Msra (methionine sulfoxide reductase A)

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Gene: Msra (methionine sulfoxide reductase A) Rattus norvegicus

Analyze

Symbol:

Msra

Name:

methionine sulfoxide reductase A

RGD ID:

70979

Description:

Exhibits peptide-methionine (S)-S-oxide reductase activity. Involved in aging. Localizes to mitochondrion. Orthologous to human MSRA (methionine sulfoxide reductase A); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

MGC93315; mitochondrial peptide methionine sulfoxide reductase; peptide Met(O) reductase; peptide methionine sulfoxide reductase; peptide-methionine (S)-S-oxide reductase; PMSR; protein-methionine-S-oxide reductase

Orthologs:

Homo sapiens (human) : MSRA (methionine sulfoxide reductase A) HGNC Alliance
Mus musculus (house mouse) : Msra (methionine sulfoxide reductase A) MGI Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msra (methionine sulfoxide reductase A)
Pan paniscus (bonobo/pygmy chimpanzee) : MSRA (methionine sulfoxide reductase A)
Canis lupus familiaris (dog) : MSRA (methionine sulfoxide reductase A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msra (methionine sulfoxide reductase A)
Sus scrofa (pig) : MSRA (methionine sulfoxide reductase A)
Chlorocebus sabaeus (African green monkey) : MSRA (methionine sulfoxide reductase A)

more info ...

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MSRA (methionine sulfoxide reductase A)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Msra (methionine sulfoxide reductase A)	HGNC	Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Msra (methionine sulfoxide reductase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MSRA (methionine sulfoxide reductase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MSRA (methionine sulfoxide reductase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Msra (methionine sulfoxide reductase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MSRA (methionine sulfoxide reductase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	MSRA (methionine sulfoxide reductase A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Msra (methionine sulfoxide reductase A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Homo sapiens (human):	MSRA (methionine sulfoxide reductase A)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Danio rerio (zebrafish):	msra (methionine sulfoxide reductase A)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	MXR1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|TreeFam)
Drosophila melanogaster (fruit fly):	Eip71CD	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector)
Caenorhabditis elegans (roundworm):	msra-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoInspector)

Allele / Splice:

Msra^em3Mcwi Msra^em4Mcwi

Genetic Models:

SS-Msra^em4Mcwi SS-Msra^em3Mcwi

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

NCBI Annotation Information:

Annotation category: suggests misassembly; Annotation category: partial on reference assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	15	47,488,333 - 47,800,662 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	47,488,894 - 47,800,024 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	51,307,920 - 51,550,758 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	43,509,775 - 43,756,283 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	15	43,543,986 - 43,771,983 (-)	NCBI
Celera	15	38,127,708 - 38,353,451 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autistic disorder (ISO)

Neurodevelopmental Disorders (ISO)

schizophrenia (ISO)

substance-related disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-diaminodiphenylmethane (ISO)

5-aza-2'-deoxycytidine (ISO)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

beta-naphthoflavone (EXP)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP)

butanal (ISO)

cadmium sulfide (ISO)

carbamazepine (ISO)

carbon atom (ISO)

cerium trichloride (ISO)

chloramine T (ISO)

chromium(6+) (ISO)

cisplatin (EXP,ISO)

copper(II) sulfate (ISO)

dioxygen (EXP)

elemental carbon (ISO)

gentamycin (EXP)

methapyrilene (ISO)

N-nitrosodiethylamine (EXP)

N-Nitrosopyrrolidine (ISO)

nickel atom (ISO)

nicotinamide (ISO)

O-methyleugenol (ISO)

ochratoxin A (EXP)

oxaliplatin (EXP)

paracetamol (ISO)

propanal (ISO)

reactive oxygen species (EXP)

resveratrol (ISO)

S-methylcysteine (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

thioacetamide (EXP)

topotecan (EXP)

tunicamycin (ISO)

valproic acid (ISO)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aging (IDA,IEP)

cellular response to oxidative stress (IBA)

oxidation-reduction process (IEA)

