Il23a (interleukin 23 subunit alpha) - Rat Genome Database
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Gene: Il23a (interleukin 23 subunit alpha) Rattus norvegicus
Analyze
Symbol: Il23a
Name: interleukin 23 subunit alpha
RGD ID: 620873
Description: Predicted to contribute to interleukin-23 receptor binding activity. Predicted to be involved in several processes, including positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; positive regulation of lymphocyte activation; and positive regulation of macromolecule metabolic process. Predicted to localize to interleukin-23 complex. Orthologous to human IL23A (interleukin 23 subunit alpha); PARTICIPATES IN interleukin-23 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-chloro-2,4-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IL-23 subunit alpha; IL-23-A; IL-23p19; Interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; interleukin-23 subunit p19; MGC114275
Orthologs:
Homo sapiens (human) : IL23A (interleukin 23 subunit alpha)  HGNC  Alliance
Mus musculus (house mouse) : Il23a (interleukin 23, alpha subunit p19)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il23a (interleukin 23 subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : IL23A (interleukin 23 subunit alpha)
Canis lupus familiaris (dog) : IL23A (interleukin 23 subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il23a (interleukin 23 subunit alpha)
Sus scrofa (pig) : IL23A (interleukin 23 subunit alpha)
Chlorocebus sabaeus (African green monkey) : IL23A (interleukin 23 subunit alpha)
Heterocephalus glaber (naked mole-rat) : Il23a (interleukin 23 subunit alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.072,710,609 - 2,712,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,710,609 - 2,712,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,689,128 - 2,691,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,584,112 - 1,586,226 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.171,584,111 - 1,586,226 (-)NCBI
Celera7597,260 - 599,374 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
6alpha-methylprednisolone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-D-glucan  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bucladesine  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
cisplatin  (ISO)
Colforsin dapropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cyanidin cation  (EXP,ISO)
cyclophosphamide  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
estriol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ferulic acid  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fragrance  (ISO)
furan  (EXP)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxychloroquine  (ISO)
imiquimod  (ISO)
levamisole  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
melphalan  (ISO)
methotrexate  (ISO)
misoprostol  (ISO)
muramyl dipeptide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
ozone  (ISO)
paracetamol  (ISO)
peptidoglycan  (ISO)
phenytoin  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phytoestrogen  (ISO)
pioglitazone  (ISO)
piroxicam  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (ISO)
rac-lactic acid  (ISO)
resiquimod  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium sulfate  (ISO)
tacrolimus hydrate  (ISO)
tetrachloromethane  (EXP,ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
vincristine  (ISO)
wortmannin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
defense response to Gram-negative bacterium  (ISO)
defense response to virus  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
negative regulation of interleukin-10 production  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of activation of Janus kinase activity  (IBA,ISO)
positive regulation of defense response to virus by host  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of interferon-gamma production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of memory T cell differentiation  (ISO)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of NK T cell activation  (ISO)
positive regulation of NK T cell proliferation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
positive regulation of T cell proliferation  (IBA,ISO)
positive regulation of T-helper 1 type immune response  (ISO)
positive regulation of T-helper 17 cell lineage commitment  (IBA,ISO)
positive regulation of T-helper 17 type immune response  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
regulation of tyrosine phosphorylation of STAT protein  (ISO)
signal transduction  (IEA)
T cell proliferation  (ISO)
tissue remodeling  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Aggarwal S, etal., J Biol Chem 2003 Jan 17;278(3):1910-4.
2. Bereswill S, etal., PLoS One. 2016 Jun 20;11(6):e0158020. doi: 10.1371/journal.pone.0158020. eCollection 2016.
3. Broberg EK, etal., J Interferon Cytokine Res. 2002 Jun;22(6):641-51. doi: 10.1089/10799900260100123.
4. Chackerian AA, etal., Infect Immun. 2006 Nov;74(11):6092-9. doi: 10.1128/IAI.00621-06. Epub 2006 Aug 21.
5. Conti HR, etal., J Exp Med. 2009 Feb 16;206(2):299-311. doi: 10.1084/jem.20081463. Epub 2009 Feb 9.
6. Cooper AM, etal., J Immunol. 2002 Feb 1;168(3):1322-7. doi: 10.4049/jimmunol.168.3.1322.
7. Cruz A, etal., J Exp Med. 2010 Aug 2;207(8):1609-16. doi: 10.1084/jem.20100265. Epub 2010 Jul 12.
8. Dietze-Schwonberg K, etal., Exp Dermatol. 2018 Jan;27(1):101-103. doi: 10.1111/exd.13455. Epub 2017 Dec 6.
9. Ding H, etal., PLoS One. 2013 Jul 11;8(7):e69384. doi: 10.1371/journal.pone.0069384. Print 2013.
10. Erdmann H, etal., Immunobiology. 2013 Jun;218(6):910-23. doi: 10.1016/j.imbio.2012.10.005. Epub 2012 Oct 26.
11. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Happel KI, etal., Alcohol Clin Exp Res. 2006 Jul;30(7):1200-7. doi: 10.1111/j.1530-0277.2006.00144.x.
13. Happel KI, etal., J Exp Med. 2005 Sep 19;202(6):761-9. doi: 10.1084/jem.20050193. Epub 2005 Sep 12.
14. Heimesaat MM, etal., Gut Pathog. 2016 Jul 6;8:21. doi: 10.1186/s13099-016-0106-4. eCollection 2016.
15. Indramohan M, etal., Infect Immun. 2012 Dec;80(12):4099-105. doi: 10.1128/IAI.00589-12. Epub 2012 Sep 10.
16. Khader SA, etal., J Immunol. 2005 Jul 15;175(2):788-95. doi: 10.4049/jimmunol.175.2.788.
17. Kitada S, etal., J Exp Med. 2017 May 1;214(5):1313-1331. doi: 10.1084/jem.20161076. Epub 2017 Mar 29.
18. Kleinschek MA, etal., J Immunol. 2006 Jan 15;176(2):1098-106. doi: 10.4049/jimmunol.176.2.1098.
19. Kurtz SL, etal., PLoS One. 2014 Oct 8;9(10):e109898. doi: 10.1371/journal.pone.0109898. eCollection 2014.
20. Lieberman LA, etal., J Immunol. 2004 Aug 1;173(3):1887-93. doi: 10.4049/jimmunol.173.3.1887.
21. McDermott AJ, etal., Immunology. 2016 Jan;147(1):114-24. doi: 10.1111/imm.12545. Epub 2015 Dec 2.
22. Meeks KD, etal., J Immunol. 2009 Dec 15;183(12):8026-34. doi: 10.4049/jimmunol.0901588.
23. MGD data from the GO Consortium
24. NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Noll J, etal., J Hepatol. 2016 May;64(5):1147-1157. doi: 10.1016/j.jhep.2016.01.013. Epub 2016 Jan 22.
26. Ogawa R, etal., Allergol Int. 2015 Sep;64 Suppl:S24-9. doi: 10.1016/j.alit.2015.04.005. Epub 2015 May 16.
27. Okada Y, etal., Clin Exp Immunol. 2013 Dec;174(3):459-71. doi: 10.1111/cei.12200.
28. Peltoniemi J, etal., Clin Exp Immunol. 2004 Aug;137(2):305-12. doi: 10.1111/j.1365-2249.2004.02528.x.
29. Peng J, etal., Cell Res. 2010 Jan;20(1):62-71. Epub 2009 Nov 24.
30. Pipeline to import KEGG annotations from KEGG into RGD
31. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. RGD automated data pipeline
33. RGD automated import pipeline for gene-chemical interactions
34. Rudner XL, etal., Infect Immun. 2007 Jun;75(6):3055-61. doi: 10.1128/IAI.01329-06. Epub 2007 Apr 2.
35. Szymczak WA, etal., Am J Pathol. 2012 Apr;180(4):1547-59. doi: 10.1016/j.ajpath.2011.12.038. Epub 2012 Feb 16.
36. Teixeira-Coelho M, etal., Int Immunol. 2011 Feb;23(2):89-96. doi: 10.1093/intimm/dxq459. Epub 2010 Dec 14.
Additional References at PubMed
PMID:11114383   PMID:12023369   PMID:12421946   PMID:12477932   PMID:14688363   PMID:15114670   PMID:15265908   PMID:15489334   PMID:15990448   PMID:16482511   PMID:16751425   PMID:16982811  
PMID:17888176   PMID:19088061   PMID:19289819   PMID:19501566   PMID:19666510   PMID:19714651   PMID:20027291   PMID:21148126   PMID:25600958   PMID:26174742   PMID:27185171   PMID:29039526  


Genomics

Comparative Map Data
Il23a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.072,710,609 - 2,712,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,710,609 - 2,712,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,689,128 - 2,691,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,584,112 - 1,586,226 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.171,584,111 - 1,586,226 (-)NCBI
Celera7597,260 - 599,374 (-)NCBICelera
Cytogenetic Map7q11NCBI
IL23A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1256,334,174 - 56,340,410 (+)EnsemblGRCh38hg38GRCh38
GRCh381256,334,159 - 56,340,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371256,732,663 - 56,734,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,018,930 - 55,020,461 (+)NCBINCBI36hg18NCBI36
Build 341255,018,929 - 55,020,460NCBI
Celera1256,386,015 - 56,387,546 (+)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1253,771,325 - 53,772,856 (+)NCBIHuRef
CHM1_11256,700,047 - 56,701,578 (+)NCBICHM1_1
Il23a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,132,009 - 128,133,953 (-)NCBI
GRCm3810128,296,140 - 128,298,084 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,296,139 - 128,298,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,733,196 - 127,735,140 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610127,699,089 - 127,701,033 (-)NCBImm8
Celera10130,684,464 - 130,686,407 (-)NCBICelera
Cytogenetic Map10D3NCBI
Il23a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,947,803 - 3,949,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,946,964 - 3,949,180 (+)NCBIChiLan1.0ChiLan1.0
IL23A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11232,828,902 - 32,830,621 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,828,902 - 32,830,617 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01232,575,321 - 32,576,856 (-)NCBI
IL23A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl10638,719 - 640,359 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.110635,384 - 640,715 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Il23a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936646743,630 - 745,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL23A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,732,165 - 21,734,267 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,732,416 - 21,733,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IL23A
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1152,295,106 - 52,297,244 (+)Ensembl
ChlSab1.11152,289,486 - 52,296,735 (+)NCBI
Il23a
(Heterocephalus glaber - naked mole-rat)
No map positions available.


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7134147172Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7134828535Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7134828535Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7137009673Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7138119654Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7265313832258115Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:70
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000004363
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 34 19 6 19 6 2 3 74 29 39 11 2
Below cutoff 1 9 36 33 33 6 8 6 2 6

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004363   ⟹   ENSRNOP00000004363
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl72,710,609 - 2,712,723 (-)Ensembl
RefSeq Acc Id: NM_130410   ⟹   NP_569094
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.072,710,609 - 2,712,723 (-)NCBI
Rnor_5.072,689,128 - 2,691,242 (-)NCBI
RGSC_v3.471,584,112 - 1,586,226 (-)RGD
Celera7597,260 - 599,374 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_569094 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98907 (Get FASTA)   NCBI Sequence Viewer  
  AAL18229 (Get FASTA)   NCBI Sequence Viewer  
  EDL84876 (Get FASTA)   NCBI Sequence Viewer  
  Q91Z84 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_569094   ⟸   NM_130410
- Peptide Label: precursor
- UniProtKB: Q91Z84 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004363   ⟸   ENSRNOT00000004363

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620873 AgrOrtholog
Ensembl Genes ENSRNOG00000003254 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000004363 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004363 ENTREZGENE, UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7454618 IMAGE-MGC_LOAD
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-23_alpha UniProtKB/Swiss-Prot
KEGG Report rno:155140 UniProtKB/Swiss-Prot
MGC_CLONE MGC:114275 IMAGE-MGC_LOAD
NCBI Gene 155140 ENTREZGENE
PANTHER PTHR15947 UniProtKB/Swiss-Prot
Pfam IL23 UniProtKB/Swiss-Prot
PhenoGen Il23a PhenoGen
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniGene Rn.81073 ENTREZGENE
UniProt IL23A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Il23a  interleukin 23 subunit alpha  Il23a  Interleukin 23, alpha subunit p19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Il23a  Interleukin 23, alpha subunit p19      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Il23a  Interleukin 23, alpha subunit p19      Symbol and Name status set to provisional 70820 PROVISIONAL

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.