IL23A (interleukin 23 subunit alpha) - Rat Genome Database

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Gene: IL23A (interleukin 23 subunit alpha) Canis lupus familiaris
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Symbol: IL23A
Name: interleukin 23 subunit alpha
RGD ID: 12246608
Description: ENCODES a protein that exhibits interleukin-23 receptor binding (ortholog); INVOLVED IN positive regulation of transcription by RNA polymerase II (ortholog); T cell proliferation (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN extracellular region (inferred); extracellular space (inferred); interleukin-23 complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: interleukin-23 subunit alpha
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110635,384 - 640,715 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10638,719 - 640,359 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10700,688 - 704,049 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010646,091 - 649,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10647,540 - 649,181 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110623,343 - 626,704 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010866,496 - 869,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010990,220 - 993,580 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell surface receptor signaling pathway via JAK-STAT  (IEA)
cell surface receptor signaling pathway via STAT  (IEA)
defense response to Gram-negative bacterium  (IEA)
defense response to virus  (IEA)
immune response  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
negative regulation of interleukin-10 production  (IEA)
positive regulation of activated T cell proliferation  (IEA)
positive regulation of defense response to virus by host  (IEA)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IEA)
positive regulation of interleukin-10 production  (IEA)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-17 production  (IEA)
positive regulation of memory T cell differentiation  (IEA)
positive regulation of natural killer cell proliferation  (IEA)
positive regulation of neutrophil chemotaxis  (IEA)
positive regulation of NK T cell activation  (IEA)
positive regulation of NK T cell proliferation  (IEA)
positive regulation of osteoclast differentiation  (IEA)
positive regulation of T cell mediated cytotoxicity  (IEA)
positive regulation of T cell proliferation  (IEA)
positive regulation of T-helper 1 type immune response  (IEA)
positive regulation of T-helper 17 cell lineage commitment  (IEA)
positive regulation of T-helper 17 type immune response  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type II interferon production  (IEA)
T cell proliferation  (IEA,ISO)
tissue remodeling  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
IL23A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110635,384 - 640,715 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10638,719 - 640,359 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10700,688 - 704,049 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.010646,091 - 649,452 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl10647,540 - 649,181 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.110623,343 - 626,704 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010866,496 - 869,858 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010990,220 - 993,580 (+)NCBIUU_Cfam_GSD_1.0
IL23A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381256,338,884 - 56,340,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1256,334,174 - 56,340,410 (+)EnsemblGRCh38hg38GRCh38
GRCh371256,732,668 - 56,734,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,018,930 - 55,020,461 (+)NCBINCBI36Build 36hg18NCBI36
Build 341255,018,929 - 55,020,460NCBI
Celera1256,386,015 - 56,387,546 (+)NCBICelera
Cytogenetic Map12q13.3NCBI
HuRef1253,771,325 - 53,772,856 (+)NCBIHuRef
CHM1_11256,700,047 - 56,701,578 (+)NCBICHM1_1
T2T-CHM13v2.01256,306,530 - 56,308,056 (+)NCBIT2T-CHM13v2.0
Il23a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,132,009 - 128,133,953 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,132,008 - 128,134,621 (-)EnsemblGRCm39 Ensembl
GRCm3810128,296,140 - 128,298,084 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,296,139 - 128,298,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,733,196 - 127,735,140 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610127,699,089 - 127,701,033 (-)NCBIMGSCv36mm8
Celera10130,684,464 - 130,686,407 (-)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1076.51NCBI
Il23a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,306,320 - 1,308,434 (-)NCBIGRCr8