Cellular Component

actin cytoskeleton (IEA,ISO)

cytoplasm (IBA,IDA,ISO)

cytosol (IEA,ISO)

intercellular bridge (IEA,ISO)

mitochondrion (IDA,ISO)

nuclear body (IEA,ISO)

nucleoplasm (ISO)

Molecular Function

L-methionine-(S)-S-oxide reductase activity (IBA)

peptide-methionine (S)-S-oxide reductase activity (IBA,IDA,IEA,ISO)

protein binding (ISO)

References

References - curated


1.	Bulvik B, etal., Mech Ageing Dev. 2009 Mar;130(3):139-44. Epub 2008 Oct 17.
2.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	GOA data from the GO Consortium
4.	Haenold R, etal., Free Radic Res. 2007 Nov;41(11):1233-45.
5.	MGD Curation, June 12, 2002
6.	MGD data from the GO Consortium
7.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Petropoulos I, etal., Biochem J 2001 May 1;355(Pt 3):819-25.
9.	RGD automated data pipeline
10.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11606777	PMID:12477932	PMID:14745014	PMID:15489334	PMID:18083115	PMID:18614015	PMID:19056867	PMID:19085252	PMID:19646993	PMID:20368336	PMID:21726174	PMID:23036869
PMID:23376485	PMID:24120970	PMID:24315642	PMID:25602783	PMID:30717164

Genomics

Comparative Map Data

Msra
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	15	47,488,333 - 47,800,662 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	47,488,894 - 47,800,024 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	51,307,920 - 51,550,758 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	43,509,775 - 43,756,283 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	15	43,543,986 - 43,771,983 (-)	NCBI
Celera	15	38,127,708 - 38,353,451 (-)	NCBI		Celera
Cytogenetic Map	15	p12	NCBI

MSRA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	8	10,054,292 - 10,428,891 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	8	10,054,224 - 10,428,891 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	8	9,911,830 - 10,286,401 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	8	9,949,236 - 10,323,805 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	8	9,949,235 - 10,323,803	NCBI
Celera	8	9,038,143 - 9,413,201 (+)	NCBI
Cytogenetic Map	8	p23.1	NCBI
HuRef	8	8,840,844 - 9,216,822 (+)	NCBI		HuRef
CHM1_1	8	9,977,344 - 10,352,199 (+)	NCBI		CHM1_1

Msra
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	64,360,070 - 64,693,352 (-)	NCBI
GRCm38	14	64,122,621 - 64,455,903 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	64,122,625 - 64,455,903 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	64,741,462 - 65,074,740 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	14	63,076,735 - 63,410,013 (-)	NCBI			mm8
Celera	14	61,900,138 - 62,232,246 (-)	NCBI		Celera
Cytogenetic Map	14	D1	NCBI
cM Map	14	33.36	NCBI

Msra
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955403	51,730,156 - 52,071,269 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955403	51,729,753 - 52,071,269 (+)	NCBI	ChiLan1.0	ChiLan1.0

MSRA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Mhudiblu_PPA_v0	8	8,751,846 - 9,163,355 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

MSRA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	25	27,609,349 - 28,043,271 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	25	27,608,987 - 28,043,461 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Msra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936675	2,104,618 - 2,432,033 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MSRA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	13,335,420 - 13,778,619 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	13,334,731 - 13,718,914 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	14,869,083 - 15,060,689 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MSRA
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	8	8,663,034 - 8,993,433 (-)	Ensembl
ChlSab1.1	8	8,664,040 - 9,026,632 (-)	NCBI

Position Markers

D15Got43

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	15	47,791,819 - 47,791,986	NCBI	Rnor6.0
Rnor_5.0	15	51,542,543 - 51,542,710	UniSTS	Rnor5.0
RGSC_v3.4	15	43,748,067 - 43,748,235	RGD	RGSC3.4
RGSC_v3.4	15	43,748,068 - 43,748,235	UniSTS	RGSC3.4
RGSC_v3.1	15	43,763,768 - 43,763,935	RGD
Celera	15	38,345,236 - 38,345,403	UniSTS
Cytogenetic Map	15	p12	UniSTS
RH 3.4 Map	15	289.9	UniSTS
RH 3.4 Map	15	289.9	RGD
RH 2.0 Map	15	261.3	RGD

