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Gene: Il23a (interleukin 23 subunit alpha) Chinchilla lanigera

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Symbol:

Il23a

Name:

interleukin 23 subunit alpha

RGD ID:

8734119

Description:

ENCODES a protein that exhibits interleukin-23 receptor binding (ortholog); INVOLVED IN cell surface receptor signaling pathway via JAK-STAT (ortholog); cell surface receptor signaling pathway via STAT (ortholog); defense response to Gram-negative bacterium (ortholog); PARTICIPATES IN interleukin-23 signaling pathway; ASSOCIATED WITH Amebic Liver Abscess (ortholog); Animal Toxoplasmosis (ortholog); atopic dermatitis (ortholog); FOUND IN extracellular space (ortholog); interleukin-23 complex (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

interleukin 23, alpha subunit p19; interleukin-23 subunit alpha

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	3,947,803 - 3,949,312 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	3,946,964 - 3,949,180 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Amebic Liver Abscess (ISO)

Animal Toxoplasmosis (ISO)

atopic dermatitis (ISO)

Bovine Tuberculosis (ISO)

campylobacteriosis (ISO)

cataract 15 multiple types (ISO)

Chagas Cardiomyopathy (ISO)

Chagas disease (ISO)

Charcot-Marie-Tooth disease axonal type 2U (ISO)

Clostridium difficile colitis (ISO)

cryptococcosis (ISO)

cutaneous leishmaniasis (ISO)

Experimental Allergic Asthma (ISO)

Experimental Colitis (ISO)

gastric ulcer (ISO)

herpes simplex virus keratitis (ISO)

INTERSTITIAL LUNG AND LIVER DISEASE (ISO)

Klebsiella pneumonia (ISO)

listeriosis (ISO)

Middle East respiratory syndrome (ISO)

oral candidiasis (ISO)

paraplegia (ISO)

pneumocystosis (ISO)

psoriasis (ISO)

pulmonary tuberculosis (ISO)

rheumatoid arthritis (ISO)

severe acute respiratory syndrome (ISO)

tularemia (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell surface receptor signaling pathway via JAK-STAT (ISO)

cell surface receptor signaling pathway via STAT (ISO)

defense response to Gram-negative bacterium (ISO)

negative regulation of interleukin-10 production (ISO)

positive regulation of activated T cell proliferation (ISO)

positive regulation of defense response to virus by host (ISO)

positive regulation of granulocyte macrophage colony-stimulating factor production (ISO)

positive regulation of interleukin-10 production (ISO)

positive regulation of interleukin-12 production (ISO)

positive regulation of interleukin-17 production (ISO)

positive regulation of memory T cell differentiation (ISO)

positive regulation of natural killer cell proliferation (ISO)

positive regulation of neutrophil chemotaxis (ISO)

positive regulation of NK T cell activation (ISO)

positive regulation of NK T cell proliferation (ISO)

positive regulation of osteoclast differentiation (ISO)

positive regulation of T cell mediated cytotoxicity (ISO)

positive regulation of T cell proliferation (ISO)

positive regulation of T-helper 1 type immune response (ISO)

positive regulation of T-helper 17 cell lineage commitment (ISO)

positive regulation of T-helper 17 type immune response (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of tumor necrosis factor production (ISO)

positive regulation of type II interferon production (ISO)

T cell proliferation (ISO)

Cellular Component

extracellular space (ISO)

interleukin-23 complex (ISO)

Molecular Function

interleukin-23 receptor binding (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

interleukin-23 signaling pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Il23a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955458	3,947,803 - 3,949,312 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955458	3,946,964 - 3,949,180 (+)	NCBI	ChiLan1.0	ChiLan1.0

IL23A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	56,338,884 - 56,340,410 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	56,334,174 - 56,340,410 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	56,732,668 - 56,734,194 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	55,018,930 - 55,020,461 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	55,018,929 - 55,020,460	NCBI
Celera	12	56,386,015 - 56,387,546 (+)	NCBI		Celera
Cytogenetic Map	12	q13.3	NCBI
HuRef	12	53,771,325 - 53,772,856 (+)	NCBI		HuRef
CHM1_1	12	56,700,047 - 56,701,578 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	56,306,530 - 56,308,056 (+)	NCBI		T2T-CHM13v2.0

Il23a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	128,132,009 - 128,133,953 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	128,132,008 - 128,134,621 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	128,296,140 - 128,298,084 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	128,296,139 - 128,298,752 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	127,733,196 - 127,735,140 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	127,699,089 - 127,701,033 (-)	NCBI		MGSCv36	mm8
Celera	10	130,684,464 - 130,686,407 (-)	NCBI		Celera
Cytogenetic Map	10	D3	NCBI
cM Map	10	76.51	NCBI

Il23a
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	1,306,320 - 1,308,434 (-)	NCBI		GRCr8
mRatBN7.2	7	721,809 - 723,923 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	721,809 - 723,923 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	3,478,053 - 3,480,168 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	5,354,036 - 5,356,151 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	5,656,694 - 5,658,809 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	2,710,609 - 2,712,723 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	2,710,609 - 2,712,723 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	2,689,128 - 2,691,242 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	1,584,112 - 1,586,226 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	7	1,584,111 - 1,586,226 (-)	NCBI
Celera	7	597,260 - 599,374 (-)	NCBI		Celera
Cytogenetic Map	7	q11	NCBI

IL23A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	37,992,032 - 37,993,395 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	37,987,711 - 37,990,161 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	32,575,321 - 32,576,856 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	32,828,902 - 32,830,621 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	32,828,902 - 32,830,617 (-)	Ensembl	panpan1.1		panPan2

IL23A
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	635,384 - 640,715 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	638,719 - 640,359 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	700,688 - 704,049 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	646,091 - 649,452 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	647,540 - 649,181 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	623,343 - 626,704 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	866,496 - 869,858 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	990,220 - 993,580 (+)	NCBI		UU_Cfam_GSD_1.0

Il23a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	58,124,372 - 58,126,957 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936646	743,688 - 745,836 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936646	743,630 - 745,998 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

IL23A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	21,732,165 - 21,734,267 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	21,732,416 - 21,733,981 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

IL23A
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	52,289,486 - 52,296,735 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	52,295,106 - 52,297,244 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	193,689,882 - 193,696,291 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Il23a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624802	11,662,753 - 11,665,418 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624802	11,662,851 - 11,664,444 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005397309	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01047355	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01073810	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSCLAT00000016715 ⟹ ENSCLAP00000016551

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955458	3,947,803 - 3,949,312 (+)	Ensembl

RefSeq Acc Id:

XM_005397309 ⟹ XP_005397366

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955458	3,946,964 - 3,949,180 (+)	NCBI

Sequence:

show sequence

ATGGTGAGACCCTGTCTCAAAAAAAAGACCAAAAAAAATCAGGTGGTTTTTAACCTCTCCCCAG
TGTTCACCGCAGGAGGAGCAGGCACGACACCTTCTGCCGCATTCCCAGGGCTTCCGAGTCAGGA
GGGTGCCTCTGAGTCTGTCCTCTTCCTGGAAGCCAGCACCACCGGTGAAAAGAACAGTTCCCAA
TGGAGAAAAAGCAGCTCCTTTTTCTTAGATAGTGGGCATCGCATAGGACCCAAACCTCATCCCA
TCTTCCCTTCCATCCTTCTGGGAGCTGAGCAAGTGCTTCTGTTTTGGTTGTTTCTCATGCAAGA
GGAAGTGAGGAAATTAGGTTTGGGGTGGGGTAGGGGTAAAGCTTTGGGAGGCAAAAAAAACCGG
GCAGATTAATCAGGAAGGAACTTGAGGCCAGATTAATTTAAATGTTCGTTACTTCCCCCGCCCC
TCTCTGGCCGTTTGGATTCCTGGAGAGCATTACACATGTGTCCCATCCGAGGCCTCCGGCCCCA
GCGGCCTCACTGTCCATTTCCCCTGGAACAGAGGATGCATACCTGGGCTCTCCACCGAGGGAGA
TGATGCAGGGAGGGGAATCCCACCTGCTGTGAGTCACCTGCTGGTGTAAAGGGCGGGCCTTGCA
CTGCAGAGACCTTAAAAAGACTCGGAGACAGAGGGAGGAAAACAAGGGGAACCAGCTCAGAAAC
TCTGTGAGCAGCAAGAACCAGAACCAGACACAGAACAGAAGAGAATCAGGCTCCGAGCAAGGGG
AAGTGGGAAGAGATTCCTGCGGGACTGGTGCAAGCCCCTGAGCCAGGCAGATTCGAGAAGCGGG
TGACGAGATGCTGGGGGGCACAGCTGTGATGCTGCTACTGCTGCTCCCCTGGGCGGCGCAGGCC
CGGGCAGTCTCTGGGAGCAGCAGCCCTTCCTGGGCCCAGTGCCAGCGGCTGTCACGGAAGCTCT
GCACGCTGGCTTGGAGTGCACATCCGTCAGCAGGACATGTGGATCCACCAAGAGAAGAGGGAGA
CGAAGAGAATACCGATGGCGTCCCCCACATCCGGTGTGGGGACGGCTGCGACCCACAAGGGCTG
AAGGACAGCAGTCGGTTCTGTCTGCAGAGGATCTACCAGGGTCTGGTTTTTTACCAGAAGCTGC
TGGGCTCGGACATTTTCACGGGGGACCCTGCACTACTCCCTGATGGCCTGGCAGGCCAGCTTCA
GGCCTCCCTGCTGCGGCTCAGCCAACTCCTACAGCCTGAGGGTCCCCAGCGGGAGCCTCAGACG
CCCAGCCTCAGCCCCAGCCAGCCTTGGCAGCGTCTCCTGCTTCGGGTCAAGATCCTCCGCAGCC
TCCAGGCCTTCGTGGCTGTAGCCGCCCGCGTCTTTGGCCATGGAGCAGCAAACCTGAGCCCCTA
AGGCCGACACCTAAGGGTGGCGCTCAGCTCTCTGCGGCTCGGGAAGGACAAATCCACTAGCTCA
GGCACCTGAGGGCCAGTGAGCGAGTTAGTCCGTTAATTTTAATGGGACCCACTTGTTAAAAAAT
GACCAATACTGACTCACGATGTTGACCTGTGACAAAGCTGCATATTTATTAGATGGGAAGGGAA
ATGTTGGTATTATTTATCCTCACAGGCGCAGTCTGGGGAGGACTATTTATTGTATTTATAAGGA
ATTATGTTATTTTTTTTCAATAAAGACTTATTTATGTGACTCT

hide sequence

Protein Sequences


Protein RefSeqs	XP_005397366	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000016551
	ENSCLAP00000016551.1

RefSeq Acc Id:	XP_005397366 ⟸ XM_005397309
- UniProtKB:	A0A8C2YQU6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MLGGTAVMLLLLLPWAAQARAVSGSSSPSWAQCQRLSRKLCTLAWSAHPSAGHVDPPREEGDEE NTDGVPHIRCGDGCDPQGLKDSSRFCLQRIYQGLVFYQKLLGSDIFTGDPALLPDGLAGQLQAS LLRLSQLLQPEGPQREPQTPSLSPSQPWQRLLLRVKILRSLQAFVAVAARVFGHGAANLSP hide sequence

Ensembl Acc Id:

ENSCLAP00000016551 ⟸ ENSCLAT00000016715

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000011380	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000016715	ENTREZGENE
	ENSCLAT00000016715.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.1250.10	UniProtKB/TrEMBL
InterPro	4_helix_cytokine-like_core	UniProtKB/TrEMBL
	IL-23_alpha	UniProtKB/TrEMBL
NCBI Gene	Il23a	ENTREZGENE
PANTHER	INTERLEUKIN-23 SUBUNIT ALPHA	UniProtKB/TrEMBL
	PTHR15947	UniProtKB/TrEMBL
Pfam	IL23	UniProtKB/TrEMBL
Superfamily-SCOP	SSF47266	UniProtKB/TrEMBL
UniProt	A0A8C2YQU6	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Il23a	interleukin 23 subunit alpha		interleukin 23, alpha subunit p19	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Annotations - PID (archival)