mRatBN7.27721,809 - 723,923 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7721,809 - 723,923 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx73,478,053 - 3,480,168 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.075,354,036 - 5,356,151 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.075,656,694 - 5,658,809 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.072,710,609 - 2,712,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,710,609 - 2,712,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,689,128 - 2,691,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,584,112 - 1,586,226 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.171,584,111 - 1,586,226 (-)NCBI
Celera7597,260 - 599,374 (-)NCBICelera
Cytogenetic Map7q11NCBI
Il23a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,947,803 - 3,949,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,946,964 - 3,949,180 (+)NCBIChiLan1.0ChiLan1.0
IL23A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21037,992,032 - 37,993,395 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11237,987,711 - 37,990,161 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01232,575,321 - 32,576,856 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11232,828,902 - 32,830,621 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,828,902 - 32,830,617 (-)Ensemblpanpan1.1panPan2
Il23a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,124,372 - 58,126,957 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646743,688 - 745,836 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646743,630 - 745,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL23A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,732,165 - 21,734,267 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,732,416 - 21,733,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IL23A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,289,486 - 52,296,735 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1152,295,106 - 52,297,244 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037193,689,882 - 193,696,291 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Il23a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480211,662,753 - 11,665,418 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480211,662,851 - 11,664,444 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in IL23A
35 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 4 5 23 20 14 4 6 4 6 29 21 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000000198   ⟹   ENSCAFP00000000177
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl10638,719 - 640,359 (+)Ensembl
Ensembl Acc Id: ENSCAFT00845014161   ⟹   ENSCAFP00845010977
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl10647,540 - 649,181 (+)Ensembl
RefSeq Acc Id: XM_038487798   ⟹   XP_038343726
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.110623,343 - 626,704 (+)NCBI
RefSeq Acc Id: XM_038549687   ⟹   XP_038405615
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.010990,220 - 993,580 (+)NCBI
RefSeq Acc Id: XM_038613652   ⟹   XP_038469580
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.010866,496 - 869,858 (+)NCBI
RefSeq Acc Id: XM_038679017   ⟹   XP_038534945
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.010646,091 - 649,452 (+)NCBI
RefSeq Acc Id: XM_538231   ⟹   XP_538231
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.110635,384 - 640,715 (+)NCBI
Dog10K_Boxer_Tasha10700,688 - 704,049 (+)NCBI
Sequence:
RefSeq Acc Id: XP_538231   ⟸   XM_538231
- UniProtKB: A0A8C0NA50 (UniProtKB/TrEMBL),   A0A8I3N7Q4 (UniProtKB/TrEMBL),   A0A8C0LHE6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000000177   ⟸   ENSCAFT00000000198
RefSeq Acc Id: XP_038343726   ⟸   XM_038487798
RefSeq Acc Id: XP_038469580   ⟸   XM_038613652
RefSeq Acc Id: XP_038534945   ⟸   XM_038679017
- UniProtKB: A0A8C0NA50 (UniProtKB/TrEMBL),   A0A8I3N7Q4 (UniProtKB/TrEMBL),   A0A8C0LHE6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038405615   ⟸   XM_038549687
- UniProtKB: A0A8C0LHE6 (UniProtKB/TrEMBL),   A0A8C0NA50 (UniProtKB/TrEMBL),   A0A8I3N7Q4 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845010977   ⟸   ENSCAFT00845014161


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000000120 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030013516 UniProtKB/TrEMBL
  ENSCAFG00040005395 UniProtKB/TrEMBL
  ENSCAFG00845008036 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000000198.4 UniProtKB/TrEMBL
  ENSCAFT00030025017.1 UniProtKB/TrEMBL
  ENSCAFT00040010129.1 UniProtKB/TrEMBL
  ENSCAFT00845014161 ENTREZGENE
  ENSCAFT00845014161.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1250.10 UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/TrEMBL
  IL-23_alpha UniProtKB/TrEMBL
KEGG Report cfa:481110 UniProtKB/TrEMBL
NCBI Gene IL23A ENTREZGENE
PANTHER INTERLEUKIN-23 SUBUNIT ALPHA UniProtKB/TrEMBL
  PTHR15947 UniProtKB/TrEMBL
Pfam IL23 UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/TrEMBL
UniProt A0A8C0LHE6 ENTREZGENE
  A0A8C0NA50 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3N7Q4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:41972 ENTREZGENE