D15Got44

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	15	47,660,913 - 47,661,137	NCBI	Rnor6.0
Rnor_5.0	15	51,412,733 - 51,412,957	UniSTS	Rnor5.0
RGSC_v3.4	15	43,615,579 - 43,615,804	RGD	RGSC3.4
RGSC_v3.4	15	43,615,580 - 43,615,804	UniSTS	RGSC3.4
RGSC_v3.1	15	43,631,279 - 43,631,504	RGD
Celera	15	38,214,714 - 38,214,938	UniSTS
Cytogenetic Map	15	p12	UniSTS
RH 2.0 Map	15	261.4	RGD

D15Got227

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	15	47,770,514 - 47,770,728	NCBI	Rnor6.0
Rnor_5.0	15	51,521,238 - 51,521,452	UniSTS	Rnor5.0
RGSC_v3.4	15	43,725,663 - 43,725,877	UniSTS	RGSC3.4
Celera	15	38,323,317 - 38,323,531	UniSTS
Cytogenetic Map	15	p12	UniSTS

RH137586

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	15	p12	UniSTS

AU048707

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	15	47,740,442 - 47,740,619	NCBI	Rnor6.0
Rnor_5.0	15	51,491,166 - 51,491,343	UniSTS	Rnor5.0
RGSC_v3.4	15	43,695,214 - 43,695,391	UniSTS	RGSC3.4
Celera	15	38,293,281 - 38,293,462	UniSTS
Cytogenetic Map	15	p12	UniSTS

AU049139

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	15	47,781,415 - 47,781,561	NCBI	Rnor6.0
Rnor_5.0	15	51,532,139 - 51,532,285	UniSTS	Rnor5.0
RGSC_v3.4	15	43,736,565 - 43,736,711	UniSTS	RGSC3.4
Cytogenetic Map	15	p12	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	62301382	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2327877	53535766	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	3881131	48881131	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	10719191	55719191	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	15492360	72568189	Rat
9590272	Scort14	Serum corticosterone level QTL 14	2.78	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	16980907	61980907	Rat
8694427	Bw163	Body weight QTL 163	4.82	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	15	16980907	61980907	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	17249641	62249641	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	17249641	62249641	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	17249641	62249641	Rat
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	18093208	81255430	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	18513913	88036354	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	21021342	52831189	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	26381041	106550657	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	26381041	106550657	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	26381041	106550657	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	28709741	73709741	Rat
1582214	Stl21	Serum triglyceride level QTL 21	3.1	0.022	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	15	33219101	89640841	Rat
1582227	Gluco30	Glucose level QTL 30	3.6	0.0003	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	15	33219101	89640841	Rat
1582228	Epfw3	Epididymal fat weight QTL 3	4.1	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	33219101	89640841	Rat
1582242	Gluco28	Glucose level QTL 28	3.3	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	15	33219101	89640841	Rat
1582244	Bw79	Body weight QTL 79	4	0.0002	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	15	33219101	89640841	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	39480797	62596410	Rat
2293686	Bmd36	Bone mineral density QTL 36	7.4	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	15	39749557	79033707	Rat
2293691	Bmd37	Bone mineral density QTL 37	6.6	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	15	39749557	79033707	Rat
1598828	Glom14	Glomerulus QTL 14	2.5		kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	15	41068094	86068094	Rat
7411725	Strs7	Sensitivity to stroke QTL 7	3.8		cerebrum integrity trait (VT:0010549)	percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)	15	42757241	56027084	Rat
2306968	Anxrr23	Anxiety related response QTL 23	4.83		reflex trait (VT:0001961)	amplitude of the acoustic startle response (CMO:0001520)	15	43097470	52831189	Rat
1300144	Rf23	Renal function QTL 23	3.61		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	15	43097470	106550657	Rat

