Il23a (interleukin 23 subunit alpha) - Rat Genome Database

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Gene: Il23a (interleukin 23 subunit alpha) Rattus norvegicus
Analyze
Symbol: Il23a
Name: interleukin 23 subunit alpha
RGD ID: 620873
Description: Predicted to enable cytokine activity. Predicted to contribute to interleukin-23 receptor binding activity. Predicted to be involved in several processes, including positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; positive regulation of lymphocyte activation; and regulation of cytokine production. Predicted to act upstream of or within T cell proliferation and positive regulation of transcription by RNA polymerase II. Predicted to be located in extracellular space. Predicted to be part of interleukin-23 complex. Orthologous to human IL23A (interleukin 23 subunit alpha); PARTICIPATES IN interleukin-23 signaling pathway; cytokine mediated signaling pathway; Jak-Stat signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-chloro-2,4-dinitrobenzene; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IL-23 subunit alpha; IL-23-A; IL-23p19; Interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; interleukin-23 subunit p19; MGC114275
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,306,320 - 1,308,434 (-)NCBIGRCr8
mRatBN7.27721,809 - 723,923 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7721,809 - 723,923 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,478,053 - 3,480,168 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,354,036 - 5,356,151 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,656,694 - 5,658,809 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,710,609 - 2,712,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,710,609 - 2,712,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,689,128 - 2,691,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,584,112 - 1,586,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,584,111 - 1,586,226 (-)NCBI
Celera7597,260 - 599,374 (-)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (ISO)
2-tert-butylhydroquinone  (ISO)
4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-methoxypsoralen  (ISO)
6alpha-methylprednisolone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
apilimod  (ISO)
aripiprazole  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
berberine  (ISO)
beta-D-glucan  (ISO)
beta-naphthoflavone  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
bucladesine  (ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
celastrol  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
cyanidin cation  (EXP,ISO)
cyclophosphamide  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dimethyl sulfoxide  (ISO)
disodium selenite  (ISO)
doxorubicin  (EXP,ISO)
endosulfan  (EXP)
estriol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
ferulic acid  (ISO)
flutamide  (EXP)
folic acid  (ISO)
fragrance  (ISO)
furan  (EXP)
gentamycin  (EXP)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
hydroxychloroquine  (ISO)
imiquimod  (ISO)
levamisole  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
malathion  (ISO)
manganese(II) chloride  (EXP)
medroxyprogesterone acetate  (ISO)
melatonin  (ISO)
melphalan  (ISO)
methotrexate  (ISO)
microcystin-LR  (ISO)
misoprostol  (ISO)
muramyl dipeptide  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nimesulide  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
PCB138  (ISO)
peptidoglycan  (ISO)
phenytoin  (ISO)
phorbol 12,13-dibutanoate  (ISO)
phytoestrogen  (ISO)
pioglitazone  (ISO)
piroxicam  (ISO)
poly(methyl methacrylate) macromolecule  (ISO)
potassium dichromate  (ISO)
prednisolone  (ISO)
prostaglandin E1  (ISO)
prostaglandin E2  (ISO)
rac-lactic acid  (ISO)
resiquimod  (ISO)
resveratrol  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sodium sulfate  (ISO)
streptozocin  (ISO)
tacrolimus hydrate  (ISO)
tadalafil  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tofacitinib  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
vincristine  (ISO)
wortmannin  (ISO)
zinc protoporphyrin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface receptor signaling pathway via JAK-STAT  (ISO)
defense response to Gram-negative bacterium  (ISO)
defense response to virus  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
negative regulation of interleukin-10 production  (ISO)
positive regulation of activated T cell proliferation  (ISO)
positive regulation of defense response to virus by host  (ISO)
positive regulation of granulocyte macrophage colony-stimulating factor production  (ISO)
positive regulation of interleukin-10 production  (ISO)
positive regulation of interleukin-12 production  (ISO)
positive regulation of interleukin-17 production  (ISO)
positive regulation of memory T cell differentiation  (ISO)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of NK T cell activation  (ISO)
positive regulation of NK T cell proliferation  (ISO)
positive regulation of osteoclast differentiation  (ISO)
positive regulation of T cell mediated cytotoxicity  (ISO)
positive regulation of T cell proliferation  (IBA,ISO)
positive regulation of T-helper 1 type immune response  (ISO)
positive regulation of T-helper 17 cell lineage commitment  (IBA,ISO)
positive regulation of T-helper 17 type immune response  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type II interferon production  (ISO)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
signal transduction  (IEA)
T cell proliferation  (ISO)
tissue remodeling  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin-17. Aggarwal S, etal., J Biol Chem 2003 Jan 17;278(3):1910-4.
2. Interleukin-18 Mediates Immune Responses to Campylobacter jejuni Infection in Gnotobiotic Mice. Bereswill S, etal., PLoS One. 2016 Jun 20;11(6):e0158020. doi: 10.1371/journal.pone.0158020. eCollection 2016.
3. Herpes simplex virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice. Broberg EK, etal., J Interferon Cytokine Res. 2002 Jun;22(6):641-51. doi: 10.1089/10799900260100123.
4. Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection. Chackerian AA, etal., Infect Immun. 2006 Nov;74(11):6092-9. doi: 10.1128/IAI.00621-06. Epub 2006 Aug 21.
5. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis. Conti HR, etal., J Exp Med. 2009 Feb 16;206(2):299-311. doi: 10.1084/jem.20081463. Epub 2009 Feb 9.
6. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. Cooper AM, etal., J Immunol. 2002 Feb 1;168(3):1322-7. doi: 10.4049/jimmunol.168.3.1322.
7. Pathological role of interleukin 17 in mice subjected to repeated BCG vaccination after infection with Mycobacterium tuberculosis. Cruz A, etal., J Exp Med. 2010 Aug 2;207(8):1609-16. doi: 10.1084/jem.20100265. Epub 2010 Jul 12.
8. Insufficient generation of Th17 cells in IL-23p19-deficient BALB/c mice protects against progressive cutaneous leishmaniasis. Dietze-Schwonberg K, etal., Exp Dermatol. 2018 Jan;27(1):101-103. doi: 10.1111/exd.13455. Epub 2017 Dec 6.
9. Th1-mediated immunity against Helicobacter pylori can compensate for lack of Th17 cells and can protect mice in the absence of immunization. Ding H, etal., PLoS One. 2013 Jul 11;8(7):e69384. doi: 10.1371/journal.pone.0069384. Print 2013.
10. IL-17A promotes macrophage effector mechanisms against Trypanosoma cruzi by trapping parasites in the endolysosomal compartment. Erdmann H, etal., Immunobiology. 2013 Jun;218(6):910-23. doi: 10.1016/j.imbio.2012.10.005. Epub 2012 Oct 26.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Acute alcohol intoxication suppresses the interleukin 23 response to Klebsiella pneumoniae infection. Happel KI, etal., Alcohol Clin Exp Res. 2006 Jul;30(7):1200-7. doi: 10.1111/j.1530-0277.2006.00144.x.
13. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. Happel KI, etal., J Exp Med. 2005 Sep 19;202(6):761-9. doi: 10.1084/jem.20050193. Epub 2005 Sep 12.
14. The IL-23/IL-22/IL-18 axis in murine Campylobacter jejuni infection. Heimesaat MM, etal., Gut Pathog. 2016 Jul 6;8:21. doi: 10.1186/s13099-016-0106-4. eCollection 2016.
15. Inflammatory monocyte recruitment is regulated by interleukin-23 during systemic bacterial infection. Indramohan M, etal., Infect Immun. 2012 Dec;80(12):4099-105. doi: 10.1128/IAI.00589-12. Epub 2012 Sep 10.
16. IL-23 compensates for the absence of IL-12p70 and is essential for the IL-17 response during tuberculosis but is dispensable for protection and antigen-specific IFN-gamma responses if IL-12p70 is available. Khader SA, etal., J Immunol. 2005 Jul 15;175(2):788-95. doi: 10.4049/jimmunol.175.2.788.
17. BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. Kitada S, etal., J Exp Med. 2017 May 1;214(5):1313-1331. doi: 10.1084/jem.20161076. Epub 2017 Mar 29.
18. IL-23 enhances the inflammatory cell response in Cryptococcus neoformans infection and induces a cytokine pattern distinct from IL-12. Kleinschek MA, etal., J Immunol. 2006 Jan 15;176(2):1098-106. doi: 10.4049/jimmunol.176.2.1098.
19. IL-23 p19 knockout mice exhibit minimal defects in responses to primary and secondary infection with Francisella tularensis LVS. Kurtz SL, etal., PLoS One. 2014 Oct 8;9(10):e109898. doi: 10.1371/journal.pone.0109898. eCollection 2014.
20. IL-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. Lieberman LA, etal., J Immunol. 2004 Aug 1;173(3):1887-93. doi: 10.4049/jimmunol.173.3.1887.
21. Interleukin-23 (IL-23), independent of IL-17 and IL-22, drives neutrophil recruitment and innate inflammation during Clostridium difficile colitis in mice. McDermott AJ, etal., Immunology. 2016 Jan;147(1):114-24. doi: 10.1111/imm.12545. Epub 2015 Dec 2.
22. IL-23 is required for protection against systemic infection with Listeria monocytogenes. Meeks KD, etal., J Immunol. 2009 Dec 15;183(12):8026-34. doi: 10.4049/jimmunol.0901588.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. IL-23 prevents IL-13-dependent tissue repair associated with Ly6C(lo) monocytes in Entamoeba histolytica-induced liver damage. Noll J, etal., J Hepatol. 2016 May;64(5):1147-1157. doi: 10.1016/j.jhep.2016.01.013. Epub 2016 Jan 22.
26. Distinct effects of endogenous interleukin-23 on eosinophilic airway inflammation in response to different antigens. Ogawa R, etal., Allergol Int. 2015 Sep;64 Suppl:S24-9. doi: 10.1016/j.alit.2015.04.005. Epub 2015 May 16.
27. Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. Okada Y, etal., Clin Exp Immunol. 2013 Dec;174(3):459-71. doi: 10.1111/cei.12200.
28. Immunomodulation by roquinimex decreases the expression of IL-23 (p19) mRNA in the brains of herpes simplex virus type 1 infected BALB/c mice. Peltoniemi J, etal., Clin Exp Immunol. 2004 Aug;137(2):305-12. doi: 10.1111/j.1365-2249.2004.02528.x.
29. IL-23 signaling enhances Th2 polarization and regulates allergic airway inflammation. Peng J, etal., Cell Res. 2010 Jan;20(1):62-71. Epub 2009 Nov 24.
30. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
31. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
32. Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease. Qiu Y, etal., Sci Rep. 2017 Apr 21;7(1):1007. doi: 10.1038/s41598-017-01249-7.
33. GOA pipeline RGD automated data pipeline
34. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
35. Interleukin-23 (IL-23)-IL-17 cytokine axis in murine Pneumocystis carinii infection. Rudner XL, etal., Infect Immun. 2007 Jun;75(6):3055-61. doi: 10.1128/IAI.01329-06. Epub 2007 Apr 2.
36. IL-23 dampens the allergic response to Cryptococcus neoformans through IL-17-independent and -dependent mechanisms. Szymczak WA, etal., Am J Pathol. 2012 Apr;180(4):1547-59. doi: 10.1016/j.ajpath.2011.12.038. Epub 2012 Feb 16.
37. TLR2 deficiency by compromising p19 (IL-23) expression limits Th 17 cell responses to Mycobacterium tuberculosis. Teixeira-Coelho M, etal., Int Immunol. 2011 Feb;23(2):89-96. doi: 10.1093/intimm/dxq459. Epub 2010 Dec 14.
Additional References at PubMed
PMID:11114383   PMID:12023369   PMID:12421946   PMID:12477932   PMID:14688363   PMID:15114670   PMID:15265908   PMID:15489334   PMID:15990448   PMID:16482511   PMID:16751425   PMID:16982811  
PMID:17888176   PMID:19088061   PMID:19289819   PMID:19501566   PMID:19666510   PMID:19714651   PMID:20027291   PMID:21148126   PMID:25600958   PMID:26174742   PMID:27185171   PMID:29039526  
PMID:34491653  


Genomics

Comparative Map Data
Il23a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,306,320 - 1,308,434 (-)NCBIGRCr8
mRatBN7.27721,809 - 723,923 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7721,809 - 723,923 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,478,053 - 3,480,168 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,354,036 - 5,356,151 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,656,694 - 5,658,809 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,710,609 - 2,712,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,710,609 - 2,712,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,689,128 - 2,691,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,584,112 - 1,586,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,584,111 - 1,586,226 (-)NCBI
Celera7597,260 - 599,374 (-)NCBICelera
Cytogenetic Map7q11NCBI
IL23A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,338,884 - 56,340,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,334,174 - 56,340,410 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,732,668 - 56,734,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,018,930 - 55,020,461 (+)NCBINCBI36Build 36hg18NCBI36
Build 341255,018,929 - 55,020,460NCBI
Celera1256,386,015 - 56,387,546 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,771,325 - 53,772,856 (+)NCBIHuRef
CHM1_11256,700,047 - 56,701,578 (+)NCBICHM1_1
T2T-CHM13v2.01256,306,530 - 56,308,056 (+)NCBIT2T-CHM13v2.0
Il23a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,132,009 - 128,133,953 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,132,008 - 128,134,621 (-)EnsemblGRCm39 Ensembl
GRCm3810128,296,140 - 128,298,084 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,296,139 - 128,298,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,733,196 - 127,735,140 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,699,089 - 127,701,033 (-)NCBIMGSCv36mm8
Celera10130,684,464 - 130,686,407 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.51NCBI
Il23a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,947,803 - 3,949,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,946,964 - 3,949,180 (+)NCBIChiLan1.0ChiLan1.0
IL23A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,992,032 - 37,993,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,987,711 - 37,990,161 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,575,321 - 32,576,856 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,828,902 - 32,830,621 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,828,902 - 32,830,617 (-)Ensemblpanpan1.1panPan2
IL23A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110635,384 - 640,715 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10638,719 - 640,359 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10700,688 - 704,049 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010646,091 - 649,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10647,540 - 649,181 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110623,343 - 626,704 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010866,496 - 869,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010990,220 - 993,580 (+)NCBIUU_Cfam_GSD_1.0
Il23a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,124,372 - 58,126,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646743,688 - 745,836 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646743,630 - 745,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL23A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,732,165 - 21,734,267 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,732,416 - 21,733,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IL23A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,289,486 - 52,296,735 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,295,106 - 52,297,244 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,689,882 - 193,696,291 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il23a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,662,753 - 11,665,418 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,662,851 - 11,664,444 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Il23a
6 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:86
Count of miRNA genes:70
Interacting mature miRNAs:81
Transcripts:ENSRNOT00000004363
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 2 34 19 6 19 6 2 3 74 29 39 11 2
Below cutoff 1 9 36 33 33 6 8 6 2 6

Sequence


RefSeq Acc Id: ENSRNOT00000004363   ⟹   ENSRNOP00000004363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl7721,809 - 723,923 (-)Ensembl
Rnor_6.0 Ensembl72,710,609 - 2,712,723 (-)Ensembl
RefSeq Acc Id: NM_130410   ⟹   NP_569094
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,306,320 - 1,308,434 (-)NCBI
mRatBN7.27721,809 - 723,923 (-)NCBI
Rnor_6.072,710,609 - 2,712,723 (-)NCBI
Rnor_5.072,689,128 - 2,691,242 (-)NCBI
RGSC_v3.471,584,112 - 1,586,226 (-)RGD
Celera7597,260 - 599,374 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_569094 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH98907 (Get FASTA)   NCBI Sequence Viewer  
  AAL18229 (Get FASTA)   NCBI Sequence Viewer  
  EDL84876 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000004363.2
  ENSRNOP00055019065
  ENSRNOP00060035039
  ENSRNOP00065017159
GenBank Protein Q91Z84 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_569094   ⟸   NM_130410
- Peptide Label: precursor
- UniProtKB: Q91Z84 (UniProtKB/Swiss-Prot),   A6KSB6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000004363   ⟸   ENSRNOT00000004363

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q91Z84-F1-model_v2 AlphaFold Q91Z84 1-196 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620873 AgrOrtholog
BioCyc Gene G2FUF-35379 BioCyc
Ensembl Genes ENSRNOG00000003254 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055013661 UniProtKB/Swiss-Prot
  ENSRNOG00060024397 UniProtKB/Swiss-Prot
  ENSRNOG00065013455 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000004363.4 UniProtKB/Swiss-Prot
  ENSRNOT00055023453 UniProtKB/Swiss-Prot
  ENSRNOT00060042256 UniProtKB/Swiss-Prot
  ENSRNOT00065022129 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7454618 IMAGE-MGC_LOAD
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-23_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:155140 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:114275 IMAGE-MGC_LOAD
NCBI Gene 155140 ENTREZGENE
PANTHER INTERLEUKIN-23 SUBUNIT ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15947 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam IL23 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il23a PhenoGen
RatGTEx ENSRNOG00000003254 RatGTEx
  ENSRNOG00055013661 RatGTEx
  ENSRNOG00060024397 RatGTEx
  ENSRNOG00065013455 RatGTEx
Superfamily-SCOP 4-helical cytokines UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
UniProt A6KSB6 ENTREZGENE, UniProtKB/TrEMBL
  IL23A_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-16 Il23a  interleukin 23 subunit alpha  Il23a  Interleukin 23, alpha subunit p19  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Il23a  Interleukin 23, alpha subunit p19      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Il23a  Interleukin 23, alpha subunit p19      Symbol and Name status set to provisional 70820 PROVISIONAL