Msra (methionine sulfoxide reductase A) - Rat Genome Database
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Gene: Msra (methionine sulfoxide reductase A) Rattus norvegicus
Analyze
Symbol: Msra
Name: methionine sulfoxide reductase A
RGD ID: 70979
Description: Exhibits peptide-methionine (S)-S-oxide reductase activity. Involved in aging. Localizes to mitochondrion. Orthologous to human MSRA (methionine sulfoxide reductase A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC93315; mitochondrial peptide methionine sulfoxide reductase; peptide Met(O) reductase; peptide methionine sulfoxide reductase; peptide-methionine (S)-S-oxide reductase; PMSR; protein-methionine-S-oxide reductase
Orthologs:
Homo sapiens (human) : MSRA (methionine sulfoxide reductase A)  HGNC  Alliance
Mus musculus (house mouse) : Msra (methionine sulfoxide reductase A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msra (methionine sulfoxide reductase A)
Pan paniscus (bonobo/pygmy chimpanzee) : MSRA (methionine sulfoxide reductase A)
Canis lupus familiaris (dog) : MSRA (methionine sulfoxide reductase A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msra (methionine sulfoxide reductase A)
Sus scrofa (pig) : MSRA (methionine sulfoxide reductase A)
Chlorocebus sabaeus (African green monkey) : MSRA (methionine sulfoxide reductase A)
more info ...
Allele / Splice: Msraem3Mcwi   Msraem4Mcwi  
Genetic Models: SS-Msraem4Mcwi SS-Msraem3Mcwi
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01547,488,333 - 47,800,662 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,488,894 - 47,800,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01551,307,920 - 51,550,758 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41543,509,775 - 43,756,283 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11543,543,986 - 43,771,983 (-)NCBI
Celera1538,127,708 - 38,353,451 (-)NCBICelera
Cytogenetic Map15p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
actin cytoskeleton  (IEA,ISO)
cytoplasm  (IBA,IDA,ISO)
cytosol  (IEA,ISO)
intercellular bridge  (IEA,ISO)
mitochondrion  (IDA,ISO)
nuclear body  (IEA,ISO)
nucleoplasm  (ISO)

Molecular Function

References

Additional References at PubMed
PMID:11606777   PMID:12477932   PMID:14745014   PMID:15489334   PMID:18083115   PMID:18614015   PMID:19056867   PMID:19085252   PMID:19646993   PMID:20368336   PMID:21726174   PMID:23036869  
PMID:23376485   PMID:24120970   PMID:24315642   PMID:25602783   PMID:30717164  


Genomics

Comparative Map Data
Msra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01547,488,333 - 47,800,662 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1547,488,894 - 47,800,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01551,307,920 - 51,550,758 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41543,509,775 - 43,756,283 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11543,543,986 - 43,771,983 (-)NCBI
Celera1538,127,708 - 38,353,451 (-)NCBICelera
Cytogenetic Map15p12NCBI
MSRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl810,054,292 - 10,428,891 (+)EnsemblGRCh38hg38GRCh38
GRCh38810,054,224 - 10,428,891 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3789,911,830 - 10,286,401 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3689,949,236 - 10,323,805 (+)NCBINCBI36hg18NCBI36
Build 3489,949,235 - 10,323,803NCBI
Celera89,038,143 - 9,413,201 (+)NCBI
Cytogenetic Map8p23.1NCBI
HuRef88,840,844 - 9,216,822 (+)NCBIHuRef
CHM1_189,977,344 - 10,352,199 (+)NCBICHM1_1
Msra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391464,360,070 - 64,693,352 (-)NCBI
GRCm381464,122,621 - 64,455,903 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1464,122,625 - 64,455,903 (-)EnsemblGRCm38mm10GRCm38
MGSCv371464,741,462 - 65,074,740 (-)NCBIGRCm37mm9NCBIm37
MGSCv361463,076,735 - 63,410,013 (-)NCBImm8
Celera1461,900,138 - 62,232,246 (-)NCBICelera
Cytogenetic Map14D1NCBI
cM Map1433.36NCBI
Msra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540351,730,156 - 52,071,269 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540351,729,753 - 52,071,269 (+)NCBIChiLan1.0ChiLan1.0
MSRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Mhudiblu_PPA_v088,751,846 - 9,163,355 (-)NCBIMhudiblu_PPA_v0panPan3
MSRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2527,609,349 - 28,043,271 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12527,608,987 - 28,043,461 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Msra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366752,104,618 - 2,432,033 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MSRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1413,335,420 - 13,778,619 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11413,334,731 - 13,718,914 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21414,869,083 - 15,060,689 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MSRA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl88,663,034 - 8,993,433 (-)Ensembl
ChlSab1.188,664,040 - 9,026,632 (-)NCBI

Position Markers
D15Got43  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01547,791,819 - 47,791,986NCBIRnor6.0
Rnor_5.01551,542,543 - 51,542,710UniSTSRnor5.0
RGSC_v3.41543,748,067 - 43,748,235RGDRGSC3.4
RGSC_v3.41543,748,068 - 43,748,235UniSTSRGSC3.4
RGSC_v3.11543,763,768 - 43,763,935RGD
Celera1538,345,236 - 38,345,403UniSTS
Cytogenetic Map15p12UniSTS
RH 3.4 Map15289.9UniSTS
RH 3.4 Map15289.9RGD
RH 2.0 Map15261.3RGD
D15Got44  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01547,660,913 - 47,661,137NCBIRnor6.0
Rnor_5.01551,412,733 - 51,412,957UniSTSRnor5.0
RGSC_v3.41543,615,579 - 43,615,804RGDRGSC3.4
RGSC_v3.41543,615,580 - 43,615,804UniSTSRGSC3.4
RGSC_v3.11543,631,279 - 43,631,504RGD
Celera1538,214,714 - 38,214,938UniSTS
Cytogenetic Map15p12UniSTS
RH 2.0 Map15261.4RGD
D15Got227  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01547,770,514 - 47,770,728NCBIRnor6.0
Rnor_5.01551,521,238 - 51,521,452UniSTSRnor5.0
RGSC_v3.41543,725,663 - 43,725,877UniSTSRGSC3.4
Celera1538,323,317 - 38,323,531UniSTS
Cytogenetic Map15p12UniSTS
RH137586  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15p12UniSTS
AU048707  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01547,740,442 - 47,740,619NCBIRnor6.0
Rnor_5.01551,491,166 - 51,491,343UniSTSRnor5.0
RGSC_v3.41543,695,214 - 43,695,391UniSTSRGSC3.4
Celera1538,293,281 - 38,293,462UniSTS
Cytogenetic Map15p12UniSTS
AU049139  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.01547,781,415 - 47,781,561NCBIRnor6.0
Rnor_5.01551,532,139 - 51,532,285UniSTSRnor5.0
RGSC_v3.41543,736,565 - 43,736,711UniSTSRGSC3.4
Cytogenetic Map15p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15388113148881131Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151071919155719191Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151549236072568189Rat
9590272Scort14Serum corticosterone level QTL 142.780.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)151698090761980907Rat
8694427Bw163Body weight QTL 1634.820.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)151698090761980907Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151724964162249641Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151724964162249641Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151809320881255430Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151851391388036354Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)152102134252831189Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1526381041106550657Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1526381041106550657Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1526381041106550657Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152870974173709741Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)153321910189640841Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)153321910189640841Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)153321910189640841Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)153321910189640841Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)153948079762596410Rat
2293686Bmd36Bone mineral density QTL 367.40.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)153974955779033707Rat
2293691Bmd37Bone mineral density QTL 376.60.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)153974955779033707Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154106809486068094Rat
7411725Strs7Sensitivity to stroke QTL 73.8cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)154275724156027084Rat
2306968Anxrr23Anxiety related response QTL 234.83reflex trait (VT:0001961)amplitude of the acoustic startle response (CMO:0001520)154309747052831189Rat
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1543097470106550657Rat


Genetic Models
This gene Msra is modified in the following models/strains
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:288
Count of miRNA genes:91
Interacting mature miRNAs:100
Transcripts:ENSRNOT00000016616, ENSRNOT00000071197, ENSRNOT00000072997
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 28 40 25 7 25 1 3 68 35 15 11 1
Low 15 17 16 12 16 7 8 6 26 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_053307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008770745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AABR07018222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AABR07018223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01083431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01083432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01083433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01083434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01083435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01083436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01083437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AAHX01083438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY005464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ989019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ989020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ989021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000016616   ⟹   ENSRNOP00000016616
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1547,488,928 - 47,800,024 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000072997   ⟹   ENSRNOP00000067242
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1547,488,894 - 47,800,024 (-)Ensembl
RefSeq Acc Id: NM_053307   ⟹   NP_445759
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01547,488,333 - 47,800,034 (-)NCBI
Rnor_5.01551,307,920 - 51,550,758 (-)NCBI
RGSC_v3.41543,509,775 - 43,756,283 (-)RGD
Celera1538,127,708 - 38,353,451 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008770745   ⟹   XP_008768967
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01547,488,333 - 47,800,662 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_445759   ⟸   NM_053307
- UniProtKB: Q923M1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008768967   ⟸   XM_008770745
- Peptide Label: isoform X1
- UniProtKB: Q923M1 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000067242   ⟸   ENSRNOT00000072997
RefSeq Acc Id: ENSRNOP00000016616   ⟸   ENSRNOT00000016616
Protein Domains
PMSR

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699784
Promoter ID:EPDNEW_R10308
Type:initiation region
Name:Msra_1
Description:methionine sulfoxide reductase A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01547,800,066 - 47,800,126EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70979 AgrOrtholog
Ensembl Genes ENSRNOG00000012440 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000016616 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000067242 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016616 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000072997 UniProtKB/TrEMBL
Gene3D-CATH 3.30.1060.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7107102 IMAGE-MGC_LOAD
InterPro Met_Sox_Rdtase_MsrA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Met_Sox_Rdtase_MsrA_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29447 UniProtKB/Swiss-Prot
MGC_CLONE MGC:93315 IMAGE-MGC_LOAD
NCBI Gene 29447 ENTREZGENE
Pfam PMSR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Msra PhenoGen
Superfamily-SCOP SSF55068 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs msrA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene Rn.163306 ENTREZGENE
UniProt F1LSJ6_RAT UniProtKB/TrEMBL
  M0RCC8_RAT UniProtKB/TrEMBL
  MSRA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary A9LAT3 UniProtKB/Swiss-Prot
  A9LAT4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Msra  methionine sulfoxide reductase A      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression may decrease with age 70794