Genetic Models

This gene Msra is modified in the following models/strains

SS-Msra^em4Mcwi

SS-Msra^em3Mcwi

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	288
Count of miRNA genes:	91
Interacting mature miRNAs:	100
Transcripts:	ENSRNOT00000016616, ENSRNOT00000071197, ENSRNOT00000072997
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	28	40	25	7	25	1	3	68	35	15	11	1
Low		15	17	16	12	16	7	8	6		26		7
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053307	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770745	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07018222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07018223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01083431	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01083432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01083433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01083434	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01083435	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01083436	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01083437	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01083438	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AY005464	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474023	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ989019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ989020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ989021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000016616 ⟹ ENSRNOP00000016616

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	15	47,488,928 - 47,800,024 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000072997 ⟹ ENSRNOP00000067242

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	15	47,488,894 - 47,800,024 (-)	Ensembl

RefSeq Acc Id:

NM_053307 ⟹ NP_445759

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	47,488,333 - 47,800,034 (-)	NCBI
Rnor_5.0	15	51,307,920 - 51,550,758 (-)	NCBI
RGSC_v3.4	15	43,509,775 - 43,756,283 (-)	RGD
Celera	15	38,127,708 - 38,353,451 (-)	NCBI

Sequence:

show sequence

CACGCTGTCCATGCTCTCCGCCTCCAGAAGGACTCTCCAGCTCCTCTCCAGCTCCATCCCGGTA
CGGATGATGGGCGACTCATCTTCGAAGGTCATCAGCGCGGAGGAAGCTTTGCCAGGACGCACAG
AGTCGATCCCCGTAGCAGCCAAACACCATGTCAGTGGCAACAGAACGGTTGAACCTTTCCCAGA
GGGAACACAGATGGCTGTATTTGGAATGGGCTGCTTCTGGGGAGCTGAGCGCAAGTTCTGGCTC
TTGAAAGGAGTGTATTCAACCCAAGTGGGTTTCGCAGGAGGCTACACACGCAATCCCACCTACA
AAGAGGTCTGCTCAGAAAAAACCGGTCACGCAGAAGTCGTCCGGGTTGTGTACCGGCCAGAGCA
CGTCAGCTTTGAGGAGCTGCTCAAGGTCTTCTGGGAGAATCACGACCCGACCCAAGGGATGCGC
CAAGGCAATGACTGTGGCACGCAGTATCGATCGGCGGTCTATCCCACCTCCGCCGTGCAGATGG
AAGCTGCCCTGAAATCCAAGGAGGAGTACCAGAAGGTTCTTTCAAAGCATGGCTTTGGCCCCAT
CACCACCGACATCCGAGAGGGACAAGTGTTCTACTACGCCGAAGATTACCACCAGCAATACCTG
AGCAAGAACCCAGACGGCTACTGTGGCCTTGGGGGCACTGGGGTTTCCTGTCCCACGGCCATTA
AAAAGTAATTTCTCTCCACGAAGCTGGCCCTGGAGGTTCCATCAACACCATGATTGCTGGATGG
AGCAGCACTGCTGTGATTCCCATCTGTCACTTTATGAAGAGCACACACCACACGGGCATTTACA
TGAATCTGGTTGTTATCCGGGTCTGATTTACAGAAAGTAGGATGACGAGGTGATGCGTTGTAAT
TTGTCTTCTGATCAGTCGGGATGGGGATAGAACATGTTTTAGTGGATCATTTGGGGTCTAAATG
AAGATAACGAATATCCTGTGTCCATCTGCTGGAGCCGGAGGGATGCTAAGGGTTCTGAAACAGG
GAGCTGGCTGGGAGAGCACGGAGCACTGGGACTCTAGGGCTGACATACCTCGCCCACCTCCCTG
CCCTCAGGTGCCTAATTCATTAGTGTCTAGGAGCTCCACGAATCATTGCCGAAACACTTTGCTC
TGCTGCCTCTAGACGCATATTAGGGGTTTCTCTCCCCCCTCCGTCCTCTCTGTGCAGAGAAAAG
ACATGAGTGACCTTAATGAATTCTAACATTCTGCTTACAGCTATGATAAAGCTTGTTCTAATAA
AAATCTACGGTTTGGTGATAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAA

hide sequence

RefSeq Acc Id:

XM_008770745 ⟹ XP_008768967

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	47,488,333 - 47,800,662 (-)	NCBI

Sequence:

show sequence

GTGGGTGCTAATCCTTAGTTCCTTCCTTCATATGAAACTATCCGCCCATTTTGGCAGTGTGTAA
TCCAAAATCTCAGAGGACCTCTGAAATCACTCATCTAGTCCTAGCCACCTAAAGATTAAGGCTG
GTGATTTGGTTTAGGAATATTCTTTCATAGTTTCAGAAGTCTGATCCAACTTCACCATTAATTT
CACATAAACAGCGTTATGTGGGCTGAAGAACGTATTTATACATTTATACACACACGCACACTAT
ATATATAGTTCACGTTGAGATCATTTGTGGTGTGGTGTGCTTTGGTTTTTCACTTTGGATCGAT
TCAATTTATCAAGATGGTCCCGAAAGAAACAAATGTCCTAGCTGTCCATCTATTCATCCTTTTA
TAGGTCTGCCTTTCTTCTACTTCGCTGCCTTTTTATGCACACACATTGATTTCCCTTTTCTACT
TGTGGTTGAGTGAGTACATCGCACCCGGAACCCTGGATGAGGAGGTGGGGAAACGGCAGGAACT
CTAACTCCCCGTGGTGGCGCCCAGCCAGCATAAATTTTGGCCCGCGCCGCTTCACGTACTCTGG
GAACTTTGTCCCTCAGAGACAGCCGGGCCTGGAGGTCTGCCCGCGAGACGGACACGCTGTCCAT
GCTCTCCGCCTCCAGAAGGACTCTCCAGCTCCTCTCCAGCTCCATCCCGGTACGGATGATGGGC
GACTCATCTTCGAAGGTCATCAGCGCGGAGGAAGCTTTGCCAGGACGCACAGAGTCGATCCCCG
TAGCAGCCAAACACCATGTCAGTGGCAACAGAACGGTTGAACCTTTCCCAGAGGGAACACAGAT
GGCTGTATTTGGAATGGGCTGCTTCTGGGGAGCTGAGCGCAAGTTCTGGCTCTTGAAAGGAGTG
TATTCAACCCAAGTGGGTTTCGCAGGAGGCTACACACGCAATCCCACCTACAAAGAGGTCTGCT
CAGAAAAAACCGGTCACGCAGAAGTCGTCCGGGTTGTGTACCGGCCAGAGCACGTCAGCTTTGA
GGAGCTGCTCAAGGTCTTCTGGGAGAATCACGACCCGACCCAAGGGATGCGCCAAGGCAATGAC
TGTGGCACGCAGTATCGATCGGCGGTCTATCCCACCTCCGCCGTGCAGATGGAAGCTGCCCTGA
AATCCAAGGAGGAGTACCAGAAGGTTCTTTCAAAGCATGGCTTTGGCCCCATCACCACCGACAT
CCGAGAGGGACAAGTGTTCTACTACGCCGAAGATTACCACCAGCAATACCTGAGCAAGAACCCA
GACGGCTACTGTGGCCTTGGGGGCACTGGGGTTTCCTGTCCCACGGCCATTAAAAAGTAATTTC
TCTCCACGAAGCTGGCCCTGGAGGTTCCATCAACACCATGATTGCTGGATGGAGCAGCACTGCT
GTGATTCCCATCTGTCACTTTATGAAGAGCACACACCACACGGGCATTTACATGAATCTGGTTG
TTATCCGGGTCTGATTTACAGAAAGTAGGATGACGAGGTGATGCGTTGTAATTTGTCTTCTGAT
CAGTCGGGATGGGGATAGAACATGTTTTAGTGGATCATTTGGGGTCTAAATGAAGATAACGAAT
ATCCTGTGTCCATCTGCTGGAGCCGGAGGGATGCTAAGGGTTCTGAAACAGGGAGCTGGCTGGG
AGAGCACGGAGCACTGGGACTCTAGGGCTGACATACCTCGCCCACCTCCCTGCCCTCAGGTGCC
TAATTCATTAGTGTCTAGGAGCTCCACGAATCATTGCCGAAACACTTTGCTCTGCTGCCTCTAG
ACGCATATTAGGGGTTTCTCTCCCCCCTCCGTCCTCTCTGTGCAGAGAAAAGACATGATGACCT
TAAGAATTCTAACATTCTGCTTACAGCTATGATAAAGCTTGTTCTAATAAAAACTACGTTTGGT
GA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445759	(Get FASTA)	NCBI Sequence Viewer
	XP_008768967	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF99392	(Get FASTA)	NCBI Sequence Viewer
	AAH87009	(Get FASTA)	NCBI Sequence Viewer
	ABL73891	(Get FASTA)	NCBI Sequence Viewer
	ABL73892	(Get FASTA)	NCBI Sequence Viewer
	ABL73893	(Get FASTA)	NCBI Sequence Viewer
	EDL85337	(Get FASTA)	NCBI Sequence Viewer
	Q923M1	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_445759 ⟸ NM_053307

