD63 mRNA

NCBI chr 7:1,325,108...1,340,447
Ensembl chr 7:1,325,103...1,399,178

G

CD86 molecule

decreases expression

beta-Naphthoflavone results in decreased expression of CD86 mRNA

NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818

G

CD9 molecule

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CD9 mRNA

NCBI chr 4:158,256,328...158,289,136
Ensembl chr 4:158,256,328...158,289,222

G

cell division cycle 20

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDC20 mRNA
beta-Naphthoflavone results in decreased expression of CDC20 mRNA

PMID:18164116 PMID:21295105 PMID:32858204

NCBI chr 5:131,966,203...131,970,406
Ensembl chr 5:131,966,215...131,970,512

G

CDC42 binding protein kinase alpha

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDC42BPA mRNA

NCBI chr13:91,683,775...91,903,732
Ensembl chr13:91,684,007...91,903,732

G

CDC42 effector protein 2

increases expression

beta-Naphthoflavone results in increased expression of CDC42EP2 mRNA

NCBI chr 1:203,202,000...203,210,891
Ensembl chr 1:203,201,873...203,210,897

G

cell division cycle associated 5

affects expression

beta-Naphthoflavone affects the expression of CDCA5 mRNA

NCBI chr 1:203,378,550...203,392,027
Ensembl chr 1:203,378,577...203,392,023

G

cell division cycle associated 8

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDCA8 mRNA

NCBI chr 5:137,176,414...137,198,686
Ensembl chr 5:137,176,417...137,198,629

G

cadherin 11

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDH11 mRNA

NCBI chr19:2,148,447...2,305,754
Ensembl chr19:2,148,458...2,304,272

G

cadherin 13

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDH13 mRNA

NCBI chr19:46,349,562...47,387,462
Ensembl chr19:46,349,430...47,387,459

G

cadherin 17

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDH17 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CDH17 mRNA

PMID:18164116 PMID:19737545

NCBI chr 5:25,262,820...25,314,884
Ensembl chr 5:25,262,758...25,314,884

G

cadherin 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDH3 mRNA

NCBI chr19:34,393,596...34,444,084
Ensembl chr19:34,393,727...34,444,084

G

cadherin-related family member 5

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDHR5 mRNA

NCBI chr 1:196,373,110...196,381,609
Ensembl chr 1:196,373,112...196,381,543

G

cyclin-dependent kinase 1

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDK1 mRNA
beta-Naphthoflavone results in decreased expression of CDK1 mRNA

PMID:18164116 PMID:32858204

NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408

G

cyclin-dependent kinase 13

increases expression

beta-Naphthoflavone results in increased expression of CDK13 mRNA

NCBI chr17:47,251,145...47,344,675
Ensembl chr17:47,251,163...47,341,721

G

CDK5 regulatory subunit associated protein 2

increases expression

beta-Naphthoflavone results in increased expression of CDK5RAP2 mRNA

NCBI chr 5:83,792,282...83,961,129
Ensembl chr 5:83,792,284...83,960,782

G

cyclin-dependent kinase inhibitor 1A

decreases expression
multiple interactions

beta-Naphthoflavone results in decreased expression of CDKN1A mRNA; beta-Naphthoflavone results in decreased expression of CDKN1A protein
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDKN1A mRNA

PMID:18164116 PMID:19389873 PMID:22687991

NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585

G

cyclin-dependent kinase inhibitor 1C

decreases expression

beta-Naphthoflavone results in decreased expression of CDKN1C mRNA

NCBI chr 1:198,655,394...198,658,097
Ensembl chr 1:198,655,407...198,658,048

G

cyclin-dependent kinase inhibitor 2B

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of CDKN2B mRNA
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDKN2B mRNA]

PMID:21295105 PMID:22687991

NCBI chr 5:104,009,839...104,019,082
Ensembl chr 5:104,010,680...104,019,050

G

cysteine dioxygenase type 1

decreases expression

beta-Naphthoflavone results in decreased expression of CDO1 mRNA

NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296

G

cerebellar degeneration-related protein 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CDR2 mRNA

NCBI chr 1:175,502,837...175,527,746
Ensembl chr 1:175,502,838...175,537,472

G

caudal type homeo box 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CDX2 mRNA

NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142

G

CEA cell adhesion molecule 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CEACAM1 mRNA

NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992

G

CCAAT/enhancer binding protein alpha

decreases expression

beta-Naphthoflavone results in decreased expression of CEBPA mRNA; beta-Naphthoflavone results in decreased expression of CEBPA protein

NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412

G

chymotrypsin like elastase 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CELA1 mRNA

NCBI chr 7:131,773,161...131,786,300
Ensembl chr 7:131,742,002...131,786,285

G

cadherin, EGF LAG seven-pass G-type receptor 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CELSR1 mRNA

NCBI chr 7:116,987,616...117,125,035
Ensembl chr 7:116,987,605...117,125,164

G

centromere protein I

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CENPI mRNA

NCBI chr X:97,515,919...97,567,671
Ensembl chr X:97,515,972...97,567,657

G

centromere protein X

increases expression

beta-Naphthoflavone results in increased expression of CENPX mRNA

NCBI chr10:105,991,469...105,994,310

G

carboxylesterase 1D

increases expression

beta-Naphthoflavone results in increased expression of CES1 mRNA

NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035

G

carboxylesterase 2E

decreases expression
multiple interactions

beta-Naphthoflavone results in decreased expression of CES2E mRNA
AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CES2E mRNA]
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CES2E mRNA

PMID:18164116 PMID:22234961

NCBI chr19:157,447...172,822
Ensembl chr19:157,407...172,856

G

carboxylesterase 3a

multiple interactions
decreases expression

[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CES3 mRNA; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CES3 mRNA]

PMID:19737545 PMID:22234961

NCBI chr19:32,992,386...33,000,562

G

cilia and flagella associated protein 45

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CFAP45 mRNA

NCBI chr13:84,989,474...85,012,880
Ensembl chr13:84,981,728...85,012,878

G

craniofacial development protein 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CFDP1 mRNA

NCBI chr19:39,718,313...39,823,824
Ensembl chr19:39,718,347...39,823,824

G

cholesterol 25-hydroxylase

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CH25H mRNA

NCBI chr 1:232,014,877...232,016,195
Ensembl chr 1:232,014,880...232,016,195

G

coiled-coil-helix-coiled-coil-helix domain containing 6

decreases expression

beta-Naphthoflavone results in decreased expression of CHCHD6 mRNA

NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216

G

choline dehydrogenase

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CHDH mRNA

NCBI chr16:5,194,269...5,225,541
Ensembl chr16:5,194,269...5,225,537

G

chondroitin polymerizing factor

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CHPF mRNA

NCBI chr 9:76,963,178...76,967,878
Ensembl chr 9:76,963,184...76,967,878

G

cholinergic receptor nicotinic beta 1 subunit

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CHRNB1 mRNA

NCBI chr10:54,501,096...54,516,418
Ensembl chr10:54,501,093...54,516,345

G

chondroitin sulfate synthase 1

decreases expression

beta-Naphthoflavone results in decreased expression of CHSY1 mRNA

NCBI chr 1:119,689,626...119,750,711
Ensembl chr 1:119,686,350...119,750,601

G

cytokine inducible SH2-containing protein

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CISH mRNA

NCBI chr 8:107,972,306...107,977,254
Ensembl chr 8:107,972,306...107,977,250

G

Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CITED2 mRNA

NCBI chr 1:12,312,426...12,314,869
Ensembl chr 1:12,312,160...12,314,897

G

CDC28 protein kinase regulatory subunit 1B

decreases expression

beta-Naphthoflavone results in decreased expression of CKS1B mRNA

NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636

G

chloride voltage-gated channel 5

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CLCN5 mRNA

NCBI chr X:15,185,380...15,339,977
Ensembl chr X:15,185,451...15,334,264

G

claudin 1

multiple interactions
increases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CLDN1 mRNA
beta-Naphthoflavone results in increased expression of CLDN1 mRNA

PMID:18164116 PMID:32151702

NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724

G

claudin 4

increases expression

beta-Naphthoflavone results in increased expression of CLDN4 mRNA

NCBI chr12:21,751,638...21,753,436
Ensembl chr12:21,751,331...21,753,436

G

claudin 7

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CLDN7 mRNA

NCBI chr10:54,689,684...54,692,177
Ensembl chr10:54,689,987...54,692,171

G

C-type lectin domain family 12, member A

decreases expression

beta-Naphthoflavone results in decreased expression of CLEC12A mRNA

NCBI chr 4:162,798,125...162,816,757
Ensembl chr 4:162,798,125...162,816,753

G

C-type lectin domain family 1, member A

decreases expression

beta-Naphthoflavone results in decreased expression of CLEC1A mRNA

NCBI chr 4:162,875,360...162,902,571
Ensembl chr 4:162,877,346...162,901,247

G

chloride intracellular channel 1

increases expression

beta-Naphthoflavone results in increased expression of CLIC1 mRNA

NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712

G

clock circadian regulator

multiple interactions

beta-Naphthoflavone inhibits the reaction [CLOCK protein binds to BMAL1 protein]; beta-Naphthoflavone inhibits the reaction [CLOCK protein binds to PER1 promoter]

NCBI chr14:31,908,542...31,992,673
Ensembl chr14:31,908,566...31,990,400

G

caseinolytic mitochondrial matrix peptidase chaperone subunit X

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CLPX mRNA

NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082

G

citramalyl-CoA lyase

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CLYBL mRNA

NCBI chr15:99,283,644...99,505,697
Ensembl chr15:99,283,650...99,505,695

G

cornifelin

increases expression

beta-Naphthoflavone results in increased expression of CNFN mRNA

NCBI chr 1:80,949,699...80,953,747
Ensembl chr 1:80,951,600...80,953,747

G

calponin 2

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CNN2 mRNA

NCBI chr 7:9,712,505...9,719,678
Ensembl chr 7:9,712,516...9,719,656

G

calponin 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CNN3 mRNA

NCBI chr 2:209,518,948...209,550,107
Ensembl chr 2:209,518,948...209,550,104

G

2',3'-cyclic nucleotide 3' phosphodiesterase

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CNP1 mRNA

NCBI chr10:85,511,164...85,517,723
Ensembl chr10:85,511,160...85,517,720

G

collagen type XVI alpha 1 chain

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL16A1 mRNA

NCBI chr 5:142,388,376...142,442,825
Ensembl chr 5:142,388,426...142,442,825

G

collagen type XVII alpha 1 chain

decreases expression

beta-Naphthoflavone results in decreased expression of COL17A1 mRNA

NCBI chr 1:246,530,589...246,577,559
Ensembl chr 1:246,531,367...246,577,632

G

collagen type XVIII alpha 1 chain

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL18A1 mRNA

NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593

G

collagen type I alpha 1 chain

multiple interactions
affects expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL1A1 mRNA
beta-Naphthoflavone affects the expression of COL1A1 mRNA

PMID:18164116 PMID:20045035 PMID:21295105 PMID:23994337

NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624

G

collagen type XXII alpha 1 chain

decreases expression

beta-Naphthoflavone results in decreased expression of COL22A1 mRNA

NCBI chr 7:103,730,939...103,968,452
Ensembl chr 7:103,731,037...103,968,462

G

collagen type XXVII alpha 1 chain

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL27A1 mRNA

NCBI chr 5:76,647,302...76,765,989
Ensembl chr 5:76,647,429...76,765,174

G

collagen type IV alpha 1 chain

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL4A1 mRNA

NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412

G

collagen type V alpha 1 chain

decreases expression

beta-Naphthoflavone results in decreased expression of COL5A1 mRNA

NCBI chr 3:11,208,429...11,356,715
Ensembl chr 3:11,208,512...11,354,588

G

collagen type VI alpha 2 chain

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COL6A2 mRNA

NCBI chr20:12,021,676...12,049,425
Ensembl chr20:12,021,767...12,057,564

G

collectin sub-family member 12

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of COLEC12 mRNA
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COLEC12 mRNA

PMID:18164116 PMID:19737606

NCBI chr18:732,950...920,620
Ensembl chr18:732,950...920,618

G

coenzyme Q10B

decreases expression
multiple interactions

beta-Naphthoflavone results in decreased expression of COQ10B mRNA
AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of COQ10B mRNA]

NCBI chr 9:56,553,751...56,573,671
Ensembl chr 9:56,553,758...56,573,663

G

coenzyme Q8A

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of COQ8A mRNA

NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431

G

cytochrome c oxidase subunit 6B2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of COX6B2 mRNA

NCBI chr 1:69,094,009...69,095,312

G

carboxypeptidase E

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CPE mRNA

NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233

G

coproporphyrinogen oxidase

increases expression

beta-Naphthoflavone results in increased expression of CPOX mRNA

NCBI chr11:41,936,585...41,946,568
Ensembl chr11:41,936,591...41,946,746

G

carboxypeptidase Z

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CPZ mRNA

NCBI chr14:75,223,692...75,246,946
Ensembl chr14:75,223,605...75,246,945

G

CRACD like

decreases expression

beta-Naphthoflavone results in decreased expression of CRACDL mRNA

NCBI chr 9:39,834,321...39,950,763
Ensembl chr 9:39,834,833...39,951,086

G

carnitine O-acetyltransferase

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CRAT mRNA

NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255

G

cysteine-rich C-terminal 1

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CRCT1 mRNA

NCBI chr 2:178,633,789...178,635,274
Ensembl chr 2:178,634,092...178,634,394

G

cAMP responsive element binding protein 1

increases expression

beta-Naphthoflavone results in increased expression of CREB1 mRNA

NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816

G

cAMP responsive element binding protein 5

decreases expression

beta-Naphthoflavone results in decreased expression of CREB5 mRNA

NCBI chr 4:82,393,091...82,794,320
Ensembl chr 4:82,393,730...82,790,325

G

cAMP responsive element modulator

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of CREM mRNA
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CREM mRNA

PMID:18164116 PMID:19737606

NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989

G

corticotropin releasing hormone

decreases expression

beta-Naphthoflavone results in decreased expression of CRH mRNA

NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919

G

cysteine-rich protein 2

decreases expression

beta-Naphthoflavone results in decreased expression of CRIP2 mRNA

NCBI chr 6:132,221,120...132,226,066
Ensembl chr 6:132,221,082...132,226,065

G

cysteine-rich secretory protein 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CRISP2 mRNA

NCBI chr 9:20,107,649...20,131,967
Ensembl chr 9:20,107,701...20,131,959

G

carnitine O-octanoyltransferase

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CROT mRNA

NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109

G

crystallin, alpha B

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CRYAB mRNA
beta-Naphthoflavone results in decreased expression of CRYAB mRNA

PMID:18164116 PMID:32858204

NCBI chr 8:51,093,441...51,099,161
Ensembl chr 8:51,093,441...51,099,157

G

crystallin zeta

multiple interactions
increases activity
increases expression

AHR protein promotes the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]; Copper inhibits the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]; Copper inhibits the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]; Lead inhibits the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]; Mercury promotes the reaction [beta-Naphthoflavone results in increased activity of CRYZ protein]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CRYZ mRNA]

NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758

G

colony stimulating factor 1 receptor

decreases expression

beta-Naphthoflavone results in decreased expression of CSF1R mRNA

NCBI chr18:54,546,673...54,590,418
Ensembl chr18:54,546,659...54,590,415

G

colony stimulating factor 3 receptor

decreases expression

beta-Naphthoflavone results in decreased expression of CSF3R mRNA

NCBI chr 5:138,298,605...138,318,224
Ensembl chr 5:138,301,506...138,317,881

G

CUB and Sushi multiple domains 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CSMD1 mRNA

NCBI chr16:72,218,189...73,818,380
Ensembl chr16:72,218,503...73,817,614

G

casein beta

multiple interactions
decreases expression

AHR gene alternative form affects the reaction [beta-Naphthoflavone results in decreased expression of CSN2 mRNA]; beta-Naphthoflavone inhibits the reaction [[PRL protein co-treated with Dexamethasone] results in increased expression of CSN2 mRNA]
beta-Naphthoflavone results in decreased expression of CSN2 mRNA; beta-Naphthoflavone results in decreased expression of CSN2 protein

NCBI chr14:20,322,581...20,329,818
Ensembl chr14:20,322,581...20,329,817

G

cysteine and glycine-rich protein 2

decreases expression

beta-Naphthoflavone results in decreased expression of CSRP2 mRNA

NCBI chr 7:46,349,109...46,367,743
Ensembl chr 7:46,348,686...46,367,745

G

catenin beta 1

multiple interactions

CTNNB1 gene mutant form affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; CTNNB1 gene mutant form inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA]

NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111

G

cathepsin C

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CTSC mRNA

NCBI chr 1:142,028,386...142,059,841
Ensembl chr 1:142,028,392...142,060,387

G

cullin 5

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CUL5 mRNA

NCBI chr 8:54,012,963...54,066,751
Ensembl chr 8:54,016,006...54,066,666

G

C-X3-C motif chemokine ligand 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CX3CL1 mRNA

NCBI chr19:10,227,337...10,237,826
Ensembl chr19:10,227,340...10,236,833

G

C-X-C motif chemokine ligand 1

increases expression

beta-Naphthoflavone results in increased expression of CXCL1 mRNA

NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215

G

C-X-C motif chemokine ligand 10

decreases expression

beta-Naphthoflavone results in decreased expression of CXCL10 mRNA

NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975

G

C-X-C motif chemokine ligand 11

multiple interactions
increases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CXCL11 mRNA
beta-Naphthoflavone results in increased expression of CXCL11 mRNA

PMID:18164116 PMID:32151702

NCBI chr14:15,689,432...15,692,207
Ensembl chr14:15,689,424...15,692,271

G

C-X-C motif chemokine ligand 12

decreases expression

beta-Naphthoflavone results in decreased expression of CXCL12 mRNA

NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168

G

C-X-C motif chemokine ligand 13

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CXCL13 mRNA

NCBI chr14:13,608,894...13,613,965
Ensembl chr14:13,608,902...13,613,933

G

C-X-C motif chemokine ligand 16

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CXCL16 mRNA

NCBI chr10:55,166,721...55,171,316
Ensembl chr10:55,166,723...55,171,592

G

C-X-C motif chemokine ligand 2

increases expression

beta-Naphthoflavone results in increased expression of CXCL2 mRNA

NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075

G

C-X-C motif chemokine ligand 3

increases expression

beta-Naphthoflavone results in increased expression of CXCL1 mRNA

NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511

G

C-X-C motif chemokine receptor 6

decreases expression

beta-Naphthoflavone results in decreased expression of CXCR6 mRNA

NCBI chr 8:123,434,417...123,439,568
Ensembl chr 8:123,416,325...123,439,526

G

cytochrome b5 type B

decreases expression
multiple interactions

beta-Naphthoflavone results in decreased expression of CYB5B mRNA
AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CYB5B mRNA]

