Gene: Wdr45 (WD repeat domain 45) Rattus norvegicus
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Symbol: Wdr45
Name: WD repeat domain 45
Description: ENCODES a protein that exhibits phosphatidylinositol phosphate binding (ortholog); protein kinase binding (ortholog); INVOLVED IN autophagosome assembly (ortholog); autophagy (ortholog); cellular response to starvation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); CEREBRAL-CEREBELLAR-COLOBOMA SYNDROME, X-LINKED (ortholog); childhood onset epileptic encephalopathy (ortholog); FOUND IN phagophore assembly site (ortholog); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; endosulfan
AGR Description: Predicted to have phosphatidylinositol-3,5-bisphosphate binding activity, phosphatidylinositol-3-phosphate binding activity, and protein kinase binding activity; predicted to be involved in several processes, including autophagy of mitochondrion, cellular response to starvation, and protein lipidation; predicted to localize to the cytosol, extrinsic component of membrane, and phagophore assembly site membrane; orthologous to human WDR45 (WD repeat domain 45).
Merged Description: Predicted to have phosphatidylinositol-3,5-bisphosphate binding activity, phosphatidylinositol-3-phosphate binding activity, and protein kinase binding activity; predicted to be involved in several processes, including autophagy of mitochondrion, cellular response to starvation, and protein lipidation; predicted to localize to the cytosol, extrinsic component of membrane, and phagophore assembly site membrane; orthologous to human WDR45 (WD repeat domain 45); INTERACTS WITH 2,4-dinitrotoluene; bisphenol A; endosulfan.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: LOC302559; similar to DNA segment, Chr X, Immunex 38, expressed; WD repeat domain phosphoinositide-interacting protein 4; WD repeat-containing protein 45; WIPI-4
Orthologs:
Homo sapiens (human) : WDR45 (WD repeat domain 45)  HGNC  Alliance
Mus musculus (house mouse) : Wdr45 (WD repeat domain 45)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wdr45 (WD repeat domain 45)
Pan paniscus (bonobo/pygmy chimpanzee) : WDR45 (WD repeat domain 45)
Canis lupus familiaris (dog) : WDR45 (WD repeat domain 45)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wdr45 (WD repeat domain 45)
Sus scrofa (pig) : WDR45 (WD repeat domain 45)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X15,621,249 - 15,627,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X16,402,686 - 16,408,439 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,816,610 - 26,822,245 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X26,870,079 - 26,875,714 (-)NCBI
CeleraX14,860,493 - 14,866,128 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 5.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
 
More on Wdr45
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1359718
Created: 2005-07-29
Species: Rattus norvegicus
Last Modified: 2019-04-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.