IL23A (interleukin 23 subunit alpha) - Rat Genome Database

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Gene: IL23A (interleukin 23 subunit alpha) Homo sapiens
Analyze
Symbol: IL23A
Name: interleukin 23 subunit alpha
RGD ID: 731906
HGNC Page HGNC
Description: Contributes to interleukin-23 receptor binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of lymphocyte proliferation; and positive regulation of peptidyl-tyrosine phosphorylation. Part of interleukin-23 complex.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: IL-23; IL-23 subunit alpha; IL-23-A; IL-23A; IL-23p19; IL23P19; interleukin 23 p19 subunit; interleukin 23, alpha subunit p19; interleukin-23 subunit alpha; interleukin-23 subunit p19; interleukin-six, G-CSF related factor; JKA3 induced upon T-cell activation; MGC79388; P19; SGRF
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1256,334,174 - 56,340,410 (+)EnsemblGRCh38hg38GRCh38
GRCh381256,334,159 - 56,340,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371256,732,668 - 56,734,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,018,930 - 55,020,461 (+)NCBINCBI36hg18NCBI36
Build 341255,018,929 - 55,020,460NCBI
Celera1256,386,015 - 56,387,546 (+)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1253,771,325 - 53,772,856 (+)NCBIHuRef
CHM1_11256,700,047 - 56,701,578 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2-hydroxypropanoic acid  (EXP)
2-tert-butylhydroquinone  (EXP)
4-hydroxy-N,1-dimethyl-2-oxo-N-phenyl-3-quinolinecarboxamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
6alpha-methylprednisolone  (EXP)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
aripiprazole  (EXP)
aristolochic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP)
arsenous acid  (ISO)
azathioprine  (EXP)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
berberine  (ISO)
beta-D-glucan  (EXP)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
bortezomib  (EXP)
bucladesine  (EXP)
butanal  (EXP)
cadmium atom  (EXP)
cadmium dichloride  (ISO)
calciol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
celastrol  (ISO)
cisplatin  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (EXP)
cyanidin cation  (ISO)
cyclophosphamide  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (EXP)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (EXP)
dimethyl sulfoxide  (EXP)
disodium selenite  (EXP)
doxorubicin  (EXP,ISO)
endosulfan  (ISO)
estriol  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (EXP)
ferulic acid  (ISO)
flutamide  (ISO)
folic acid  (ISO)
fragrance  (EXP)
furan  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (EXP)
hydroxychloroquine  (ISO)
imiquimod  (ISO)
levamisole  (ISO)
linuron  (ISO)
lipopolysaccharide  (EXP,ISO)
manganese(II) chloride  (ISO)
medroxyprogesterone acetate  (EXP)
melphalan  (ISO)
methotrexate  (EXP,ISO)
misoprostol  (EXP)
muramyl dipeptide  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP)
nimesulide  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
PCB138  (ISO)
peptidoglycan  (EXP)
phenytoin  (ISO)
phorbol 12,13-dibutanoate  (EXP)
phytoestrogen  (ISO)
pioglitazone  (ISO)
piroxicam  (EXP)
potassium dichromate  (ISO)
prednisolone  (EXP)
prostaglandin E1  (ISO)
prostaglandin E2  (EXP,ISO)
rac-lactic acid  (EXP)
resiquimod  (EXP)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP,ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (EXP)
sodium sulfate  (ISO)
tacrolimus hydrate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (EXP)
tofacitinib  (ISO)
triptonide  (ISO)
tunicamycin  (EXP)
vincristine  (EXP)
wortmannin  (EXP)
zinc protoporphyrin  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
defense response to Gram-negative bacterium  (IDA)
defense response to virus  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
negative regulation of interleukin-10 production  (IMP)
positive regulation of activated T cell proliferation  (IDA)
positive regulation of activation of Janus kinase activity  (IBA,IDA)
positive regulation of defense response to virus by host  (IDA,ISS)
positive regulation of granulocyte macrophage colony-stimulating factor production  (IDA)
positive regulation of inflammatory response  (IC)
positive regulation of interferon-gamma production  (IDA,TAS)
positive regulation of interleukin-10 production  (IDA,TAS)
positive regulation of interleukin-12 production  (IDA)
positive regulation of interleukin-17 production  (IDA)
positive regulation of memory T cell differentiation  (ISS)
positive regulation of natural killer cell activation  (IC)
positive regulation of natural killer cell proliferation  (IDA)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of NIK/NF-kappaB signaling  (TAS)
positive regulation of NK T cell activation  (IC,IDA)
positive regulation of NK T cell proliferation  (IDA)
positive regulation of osteoclast differentiation  (IDA)
positive regulation of T cell mediated cytotoxicity  (ISS)
positive regulation of T cell proliferation  (IBA,IDA)
positive regulation of T-helper 1 type immune response  (IDA,ISS,NAS,TAS)
positive regulation of T-helper 17 cell lineage commitment  (IBA,ISS)
positive regulation of T-helper 17 type immune response  (ISS)
positive regulation of tissue remodeling  (IC)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (IMP)
positive regulation of tyrosine phosphorylation of STAT protein  (IDA)
regulation of tyrosine phosphorylation of STAT protein  (IDA)
signal transduction  (IEA)
T cell proliferation  (ISO)
tissue remodeling  (IEA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Bereswill S, etal., PLoS One. 2016 Jun 20;11(6):e0158020. doi: 10.1371/journal.pone.0158020. eCollection 2016.
2. Broberg EK, etal., J Interferon Cytokine Res. 2002 Jun;22(6):641-51. doi: 10.1089/10799900260100123.
3. Chackerian AA, etal., Infect Immun. 2006 Nov;74(11):6092-9. doi: 10.1128/IAI.00621-06. Epub 2006 Aug 21.
4. Conti HR, etal., J Exp Med. 2009 Feb 16;206(2):299-311. doi: 10.1084/jem.20081463. Epub 2009 Feb 9.
5. Cooper AM, etal., J Immunol. 2002 Feb 1;168(3):1322-7. doi: 10.4049/jimmunol.168.3.1322.
6. Cruz A, etal., J Exp Med. 2010 Aug 2;207(8):1609-16. doi: 10.1084/jem.20100265. Epub 2010 Jul 12.
7. Dietze-Schwonberg K, etal., Exp Dermatol. 2018 Jan;27(1):101-103. doi: 10.1111/exd.13455. Epub 2017 Dec 6.
8. Ding H, etal., PLoS One. 2013 Jul 11;8(7):e69384. doi: 10.1371/journal.pone.0069384. Print 2013.
9. Erdmann H, etal., Immunobiology. 2013 Jun;218(6):910-23. doi: 10.1016/j.imbio.2012.10.005. Epub 2012 Oct 26.
10. Happel KI, etal., Alcohol Clin Exp Res. 2006 Jul;30(7):1200-7. doi: 10.1111/j.1530-0277.2006.00144.x.
11. Happel KI, etal., J Exp Med. 2005 Sep 19;202(6):761-9. doi: 10.1084/jem.20050193. Epub 2005 Sep 12.
12. Heimesaat MM, etal., Gut Pathog. 2016 Jul 6;8:21. doi: 10.1186/s13099-016-0106-4. eCollection 2016.
13. Indramohan M, etal., Infect Immun. 2012 Dec;80(12):4099-105. doi: 10.1128/IAI.00589-12. Epub 2012 Sep 10.
14. Khader SA, etal., J Immunol. 2005 Jul 15;175(2):788-95. doi: 10.4049/jimmunol.175.2.788.
15. Kitada S, etal., J Exp Med. 2017 May 1;214(5):1313-1331. doi: 10.1084/jem.20161076. Epub 2017 Mar 29.
16. Kleinschek MA, etal., J Immunol. 2006 Jan 15;176(2):1098-106. doi: 10.4049/jimmunol.176.2.1098.
17. Kurtz SL, etal., PLoS One. 2014 Oct 8;9(10):e109898. doi: 10.1371/journal.pone.0109898. eCollection 2014.
18. Lieberman LA, etal., J Immunol. 2004 Aug 1;173(3):1887-93. doi: 10.4049/jimmunol.173.3.1887.
19. McDermott AJ, etal., Immunology. 2016 Jan;147(1):114-24. doi: 10.1111/imm.12545. Epub 2015 Dec 2.
20. Meeks KD, etal., J Immunol. 2009 Dec 15;183(12):8026-34. doi: 10.4049/jimmunol.0901588.
21. Noll J, etal., J Hepatol. 2016 May;64(5):1147-1157. doi: 10.1016/j.jhep.2016.01.013. Epub 2016 Jan 22.
22. Ogawa R, etal., Allergol Int. 2015 Sep;64 Suppl:S24-9. doi: 10.1016/j.alit.2015.04.005. Epub 2015 May 16.
23. Okada Y, etal., Clin Exp Immunol. 2013 Dec;174(3):459-71. doi: 10.1111/cei.12200.
24. Peltoniemi J, etal., Clin Exp Immunol. 2004 Aug;137(2):305-12. doi: 10.1111/j.1365-2249.2004.02528.x.
25. Peng J, etal., Cell Res. 2010 Jan;20(1):62-71. Epub 2009 Nov 24.
26. Pipeline to import KEGG annotations from KEGG into RGD
27. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
28. RGD automated import pipeline for gene-chemical interactions
29. Rudner XL, etal., Infect Immun. 2007 Jun;75(6):3055-61. doi: 10.1128/IAI.01329-06. Epub 2007 Apr 2.
30. Szymczak WA, etal., Am J Pathol. 2012 Apr;180(4):1547-59. doi: 10.1016/j.ajpath.2011.12.038. Epub 2012 Feb 16.
31. Teixeira-Coelho M, etal., Int Immunol. 2011 Feb;23(2):89-96. doi: 10.1093/intimm/dxq459. Epub 2010 Dec 14.
Additional References at PubMed
PMID:8570611   PMID:11114383   PMID:11390512   PMID:12023369   PMID:12421946   PMID:12477932   PMID:12525561   PMID:12671732   PMID:12847224   PMID:12975309   PMID:14707118   PMID:15070757  
PMID:15114670   PMID:15265908   PMID:15486065   PMID:15489334   PMID:15583831   PMID:15731058   PMID:16300465   PMID:16339539   PMID:16341674   PMID:16342235   PMID:16424222   PMID:16482511  
PMID:16670765   PMID:16688182   PMID:16751425   PMID:16772281   PMID:17007011   PMID:17021762   PMID:17182554   PMID:17187052   PMID:17207965   PMID:17236132   PMID:17564777   PMID:17606463  
PMID:17763202   PMID:17888176   PMID:17945537   PMID:18029348   PMID:18054783   PMID:18180107   PMID:18190588   PMID:18311793   PMID:18319400   PMID:18373953   PMID:18408745   PMID:18490716  
PMID:18497880   PMID:18579762   PMID:18606709   PMID:18675459   PMID:18680750   PMID:18708069   PMID:18752933   PMID:18754016   PMID:18786233   PMID:18825388   PMID:19034457   PMID:19040306  
PMID:19088061   PMID:19169254   PMID:19201028   PMID:19247658   PMID:19262574   PMID:19264456   PMID:19322214   PMID:19333939   PMID:19426392   PMID:19431078   PMID:19479806   PMID:19542049  
PMID:19542431   PMID:19587005   PMID:19605880   PMID:19657406   PMID:19705136   PMID:19797506   PMID:19845828   PMID:19900478   PMID:19915944   PMID:19929695   PMID:20027291   PMID:20054003  
PMID:20071030   PMID:20106535   PMID:20154336   PMID:20331378   PMID:20428758   PMID:20603238   PMID:20624950   PMID:20682175   PMID:20682672   PMID:20701979   PMID:20840651   PMID:20873540  
PMID:20886035   PMID:20953190   PMID:20956338   PMID:21116820   PMID:21145044   PMID:21145111   PMID:21161669   PMID:21227898   PMID:21231819   PMID:21302302   PMID:21387004   PMID:21402701  
PMID:21515794   PMID:21516111   PMID:21518507   PMID:21531892   PMID:21547355   PMID:21560441   PMID:21576383   PMID:21623003   PMID:21641076   PMID:21670317   PMID:21740501   PMID:21747388  
PMID:21873635   PMID:21931205   PMID:22003203   PMID:22127978   PMID:22144400   PMID:22174449   PMID:22177788   PMID:22209993   PMID:22262980   PMID:22298331   PMID:22417709   PMID:22505413  
PMID:22559912   PMID:22621182   PMID:22678234   PMID:22683003   PMID:22688014   PMID:22705151   PMID:22759859   PMID:22851868   PMID:22909235   PMID:22955875   PMID:22965992   PMID:23050001  
PMID:23053983   PMID:23116756   PMID:23121980   PMID:23250909   PMID:23268293   PMID:23327801   PMID:23376980   PMID:23388728   PMID:23393581   PMID:23425136   PMID:23472658   PMID:23489789  
PMID:23520984   PMID:23563201   PMID:23579029   PMID:23673284   PMID:23679818   PMID:23740229   PMID:23755218   PMID:23825942   PMID:23910013   PMID:24040001   PMID:24054330   PMID:24067979  
PMID:24144296   PMID:24224652   PMID:24384828   PMID:24568095   PMID:24577500   PMID:24643777   PMID:24781050   PMID:24796719   PMID:24899786   PMID:24909386   PMID:24910175   PMID:24924839  
PMID:24957500   PMID:24982422   PMID:24990863   PMID:24995325   PMID:25015728   PMID:25046339   PMID:25083738   PMID:25234720   PMID:25253467   PMID:25371211   PMID:25416956   PMID:25439430  
PMID:25525302   PMID:25553835   PMID:25562331   PMID:25562560   PMID:25621490   PMID:25626905   PMID:25639230   PMID:25646481   PMID:25649806   PMID:25670394   PMID:25721268   PMID:25769808  
PMID:25769911   PMID:25789703   PMID:25793426   PMID:25799392   PMID:25877925   PMID:25887118   PMID:26062426   PMID:26151690   PMID:26186194   PMID:26295034   PMID:26303210   PMID:26656739  
PMID:26657845   PMID:26709220   PMID:26928603   PMID:26952371   PMID:26980441   PMID:26987707   PMID:27053620   PMID:27062688   PMID:27146815   PMID:27155366   PMID:27240992   PMID:27245439  
PMID:27315572   PMID:27343994   PMID:27388654   PMID:27400195   PMID:27515793   PMID:27551155   PMID:27554821   PMID:27563808   PMID:27660093   PMID:27665460   PMID:27681197   PMID:27716059  
PMID:27738346   PMID:27807862   PMID:27820818   PMID:27836676   PMID:27869179   PMID:27893410   PMID:28282579   PMID:28341820   PMID:28509479   PMID:28514442   PMID:28609751   PMID:28646040  
PMID:28646409   PMID:28653490   PMID:28692864   PMID:28728847   PMID:28757426   PMID:28829805   PMID:28869081   PMID:29091911   PMID:29119640   PMID:29258893   PMID:29394248   PMID:29409751  
PMID:29434604   PMID:29514093   PMID:29574157   PMID:29643359   PMID:29650963   PMID:29731755   PMID:29763989   PMID:29950727   PMID:29997244   PMID:30116153   PMID:30208882   PMID:30292634  
PMID:30463609   PMID:30481093   PMID:30537793   PMID:30542702   PMID:30696656   PMID:30814438   PMID:30817049   PMID:30854931   PMID:30903865   PMID:30917537   PMID:31002145   PMID:31019514  
PMID:31230747   PMID:31237437   PMID:31434744   PMID:31511508   PMID:31527131   PMID:31537133   PMID:31978612   PMID:32020720   PMID:32022950   PMID:32152765   PMID:32209656   PMID:32296183  
PMID:32312425   PMID:32599588   PMID:32726660   PMID:32998371   PMID:33007332   PMID:33066031   PMID:33082377   PMID:33259477   PMID:33278500   PMID:33559857   PMID:33766235   PMID:33851590  
PMID:33884734  


Genomics

Comparative Map Data
IL23A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1256,334,174 - 56,340,410 (+)EnsemblGRCh38hg38GRCh38
GRCh381256,334,159 - 56,340,410 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371256,732,668 - 56,734,194 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361255,018,930 - 55,020,461 (+)NCBINCBI36hg18NCBI36
Build 341255,018,929 - 55,020,460NCBI
Celera1256,386,015 - 56,387,546 (+)NCBI
Cytogenetic Map12q13.3NCBI
HuRef1253,771,325 - 53,772,856 (+)NCBIHuRef
CHM1_11256,700,047 - 56,701,578 (+)NCBICHM1_1
Il23a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,132,009 - 128,133,953 (-)NCBIGRCm39mm39
GRCm39 Ensembl10128,132,008 - 128,134,621 (-)Ensembl
GRCm3810128,296,140 - 128,298,084 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,296,139 - 128,298,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv3710127,733,196 - 127,735,140 (-)NCBIGRCm37mm9NCBIm37
MGSCv3610127,699,089 - 127,701,033 (-)NCBImm8
Celera10130,684,464 - 130,686,407 (-)NCBICelera
Cytogenetic Map10D3NCBI
Il23a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.27721,809 - 723,923 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl7721,809 - 723,923 (-)Ensembl
Rnor_6.072,710,609 - 2,712,723 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl72,710,609 - 2,712,723 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.072,689,128 - 2,691,242 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.471,584,112 - 1,586,226 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.171,584,111 - 1,586,226 (-)NCBI
Celera7597,260 - 599,374 (-)NCBICelera
Cytogenetic Map7q11NCBI
Il23a
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,947,803 - 3,949,312 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,946,964 - 3,949,180 (+)NCBIChiLan1.0ChiLan1.0
IL23A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11232,828,902 - 32,830,621 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1232,828,902 - 32,830,617 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01232,575,321 - 32,576,856 (-)NCBIMhudiblu_PPA_v0panPan3
IL23A
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.110635,384 - 640,715 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl10638,719 - 640,359 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10700,688 - 704,049 (+)NCBI
ROS_Cfam_1.010646,091 - 649,452 (+)NCBI
UMICH_Zoey_3.110623,343 - 626,704 (+)NCBI
UNSW_CanFamBas_1.010866,496 - 869,858 (+)NCBI
UU_Cfam_GSD_1.010990,220 - 993,580 (+)NCBI
Il23a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,124,372 - 58,126,957 (-)NCBI
SpeTri2.0NW_004936646743,630 - 745,998 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL23A
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,732,165 - 21,734,267 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,732,416 - 21,733,981 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
IL23A
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11152,289,486 - 52,296,735 (+)NCBI
ChlSab1.1 Ensembl1152,295,106 - 52,297,244 (+)Ensembl
Vero_WHO_p1.0NW_023666037193,689,882 - 193,696,291 (-)NCBI
Il23a
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462480211,662,851 - 11,664,444 (-)NCBI

Position Markers
RH92829  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,733,944 - 56,734,100UniSTSGRCh37
Build 361255,020,211 - 55,020,367RGDNCBI36
Celera1256,387,296 - 56,387,452RGD
Cytogenetic Map12q13.3UniSTS
HuRef1253,772,606 - 53,772,762UniSTS
GeneMap99-GB4 RH Map12249.5UniSTS
PMC321570P2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,733,249 - 56,733,772UniSTSGRCh37
Build 361255,019,516 - 55,020,039RGDNCBI36
Celera1256,386,601 - 56,387,124RGD
Cytogenetic Map12q13.3UniSTS
HuRef1253,771,911 - 53,772,434UniSTS
UniSTS:482436  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371256,732,796 - 56,733,921UniSTSGRCh37
Celera1256,386,148 - 56,387,273UniSTS
HuRef1253,771,458 - 53,772,583UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:132
Interacting mature miRNAs:137
Transcripts:ENST00000228534
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High 2
Medium 54 6 11 4 446 3 15 3 5 15 449 97 4 4
Low 1396 1413 1640 586 1321 438 2902 454 2373 344 903 1492 157 1027 1512 3
Below cutoff 981 1544 72 32 172 24 1355 1647 1321 58 97 17 10 172 1195 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_016584 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011538477 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB030000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB030001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC025574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF301620 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ506993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY359083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066267 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC066269 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067511 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC067513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM842783 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM851337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS498403 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HI574128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JA104589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U38443 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000228534   ⟹   ENSP00000228534
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1256,338,884 - 56,340,410 (+)Ensembl
RefSeq Acc Id: ENST00000619177
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1256,334,208 - 56,340,329 (+)Ensembl
RefSeq Acc Id: ENST00000622119
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1256,334,174 - 56,340,305 (+)Ensembl
RefSeq Acc Id: NM_016584   ⟹   NP_057668
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,338,884 - 56,340,410 (+)NCBI
GRCh371256,732,663 - 56,734,194 (+)ENTREZGENE
Build 361255,018,930 - 55,020,461 (+)NCBI Archive