- UniProtKB:

Q923M1 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MLSASRRTLQLLSSSIPVRMMGDSSSKVISAEEALPGRTESIPVAAKHHVSGNRTVEPFPEGTQ
MAVFGMGCFWGAERKFWLLKGVYSTQVGFAGGYTRNPTYKEVCSEKTGHAEVVRVVYRPEHVSF
EELLKVFWENHDPTQGMRQGNDCGTQYRSAVYPTSAVQMEAALKSKEEYQKVLSKHGFGPITTD
IREGQVFYYAEDYHQQYLSKNPDGYCGLGGTGVSCPTAIKK

hide sequence

RefSeq Acc Id:	XP_008768967 ⟸ XM_008770745
- Peptide Label:	isoform X1
- UniProtKB:	Q923M1 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MLSASRRTLQLLSSSIPVRMMGDSSSKVISAEEALPGRTESIPVAAKHHVSGNRTVEPFPEGTQ MAVFGMGCFWGAERKFWLLKGVYSTQVGFAGGYTRNPTYKEVCSEKTGHAEVVRVVYRPEHVSF EELLKVFWENHDPTQGMRQGNDCGTQYRSAVYPTSAVQMEAALKSKEEYQKVLSKHGFGPITTD IREGQVFYYAEDYHQQYLSKNPDGYCGLGGTGVSCPTAIKK hide sequence

RefSeq Acc Id:

ENSRNOP00000067242 ⟸ ENSRNOT00000072997

RefSeq Acc Id:

ENSRNOP00000016616 ⟸ ENSRNOT00000016616

Protein Domains

PMSR

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699784

Promoter ID:

EPDNEW_R10308

Type:

initiation region

Name:

Msra_1

Description:

methionine sulfoxide reductase A

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	47,800,066 - 47,800,126	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70979	AgrOrtholog
Ensembl Genes	ENSRNOG00000012440	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000016616	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOP00000067242	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000016616	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOT00000072997	UniProtKB/TrEMBL
Gene3D-CATH	3.30.1060.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7107102	IMAGE-MGC_LOAD
InterPro	Met_Sox_Rdtase_MsrA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Met_Sox_Rdtase_MsrA_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:29447	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:93315	IMAGE-MGC_LOAD
NCBI Gene	29447	ENTREZGENE
Pfam	PMSR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Msra	PhenoGen
Superfamily-SCOP	SSF55068	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs	msrA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Rn.163306	ENTREZGENE
UniProt	F1LSJ6_RAT	UniProtKB/TrEMBL
	M0RCC8_RAT	UniProtKB/TrEMBL
	MSRA_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	A9LAT3	UniProtKB/Swiss-Prot
	A9LAT4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-07-09	Msra	methionine sulfoxide reductase A			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expression may decrease with age	70794

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD