Wdr45 (WD repeat domain 45) - Rat Genome Database

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Gene: Wdr45 (WD repeat domain 45) Rattus norvegicus
Analyze
Symbol: Wdr45
Name: WD repeat domain 45
RGD ID: 1359718
Description: Predicted to enable phosphatidylinositol-3,5-bisphosphate binding activity; phosphatidylinositol-3-phosphate binding activity; and protein kinase binding activity. Predicted to be involved in several processes, including autophagy of mitochondrion; positive regulation of autophagosome assembly; and protein localization to phagophore assembly site. Predicted to be located in phagophore assembly site. Predicted to be active in cytosol and phagophore assembly site membrane. Predicted to be extrinsic component of membrane. Human ortholog(s) of this gene implicated in neurodegeneration with brain iron accumulation 5. Orthologous to human WDR45 (WD repeat domain 45); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC302559; similar to DNA segment, Chr X, Immunex 38, expressed; WD repeat domain phosphoinositide-interacting protein 4; WD repeat-containing protein 45; WIPI-4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X14,776,280 - 14,782,197 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX14,776,293 - 14,782,202 (-)Ensembl
Rnor_6.0X15,621,249 - 15,627,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,621,209 - 15,627,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,402,686 - 16,408,439 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,816,610 - 26,822,245 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X26,870,079 - 26,875,714 (-)NCBI
CeleraX14,860,493 - 14,866,128 (-)NCBICelera
Cytogenetic MapXq12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:15489334   PMID:23435086   PMID:28561066  


Genomics

Comparative Map Data
Wdr45
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X14,776,280 - 14,782,197 (-)NCBImRatBN7.2
mRatBN7.2 EnsemblX14,776,293 - 14,782,202 (-)Ensembl
Rnor_6.0X15,621,249 - 15,627,159 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX15,621,209 - 15,627,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X16,402,686 - 16,408,439 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X26,816,610 - 26,822,245 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X26,870,079 - 26,875,714 (-)NCBI
CeleraX14,860,493 - 14,866,128 (-)NCBICelera
Cytogenetic MapXq12NCBI
WDR45
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X49,074,442 - 49,101,178 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 EnsemblX49,074,433 - 49,101,170 (-)EnsemblGRCh38hg38GRCh38
GRCh37X48,932,101 - 48,958,116 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X48,819,036 - 48,845,003 (-)NCBINCBI36hg18NCBI36
Build 34X48,688,548 - 48,714,308NCBI
CeleraX52,706,432 - 52,732,399 (+)NCBI
Cytogenetic MapXp11.23NCBI
HuRefX46,588,725 - 46,614,834 (-)NCBIHuRef
CHM1_1X48,963,413 - 48,989,776 (-)NCBICHM1_1
Wdr45
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X7,588,193 - 7,594,440 (+)NCBIGRCm39mm39
GRCm39 EnsemblX7,580,572 - 7,594,445 (+)Ensembl
GRCm38X7,721,987 - 7,728,201 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX7,714,333 - 7,728,206 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X7,299,375 - 7,305,327 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X6,879,208 - 6,885,160 (+)NCBImm8
CeleraX3,742,357 - 3,748,359 (-)NCBICelera
Cytogenetic MapXA1.1NCBI
cM MapX3.48NCBI
Wdr45
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955543597,814 - 603,963 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955543597,796 - 604,163 (-)NCBIChiLan1.0ChiLan1.0
WDR45
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X49,228,153 - 49,233,960 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX49,224,864 - 49,233,960 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X41,372,722 - 41,400,441 (-)NCBIMhudiblu_PPA_v0panPan3
WDR45
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X42,221,261 - 42,237,535 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX42,218,046 - 42,226,422 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX16,596,869 - 16,613,180 (-)NCBI
ROS_Cfam_1.0X42,357,475 - 42,373,725 (-)NCBI
ROS_Cfam_1.0 EnsemblX42,357,480 - 42,363,342 (-)Ensembl
UMICH_Zoey_3.1X42,343,804 - 42,360,115 (-)NCBI
UNSW_CanFamBas_1.0X42,331,450 - 42,347,770 (-)NCBI
UU_Cfam_GSD_1.0X42,426,205 - 42,442,519 (-)NCBI
Wdr45
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X34,734,724 - 34,740,594 (-)NCBI
SpeTri2.0NW_004936721975,113 - 981,149 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
WDR45
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX43,147,476 - 43,156,195 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X43,150,691 - 43,155,981 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X47,998,631 - 48,003,934 (-)NCBISscrofa10.2Sscrofa10.2susScr3
WDR45
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X46,183,278 - 46,188,564 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 EnsemblX46,183,443 - 46,188,536 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607611,748,609 - 11,754,464 (-)NCBIVero_WHO_p1.0
Wdr45
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624893845,689 - 852,221 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
MARC_3991-3992:996679250:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X14,778,482 - 14,779,975 (+)MAPPERmRatBN7.2
Rnor_6.0X15,623,440 - 15,624,932NCBIRnor6.0
Rnor_5.0X16,404,889 - 16,406,381UniSTSRnor5.0
RGSC_v3.4X26,818,801 - 26,820,293UniSTSRGSC3.4
CeleraX14,862,684 - 14,864,176UniSTS
Cytogenetic MapXq13UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631204Gluco15Glucose level QTL 150.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)X162371522646544Rat
70165Bp64Blood pressure QTL 645.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)X144812931706553Rat
1298071Edpm12Estrogen-dependent pituitary mass QTL 123.2pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)X292789847927898Rat
631666Iddm5Insulin dependent diabetes mellitus QTL 5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)X449454949494549Rat
731181Uae27Urinary albumin excretion QTL 272.70.0059urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)X143491017Rat
634325Bw13Body weight QTL 130body mass (VT:0001259)body weight (CMO:0000012)X144797220991088Rat
10755455Coatc13Coat color QTL 130coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7440600049406000Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:75
Count of miRNA genes:64
Interacting mature miRNAs:71
Transcripts:ENSRNOT00000013369
Prediction methods:Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 53 37 19 37 8 11 74 35 34 11 8
Low 4 4 4 7
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001013958 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001398795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256710 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256712 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099635 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099636 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099637 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005497960 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC130624 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ225212 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233394 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000013369   ⟹   ENSRNOP00000013369
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,776,295 - 14,782,202 (-)Ensembl
Rnor_6.0 EnsemblX15,621,209 - 15,627,235 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000099569   ⟹   ENSRNOP00000089374
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,776,293 - 14,781,927 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000100366   ⟹   ENSRNOP00000081313
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,776,295 - 14,782,202 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000101997   ⟹   ENSRNOP00000088610
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,776,295 - 14,782,202 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000118193   ⟹   ENSRNOP00000094004
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 EnsemblX14,776,295 - 14,782,202 (-)Ensembl
RefSeq Acc Id: NM_001013958   ⟹   NP_001013980
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,292 - 14,781,927 (-)NCBI
Rnor_6.0X15,621,249 - 15,626,884 (-)NCBI
Rnor_5.0X16,402,686 - 16,408,439 (-)NCBI
RGSC_v3.4X26,816,610 - 26,822,245 (-)RGD
CeleraX14,860,493 - 14,866,128 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256710   ⟹   XP_006256772
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,280 - 14,781,939 (-)NCBI
Rnor_6.0X15,621,249 - 15,626,900 (-)NCBI
Rnor_5.0X16,402,686 - 16,408,439 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256712   ⟹   XP_006256774
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,280 - 14,782,181 (-)NCBI
Rnor_6.0X15,621,249 - 15,627,159 (-)NCBI
Rnor_5.0X16,402,686 - 16,408,439 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256713   ⟹   XP_006256775
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,280 - 14,781,927 (-)NCBI
Rnor_6.0X15,621,249 - 15,626,883 (-)NCBI
Rnor_5.0X16,402,686 - 16,408,439 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256714   ⟹   XP_006256776
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,280 - 14,781,960 (-)NCBI
Rnor_6.0X15,621,249 - 15,626,908 (-)NCBI
Rnor_5.0X16,402,686 - 16,408,439 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773071   ⟹   XP_008771293
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,280 - 14,780,865 (-)NCBI
Rnor_6.0X15,621,249 - 15,625,474 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099632   ⟹   XP_038955560
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,280 - 14,781,935 (-)NCBI
RefSeq Acc Id: XM_039099633   ⟹   XP_038955561
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,280 - 14,780,855 (-)NCBI
RefSeq Acc Id: XM_039099634   ⟹   XP_038955562
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,280 - 14,781,885 (-)NCBI
RefSeq Acc Id: XM_039099635   ⟹   XP_038955563
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,280 - 14,782,197 (-)NCBI
RefSeq Acc Id: XM_039099636   ⟹   XP_038955564
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,280 - 14,782,179 (-)NCBI
RefSeq Acc Id: XM_039099637   ⟹   XP_038955565
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,776,280 - 14,781,939 (-)NCBI
RefSeq Acc Id: XR_005497959
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,777,058 - 14,781,939 (-)NCBI
RefSeq Acc Id: XR_005497960
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X14,777,058 - 14,781,951 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001013980   ⟸   NM_001013958
- UniProtKB: Q5U2Y0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256774   ⟸   XM_006256712
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006256776   ⟸   XM_006256714
- Peptide Label: isoform X2
- UniProtKB: A0A140TAA5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256772   ⟸   XM_006256710
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006256775   ⟸   XM_006256713
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008771293   ⟸   XM_008773071
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000013369   ⟸   ENSRNOT00000013369
RefSeq Acc Id: XP_038955563   ⟸   XM_039099635
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955564   ⟸   XM_039099636
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955565   ⟸   XM_039099637
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038955560   ⟸   XM_039099632
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038955562   ⟸   XM_039099634
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038955561   ⟸   XM_039099633
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000089374   ⟸   ENSRNOT00000099569
RefSeq Acc Id: ENSRNOP00000081313   ⟸   ENSRNOT00000100366
RefSeq Acc Id: ENSRNOP00000088610   ⟸   ENSRNOT00000101997
RefSeq Acc Id: ENSRNOP00000094004   ⟸   ENSRNOT00000118193

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5U2Y0-F1-model_v2 AlphaFold Q5U2Y0 1-309 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701745
Promoter ID:EPDNEW_R12269
Type:single initiation site
Name:Wdr45_1
Description:WD repeat domain 45
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X15,627,152 - 15,627,212EPDNEW

Strain Variation

Strain Sequence Variants (MRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
X 15623230 15623231 C T snv CDS, FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), GH/OmrMcwi (MCW), SBH/Ygl (MCW), SBN/Ygl (MCW), PVG/Seac (2019), FHH/EurMcwi (RGD), FHL/EurMcwi (RGD), SBH/Ygl (RGD), SBN/Ygl (RGD), FHH/EurMcwi (2019), MR/N (2020), MR/N (MCW)


Assembly: Rnor_5.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
X 16404679 16404680 C T snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), GH/OmrMcwi (MCW), SBH/Ygl (MCW), SBN/Ygl (MCW), RCS/Kyo (KyushuU), FHH/EurMcwi (KNAW), FHL/EurMcwi (KNAW), SBH/Ygl (KNAW), SBN/Ygl (KNAW), MR/N (KNAW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
X 26818591 26818592 C T snv FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), FHH/EurMcwi (MDC), MR/N (KNAW), GH/OmrMcwi (MCW), HCR/2Mco (UMich), FHL/EurMcwi (ICL), SBH/Ygl (ICL), SBN/Ygl (ICL), HCR/1Mco (UMich), LCR/1Mco (UMich), FHH/EurMcwi (ICL)


Assembly: mRatBN7.2

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
X 14778273 14778274 C T snv FHH/EurMcwi (2019), PVG/Seac (2019), MR/N (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1359718 AgrOrtholog
BioCyc Gene G2FUF-2914 BioCyc
Ensembl Genes ENSRNOG00000009749 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000013369 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000089374 ENTREZGENE
  ENSRNOP00000094004 ENTREZGENE
Ensembl Transcript ENSRNOT00000013369 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000099569 ENTREZGENE
  ENSRNOT00000118193 ENTREZGENE
Gene3D-CATH 2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7123612 IMAGE-MGC_LOAD
InterPro WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  WIPI4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:302559 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94061 IMAGE-MGC_LOAD
NCBI Gene 302559 ENTREZGENE
PANTHER PTHR11227:SF44 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam WD40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Wdr45 PhenoGen
SMART WD40 UniProtKB/TrEMBL
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A140TAA5 ENTREZGENE, UniProtKB/TrEMBL
  Q5U2Y0 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-03-30 Wdr45  WD repeat domain 45  LOC302559  similar to DNA segment, Chr X, Immunex 38, expressed  Symbol and Name updated 1299863 APPROVED
2005-07-29 LOC302559  similar to DNA segment, Chr X, Immunex 38, expressed      Symbol and Name status set to provisional 70820 PROVISIONAL