HuRef1253,771,325 - 53,772,856 (+)ENTREZGENE
CHM1_11256,700,047 - 56,701,578 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011538477   ⟹   XP_011536779
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,334,159 - 56,340,410 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_057668   ⟸   NM_016584
- Peptide Label: precursor
- UniProtKB: Q9NPF7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011536779   ⟸   XM_011538477
- Peptide Label: isoform X1
- UniProtKB: Q9NPF7 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000228534   ⟸   ENST00000228534

Promoters
RGD ID:6790131
Promoter ID:HG_KWN:15904
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   K562,   Lymphoblastoid
Transcripts:ENST00000228534
Position:
Human AssemblyChrPosition (strand)Source
Build 361255,018,011 - 55,019,362 (+)MPROMDB
RGD ID:7224425
Promoter ID:EPDNEW_H17958
Type:initiation region
Name:IL23A_2
Description:interleukin 23 subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17953  EPDNEW_H17959  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,334,179 - 56,334,239EPDNEW
RGD ID:7224427
Promoter ID:EPDNEW_H17959
Type:initiation region
Name:IL23A_1
Description:interleukin 23 subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H17953  EPDNEW_H17958  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381256,338,884 - 56,338,944EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:1-133851895)x3 copy number gain See cases [RCV000258805] Chr12:1..133851895 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic|likely pathogenic
NM_016584.3(IL23A):c.318G>A (p.Ser106=) single nucleotide variant not specified [RCV000455797] Chr12:56339747 [GRCh38]
Chr12:56733531 [GRCh37]
Chr12:12q13.3
benign
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902)x3 copy number gain See cases [RCV000510482] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:173787-133777902) copy number gain See cases [RCV000511643] Chr12:173787..133777902 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:191619-133777645)x3 copy number gain not provided [RCV000750246] Chr12:191619..133777645 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12p13.33-q24.33(chr12:621220-133779118)x3 copy number gain not provided [RCV000750253] Chr12:621220..133779118 [GRCh37]
Chr12:12p13.33-q24.33
pathogenic
GRCh37/hg19 12q13.2-14.1(chr12:55552371-62126304)x3 copy number gain not provided [RCV001006505] Chr12:55552371..62126304 [GRCh37]
Chr12:12q13.2-14.1
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:15488 AgrOrtholog
COSMIC IL23A COSMIC
Ensembl Genes ENSG00000110944 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000228534 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000228534 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000110944 GTEx
HGNC ID HGNC:15488 ENTREZGENE
Human Proteome Map IL23A Human Proteome Map
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot
  IL-23_alpha UniProtKB/Swiss-Prot
KEGG Report hsa:51561 UniProtKB/Swiss-Prot
NCBI Gene 51561 ENTREZGENE
OMIM 605580 OMIM
PANTHER PTHR15947 UniProtKB/Swiss-Prot
Pfam IL23 UniProtKB/Swiss-Prot
PharmGKB PA29824 PharmGKB
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot
UniProt IL23A_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6NZ80 UniProtKB/Swiss-Prot
  Q6NZ82 UniProtKB/Swiss-Prot
  Q9H2A5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-15 IL23A  interleukin 23 subunit alpha  IL23A  interleukin 23, alpha subunit p19  Symbol and/or name change 5135510 APPROVED