NCBI chr19:35,062,871...35,096,741
Ensembl chr19:35,062,813...35,098,249

G

cytochrome b5 reductase 2

increases expression

beta-Naphthoflavone results in increased expression of CYB5R2 mRNA

NCBI chr 1:161,655,862...161,664,359
Ensembl chr 1:161,655,864...161,664,097

G

cytoplasmic FMR1 interacting protein 2

decreases expression

beta-Naphthoflavone results in decreased expression of CYFIP2 mRNA

NCBI chr10:30,621,318...30,741,113
Ensembl chr10:30,621,318...30,741,113

G

cytoglobin

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYGB mRNA

NCBI chr10:101,877,675...101,887,442
Ensembl chr10:101,877,676...101,887,442

G

cytochrome P450, family 11, subfamily a, polypeptide 1

decreases expression

beta-Naphthoflavone results in decreased expression of CYP11A1 mRNA

NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338

G

cytochrome P450, family 11, subfamily b, polypeptide 2

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of CYP11B1 mRNA
beta-Naphthoflavone promotes the reaction [CYP11B1 protein results in increased chemical synthesis of Hydrocortisone]

NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004

G

cytochrome P450, family 17, subfamily a, polypeptide 1

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in decreased expression of CYP17A1 mRNA

NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573

G

cytochrome P450, family 19, subfamily a, polypeptide 1

increases expression
decreases expression

beta-Naphthoflavone results in increased expression of CYP19A1 mRNA
beta-Naphthoflavone results in decreased expression of CYP19A1 mRNA

PMID:19737606 PMID:32858204

NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758

G

cytochrome P450, family 1, subfamily a, polypeptide 1

decreases activity
increases activity
increases expression
multiple interactions

beta-Naphthoflavone results in decreased activity of CYP1A1 protein
beta-Naphthoflavone results in increased activity of CYP1A1 promoter; beta-Naphthoflavone results in increased activity of CYP1A1 protein
beta-Naphthoflavone results in increased expression of CYP1A1; beta-Naphthoflavone results in increased expression of CYP1A1 mRNA; beta-Naphthoflavone results in increased expression of CYP1A1 protein
3'-methoxy-4'-nitroflavone inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CYP1A1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; beta-Naphthoflavone promotes the reaction [Cycloheximide results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone promotes the reaction [Resveratrol results in increased expression of CYP1A1 protein]; beta-Naphthoflavone results in increased expression of and results in increased activity of CYP1A1 protein; CYP1A2 gene mutant form inhibits the reaction [beta-Naphthoflavone promotes the reaction [Oxygen results in increased expression of CYP1A1 mRNA]]; CYP1A2 gene mutant form inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; CYP1A2 gene mutant form inhibits the reaction [Oxygen promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]]; Resveratrol inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Sorafenib inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Sorafenib inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A1 mRNA; [beta-Naphthoflavone binds to and affects the localization of AHR protein] promotes the reaction [[AHR protein binds to CYP1A1 enhancer] which results in increased expression of CYP1A1 mRNA]; [beta-Naphthoflavone binds to and affects the localization of AHR protein] which results in increased expression of CYP1A1 mRNA; [beta-Naphthoflavone results in increased expression of CYP1A2 protein] inhibits the reaction [CYP1A1 gene mutant form results in increased susceptibility to Oxygen]; [beta-Naphthoflavone results in increased expression of NQO1 protein] inhibits the reaction [CYP1A1 gene mutant form results in increased susceptibility to Oxygen]; Acetylcysteine affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Acetylcysteine affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Acetylcysteine inhibits the reaction [beta-Naphthoflavone results in decreased activity of CYP1A1 protein]; AHR affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; AHR gene alternative form affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; AHR protein affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Apigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Apigenin promotes the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; ARNT affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Arsenic inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Arsenic promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Arsenic promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Ascorbic Acid affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Ascorbic Acid affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone inhibits the reaction [CYP1A1 gene mutant form results in increased susceptibility to Oxygen]; beta-Naphthoflavone promotes the reaction [14-deoxy-11,12-didehydroandrographolide results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone promotes the reaction [[PRL protein co-treated with Dexamethasone] results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone promotes the reaction [andrographolide results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone promotes the reaction [Oxygen results in increased activity of CYP1A1 protein]; beta-Naphthoflavone promotes the reaction [Oxygen results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone promotes the reaction [Oxygen results in increased expression of CYP1A1 protein]; Buthionine Sulfoximine promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Buthionine Sulfoximine promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Butylated Hydroxytoluene affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Cadmium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Cadmium promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Cadmium promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Chromium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Chromium promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Chromium promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; chrysin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Copper inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Copper inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; CTNNB1 gene mutant form affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; CYP1A1 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod]; Dactinomycin inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; FH535 inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; flavanone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; galangin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Glutathione affects the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Glutathione affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Hydrogen Peroxide promotes the reaction [andrographolide affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]]; Hydrogen Peroxide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; kaempferol inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Lead inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Lead inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Lipopolysaccharides inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Luteolin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Mercury inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; morin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; myricetin inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; naringenin promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; neoandrographolide inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Oxygen inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Oxygen inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Oxygen promotes the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Oxygen promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Oxygen promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Quercetin inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Sorafenib inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Sorafenib inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP1A1 mRNA; [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP1A1 protein; [Phenobarbital co-treated with beta-Naphthoflavone] results in increased expression of CYP1A1 protein; AHR protein promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; alpha-naphthoflavone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Amiodarone promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone promotes the reaction [Diethylnitrosamine results in increased expression of CYP1A1 mRNA]; beta-Naphthoflavone results in increased expression of and results in increased activity of CYP1A1 protein; Curcumin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Drugs, Chinese Herbal inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Genistein inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]; Quercetin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Resveratrol inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Silymarin inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]; Tamoxifen inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]

PMID:1358564 PMID:2154339 PMID:3379039 PMID:3929785 PMID:7646562 More...

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

decreases activity
increases activity
multiple interactions
increases expression
increases response to substance

beta-Naphthoflavone results in decreased activity of CYP1A2 protein
beta-Naphthoflavone results in increased activity of CYP1A2 protein
beta-Naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; beta-Naphthoflavone promotes the reaction [CYP1A2 protein affects the metabolism of Thiabendazole]; CYP1A2 gene mutant form inhibits the reaction [beta-Naphthoflavone promotes the reaction [Oxygen results in increased expression of CYP1A1 mRNA]]; CYP1A2 gene mutant form inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; CYP1A2 gene mutant form inhibits the reaction [Oxygen promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 protein]]; CYP1A2 gene mutant form inhibits the reaction [Oxygen promotes the reaction [beta-Naphthoflavone results in increased expression of NQO1 protein]]; CYP1A2 gene mutant form promotes the reaction [beta-Naphthoflavone results in increased expression of NQO1 mRNA]
[2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 protein; [Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 mRNA; [Phenobarbital co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 protein; beta-Naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A2 protein]; beta-Naphthoflavone results in increased expression of and results in increased activity of CYP1A2 protein; diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP1A2 protein]; lead nitrate inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 protein]
beta-Naphthoflavone results in increased expression of CYP1A2 mRNA; beta-Naphthoflavone results in increased expression of CYP1A2 protein
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP1A2 mRNA; [beta-Naphthoflavone results in increased expression of CYP1A2 protein] inhibits the reaction [CYP1A1 gene mutant form results in increased susceptibility to Oxygen]; [beta-Naphthoflavone results in increased expression of CYP1A2 protein] which results in decreased susceptibility to Oxygen; [furafylline results in decreased activity of CYP1A2 protein] promotes the reaction [beta-Naphthoflavone results in increased activity of AHR protein]; Berberine inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA]; beta-Naphthoflavone promotes the reaction [Oxygen results in increased activity of CYP1A2 protein]; beta-Naphthoflavone promotes the reaction [Oxygen results in increased expression of CYP1A2 mRNA]; CTNNB1 gene mutant form inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA]; CYP1A2 protein affects the reaction [beta-Naphthoflavone results in increased metabolism of Imiquimod]; Oxygen inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 protein]; Oxygen promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1A2 mRNA]
CYP1A2 gene mutant form results in increased susceptibility to beta-Naphthoflavone

PMID:2208584 PMID:3038308 PMID:8419313 PMID:8902619 PMID:10463385 More...

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions
increases expression

beta-Naphthoflavone binds to and results in decreased activity of CYP1B1 protein
andrographolide promotes the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA]; Apigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA]; Pregnenolone Carbonitrile inhibits the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA]
beta-Naphthoflavone results in increased expression of CYP1B1 mRNA; beta-Naphthoflavone results in increased expression of CYP1B1 protein
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP1B1 mRNA
beta-Naphthoflavone results in increased expression of CYP1B1; beta-Naphthoflavone results in increased expression of CYP1B1 mRNA

PMID:12623754 PMID:14990334 PMID:16985168 PMID:18164116 PMID:19389873 More...

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

cytochrome P450, family 26, subfamily a, polypeptide 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP26A1 mRNA

NCBI chr 1:235,471,368...235,475,204
Ensembl chr 1:235,471,298...235,475,204

G

cytochrome P450, family 27, subfamily a, polypeptide 1

increases expression

beta-Naphthoflavone results in increased expression of CYP27A1 mRNA

NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551

G

cytochrome P450, family 27, subfamily b, polypeptide 1

increases expression

beta-Naphthoflavone results in increased expression of CYP27B1 mRNA

NCBI chr 7:62,869,340...62,876,242
Ensembl chr 7:62,871,297...62,876,241

G

cytochrome P450, family 2, subfamily a, polypeptide 1

increases expression

beta-Naphthoflavone results in increased expression of CYP2A1 mRNA
beta-Naphthoflavone results in increased expression of CYP2A13 mRNA

PMID:19118567 PMID:22258563

NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887

G

cytochrome P450, family 2, subfamily a, polypeptide 3

multiple interactions

beta-Naphthoflavone promotes the reaction [andrographolide results in increased expression of CYP2A4 mRNA]

NCBI chr 1:82,171,914...82,179,980
Ensembl chr 1:82,169,949...82,179,979

G

cytochrome P450, family 2, subfamily b, polypeptide 1

increases activity
increases expression
multiple interactions

beta-Naphthoflavone results in increased activity of CYP2B1 protein
beta-Naphthoflavone results in increased expression of CYP2B1 mRNA; beta-Naphthoflavone results in increased expression of CYP2B1 protein
beta-Naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP2B1 protein]

PMID:15588932 PMID:15607757 PMID:16054776

NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052

G

cytochrome P450, family 2, subfamily b, polypeptide 2

multiple interactions
decreases expression
increases activity

beta-Naphthoflavone inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased activity of CYP2B2 protein]
beta-Naphthoflavone results in decreased expression of CYP2B2 mRNA
beta-Naphthoflavone results in increased activity of CYP2B2 protein

PMID:16054776 PMID:20607812

NCBI chr 1:81,594,534...81,608,567
Ensembl chr 1:81,594,555...81,608,566

G

cytochrome P450, family 2, subfamily b, polypeptide 3

increases expression
increases activity
multiple interactions

beta-Naphthoflavone results in increased expression of CYP2B6 mRNA
beta-Naphthoflavone results in increased activity of CYP2B6 protein
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of CYP2B10 mRNA

PMID:19118567 PMID:19497361 PMID:19737545 PMID:22258563

NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143

G

cytochrome P450, subfamily 2, polypeptide 11

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP2C mRNA; [Phenobarbital co-treated with beta-Naphthoflavone] results in decreased expression of CYP2C11 protein
beta-Naphthoflavone results in decreased expression of CYP2C18 mRNA

PMID:16985168 PMID:18164116 PMID:30842367

NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066

G

cytochrome P450, family 2, subfamily C, polypeptide 6

decreases expression
multiple interactions

beta-Naphthoflavone results in decreased expression of CYP2C19 mRNA
[Phenobarbital co-treated with beta-Naphthoflavone] results in increased expression of CYP2C6 protein

PMID:16985168 PMID:30842367 PMID:33263786

NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596

G

cytochrome P450, family 2, subfamily c, polypeptide 7

decreases expression
multiple interactions

beta-Naphthoflavone results in decreased expression of CYP2C7 mRNA
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP2C7 mRNA

PMID:18164116 PMID:20607812

NCBI chr 1:237,332,641...237,388,714
Ensembl chr 1:237,332,659...237,388,709

G

cytochrome P450, family 2, subfamily d, polypeptide 4

decreases expression

beta-Naphthoflavone results in decreased expression of CYP2D6 mRNA

NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759

G

cytochrome P450, family 2, subfamily e, polypeptide 1

increases expression
decreases expression
multiple interactions

beta-Naphthoflavone results in increased expression of CYP2E1 mRNA
beta-Naphthoflavone results in decreased expression of CYP2E1 mRNA
[Phenobarbital co-treated with beta-Naphthoflavone] results in decreased expression of CYP2E1 protein
beta-Naphthoflavone results in increased expression of CYP2E1 mRNA; beta-Naphthoflavone results in increased expression of CYP2E1 protein
[CYP2E1 protein co-treated with beta-Naphthoflavone] results in increased expression of KLF6 protein

PMID:19969063 PMID:22258563 PMID:22486562 PMID:30373287 PMID:30842367

NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023

G

cytochrome P450, family 2, subfamily j, polypeptide 3

increases expression

beta-Naphthoflavone results in increased expression of CYP2J3 mRNA

NCBI chr 5:111,219,921...111,244,987
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 2, subfamily j, polypeptide 4

decreases expression

beta-Naphthoflavone results in decreased expression of CYP2J2 mRNA

NCBI chr 5:111,179,981...111,207,490
Ensembl chr 5:111,178,703...111,244,794

G

cytochrome P450, family 2, subfamily s, polypeptide 1

increases expression

beta-Naphthoflavone results in increased expression of CYP2S1 mRNA

NCBI chr 1:81,309,948...81,325,303
Ensembl chr 1:81,310,451...81,325,303

G

cytochrome P450, family 2, subfamily u, polypeptide 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP2U1 mRNA

NCBI chr 2:219,849,403...219,866,959
Ensembl chr 2:219,849,407...219,866,882

G

cytochrome P450, family 2, subfamily w, polypeptide 1

decreases expression

beta-Naphthoflavone results in decreased expression of CYP2W1 mRNA

NCBI chr12:15,291,552...15,296,421
Ensembl chr12:15,291,704...15,296,421

G

cytochrome P450, family 3, subfamily a, polypeptide 2

multiple interactions
increases activity
affects binding
decreases expression
increases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP3A2 mRNA; [Phenobarbital co-treated with beta-Naphthoflavone] results in increased expression of CYP3A2 protein; diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP3A2 protein]
beta-Naphthoflavone binds to CYP3A4 protein
[[beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [beta-Naphthoflavone results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam
beta-Naphthoflavone results in decreased expression of CYP3A4 mRNA
beta-Naphthoflavone results in increased expression of CYP3A4 mRNA

PMID:16837568 PMID:16985168 PMID:18164116 PMID:21053930 PMID:22258563 More...

NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008

G

cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1

decreases expression
increases activity
multiple interactions

beta-Naphthoflavone results in decreased expression of CYP3A23-3A1 mRNA
beta-Naphthoflavone results in increased activity of CYP3A23-3A1 protein
[Phenobarbital co-treated with beta-Naphthoflavone] results in increased expression of CYP3A23-3A1 protein; diphenyleneiodonium inhibits the reaction [beta-Naphthoflavone results in increased activity of CYP3A23-3A1 protein]

PMID:19041297 PMID:26880746 PMID:30842367

NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
Ensembl chr12:9,254,475...9,285,030

G

cytochrome P450, family 3, subfamily a, polypeptide 62

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP3A62 mRNA

NCBI chr12:16,397,998...16,433,833
Ensembl chr12:16,397,998...16,433,833

G

cytochrome P450, family 3, subfamily a, polypeptide 9

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP3A13 mRNA
beta-Naphthoflavone results in decreased expression of CYP3A5 mRNA

PMID:18164116 PMID:33263786

NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422

G

cytochrome P450, family 4, subfamily a, polypeptide 1

increases expression

beta-Naphthoflavone results in increased expression of CYP4A1 mRNA

NCBI chr 5:129,123,323...129,137,464
Ensembl chr 5:129,123,336...129,137,464

G

cytochrome P450, family 4, subfamily a, polypeptide 8

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of CYP4A8 mRNA

NCBI chr 5:128,702,130...128,733,476
Ensembl chr 5:128,702,131...128,733,476

G

cytochrome P450, family 4, subfamily b, polypeptide 1

decreases expression

beta-Naphthoflavone results in decreased expression of CYP4B1 mRNA

PMID:16985168 PMID:22258563

NCBI chr 5:129,139,019...129,176,860
Ensembl chr 5:129,139,038...129,156,348

G

cytochrome P450, family 4, subfamily f, polypeptide 18

increases expression

beta-Naphthoflavone results in increased expression of CYP4F3 mRNA

NCBI chr16:17,763,543...17,804,944
Ensembl chr16:17,707,317...17,804,940

G

cytochrome P450, family 4, subfamily f, polypeptide 4

increases expression

beta-Naphthoflavone results in increased expression of CYP4F4 mRNA

NCBI chr 7:11,717,208...11,733,507
Ensembl chr 7:11,717,208...11,733,506

G

cytochrome P450, family 51

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of CYP51 mRNA
beta-Naphthoflavone results in decreased expression of CYP51 mRNA
AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of CYP51 mRNA]

PMID:18164116 PMID:22234961

NCBI chr 4:30,036,956...30,055,410
Ensembl chr 4:30,036,865...30,055,410

G

cytochrome P450 family 7 subfamily A member 1

decreases expression

beta-Naphthoflavone results in decreased expression of CYP7A1 mRNA

NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688

G

cytochrome P450 family 7 subfamily B member 1

increases expression

beta-Naphthoflavone results in increased expression of CYP7B1 mRNA

NCBI chr 2:100,502,791...100,669,713
Ensembl chr 2:100,502,791...100,669,698

G

drebrin 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DBN1 mRNA

NCBI chr17:9,150,608...9,164,982
Ensembl chr17:9,150,659...9,164,984

G

D-box binding PAR bZIP transcription factor

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DBP mRNA

NCBI chr 1:96,175,796...96,180,745
Ensembl chr 1:96,175,440...96,180,745

G

doublecortin-like kinase 1

multiple interactions
increases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DCLK1 mRNA
beta-Naphthoflavone results in increased expression of DCLK1 mRNA

PMID:18164116 PMID:23994337

NCBI chr 2:139,417,234...139,710,956
Ensembl chr 2:139,417,163...139,710,956

G

decorin

decreases expression

beta-Naphthoflavone results in decreased expression of DCN mRNA

NCBI chr 7:32,281,252...32,321,291
Ensembl chr 7:32,281,252...32,321,270

G

defective in cullin neddylation 1 domain containing 1

increases expression

beta-Naphthoflavone results in increased expression of DCUN1D1 mRNA

NCBI chr 2:118,721,275...118,772,606
Ensembl chr 2:118,721,822...118,772,602

G

dopa decarboxylase

multiple interactions

[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of DDC mRNA

NCBI chr14:86,378,685...86,469,189
Ensembl chr14:86,378,685...86,469,208

G

DNA-damage-inducible transcript 4

increases expression

beta-Naphthoflavone results in increased expression of DDIT4 mRNA

NCBI chr20:27,891,989...27,894,088
Ensembl chr20:27,891,998...27,894,105

G

defensin alpha 3

increases expression

beta-Naphthoflavone results in increased expression of DEFA3 mRNA

NCBI chr16:70,533,436...70,535,592
Ensembl chr16:70,533,436...70,535,604

G

defensin beta 1

decreases expression

beta-Naphthoflavone results in decreased expression of DEFB1 mRNA

NCBI chr16:70,298,862...70,313,604
Ensembl chr16:70,298,863...70,313,604

G

defensin beta 14

increases expression

beta-Naphthoflavone results in increased expression of DEFB103A mRNA

NCBI chr16:70,663,443...70,668,473
Ensembl chr16:70,663,333...70,666,540

G

DENN domain containing 2A

decreases expression

beta-Naphthoflavone results in decreased expression of DENND2A mRNA

NCBI chr 4:68,233,016...68,332,235
Ensembl chr 4:68,233,958...68,332,105

G

DEP domain containing 1B

decreases expression

beta-Naphthoflavone results in decreased expression of DEPDC1B mRNA

NCBI chr 2:39,891,163...39,963,779
Ensembl chr 2:39,891,481...39,963,779

G

DEPP autophagy regulator 1

increases expression

beta-Naphthoflavone results in increased expression of DEPP1 mRNA

NCBI chr 4:149,910,794...149,913,013
Ensembl chr 4:149,910,779...149,914,542

G

Dexi homolog

decreases expression

beta-Naphthoflavone results in decreased expression of DEXI mRNA

NCBI chr10:5,126,021...5,138,746
Ensembl chr10:5,137,288...5,138,738

G

diacylglycerol O-acyltransferase 2

decreases expression

beta-Naphthoflavone results in decreased expression of DGAT2 mRNA

NCBI chr 1:153,454,078...153,484,432
Ensembl chr 1:153,454,080...153,484,428

G

7-dehydrocholesterol reductase

multiple interactions
decreases expression

AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of DHCR7 mRNA]

NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055

G

dehydrogenase/reductase 9

decreases expression

beta-Naphthoflavone results in decreased expression of DHRS9 mRNA

NCBI chr 3:54,147,834...54,170,052
Ensembl chr 3:54,147,803...54,220,241

G

iodothyronine deiodinase 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DIO2 mRNA

NCBI chr 6:109,665,523...109,679,809
Ensembl chr 6:109,665,523...109,679,809

G

dickkopf WNT signaling pathway inhibitor 1

decreases expression

beta-Naphthoflavone results in decreased expression of DKK1 mRNA

NCBI chr 1:228,381,521...228,385,202
Ensembl chr 1:228,381,521...228,385,202

G

deleted in malignant brain tumors 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DMBT1 mRNA

NCBI chr 1:185,617,469...185,696,476
Ensembl chr 1:185,617,294...185,696,478

G

dimethylglycine dehydrogenase

decreases expression
multiple interactions

beta-Naphthoflavone results in decreased expression of DMGDH mRNA
AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of DMGDH mRNA]

NCBI chr 2:24,912,600...24,987,533
Ensembl chr 2:24,912,578...24,987,528

G

dynein, axonemal, heavy chain 9

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of DNAH9 mRNA

NCBI chr10:50,496,174...50,864,909
Ensembl chr10:50,497,688...50,864,949

G

DnaJ heat shock protein family (Hsp40) member B11

increases expression

beta-Naphthoflavone results in increased expression of DNAJB11 mRNA

NCBI chr11:78,151,750...78,168,259
Ensembl chr11:78,150,429...78,180,407

G

dynamin 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DNM1 mRNA

NCBI chr 3:15,604,782...15,648,654
Ensembl chr 3:15,604,784...15,648,538

G

dynamin 1-like

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DNM1L mRNA

NCBI chr11:84,581,216...84,632,382
Ensembl chr11:84,581,216...84,631,482

G

DNA methyltransferase 1

decreases expression

beta-Naphthoflavone results in decreased expression of DNMT1 mRNA

NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659

G

dedicator of cytokinesis 9

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of DOCK9 mRNA

NCBI chr15:98,611,518...98,883,306
Ensembl chr15:98,618,084...98,883,153

G

dipeptidase 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DPEP1 mRNA

NCBI chr19:51,209,831...51,237,004
Ensembl chr19:51,219,660...51,235,257

G

dipeptidylpeptidase 7

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DPP7 mRNA

NCBI chr 3:8,165,091...8,169,343
Ensembl chr 3:8,165,091...8,169,355

G

dystrobrevin, beta

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DTNB mRNA

NCBI chr 6:26,566,418...26,763,467
Ensembl chr 6:26,566,925...26,766,335

G

dual specificity phosphatase 13B

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DUSP13B mRNA

NCBI chr15:2,567,432...2,575,105
Ensembl chr15:2,533,547...2,575,539

G

dual specificity phosphatase 6

increases expression

beta-Naphthoflavone results in increased expression of DUSP6 mRNA

NCBI chr 7:34,092,848...34,097,186
Ensembl chr 7:34,092,943...34,097,185

G

decapping exoribonuclease

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of DXO mRNA

NCBI chr20:3,993,322...3,995,484
Ensembl chr20:3,993,327...3,995,494

G

dynein cytoplasmic 1 heavy chain 1

increases expression

beta-Naphthoflavone results in increased expression of DYNC1H1 mRNA

NCBI chr 6:129,615,208...129,680,888
Ensembl chr 6:129,609,397...129,680,883

G

dysferlin

increases expression

beta-Naphthoflavone results in increased expression of DYSF mRNA

NCBI chr 4:116,490,877...116,690,709
Ensembl chr 4:116,490,616...116,690,709

G

DAZ interacting zinc finger protein 1-like

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of DZIP1L mRNA

NCBI chr 8:100,188,414...100,229,077
Ensembl chr 8:100,194,999...100,228,988

G

Epstein-Barr virus induced 3

decreases expression

beta-Naphthoflavone results in decreased expression of EBI3 mRNA

NCBI chr 9:774,252...787,544
Ensembl chr 9:783,617...787,544

G

EGF containing fibulin extracellular matrix protein 1

decreases expression

beta-Naphthoflavone results in decreased expression of EFEMP1 mRNA

NCBI chr14:102,610,813...102,690,027
Ensembl chr14:102,610,908...102,690,018

G

EGF containing fibulin extracellular matrix protein 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EFEMP2 mRNA

NCBI chr 1:202,781,692...202,789,784
Ensembl chr 1:202,781,665...202,789,414

G

EF-hand domain family, member D1

decreases expression

beta-Naphthoflavone results in decreased expression of EFHD1 mRNA

NCBI chr 9:87,938,259...87,984,917
Ensembl chr 9:87,938,284...87,984,917

G

egl-9 family hypoxia-inducible factor 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EGLN3 mRNA

NCBI chr 6:71,650,297...71,675,766
Ensembl chr 6:71,650,297...71,675,766

G

early growth response 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of EGR1 mRNA

NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766

G

EH-domain containing 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EHD2 mRNA

NCBI chr 1:76,639,568...76,658,747
Ensembl chr 1:76,637,482...76,658,783

G

EH-domain containing 4

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EHD4 mRNA

NCBI chr 3:107,058,191...107,121,985
Ensembl chr 3:107,058,958...107,122,002

G

EP300 interacting inhibitor of differentiation 3

multiple interactions
increases expression

[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of EID3 mRNA
beta-Naphthoflavone results in increased expression of EID3 mRNA

PMID:19737545 PMID:32858204

NCBI chr 7:20,860,073...20,861,395

G

elastin

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ELN mRNA

NCBI chr12:21,968,544...22,011,929
Ensembl chr12:21,968,544...22,011,928

G

ELOVL fatty acid elongase 3

decreases expression

beta-Naphthoflavone results in decreased expression of ELOVL3 mRNA

NCBI chr 1:244,997,287...245,001,115
Ensembl chr 1:244,997,287...245,001,115

G

ELOVL fatty acid elongase 6

decreases expression

beta-Naphthoflavone results in decreased expression of ELOVL6 mRNA

NCBI chr 2:218,063,682...218,174,767
Ensembl chr 2:218,063,804...218,171,186

G

elastin microfibril interfacer 1

increases expression

beta-Naphthoflavone results in increased expression of EMILIN1 mRNA

NCBI chr 6:25,455,974...25,463,713
Ensembl chr 6:25,445,298...25,463,698

G

epithelial membrane protein 1

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EMP1 mRNA
beta-Naphthoflavone results in decreased expression of EMP1 mRNA

PMID:18164116 PMID:32858204

NCBI chr 4:168,212,901...168,233,039
Ensembl chr 4:168,212,861...168,232,904

G

epithelial membrane protein 3

increases expression

beta-Naphthoflavone results in increased expression of EMP3 mRNA

NCBI chr 1:96,388,651...96,391,946
Ensembl chr 1:96,388,652...96,391,988

G

empty spiracles homeobox 2

decreases expression

beta-Naphthoflavone results in decreased expression of EMX2 mRNA

NCBI chr 1:258,626,584...258,633,594
Ensembl chr 1:258,626,584...258,633,594

G

ectodermal-neural cortex 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ENC1 mRNA

NCBI chr 2:28,550,670...28,562,591
Ensembl chr 2:28,550,464...28,562,713

G

ectonucleotide pyrophosphatase/phosphodiesterase family member 5

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ENPP5 mRNA

NCBI chr 9:16,910,187...16,917,633
Ensembl chr 9:16,910,831...16,917,480

G

ectonucleoside triphosphate diphosphohydrolase 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ENTPD2 mRNA

NCBI chr 3:8,213,575...8,219,094
Ensembl chr 3:8,213,663...8,226,866

G

epithelial cell adhesion molecule

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EPCAM mRNA

NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127

G

ependymin related 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EPDR1 mRNA

NCBI chr17:45,333,932...45,358,597
Ensembl chr17:45,333,956...45,358,594

G

epoxide hydrolase 1

decreases activity
increases expression

beta-Naphthoflavone results in decreased activity of EPHX1 protein
beta-Naphthoflavone results in increased expression of EPHX1 mRNA

PMID:3621371 PMID:22258563 PMID:23994337

NCBI chr13:92,714,315...92,744,105
Ensembl chr13:92,714,315...92,790,235

G

elongin BC and polycomb repressive complex 2 associated protein

increases expression

beta-Naphthoflavone results in increased expression of EPOP mRNA

NCBI chr10:82,624,392...82,625,912
Ensembl chr10:82,624,392...82,625,912

G

epidermal growth factor receptor pathway substrate 15

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of EPS15 mRNA

NCBI chr 5:124,045,865...124,146,221
Ensembl chr 5:124,045,926...124,146,221

G

erb-b2 receptor tyrosine kinase 2

decreases expression

beta-Naphthoflavone results in decreased expression of ERBB2 mRNA

NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078

G

endothelial cell adhesion molecule

decreases expression

beta-Naphthoflavone results in decreased expression of ESAM mRNA

NCBI chr 8:37,238,228...37,249,217
Ensembl chr 8:37,238,287...37,249,215

G

endothelial cell-specific molecule 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of ESM1 mRNA

NCBI chr 2:44,876,067...44,884,805
Ensembl chr 2:44,876,067...44,884,804

G

estrogen receptor 1

multiple interactions
affects binding
decreases expression

[alpha-naphthoflavone co-treated with beta-Naphthoflavone] results in decreased expression of ESR1 mRNA
[beta-Naphthoflavone binds to AHR protein] which binds to ESR1 protein
beta-Naphthoflavone results in decreased expression of ESR1 mRNA

PMID:10620335 PMID:20607812 PMID:22975028

NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002

G

estrogen receptor 2

multiple interactions

[alpha-naphthoflavone co-treated with beta-Naphthoflavone] results in decreased expression of ESR2 mRNA

NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919

G

estrogen related receptor, alpha

affects binding

[beta-Naphthoflavone binds to AHR protein] which binds to ESRRA protein

NCBI chr 1:204,104,100...204,114,182
Ensembl chr 1:204,104,101...204,114,268

G

ETS variant transcription factor 5

decreases expression

beta-Naphthoflavone results in decreased expression of ETV5 mRNA

NCBI chr11:78,608,618...78,666,221
Ensembl chr11:78,608,710...78,666,215

G

eva-1 homolog A, regulator of programmed cell death

decreases expression

beta-Naphthoflavone results in decreased expression of EVA1A mRNA

NCBI chr 4:114,593,773...114,643,011
Ensembl chr 4:114,593,341...114,643,011

G

ezrin

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of EZR mRNA

NCBI chr 1:46,967,961...47,011,505
Ensembl chr 1:46,967,658...47,011,505

G

coagulation factor V

decreases expression

beta-Naphthoflavone results in decreased expression of F5 mRNA

NCBI chr13:76,513,509...76,583,106
Ensembl chr13:76,513,255...76,582,317

G

fatty acid binding protein 4

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FABP4 mRNA

NCBI chr 2:91,580,879...91,585,567
Ensembl chr 2:91,580,885...91,585,578

G

fatty acid desaturase 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FADS1 mRNA

NCBI chr 1:206,827,724...206,842,734
Ensembl chr 1:206,827,765...206,842,734

G

family with sequence similarity 43, member A

decreases expression

beta-Naphthoflavone results in decreased expression of FAM43A mRNA

NCBI chr11:70,128,253...70,131,401
Ensembl chr11:70,128,253...70,131,401

G

fatty acyl CoA reductase 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FAR1 mRNA

NCBI chr 1:167,644,622...167,705,868
Ensembl chr 1:167,644,677...167,705,730

G

Fas ligand

multiple interactions

AHR mutant form inhibits the reaction [beta-Naphthoflavone results in increased activity of [FASLG protein binds to FASLG protein]]; beta-Naphthoflavone results in increased activity of [FASLG protein binds to FASLG protein]

NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215

G

fatty acid synthase

decreases expression

beta-Naphthoflavone results in decreased expression of FASN mRNA

NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261

G

filamin binding LIM protein 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FBLIM1 mRNA

NCBI chr 5:153,883,945...153,915,524
Ensembl chr 5:153,883,960...153,913,757

G

fibulin 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FBLN2 mRNA

NCBI chr 4:123,704,289...123,763,857
Ensembl chr 4:123,704,373...123,763,948

G

fibulin 5

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FBLN5 mRNA

NCBI chr 6:120,899,219...120,977,829
Ensembl chr 6:120,899,224...120,977,755

G

fibrillin 2

decreases expression

beta-Naphthoflavone results in decreased expression of FBN2 mRNA

NCBI chr18:51,499,670...51,703,976
Ensembl chr18:51,499,737...51,703,976

G

F-box protein 21

increases expression

beta-Naphthoflavone results in increased expression of FBXO21 mRNA

NCBI chr12:38,570,878...38,605,133
Ensembl chr12:38,571,023...38,605,133

G

F-box protein 25

increases expression

beta-Naphthoflavone results in increased expression of FBXO25 mRNA

NCBI chr16:75,666,062...75,701,770
Ensembl chr16:75,667,904...75,701,696

G

farnesyl diphosphate farnesyl transferase 1

decreases expression
multiple interactions

beta-Naphthoflavone results in decreased expression of FDFT1 mRNA
AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of FDFT1 mRNA]

NCBI chr15:37,412,143...37,440,198
Ensembl chr15:37,412,146...37,440,287

G

farnesyl diphosphate synthase

decreases expression

beta-Naphthoflavone results in decreased expression of FDPS mRNA

NCBI chr 2:174,497,402...174,507,031
Ensembl chr 2:174,486,665...174,507,776

G

ferredoxin 1

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of FDX1 mRNA
beta-Naphthoflavone results in decreased expression of FDX1 mRNA

PMID:18164116 PMID:32858204

NCBI chr 8:52,268,536...52,287,344
Ensembl chr 8:52,268,536...52,287,414

G

fibrinogen beta chain

decreases expression

beta-Naphthoflavone results in decreased expression of FGB mRNA

NCBI chr 2:168,394,901...168,402,863
Ensembl chr 2:168,394,916...168,405,979

G

FYVE, RhoGEF and PH domain containing 5

increases expression

beta-Naphthoflavone results in increased expression of FGD5 mRNA

NCBI chr 4:124,497,061...124,594,564
Ensembl chr 4:124,497,068...124,594,563

G

fibroblast growth factor 21

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of FGF21 mRNA

NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454

G

four and a half LIM domains 1

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FHL1 mRNA
beta-Naphthoflavone results in decreased expression of FHL1 mRNA

PMID:18164116 PMID:32858204

NCBI chr X:134,555,399...134,614,930
Ensembl chr X:134,555,479...134,614,928

G

four and a half LIM domains 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FHL2 mRNA

NCBI chr 9:45,388,979...45,462,421
Ensembl chr 9:45,388,981...45,431,192

G

FKBP prolyl isomerase 5

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FKBP5 mRNA

NCBI chr20:6,457,207...6,575,404
Ensembl chr20:6,457,216...6,541,674

G

filaggrin

decreases expression

beta-Naphthoflavone results in decreased expression of FLG protein

NCBI chr 2:178,884,793...178,912,986

G

filamin C

increases expression

beta-Naphthoflavone results in increased expression of FLNC mRNA

NCBI chr 4:58,034,088...58,061,882
Ensembl chr 4:58,034,189...58,061,844

G

flavin containing dimethylaniline monoxygenase 1

decreases expression

beta-Naphthoflavone results in decreased expression of FMO1 mRNA

NCBI chr13:75,182,184...75,214,439
Ensembl chr13:75,182,176...75,214,647

G

flavin containing dimethylaniline monoxygenase 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FMO2 mRNA

NCBI chr13:75,221,149...75,244,377
Ensembl chr13:75,224,402...75,244,308

G

flavin containing dimethylaniline monoxygenase 5

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FMO5 mRNA
beta-Naphthoflavone results in decreased expression of FMO5 mRNA

PMID:18164116 PMID:22258563

NCBI chr 2:185,197,184...185,249,699
Ensembl chr 2:185,222,204...185,249,693

G

fibronectin type III domain containing 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FNDC1 mRNA

NCBI chr 1:47,281,839...47,364,247
Ensembl chr 1:47,281,844...47,364,259

G

fibronectin type III domain containing 4

increases expression

beta-Naphthoflavone results in increased expression of FNDC4 mRNA

NCBI chr 6:25,077,155...25,080,812
Ensembl chr 6:25,077,349...25,080,675

G

Fos proto-oncogene, AP-1 transcription factor subunit

multiple interactions
increases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FOS mRNA
beta-Naphthoflavone promotes the reaction [FOS protein binds to NQO1 promoter]
AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of FOS protein]; beta-Naphthoflavone results in decreased expression of and results in increased ubiquitination of FOS protein; UBE2L3 protein affects the reaction [beta-Naphthoflavone results in decreased expression of FOS protein]
beta-Naphthoflavone results in increased expression of FOS mRNA

PMID:8375015 PMID:18164116 PMID:26318284 PMID:32151702

NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036

G

FosB proto-oncogene, AP-1 transcription factor subunit

increases expression

beta-Naphthoflavone results in increased expression of FOSB mRNA

NCBI chr 1:78,954,312...78,961,492
Ensembl chr 1:78,954,115...78,961,465

G

FOS like 1, AP-1 transcription factor subunit

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FOSL1 mRNA

NCBI chr 1:202,754,549...202,763,057
Ensembl chr 1:202,754,529...202,764,930

G

frizzled-related protein

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FRZB mRNA
beta-Naphthoflavone results in decreased expression of FRZB mRNA

PMID:18164116 PMID:32858204

NCBI chr 3:65,332,274...65,365,208
Ensembl chr 3:65,332,277...65,365,208

G

fascin actin-bundling protein 1

decreases expression

beta-Naphthoflavone results in decreased expression of FSCN1 mRNA

NCBI chr12:11,597,042...11,610,183
Ensembl chr12:11,597,048...11,610,211

G

follicle stimulating hormone subunit beta

multiple interactions

beta-Naphthoflavone inhibits the reaction [FSHB protein results in increased expression of LHCGR mRNA]

NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370

G

follistatin-like 1

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of FSTL1 mRNA
beta-Naphthoflavone results in decreased expression of FSTL1 mRNA

PMID:18164116 PMID:32858204

NCBI chr11:62,895,391...62,948,581
Ensembl chr11:62,779,783...62,948,677

G

G0/G1switch 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of G0S2 mRNA

NCBI chr13:104,806,351...104,807,263
Ensembl chr13:104,806,156...104,807,451

G

glucose-6-phosphate dehydrogenase

multiple interactions
increases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of G6PD protein
beta-Naphthoflavone results in increased expression of G6PD mRNA

PMID:28903497 PMID:32858204

NCBI chr X:152,201,081...152,220,863
Ensembl chr X:152,201,098...152,220,801

G

GABA type A receptor associated protein like 1

increases expression

beta-Naphthoflavone results in increased expression of GABARAPL1 mRNA

NCBI chr 4:162,980,309...162,989,452
Ensembl chr 4:162,980,249...162,989,450

G

gamma-aminobutyric acid type A receptor subunit gamma 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GABRG1 mRNA

NCBI chr14:37,396,217...37,469,606
Ensembl chr14:37,396,294...37,635,956

G

growth arrest and DNA-damage-inducible, beta

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GADD45B mRNA

NCBI chr 7:8,778,004...8,780,306
Ensembl chr 7:8,778,007...8,780,046

G

polypeptide N-acetylgalactosaminyltransferase 10

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GALNT10 mRNA

NCBI chr10:41,821,216...41,967,618
Ensembl chr10:41,820,158...41,967,013

G

polypeptide N-acetylgalactosaminyltransferase 18

decreases expression

beta-Naphthoflavone results in decreased expression of GALNT18 mRNA

NCBI chr 1:165,593,180...165,904,268
Ensembl chr 1:165,593,187...165,904,268

G

galanin receptor 2

increases expression

beta-Naphthoflavone results in increased expression of GALR2 mRNA

NCBI chr10:101,513,689...101,517,176
Ensembl chr10:101,514,471...101,517,176

G

glyceraldehyde-3-phosphate dehydrogenase

increases expression

beta-Naphthoflavone results in increased expression of GAPDH mRNA

NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235

G

growth arrest-specific 1

decreases expression

beta-Naphthoflavone results in decreased expression of GAS1 mRNA

NCBI chr17:4,482,168...4,485,153

G

GATA binding protein 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GATA3 mRNA

NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391

G

glucosylceramidase beta 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GBA2 mRNA

NCBI chr 5:57,822,389...57,834,522
Ensembl chr 5:57,822,389...57,834,072

G

guanylate binding protein family member 6

decreases expression
multiple interactions

beta-Naphthoflavone results in decreased expression of GBP6 mRNA
AHR protein affects the reaction [beta-Naphthoflavone results in decreased expression of GBP6 mRNA]

NCBI chr14:4,730,286...4,756,508
Ensembl chr14:4,730,453...4,839,062
Ensembl chr14:4,730,453...4,839,062

G

glucagon receptor

decreases expression

beta-Naphthoflavone results in decreased expression of GCGR mRNA

NCBI chr10:105,808,474...105,816,641
Ensembl chr10:105,808,473...105,816,640

G

GTP cyclohydrolase I feedback regulator

decreases expression

beta-Naphthoflavone results in decreased expression of GCHFR mRNA

NCBI chr 3:106,158,046...106,162,080
Ensembl chr 3:106,159,394...106,162,080

G

glucokinase

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GCK mRNA

NCBI chr14:80,785,060...80,829,842
Ensembl chr14:80,785,060...80,826,995

G

glutamate-cysteine ligase, catalytic subunit

increases expression

beta-Naphthoflavone results in increased expression of GCLC mRNA

PMID:16426233 PMID:23994337

NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544

G

glutamate cysteine ligase, modifier subunit

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of GCLM mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GCLM mRNA

PMID:19737545 PMID:19737606 PMID:32858204

NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535

G

glial cells missing transcription factor 1

decreases expression

beta-Naphthoflavone results in decreased expression of GCM1 mRNA

NCBI chr 8:78,925,687...78,938,924
Ensembl chr 8:78,925,687...78,938,924

G

glucosaminyl (N-acetyl) transferase 3, mucin type

increases expression

beta-Naphthoflavone results in increased expression of GCNT3 mRNA

NCBI chr 8:70,689,173...70,696,476
Ensembl chr 8:70,686,844...70,699,562

G

growth differentiation factor 11

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GDF11 mRNA

NCBI chr 7:1,311,732...1,325,211
Ensembl chr 7:1,311,732...1,320,725

G

growth differentiation factor 15

increases expression
decreases expression

beta-Naphthoflavone results in increased expression of GDF15 mRNA
beta-Naphthoflavone results in decreased expression of GDF15 mRNA

PMID:19737606 PMID:32858204

NCBI chr16:18,804,457...18,808,043
Ensembl chr16:18,805,239...18,808,055

G

growth differentiation factor 6

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GDF6 mRNA

NCBI chr 5:22,996,246...23,012,567
Ensembl chr 5:22,996,246...23,012,567

G

growth factor, augmenter of liver regeneration

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GFER mRNA

NCBI chr10:13,718,489...13,721,782
Ensembl chr10:13,718,489...13,720,869

G

growth hormone 1

decreases expression

beta-Naphthoflavone results in decreased expression of GH1 mRNA

NCBI chr10:91,228,102...91,230,079
Ensembl chr10:91,228,103...91,230,078

G

gap junction protein, alpha 5

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GJA5 mRNA

NCBI chr 2:184,602,407...184,621,952
Ensembl chr 2:184,564,475...184,621,952

G

gastrokine 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GKN1 mRNA

NCBI chr 4:119,790,101...119,795,389
Ensembl chr 4:119,790,101...119,795,389

G

galactosidase, alpha

increases expression

beta-Naphthoflavone results in increased expression of GLA mRNA

NCBI chr X:97,769,227...97,780,646
Ensembl chr X:97,768,996...97,780,664

G

gliomedin

decreases expression

beta-Naphthoflavone results in decreased expression of GLDN mRNA

NCBI chr 8:54,679,015...54,723,198
Ensembl chr 8:54,679,119...54,723,196

G

glutaminase 2

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GLS2 mRNA

NCBI chr 7:617,252...633,424
Ensembl chr 7:617,288...633,426

G

glutamate-ammonia ligase

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GLUL mRNA

NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108

G

GDP-mannose 4, 6-dehydratase

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GMDS mRNA

NCBI chr17:32,095,315...32,621,975
Ensembl chr17:32,095,386...32,621,961

G

glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase

decreases expression

beta-Naphthoflavone results in decreased expression of GNE mRNA

NCBI chr 5:58,267,189...58,307,396
Ensembl chr 5:58,267,210...58,307,499

G

G protein subunit gamma 8

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GNG8 mRNA

NCBI chr 1:77,564,512...77,568,371
Ensembl chr 1:77,564,515...77,568,371

G

glucosamine-6-phosphate deaminase 1

decreases expression

beta-Naphthoflavone results in decreased expression of GNPDA1 mRNA

NCBI chr18:30,165,435...30,177,462
Ensembl chr18:30,165,427...30,177,486

G

golgin A3

decreases expression

beta-Naphthoflavone results in decreased expression of GOLGA3 mRNA

NCBI chr12:46,452,409...46,500,509
Ensembl chr12:46,454,870...46,500,509

G

glycerol-3-phosphate acyltransferase, mitochondrial

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GPAM mRNA

NCBI chr 1:254,106,323...254,170,755
Ensembl chr 1:254,106,331...254,142,639

G

G protein-coupled bile acid receptor 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPBAR1 mRNA

NCBI chr 9:75,860,758...75,863,260
Ensembl chr 9:75,860,677...75,863,168

G

glypican 3

multiple interactions
decreases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPC3 mRNA
beta-Naphthoflavone results in decreased expression of GPC3 mRNA

PMID:18164116 PMID:32858204

NCBI chr X:131,868,986...132,236,824
Ensembl chr X:131,868,990...132,236,798

G

glycerol-3-phosphate dehydrogenase 2

decreases expression

beta-Naphthoflavone results in decreased expression of GPD2 mRNA

NCBI chr 3:41,800,552...41,937,729
Ensembl chr 3:41,801,930...41,936,901

G

glycoprotein m6a

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPM6A mRNA

NCBI chr16:36,641,282...36,973,377
Ensembl chr16:36,641,284...36,973,475

G

glycoprotein m6b

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPM6B mRNA

NCBI chr X:28,057,788...28,204,409
Ensembl chr X:28,059,450...28,204,211

G

G protein-coupled receptor 35

increases expression

beta-Naphthoflavone results in increased expression of GPR35 mRNA

NCBI chr 9:93,527,165...93,539,573
Ensembl chr 9:93,527,127...93,539,299

G

G protein-coupled receptor 68

increases expression

beta-Naphthoflavone results in increased expression of GPR68 mRNA

NCBI chr 6:120,135,620...120,166,089
Ensembl chr 6:120,135,436...120,166,089

G

G protein-coupled receptor, class C, group 5, member C

increases expression

beta-Naphthoflavone results in increased expression of GPRC5C mRNA

NCBI chr10:99,886,900...99,908,928
Ensembl chr10:99,887,077...99,908,926

G

glutamic--pyruvic transaminase

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GPT mRNA

NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494

G

glutathione peroxidase 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GPX1 mRNA

NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024

G

glutathione peroxidase 2

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of GPX2 mRNA; beta-Naphthoflavone results in increased expression of GPX2 protein
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPX2 mRNA

PMID:18164116 PMID:19389873 PMID:20045035 PMID:21203749 PMID:22687991

NCBI chr 6:95,493,589...95,496,877
Ensembl chr 6:95,493,589...95,496,877

G

glutathione peroxidase 3

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPX3 mRNA

NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035

G

glutathione peroxidase 6

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GPX6 mRNA

NCBI chr17:43,408,472...43,416,091
Ensembl chr17:43,408,472...43,416,091

G

growth factor receptor bound protein 7

decreases expression

beta-Naphthoflavone results in decreased expression of GRB7 mRNA

NCBI chr10:83,443,387...83,453,057
Ensembl chr10:83,444,004...83,453,052

G

glutamate ionotropic receptor AMPA type subunit 1

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GRIA1 mRNA

NCBI chr10:41,210,713...41,527,283
Ensembl chr10:41,210,713...41,527,283

G

glutamate ionotropic receptor NMDA type subunit associated protein 1

increases expression

beta-Naphthoflavone results in increased expression of GRINA mRNA

NCBI chr 7:107,962,194...107,965,372
Ensembl chr 7:107,962,207...107,965,366

G

glutamate metabotropic receptor 7

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of GRM7 mRNA

NCBI chr 4:143,730,862...144,613,230
Ensembl chr 4:143,731,259...144,612,344

G

gasdermin D

increases expression

beta-Naphthoflavone results in increased expression of GSDMD mRNA

NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055

G

glutathione-disulfide reductase

increases expression

beta-Naphthoflavone results in increased expression of GSR mRNA

NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661

G

glutathione S-transferase alpha 1

decreases expression
multiple interactions
increases expression

beta-Naphthoflavone results in decreased expression of GSTA1 mRNA
beta-Naphthoflavone promotes the reaction [AHR protein binds to GSTA1 promoter]; beta-Naphthoflavone results in increased expression of and results in increased activity of GSTA1 protein
beta-Naphthoflavone results in increased expression of GSTA1 mRNA

PMID:25218365 PMID:33035518

NCBI chr 9:23,703,476...23,720,121
Ensembl chr 9:23,703,477...23,720,121

G

glutathione S-transferase alpha 2

increases expression
increases activity
multiple interactions

beta-Naphthoflavone results in increased expression of GSTA2 mRNA
beta-Naphthoflavone results in increased activity of GSTA2 protein
Copper inhibits the reaction [beta-Naphthoflavone results in increased expression of GSTA2 mRNA]; Copper promotes the reaction [beta-Naphthoflavone results in increased activity of GSTA2 protein]; Lead inhibits the reaction [beta-Naphthoflavone results in increased activity of GSTA2 protein]; Lead inhibits the reaction [beta-Naphthoflavone results in increased expression of GSTA2 mRNA]; Mercury inhibits the reaction [beta-Naphthoflavone results in increased activity of GSTA2 protein]; Mercury promotes the reaction [beta-Naphthoflavone results in increased expression of GSTA2 mRNA]
beta-Naphthoflavone results in increased expression of GSTA2 mRNA; beta-Naphthoflavone results in increased expression of GSTA2 protein

PMID:2049074 PMID:12883083 PMID:15297030 PMID:19695238

NCBI chr 8:79,184,535...79,196,827
Ensembl chr 8:79,184,322...79,196,798

G

glutathione S-transferase alpha 3

increases expression

beta-Naphthoflavone results in increased expression of GSTA3 protein

NCBI chr 9:23,658,574...23,684,240
Ensembl chr 9:23,658,574...23,684,240

G

glutathione S-transferase alpha 4

increases expression

beta-Naphthoflavone results in increased expression of GSTA4 protein

NCBI chr 8:79,066,967...79,084,193
Ensembl chr 8:79,066,934...79,084,182

G

glutathione S-transferase alpha 5

multiple interactions
increases expression

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTA5 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTA5 mRNA]
beta-Naphthoflavone results in increased expression of GSTA5 mRNA; beta-Naphthoflavone results in increased expression of GSTA5 protein

PMID:9794803 PMID:18164116 PMID:19695238 PMID:20045035 PMID:22687991

NCBI chr 8:79,105,561...79,117,472
Ensembl chr 8:79,105,661...79,117,472

G

glutathione S-transferase mu 1

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of GSTM1 mRNA
[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTM1 mRNA; isoquercitrin inhibits the reaction [[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GSTM1 mRNA]

PMID:18164116 PMID:18723825 PMID:20045035 PMID:22687991

NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411

G

glutathione S-transferase mu 2

increases expression
multiple interactions

beta-Naphthoflavone results in increased expression of GSTM2 mRNA
[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM2 mRNA

PMID:19695238 PMID:19737545

NCBI chr 2:195,624,015...195,628,774
Ensembl chr 2:195,544,426...195,628,961

G

glutathione S-transferase mu 4

multiple interactions
increases expression

[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM4 mRNA
beta-Naphthoflavone results in increased expression of GSTM4 mRNA

PMID:19695238 PMID:19737545

NCBI chr 2:195,667,940...195,685,315
Ensembl chr 2:195,680,004...195,685,323

G

glutathione S-transferase, mu 5

multiple interactions
increases expression

[andrographolide co-treated with beta-Naphthoflavone] results in increased expression of GSTM3 mRNA
beta-Naphthoflavone results in increased expression of GSTM3 protein

PMID:9794803 PMID:19737545

NCBI chr 2:195,531,599...195,534,562
Ensembl chr 2:195,531,495...195,534,553

G

glutathione S-transferase pi 1

increases expression

beta-Naphthoflavone results in increased expression of GSTP1 mRNA; beta-Naphthoflavone results in increased expression of GSTP1 protein

PMID:9794803 PMID:19118567 PMID:19695238 PMID:23063670

NCBI chr 1:201,337,762...201,340,230
Ensembl chr 1:201,321,672...201,340,226

G

guanylate cyclase 2C

multiple interactions

[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of GUCY2C mRNA

NCBI chr 4:169,568,505...169,649,092
Ensembl chr 4:169,568,529...169,649,092